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{
"articlesQuery" : {
"topic" : "all",
"articles" : [
{
"timestamp" : "2019-09-12T17:46:55Z",
"briefDesignDescription" : "Antibiotic strategies in lower respiratory tract infections",
"fulltexturl" : "https://www.bmj.com/content/357/bmj.j2148.long",
"pageid" : 2956,
"pdfurl" : "https://www.bmj.com/content/bmj/357/bmj.j2148.full.pdf",
"trainingLevel" : "Resident",
"citation" : "Little P, et al. \"Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study\". The British Medical Journal. 2017. 357:j2148.",
"subspecialties" : "Infectious Disease;Pulmonology",
"expansion" : "Cough Complication Cohort",
"statusUsableDate" : "2019-09-12",
"briefResultsDescription" : "Similar outcomes in upfront, delayed, and no antibiotic strategies",
"published" : "2017-05-22",
"pageName" : "3C",
"diseases" : "Pneumonia",
"abbreviation" : "3C",
"title" : "Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study",
"pmid" : "28533265"
},
{
"timestamp" : "2017-12-03T22:32:58Z",
"briefDesignDescription" : "Central line complications by insertion site",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500964",
"pageid" : 2479,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500964",
"trainingLevel" : "Student",
"citation" : "Parienti JJ, et al. \"Intravascular Complications of Central Venous Catheterization by Insertion Site\". The New England Journal of Medicine. 2015. 373(13):1220-1229.",
"subspecialties" : "Critical Care;Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2015-11-01",
"briefResultsDescription" : "Subclavian lines yield fewer CRBSIs and DVTs compared to IJ/femoral lines",
"published" : "2015-09-24",
"pageName" : "3SITES",
"diseases" : "Critical Illness;Catheter-Related Bloodstream Infection",
"abbreviation" : "3SITES",
"title" : "Intravascular Complications of Central Venous Catheterization by Insertion Site",
"pmid" : "26398070"
},
{
"timestamp" : "2017-12-14T19:22:25Z",
"briefDesignDescription" : "Simvastatin in stable CAD",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)90566-5/abstract",
"pageid" : 1587,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "Pedersen TR, et al. \"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)\". The Lancet. 1994. 344(8934):1383-1389.",
"subspecialties" : "Cardiology",
"expansion" : "Scandinavian Simvastatin Survival Study",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Simvastatin reduces all mortality in stable CAD",
"published" : "1994-11-19",
"pageName" : "4S",
"diseases" : "Hyperlipidemia;Coronary Artery Disease",
"abbreviation" : "4S",
"title" : "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)",
"pmid" : "7968073"
},
{
"timestamp" : "2021-08-21T01:56:39Z",
"briefDesignDescription" : "MAP 60-65 vs. usual care in vasodilatory hypotension in ICU",
"fulltexturl" : "https://doi.org/10.1001/jama.2020.0930",
"pageid" : 4436,
"pdfurl" : "",
"trainingLevel" : "resident",
"citation" : "Lamontagne F, et al. \"Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension; A Randomized Clinical Trial\". JAMA. 2020. 323(10):938-949.",
"subspecialties" : "Critical Care;Neurology;Geriatrics",
"expansion" : "",
"statusUsableDate" : "2021-08-19",
"briefResultsDescription" : "No difference in mortality between groups",
"published" : "2020-02-12",
"pageName" : "65 Trial",
"diseases" : "Hypotension",
"abbreviation" : "65 Trial",
"title" : "Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension; A Randomized Clinical Trial",
"pmid" : "32049269"
},
{
"timestamp" : "2019-02-22T06:12:34Z",
"briefDesignDescription" : "ISDN/hydralazine for black patients with HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa042934",
"pageid" : 41,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa042934",
"trainingLevel" : "Student",
"citation" : "Taylor AL, et al. \"Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure\". The New England Journal of Medicine. 2004. 351(20):2049-2057.",
"subspecialties" : "Cardiology",
"expansion" : "African-American Heart Failure Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Improved survival among black patients with HF",
"published" : "2004-11-11",
"pageName" : "A-HeFT",
"diseases" : "Heart Failure",
"abbreviation" : "A-HeFT",
"title" : "Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure",
"pmid" : "15533851"
},
{
"timestamp" : "2019-10-29T18:24:45Z",
"briefDesignDescription" : "BP management for CKD in African Americans",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/195530",
"pageid" : 2666,
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/195530/joc20772.pdf",
"trainingLevel" : "Intern",
"citation" : "Wright JT Jr., et al. \"Intensive blood-pressure control in hypertensive chronic kidney disease\". JAMA. 2002. 288(19):2421-2431.",
"subspecialties" : "Nephrology",
"expansion" : "African American Study of Kidney Disease and Hypertension",
"statusUsableDate" : "2019-08-29",
"briefResultsDescription" : "Intensive BP control didn't prevent progression of kidney disease but ACE-inhibitors did",
"published" : "2002-11-20",
"pageName" : "AASK",
"diseases" : "Chronic Kidney Disease;Hypertension",
"abbreviation" : "AASK",
"title" : "Intensive blood-pressure control in hypertensive chronic kidney disease",
"pmid" : "12435255"
},
{
"timestamp" : "2017-12-03T22:33:01Z",
"briefDesignDescription" : "AF ablation vs. amiodarone in HFrEF with LVEF ≤40%",
"fulltexturl" : "http://circ.ahajournals.org/content/early/2016/03/30/CIRCULATIONAHA.115.019406",
"pageid" : 2829,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Di Biase et al. \"Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device\". Circulation. 2016. 133(17):1637-1634.",
"subspecialties" : "Cardiology",
"expansion" : "Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device",
"statusUsableDate" : "2016-09-01",
"briefResultsDescription" : "AF ablation superior to amiodarone in HFrEF with LVEF ≤40%",
"published" : "2016-04-26",
"pageName" : "AATAC",
"diseases" : "Atrial Fibrillation;Heart Failure",
"abbreviation" : "AATAC",
"title" : "Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device",
"pmid" : "27029350"
},
{
"timestamp" : "2018-01-11T18:23:02Z",
"briefDesignDescription" : "Benazepril/amlodipine vs. benazepril/HCTZ in HTN",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0806182",
"pageid" : 1448,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0806182",
"trainingLevel" : "Resident",
"citation" : "Jamerson K, et al. \"Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients\". The New England Journal of Medicine. 2008. 359(23):2417-2428.",
"subspecialties" : "Cardiology",
"expansion" : "Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Benazepril/amlodipine is associated with fewer CV events",
"published" : "2008-12-04",
"pageName" : "ACCOMPLISH",
"diseases" : "Hypertension",
"abbreviation" : "ACCOMPLISH",
"title" : "Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients",
"pmid" : "19052124"
},
{
"timestamp" : "2019-12-18T14:23:33Z",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802743",
"pageid" : 105,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802743",
"trainingLevel" : "Intern",
"citation" : "Gerstein HC, et al. \"Effects of Intensive Glucose Lowering in Type 2 Diabetes\". The New England Journal of Medicine. 2008. 358(24):2545-59.",
"subspecialties" : "Endocrinology",
"expansion" : "Action to Control Cardiovascular Risk in Diabetes",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Increased mortality and no cardiovascular benefit with intensive glycemic control",
"published" : "2008-06-12",
"pageName" : "ACCORD",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "ACCORD",
"title" : "Effects of Intensive Glucose Lowering in Type 2 Diabetes",
"pmid" : "18539917"
},
{
"timestamp" : "2019-12-18T14:22:30Z",
"briefDesignDescription" : "Intensive BP control in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001286",
"pageid" : 1760,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001286",
"trainingLevel" : "Student",
"citation" : "ACCORD Study Group. \"Effects of intensive blood-pressure control in type 2 diabetes mellitus\". The New England Journal of Medicine. 2010. 362(17):1575-1585.",
"subspecialties" : "Endocrinology",
"expansion" : "ACCORD Study Group",
"statusUsableDate" : "2014-08-01",
"briefResultsDescription" : "Intensive BP control doesn't reduce CV events in T2DM",
"published" : "2010-03-14",
"pageName" : "ACCORD BP",
"diseases" : "Diabetes Mellitus;Hypertension",
"abbreviation" : "ACCORD BP",
"title" : "Effects of intensive blood-pressure control in type 2 diabetes mellitus",
"pmid" : "20228401"
},
{
"timestamp" : "2018-01-31T01:55:15Z",
"briefDesignDescription" : "Fibrate add-on to statins in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001282",
"pageid" : 3520,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001282",
"trainingLevel" : "Student",
"citation" : "ACCORD Study Group. \"Effects of combination lipid therapy in type 2 diabetes mellitus\". The New England Journal of Medicine. 2010. 362(17):1563-1574.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "Action to Control Cardiovascular Risk in Diabetes-Lipid",
"statusUsableDate" : "2018-01-17",
"briefResultsDescription" : "Fenofibrates don't reduce CVD among adults with T2DM on statins",
"published" : "2010-04-29",
"pageName" : "ACCORD Lipid",
"diseases" : "Diabetes Mellitus;Coronary Artery Disease;Stroke",
"abbreviation" : "ACCORD Lipid",
"title" : "Effects of combination lipid therapy in type 2 diabetes mellitus",
"pmid" : "20228404"
},
{
"timestamp" : "2024-03-28T17:22:37Z",
"briefDesignDescription" : "Empiric cefepime vs. pip-tazo for infection",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2810592",
"pageid" : 5478,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Qian E, et al. \"Cefepime vs. piperacillin-tazobactam in adults hospitalized with acute infection\". JAMA. 2023. 330(16):1557-1567.",
"subspecialties" : "Infectious Disease;Critical Care;Emergency Medicine",
"expansion" : "Antibiotic Choice on Renal Outcomes",
"statusUsableDate" : "2024-02-22",
"briefResultsDescription" : "Similar rates of AKI; cefepime causes more CNS toxicity",
"published" : "2023-10-14",
"pageName" : "ACORN",
"diseases" : "Infection",
"abbreviation" : "ACORN",
"title" : "Cefepime vs. piperacillin-tazobactam in adults hospitalized with acute infection",
"pmid" : "37837651"
},
{
"timestamp" : "2018-09-06T17:17:42Z",
"briefDesignDescription" : "ALND in SLND-positive breast cancer",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/645514",
"pageid" : 3545,
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/645514/joc15004_569_575.pdf",
"trainingLevel" : "Fellow",
"citation" : "Giuliano AE, et al. \"Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial\". The Journal of the American Medical Association. 2011. 305(6):569-575.",
"subspecialties" : "Oncology;Surgery",
"expansion" : "The American College of Surgeons Oncology Group (ACOSOG) Z0011",
"statusUsableDate" : "2018-09-06",
"briefResultsDescription" : "ALND no better than monitoring in SLNB-positive disease",
"published" : "2011-02-09",
"pageName" : "ACOSOG Z0011",
"diseases" : "Breast Cancer",
"abbreviation" : "ACOSOG Z0011",
"title" : "Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial",
"pmid" : "21304082"
},
{
"timestamp" : "2017-12-03T22:33:07Z",
"briefDesignDescription" : "Acetylcysteine with IV contrast",
"fulltexturl" : "http://circ.ahajournals.org/cgi/pmidlookup?view",
"pageid" : 2425,
"pdfurl" : "http://circ.ahajournals.org/content/124/11/1250.full.pdf",
"trainingLevel" : "Intern",
"citation" : "ACT Investigators. \"Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography\". Circulation. 2011. 124:1250-1259.",
"subspecialties" : "Nephrology;Cardiology",
"expansion" : "Acetylcysteine for Contrast-Induced Nephropathy Trial",
"statusUsableDate" : "2015-08-01",
"briefResultsDescription" : "Acetylcysteine doesn't prevent contrast-induced acute kidney injury",
"published" : "2011-06-28",
"pageName" : "ACT",
"diseases" : "Acute Kidney Injury;Acute Coronary Syndrome",
"abbreviation" : "ACT",
"title" : "Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography",
"pmid" : "21859972"
},
{
"timestamp" : "2023-02-03T04:55:43Z",
"briefDesignDescription" : "Carotid stenting vs. endarterectomy",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1515706",
"pageid" : 2721,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1515706",
"trainingLevel" : "Resident",
"citation" : "Rosenfield K, et al. \"Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis\". The New England Journal of Medicine. 2016. 374(11):1011-20.",
"subspecialties" : "Cardiology",
"expansion" : "Stent versus endarterectomy for asymptomatic carotid stenosis",
"statusUsableDate" : "2023-02-01",
"briefResultsDescription" : "Carotid stenting noninferior to endarterectomy in asymptomatic carotid stenosis",
"published" : "2016-02-17",
"pageName" : "ACT I",
"diseases" : "Carotid Stenosis",
"abbreviation" : "ACT I",
"title" : "Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis",
"pmid" : "26886419"
},
{
"timestamp" : "2017-12-03T22:33:09Z",
"briefDesignDescription" : "ASA/clopidogrel vs. ASA in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0901301",
"pageid" : 360,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0901301",
"trainingLevel" : "Resident",
"citation" : "Connolly SJ, et al. \"Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2009. 360(20):2066-78.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "ASA/clopidogrel ↓ composite of stroke, non-CNS embolism, MI, or CV death and ↑ bleeding",
"published" : "2009-05-14",
"pageName" : "ACTIVE A",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"abbreviation" : "ACTIVE A",
"title" : "Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation",
"pmid" : "19336502"
},
{
"timestamp" : "2017-12-03T22:33:10Z",
"briefDesignDescription" : "ASA/clopidogrel vs. warfarin in AF",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)68845-4",
"pageid" : 1438,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606688454.pdf",
"trainingLevel" : "Intern",
"citation" : "Connolly SJ, et al. \"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.\". The Lancet. 2006. 367(9526):1903-12.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "Warfarin is superior to ASA/clopidogrel for stroke prevention in AF",
"published" : "2006-06-10",
"pageName" : "ACTIVE W",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"abbreviation" : "ACTIVE W",
"title" : "Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.",
"pmid" : "16765759"
},
{
"timestamp" : "2020-07-02T17:55:05Z",
"briefDesignDescription" : "Remdesivir vs. placebo in Covid-19",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2007764",
"pageid" : 4238,
"pdfurl" : "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262788/pdf/NEJMoa2007764.pdf",
"trainingLevel" : "Student",
"citation" : "Beigel JH, et al. \"Remdesivir for the Treatment of Covid-19 - Preliminary Report\". The New England Journal of Medicine. 2020. 1-12.",
"subspecialties" : "Infectious Disease",
"expansion" : "Adaptive Covid-19 Treatment Trial",
"statusUsableDate" : "2020-06-30",
"briefResultsDescription" : "Remdesivir modestly shortens time to recovery mostly in severe disease",
"published" : "2020-05-22",
"pageName" : "ACTT-1",
"diseases" : "Covid-19",
"abbreviation" : "ACTT-1",
"title" : "Remdesivir for the Treatment of Covid-19 - Preliminary Report",
"pmid" : "32445440"
},
{
"timestamp" : "2019-06-05T22:43:36Z",
"briefDesignDescription" : "Cisatracurium in ARDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005372",
"pageid" : 1119,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005372",
"trainingLevel" : "resident",
"citation" : "Papazian L, et al. \"Neuromuscular blockers in early acute respiratory distress syndrome\". The New England Journal of Medicine. 2010. 363(12):1107-1116.",
"subspecialties" : "Critical Care",
"expansion" : "ARDS et Curarisation Systematique",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Cisatracurium improves 90-day survival and increases ventilator-free days",
"published" : "2010-09-16",
"pageName" : "ACURASYS",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "ACURASYS",
"title" : "Neuromuscular blockers in early acute respiratory distress syndrome",
"pmid" : "20843245"
},
{
"timestamp" : "2021-12-19T22:24:03Z",
"briefDesignDescription" : "Age-adjusted D-dimer for PE",
"fulltexturl" : "http://bit.ly/1QgJ5k1",
"pageid" : 2367,
"pdfurl" : "http://bit.ly/1HTY4kQ",
"trainingLevel" : "Resident",
"citation" : "Righini M, et al. \"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study\". JAMA. 2014. 311(11):1117-1124.",
"subspecialties" : "Hematology;Emergency Medicine",
"expansion" : "Age aDJUSTed D-Dimer to rule out PE",
"statusUsableDate" : "2015-05-01",
"briefResultsDescription" : "Age-adjusted D-dimer (age × 10 in patients >50) rules out PE",
"published" : "2014-03-19",
"pageName" : "ADJUST-PE",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "ADJUST-PE",
"title" : "Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study",
"pmid" : "24643601"
},
{
"timestamp" : "2018-02-08T17:58:17Z",
"briefDesignDescription" : "Hydrocortisone in septic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1705835",
"pageid" : 3528,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1705835",
"trainingLevel" : "Resident",
"citation" : "Venkatesh B, et al. \"Adjunctive glucocorticoid therapy in patients with septic shock\". New England Journal of Medicine. 2018. Epub 2018-01-19:1-12.",
"subspecialties" : "Critical Care",
"expansion" : "Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock",
"statusUsableDate" : "2018-02-08",
"briefResultsDescription" : "Hydrocortisone provides no benefit in 90-day mortality",
"published" : "2018-01-19",
"pageName" : "ADRENAL",
"diseases" : "Sepsis;Shock",
"abbreviation" : "ADRENAL",
"title" : "Adjunctive glucocorticoid therapy in patients with septic shock",
"pmid" : "29347874"
},
{
"timestamp" : "2014-09-19T13:02:39Z",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802987",
"pageid" : 248,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802987",
"trainingLevel" : "Intern",
"citation" : "Patel A, et al. \"Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes\". The New England Journal of Medicine. 2008. 358(24):2560-2572.",
"subspecialties" : "Endocrinology",
"expansion" : "Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Intensive therapy reduces microvascular complications",
"published" : "2008-06-06",
"pageName" : "ADVANCE",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "ADVANCE",
"title" : "Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes",
"pmid" : "18539916"
},
{
"timestamp" : "2022-12-20T15:19:03Z",
"briefDesignDescription" : "Acetazolamide vs. placebo in acute HF",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2203094",
"pageid" : 4655,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2203094",
"trainingLevel" : "Student",
"citation" : "Mullens W, et al. \"Acetazolamide in Acute Decompensated Heart Failure with Volume Overload\". NEJM. 2022. Epub 2022-08-27:1-11.",
"subspecialties" : "Cardiology;Emergency Medicine;Critical Care",
"expansion" : "Acetazolamide in Decompensated Heart Failure With Volume OveRload",
"statusUsableDate" : "2022-09-15",
"briefResultsDescription" : "Acetazolamide improves diuresis in acute HF",
"published" : "2022-08-27",
"pageName" : "ADVOR",
"diseases" : "Heart Failure",
"abbreviation" : "ADVOR",
"title" : "Acetazolamide in Acute Decompensated Heart Failure with Volume Overload",
"pmid" : "36027559"
},
{
"timestamp" : "2018-12-21T13:20:11Z",
"briefDesignDescription" : "Rhythm control for AF in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0708789",
"pageid" : 2800,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0708789",
"trainingLevel" : "Resident",
"citation" : "Roy D, et al. \"Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure\". The New England Journal of Medicine. 2008. 358(25):2667-2677.",
"subspecialties" : "Cardiology",
"expansion" : "Atrial Fibrillation and Congestive Heart Failure",
"statusUsableDate" : "2018-12-07",
"briefResultsDescription" : "Rhythm control does not reduce CV mortality in AF with HF",
"published" : "2008-06-19",
"pageName" : "AF-CHF",
"diseases" : "Heart Failure",
"abbreviation" : "AF-CHF",
"title" : "Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure",
"pmid" : "18565859"
},
{
"timestamp" : "2022-10-24T12:25:43Z",
"briefDesignDescription" : "Rate vs. rhythm control in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021328",
"pageid" : 87,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021328",
"trainingLevel" : "Student",
"citation" : "Wyse DG, et al. \"A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2002. 347(23):1825-1833.",
"subspecialties" : "Cardiology",
"expansion" : "Atrial Fibrillation Follow-up Investigation of Rhythm Management",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No mortality difference, trend towards harm with rhythm control",
"published" : "2002-11-05",
"pageName" : "AFFIRM",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "AFFIRM",
"title" : "A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation",
"pmid" : "12466506"
},
{
"timestamp" : "2017-12-03T22:33:43Z",
"briefDesignDescription" : "Mammograms for 40-49 year old women",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)69834-6",
"pageid" : 2307,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "Moss SM, et al. \"Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial\". The Lancet. 2006. 368(9552):2053-2060.",
"subspecialties" : "Oncology;Preventive Medicine",
"expansion" : "",
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Mammograms don't reduce breast cancer mortality in age 40-49 year old women",
"published" : "2006-12-09",
"pageName" : "Age Trial",
"diseases" : "Breast Cancer",
"abbreviation" : "Age Trial",
"title" : "Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial",
"pmid" : "17161727"
},
{
"timestamp" : "2023-01-15T01:17:39Z",
"briefDesignDescription" : "Haloperidol for ICU delirium",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2211868",
"pageid" : 5131,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2211868",
"trainingLevel" : "resident",
"citation" : "Andersen-Ranberg NC, et al. \"Haloperidol for the Treatment of Delirium in ICU Patients\". The New England Journal of Medicine. 2022. Online ahead of print(2022-10-26):1-11.",
"subspecialties" : "Critical Care",
"expansion" : "Agents Intervening against Delirium in the Intensive Care Unit",
"statusUsableDate" : "2022-11-02",
"briefResultsDescription" : "Haloperidol does not improve days alive out of hospital",
"published" : "2022-10-26",
"pageName" : "AID-ICU",
"diseases" : "Delirium",
"abbreviation" : "AID-ICU",
"title" : "Haloperidol for the Treatment of Delirium in ICU Patients",
"pmid" : "36286254"
},
{
"timestamp" : "2017-12-03T22:33:14Z",
"briefDesignDescription" : "Scaffold vs. stent in PCI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1614954",
"pageid" : 2940,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1614954",
"trainingLevel" : "Resident",
"citation" : "Wykrzykowska JJ et al. \"Bioresorbable scaffolds versus metallic stents in routine PCI\". The New England Journal of Medicine. 2017. 376(24):2319-2328.",
"subspecialties" : "Cardiology",
"expansion" : "Amsterdam Investigator-Initiated Absorb Strategy All-Comers Trial",
"statusUsableDate" : "2017-06-01",
"briefResultsDescription" : "Scaffold inferior to stent in PCI",
"published" : "2017-06-14",
"pageName" : "AIDA",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "AIDA",
"title" : "Bioresorbable scaffolds versus metallic stents in routine PCI",
"pmid" : "28402237"
},
{
"timestamp" : "2018-10-16T05:18:00Z",
"briefDesignDescription" : "Anakinra in colchicine-resistant pericarditis",
"fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2579869",
"pageid" : 2865,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Brucato A, et al. \"Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence\". Journal of the American Medical Association. 2016. 316(18):1906-1912.",
"subspecialties" : "Cardiology",
"expansion" : "AnakInRa for Treatment of Recurrent Idiopathic Pericarditis",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "Anakinra superior to placebo in colchicine resistant, steroid-dependent pericarditis",
"published" : "2016-11-08",
"pageName" : "AIRTRIP",
"diseases" : "Pericarditis",
"abbreviation" : "AIRTRIP",
"title" : "Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence",
"pmid" : "27825009"
},
{
"timestamp" : "2019-03-27T18:29:53Z",
"briefDesignDescription" : "Early vs. late RRT in severe AKI in ICU",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603017",
"pageid" : 2937,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603017",
"trainingLevel" : "Resident",
"citation" : "Gaudry S, et al. \"Initiation strategies for renal-replacement therapy in the intensive care unit\". The New England Journal of Medicine. 2016. 375(2):122-133.",
"subspecialties" : "Critical Care;Nephrology",
"expansion" : "Artificial Kidney Initiation in Kidney Injury",
"statusUsableDate" : "2017-08-01",
"briefResultsDescription" : "No mortality difference between early or delayed RRT in ICU patients with AKI",
"published" : "2016-07-14",
"pageName" : "AKIKI",
"diseases" : "Acute Kidney Injury",
"abbreviation" : "AKIKI",
"title" : "Initiation strategies for renal-replacement therapy in the intensive care unit",
"pmid" : "27181456"
},
{
"timestamp" : "2018-07-03T03:04:07Z",
"briefDesignDescription" : "Daily albumin in severe sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305727",
"pageid" : 1781,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1305727",
"trainingLevel" : "resident",
"citation" : "Caironi P, et al. \"Albumin replacement in patients with severe sepsis or septic shock\". The New England Journal of Medicine. 2014. 370(15):1412-1421.",
"subspecialties" : "Critical Care",
"expansion" : "Albumin Italian Outcome Sepsis",
"statusUsableDate" : "2014-03-01",
"briefResultsDescription" : "Daily albumin with no mortality benefit at 28 days",
"published" : "2014-03-18",
"pageName" : "ALBIOS",
"diseases" : "Sepsis",
"abbreviation" : "ALBIOS",
