Aromatherapy with isopropyl alcohol for Nausea
In adult patients that present to the Emerg with nausea and vomiting, does inhaled isopropyl alcohol as compared to oral ondansetron decrease symptoms.
In patients not requiring immediate intravenous intervention, aromatherapy with isopropyl alcohol provides greater relief than oral ondansetron alone at 30 minutes.
Isopropyl Alcohol aromatherapy has been used in several trials, including for post-operative nausea, and have shown little side effects. Common antiemetics including ondansetron, prochlorpromazine, and dimenhydrinate have known side effects including constipation, extrapyramidal side effects, and potentially teratogenic. A previous trial including 80 patients in a convenience sample demonstrated benefit at 10 minutes. Building on this previous work this trial further explored its application in Emerg.
Including 120 patients in an urban, tertiary care facility, this since centre trial compare three arms: inhaled isopropyl alcohol plus oral ondansetron, inhaled isopropyl alcohol with oral placebo, and inhaled placebo with ondansetron. Employing a visual analogue scale (VAS), the primary outcome measure was change in VAS at 30 minutes. Overall the trail showed a benefit in the arms with isopropyl alcohol at 30 minutes but to do this patients were allowed unlimited amounts of alcohol pads and they did not describe the numbers of pad employed. There was difference for Emerg length of stay nor the numbers admitted.
This trial offers a good alternative for patients presenting to Emerg with acute nausea and vomiting. This trial is not without issue. It was in a single centre, had small numbers and may have been under powered for several of the secondary outcomes, and blinding was lost in half of the patients.
As of May 2018, no guidelines have been published that reflect the results of this trial.
- single-center, placebo-controlled, blinded, randomized trial
- Isopropyl Alcohol + Ondansetron (n=40)
- Isopropyl Alcohol + Placebo (n=40)
- Placebo + Ondansetron (n=40)
- Setting: Urban tertiary care academic hospital
- Analysis: modified Intention to treat
- Primary Outcome: Change of nausea score on a visual analogue scale at 30 min
- adults (≥18 years)
- chief complaint of nausea / vomiting
- self-reported nausea severity of 3 or greater on a verbal numeric response scale (range 0 to 10).
- known allergy to isopropyl alcohol or ondansetron
- inability to inhale through the nares (eg, rhinitis)
- recent intake of medications contraindicating alcohol administration (cefoperazone, disulfiram, or metronidazole *altered mental status precluding signed informed consent
- known history of QT-segment prolongation
- clinical suspicion for serotonin syndrome
- treating provider discretion
Isopropyl Alcohol + Ondansetron group displayed
- Demographics: mean age 30.5 years, 50% female,
- Anthropomorphics: mean Weight 77 kg
- Symptoms: mean duration 13.5 h, mean Initial nausea score 53, mean initial pain score 37
- Presumed symptom cause: Infectious gastroenteritis 55%, Food Poisoning 8%, Urinary Track Infection 5%, Headache 3%, Other 29%
- Inhaled isopropyl alcohol + oral ondansetron 4mg
- Inhaled placebo (saline) Ondansetron 4mg orally
- Inhaled isopropyl alcohol + placebo
Comparisons are Isopropyl alcohol + ondansetron vs. Isopropyl alcohol + Placebo vs. Placebo + ondansetron.
- Change in Visual Analogue Scale (VAS) at 30 min
- 30 mm (95% CI 22-37) vs. 32 mm (95% CI 25-39) vs. 9 mm (95% CI 5-14) [Effect size 1 vs. 2 20mm, 2 vs. 3 23mm]
- VAS Pain Scale reduction, mean
- 10mm vs. 11mm vs. 3mm [Effect size 1 vs. 2 7mm, 2 vs. 3 8mm]
- Final Nausea Score, mean
- 16 vs. 16 vs. 29 [Effect size 1 vs. 2 -13mm, 2 vs. 3 -13mm]
- Final Pain Score, mean
- 18 vs. 22 vs. 30 [Effect size 1 vs. 2 -12mm, 2 vs. 3 -8mm]
- Nausea Therapy Satisfaction, mean
- 19 vs. 22 vs. 44
- Vomited during Emerg stay
- 7.5% vs. 0% vs. 7.5%
- Receipt rescue antiemetics
- 28% vs. 25% vs. 45%
- Emerg length of stay
- 217min vs. 224min vs. 210min
- 12% vs. 2.5% vs. 0%
- Adverse events not described
- Selection Bias: general healthy population, less severe symptoms, convenience sample employed
- Blinding was lost on 50% of patients
- Subjective VAS used over objective measure
- Unlimited isopropyl alcohol pads were available for duration of stay, number of pads utilized was not described
- not described
- Hines S et al. Aromatherapy for treatment of postoperative nausea and vomiting. Cochrane Database Syst Rev 2018. 3:CD007598.
- Beadle KL et al. Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med 2016. 68:1-9.e1.
- Carstairs SD & Ondansetron Use in Pregnancy and Birth Defects: A Systematic Review. Obstet Gynecol 2016. 127:878-83.