WikiJournalClub:List of landmark papers/Critical Care

Neuro

• 2000 Kress et al Daily sedation holidays [1]
• 2002 HACA Hypothermia after out-of-hospital cardiac arrest [2]
• 2002 OHCA Hypothermia after out-of-hospital cardiac arrest [3]
• 2007 MENDS Dexmedetomidine vs. lorazepam for ICU patients [4]
• 2008 ABC Spontaneous awakening trials [5]
• 2009 SEDCOM Dexmedetomidine vs. midazolam for ICU patients [6]
• 2010 ACURASYS Cisatracurium in ARDS [7]
• 2015 EUROTHERM 3235 Hypothermia for intracranial hypertension [8]

Cardiovascular

• 2001 Rivers Trial Early goal-directed therapy in sepsis [9]
• 2001 PROWESS Activated Protein C for Severe Sepsis [10]
• 2002 Annane Trial Hydrocortisone plus fludrocortisone in septic shock [11]
• 2004 SAFE Albumin vs. saline in ICU patients [12]
• 2005 PAC-Man PA Catheters in ICU Patients [13]
• 2008 CORTICUS Hydrocortisone in septic shock [14]
• 2008 VASST Norepinephrine plus Vasopressin in septic shock [15]
• 2010 EMShockNet Lactate clearance vs. ScvO2 for EGDT [16]
• 2010 SOAP-II Dopamine vs. norepinephrine in shock [17]
• 2010 Rea et al Compression-only CPR [18]
• 2010 Svensson et al Compression-only CPR [19]
• 2011 PROWESS-SHOCK

Pulmonary

• 2000 ARDSNet Low vs. traditional volumes in ARDS [20]
• 2004 Higher versus Lower PEEP in ARDS [21]
• 2006 Corticosteroids in ARDS [22]
• 2006 FACTT Fluid management in ARDS [23]
• 2006 PAC vs CVC PAC vs. CVC in ALI/ARDS [24]
• 2008 3CPO CPAP/BIPAP for Acute Cardiogenic Pulmonary Edema [25]
• 2008 Express PEEP in ALI/ARDS [26]
• 2008 LOVe Low tidal volumes, recruitment maneuvers and high PEEP in ARDS [27]
• 2010 ACURASYS Cisatracurium in ARDS [28]

Gastrointestinal

• 1994 Risk factors for GI bleed in critically ill [29]
• 2007 Vancomycin vs. Metronidazole in C. difficile Diarrhea [30]
• 2011 Fidaxomicin vs. Vancomycin in C. difficile Diarrhea [31]
• 2011 Early vs. Late TPN in Critical Illness [32]

Hematologic

• 1999 TRICC Hgb ≥7 vs. ≥10 in ICU patients [33]

Infectious Disease

• 2003 PneumA 8 vs. 15 days for VAP [34]
• 2004 Time to Positivity in CRBSI [35]
• 2007 Vancomycin vs. Metronidazole in C. difficile Diarrhea [36]
• 2008 VAT Antibiotics in ventilator-associated tracheobronchitis [37]
• 2010 PRORATA Procalcitonin in ICU patients [38]
• 2011 Fidaxomicin vs. Vancomycin in C. difficile Diarrhea [39]
• 2015 HEAT Paracetamol for fever [40]

Endocrine

• 2001 Leuven Surgical Trial Intensive glycemic therapy in surgical ICU patients [41]
• 2006 Leuven Medical Trial Intensive glycemic therapy in medical ICU patients [42]
• 2009 NICE-SUGAR Intensive glycemic therapy in ICU [43]

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