Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis

From Wiki Journal Club
Jump to: navigation, search
. "Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis". NEJM. . :.
PubMed


Clinical Question

Bottom Line

Major Points

Guidelines

Design

  • Setting:
  • Enrollment:
  • Mean follow-up:
  • Analysis:
  • Primary outcome:

Population

Inclusion Criteria

Exclusion Criteria

  • Tracheostomy

Baseline Characteristics

Interventions

Outcomes

Comparisons are intensive therapy vs. standard therapy.

Primary Outcomes

Annual rate of nonfatal MI or nonfatal stroke or cardiovascular death
2.11% vs. 2.29% (HR 0.90; 95% CI 0.78-1.04; P=0.16)

Secondary Outcomes

Annual rate of death from any cause
1.41% vs. 1.14% (HR 1.22; 95% CI 1.01-1.46; P=0.04)
Annual rate of cardiovascular death
0.79% vs. 0.56% (HR 1.35; 95% CI 1.04-1.76; P=0.02)

Subgroup Analysis

Adverse Events

Criticisms

Funding

The authors disclose no conflicts of interest

Further Reading



https://www.wikijournalclub.org/wiki/WikiJournalClub:Administrators