"title" : "Albumin replacement in patients with severe sepsis or septic shock",
"pmid" : "24635772"
},
{
"timestamp" : "2017-12-03T22:33:45Z",
"briefDesignDescription" : "Albumin for SBP in cirrhosis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199908053410603",
"pageid" : 2501,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199908053410603",
"trainingLevel" : "Intern",
"citation" : "Sort P, et al. \"Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis\". The New England Journal of Medicine. 1999. 341(6):403-409.",
"subspecialties" : "Gastroenterology;Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2017-09-01",
"briefResultsDescription" : "Albumin reduces AKI and mortality in SBP in cirrhosis",
"published" : "1999-08-05",
"pageName" : "Albumin for SBP",
"diseases" : "Spontaneous Bacterial Peritonitis;Cirrhosis",
"abbreviation" : "",
"title" : "Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis",
"pmid" : "10432325"
},
{
"timestamp" : "2018-09-14T00:37:12Z",
"briefDesignDescription" : "Chlorthalidone in HTN",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/vol/288/pg/2981",
"pageid" : 171,
"pdfurl" : null,
"trainingLevel" : "Student",
"citation" : "Wright JT, et al. \"Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs. Diuretic\". Journal of the American Medical Association. 2002. 288(23):2981-2997.",
"subspecialties" : "Nephrology;Cardiology",
"expansion" : "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Chlorthalidone performs similarly to lisinopril and amlodipine",
"published" : "2002-12-18",
"pageName" : "ALLHAT",
"diseases" : "Hypertension",
"abbreviation" : "ALLHAT",
"title" : "Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs. Diuretic",
"pmid" : "12479763"
},
{
"timestamp" : "2020-11-11T16:18:38Z",
"briefDesignDescription" : "Pravastatin vs usual care for ASCVD primary prevention",
"fulltexturl" : "http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2628971",
"pageid" : 2949,
"pdfurl" : "http://www.natap.org/2017/HIV/jamainternal_Han_2017_oi_170031.pdf",
"trainingLevel" : "Intern",
"citation" : "Han BH, et al. \"Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial\". JAMA Internal Medicine. 2017. 177(7):955-965.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2020-11-20",
"briefResultsDescription" : "Pravastatin does not decrease mortality",
"published" : "2017-07-01",
"pageName" : "ALLHAT-LLT Elderly",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "ALLHAT-LLT",
"title" : "Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial",
"pmid" : "28531241"
},
{
"timestamp" : "2018-02-04T17:46:37Z",
"briefDesignDescription" : "MMF vs. CTX in lupus nephritis",
"fulltexturl" : "http://jasn.asnjournals.org/content/20/5/1103.long",
"pageid" : 2655,
"pdfurl" : "http://jasn.asnjournals.org/content/20/5/1103.full.pdf",
"trainingLevel" : "Resident",
"citation" : "Appel GB, et al. \"Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.\". Journal of American Society of Nephrology. 2009. 20(5):1103–1112.",
"subspecialties" : "Nephrology;Rheumatology",
"expansion" : "Aspreva Lupus Management Study",
"statusUsableDate" : "2017-11-01",
"briefResultsDescription" : "MMF similar to cyclophosphamide in lupus nephritis",
"published" : "2009-05-01",
"pageName" : "ALMS",
"diseases" : "Lupus Nephritis;Lupus",
"abbreviation" : "ALMS",
"title" : "Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.",
"pmid" : "19369404"
},
{
"timestamp" : "2020-07-02T15:32:34Z",
"briefDesignDescription" : "Azithromycin in chronic asthma",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(17)31281-3",
"pageid" : 3615,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Gibson PG, et al. \"Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): A randomised, double-blind, placebo-controlled trial\". Lancet. 2017. 390(10095):659-668.",
"subspecialties" : "Pulmonology",
"expansion" : "Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma",
"statusUsableDate" : "2020-06-29",
"briefResultsDescription" : "Athithromycin reduced rate of exacerbations and improved QOL",
"published" : "2017-08-12",
"pageName" : "AMAZES",
"diseases" : "Asthma",
"abbreviation" : "AMAZES",
"title" : "Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): A randomised, double-blind, placebo-controlled trial",
"pmid" : "28687413"
},
{
"timestamp" : "2023-06-22T19:17:55Z",
"briefDesignDescription" : "Apixaban vs. warfarin in VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1302507",
"pageid" : 1609,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302507",
"trainingLevel" : "Intern",
"citation" : "Agnelli G, et al. \"Oral apixaban for the treatment of acute venous thromboembolism\". The New England Journal of Medicine. 2013. 369(9):799-808.",
"subspecialties" : "Hematology;Pulmonology",
"expansion" : "Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Apixaban noninferior to warfarin for VTE recurrence; less bleeding",
"published" : "2013-07-01",
"pageName" : "AMPLIFY",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"abbreviation" : "AMPLIFY",
"title" : "Oral apixaban for the treatment of acute venous thromboembolism",
"pmid" : "23808982"
},
{
"timestamp" : "2023-04-19T12:49:42Z",
"briefDesignDescription" : "Apixaban after VTE treatment",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1207541",
"pageid" : 1245,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1207541",
"trainingLevel" : "Resident",
"citation" : "Agnelli G, et al. \"Apixaban for extended treatment of venous thromboembolism\". The New England Journal of Medicine. 2013. 368(8):699-708.",
"subspecialties" : "Hematology",
"expansion" : "Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy-Extended Treatment",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "Apixaban reduces recurrent VTE",
"published" : "2013-02-21",
"pageName" : "AMPLIFY-EXT",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "AMPLIFY-EXT",
"title" : "Apixaban for extended treatment of venous thromboembolism",
"pmid" : "23216615"
},
{
"timestamp" : "2020-03-17T17:50:15Z",
"briefDesignDescription" : "Corticosteroids in septic shock",
"fulltexturl" : "http://jama.jamanetwork.com/article.aspx?articleid",
"pageid" : 939,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4844/JCE10061.pdf",
"trainingLevel" : "Resident",
"citation" : "Annane D, et al. \"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock\". Journal of the American Medical Association. 2002. 288(7):862-871.",
"subspecialties" : "Critical Care",
"expansion" : "",
"statusUsableDate" : "2013-02-01",
"briefResultsDescription" : "Corticosteroids reduce mortality in septic shock with adrenal insufficiency",
"published" : "2002-08-21",
"pageName" : "Annane Trial",
"diseases" : "Sepsis;Shock",
"abbreviation" : "Ger-Inf-05",
"title" : "Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock",
"pmid" : "12186604"
},
{
"timestamp" : "2018-07-11T03:22:16Z",
"briefDesignDescription" : "Andexanet for reversing Xa inhibitors",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1510991",
"pageid" : 2502,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510991",
"trainingLevel" : "Resident",
"citation" : "Siegal DM, et al. \"Andexanet alfa for the reversal of factor Xa inhibitor activity\". The New England Journal of Medicine. 2015. 373(25):2413-2424.",
"subspecialties" : "Hematology",
"expansion" : "Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors",
"statusUsableDate" : "2017-03-01",
"briefResultsDescription" : "Andexanet reverses Xa inhibitors",
"published" : "2015-12-17",
"pageName" : "ANNEXA",
"diseases" : "Hemorrhage",
"abbreviation" : "ANNEXA",
"title" : "Andexanet alfa for the reversal of factor Xa inhibitor activity",
"pmid" : "26559317"
},
{
"timestamp" : "2019-03-07T17:07:14Z",
"briefDesignDescription" : "Andexanet alfa for factor Xa inhibitor reversal",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1607887",
"pageid" : 3641,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1607887",
"trainingLevel" : "Resident",
"citation" : "Connolly SJ, et al. \"Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors\". The New England Journal of Medicine. 2016. 375(12):1131-1141.",
"subspecialties" : "Hematology;Emergency Medicine;Cardiology",
"expansion" : "Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of Factor Xa Inhibitors",
"statusUsableDate" : "2019-02-07",
"briefResultsDescription" : "Andexanet alfa achieved hemostasis in 80%",
"published" : "2016-09-22",
"pageName" : "ANNEXA-4",
"diseases" : "Hemorrhage",
"abbreviation" : "ANNEXA-4",
"title" : "Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors",
"pmid" : "27573206"
},
{
"timestamp" : "2017-12-03T22:33:27Z",
"briefDesignDescription" : "Pre-exposure prophylaxis in high-risk men",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506273",
"pageid" : 2649,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506273",
"trainingLevel" : "Student",
"citation" : "Molina JM, et al. \"On-demand preexposure prophylaxis in men at high risk for HIV-1 infection\". The New England Journal of Medicine. 2015. 373(23):2237-2246.",
"subspecialties" : "Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2015-12-01",
"briefResultsDescription" : "Pre-exposure prophylaxis reduces HIV transmission in high-risk men",
"published" : "2015-12-03",
"pageName" : "ANRS IPERGAY",
"diseases" : "HIV",
"abbreviation" : "ANRS IPERGAY",
"title" : "On-demand preexposure prophylaxis in men at high risk for HIV-1 infection",
"pmid" : "26624850"
},
{
"timestamp" : "2016-04-01T23:26:41Z",
"briefDesignDescription" : "Ceftriaxone vs. norfloxacin in cirrhotics with GI bleed",
"fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/fulltext",
"pageid" : 82,
"pdfurl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/pdf",
"trainingLevel" : "Intern",
"citation" : "Fernández J, et al. \"Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage\". Gastroenterology. 2006. 131(4):1049-56.",
"subspecialties" : "Gastroenterology;Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Ceftriaxone reduces the incidence of bacterial infection",
"published" : "2006-10-01",
"pageName" : "Antibiotics in Cirrhosis with Hemorrhage",
"diseases" : "Cirrhosis;Gastrointestinal Hemorrhage",
"abbreviation" : "",
"title" : "Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage",
"pmid" : "17030175"
},
{
"timestamp" : "2021-10-08T13:12:27Z",
"briefDesignDescription" : "Maintenance vs. discontinuation of antidepressants",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2106356",
"pageid" : 4441,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2106356",
"trainingLevel" : "student",
"citation" : "Lewis G, et al. \"Maintenance or discontinuation of antidepressants in primary care\". The New England Journal of Medicine. 2021. 385(14):1257-1267.",
"subspecialties" : "Psychiatry",
"expansion" : "Antidepressants to Prevent Relapse in Depression",
"statusUsableDate" : "2021-09-30",
"briefResultsDescription" : "Maintenance of antidepressants associated with less depression relapse",
"published" : "2021-09-30",
"pageName" : "ANTLER",
"diseases" : "Depression",
"abbreviation" : "ANTLER",
"title" : "Maintenance or discontinuation of antidepressants in primary care",
"pmid" : "34587384"
},
{
"timestamp" : "2018-11-15T17:21:28Z",
"briefDesignDescription" : "Betrixaban for extended VTE prophylaxis",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1601747",
"pageid" : 3713,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1601747",
"trainingLevel" : "resident",
"citation" : "Cohen AT, et al. \"Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients\". The New England Journal of Medicine. 2016. 375(6):534-44.",
"subspecialties" : "Hematology",
"expansion" : "Acutely Medically Ill VTE Prevention with Extended Duration Betrixaban",
"statusUsableDate" : "2018-11-15",
"briefResultsDescription" : "Betrixaban did not meet its primary endpoint",
"published" : "2017-08-27",
"pageName" : "APEX",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "APEX",
"title" : "Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients",
"pmid" : "27232649"
},
{
"timestamp" : "2019-01-03T23:02:05Z",
"briefDesignDescription" : "Antibiotics vs. surgery for acute appendicitis",
"fulltexturl" : "https://jamanetwork.com/journals/jama/article-abstract/2703354",
"pageid" : 3539,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Salminen P, et al. \"Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial\". JAMA. 2018. 320(12):1259-1265.",
"subspecialties" : "Surgery;Infectious Disease",
"expansion" : "Appendicitis Acuta",
"statusUsableDate" : "2018-07-26",
"briefResultsDescription" : "Antibiotics not non-inferior to surgeyr",
"published" : "2015-06-16",
"pageName" : "APPAC",
"diseases" : "Appendicitis",
"abbreviation" : "AAPAC",
"title" : "Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial",
"pmid" : "26080338"
},
{
"timestamp" : "2021-04-08T18:21:59Z",
"briefDesignDescription" : "Steroids in septic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1705716",
"pageid" : 3551,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1705716",
"trainingLevel" : "Resident",
"citation" : "Annane D, et al. \"Hydrocortisone plus Fludrocortisone for Adults with Septic Shock\". The New England Journal of Medicine. 2018. 378(9):809-818.",
"subspecialties" : "Critical Care",
"expansion" : "Recombinant Human Activated Protein C and Low Dose of Hydrocortisone and Fludrocortisone in Adult Septic Shock",
"statusUsableDate" : "2021-03-30",
"briefResultsDescription" : "Hydrocortisone plus fludrocortisone improved survival in septic shock",
"published" : "2018-03-01",
"pageName" : "APROCCHSS",
"diseases" : "Sepsis",
"abbreviation" : "APROCCHSS",
"title" : "Hydrocortisone plus Fludrocortisone for Adults with Septic Shock",
"pmid" : "29490185"
},
{
"timestamp" : "2021-02-23T14:31:34Z",
"briefDesignDescription" : "Low vs. traditional volumes in ARDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200005043421801",
"pageid" : 114,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200005043421801",
"trainingLevel" : "Intern",
"citation" : "Brower RG, et al. \"Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome\". The New England Journal of Medicine. 2000. 342(18):1301-1308.",
"subspecialties" : "Critical Care",
"expansion" : "Acute Respiratory Distress Syndrome Network",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit and more ventilator-free days with lung-protective strategy",
"published" : "2000-05-04",
"pageName" : "ARDSNet",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "ARDSNet",
"title" : "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome",
"pmid" : "10793162"
},
{
"timestamp" : "2017-12-03T22:33:28Z",
"briefDesignDescription" : "EGDT vs. usual care in sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1404380",
"pageid" : 2216,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1404380",
"trainingLevel" : "Intern",
"citation" : "ARISE and ANZICS writers. \"Goal-directed resuscitation for patients with early septic shock\". The New England Journal of Medicine. 2014. 371(16):1496-1506.",
"subspecialties" : "Critical Care",
"expansion" : "Australasian Resuscitation in Sepsis Evaluation",
"statusUsableDate" : "2014-11-01",
"briefResultsDescription" : "EGDT doesn't reduce mortality in sepsis",
"published" : "2014-10-16",
"pageName" : "ARISE",
"diseases" : "Sepsis",
"abbreviation" : "ARISE",
"title" : "Goal-directed resuscitation for patients with early septic shock",
"pmid" : "25272316"
},
{
"timestamp" : "2018-03-29T18:55:04Z",
"briefDesignDescription" : "Apixaban vs. warfarin in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1107039",
"pageid" : 1497,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1107039",
"trainingLevel" : "Intern",
"citation" : "Granger CB, et al. \"Apixaban versus warfarin in patients with atrial fibrillation\". The New England Journal of Medicine. 2011. 365(11):981-982.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Apixaban better for CVA prevention in AF",
"published" : "2011-09-15",
"pageName" : "ARISTOTLE",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"abbreviation" : "ARISTOTLE",
"title" : "Apixaban versus warfarin in patients with atrial fibrillation",
"pmid" : "21870978"
},
{
"timestamp" : "2019-08-02T19:20:32Z",
"briefDesignDescription" : "Rifampin in S. aureus bacteremia",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32456-X/fulltext",
"pageid" : 3569,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(17)32456-X.pdf",
"trainingLevel" : "Resident",
"citation" : "Thwaites GE, et al. \"Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial\". The Lancet. 2017. 391(10121):668-678.",
"subspecialties" : "Infectious Disease",
"expansion" : "Adjunctive rifampicin for Staphylococcus Aureus Bacteraemia",
"statusUsableDate" : "2019-07-31",
"briefResultsDescription" : "Adjunctive rifampin does not reduce mortality in S. aureus bacteremia",
"published" : "2017-12-14",
"pageName" : "ARREST",
"diseases" : "Bacteremia",
"abbreviation" : "ARREST",
"title" : "Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial",
"pmid" : "29249276"
},
{
"timestamp" : "2019-10-17T17:40:06Z",
"briefDesignDescription" : "Bilateral vs. single IMA graft in multivessel CAD",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1610021",
"pageid" : 3756,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1610021",
"trainingLevel" : "Resident",
"citation" : "Taggart DP, et al. \"Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years\". The New England Journal of Medicine. 2019. 380(5):437-446.",
"subspecialties" : "Cardiology",
"expansion" : "Arterial Revascularization Trial",
"statusUsableDate" : "2019-02-02",
"briefResultsDescription" : "Single IMA grafting non-inferior to bilateral IMA grafting in multivessel CAD",
"published" : "2019-01-31",
"pageName" : "ART",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "ART",
"title" : "Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years",
"pmid" : "30699314"
},
{
"timestamp" : "2019-09-03T18:02:52Z",
"briefDesignDescription" : "Aspirin for vascular disease prevention in DM",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1804988",
"pageid" : 3698,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1804988",
"trainingLevel" : "Resident",
"citation" : "Bowman L, et al. \"Effects of aspirin for primary prevention in persons with diabetes mellitus\". The New England Journal of Medicine. 2018. epub 2018-08-26:1-11.",
"subspecialties" : "Cardiology",
"expansion" : "A Study of Cardiovascular Events in Diabetes",
"statusUsableDate" : "2018-09-06",
"briefResultsDescription" : "Aspirin reduces cardiovascular events but increases bleeding vs. placebo",
"published" : "2018-08-26",
"pageName" : "ASCEND (Aspirin)",
"diseases" : "Diabetes",
"abbreviation" : "ASCEND",
"title" : "Effects of aspirin for primary prevention in persons with diabetes mellitus",
"pmid" : "30146931"
},
{
"timestamp" : "2018-09-13T17:56:54Z",
"briefDesignDescription" : "Pirfenidone in IPF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402582",
"pageid" : 1825,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402582",
"trainingLevel" : "Fellow",
"citation" : "King TE, et al. \"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis\". The New England Journal of Medicine. 2014. 370(22):2083-2092.",
"subspecialties" : "Pulmonology",
"expansion" : "Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis",
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Pirfenidone reduces progression of IPF",
"published" : "2014-05-29",
"pageName" : "ASCEND (IPF)",
"diseases" : "Pulmonary Fibrosis",
"abbreviation" : "ASCEND",
"title" : "A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis",
"pmid" : "24836312"
},
{
"timestamp" : "2021-12-06T17:56:29Z",
"briefDesignDescription" : "Zanubrutinib vs. ibrutinib in WM",
"fulltexturl" : "https://ashpublications.org/blood/article/136/18/2038/461625/A-randomized-phase-3-trial-of-zanubrutinib-vs",
"pageid" : 4448,
"pdfurl" : "https://ashpublications.org/blood/article-pdf/136/18/2038/1779238/bloodbld2020006844.pdf",
"trainingLevel" : "Fellow",
"citation" : "Tam C, et al. \"ASPEN\". Blood. 2020. 136(18):2038-2050.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2021-11-30",
"briefResultsDescription" : "Similar efficacy, zanubrutinib perhaps less toxic",
"published" : "2020-10-29",
"pageName" : "ASPEN",
"diseases" : "Waldenström macroglobulinemia",
"abbreviation" : "ASPEN",
"title" : "ASPEN",
"pmid" : "32731259"
},
{
"timestamp" : "2017-12-03T22:33:32Z",
"briefDesignDescription" : "Aspirin after VTE treatment",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210384",
"pageid" : 1241,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210384",
"trainingLevel" : "Intern",
"citation" : "Brighton TA, et al. \"Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism\". The New England Journal of Medicine. 2012. 367(21):1979-1987.",
"subspecialties" : "Hematology",
"expansion" : "Aspirin to Prevent Recurrent Venous Thromboembolism",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "ASA probably reduces recurrent VTE",
"published" : "2012-11-04",
"pageName" : "ASPIRE",
"diseases" : "Venous Thromboembolism",
"abbreviation" : "ASPIRE",
"title" : "Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism",
"pmid" : "23121403"
},
{
"timestamp" : "2023-03-04T09:33:33Z",
"briefDesignDescription" : "Aspirin for ASCVD 1° prevention if age >70",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800722",
"pageid" : 3709,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800722",
"trainingLevel" : "Student",
"citation" : "McNeil JJ, et al. \"Effect of aspirin on disability-free survival in the healthy elderly\". The New England Journal of Medicine. 2018. 379(16):1-10.",
"subspecialties" : "Preventive Medicine;Cardiology",
"expansion" : "Aspirin in Reducing Events in the Elderly",
"statusUsableDate" : "2019-05-23",
"briefResultsDescription" : "Aspirin without 1° prevention benefit in adults >70 years",
"published" : "2018-09-16",
"pageName" : "ASPREE",
"diseases" : "Atherosclerotic Coronary Artery Disease",
"abbreviation" : "ASPREE",
"title" : "Effect of aspirin on disability-free survival in the healthy elderly",
"pmid" : "30221596"
},
{
"timestamp" : "2018-01-04T18:44:16Z",
"briefDesignDescription" : "Revascularization in RAS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0905368",
"pageid" : 1684,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0905368",
"trainingLevel" : "Resident",
"citation" : "Wheatley K, et al. \"Revascularization versus medical therapy for renal-artery stenosis\". The New England Journal of Medicine. 2009. 361(20):1953-1962.",
"subspecialties" : "Nephrology",
"expansion" : "Angioplasty and Stenting for Renal Artery Lesions",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "Revascularization no better than medical therapy alone in RAS",
"published" : "2009-11-12",
"pageName" : "ASTRAL",
"diseases" : "Renal Artery Stenosis;Hypertension",
"abbreviation" : "ASTRAL",
"title" : "Revascularization versus medical therapy for renal-artery stenosis",
"pmid" : "19907042"
},
{
"timestamp" : "2019-09-11T15:27:57Z",
"briefDesignDescription" : "Angiotensin II vs. placebo in vasodilatory shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1704154",
"pageid" : 2950,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1704154",
"trainingLevel" : "Resident",
"citation" : "Khanna A et al. \"Angiotensin II for the Treatment of Vasodilatory Shock\". New Engl J Med. 2017. 377:419-30.",
"subspecialties" : "Critical Care",
"expansion" : "Angiotensin II for the Treatment of High-Output Shock",
"statusUsableDate" : "2017-08-01",
"briefResultsDescription" : "Angiotensin II superior to placebo in vasodilatory shock",
"published" : "2017-08-03",
"pageName" : "ATHOS-3",
"diseases" : "Shock",
"abbreviation" : "ATHOS-3",
"title" : "Angiotensin II for the Treatment of Vasodilatory Shock",
"pmid" : "28528561"
},
{
"timestamp" : "2017-12-03T22:33:36Z",
"briefDesignDescription" : "10y vs. 5y tamoxifen in breast cancer",
"fulltexturl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596060/",
"pageid" : 1581,
"pdfurl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61963-1/fulltext",
"trainingLevel" : "Fellow",
"citation" : "Davies C, et al. \"Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial\". The Lancet. 2013. 381(9869):805-16.",
"subspecialties" : "Oncology",
"expansion" : "Adjuvant Tamoxifen: Longer Against Shorter",
"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "10 years of tamoxifen reduces recurrence and mortality",
"published" : "2013-03-09",
"pageName" : "ATLAS",
"diseases" : "Breast Cancer",
"abbreviation" : "ATLAS",
"title" : "Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial",
"pmid" : "23219286"
},
{
"timestamp" : "2017-12-03T22:33:37Z",
"briefDesignDescription" : "Rivaroxaban after ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112277",
"pageid" : 174,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112277",
"trainingLevel" : "Resident",
"citation" : "Mega JL, et al. \"Rivaroxaban in Patients with Recent Acute Coronary Syndrome\". The New England Journal of Medicine. 2012. 366(1):9-19.",
"subspecialties" : "Cardiology",
"expansion" : "Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51",
"statusUsableDate" : "2013-03-01",
"briefResultsDescription" : "Rivaroxaban reduces cardiovascular death, MI, and stroke, but increases nonfatal bleeding",
"published" : "2012-01-05",
"pageName" : "ATLAS ACS-2, TIMI 51",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"abbreviation" : "ATLAS ACS 2-TIMI 51",
"title" : "Rivaroxaban in Patients with Recent Acute Coronary Syndrome",
"pmid" : "22077192"
},
{
"timestamp" : "2017-12-03T22:33:39Z",
"briefDesignDescription" : "RRT intensity in ATN",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802639",
"pageid" : 2339,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802639",
"trainingLevel" : "Resident",
"citation" : "Palevsky PM, et al. \"Intensity of renal support in critically ill patients with acute kidney injury\". The New England Journal of Medicine. 2008. 359(1):7-20.",
"subspecialties" : "Nephrology;Critical Care",
"expansion" : "Acute Renal Failure Trial Network Study",
"statusUsableDate" : "2015-03-01",
