WikiJournalClub:List of landmark papers/Endocrinology

Diabetes

Intensive glycemic therapy

• 1993 DCCT Intensive glycemic therapy in T1DM [1]
• 1998 UKPDS Intensive glycemic therapy in T2DM [2][3]
• 2005 EDIC Intensive glycemic therapy in T1DM (DCCT follow-up) [4]
• 2008 ACCORD Intensive glycemic therapy in T2DM [5]
• 2008 ADVANCE Intensive glycemic therapy in T2DM [6]
• 2009 VADT Intensive glycemic therapy in T2DM [7]

Ace-inhibitors

• 1993 Captopril in diabetic nephropathy [8]
• 1997 EUCLID Lisinopril in IDDM with minimal albuminuria [9]

Statins

• 2003 HPS Simvastatin in DM without CAD [10]
• 2004 CARDS Atorvastatin in DM without CAD [11]

Diabetes Prevention and treatment

• Finnish Diabetes Prevention Study
• DPP U.S. Diabetes Prevention Program. Metform 31% risk reduction in development of diabetes.
• VISEP Volume Substitution and Insulin Therapy in Severe Sepsis
• GLUCONTROL

ARBs

• RENAAL Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy (NEJM 2001;345:861)[12]
• ARBs irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. (NEJM 2001;345:851) [13]

α-glucosidase inhibitor

• Rosiglitazone significant increase in risk of MI (NEJM 2007;356:2457) [14]
• RECORD addition of rosiglitazone to glucose-lowering therapy in T2DM a/w increase risk of heart failure and some fractures, mainly in women. Rosiglitazone does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose-lowering drugs. (Lancet 2009;373:2125) [15]
• Pioglitazone not associated with increase in MI (JAMA 2007;298:1180) --meta-analysis
• 1998 STOP-NIDDM Acarbose in IGT [16]
• PROactive Prospective Pioglitazone Clinical Trial in Macrovascular Events
• ARIC Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: Atherosclerosis Risk in Communities (ARIC) Study. (Arch Intern Med. 2008;168(22):2440.)

Prevention

• 2002 DPP: Metformin in preventing T2DM [17]

Hypercholesterolemia

• 1994 4S Simvastatin [18]
• 1995 WOSCOPS: Pravastatin in CAD
• 1998 AFCAPS/TexCAPS Lovastatin in primary prevention [19]
• 1998 LIPID Pravastatin [20]
• 2002 Heart Protection Study Simvastatin in CAD [21]
• 2004 CARDS Atorvastatin prevents CVD in T2DM [22]
• 2005 TNT Atorvastatin [23]
• 2006 SPARCL High-dose atorvastatin after stroke/TIA [24]
• 2008 ENHANCE: ezetimibe plus simvastatin no different than simvastatin alone [25]
• 2008 JUPITER: Statins reduce heart attacks and stroke [26]