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===Secondary outcomes===
===Secondary outcomes===
<i> All outcomes are expressed as a 6-Year Rate per 100 Persons </i>
* All-cause mortality: NS between all three groups
* All-cause mortality: NS between all three groups
* Fatal and nonfatal stroke
* Fatal and nonfatal stroke
** Lisinopril group had 15% higher risk for stroke (p=0.02)
** Lisinopril vs Chlorthalidone: 6.3 vs 5.6 (RR 1.15, 95% CI 1.02-1.30, p=0.02)
* Combined CHD (primary outcome, coronary revascularization, or angina with hospitalization)
* Combined CHD (primary outcome, coronary revascularization, or angina with hospitalization): NS between all three groups
* Combined CVD (combined CHD, stroke, treated angina without hospitalization, HF [fatal, hospitalized, or treated nonhospitalized], and peripheral arterial disease)
* Combined CVD (combined CHD, stroke, treated angina without hospitalization, HF, and peripheral arterial disease)
** Amlodipine group had 38% higher risk of HF (p<0.001), 6-year absolute risk difference of 2.5% and 35% higher risk of hospitalized/fatal HF (p<0.001)
** Lisinopril vs Chlorthalidone: 33.3 vs 30.9 (RR 1.10, 95% CI 1.05-1.16, p<0.001)
* Heart failure
** Lisinopril vs Chlorthalidone: 8.7 vs 7.7 (RR 1.19, 95% CI 1.07-1.31, p<0.001)
** Amlodipine vs Chlorthalidone: 10.2 vs 7.7 (RR 1.38, 95% CI 1.25-1.52, p<0.001)
* Hospitalized/fatal HF
** Amlodipine vs Chlorthalidone: 8.4 vs 6.5 (RR 1.35, 95% CI 1.21-1.50, p<0.001)
* Angina (hospitalized or treated):
** Lisinopril vs Chlorthalidone: 13.6 vs 12.1 (RR 1.11, 95% CI 1.03-1.20, p<0.01)
 
===Subgroup analysis===
===Subgroup analysis===
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