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==Interventions== | ==Interventions== | ||
< | 2x2 factorial design: | ||
* Hydrocortisone 50mg IV every 6 hours and fludrocortisone 50 mcg NG daily for 7 days without taper | |||
* | * Activated proteine C 24 mcg/kg/h for 96 h<ref name=APC/> | ||
* Placebo (mannitol 133.6 mg IV and microsrystalline cellulose 50 mg) | |||
==Outcomes== | ==Outcomes== |
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