"briefResultsDescription" : "Intensive RRT yields similar mortality as conventional RRT in critically ill patients with ATN",
"published" : "2008-07-03",
"pageName" : "ATN",
"diseases" : "Acute Kidney Injury;Critical Illness",
"abbreviation" : "ATN",
"title" : "Intensity of renal support in critically ill patients with acute kidney injury",
"pmid" : "18492867"
},
{
"timestamp" : "2019-05-21T14:25:21Z",
"briefDesignDescription" : "Tafamidis vs. placebo in amyloid cardiomyopathy",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1805689",
"pageid" : 3696,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1805689",
"trainingLevel" : "Resident",
"citation" : "Maurer MS, et al. \"Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy\". The New England Journal of Medicine. 2018. 379(11):1007-1016.",
"subspecialties" : "Cardiology",
"expansion" : "The Transthyretin Amyloidosis Cardiomyopathy Clinical Trial",
"statusUsableDate" : "2018-09-05",
"briefResultsDescription" : "Tafamidis superior to placebo in amyloid cardiomyopathy",
"published" : "2018-08-27",
"pageName" : "ATTR-ACT",
"diseases" : "Heart Failure",
"abbreviation" : "ATTR-ACT",
"title" : "Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy",
"pmid" : "30145929"
},
{
"timestamp" : "2019-07-17T05:12:53Z",
"briefDesignDescription" : "Pharmacomechanical therapy vs. anticoagulation in DVT",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1615066",
"pageid" : 3546,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1615066",
"trainingLevel" : "resident",
"citation" : "Vedantham S, et al. \"Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis\". The New England Journal of Medicine. 2017. 377(23):2240-2252.",
"subspecialties" : "Hematology",
"expansion" : "Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis",
"statusUsableDate" : "2018-07-19",
"briefResultsDescription" : "No difference with intervention vs. anticoagulation",
"published" : "2017-12-07",
"pageName" : "ATTRACT",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Post-Thrombotic Syndrome",
"abbreviation" : "ATTRACT",
"title" : "Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis",
"pmid" : "29211671"
},
{
"timestamp" : "2023-02-07T21:36:04Z",
"briefDesignDescription" : "DOAC, VKA, antiplatelets after PCI with stent and AF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1817083",
"pageid" : 3947,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817083",
"trainingLevel" : "Resident",
"citation" : "Lopes RD, et al. \"Antithrombotic therapy after acute coronary syndrome or PCI in atrial fibrillation\". The New England Journal of Medicine. 2019. 380(16):1509-1524.",
"subspecialties" : "Cardiology",
"expansion" : "An Open-label, 2 x 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban vs. Vitamin K Antagonist and Aspirin vs. Aspirin Placebo in Patients with Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention",
"statusUsableDate" : "2019-10-17",
"briefResultsDescription" : "Apixaban with lower bleeding",
"published" : "2019-04-18",
"pageName" : "AUGUSTUS",
"diseases" : "Coronary artery disease;Atrial Fibrillation",
"abbreviation" : "AUGUSTUS",
"title" : "Antithrombotic therapy after acute coronary syndrome or PCI in atrial fibrillation",
"pmid" : "30883055"
},
{
"timestamp" : "2018-12-20T20:31:01Z",
"briefDesignDescription" : "Rosuvastatin in ESRD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810177",
"pageid" : 2390,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810177",
"trainingLevel" : "Resident",
"citation" : "Fellstrom BC, et al. \"Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis\". The New England Journal of Medicine. 2009. 360(14):1395-1407.",
"subspecialties" : "Cardiology;Nephrology",
"expansion" : "A Study to Evaluate the Use of Rosuvastatin in Subjects on Regular Hemodialysis: An Assessment of Survival and Cardiovascular Events",
"statusUsableDate" : "2018-12-20",
"briefResultsDescription" : "No difference in number of cardiovascular events",
"published" : "2009-04-02",
"pageName" : "AURORA",
"diseases" : "Cardiovascular Disease;Myocardial Infarction;Stroke",
"abbreviation" : "AURORA",
"title" : "Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis",
"pmid" : "19332456"
},
{
"timestamp" : "2017-12-03T22:33:40Z",
"briefDesignDescription" : "Apixaban vs. ASA in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007432",
"pageid" : 1718,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007432",
"trainingLevel" : "Intern",
"citation" : "Connolly SJ, et al. \"Apixaban in patients with atrial fibrillation\". The New England Journal of Medicine. 2011. 364(9):806-817.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment",
"statusUsableDate" : "2013-11-01",
"briefResultsDescription" : "Apixaban better than ASA without increased bleeding in AF",
"published" : "2011-03-03",
"pageName" : "AVERROES",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"abbreviation" : "AVERROES",
"title" : "Apixaban in patients with atrial fibrillation",
"pmid" : "21309657"
},
{
"timestamp" : "2019-02-05T14:44:30Z",
"briefDesignDescription" : "Apixaban for VTE prevention in cancer",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1814468",
"pageid" : 3752,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1814468",
"trainingLevel" : "Resident",
"citation" : "Carrier M, et al. \"Apixaban to Prevent Venous Thromboembolism in Patients with Cancer\". The New England Journal of Medicine. 2018. E-pub 2018-12-04:1-8.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "Apixaban for the Prevention of Venous Thromboembolism in High-Risk Ambulatory Cancer Patients",
"statusUsableDate" : "2019-01-31",
"briefResultsDescription" : "Apixaban reduces risk of VTE, increases risk of bleeding",
"published" : "2018-12-04",
"pageName" : "AVERT",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "AVERT",
"title" : "Apixaban to Prevent Venous Thromboembolism in Patients with Cancer",
"pmid" : "30511879"
},
{
"timestamp" : "2017-12-03T22:33:41Z",
"briefDesignDescription" : "Supplemental oxygen in STEMI",
"fulltexturl" : "http://circ.ahajournals.org/content/131/24/2143",
"pageid" : 2930,
"pdfurl" : "http://circ.ahajournals.org/content/131/24/2143.full.pdf",
"trainingLevel" : "Intern",
"citation" : "Stub D, et al. \"Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction\". Circulation. 2015. 131(24):2143-2150.",
"subspecialties" : "Cardiology",
"expansion" : "Comparing Oxygen with normal air in patients with ST-Segment Elevation Myocardial Infarction who are not hypoxic.",
"statusUsableDate" : "2017-09-01",
"briefResultsDescription" : "No benefit from in non-hypoxemic patients with STEMI",
"published" : "2015-05-22",
"pageName" : "AVOID",
"diseases" : "Myocardial Infarction",
"abbreviation" : "AVOID",
"title" : "Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction",
"pmid" : "26002889"
},
{
"timestamp" : "2017-12-03T22:33:42Z",
"briefDesignDescription" : "Zidovudine in HIV/AIDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198707233170401",
"pageid" : 1775,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198707233170401",
"trainingLevel" : "Student",
"citation" : "Fischl MA et al. \"The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex\". The New England Journal of Medicine. 1987. 317(4):185-191.",
"subspecialties" : "Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2014-01-01",
"briefResultsDescription" : "Zidovudine reduces mortality in HIV/AIDS",
"published" : "1987-07-23",
"pageName" : "AZT Trial",
"diseases" : "HIV",
"abbreviation" : "",
"title" : "The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex",
"pmid" : "3299089"
},
{
"timestamp" : "2020-08-20T18:18:36Z",
"briefDesignDescription" : "Beta-blocker withdrawal in ADHF",
"fulltexturl" : "https://doi.org/10.1093/eurheartj/ehp323",
"pageid" : 4250,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "Jondeau G, et al. \"B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode\". Eur Heart J. 2009. 30(18):2186-2192.",
"subspecialties" : "Cardiology",
"expansion" : "Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode",
"statusUsableDate" : "2020-08-20",
"briefResultsDescription" : "Beta-blocker withdrawal not needed in ADHF",
"published" : "2009-08-30",
"pageName" : "B-CONVINCED",
"diseases" : "Heart Failure",
"abbreviation" : "B-CONVINCED",
"title" : "B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode",
"pmid" : "19717851"
},
{
"timestamp" : "2017-12-03T22:33:47Z",
"briefDesignDescription" : "CABG/PCI vs. OMT in diabetes with CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805796",
"pageid" : 1471,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805796",
"trainingLevel" : "Resident",
"citation" : "Frye RL, et al. \"A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease\". The New England Journal of Medicine. 2009. 360(24):2503-2515.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "Bypass Angioplasty Revascularization Investigation 2 Diabetes",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "CABG is superior to OMT in diabetics with CAD",
"published" : "2009-06-11",
"pageName" : "BARI 2D",
"diseases" : "Coronary Artery Disease;Diabetes Mellitus",
"abbreviation" : "BARI 2D",
"title" : "A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease",
"pmid" : "19502645"
},
{
"timestamp" : "2017-12-03T22:33:48Z",
"briefDesignDescription" : "Symptom-based asthma therapy",
"fulltexturl" : "http://bit.ly/1FNk0v0",
"pageid" : 1864,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/24854/joc120069_987_997.pdf",
"trainingLevel" : "Resident",
"citation" : "Calhoun WJ, et al. \"Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial\". Journal of the American Medical Association. 2012. 308(10):987-997.",
"subspecialties" : "Pulmonology",
"expansion" : "Best Adjustment Strategy for Asthma in the Long Term",
"statusUsableDate" : "2015-03-01",
"briefResultsDescription" : "Symptom-, biomarker-, and physician-based treatments are similar",
"published" : "2012-09-12",
"pageName" : "BASALT",
"diseases" : "Asthma",
"abbreviation" : "BASALT",
"title" : "Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial",
"pmid" : "22968888"
},
{
"timestamp" : "2023-12-15T03:08:03Z",
"briefDesignDescription" : "Tisa-cel vs. ASCT in R/R DLBCL",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2116596",
"pageid" : 4462,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2116596",
"trainingLevel" : "Fellow",
"citation" : "Bishop MR, et al. \"Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma\". The New England Journal of Medicine. 2022. 368(7):629-639.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2023-12-14",
"briefResultsDescription" : "CART did not improve PFS compared to ASCT",
"published" : "2022-02-17",
"pageName" : "BELINDA",
"diseases" : "Lymphoma;Aggressive B-cell lymphoma",
"abbreviation" : "BELINDA",
"title" : "Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma",
"pmid" : "34904798"
},
{
"timestamp" : "2017-12-03T22:33:54Z",
"briefDesignDescription" : "Benazepril in non-diabetic CKD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa053107",
"pageid" : 2674,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa053107",
"trainingLevel" : "Resident",
"citation" : "Hou FF, et al. \"Effect and Safety of Benazepril for Advanced Chronic Renal Insufficiency\". The New England Journal of Medicine. 2006. 354(2):131-140.",
"subspecialties" : "Nephrology",
"expansion" : "",
"statusUsableDate" : "2016-02-01",
"briefResultsDescription" : "Benazepril improves renal outcomes in non-diabetic CKD",
"published" : "2006-01-12",
"pageName" : "Benazepril in Severe CKD",
"diseases" : "Chronic Kidney Disease",
"abbreviation" : "",
"title" : "Effect and Safety of Benazepril for Advanced Chronic Renal Insufficiency",
"pmid" : "16407508"
},
{
"timestamp" : "2022-04-17T20:47:43Z",
"briefDesignDescription" : "DMARD ± prednisone or infliximab in RA",
"fulltexturl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/abstract",
"pageid" : 77,
"pdfurl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/pdf",
"trainingLevel" : "Resident",
"citation" : "Goekoop-Ruiterman YP, et al. \"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis\". Arthritis & Rheumatism. 2005. 52(11):3381-3390.",
"subspecialties" : "Rheumatology",
"expansion" : "Behandel-Strategeieën (\"treatment strategies\" in Dutch)",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Combination therapy produces early functional improvement than DMARD alone",
"published" : "2005-11-01",
"pageName" : "BeSt",
"diseases" : "Rheumatoid Arthritis",
"abbreviation" : "BeSt",
"title" : "Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis",
"pmid" : "16258899"
},
{
"timestamp" : "2017-12-03T22:33:49Z",
"briefDesignDescription" : "PCI vs. CABG for multivessel disease",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1415447",
"pageid" : 2916,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1415447",
"trainingLevel" : "Resident",
"citation" : "Reardon MJ, et al. \"Trial of everolimus-eluting stents or bypass surgery for coronary disease\". The New England Journal of Medicine. 2015. 372(13):1204-12.",
"subspecialties" : "Cardiology",
"expansion" : "The Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation",
"statusUsableDate" : "2017-05-01",
"briefResultsDescription" : "PCI inferior to CABG for multivessel disease",
"published" : "2015-03-26",
"pageName" : "BEST",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "BEST",
"title" : "Trial of everolimus-eluting stents or bypass surgery for coronary disease",
"pmid" : "25774645"
},
{
"timestamp" : "2019-03-05T05:23:16Z",
"briefDesignDescription" : "Bicarbonate in severe metabolic acidosis",
"fulltexturl" : "https://doi.org/10.1016/S0140-6736(18)31080-8",
"pageid" : 3721,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Jaber S, et al. \"Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial\". The Lancet. 2018. 392(10141):31-40.",
"subspecialties" : "Critical Care",
"expansion" : "Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill: A Multiple Center Randomized Clinical Trial",
"statusUsableDate" : "2019-02-28",
"briefResultsDescription" : "No improvement in death with sodium bicarb in ICU patients",
"published" : "2018-07-07",
"pageName" : "BICAR-ICU",
"diseases" : "Metabolic Acidosis;Critical Illness",
"abbreviation" : "BICAR-ICU",
"title" : "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial",
"pmid" : "29910040"
},
{
"timestamp" : "2019-03-26T21:31:31Z",
"briefDesignDescription" : "RV pacing vs. BiV pacing in HF with AV block",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210356",
"pageid" : 2422,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210356",
"trainingLevel" : "resident",
"citation" : "Curtis A.B., et al. \"Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block\". The New England Journal of Medicine. 2013. 368(17):1585-1593.",
"subspecialties" : "Cardiology",
"expansion" : "Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block",
"statusUsableDate" : "2017-06-01",
"briefResultsDescription" : "Biventricular pacing superior to right ventricular pacing in patients with CHF with AV block",
"published" : "2013-04-25",
"pageName" : "BLOCK-HF",
"diseases" : "Atrioventricular Block",
"abbreviation" : "BLOCK-HF",
"title" : "Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block",
"pmid" : "23614585"
},
{
"timestamp" : "2018-07-04T03:11:36Z",
"briefDesignDescription" : "PharmD-guided BP reduction for black men in barbershops",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1717250",
"pageid" : 3578,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1717250",
"trainingLevel" : "Resident",
"citation" : "Victor RG, et al. \"A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops\". The New England Journal of Medicine. 2018. 378(14):1291-1301.",
"subspecialties" : "Cardiology",
"expansion" : "Blood-Pressure Reduction in Black Barbershops",
"statusUsableDate" : "2018-04-05",
"briefResultsDescription" : "Pharmacist intervention with health promotion superior to health promotion alone",
"published" : "2018-04-05",
"pageName" : "Blood Pressure Reduction in Black Barbershops",
"diseases" : "Hypertension",
"abbreviation" : "Blood-Pressure Reduction in Black Barbershops",
"title" : "A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops",
"pmid" : "29527973"
},
{
"timestamp" : "2018-01-17T21:45:20Z",
"briefDesignDescription" : "LMWH bridging for surgery in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501035",
"pageid" : 2402,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501035",
"trainingLevel" : "Intern",
"citation" : "Douketis JD, et al. \"Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2015. 373(9):823-33.",
"subspecialties" : "Cardiology;Hematology",
"expansion" : "Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for Elective Invasive Procedure or Surgery",
"statusUsableDate" : "2015-07-01",
"briefResultsDescription" : "LMWH bridging didn't reduce VTE but increased bleeding",
"published" : "2015-06-22",
"pageName" : "BRIDGE",
"diseases" : "Atrial Fibrillation;Stroke",
"abbreviation" : "BRIDGE",
"title" : "Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation",
"pmid" : "26095867"
},
{
"timestamp" : "2017-12-03T22:33:53Z",
"briefDesignDescription" : "Vemurafenib in BRAF V600+ melanoma",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1103782",
"pageid" : 2391,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1103782",
"trainingLevel" : "Fellow",
"citation" : "Chapman BP, et al. \"Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation\". The New England Journal of Medicine. 2011. 364(26):2507-2516.",
"subspecialties" : "Oncology",
"expansion" : "BRAF Inhibitor in Melanoma 3",
"statusUsableDate" : "2015-07-01",
"briefResultsDescription" : "Vemurafenib improves survival in BRAF V600-mutated melanoma",
"published" : "2011-06-30",
"pageName" : "BRIM-3",
"diseases" : "Melanoma",
"abbreviation" : "BRIM-3",
"title" : "Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation",
"pmid" : "21639808"
},
{
"timestamp" : "2019-04-11T17:25:17Z",
"briefDesignDescription" : "Catheter ablation vs. anti-arrhythmic therapy in AF",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2728676",
"pageid" : 3950,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Packer DL, et al. \"Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation\". JAMA. 2019. 321(13):1261-1274.",
"subspecialties" : "Cardiology",
"expansion" : "Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation",
"statusUsableDate" : "2019-04-11",
"briefResultsDescription" : "Catheter ablation does not reduce cardiovascular events in patients with AF",
"published" : "2019-04-11",
"pageName" : "CABANA",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "CABANA",
"title" : "Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation",
"pmid" : "30874766"
},
{
"timestamp" : "2017-12-04T00:13:32Z",
"briefDesignDescription" : "Methotrexate strategies in RA",
"fulltexturl" : "http://ard.bmj.com/content/66/11/1443.long",
"pageid" : 2859,
"pdfurl" : "http://ard.bmj.com/content/66/11/1443.full.pdf",
"trainingLevel" : "Fellow",
"citation" : "Verstappen SM, et al. \"Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)\". Annals of the Rheumatic Diseases. 2007. 66(11):1443-1449.",
"subspecialties" : "Rheumatology",
"expansion" : "Computer Assisted Management in Early Rheumatoid Arthritis",
"statusUsableDate" : "2017-11-30",
"briefResultsDescription" : "Intensive methotrexate dosing better than conventional",
"published" : "2007-11-01",
"pageName" : "CAMERA",
"diseases" : "Rheumatoid Arthritis",
"abbreviation" : "CAMERA",
"title" : "Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)",
"pmid" : "17519278"
},
{
"timestamp" : "2017-12-03T22:34:40Z",
"briefDesignDescription" : "Light therapy vs. SSRI for SAD",
"fulltexturl" : "http://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2006.163.5.805",
"pageid" : 2173,
"pdfurl" : "http://ajp.psychiatryonline.org/doi/pdf/10.1176/ajp.2006.163.5.805",
"trainingLevel" : "Intern",
"citation" : "Lam RW, et al. \"The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder\". The American Journal of Psychiatry. 2006. 165(5):805-812.",
"subspecialties" : "Psychiatry",
"expansion" : null,
"statusUsableDate" : "2015-04-01",
"briefResultsDescription" : "No difference between light therapy and SSRI in SAD",
"published" : "2006-05-01",
"pageName" : "Can-SAD",
"diseases" : "Seasonal Affective Disorder;Depression",
"abbreviation" : "Can-SAD",
"title" : "The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder",
"pmid" : "16648320"
},
{
"timestamp" : "2012-06-13T05:04:26Z",
"briefDesignDescription" : "CT head rules for trauma",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)04561-X/fulltext",
"pageid" : 93,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS014067360004561X.pdf",
"trainingLevel" : "resident",
"citation" : "Stiell IG, et al. \"The Canadian CT Head Rule for patients with minor head trauma\". The Lancet. 2001. 357(9266):1391-96.",
"subspecialties" : "Emergency Medicine;Neurology",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "GCS score, skull fracture, emesis, age, amnesia, and mechanism predict risk",
"published" : "2001-05-05",
"pageName" : "Canadian CT Head Rule",
"diseases" : "Trauma",
"abbreviation" : "",
"title" : "The Canadian CT Head Rule for patients with minor head trauma",
"pmid" : "11356436"
},
{
"timestamp" : "2018-11-12T16:15:18Z",
"briefDesignDescription" : "Canakinumab in patients with previous MI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1707914",
"pageid" : 2964,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1707914",
"trainingLevel" : "Resident",
"citation" : "Ridker PM, et al. \"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease\". The New England Journal of Medicine. 2017. 377(12):1119-1131.",
"subspecialties" : "Cardiology",
"expansion" : "Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)",
"statusUsableDate" : "2017-10-01",
"briefResultsDescription" : "Canakinumab reduces cardiovascular events in patients with previous MI",
"published" : "2017-08-27",
"pageName" : "CANTOS",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "CANTOS",
"title" : "Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease",
"pmid" : "28845751"
},
{
"timestamp" : "2022-10-13T17:45:18Z",
"briefDesignDescription" : "Canagliflozin for CV outcomes in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611925",
"pageid" : 2952,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611925",
"trainingLevel" : "intern",
"citation" : "Neal B, et al. \"Canagliflozin and cardiovascular and renal events in type 2 diabetes\". The New England Journal of Medicine. 2017. 377(7):644-657.",
"subspecialties" : "Endocrinology;Cardiology;Nephrology",
"expansion" : "Canagliflozin Cardiovascular Assessment Study",
"statusUsableDate" : "2017-08-01",
"briefResultsDescription" : "Canagliflozin reduces CV events compared to placebo in patients with type 2 diabetes",
"published" : "2017-08-17",
"pageName" : "CANVAS",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "CANVAS",
"title" : "Canagliflozin and cardiovascular and renal events in type 2 diabetes",
"pmid" : "28605608"
},
{
"timestamp" : "2018-03-08T18:31:23Z",
"briefDesignDescription" : "Antibiotic strategies for PNA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1406330",
"pageid" : 2838,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1406330",
"trainingLevel" : "Student",
"citation" : "Postma DF, et al. \"Antibiotic treatment strategies for community-acquired pneumonia in adults\". The New England Journal of Medicine. 2015. 372(14):1312-1323.",
"subspecialties" : "Infectious Disease",
"expansion" : "Community-Acquired Pneumonia—Study on the Initial Treatment with Antibiotics of Lower Respiratory Tract Infections",
"statusUsableDate" : "2018-03-08",
"briefResultsDescription" : "Beta-lactam alone is noninferior to quinolone or beta-lactam+macrolide",
"published" : "2015-04-02",
"pageName" : "CAP-START",
"diseases" : "Pneumonia",
"abbreviation" : "CAP-START",
"title" : "Antibiotic treatment strategies for community-acquired pneumonia in adults",
"pmid" : "25830421"
},
{
"timestamp" : "2023-04-24T20:34:11Z",
"briefDesignDescription" : "Hydrocortisone in severe CAP",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2215145",
"pageid" : 5318,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2215145",
"trainingLevel" : "student",
"citation" : "Dequin PF, et al. \"Hydrocortisone in severe community-acquired pneumonia\". The New England Journal of Medicine. 2023. Epub 2023-03-21:1-11.",
"subspecialties" : "Critical Care;Pulmonology",
"expansion" : "",
"statusUsableDate" : "2023-04-06",
"briefResultsDescription" : "Hydrocortisone lowers mortality in severe CAP",
"published" : "2023-03-21",
"pageName" : "CAPE COD",
"diseases" : "Pneumonia",
"abbreviation" : "CAPE COD",
"title" : "Hydrocortisone in severe community-acquired pneumonia",
"pmid" : "36942789"
},
{
"timestamp" : "2019-03-15T15:10:50Z",
"briefDesignDescription" : "Carvedilol post-MI with HFrEF",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)04560-8",
"pageid" : 2944,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(00)04560-8.pdf",
"trainingLevel" : "resident",
"citation" : "Dargie HJ, et al. \"Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial\". The Lancet. 2001. 357(9266):1385-1390.",
"subspecialties" : "Cardiology",
"expansion" : "Carvedilol Post-Infarct Survival Control in LV Dysfunction",
"statusUsableDate" : "2019-03-07",
"briefResultsDescription" : "Improved mortality with carvedilol post-MI with LVEF ≤40%",
"published" : "2001-05-01",
"pageName" : "CAPRICORN",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "CAPRICORN",
"title" : "Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial",
"pmid" : "11356434"
},
{
"timestamp" : "2023-03-30T18:14:36Z",
"briefDesignDescription" : "Clopidogrel vs. aspirin in CV disease",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(96)09457-3/fulltext",
"pageid" : 7,
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"trainingLevel" : "Intern",
"citation" : "Gent M, et al. \"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events\". The Lancet. 1996. 348(9038):1329-39.",
"subspecialties" : "Neurology;Cardiology",
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"pageName" : "CAPRIE",
