ConSEPT

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Dalziel SR. "Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial.". Lancet. 2019. 393(10186):2135-2145.
PubMed

Clinical Question

Bottom Line

Major Points

Guidelines

As of June 2018, no guidelines have been published that reflect the results of this trial.

Design

  • Multicenter, double-blind, parallel-group, randomized, controlled trial
  • N=
    • Intervention (n=)
    • Placebo (n=)
  • Setting:
  • Enrollment:
  • Mean follow-up:
  • Analysis:
  • Primary Outcome:

Population

Inclusion Criteria

Exclusion Criteria

Baseline Characteristics

BLANK Group displayed

  • Demographics:
  • Physiologic parameters:
  • Anthropomorphics: Weight
  • Labs:
  • Site of infection

Interventions

Outcomes

Comparisons are BLANK therapy vs. BLANK therapy.

Primary Outcomes

Secondary Outcomes

Subgroup Analysis

Adverse Events

Criticisms

Funding

  • Health Research Council of New Zealand
  • A+ Trust
  • Emergency Medicine Foundation
  • Townsville Hospital Private Practice Fund
  • Eric Ormond Baker Charitable Fund
  • Princess Margaret Hospital Foundation

Further Reading