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ACST-1: Difference between revisions
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<!-- What were the primary outcomes of the study? Be careful with how stats are written. The name of the outcome starts with a semicolon (;) and the actual statistics for that outcome start with a colon (:), for example: --> | <!-- What were the primary outcomes of the study? Be careful with how stats are written. The name of the outcome starts with a semicolon (;) and the actual statistics for that outcome start with a colon (:), for example: --> | ||
; peri-operative mortality and morbidity (death or stroke within 30 days) at 5-years | ; peri-operative mortality and morbidity (death or stroke within 30 days) at 5-years<ref>[http://www.ncbi.nlm.nih.gov/pubmed/15135594 Halliday A, Mansfield A, Marro J, et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. ''Lancet'' 2004;363:1491–1502] | ||
</ref> | |||
''data expressed as % of total CEA'' | ''data expressed as % of total CEA'' | ||
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* However subgroup analyses are not definitive due to the small number of events in the trial.<!-- Were there significant adverse events recorded other than those listed in the secondary outcomes? If so, list them here --> | * However subgroup analyses are not definitive due to the small number of events in the trial.<!-- Were there significant adverse events recorded other than those listed in the secondary outcomes? If so, list them here --> | ||
==Criticisms== | ==Criticisms== | ||
<!-- What criticisms exist about the paper? --> | * Uncertainty if patients achieved ideal blood pressure levels (<140/90 mm Hg) or LDL-C (<2·4 mmol/L) as recommended by JNC 7 and NCEP III guidelines. This affects their absolute risk for stroke.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/20870079 Amarenco P, Labreuche J, Mazighi M. Lessons from carotid endarterectomy and stenting trials. ''Lancet''. 2010;376(9746):1028-31]</ref> | ||
* Lipid-lowering therapy may have been suboptimal in the trial.<ref>Paraskevas KI, Mikhailidis DP, Veith FJ. Best medical treatment for a symptomatic carotid artery stenosis. ''Lancet''. 2011;377(9760):123; author reply 123-4</ref><!-- What criticisms exist about the paper? --> | |||
==Funding== | ==Funding== | ||