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"title" : "A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events",
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{
"timestamp" : "2020-11-05T18:09:03Z",
"briefDesignDescription" : "Apixaban vs. dalteparin in cancer VTE",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1915103",
"pageid" : 4265,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915103",
"trainingLevel" : "resident",
"citation" : "Agnelli G, et al. \"Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer\". The New England Journal of Medicine. 2020. 382:1599-607.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2020-10-31",
"briefResultsDescription" : "Apixaban is noninferior to dalteparin for cancer VTE",
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"pageName" : "CARAVAGGIO",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
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"title" : "Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer",
"pmid" : "32223112"
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"timestamp" : "2017-12-03T22:33:59Z",
"briefDesignDescription" : "Preop coronary revascularization if stable CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041905",
"pageid" : 1332,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041905",
"trainingLevel" : "Resident",
"citation" : "McFalls EO, et al. \"Coronary-artery revascularization before elective major vascular surgery\". The New England Journal of Medicine. 2004. 351(27):2795-2804.",
"subspecialties" : "Cardiology;Preventive Medicine",
"expansion" : "",
"statusUsableDate" : "2015-09-01",
"briefResultsDescription" : "Preop coronary revascularization doesn't reduce mortality",
"published" : "2004-12-30",
"pageName" : "CARP",
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"abbreviation" : "CARP",
"title" : "Coronary-artery revascularization before elective major vascular surgery",
"pmid" : "15625331"
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{
"timestamp" : "2017-12-03T22:34:00Z",
"briefDesignDescription" : "Ultrafiltration in decompensated HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210357",
"pageid" : 1356,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210357",
"trainingLevel" : "Resident",
"citation" : "Bart BA, et al. \"Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome\". The New England Journal of Medicine. 2012. 367(24):2296-2304.",
"subspecialties" : "Cardiology",
"expansion" : "Cardiorenal Rescue Study in Acute Decompensated Heart Failure",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "Ultrafiltration worse then meds in acute HF",
"published" : "2012-12-13",
"pageName" : "CARRESS-HF",
"diseases" : "Heart Failure",
"abbreviation" : "CARRESS-HF",
"title" : "Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome",
"pmid" : "23131078"
},
{
"timestamp" : "2019-05-23T17:55:30Z",
"briefDesignDescription" : "Rivaroxaban for VTE prevention in cancer",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1814630",
"pageid" : 3945,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1814630",
"trainingLevel" : "Resident",
"citation" : "Khorana AA, et al. \"Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer\". The New England Journal of Medicine. 2019. 380(8):720-8.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer",
"statusUsableDate" : "2019-03-07",
"briefResultsDescription" : "Rivaroxaban did not reduce VTE",
"published" : "2019-02-21",
"pageName" : "CASSINI",
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"title" : "Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer",
"pmid" : "30786186"
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{
"timestamp" : "2017-12-03T22:34:01Z",
"briefDesignDescription" : "Antiarrhythmics post-MI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199103213241201",
"pageid" : 1110,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199103213241201",
"trainingLevel" : "Resident",
"citation" : "Echt DS, et al. \"Mortality and morbidity in patients receiving encainide, flecainide, or placebo\". The New England Journal of Medicine. 1991. 324(12):781-788.",
"subspecialties" : "Cardiology",
"expansion" : "Cardiac Arrhythmia Suppression Trial",
"statusUsableDate" : "2012-12-01",
"briefResultsDescription" : "Antiarrhythmics increase mortality",
"published" : "1991-03-21",
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"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "CAST I",
"title" : "Mortality and morbidity in patients receiving encainide, flecainide, or placebo",
"pmid" : "1900101"
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{
"timestamp" : "2018-08-10T15:33:15Z",
"briefDesignDescription" : "Catheter ablation vs. standard therapy in AF+HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1707855",
"pageid" : 3533,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1707855",
"trainingLevel" : "Resident",
"citation" : "Marrouche NF, et al. \"Catheter Ablation for Atrial Fibrillation with Heart Failure\". The New England Journal of Medicine. 2018. 378(5):417-27.",
"subspecialties" : "Cardiology",
"expansion" : "Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation",
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"published" : "2018-02-01",
"pageName" : "CASTLE-AF",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "CASTLE-AF",
"title" : "Catheter Ablation for Atrial Fibrillation with Heart Failure",
"pmid" : "29385358"
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{
"timestamp" : "2017-12-03T22:34:03Z",
"briefDesignDescription" : "Antipsychotics in schizophrenia",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa051688",
"pageid" : 419,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa051688",
"trainingLevel" : "Resident",
"citation" : "Lieberman JA, et al. \"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia\". The New England Journal of Medicine. 2005. 353(12):1209-23.",
"subspecialties" : "Psychiatry",
"expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness",
"statusUsableDate" : "2012-06-01",
"briefResultsDescription" : "Olanzapine ↓discontinuations but ↑metabolic syndrome, and perphenazine ˜ atypicals",
"published" : "2005-09-22",
"pageName" : "CATIE",
"diseases" : "Schizophrenia",
"abbreviation" : "CATIE",
"title" : "Effectiveness of antipsychotic drugs in patients with chronic schizophrenia",
"pmid" : "16172203"
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{
"timestamp" : "2017-12-03T22:34:04Z",
"briefDesignDescription" : "Antipsychotics in dementia with psychosis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061240",
"pageid" : 2724,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061240",
"trainingLevel" : "Intern",
"citation" : "Schneider LS, et al. \"Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease\". The New England Journal of Medicine. 2006. 355(15):1525-38.",
"subspecialties" : "Psychiatry",
"expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness–Alzheimer's Disease",
"statusUsableDate" : "2016-04-01",
"briefResultsDescription" : "Antipsychotics no better than placebo",
"published" : "2006-10-12",
"pageName" : "CATIE-AD",
"diseases" : "Dementia;Alzheimer Disease;Psychosis",
"abbreviation" : "CATIE-AD",
"title" : "Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease",
"pmid" : "17035647"
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{
"timestamp" : "2017-12-03T22:34:05Z",
"briefDesignDescription" : "Ranibizumab vs. bevacizumab for macular degeneration",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102673",
"pageid" : 2250,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102673",
"trainingLevel" : "Resident",
"citation" : "The CATT Research Group Writers. \"Ranibizumab and bevacizumab for neovascular age-related macular degeneration\". The New England Journal of Medicine. 2011. 364(20):1897-1908.",
"subspecialties" : "Ophthalmology",
"expansion" : "Comparison of Age-Related Macular Degeneration Treatment Trails",
"statusUsableDate" : "2014-10-01",
"briefResultsDescription" : "Ranibizumab vs. bevacizumab similar even when comparing monthly vs. PRN scheduling",
"published" : "2011-05-19",
"pageName" : "CATT",
"diseases" : "Macular Degeneration",
"abbreviation" : "CATT",
"title" : "Ranibizumab and bevacizumab for neovascular age-related macular degeneration",
"pmid" : "21526923"
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{
"timestamp" : "2019-03-07T17:23:15Z",
"briefDesignDescription" : "Cangrelor during urgent or elective PCI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300815",
"pageid" : 2935,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300815",
"trainingLevel" : "Fellow",
"citation" : "Bhatt DL, et al. \"Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events\". The New England Journal of Medicine. 2013. 368(14):1303-1313.",
"subspecialties" : "Cardiology",
"expansion" : "Cangrelor versus standard therapy to achieve optimal management of platelet inhibition",
"statusUsableDate" : "2017-06-01",
"briefResultsDescription" : "Cangrelor reduces rate of ischemic events during PCI",
"published" : "2013-04-04",
"pageName" : "CHAMPION PHOENIX",
"diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "CHAMPION PHOENIX",
"title" : "Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events",
"pmid" : "23473369"
},
{
"timestamp" : "2020-01-03T00:19:05Z",
"briefDesignDescription" : "ASA/clopidogrel vs. ASA in TIA/stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1215340",
"pageid" : 1530,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1215340",
"trainingLevel" : "Resident",
"citation" : "Wang Y, et al. \"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack\". The New England Journal of Medicine. 2013. 369(1):11-19.",
"subspecialties" : "Neurology",
"expansion" : "Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "ASA/clopidogrel decreases stroke rates compared to ASA alone in TIA and high-risk CVA",
"published" : "2013-07-04",
"pageName" : "CHANCE",
"diseases" : "Stroke;Transient Ischemic Attack",
"abbreviation" : "CHANCE",
"title" : "Clopidogrel with aspirin in acute minor stroke or transient ischemic attack",
"pmid" : "23803136"
},
{
"timestamp" : "2018-03-08T18:57:50Z",
"briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin for CV prevention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa060989",
"pageid" : 2175,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa060989",
"trainingLevel" : "Resident",
"citation" : "Bhatt DL, et al. \"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events\". The New England Journal of Medicine. 2006. 354(16):1706-1717.",
"subspecialties" : "Cardiology",
"expansion" : "Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance",
"statusUsableDate" : "2014-10-01",
"briefResultsDescription" : "Combination therapy no better than aspirin alone, more bleeding",
"published" : "2006-04-20",
"pageName" : "CHARISMA",
"diseases" : "Cardiovascular Disease;Stroke;Myocardial Infarction;Acute Coronary Syndrome",
"abbreviation" : "CHARISMA",
"title" : "Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events",
"pmid" : "16531616"
},
{
"timestamp" : "2017-12-03T22:34:11Z",
"briefDesignDescription" : "ARB plus ACE-I in HF",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2914283-3/fulltext",
"pageid" : 2126,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603142833.pdf",
"trainingLevel" : "Intern",
"citation" : "McMurray JJ, et al. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial\". The Lancet. 2003. 362(9386):767-771.",
"subspecialties" : "Cardiology",
"expansion" : null,
"statusUsableDate" : "2014-08-01",
"briefResultsDescription" : "Adding ARB to ACE-I reduces CV events and HF hospitalizations",
"published" : "2003-09-06",
"pageName" : "CHARM-Added",
"diseases" : "Heart Failure",
"abbreviation" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Added",
"title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial",
"pmid" : "13678869"
},
{
"timestamp" : "2023-03-30T17:58:17Z",
"briefDesignDescription" : "ARBs in HFrEF",
"fulltexturl" : "https://doi.org/10.1016/s0140-6736(03)14284-5",
"pageid" : 2416,
"pdfurl" : "",
"trainingLevel" : "Intern",
"citation" : "Granger CB, et al. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial\". The Lancet. 2003. 362(9386):772-776.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2023-03-29",
"briefResultsDescription" : "ARBs reduce CV mortality and HF hospitalization in HFrEF",
"published" : "2003-09-06",
"pageName" : "CHARM-Alternative",
"diseases" : "Heart Failure",
"abbreviation" : "CHARM-Alternative",
"title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial",
"pmid" : "13678870"
},
{
"timestamp" : "2017-12-03T22:34:16Z",
"briefDesignDescription" : "ARBs in HFpEF",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14285-7/fulltext",
"pageid" : 2381,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14285-7.pdf",
"trainingLevel" : "Intern",
"citation" : "Yusuf S, et al. \"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial\". The Lancet. 2003. 362(9386):777-781.",
"subspecialties" : "Cardiology",
"expansion" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved",
"statusUsableDate" : "2015-06-01",
"briefResultsDescription" : "Candesartan modestly reduces HF admissions but does not affect CV mortality",
"published" : "2003-09-06",
"pageName" : "CHARM-Preserved",
"diseases" : "Heart Failure",
"abbreviation" : "CHARM-Preserved",
"title" : "Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial",
"pmid" : "13678871"
},
{
"timestamp" : "2017-12-03T22:34:42Z",
"briefDesignDescription" : "Nivolumab in solid tumors",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200690",
"pageid" : 2220,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200690",
"trainingLevel" : "Resident",
"citation" : "Topalian SL, et al. \"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer\". The New England Journal of Medicine. 2012. 366(26):2443-54.",
"subspecialties" : "Oncology",
"expansion" : "",
"statusUsableDate" : "2014-10-01",
"briefResultsDescription" : "Nivolumab was well tolerated, yielded durable remissions in about 30% of patients",
"published" : "2012-06-28",
"pageName" : "CheckMate-003",
"diseases" : "Melanoma;Lung Cancer;Renal Cell Carcinoma",
"abbreviation" : "",
"title" : "Safety, activity, and immune correlates of anti-PD-1 antibody in cancer",
"pmid" : "22658127"
},
{
"timestamp" : "2017-12-03T22:34:18Z",
"briefDesignDescription" : "Free long-acting reversible contraception in teens",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1400506",
"pageid" : 2233,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1400506",
"trainingLevel" : "Student",
"citation" : "Secura GM, et al. \"Provision of no-cost, long-acting contraception and teenage pregnancy\". The New England Journal of Medicine. 2014. 371(14):1316-1326.",
"subspecialties" : "Gynecology;Preventive Medicine;Obstetrics",
"expansion" : "CHOICE is not an abbreviation per a communication with the research team",
"statusUsableDate" : "2014-10-01",
"briefResultsDescription" : "LARC reduced pregnancy, live births, and abortions",
"published" : "2014-10-02",
"pageName" : "CHOICE",
"diseases" : "Unplanned Pregnancy",
"abbreviation" : "CHOICE",
"title" : "Provision of no-cost, long-acting contraception and teenage pregnancy",
"pmid" : "25271604"
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{
"timestamp" : "2019-02-21T16:44:19Z",
"briefDesignDescription" : "EPO in CKD with anemia",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa065485",
"pageid" : 422,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa065485",
"trainingLevel" : "Resident",
"citation" : "Singh AK, et al. \"Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease\". The New England Journal of Medicine. 2006. 355(20):2085-2098.",
"subspecialties" : "Nephrology;Hematology",
"expansion" : "Correction of Hemoglobin and Outcomes in Renal Insufficiency",
"statusUsableDate" : "2012-05-01",
"briefResultsDescription" : "Increased morbidity/mortality with higher hgb targets",
"published" : "2006-11-16",
"pageName" : "CHOIR",
"diseases" : "Chronic Kidney Disease;Anemia",
"abbreviation" : "CHOIR",
"title" : "Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease",
"pmid" : "17108343"
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{
"timestamp" : "2023-02-02T19:39:17Z",
"briefDesignDescription" : "Bisoprolol in HFrEF",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140673698111819",
"pageid" : 2436,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "CIBIS-II Writers. \"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial\". The Lancet. 1999. 353(9146):9-13.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2023-01-30",
"briefResultsDescription" : "Bisoprolol lowers mortality in HFrEF",
"published" : "1999-01-02",
"pageName" : "CIBIS-II",
"diseases" : "Heart Failure",
"abbreviation" : "CIBIS-II",
"title" : "The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial",
"pmid" : "10023943"
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{
"timestamp" : "2018-11-30T20:42:52Z",
"briefDesignDescription" : "Low-dose MTX for secondary prevention of CAD",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1809798",
"pageid" : 3739,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1809798",
"trainingLevel" : "Resident",
"citation" : "Ridker PM, et al. \"Low-dose methotrexate for the prevention of atherosclerotic events\". The New England Journal of Medicine. 2018. epub 2018-11-10:1-11.",
"subspecialties" : "Cardiology",
"expansion" : "Cardiovascular Inflammation Reduction Trial",
"statusUsableDate" : "2018-11-14",
"briefResultsDescription" : "Low-dose methotrexate not superior to placebo for secondary prevention of CAD",
"published" : "2018-11-10",
"pageName" : "CIRT",
"diseases" : "Coronary artery disease",
"abbreviation" : "CIRT",
"title" : "Low-dose methotrexate for the prevention of atherosclerotic events",
"pmid" : "30415610"
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{
"timestamp" : "2017-12-03T22:34:21Z",
"briefDesignDescription" : "PFO closure in cryptogenic stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009639",
"pageid" : 1093,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009639",
"trainingLevel" : "Fellow",
"citation" : "Furlan AJ, et al. \"Closure or medical therapy for cryptogenic stroke with patent foramen ovale\". The New England Journal of Medicine. 2012. 366(11):991-999.",
"subspecialties" : "Neurology;Cardiology",
"expansion" : "Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale",
"statusUsableDate" : "2013-01-01",
"briefResultsDescription" : "PFO closure does not reduce recurrent stroke",
"published" : "2012-03-15",
"pageName" : "CLOSURE I",
"diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
"abbreviation" : "CLOSURE I",
"title" : "Closure or medical therapy for cryptogenic stroke with patent foramen ovale",
"pmid" : "22417252"
},
{
"timestamp" : "2018-04-14T12:16:19Z",
"briefDesignDescription" : "LMWH vs. warfarin in cancer VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa025313",
"pageid" : 13,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa025313",
"trainingLevel" : "Intern",
"citation" : "Lee AY, et al. \"Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer\". The New England Journal of Medicine. 2003. 349(2):146-53.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "Comparison of Low Molecular Weight Heparin Versus Oral Anticoagulant Therapy for Long Term Anticoagulation in Cancer Patients With Venous Thromboembolism",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "LMWH reduces VTE recurrence in cancer VTE without increasing bleeding risk",
"published" : "2003-07-10",
"pageName" : "CLOT",
"diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "CLOT",
"title" : "Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer",
"pmid" : "12853587"
},
{
"timestamp" : "2021-04-29T17:37:05Z",
"briefDesignDescription" : "Mitra Clip for HF-related MR",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1806640",
"pageid" : 3714,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1806640",
"trainingLevel" : "Resident",
"citation" : "Stone GW, et al. \"Transcatheter Mitral Valve Repair in Patients with Heart Failure\". The New England Journal of Medicine. 2018. 379:2307-2318.",
"subspecialties" : "Cardiology",
"expansion" : "Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation",
"statusUsableDate" : "2018-12-19",
"briefResultsDescription" : "Mitra Clip reduces HF hospitalization rate in HF-related MR",
"published" : "2018-09-23",
"pageName" : "COAPT",
"diseases" : "Mitral Regurgitation",
"abbreviation" : "COAPT",
"title" : "Transcatheter Mitral Valve Repair in Patients with Heart Failure",
"pmid" : "30280640"
},
{
"timestamp" : "2017-12-03T22:34:23Z",
"briefDesignDescription" : "PPI plus clopidogrel in CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007964",
"pageid" : 313,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007964",
"trainingLevel" : "Resident",
"citation" : "Bhatt DL, et al. \"Clopidogrel with or without omeprazole in coronary artery disease\". The New England Journal of Medicine. 2010. 363(20):1909-17.",
"subspecialties" : "Cardiology",
"expansion" : "Clopidogrel and the Optimization of Gastrointestinal Events Trial",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "PPIs reduce bleeding but do not increase CV events when given with clopidogrel",
"published" : "2010-11-11",
"pageName" : "COGENT",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "COGENT",
"title" : "Clopidogrel with or without omeprazole in coronary artery disease",
"pmid" : "20925534"
},
{
"timestamp" : "2021-02-18T20:37:27Z",
"briefDesignDescription" : "Colchicine vs. placebo in ACS",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1912388",
"pageid" : 4145,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1912388",
"trainingLevel" : "Resident",
"citation" : "Tardif J, et al. \"Efficacy and safety of low-dose colchicine after myocardial infarction\". The New England Journal of Medicine. 2019. 381(26):2497-2505.",
"subspecialties" : "Cardiology",
"expansion" : "Colchicine Cardiovascular Outcomes Trial",
"statusUsableDate" : "2019-11-24",
"briefResultsDescription" : "Colchicine superior to placebo in ACS",
"published" : "2019-11-16",
"pageName" : "COLCOT",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "COLCOT",
"title" : "Efficacy and safety of low-dose colchicine after myocardial infarction",
"pmid" : "31733140"
},
{
"timestamp" : "2021-09-16T13:55:19Z",
"briefDesignDescription" : "FIT vs. colonoscopy for colon cancer screening",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1108895",
"pageid" : 2393,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1108895",
"trainingLevel" : "Resident",
"citation" : "Quintero E, et al. \"Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening\". The New England Journal of Medicine. 2012. 366(8):697-706.",
"subspecialties" : "Preventive Medicine;Gastroenterology;Oncology",
"expansion" : null,
"statusUsableDate" : "2016-07-01",
"briefResultsDescription" : "FIT is noninferior to colonoscopy for detecting colon cancer",
"published" : "2012-02-23",
"pageName" : "COLONPREV",
"diseases" : "Colorectal Cancer",
"abbreviation" : "COLONPREV",
"title" : "Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening",
"pmid" : "22356323"
},
{
"timestamp" : "2015-08-24T04:36:50Z",
"briefDesignDescription" : "Carvedilol vs. metoprolol in HFrEF",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)13800-7/fulltext",
"pageid" : 121,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603138007.pdf",
"trainingLevel" : "Resident",
"citation" : "Poole-Wilson PA, et al. \"Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial\". The Lancet. 2003. 362(9377):7-13.",
"subspecialties" : "Cardiology",
"expansion" : "Carvedilol Or Metoprolol European Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Carvedilol extends survival in HFrEF",
"published" : "2003-07-05",
"pageName" : "COMET",
"diseases" : "Heart Failure",
"abbreviation" : "COMET",
"title" : "Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial",
"pmid" : "12853193"
},
{
"timestamp" : "2018-03-08T18:56:18Z",
"briefDesignDescription" : "Metoprolol in acute MI",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67661-1/fulltext",
"pageid" : 1451,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673605676611.pdf",
"trainingLevel" : "Student",
"citation" : "Chen ZM, et al. \"Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial\". The Lancet. 2005. 366(9497):1622-1632.",
"subspecialties" : "Cardiology",
"expansion" : "ClOpidogrel and Metoprolol in Myocardial Infarction Trial / Second Chinese Cardiac Study",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "High-dose IV and PO metoprolol increases cardiogenic shock",
"published" : "2005-11-05",
"pageName" : "COMMIT",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "COMMIT/CCS-2",
"title" : "Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial",
"pmid" : "16271643"
},
{
"timestamp" : "2018-03-12T00:27:10Z",
"briefDesignDescription" : "Multivessel PCI vs. FFR-guided complete revascularization",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMc1706275",
"pageid" : 3543,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMc1706275",
"trainingLevel" : "Resident",
"citation" : "Smits PC, et al. \"Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction\". The New England Journal of Medicine. 2017. 376(13):1234-1244.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2018-03-11",
"briefResultsDescription" : "FFR-guided complete revascularization superior to infarct-related artery only PCI",
"published" : "2017-03-30",
"pageName" : "Compare-Acute",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "Compare-Acute",
"title" : "Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction",
"pmid" : "28745981"
},
{
"timestamp" : "2023-04-20T18:55:15Z",
"briefDesignDescription" : "Rivaroxaban, ASA, or both in stable CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1709118",
"pageid" : 2955,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1709118",
"trainingLevel" : "Resident",
"citation" : "Eikelboom JW et al. \"Rivaroxaban with or without aspirin in stable cardiovascular disease\". The New England Journal of Medicine. 2017. 377(14):1319-1330.",
