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APROCCHSS: Difference between revisions
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==Population== | ==Population== | ||
===Inclusion Criteria=== | ===Inclusion Criteria=== | ||
< | * admitted to the ICU < 7 days | ||
* indisputable or probable septic shock < 24 hours | |||
* | ** presence of a clinically or microbiologically documented infection | ||
** SOFA<ref>{{#pmid:9824069}}</ref> score of 3-4 for ≥ 2 organ systems for ≥ 6 consecutive hours | |||
** receipt of vasopressor therapy (norepinephrine, epinephrine, or any other vasopressor at a dose of ≥ 0.25 mcg/kg/min or ≥ 1 mg per hour) for ≥ 6 hours to maintain SBP ≥ 90 mm Hg or MAP ≥ 65 mm Hg | |||
===Exclusion Criteria=== | ===Exclusion Criteria=== | ||
* septic shock > 24 hours | |||
* high risk of bleeding | |||
* | * pregnancy or lactation | ||
* underlying conditions that could affect short-term survival | |||
* known hypersensitivity to drotrecogin alfa (activated) | |||
* previous treatment with corticosteroids | |||
===Baseline Characteristics=== | ===Baseline Characteristics=== | ||
| Line 78: | Line 83: | ||
* Labs: | * Labs: | ||
* Site of infection | * Site of infection | ||
* | * | ||
==Interventions== | ==Interventions== | ||