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==Population== | ==Population== | ||
===Inclusion Criteria=== | ===Inclusion Criteria=== | ||
* ≥18 years of age | |||
* Mechanical ventilation | |||
* | * strong clinical suspicion of infection | ||
* ≥2 SIRS criteria <ref>{{#pmid:1303622}}</ref> | |||
* Continuous vasopressors/inotropes for SBP >90mmHg or MAP >60mmHg for ≥4 hours | |||
===Exclusion Criteria=== | ===Exclusion Criteria=== | ||
* Receiving systemic corticosteroids for indication other than septic shock | |||
* Received Etomidate | |||
* | * Receiving Amphotericin B for systemic fungal infection | ||
* Documented cerebral malaria | |||
* Documented strongyloides infection | |||
* Considered to suffer death within 90 days from pre-existing disease | |||
* Treatment limitations in place (i.e. DNR) | |||
* Met all inclusion criteria for longer than 24 hours | |||
===Baseline Characteristics=== | ===Baseline Characteristics=== | ||
''Hydrocortisone group displayed'' | |||
* Age,y: 62.3 ± 14.9 | |||
* | * Male: 60% | ||
* Weight, kg: 85.8 ± 26.6 | |||
* Medical Admission: 68% | |||
* Surgical admission: 31% | |||
* APACHE II score, median: 24 (IRQ: 19-29) | |||
* Therapy at baseline: | |||
** Mechanical ventilation: 99.8% | |||
** Inotropes / vasopressors: 99.5% | |||
*** Norepinepherine: 98.4% | |||
*** Vasopressin: 15.1% | |||
*** Epinepherine: 7.2% | |||
*** Other: 8.5% | |||
** Antimicrobial therapy: 98.3% | |||
** Renal-replacement therapy: 12.3% | |||
* MAP: 72.5 ± 8.2 | |||
* Primary site of infection: | |||
** Pulmonary: 39% | |||
** Abdominal: 26% | |||
** Blood: 17% | |||
** Skin/Soft tissue: 7% | |||
** Urinary: 8% | |||
** Other: 8% | |||
* Time from ICU admission to randomization, h: 26.1 ± 70.7 | |||
* Time from shock onset to randomization, h: 20.9 ± 91.9 | |||
==Interventions== | ==Interventions== | ||