"subspecialties" : "Cardiology",
"expansion" : "Cardiovascular Outcomes for People Using Anticoagulation Stratgies",
"statusUsableDate" : "2017-09-01",
"briefResultsDescription" : "Rivaroxaban + ASA superior to placebo + ASA for secondary prevention of CAD",
"published" : "2017-08-27",
"pageName" : "COMPASS",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "COMPASS",
"title" : "Rivaroxaban with or without aspirin in stable cardiovascular disease",
"pmid" : "28844192"
},
{
"timestamp" : "2021-02-20T21:38:07Z",
"briefDesignDescription" : "Enalapril in severe HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198706043162301",
"pageid" : 18,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198706043162301",
"trainingLevel" : "Intern",
"citation" : "CONSENSUS Trial Study Group. \"Effects of enalapril on mortality in severe congestive heart failure, results of the cooperative north Scandinavian enalapril survival study\". The New England Journal of Medicine. 1987. 316(23):1429-35.",
"subspecialties" : "Cardiology",
"expansion" : "Cooperative North Scandinavian Enalapril Survival Study",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Enalapril ↓mortality in NYHA class IV HFrEF",
"published" : "1987-06-04",
"pageName" : "CONSENSUS",
"diseases" : "Heart Failure",
"abbreviation" : "CONSENSUS",
"title" : "Effects of enalapril on mortality in severe congestive heart failure, results of the cooperative north Scandinavian enalapril survival study",
"pmid" : "2883575"
},
{
"timestamp" : "2014-06-13T04:33:43Z",
"briefDesignDescription" : "Carvedilol in HFrEF",
"fulltexturl" : "http://circ.ahajournals.org/content/106/17/2194.full",
"pageid" : 42,
"pdfurl" : "http://circ.ahajournals.org/content/106/17/2194.full.pdf",
"trainingLevel" : "Intern",
"citation" : "Packer M, et al. \"Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure\". Circulation. 2002. 106(17):2194-9.",
"subspecialties" : "Cardiology",
"expansion" : "Carvedilol Prospective Randomized Cumulative Survival",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Carvedilol reduces mortality and HF hospitalizations in severe NYHA class III-IV HFrEF",
"published" : "2002-10-22",
"pageName" : "COPERNICUS",
"diseases" : "Heart Failure",
"abbreviation" : "COPERNICUS",
"title" : "Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure",
"pmid" : "12390947"
},
{
"timestamp" : "2019-11-07T19:27:29Z",
"briefDesignDescription" : "Stenting vs. medical therapy in RAS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310753",
"pageid" : 2388,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310753",
"trainingLevel" : "Intern",
"citation" : "Cooper CJ, et al. \"Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis\". The New England Journal of Medicine. 2014. 370(1):13-22.",
"subspecialties" : "Nephrology;Cardiology",
"expansion" : "Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis",
"statusUsableDate" : "2019-11-07",
"briefResultsDescription" : "No difference in clinical outcomes",
"published" : "2014-01-02",
"pageName" : "CORAL",
"diseases" : "Cardiovascular Disease;Chronic Kidney Disease;Hypertension",
"abbreviation" : "CORAL",
"title" : "Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis",
"pmid" : "24245566"
},
{
"timestamp" : "2017-12-03T22:34:30Z",
"briefDesignDescription" : "Rosuvastatin in ischemic HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706201",
"pageid" : 524,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706201",
"trainingLevel" : "Resident",
"citation" : "Kjekshus J, et al. \"Rosuvastatin in Older Patients with Systolic Heart Failure\". The New England Journal of Medicine. 2007. 357(22):2248-61.",
"subspecialties" : "Cardiology",
"expansion" : "Controlled Rosuvastatin Multinational Trial in Heart Failure",
"statusUsableDate" : "2012-07-01",
"briefResultsDescription" : "Statins confer no survival benefit but may reduce hospitalizations in ischemic HFrEF",
"published" : "2007-11-29",
"pageName" : "CORONA",
"diseases" : "Heart Failure;Hyperlipidemia",
"abbreviation" : "CORONA",
"title" : "Rosuvastatin in Older Patients with Systolic Heart Failure",
"pmid" : "17984166"
},
{
"timestamp" : "2018-03-03T22:13:51Z",
"briefDesignDescription" : "Hydrocortisone in septic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa071366",
"pageid" : 4,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa071366",
"trainingLevel" : "Student",
"citation" : "Sprung CL, et al. \"Hydrocortisone therapy for patients with septic shock\". New England Journal of Medicine. 2008. 358(2):111-24.",
"subspecialties" : "Critical Care;Endocrinology",
"expansion" : "Corticosteroid Therapy of Septic Shock",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Improved survival of hydrocortisone in septic shock",
"published" : "2008-01-10",
"pageName" : "CORTICUS",
"diseases" : "Sepsis;Shock",
"abbreviation" : "CORTICUS",
"title" : "Hydrocortisone therapy for patients with septic shock",
"pmid" : "18184957"
},
{
"timestamp" : "2017-12-14T14:38:53Z",
"briefDesignDescription" : "PCI vs. medical therapy in CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa070829",
"pageid" : 21,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa070829",
"trainingLevel" : "Student",
"citation" : "Boden WE, et al. \"Optimal medical therapy with or without PCI for stable coronary disease\". The New England Journal of Medicine. 2007. 356:1503-16.",
"subspecialties" : "Cardiology",
"expansion" : "Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No difference between PCI and OMT in stable CAD",
"published" : "2007-04-12",
"pageName" : "COURAGE",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "COURAGE",
"title" : "Optimal medical therapy with or without PCI for stable coronary disease",
"pmid" : "17387127"
},
{
"timestamp" : "2017-12-03T22:34:43Z",
"briefDesignDescription" : "Cranberry in for prevention of pyuria and bacteriuria",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.16141",
"pageid" : 2900,
"pdfurl" : "",
"trainingLevel" : "student",
"citation" : "Juthani-Mehta M, et al. \"Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial\". JAMA. 2016. 316(18):1879-1887.",
"subspecialties" : "Infectious Disease;Geriatrics",
"expansion" : "",
"statusUsableDate" : "2017-04-01",
"briefResultsDescription" : "Cranberry ineffective to prevent pyuria and bacteriuria",
"published" : "2016-11-08",
"pageName" : "Cranberry for prevention of pyuria and bacteriuria",
"diseases" : "Bacteriuria;Pyuria",
"abbreviation" : "",
"title" : "Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial",
"pmid" : "27787564"
},
{
"timestamp" : "2022-12-01T18:56:37Z",
"briefDesignDescription" : "Tranexamic acid in trauma",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960835-5/fulltext",
"pageid" : 490,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673610608355.pdf",
"trainingLevel" : "resident",
"citation" : "Shakur H, et al. \"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage\". The Lancet. 2010. 376(9734):23-32.",
"subspecialties" : "Emergency Medicine;Surgery;Hematology",
"expansion" : "Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Tranexamic acid reduces 4-week mortality",
"published" : "2010-07-03",
"pageName" : "CRASH-2",
"diseases" : "Trauma",
"abbreviation" : "CRASH-2",
"title" : "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage",
"pmid" : "20554319"
},
{
"timestamp" : "2022-06-17T05:34:20Z",
"briefDesignDescription" : "Ide-cel CART in myeloma",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1817226",
"pageid" : 4096,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817226",
"trainingLevel" : "Fellow",
"citation" : "Raje N, et al. \"Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma\". The New England Journal of Medicine. 2019. 380(18):1726-1737.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2022-06-16",
"briefResultsDescription" : "CRS 76%, ORR 85%, PFS 11.8 months",
"published" : "2019-05-02",
"pageName" : "CRB-401",
"diseases" : "Multiple Myeloma",
"abbreviation" : "CRB-401",
"title" : "Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma",
"pmid" : "31042825"
},
{
"timestamp" : "2019-10-15T19:28:09Z",
"briefDesignDescription" : "Canagliflozin in diabetic nephropathy",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1811744",
"pageid" : 4088,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1811744",
"trainingLevel" : "Resident",
"citation" : "Perkovic V, et al. \"Canagliflozin and renal outcomes in diabetic nephropathy\". The New England Journal of Medicine. 2019. 380(24):2295-2306.",
"subspecialties" : "Endocrinology;Nephrology",
"expansion" : "Canagliflozin and Renal Events in Diabetes and Nephropathy Clinical Evaluation",
"statusUsableDate" : "2019-07-31",
"briefResultsDescription" : "Canagliflozin reduces renal and CVD endpoints vs. placebo",
"published" : "2019-06-13",
"pageName" : "CREDENCE",
"diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
"abbreviation" : "CREDENCE",
"title" : "Canagliflozin and renal outcomes in diabetic nephropathy",
"pmid" : "30990260"
},
{
"timestamp" : "2019-01-30T21:43:56Z",
"briefDesignDescription" : "Stenting vs. CEA in carotid stenosis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0912321",
"pageid" : 492,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0912321",
"trainingLevel" : "Intern",
"citation" : "Brott TG, et al. \"Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis\". The New England Journal of Medicine. 2010. 363(1):11-23.",
"subspecialties" : "Surgery;Neurology;Cardiology",
"expansion" : "Carotid Revascularization Endarterectomy vs. Stenting Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No difference in stroke/MI/death; stenting ↑perioperative stroke but ↓perioperative MI",
"published" : "2010-07-01",
"pageName" : "CREST",
"diseases" : "Carotid Stenosis;Stroke;Transient Ischemic Attack",
"abbreviation" : "CREST",
"title" : "Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis",
"pmid" : "20505173"
},
{
"timestamp" : "2017-12-03T22:34:32Z",
"briefDesignDescription" : "Colloids vs. crystalloids in shock",
"fulltexturl" : "http://bit.ly/1kLbQWJ",
"pageid" : 1768,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/928522/joi130081.pdf",
"trainingLevel" : "resident",
"citation" : "Annane D, et al. \"Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock\". The Journal of the American Medical Association. 2013. 310(17):1809-1817.",
"subspecialties" : "Critical Care",
"expansion" : "Colloids Versus Crystalloids for the Resuscitation of the Critically Ill",
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Colloids no different from crystalloids in mortality",
"published" : "2013-11-06",
"pageName" : "CRISTAL",
"diseases" : "Shock",
"abbreviation" : "CRISTAL",
"title" : "Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock",
"pmid" : "24108515"
},
{
"timestamp" : "2021-04-22T22:10:39Z",
"briefDesignDescription" : "Captopril in T1DM nephropathy",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199311113292004",
"pageid" : 1591,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199311113292004",
"trainingLevel" : "Student",
"citation" : "Lewis EJ, et al. \"The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.\". The New England Journal of Medicine. 1993. 329(20):1456-1462.",
"subspecialties" : "Nephrology;Endocrinology",
"expansion" : "Collaborative Study Group Captopril Trial",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Captopril reduces T1DM nephropathy progression",
"published" : "1993-11-11",
"pageName" : "CSG Captopril Trial",
"diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
"abbreviation" : "CSG Captopril Trial",
"title" : "The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.",
"pmid" : "8413456"
},
{
"timestamp" : "2018-08-28T15:50:00Z",
"briefDesignDescription" : "Culprit-only vs. multivessel PCI in cardiogenic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1710261#t",
"pageid" : 2977,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1710261#t",
"trainingLevel" : "Resident",
"citation" : "Thiele H, et al. \"PCI strategies in patients with acute myocardial infarction and cardiogenic shock\". New England Journal of Medicine. 2017. epub 2017-10-30:1-13.",
"subspecialties" : "Cardiology",
"expansion" : "Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock",
"statusUsableDate" : "2017-11-01",
"briefResultsDescription" : "Culprit-only PCI superior to multivessel PCI in cardiogenic shock",
"published" : "2017-10-30",
"pageName" : "CULPRIT-SHOCK",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "CULPRIT-SHOCK",
"title" : "PCI strategies in patients with acute myocardial infarction and cardiogenic shock",
"pmid" : "29083953"
},
{
"timestamp" : "2017-12-03T22:34:36Z",
"briefDesignDescription" : "Clopidogrel in UA/NSTEMI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010746",
"pageid" : 921,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010746",
"trainingLevel" : "Resident",
"citation" : "Yusuf S, et al. \"Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation\". The New England Journal of Medicine. 2001. 345(7):494-502.",
"subspecialties" : "Cardiology",
"expansion" : "Clopidogrel in Unstable Angina to Prevent Recurrent Events",
"statusUsableDate" : "2012-12-01",
"briefResultsDescription" : "Clopidogrel reduces CV events but increases bleeding in UA/NSTEMI",
"published" : "2001-08-16",
"pageName" : "CURE",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "CURE",
"title" : "Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation",
"pmid" : "11519503"
},
{
"timestamp" : "2017-12-03T22:34:45Z",
"briefDesignDescription" : "Culprit lesion-only vs. complete revascularization",
"fulltexturl" : "http://www.onlinejacc.org/content/65/10/963",
"pageid" : 2880,
"pdfurl" : "http://www.onlinejacc.org/content/accj/65/10/963.full.pdf?download",
"trainingLevel" : "Resident",
"citation" : "Gershlick et al. \"Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease\". J Am Coll Cardiol. 2015. 65(10):963-72.",
"subspecialties" : "Cardiology",
"expansion" : "Complete Versus Lesion-Only Primary PCI Trial",
"statusUsableDate" : "2017-02-01",
"briefResultsDescription" : "Complete revascularization superior to culprit lesion-only revascularization",
"published" : "2015-03-17",
"pageName" : "CvLPRIT",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "CvLPRIT",
"title" : "Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease",
"pmid" : "25766941"
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{
"timestamp" : "2017-12-03T22:34:37Z",
"briefDesignDescription" : "Pulse cyclophosphamide for ANCA vasculitis",
"fulltexturl" : null,
"pageid" : 2338,
"pdfurl" : "http://annals.org/data/Journals/AIM/20182/0000605-200905190-00004.pdf",
"trainingLevel" : "Fellow",
"citation" : "de Groot K, et al. \"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial\". Annals of Internal Medicine. 2009. 150(10):670-680.",
"subspecialties" : "Rheumatology;Nephrology",
"expansion" : null,
"statusUsableDate" : "2015-03-01",
"briefResultsDescription" : "Pulse no worse than daily cyclophosphamide",
"published" : "2009-05-19",
"pageName" : "CYCLOPS",
"diseases" : "Vasculitis",
"abbreviation" : "CYCLOPS",
"title" : "Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial",
"pmid" : "19451574"
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{
"timestamp" : "2018-01-13T01:32:16Z",
"briefDesignDescription" : "Cytisine vs. NRT for tobacco abuse",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407764",
"pageid" : 2319,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407764",
"trainingLevel" : "Intern",
"citation" : "Walker N, et al. \"Cytisine versus nicotine for smoking cessation\". The New England Journal of Medicine. 2014. 371(25):2353-2362.",
"subspecialties" : "Pulmonology;Preventive Medicine",
"expansion" : null,
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Cytisine superior to NRT for abstinence at 1 month",
"published" : "2014-12-18",
"pageName" : "Cytisine for Smoking Cessation",
"diseases" : "Tobacco Abuse",
"abbreviation" : null,
"title" : "Cytisine versus nicotine for smoking cessation",
"pmid" : "25517706"
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{
"timestamp" : "2017-12-03T22:34:39Z",
"briefDesignDescription" : "Hematocrit thresholds in PV",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208500",
"pageid" : 2709,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208500",
"trainingLevel" : "Fellow",
"citation" : "Marchioli R, et al. \"Cardiovascular events and intensity of treatment in polycythemia vera\". The New England Journal of Medicine. 2013. 368(1):22-33.",
"subspecialties" : "Hematology;Cardiology",
"expansion" : "Cytoreductive Therapy in Polycythemia Vera",
"statusUsableDate" : "2016-02-01",
"briefResultsDescription" : "Fewer vascular events with hematocrit <45% compared to 45-50%",
"published" : "2013-01-03",
"pageName" : "CYTO-PV",
"diseases" : "Polycythemia Vera;Myeloproliferative Neoplasms",
"abbreviation" : "CYTO-PV",
"title" : "Cardiovascular events and intensity of treatment in polycythemia vera",
"pmid" : "23216616"
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{
"timestamp" : "2017-12-03T22:35:01Z",
"briefDesignDescription" : "Scheduled daily sedation holidays in intubated patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200005183422002",
"pageid" : 1554,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200005183422002",
"trainingLevel" : "Intern",
"citation" : "Kress JP, et al. \"Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation\". The New England Journal of Medicine. 2000. 342(20):1471-1477.",
"subspecialties" : "Critical Care;Pulmonology",
"expansion" : "",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Sedation holidays reduce intubated, ICU, hospital days",
"published" : "2000-05-18",
"pageName" : "Daily ICU Sedation Holidays",
"diseases" : "Respiratory Failure",
"abbreviation" : "",
"title" : "Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation",
"pmid" : "10816184"
},
{
"timestamp" : "2018-05-31T17:39:19Z",
"briefDesignDescription" : "Culprit lesion PCI vs. FFR in multivessel CAD",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60648-1/fulltext",
"pageid" : 3634,
"pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60648-1.pdf",
"trainingLevel" : "Resident",
"citation" : "Engstrom T, et al. \"Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease\". The Lancet. 2015. 386:665-71.",
"subspecialties" : "Cardiology",
"expansion" : "Third Danish Study of Optimal Acute Treatment of Patients with STEMI: Primary PCI in Multivessel Disease",
"statusUsableDate" : "2018-05-28",
"briefResultsDescription" : "FFR-guided revascularization was superior to culprit-lesion only in multivessel CAD",
"published" : "2015-08-15",
"pageName" : "DANAMI-3 PRIMULTI",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "DANAMI-3 PRIMULTI",
"title" : "Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease",
"pmid" : "26347918"
},
{
"timestamp" : "2017-12-03T22:34:48Z",
"briefDesignDescription" : "ICD vs. standard care in NICM and LVEF ≤35%",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1608029",
"pageid" : 2815,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1608029",
"trainingLevel" : "Resident",
"citation" : "Kober L, et al. \"Defibrillator implantation in patients with nonischemic systolic heart failure\". The New England Journal of Medicine. 2016. epub 2016-08-28:1-10.",
"subspecialties" : "Cardiology",
"expansion" : "Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality",
"statusUsableDate" : "2016-09-01",
"briefResultsDescription" : "ICD not better than standard of care in NICM and LVEF ≤35%",
"published" : "2016-08-28",
"pageName" : "DANISH",
"diseases" : "Ventricular Tachycardia",
"abbreviation" : "DANISH",
"title" : "Defibrillator implantation in patients with nonischemic systolic heart failure",
"pmid" : "27571011"
},
{
"timestamp" : "2021-05-28T02:47:35Z",
"briefDesignDescription" : "Dapagliflozin in CKD±T2DM",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2024816",
"pageid" : 4363,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024816",
"trainingLevel" : "resident",
"citation" : "Heerspink, et al. \"Dapagliflozin in patients with chronic kidney disease\". The New England Journal of Medicine. 2020. 383(13):1436-1446.",
"subspecialties" : "Nephrology;Cardiology",
"expansion" : "Dapagliflozin in Chronic Kidney Disease",
"statusUsableDate" : "2020-10-29",
"briefResultsDescription" : "Dapagliflozin in CKD reduces renal endpoints and CVD death",
"published" : "2020-10-08",
"pageName" : "DAPA-CKD",
"diseases" : "Chronic Kidney Disease",
"abbreviation" : "DAPA-CKD",
"title" : "Dapagliflozin in patients with chronic kidney disease",
"pmid" : "32970396"
},
{
"timestamp" : "2022-10-13T18:58:46Z",
"briefDesignDescription" : "Dapagliflozin in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1911303",
"pageid" : 4113,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1911303",
"trainingLevel" : "Resident",
"citation" : "McMurray JJV, et al. \"Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction\". The New England Journal of Medicine. 2019. 381(21):1995-2008.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "Dapagliflozin in Heart Failure",
"statusUsableDate" : "2019-12-12",
"briefResultsDescription" : "Dapagliflozin reduces CV complications in HFrEF",
"published" : "2019-11-21",
"pageName" : "DAPA-HF",
"diseases" : "Heart Failure",
"abbreviation" : "DAPA-HF",
"title" : "Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction",
"pmid" : "31535829"
},
{
"timestamp" : "2017-12-03T22:34:50Z",
"briefDesignDescription" : "Aspirin/clopidogrel duration after PCI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409312",
"pageid" : 2264,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409312",
"trainingLevel" : "Intern",
"citation" : "Mauri L, et al. \"Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents\". The New England Journal of Medicine. 2014. 371(23):2155-2166.",
"subspecialties" : "Cardiology",
"expansion" : "Dual Antiplatelet Therapy",
"statusUsableDate" : "2014-11-01",
"briefResultsDescription" : "Longer duration reduces stent thrombosis, MI, stroke, but increases mortality/bleeding",
"published" : "2014-11-16",
"pageName" : "DAPT",
"diseases" : "Coronary Artery Disease;Myocardial Infarction;Stroke",
"abbreviation" : "DAPT",
"title" : "Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents",
"pmid" : "25399658"
},
{
"timestamp" : "2020-09-22T18:22:21Z",
"briefDesignDescription" : "DASH diet in HTN",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199704173361601",
"pageid" : 90,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199704173361601",
"trainingLevel" : "Student",
"citation" : "Appel LJ, et al. \"A clinical trial of the effects of dietary patterns on blood pressure\". The New England Journal of Medicine. 1997. 336(16):1117-1124.",
"subspecialties" : "Cardiology;Nephrology",
"expansion" : "Dietary Approaches to Stop Hypertension",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "DASH diet reduces SBP and DBP",
"published" : "1997-04-17",
"pageName" : "DASH",
"diseases" : "Hypertension",
"abbreviation" : "DASH",
"title" : "A clinical trial of the effects of dietary patterns on blood pressure",
"pmid" : "9099655"
},
{
"timestamp" : "2017-12-03T22:34:54Z",
"briefDesignDescription" : "Dual-chamber vs. ventricular backup pacing in ICD patients",
"fulltexturl" : "http://jama.jamanetwork.com/article.aspx?volume",
"pageid" : 2713,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Wilkoff BL, et al. \"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator\". Journal of the American Medical Association. 2002. 288(24):3115-3123.",
"subspecialties" : "Cardiology",
"expansion" : "Dual-chamber pacing or ventricular backup pacing in ICD patients",
"statusUsableDate" : "2016-08-01",
"briefResultsDescription" : "Ventricular backup pacemaker superior to dual-chamber pacemaker",
"published" : "2002-12-25",
"pageName" : "DAVID",
"diseases" : "Bradycardia",
"abbreviation" : "DAVID",
"title" : "Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator",
"pmid" : "12495391"
},
{
"timestamp" : "2020-01-25T11:34:00Z",
"briefDesignDescription" : "Thrombectomy 6-24 hours after stroke",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1706442",
"pageid" : 3529,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1706442",
"trainingLevel" : "Resident",
"citation" : "Nogueira RG, et al. \"Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct\". The New England Journal of Medicine. 2018. 378(1):11-21.",
"subspecialties" : "Neurology",
"expansion" : "DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo",
"statusUsableDate" : "2020-01-23",
"briefResultsDescription" : "Thrombectomy improved 90-day outcomes compared to standard care",
"published" : "2018-01-04",
"pageName" : "DAWN",
"diseases" : "Stroke",
"abbreviation" : "DAWN",
"title" : "Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct",
"pmid" : "29129157"
},
{
"timestamp" : "2012-09-16T11:23:12Z",
"briefDesignDescription" : "Intensive glycemic therapy in T1DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309303291401",
"pageid" : 135,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309303291401",
"trainingLevel" : "Student",
"citation" : "DCCT Research Group. \"The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus\". The New England Journal of Medicine. 1993. 329(14):977-986.",
"subspecialties" : "Endocrinology",
"expansion" : "Diabetes Control and Complications Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Intensive therapy delays microvascular but not macrovascular complications in T1DM",
"published" : "1993-09-30",
"pageName" : "DCCT",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "DCCT",
"title" : "The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus",
"pmid" : "8366922"
},
{
"timestamp" : "2014-06-13T04:45:33Z",
"briefDesignDescription" : "ICD vs. medical therapy in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa033088",
"pageid" : 84,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa033088",
"trainingLevel" : "Resident",
"citation" : "Kadish A, et al. \"Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy\". The New England Journal of Medicine. 2004. 350(21):2151-2158.",
"subspecialties" : "Cardiology",
"expansion" : "Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "ICD reduced risk of arrhythmogenic sudden death, but not overall mortality",
"published" : "2004-05-20",
"pageName" : "DEFINITE",
"diseases" : "Heart Failure",
"abbreviation" : "DEFINITE",
"title" : "Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy",
"pmid" : "15152060"
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{
"timestamp" : "2021-10-04T20:25:15Z",
"briefDesignDescription" : "Ramelteon vs. placebo to prevent delirium",
"fulltexturl" : "http://jamanetwork.com/journals/jamapsychiatry/fullarticle/1831407",
"pageid" : 2806,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Hatta K, et al. \"Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial\". JAMA Psychiatry. 2014. 71(4):397-403.",
"subspecialties" : "Psychiatry;Geriatrics",
"expansion" : "Delirium Intervention Research for Improving Acute phase outcomes in Japan",
"statusUsableDate" : "2021-09-30",
"briefResultsDescription" : "Ramelteon decreased risk of delirium in elderly patients",
"published" : "2014-04-01",
"pageName" : "DELIRIA-J",
"diseases" : "Delirium",
"abbreviation" : "DELIRIA-J",
"title" : "Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial",
"pmid" : "24554232"
},
{
"timestamp" : "2023-05-04T03:39:40Z",
"briefDesignDescription" : "Dapagliflozin in HFmrEF or HFpEF",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2206286",
"pageid" : 4921,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2206286",
"trainingLevel" : "Resident",
"citation" : "Solomon SD, et al. \"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction\". The New England Journal of Medicine. 2022. 387(12):1089-1098.",
"subspecialties" : "Cardiology",
"expansion" : "Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure",
"statusUsableDate" : "2022-10-13",
"briefResultsDescription" : "Dapagliflozin reduces HF events in HFmrEF or HFpEF",
"published" : "2022-09-22",
"pageName" : "DELIVER",
"diseases" : "Heart Failure",
"abbreviation" : "DELIVER",
"title" : "Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction",
"pmid" : "36027570"
},
{
"timestamp" : "2018-02-01T20:15:39Z",
"briefDesignDescription" : "Oxygen for suspected MI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1706222",
"pageid" : 2970,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1706222",
"trainingLevel" : "Student",
"citation" : "Hofmann R, et al. \"Oxygen therapy in suspected acute myocardial infarction\". The New England Journal of Medicine. 2017. 377(13):1240-1249.",
"subspecialties" : "Cardiology",
"expansion" : "Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction",
"statusUsableDate" : "2017-10-01",
"briefResultsDescription" : "Oxygen doesn't improve 1 year survival in MI",
"published" : "2017-09-28",
"pageName" : "DETO2X-AMI",
"diseases" : "Myocardial Infarction",
"abbreviation" : "DETO2X-AMI",
"title" : "Oxygen therapy in suspected acute myocardial infarction",
"pmid" : "28844200"
},
{
"timestamp" : "2014-06-13T04:50:56Z",
"briefDesignDescription" : "Digoxin in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199702203360801",
"pageid" : 89,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199702203360801",
"trainingLevel" : "Resident",
"citation" : "Gorlin R, et al. \"The effect of digoxin on mortality and morbidity in patients with heart failure\". The New England Journal of Medicine. 1997. 336(8):525-533.",
"subspecialties" : "Cardiology",
"expansion" : "Digitalis Investigation Group",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Reduced hospitalizations, no mortality benefit",
"published" : "1997-02-20",
"pageName" : "DIG",
"diseases" : "Heart Failure",
"abbreviation" : "DIG",
"title" : "The effect of digoxin on mortality and morbidity in patients with heart failure",
"pmid" : "9036306"
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{
"timestamp" : "2020-09-14T19:26:41Z",
"briefDesignDescription" : "ICD for ICM shortly after MI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041489",
"pageid" : 1743,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041489",
"trainingLevel" : "Resident",
"citation" : "Hohnloser SH, et al. \"Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction\". The New England Journal of Medicine. 2004. 351(24):2481-2488.",
"subspecialties" : "Cardiology",
"expansion" : "Defibrillator in Acute Myocardial Infarction Trial",
"statusUsableDate" : "2016-04-01",
"briefResultsDescription" : "ICD reduces arrhythmia but not mortality",
"published" : "2004-12-09",
"pageName" : "DINAMIT",
"diseases" : "Heart Failure;Myocardial Infarction",
"abbreviation" : "DINAMIT",
"title" : "Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction",
"pmid" : "15590950"
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{
"timestamp" : "2019-10-17T17:40:21Z",
"briefDesignDescription" : "BMS vs. DES for saphenous vein graft PCI",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30801-8/fulltext",
"pageid" : 3743,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Brilakis ES, et al. \"Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial\". Lancet. 2018. 391(10134):1997-2007.",
"subspecialties" : "Cardiology",
"expansion" : "Rationale and design of the drug-eluting stents vs bare-metal stents in saphenous vein graft angioplasty",
"statusUsableDate" : "2018-11-27",
"briefResultsDescription" : "BMS noninferior to DES for saphenous vein graft PCI",
"published" : "2018-05-19",
"pageName" : "DIVA",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "DIVA",
"title" : "Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial",
"pmid" : "29759512"
},
{
"timestamp" : "2019-07-18T20:41:06Z",
"briefDesignDescription" : "D-dimer based anticoagulation discontinuation",
"fulltexturl" : "https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14458",
"pageid" : 4089,
"pdfurl" : "https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14458",
"trainingLevel" : "Fellow",
"citation" : "Kearon C, et al. \"Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study\". Journal of Thrombosis and Hemostasis. 2019. 17(7):1144-52.",
"subspecialties" : "Hematology",
"expansion" : "D-dimer Optimal Duration Study",
"statusUsableDate" : "2019-07-18",
"briefResultsDescription" : "D-dimer based discontinuation effective in women, not for men",
"published" : "2019-01-18",
"pageName" : "DODS",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"abbreviation" : "DODS",
"title" : "Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study",
"pmid" : "31033194"
},
{
"timestamp" : "2019-05-23T17:58:08Z",
"briefDesignDescription" : "Donor HCV positive heart and lung transplant",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812406",
"pageid" : 4066,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812406",
"trainingLevel" : "Resident",
"citation" : "Woolley AE, et al. \"Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients\". The New England Journal of Medicine. 2019. 380(17):1606-1617.",
"subspecialties" : "Cardiology",
"expansion" : "Donors of Hepatitis C NAT Positive Thoracic Allografts for Transplantation Evaluation in Non-HCV Recipients",
"statusUsableDate" : "2019-05-17",
"briefResultsDescription" : "Donor HCV+ heart & lung transplant is feasible",
"published" : "2019-04-25",
"pageName" : "DONATE-HCV",
"diseases" : "Heart Failure;Respiratory Failure",
"abbreviation" : "DONATE HCV",
"title" : "Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients",
"pmid" : "30946553"
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{
"timestamp" : "2022-09-15T20:00:28Z",
"briefDesignDescription" : "Diuretic dosing in acute HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005419",
"pageid" : 1457,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005419",
"trainingLevel" : "Intern",
"citation" : "Felker GM, et al. \"Diuretic strategies in patients with acute decompensated heart failure\". The New England Journal of Medicine. 2011. 364(9):797-805.",
"subspecialties" : "Cardiology",
"expansion" : "Diuretic Optimization Strategies Evaluation",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "High-dose better than low-dose, continuous infusions no better than intermittent IV boluses",
"published" : "2011-03-03",
"pageName" : "DOSE",
"diseases" : "Heart Failure",
"abbreviation" : "DOSE",
"title" : "Diuretic strategies in patients with acute decompensated heart failure",
"pmid" : "21366472"
},
{
"timestamp" : "2018-05-31T18:34:46Z",
"briefDesignDescription" : "Metformin and intensive lifestyle in prediabetes",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa012512",
"pageid" : 2494,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa012512",
"trainingLevel" : "Student",
"citation" : "Knowler WC, et al. \"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin\". The New England Journal of Medicine. 2002. 346(6):393-403.",
"subspecialties" : "Endocrinology",
"expansion" : "Diabetes Prevention Program",
"statusUsableDate" : "2018-05-31",
"briefResultsDescription" : "Metformin and intensive lifestyle reduce incidence of diabetes",
"published" : "2002-02-07",
"pageName" : "DPP",
"diseases" : "Prediabetes;Diabetes Mellitus",
"abbreviation" : "DPP",
"title" : "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin",
"pmid" : "11832527"
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{
"timestamp" : "2017-12-03T22:35:03Z",
"briefDesignDescription" : "Duct tape vs. cryotherapy for warts",
"fulltexturl" : "",
"pageid" : 1579,
"pdfurl" : "http://archpedi.jamanetwork.com/data/Journals/PEDS/5052/POA20075.pdf",
"trainingLevel" : "Student",
"citation" : "Focht DR, et al. \"The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)\". Archives of Pediatric and Adolescent Medicine. 2002. 156:971-974.",
"subspecialties" : "Pediatrics;Dermatology",
"expansion" : "",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Duct tape superior to cryotherapy for wart resolution",
"published" : "2002-10-01",
"pageName" : "Duct Tape for Treatment of the Common Wart",
"diseases" : "Warts",
"abbreviation" : "",
"title" : "The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)",
"pmid" : "12361440"
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{
"timestamp" : "2018-03-29T18:30:43Z",
"briefDesignDescription" : "Fecal transplant in C. difficile",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205037",
"pageid" : 1226,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205037",
"trainingLevel" : "Intern",
"citation" : "Van Nood E, et al. \"Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile\". The New England Journal of Medicine. 2013. 368(5):407-415.",
"subspecialties" : "Gastroenterology;Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2013-02-01",
"briefResultsDescription" : "Fecal transplant better than vancomycin in C. difficile",
"published" : "2013-01-31",
"pageName" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
"diseases" : "Clostridium difficile",
"abbreviation" : "",
"title" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
"pmid" : "23323867"
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{
"timestamp" : "2017-12-03T22:35:32Z",
"briefDesignDescription" : "Palliative care in NSCLC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000678",
"pageid" : 466,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000678",
"trainingLevel" : "Intern",
"citation" : "Temel JS, et al. \"Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer\". The New England Journal of Medicine. 2010. 363(8):733-742.",
"subspecialties" : "Oncology;Palliative Care",
"expansion" : null,
"statusUsableDate" : "2012-06-01",
"briefResultsDescription" : "Palliative care ↑mood, ↑QOL, ↑survival, ↓aggressive care",
"published" : "2010-08-19",
"pageName" : "Early Palliative Care",
"diseases" : "Lung Cancer",
"abbreviation" : null,
"title" : "Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer",
"pmid" : "20818875"
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{
"timestamp" : "2018-08-30T17:24:07Z",
"briefDesignDescription" : "Early TIPS in high-risk cirrhotic variceal bleeding",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910102",
"pageid" : 2661,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910102",
"trainingLevel" : "Resident",
"citation" : "García-Pagán JC, et al. \"Early use of TIPS in patients with cirrhosis and variceal bleeding\". The New England Journal of Medicine. 2010. 362(25):2370-2379.",
"subspecialties" : "Gastroenterology;Interventional Radiology",
"expansion" : "",
"statusUsableDate" : "2018-08-30",
"briefResultsDescription" : "Early TIPS reduces rates of treatment failure and improves 1-year survival",
"published" : "2010-06-24",
"pageName" : "Early TIPS",
"diseases" : "Cirrhosis;Gastrointestinal Hemorrhage",
"abbreviation" : "Early TIPS",
"title" : "Early use of TIPS in patients with cirrhosis and variceal bleeding",
"pmid" : "20573925"
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{
"timestamp" : "2021-11-08T18:52:31Z",
"briefDesignDescription" : "Cryoablation vs. antiarrhythmics in AF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
"pageid" : 4406,
"pdfurl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
"trainingLevel" : "Resident",
"citation" : "Andrade J, et al. \"Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation\". The New England Journal of Medicine. 2021. 384(4):305-315.",
"subspecialties" : "Cardiology",
"expansion" : "Early Aggressive Invasive Intervention for Atrial Fibrillation",
"statusUsableDate" : "2021-10-14",
"briefResultsDescription" : "Cryoablation with lower tachyarrhythmia recurrence than antiarrhythmics.",
"published" : "2021-01-28",
"pageName" : "EARLY-AF",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "EARLY-AF",
"title" : "Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation",
"pmid" : "33197159"
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{
"timestamp" : "2019-09-19T17:42:49Z",
"briefDesignDescription" : "Early surgery in endocarditis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112843",
"pageid" : 2939,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112843",
"trainingLevel" : "Resident",
"citation" : "Kang DH, et al. \"Early surgery versus conventional treatment for infective endocarditis\". The New England Journal of Medicine. 2012. 366(26):2466-73.",
"subspecialties" : "Cardiology;Infectious Disease;Surgery",
"expansion" : "Early Surgery versus Conventional Treatment in Infective Endocarditis",
"statusUsableDate" : "2019-09-19",
"briefResultsDescription" : "Early surgery improves outcomes in infective endocarditis",
"published" : "2012-06-28",
"pageName" : "EASE",
"diseases" : "Endocarditis",
"abbreviation" : "EASE",
"title" : "Early surgery versus conventional treatment for infective endocarditis",
"pmid" : "22738096"
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{
"timestamp" : "2021-02-09T14:57:23Z",
"briefDesignDescription" : "Early rhythm vs. rate control in AF",
"fulltexturl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
"pageid" : 4399,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
"trainingLevel" : "Resident",
"citation" : "Kirchhof P, et al. \"Early rhythm-control therapy in patients with atrial fibrillation\". The New England Journal of Medicine. 2020. 383(14):1305-1316.",
"subspecialties" : "Cardiology",
"expansion" : "The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial",
"statusUsableDate" : "2021-01-28",
"briefResultsDescription" : "Early rhythm control with fewer CVD events.",
"published" : "2020-10-01",
"pageName" : "EAST-AFNET 4",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "EAST-AFNET 4",
"title" : "Early rhythm-control therapy in patients with atrial fibrillation",
"pmid" : "32865375"
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{
"timestamp" : "2017-04-20T01:11:46Z",
"briefDesignDescription" : "Alteplase 3-4.5h after stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804656",
"pageid" : 115,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804656",
"trainingLevel" : "Intern",
"citation" : "Hacke W, et al. \"Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke\". The New England Journal of Medicine. 2008. 359(13):1317-1329.",
"subspecialties" : "Neurology",
"expansion" : "European Cooperative Acute Stroke Study III",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Alteplase improves neurological outcomes at 3 months",
"published" : "2008-09-25",
"pageName" : "ECASS III",
"diseases" : "Stroke",
"abbreviation" : "ECASS III",
"title" : "Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke",
"pmid" : "18815396"
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{
"timestamp" : "2020-08-01T19:26:48Z",
"briefDesignDescription" : "CEA in symptomatic carotid stenosis",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2909292-1",
"pageid" : 2354,
"pdfurl" : "",
"trainingLevel" : "Intern",
"citation" : "ECST Writers. \"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)\". The Lancet. 1998. 351(9113):1379-1387.",
"subspecialties" : "Surgery;Neurology",
"expansion" : "European Carotid Surgery Trial",
"statusUsableDate" : "2015-08-01",
"briefResultsDescription" : "CEA improves outcomes in patients with ≥80% symptomatic carotid stenosis",
"published" : "1998-05-09",
"pageName" : "ECST",
"diseases" : "Carotid Stenosis;Stroke",
"abbreviation" : "ECST",
"title" : "Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)",
"pmid" : "9593407"
},
{
"timestamp" : "2013-03-12T08:18:42Z",
"briefDesignDescription" : "Intensive glycemic therapy in T1DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052187",
"pageid" : 136,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052187",
"trainingLevel" : "intern",
"citation" : "Nathan DM, et al. \"Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes\". The New England Journal of Medicine. 2005. 353(25):2643-2653.",
"subspecialties" : "Endocrinology",
"expansion" : "Epidemiology of Diabetes Interventions and Complications",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Intensive therapy associated with fewer cardiovascular complications",
"published" : "2005-12-22",
"pageName" : "EDIC",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "EDIC",
"title" : "Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes",
"pmid" : "16371630"
},
{
"timestamp" : "2017-12-03T22:35:08Z",
"briefDesignDescription" : "Rivaroxaban after VTE treatment",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700518",
"pageid" : 2927,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700518",
"trainingLevel" : "Resident",
"citation" : "Weitz JI, et al. \"Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism\". The New England Journal of Medicine. 2017. 376(13):1211-22.",
"subspecialties" : "Hematology",
"expansion" : "Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic Venous Thromboembolism",
"statusUsableDate" : "2017-07-01",
"briefResultsDescription" : "Rivaroxaban reduces recurrent VTE",
"published" : "2017-03-30",
"pageName" : "EINSTEIN CHOICE",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "EINSTEIN CHOICE",
"title" : "Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism",
"pmid" : "28316279"
},
{
"timestamp" : "2017-12-03T22:35:09Z",
"briefDesignDescription" : "Rivaroxaban vs. warfarin in PE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1113572",
"pageid" : 1519,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1113572",
"trainingLevel" : "Student",
"citation" : "Büller HR, et al. \"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism\". The New England Journal of Medicine. 2012. 366(14):1287-1297.",
"subspecialties" : "Hematology;Pulmonology",
"expansion" : "",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Rivaroxaban is noninferior to warfarin in PE treatment",
"published" : "2012-04-05",
"pageName" : "EINSTEIN-PE",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "EINSTEIN-PE",
"title" : "Oral rivaroxaban for the treatment of symptomatic pulmonary embolism",
"pmid" : "22449293"
},
{
"timestamp" : "2018-05-27T16:17:38Z",
"briefDesignDescription" : "Immunosuppression after kidney transplant",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067411",
"pageid" : 2324,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067411",
"trainingLevel" : "Resident",
"citation" : "Ekberg H, et al. \"Reduced exposure to calcineurin inhibitors in renal transplantation\". The New England Journal of Medicine. 2007. 357(25):2562-2575.",
"subspecialties" : "Nephrology",
"expansion" : "Efficacy Limiting Toxicity Elimination-Symphony",
"statusUsableDate" : "2015-02-01",
"briefResultsDescription" : "Daclizumab, mycophenolate, steroids, and tacrolimus beneficial",
"published" : "2007-12-20",
"pageName" : "ELITE-Symphony",
"diseases" : "Kidney Transplant",
"abbreviation" : "ELITE-Symphony",
"title" : "Reduced exposure to calcineurin inhibitors in renal transplantation",
"pmid" : "18094377"
},
{
"timestamp" : "2018-09-13T17:28:08Z",
"briefDesignDescription" : "Extended EKG monitoring after cryptogenic stroke",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1311376",
"pageid" : 2403,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1311376",
"trainingLevel" : "Resident",
"citation" : "Gladstone DJ, et al. \"Atrial Fibrillation in Patients with Cryptogenic Stroke\". The New England Journal of Medicine. 2014. 370(26):2467-2477.",
"subspecialties" : "Neurology;Cardiology",
"expansion" : "30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event",
"statusUsableDate" : "2018-09-13",
"briefResultsDescription" : "Extended EKG monitoring detects AF more frequently than 24-hour monitoring",
"published" : "2014-06-26",
"pageName" : "EMBRACE",
"diseases" : "Stroke;Atrial Fibrillation",
"abbreviation" : "EMBRACE",
"title" : "Atrial Fibrillation in Patients with Cryptogenic Stroke",
"pmid" : "24963566"
},
{
"timestamp" : "2021-07-28T13:09:44Z",
"briefDesignDescription" : "T-DM1 in metastatic breast cancer",
"fulltexturl" : "http://www.nejm.org/doi/abs/10.1056/NEJMoa1209124",
"pageid" : 1257,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1209124",
"trainingLevel" : "fellow",
"citation" : "Verma S, et al. \"Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer\". The New England Journal of Medicine. 2012. 367(19):1783-1791.",
"subspecialties" : "Oncology",
"expansion" : "Emtansine vs. Capecitabine+Lapatinib in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "T-DM1 prolongs PFS in metastatic breast cancer",
"published" : "2012-11-08",
"pageName" : "EMILIA",
"diseases" : "Breast Cancer",
"abbreviation" : "EMILIA",
"title" : "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer",
"pmid" : "23020162"
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{
"timestamp" : "2023-12-14T18:27:14Z",
"briefDesignDescription" : "Empagliflozin for CV outcomes in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1504720",
"pageid" : 2448,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1504720",
"trainingLevel" : "intern",
"citation" : "Zinman B, et al. \"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes\". The New England Journal of Medicine. 2015. 373(22):2117-28.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "",
"statusUsableDate" : "2015-10-01",
"briefResultsDescription" : "Empagliflozin reduces mortality compared to placebo in patients with type 2 diabetes",
"published" : "2015-09-17",
"pageName" : "EMPA-REG OUTCOME",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "EMPA-REG OUTCOME",
"title" : "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",
"pmid" : "26378978"
},
{
"timestamp" : "2022-10-13T18:59:03Z",
"briefDesignDescription" : "Empagliflozin in HFmrEF and HFpEF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2107038",
"pageid" : 4440,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Anker S, et al. \"Empagliflozin in Heart Failure with a Preserved Ejection Fraction\". New England Journal of Medicine. 2021. epub 2021-08-27:1-11.",
"subspecialties" : "Cardiology",
"expansion" : "Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction",
"statusUsableDate" : "2021-09-09",
"briefResultsDescription" : "Empagliflozin improved outcomes in HFpEF",
"published" : "2021-08-27",
"pageName" : "EMPEROR-Preserved",
"diseases" : "Heart Failure",
"abbreviation" : "EMPEROR-Preserved",
"title" : "Empagliflozin in Heart Failure with a Preserved Ejection Fraction",
"pmid" : "34449189"
},
{
"timestamp" : "2017-12-03T22:35:16Z",
"briefDesignDescription" : "Eplerenone in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009492",
"pageid" : 120,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009492",
"trainingLevel" : "Resident",
"citation" : "Zannad F, et al. \"Eplerenone in patients with systolic heart failure and mild symptoms\". The New England Journal of Medicine. 2011. 364(1):11-21.",
"subspecialties" : "Cardiology",
"expansion" : "Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure",
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Eplerenone reduces CV deaths and HF hospitalizations",
"published" : "2011-01-06",
"pageName" : "EMPHASIS-HF",
"diseases" : "Heart Failure",
"abbreviation" : "EMPHASIS-HF",
"title" : "Eplerenone in patients with systolic heart failure and mild symptoms",
"pmid" : "21073363"
},
{
"timestamp" : "2018-03-29T18:53:41Z",
"briefDesignDescription" : "Edoxaban vs. warfarin in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310907",
"pageid" : 2471,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310907",
"trainingLevel" : "resident",
"citation" : "Guigliano RP, et al. \"Edoxaban versus warfarin in patients with atrial fibrillation\". The New England Journal of Medicine. 2013. 369(22):2093-2104.",
"subspecialties" : "Cardiology",
"expansion" : "Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48",
"statusUsableDate" : "2017-02-01",
"briefResultsDescription" : "Edoxaban is noninferior to warfarin to prevent stroke or thromboembolism",
"published" : "2013-11-28",
"pageName" : "ENGAGE AF-TIMI 48",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "ENGAGE AF-TIMI 48",
"title" : "Edoxaban versus warfarin in patients with atrial fibrillation",
"pmid" : "24251359"
},
{
"timestamp" : "2019-04-18T17:47:16Z",
"briefDesignDescription" : "Aspirin vs. rivaroxaban for postoperative VTE prophylaxis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1712746",
"pageid" : 3552,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1712746",
"trainingLevel" : "Resident",
"citation" : "Anderson DR, et al. \"Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty\". The New England Journal of Medicine. 2018. 378(8):699-707.",
"subspecialties" : "Orthopedics;Hematology",
"expansion" : "Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II",
"statusUsableDate" : "2018-03-29",
"briefResultsDescription" : "Aspirin similar to rivaroxaban for prevention of VTE",
"published" : "2018-02-22",
"pageName" : "EPCAT II",
"diseases" : "Deep Vein Thrombosis;Hip Fracture;Meniscal Tear;Osteoarthritis;Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "EPCAT II",
"title" : "Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty",
"pmid" : "29466159"
},
{
"timestamp" : "2015-12-24T15:08:03Z",
"briefDesignDescription" : "Eplerenone post-MI with HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030207",
"pageid" : 16,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030207",
"trainingLevel" : "Resident",
"citation" : "Pitt B, et al. \"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction\". The New England Journal of Medicine. 2003. 348(14):1309-21.",
"subspecialties" : "Cardiology",
"expansion" : "Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit of eplerenone post MI with HFrEF",
"published" : "2003-04-03",
"pageName" : "EPHESUS",
"diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "EPHESUS",
"title" : "Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction",
"pmid" : "12668699"
},
{
"timestamp" : "2017-12-03T22:35:20Z",
"briefDesignDescription" : "PSA for prostate cancer screening",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810084",
"pageid" : 2796,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810084",
"trainingLevel" : "Intern",
"citation" : "Schröder FH, et al. \"Screening and Prostate-Cancer Mortality in a Randomized European Study\". The New England Journal of Medicine. 2009. 360(13):1320-1328.",
"subspecialties" : "Urology;Oncology;Preventive Medicine",
"expansion" : "European Randomized Study of Screening for Prostate Cancer",
"statusUsableDate" : "2016-07-01",
"briefResultsDescription" : "Decrease in prostate cancer mortality but increased risk of overdiagnosis and overtreatment",
"published" : "2009-07-09",
"pageName" : "ERSPC",
"diseases" : "Prostate Cancer",
"abbreviation" : "ERSPC",
"title" : "Screening and Prostate-Cancer Mortality in a Randomized European Study",
"pmid" : "19297566"
},
{
"timestamp" : "2017-12-03T22:35:21Z",
"briefDesignDescription" : "PA catheters in acute HF management",
"fulltexturl" : null,
"pageid" : 1407,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4994/JOC50108.pdf",
"trainingLevel" : "Resident",
"citation" : "Binanay C, et al. \"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness\". JAMA. 2005. 294(13):1625-1633.",
"subspecialties" : "Cardiology;Critical Care",
"expansion" : "Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Routine PA catheters no better than clinical assessment",
"published" : "2005-10-05",
"pageName" : "ESCAPE",
"diseases" : "Heart Failure",
"abbreviation" : "ESCAPE",
"title" : "Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness",
"pmid" : "16204662"
},
{
"timestamp" : "2017-12-03T22:35:22Z",
"briefDesignDescription" : "ASA+dipyridamole in secondary stroke prevention",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2806%2968734-5/fulltext",
"pageid" : 1726,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606687345.pdf",
"trainingLevel" : "Intern",
"citation" : "Halkes PH, et al. \"Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial\". The Lancet. 2006. 367(9523):1665-1673.",
"subspecialties" : "Neurology",
"expansion" : "European/Australasian Stroke Prevention in Reversible Ischaemia Trial",
"statusUsableDate" : "2013-11-01",
"briefResultsDescription" : "ASA+dipyridamole better than ASA for secondary stroke prevention",
"published" : "2006-05-20",
"pageName" : "ESPRIT",
"diseases" : "Stroke;Transient Ischemic Attack",
"abbreviation" : "ESPRIT",
"title" : "Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial",
"pmid" : "16714187"
},
{
"timestamp" : "2017-12-03T22:35:24Z",
"briefDesignDescription" : "LMWH vs. UFH in UA/NSTEMI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199708143370702",
"pageid" : 1443,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199708143370702",
"trainingLevel" : "Intern",
"citation" : "Cohen M, et al. \"A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease\". The New England Journal of Medicine. 1997. 337(7):447-452.",
"subspecialties" : "Cardiology",
"expansion" : "Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "LMWH reduces 14-day mortality, MI, or recurrent angina in UA/NSTEMI",
"published" : "1997-08-14",
"pageName" : "ESSENCE",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "ESSENCE",
"title" : "A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease",
"pmid" : "9250846"
},
{
"timestamp" : "2021-01-25T01:47:56Z",
"briefDesignDescription" : "Ticagrelor vs. clopidogrel in symptomatic PAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611688",
"pageid" : 2878,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611688",
"trainingLevel" : "Resident",
"citation" : "Hiatt WR et al. \"Ticagrelor versus clopidogrel in symptomatic peripheral artery disease\". New Engl J Med. 2017. 376(1):32-40.",
"subspecialties" : "Cardiology",
"expansion" : "Examining use of ticagrelor in peripheral artery disease",
"statusUsableDate" : "2017-01-01",
"briefResultsDescription" : "Ticagrelor not superior to clopidogrel in symptomatic PAD",
"published" : "2017-01-05",
"pageName" : "EUCLID (Ticagrelor)",
"diseases" : "Peripheral Vascular Disease",
"abbreviation" : "EUCLID",
"title" : "Ticagrelor versus clopidogrel in symptomatic peripheral artery disease",
"pmid" : "27959717"
},
{
"timestamp" : "2018-02-08T17:32:01Z",
"briefDesignDescription" : "Perindopril in patients with stable CAD",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14286-9/fulltext",
"pageid" : 2823,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14286-9.pdf",
"trainingLevel" : "intern",
"citation" : "Fox KM, et al. \"Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease\". The Lancet. 2003. 362(9386):782–788.",
"subspecialties" : "Cardiology",
"expansion" : "European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease",
"statusUsableDate" : "2018-02-08",
"briefResultsDescription" : "Perindopril reduces composite of CV mortality, MI, or cardiac arrest",
"published" : "2003-09-06",
"pageName" : "EUROPA",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "EUROPA",
"title" : "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease",
"pmid" : "13678872"
},
{
"timestamp" : "2017-12-03T22:35:34Z",
"briefDesignDescription" : "Dexamethasone in meningitis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021334",
"pageid" : 306,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021334",
"trainingLevel" : "Resident",
"citation" : "de Gans JD, et al. \"Dexamethasone in Adults with Bacterial Meningitis\". The New England Journal of Medicine. 2002. 347(20):1549-1556.",
"subspecialties" : "Infectious Disease;Neurology",
"expansion" : "European Dexamethasone Study",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "Dexamethasone reduces mortality in bacterial meningitis",
"published" : "2002-11-14",
"pageName" : "European Dexamethasone Study",
"diseases" : "Meningitis",
"abbreviation" : "EDS",
"title" : "Dexamethasone in Adults with Bacterial Meningitis",
"pmid" : "12432041"
},
{
"timestamp" : "2017-12-03T22:35:27Z",
"briefDesignDescription" : "Tolvaptan in acute HF in HFrEF",
"fulltexturl" : null,
"pageid" : 1345,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5131/joc70029_1319_1331.pdf",
"trainingLevel" : "Resident",
"citation" : "Konstam MA, et al. \"The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure\". The Journal of the American Medical Association. 2007. 297(12):1319-1331.",
"subspecialties" : "Cardiology",
"expansion" : "Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "No benefit from tolvaptan when given for 60 days after acute HF episode",
"published" : "2007-03-28",
"pageName" : "EVEREST-Outcomes",
"diseases" : "Heart Failure",
"abbreviation" : "EVEREST",
"title" : "The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure",
"pmid" : "17384437"
},
{
"timestamp" : "2017-12-03T22:35:28Z",
"briefDesignDescription" : "Cinacalcet in ESRD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205624",
"pageid" : 2426,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205624",
"trainingLevel" : "Resident",
"citation" : "Chertow GM, et al. \"Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis\". The New England Journal of Medicine. 2012. 367(26):2482-2494.",
"subspecialties" : "Nephrology",
"expansion" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
"statusUsableDate" : "2015-10-01",
"briefResultsDescription" : "Cinecalcet did not reduce CV events in ESRD",
"published" : "2012-12-27",
"pageName" : "EVOLVE",
"diseases" : "Chronic Kidney Disease;Cardiovascular Disease",
"abbreviation" : "EVOLVE",
"title" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
"pmid" : "23121374"
},
{
"timestamp" : "2017-12-03T22:35:29Z",
"briefDesignDescription" : "CABG vs. PCI in left main CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1610227",
"pageid" : 2868,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1610227",
"trainingLevel" : "Resident",
"citation" : "Stone GW, et al. \"Everolimus-eluting stents or bypass surgery for left main coronary artery disease\". The New England Journal of Medicine. 2016. 375(23):2223-35.",
"subspecialties" : "Cardiology",
"expansion" : "XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL)",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "PCI noninferior to CABG in left main CAD with low-intermediate anatomic complexity",
"published" : "2016-12-08",
"pageName" : "EXCEL",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "EXCEL",
"title" : "Everolimus-eluting stents or bypass surgery for left main coronary artery disease",
"pmid" : "27797291"
},
{
"timestamp" : "2017-12-03T22:35:31Z",
"briefDesignDescription" : "Omalizumab in severe allergic asthma",
"fulltexturl" : null,
"pageid" : 1434,
"pdfurl" : "http://annals.org/data/Journals/AIM/20231/0000605-201105030-00002.pdf",
"trainingLevel" : "Fellow",
"citation" : "Hanania NA, et al. \"Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial\". Annals of Internal Medicine. 2011. 154(9):573-582.",
"subspecialties" : "Allergy and Immunology;Pulmonology;Pediatrics",
"expansion" : "A Study of Omalizumab/Xolair in Subjects With Moderate to Severe Persistent Asthma",
"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Omalizumab reduces asthma exacerbations",
"published" : "2011-05-03",
"pageName" : "EXTRA",
"diseases" : "Asthma",
"abbreviation" : "EXTRA",
"title" : "Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial",
"pmid" : "21536936"
},
{
"timestamp" : "2015-11-07T23:16:22Z",
"briefDesignDescription" : "Fluid management in ARDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa062200",
"pageid" : 24,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa062200",
"trainingLevel" : "Resident",
"citation" : "Wiedemann HP, et al. \"Comparison of two fluid-management strategies in acute lung injury\". The New England Journal of Medicine. 2006. 354(24):2564-75.",
"subspecialties" : "Critical Care",
"expansion" : "Fluids and Catheters Treatment Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit of conservative fluid management in ALI/ARDS",
"published" : "2006-06-15",
"pageName" : "FACTT",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "FACTT",
"title" : "Comparison of two fluid-management strategies in acute lung injury",
"pmid" : "16714767"
},
{
"timestamp" : "2019-02-28T18:37:32Z",
"briefDesignDescription" : "Parenteral iron in HFrEF with iron deficiency",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa0908355",
"pageid" : 2691,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa0908355",
"trainingLevel" : "Intern",
"citation" : "Anker SD, et al. \"Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency\". The New England Journal of Medicine. 2009. 361(25):2436-48.",
"subspecialties" : "Cardiology;Hematology",
"expansion" : "IV Iron for Symptoms in Patients with HFrEF and Iron Deficiency",
"statusUsableDate" : "2019-03-01",
"briefResultsDescription" : "IV iron improves HFrEF symptoms in patients with HFrEF and iron deficiency",
"published" : "2009-12-17",
"pageName" : "FAIR-HF",
"diseases" : "Heart Failure;Iron Deficiency Anemia",
"abbreviation" : "FAIR-HF",
"title" : "Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency",
"pmid" : "19920054"
},
{
"timestamp" : "2018-01-03T20:13:15Z",
"briefDesignDescription" : "FFR-guided PCI in stable CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807611",
"pageid" : 998,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807611",
"trainingLevel" : "resident",
"citation" : "Tonino PAL, et al. \"Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention\". The New England Journal of Medicine. 2009. 360(3):213-224.",
"subspecialties" : "Cardiology",
"expansion" : "Fractional Flow Reserve versus Angiography for Multivessel Evaluation",
"statusUsableDate" : "2012-10-01",
"briefResultsDescription" : "FFR reduces composite of death, nonfatal MI, urgent revascularization",
"published" : "2009-01-15",
"pageName" : "FAME",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "FAME",
"title" : "Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention",
"pmid" : "19144937"
},
{
"timestamp" : "2018-07-05T13:05:28Z",
"briefDesignDescription" : "FFR-guided PCI vs. OMT in CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205361",
"pageid" : 1003,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205361",
"trainingLevel" : "Resident",
"citation" : "De Bruyne B, et al. \"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease\". The New England Journal of Medicine. 2012. 367(11):991-1001.",
"subspecialties" : "Cardiology",
"expansion" : "FFR vs. Angiographyfor Multivessel Evaluation 2",
"statusUsableDate" : "2012-11-01",
"briefResultsDescription" : "FFR-guided PCI reduces urgent revascularization",
"published" : "2012-09-13",
"pageName" : "FAME 2",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "FAME 2",
"title" : "Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease",
"pmid" : "22924638"
},
{
"timestamp" : "2017-12-03T22:35:38Z",
"briefDesignDescription" : "Fluid resuscitation in Sub-Saharan Africa",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1101549",
"pageid" : 1860,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1101549",
"trainingLevel" : "Resident",
"citation" : "Maitland K, et al. \"Mortality after fluid bolus in African children with severe infection\". The New England Journal of Medicine. 2011. 364(26):2483-2495.",
"subspecialties" : "Pediatrics;Critical Care",
"expansion" : "Fluid Expansion as Supportive Therapy",
"statusUsableDate" : "2014-11-01",
"briefResultsDescription" : "Albumin and saline increase mortality when compared to no fluids in this patient population",
"published" : "2011-06-30",
"pageName" : "FEAST",
"diseases" : "Shock",
"abbreviation" : "FEAST",
"title" : "Mortality after fluid bolus in African children with severe infection",
"pmid" : "21615299"
},
{
"timestamp" : "2013-10-07T20:50:13Z",
"briefDesignDescription" : "Fidaxomicin in C. difficile",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910812",
"pageid" : 255,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910812",
"trainingLevel" : "Resident",
"citation" : "Louie TJ, et al. \"Fidaxomicin versus Vancomycin for Clostridium difficile Infection\". The New England Journal of Medicine. 2011. 365(5):422-431.",
"subspecialties" : "Infectious Disease;Gastroenterology",
"expansion" : null,
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Fidaxomicin noninferior to vancomycin for cure, and resulted in 45% fewer recurrences",
"published" : "2011-02-03",
"pageName" : "Fidaxomicin in C. difficile Diarrhea",
"diseases" : "Clostridium difficile",
"abbreviation" : null,
"title" : "Fidaxomicin versus Vancomycin for Clostridium difficile Infection",
"pmid" : "21288078"
},
{
"timestamp" : "2017-12-03T22:35:39Z",
"briefDesignDescription" : "Cryoablation vs. RF ablation in pAF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602014",
"pageid" : 2795,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602014",
"trainingLevel" : "Resident",
"citation" : "Kuck K, et al. \"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation\". The New England Journal of Medicine. 2016. 374(23):2235-45.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2016-07-01",
"briefResultsDescription" : "Cryoablation equivalent to RF ablation in pAF",
"published" : "2016-06-09",
"pageName" : "FIRE AND ICE",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "FIRE AND ICE",
"title" : "Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation",
"pmid" : "27042964"
},
{
"timestamp" : "2017-12-03T22:35:41Z",
"briefDesignDescription" : "LABA+LAMA vs. LABA+ICS in COPD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1516385",
"pageid" : 2871,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1516385",
"trainingLevel" : "Resident",
"citation" : "Wedzicha JA, et al. \"Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD\". The New England Journal of Medicine. 2016. 374(23):2222-2234.",
"subspecialties" : "Pulmonology",
"expansion" : "Effect of Indacaterol Glycopyronium Vs. Fluticasone Salmeterol on COPD Exacerbations",
"statusUsableDate" : "2017-01-01",
"briefResultsDescription" : "LABA+LAMA reduces COPD exacerbations",
"published" : "2016-06-09",
"pageName" : "FLAME (COPD)",
"diseases" : "Emphysema;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease",
"abbreviation" : "FLAME COPD",
"title" : "Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD",
"pmid" : "27181606"
},
{
"timestamp" : "2018-10-08T21:47:35Z",
"briefDesignDescription" : "SSRI after CVA for motor recovery",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S1474-4422(10)70314-8",
"pageid" : 2370,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Chollet F, et al. \"Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial\". The Lancet Neurology. 2011. 10(2):123-130.",
"subspecialties" : "Neurology",
"expansion" : "Fluoxetine for Motor Recovery after Acute Ischaemic Stroke",
"statusUsableDate" : "2015-08-01",
"briefResultsDescription" : "Early fluoxetine improved motor outcomes post stroke",
"published" : "2011-02-01",
"pageName" : "FLAME (Stroke)",
"diseases" : "Stroke",
"abbreviation" : "FLAME",
"title" : "Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial",
"pmid" : "21216670"
},
{
"timestamp" : "2017-12-14T18:13:26Z",
"briefDesignDescription" : "Transfusion thresholds after hip surgery",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1012452",
"pageid" : 2985,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1012452",
"trainingLevel" : "Resident",
"citation" : "Carson JL, et al. \"Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery\". The New england Journal of Medicine. 2011. 365(26):2453-62.",
"subspecialties" : "Hematology;Surgery",
"expansion" : "Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair",
"statusUsableDate" : "2017-12-14",
"briefResultsDescription" : "Liberal transfusions no better than restrictive",
"published" : "2011-12-29",
"pageName" : "FOCUS",
"diseases" : "Hip Fracture;Anemia",
"abbreviation" : "FOCUS",
"title" : "Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery",
"pmid" : "22168590"
},
{
"timestamp" : "2020-11-05T18:42:16Z",
"briefDesignDescription" : "Evolocumab for CVD events if atherosclerotic disease",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1615664",
"pageid" : 2891,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1615664",
"trainingLevel" : "Resident",
"citation" : "Sabatine MS, et al. \"Evolocumab and clinical outcomes in patients with cardiovascular disease\". The New England Journal of Medicine. 2017. epub 2017-03-17:1-10.",
"subspecialties" : "Cardiology",
"expansion" : "Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk",
"statusUsableDate" : "2017-03-01",
"briefResultsDescription" : "Evolocumab reduces CV events in patients with atherosclerotic disease",
"published" : "2017-03-17",
"pageName" : "FOURIER",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "FOURIER",
"title" : "Evolocumab and clinical outcomes in patients with cardiovascular disease",
"pmid" : "28304224"
},
{
"timestamp" : "2017-12-03T22:35:45Z",
"briefDesignDescription" : "CABG vs. PCI for CAD in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211585",
"pageid" : 2314,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211585",
"trainingLevel" : "Resident",
"citation" : "Farkouh ME, et al. \"Strategies for multivessel revascularization in patients with diabetes\". The New England Journal of Medicine. 2012. 367(25):2375-2384.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease",
"statusUsableDate" : "2016-04-01",
"briefResultsDescription" : "CABG reduces death and revascularization rates but causes more strokes",
"published" : "2012-12-20",
"pageName" : "FREEDOM",
"diseases" : "Coronary Artery Disease;Diabetes Mellitus",
"abbreviation" : "FREEDOM",
"title" : "Strategies for multivessel revascularization in patients with diabetes",
"pmid" : "23121323"
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{
"timestamp" : "2021-06-01T13:47:49Z",
"briefDesignDescription" : "Early invasive strategy in UA/NSTEMI",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07349-3/fulltext",
"pageid" : 2451,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(99)07349-3.pdf",
"trainingLevel" : "Resident",
"citation" : "FRISC Investigators. \"Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study\". The Lancet. 1999. 354(9180):708-15.",
"subspecialties" : "Cardiology",
"expansion" : "FRagmin and Fast Revascularisation during InStability in Coronary artery disease-II",
"statusUsableDate" : "2015-11-01",
"briefResultsDescription" : "Fewer recurrent MIs with early invasive strategy in high-risk patients",
"published" : "1999-08-28",
"pageName" : "FRISC-II",
"diseases" : "Coronary Artery Disease;Myocardial Infarction;Acute Coronary Syndrome",
"abbreviation" : "FRISC-II",
"title" : "Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study",
"pmid" : "10475181"
},
{
"timestamp" : "2017-12-03T22:35:49Z",
"briefDesignDescription" : "Risk factors for GI bleeds in ICU patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199402103300601",
"pageid" : 391,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199402103300601",
"trainingLevel" : "Intern",
"citation" : "Cook DJ, et al. \"Risk factors for gastrointestinal bleeding in critically ill patients\". The New England Journal of Medicine. 1994. 330(6):337-381.",
"subspecialties" : "Critical Care;Gastroenterology",
"expansion" : null,
"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Greatest risk for GI bleed with coagulopathy and mechanical ventilation",
"published" : "1994-02-10",
"pageName" : "GI bleeding in ICU patients",
"diseases" : "Gastrointestinal Hemorrhage",
"abbreviation" : null,
"title" : "Risk factors for gastrointestinal bleeding in critically ill patients",
"pmid" : "8284001"
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{
"timestamp" : "2014-09-24T22:28:37Z",
"briefDesignDescription" : "Lisinopril in acute MI",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2894%2990232-1/abstract",
"pageid" : 258,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "GISSI-3 Group. \"Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction\". The Lancet. 1994. 343(8906):1115-22.",
"subspecialties" : "Cardiology",
"expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Lisinopril improves 6-week mortality",
"published" : "1994-05-07",
"pageName" : "GISSI-3",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "GISSI-3",
"title" : "Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction",
"pmid" : "7910229"
},
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"timestamp" : "2023-08-03T17:47:16Z",
"briefDesignDescription" : "PUFA in patients with heart failure",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61239-8/fulltext",
"pageid" : 2824,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)61239-8.pdf",
"trainingLevel" : "intern",
"citation" : "Tavazzi L, et al. \"Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure\". The Lancet. 2008. 372(9645):1223-1230.",
"subspecialties" : "Cardiology",
"expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione",
"statusUsableDate" : "2023-07-31",
"briefResultsDescription" : "PUFA reduces all-cause mortality and admission for CV disease",
"published" : "2008-10-04",
"pageName" : "GISSI-HF",
"diseases" : "Heart failure",
"abbreviation" : "GISSI-HF",
"title" : "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure",
"pmid" : "18757090"
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{
"timestamp" : "2017-12-03T22:35:51Z",
"briefDesignDescription" : "tPA in ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309023291001",
"pageid" : 2177,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309023291001",
"trainingLevel" : "Student",
"citation" : "Topol E, et al. \"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction\". The New England Journal of Medicine. 1993. 329(10):673-682.",
"subspecialties" : "Cardiology",
"expansion" : "Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries",
"statusUsableDate" : "2014-09-01",
"briefResultsDescription" : "tPA reduces mortality in ACS",
"published" : "1993-09-03",
"pageName" : "GUSTO",
"diseases" : "Myocardial Infarction;Acute Coronary Syndrome",
"abbreviation" : "GUSTO",
"title" : "An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction",
"pmid" : "8204123"
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{
"timestamp" : "2014-09-19T10:30:21Z",
"briefDesignDescription" : "Hypothermia for cardiac arrest",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/nejmoa012689",
"pageid" : 410,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa012689",
"trainingLevel" : "Resident",
"citation" : "Holzer M, et al. \"Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest\". The New England Journal of Medicine. 2002. 346(8):549-556.",
"subspecialties" : "Critical Care;Neurology;Cardiology",
"expansion" : "Hypothermia After Cardiac Arrest",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Hypothermia improves neurologic outcomes and reduces mortality",
"published" : "2002-02-21",
"pageName" : "HACA",
"diseases" : "Cardiac Arrest",
"abbreviation" : "HACA",
"title" : "Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest",
"pmid" : "11856793"
},
{
"timestamp" : "2017-12-03T22:35:53Z",
"briefDesignDescription" : "Continuous-flow LVAD in heart failure",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909938#t",
"pageid" : 2808,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909938",
"trainingLevel" : "Fellow",
"citation" : "Slaughter MS, et al. \"Advanced heart failure treated with continuous-flow left ventricular assist device\". The New England Journal of Medicine. 2009. 361(23):2241-2251.",
"subspecialties" : "Cardiology",
"expansion" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
"statusUsableDate" : "2016-09-01",
"briefResultsDescription" : "Continuous-flow LVAD improved survival free from stroke and device failure",
"published" : "2009-12-03",
"pageName" : "HEARTMATE II",
"diseases" : "Heart Failure",
"abbreviation" : "HEARTMATE II",
"title" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
"pmid" : "19920051"
},
{
"timestamp" : "2020-11-04T18:25:05Z",
"briefDesignDescription" : "Acetaminophen in febrile ICU patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1508375",
"pageid" : 2690,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1508375",
"trainingLevel" : "Intern",
"citation" : "Young P, et al. \"Acetaminophen for Fever in Critically Ill Patients with Suspected Infection\". The New England Journal of Medicine. 2015. 373(23):2215-2224.",
"subspecialties" : "Critical Care;Infectious Disease",
"expansion" : "Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit",
"statusUsableDate" : "2017-09-01",
"briefResultsDescription" : "Acetaminophen does not improves ICU outcomes",
"published" : "2015-12-03",
"pageName" : "HEAT",
"diseases" : "Sepsis;Fever",
"abbreviation" : "HEAT",
"title" : "Acetaminophen for Fever in Critically Ill Patients with Suspected Infection",
"pmid" : "26436473"
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{
"timestamp" : "2023-02-02T19:36:38Z",
"briefDesignDescription" : "Heparin vs. bivalirudin in PCI",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60924-7",
"pageid" : 2394,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Shahzad A, et al. \"Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.\". The Lancet. 2014. 384(9957):1849-1858.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2023-01-29",
"briefResultsDescription" : "Heparin better than bivalirudin for PCI",
"published" : "2014-11-22",
"pageName" : "HEAT-PPCI",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "HEAT-PPCI",
"title" : "Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.",
"pmid" : "25002178"
},
{
"timestamp" : "2018-10-25T17:06:10Z",
"briefDesignDescription" : "High dialysis dose and high-flux membrane in hemodialysis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021583",
"pageid" : 2771,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021583",
"trainingLevel" : "Fellow",
"citation" : "Rose EA, et al. \"Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis\". The New England Journal of Medicine. 2002. 347(25):2020-2019.",
"subspecialties" : "Nephrology",
"expansion" : "Hemodialysis",
"statusUsableDate" : "2018-03-15",
"briefResultsDescription" : "High dialysis dose and high-flux membrane did not reduce all-cause mortality",
"published" : "2002-12-19",
"pageName" : "HEMO",
"diseases" : "Chronic Kidney Disease",
"abbreviation" : "HEMO",
"title" : "Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis",
"pmid" : "12490682"
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{
"timestamp" : "2013-10-09T17:11:02Z",
"briefDesignDescription" : "Trastuzumab in breast cancer",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052306",
"pageid" : 440,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052306",
"trainingLevel" : "Resident",
"citation" : "Piccart-Gebhart MJ, et al. \"Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer\". The New England Journal of Medicine. 2005. 353(16):1659-72.",
"subspecialties" : "Oncology",
"expansion" : "Herceptin Adjuvant Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Trastuzumab improves survival",
"published" : "2005-10-20",
"pageName" : "HERA",
"diseases" : "Breast Cancer",
"abbreviation" : "HERA",
"title" : "Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer",
"pmid" : "16236737"
},
{
"timestamp" : "2020-10-29T17:37:34Z",
"briefDesignDescription" : "Edoxaban vs. LMWH in cancer VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711948",
"pageid" : 3509,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711948",
"trainingLevel" : "Resident",
"citation" : "Raskob GE, et al. \"Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism\". The New England Journal of Medicine. 2018. 378(7):615-624.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2018-02-01",
"briefResultsDescription" : "Edoxaban noninferior to dalteparin in cancer VTE",
"published" : "2018-02-15",
"pageName" : "Hokusai-VTE",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"abbreviation" : "",
"title" : "Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism",
"pmid" : "29231094"
},
{
"timestamp" : "2013-08-15T18:50:04Z",
"briefDesignDescription" : "Ramipril in patients with high CV risk",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200001203420301",
"pageid" : 1165,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200001203420301",
"trainingLevel" : "intern",
"citation" : "Yusuf S, et al. \"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients\". The New England Journal of Medicine. 2000. 342(3):145-153.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Heart Outcomes Prevention Evaluation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Ramipril reduces death, MI, and stroke",
"published" : "2000-01-20",
"pageName" : "HOPE",
"diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
"abbreviation" : "HOPE",
"title" : "Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients",
"pmid" : "10639539"
},
{
"timestamp" : "2020-12-31T20:42:03Z",
"briefDesignDescription" : "Voxelotor in sickle cell disease",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa1903212",
"pageid" : 4382,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903212",
"trainingLevel" : "resident",
"citation" : "Vichinsky E, et al. \"A phase 3 randomized trial of voxelotor in sickle cell disease\". The New England Journal of Medicine. 2019. 381(8):509-519.",
"subspecialties" : "Hematology",
"expansion" : "Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization",
"statusUsableDate" : "2020-12-10",
"briefResultsDescription" : "Voxelotor increases hemoglobin and reduces evidence of hemolysis",
"published" : "2019-08-08",
"pageName" : "HOPE (Sickle Cell Disease)",
"diseases" : "Sickle Cell Disease",
"abbreviation" : "HOPE",
"title" : "A phase 3 randomized trial of voxelotor in sickle cell disease",
"pmid" : "31199090"
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{
"timestamp" : "2019-09-20T14:01:16Z",
"briefDesignDescription" : "Statin, BP meds, both, or neither for CVD 1° prevention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1600177",
"pageid" : 2770,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1600177",
"trainingLevel" : "Resident",
"citation" : "Yusuf S, et al. \"Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease\". The New England Journal of Medicine. 2016. 374(21):2032-2343.",
"subspecialties" : "Cardiology",
"expansion" : "Heart Outcomes Prevention Evaluation-3",
"statusUsableDate" : "2019-09-19",
"briefResultsDescription" : "Statins lower events but BP meds don't.",
"published" : "2016-05-26",
"pageName" : "HOPE-3",
"diseases" : "Cardiovascular Disease",
"abbreviation" : "HOPE-3",
"title" : "Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease",
"pmid" : "27039945"
},
{
"timestamp" : "2021-09-09T17:34:24Z",
"briefDesignDescription" : "Zoledronate vs. placebo in osteoporosis",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa067312",
"pageid" : 2765,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa067312",
"trainingLevel" : "Resident",
"citation" : "Black DM, et al. \"Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis\". The New England Journal of Medicine. 2007. 356(18):1809-22.",
"subspecialties" : "Endocrinology;Preventive Medicine",
"expansion" : "Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial",
"statusUsableDate" : "2021-08-31",
"briefResultsDescription" : "Annual zoledronate reduces fracture risk in osteoporosis",
"published" : "2007-05-03",
"pageName" : "HORIZON-PFT",
"diseases" : "Osteoporosis",
"abbreviation" : "HORIZON-PFT",
"title" : "Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis",
"pmid" : "17476007"
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{
"timestamp" : "2021-04-09T09:10:14Z",
"briefDesignDescription" : "Duration of empiric antibiotics in ↑risk neutropenic fever",
"fulltexturl" : "https://doi.org/10.1016/S2352-3026(17)30211-9",
"pageid" : 4119,
"pdfurl" : null,
"trainingLevel" : "Fellow",
"citation" : "Aguilar-Guisado M, et al. \"Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial\". Lancet Haematology. 2017. 4(12):e573-e583.",
"subspecialties" : "Infectious Disease;Hematology",
"expansion" : null,
"statusUsableDate" : "2021-03-15",
"briefResultsDescription" : "Shorter courses of antibiotics led to fewer days of antibiotics without excess harm",
"published" : "2017-11-15",
"pageName" : "How Long",
"diseases" : "Febrile Neutropenia",
"abbreviation" : null,
"title" : "Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial",
"pmid" : "29153975"
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{
"timestamp" : "2020-02-06T19:36:49Z",
"briefDesignDescription" : "Simvastatin in high risk for CVD",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(02)09327-3",
"pageid" : 2696,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "Heart Protection Study Collaborative Group Writers. \"MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial\". The Lancet. 2002. 360(9326):7-22.",
"subspecialties" : "Cardiology",
"expansion" : "Heart Protection Study Statin Arm",
"statusUsableDate" : "2020-02-07",
"briefResultsDescription" : "Simvastatin reduces CVD events and death",
"published" : "2002-06-06",
"pageName" : "HPS Statin",
"diseases" : "Hyperlipidemia;Cardiovascular Disease",
"abbreviation" : "HPS",
"title" : "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial",
"pmid" : "12114036"
},
{
"timestamp" : "2017-12-03T22:35:56Z",
"briefDesignDescription" : "Niacin in atherosclerotic disease",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300955",
"pageid" : 2329,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300955",
"trainingLevel" : "Intern",
"citation" : "Landray MJ et al. \"Effects of extended-release niacin with laropiprant in high-risk patients\". The New England Journal of Medicine. 2014. 371(3):203-212.",
"subspecialties" : "Cardiology",
"expansion" : "Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events",
"statusUsableDate" : "2015-02-01",
"briefResultsDescription" : "Niacin is poorly tolerated, doesn't reduce major vascular events",
"published" : "2014-07-17",
"pageName" : "HPS2-THRIVE",
"diseases" : "Coronary Artery Disease;Peripheral Vascular Disease",
"abbreviation" : "HPS2-THRIVE",
"title" : "Effects of extended-release niacin with laropiprant in high-risk patients",
"pmid" : "25014686"
},
{
"timestamp" : "2017-12-03T22:35:58Z",
"briefDesignDescription" : "Early ART in HIV",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1105243",
"pageid" : 1010,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1105243",
"trainingLevel" : "Resident",
"citation" : "Cohen MS, et al. \"Prevention of HIV-1 Infection with Early Antiretroviral Therapy\". The New England Journal of Medicine. 2011. 365(6):493-505.",
"subspecialties" : "Infectious Disease",
"expansion" : "HIV Prevention Trials Network 052 Study",
"statusUsableDate" : "2012-10-01",
"briefResultsDescription" : "Reduced morbidity and HIV transmission",
"published" : "2011-08-11",
"pageName" : "HPTN 052",
"diseases" : "HIV",
"abbreviation" : "HPTN 052",
"title" : "Prevention of HIV-1 Infection with Early Antiretroviral Therapy",
"pmid" : "21767103"
},
{
"timestamp" : "2017-12-03T22:35:59Z",
"briefDesignDescription" : "High sensitivity troponin for acute chest pain",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109714017264",
"pageid" : 2343,
"pdfurl" : null,
"trainingLevel" : "Intern",
"citation" : "Bandstein N, et al. \"Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction\". Journal of the American College of Cardiology. 2014. 63(23):2569-2578.",
"subspecialties" : "Emergency Medicine;Cardiology",
"expansion" : null,
"statusUsableDate" : "2015-03-01",
"briefResultsDescription" : "HS troponin-T is associated with high NPV for MI at 30 days",
"published" : "2014-06-17",
"pageName" : "HS troponin-T to rule out MI",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : null,
"title" : "Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction",
"pmid" : "24694529"
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{
"timestamp" : "2017-12-03T22:36:04Z",
"briefDesignDescription" : "Perinatal vitamins to prevent neural tube defects",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199212243272602",
"pageid" : 2142,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199212243272602",
"trainingLevel" : "Student",
"citation" : "Czeizel AE and Dudas I. \"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation\". The New England Journal of Medicine. 1992. 327(26):1832-1835.",
"subspecialties" : "Obstetrics;Preventive Medicine",
"expansion" : null,
"statusUsableDate" : "2014-09-01",
"briefResultsDescription" : "Perinatal vitamins reduce neural tube defects",
"published" : "1992-12-24",
"pageName" : "Hungarian Prenatal Vitamin Trial",
"diseases" : "Neural Tube Defects",
"abbreviation" : null,
"title" : "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation",
"pmid" : "1307234"
},
{
"timestamp" : "2023-11-22T21:12:44Z",
"briefDesignDescription" : "Hydrocortisone, Vit C, and thiamine in sepsis",
"fulltexturl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext",
"pageid" : 2946,
"pdfurl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/pdf",
"trainingLevel" : "Resident",
"citation" : "Marik PE, et al. \"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study\". Chest. 2017. 151(6):1229-1238.",
"subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
"expansion" : "",
"statusUsableDate" : "2018-08-13",
"briefResultsDescription" : "Pilot study with impressive findings, low-quality data",
"published" : "2017-06-01",
"pageName" : "Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock",
"diseases" : "Sepsis;Shock",
"abbreviation" : "",
"title" : "Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study",
"pmid" : "27940189"
},
{
"timestamp" : "2018-02-08T17:14:46Z",
"briefDesignDescription" : "Hydrocortisone in severe sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMsa1410639",
"pageid" : 2860,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMsa1410639",
"trainingLevel" : "Resident",
"citation" : "Keh D, et al. \"Effect of hydrocortisone on development of shock among patients with severe sepsis\". Journal of the American Medical Association. 2016. 316(17):1775-1785.",
"subspecialties" : "Critical Care",
"expansion" : "",
"statusUsableDate" : "2016-11-01",
"briefResultsDescription" : "Hydrocortisone not superior to placebo in severe sepsis",
"published" : "2016-10-03",
"pageName" : "HYPRESS",
"diseases" : "Sepsis",
"abbreviation" : "HYPRESS",
"title" : "Effect of hydrocortisone on development of shock among patients with severe sepsis",
"pmid" : "27695824"
},
{
"timestamp" : "2018-01-11T18:14:28Z",
"briefDesignDescription" : "Elderly HTN treatment",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801369",
"pageid" : 2349,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801369",
"trainingLevel" : "Intern",
"citation" : "Beckett NS, et al. \"Treatment of hypertension in patients 80 years of age or older\". The New England Journal of Medicine. 2008. 358(18):1887-1898.",
"subspecialties" : "Nephrology;Cardiology;Geriatrics",
"expansion" : "Hypertension in the Very Elderly Trial",
"statusUsableDate" : "2015-04-01",
"briefResultsDescription" : "Trend towards reduction in stroke with treatment (P",
"published" : "2008-05-01",
"pageName" : "HYVET",
"diseases" : "Hypertension",
"abbreviation" : "HYVET",
"title" : "Treatment of hypertension in patients 80 years of age or older",
"pmid" : "18378519"
},
{
"timestamp" : "2017-09-24T13:54:35Z",
"briefDesignDescription" : "IABP in MI and cardiogenic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208410",
"pageid" : 1065,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208410",
"trainingLevel" : "Fellow",
"citation" : "Thiele H, et al. \"Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock\". The New England Journal of Medicine. 2012. 367(14):1287-1296.",
"subspecialties" : "Cardiology;Critical Care",
"expansion" : "Intraaortic Balloon Pump in Cardiogenic Shock II",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "IABP did not reduce mortality at 30 days",
"published" : "2012-10-10",
"pageName" : "IABP-SHOCK II",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
"abbreviation" : "IABP-SHOCK II",
"title" : "Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock",
"pmid" : "22920912"
},
{
"timestamp" : "2019-05-23T17:29:10Z",
"briefDesignDescription" : "Adjuvant cisplatin in resected NSCLC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa031644",
"pageid" : 2503,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa031644",
"trainingLevel" : "Fellow",
"citation" : "Arriagada R, et al. \"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer\". The New England Journal of Medicine. 2004. 350(4):351-360.",
"subspecialties" : "Oncology",
"expansion" : "International Adjuvant Lung Cancer Trial",
"statusUsableDate" : "2019-05-23",
"briefResultsDescription" : "Adjuvant cisplatin improves 5-year OS in resected NSCLC",
"published" : "2004-01-22",
"pageName" : "IALT",
"diseases" : "Lung Cancer",
"abbreviation" : "IALT",
"title" : "Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer",
"pmid" : "14736927"
},
{
"timestamp" : "2021-11-04T17:33:05Z",
"briefDesignDescription" : "Second-line ibrutinib in WM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501548",
"pageid" : 2660,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501548",
"trainingLevel" : "Fellow",
"citation" : "Treon SP, et al. \"Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia\". The New England Journal of Medicine. 2015. 372(15):1430-1440.",
"subspecialties" : "Hematology",
"expansion" : null,
"statusUsableDate" : "2015-12-01",
"briefResultsDescription" : "Ibrutinib is safe and effective in previously treated WM",
"published" : "2015-04-09",
"pageName" : "Ibrutinib in Waldenstrom macroglobulinemia",
"diseases" : "Lymphoma;Waldenström Macroglobulinemia",
"abbreviation" : null,
"title" : "Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia",
"pmid" : "25853747"
},
{
"timestamp" : "2020-02-10T07:03:58Z",
"briefDesignDescription" : "Ibrutinib-rituximab vs. FCR in untreated CLL",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1817073",
"pageid" : 4175,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817073",
"trainingLevel" : "Fellow",
"citation" : "Shanafelt TD, et al. \"Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia\". The New England Journal of Medicine. 2019. 381(5):432-43.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2020-02-09",
"briefResultsDescription" : "IR improved survival over FCR in untreated CLL",
"published" : "2019-08-01",
"pageName" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
"diseases" : "Chronic Lymphocytic Leukemia;Small Lymphocytic Lymphoma",
"abbreviation" : "E1912",
"title" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
"pmid" : "31365801"
},
{
"timestamp" : "2018-10-16T05:02:38Z",
"briefDesignDescription" : "Colchicine in the first episode of acute pericarditis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208536",
"pageid" : 1729,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208536",
"trainingLevel" : "Intern",
"citation" : "Imazio M, et al. \"A Randomized Trial of Colchicine for Acute Pericarditis\". The New England Journal of Medicine. 2013. 369(16):1522-1528.",
"subspecialties" : "Cardiology",
"expansion" : "Evaluation of additive benefit of colchicine to conventional therapy in acute pericarditis",
"statusUsableDate" : "2014-01-01",
"briefResultsDescription" : "Colchicine reduces incessant or recurrent acute pericarditis when used in first episode",
"published" : "2013-10-17",
"pageName" : "ICAP",
"diseases" : "Pericarditis",
"abbreviation" : "ICAP",
"title" : "A Randomized Trial of Colchicine for Acute Pericarditis",
"pmid" : "23992557"
},
{
"timestamp" : "2017-12-03T22:36:07Z",
"briefDesignDescription" : "Early vs. late dialysis in CKD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000552",
"pageid" : 1020,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000552",
"trainingLevel" : "Resident",
"citation" : "Cooper BA, et al. \"A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis\". The New England Journal of Medicine. 2010. 363(7):609-619.",
"subspecialties" : "Nephrology",
"expansion" : "Initiating Dialysis Early and Late",
"statusUsableDate" : "2012-10-01",
"briefResultsDescription" : "No difference in survival or clinical outcomes",
"published" : "2010-08-12",
"pageName" : "IDEAL",
"diseases" : "Chronic Kidney Disease",
"abbreviation" : "IDEAL",
"title" : "A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis",
"pmid" : "20581422"
},
{
"timestamp" : "2019-03-27T18:27:05Z",
"briefDesignDescription" : "Early vs. delayed RRT in septic shock",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1803213",
"pageid" : 3746,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1803213",
"trainingLevel" : "Resident",
"citation" : "Barbar SD, et al. \"Timing of renal-replacement therapy in patients with acute kidney injury and sepsis\". The New England Journal of Medicine. 2018. 379(15):1431-1442.",
"subspecialties" : "Critical Care;Nephrology",
"expansion" : "Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit",
"statusUsableDate" : "2019-03-27",
"briefResultsDescription" : "No benefit from early initiated RRT in septic shock",
"published" : "2018-10-11",
"pageName" : "IDEAL-ICU",
"diseases" : "Acute Kidney Injury;Septic Shock",
"abbreviation" : "IDEAL-ICU",
"title" : "Timing of renal-replacement therapy in patients with acute kidney injury and sepsis",
"pmid" : "30304656"
},
{
"timestamp" : "2017-12-03T22:36:08Z",
"briefDesignDescription" : "ARBs in diabetic nephropathy",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011303",
"pageid" : 2670,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011303",
"trainingLevel" : "Resident",
"citation" : "Lewis EJ, et al. \"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes\". The New England Journal of Medicine. 2001. 345(12):851-860.",
"subspecialties" : "Nephrology;Endocrinology",
"expansion" : "Irbesartan Diabetic Nephropathy Trial",
"statusUsableDate" : "2016-01-01",
"briefResultsDescription" : "ARBs prevent progression of T2DM nephropathy",
"published" : "2001-09-20",
"pageName" : "IDNT",
"diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
"abbreviation" : "IDNT",
"title" : "Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes",
"pmid" : "11565517"
},
{
"timestamp" : "2017-12-03T22:36:10Z",
"briefDesignDescription" : "iFR vs. FFR for PCI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1616540",
"pageid" : 2926,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1616540",
"trainingLevel" : "Resident",
"citation" : "Gotberg M, et al. \"Spontaneous wave-free ratio versus fractional flow reserve to guide PCI\". The New England Journal of Medicine. 2017. 376(19):1813-1823.",
"subspecialties" : "Cardiology",
"expansion" : "Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome",
"statusUsableDate" : "2017-05-01",
"briefResultsDescription" : "iFR noninferior to FFR for PCI",
"published" : "2017-05-11",
"pageName" : "IFR-SWEDEHEART",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "iFR-SWEDEHEART",
"title" : "Spontaneous wave-free ratio versus fractional flow reserve to guide PCI",
"pmid" : "28317438"
},
{
"timestamp" : "2017-12-14T19:46:19Z",
"briefDesignDescription" : "Ezetimibe+simvastatin after ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1410489",
"pageid" : 2369,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489",
"trainingLevel" : "Intern",
"citation" : "Cannon CP, et al. \"Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes\". The New England Journal of Medicine. 2015. 375(25):2387-2397.",
"subspecialties" : "Cardiology",
"expansion" : "IMProved Reduction of Outcomes: Vytorin Efficacy International Trial",
"statusUsableDate" : "2015-06-01",
"briefResultsDescription" : "Ezetimibe improves CV outcomes when added to statin",
"published" : "2015-06-18",
"pageName" : "IMPROVE-IT",
"diseases" : "Hyperlipidemia;Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "IMPROVE-IT",
"title" : "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes",
"pmid" : "26039521"
},
{
"timestamp" : "2018-03-30T14:11:39Z",
"briefDesignDescription" : "Nintedanib in IPF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402584",
"pageid" : 2934,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402584",
"trainingLevel" : "Resident",
"citation" : "Richeldi L, et al. \"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis\". The New England Journal of Medicine. 2014. 370(22):2071-2082.",
"subspecialties" : "Pulmonology",
"expansion" : "",
"statusUsableDate" : "2018-03-30",
"briefResultsDescription" : "Nintedanib slows progression of IPF",
"published" : "2014-05-29",
"pageName" : "INPULSIS Trials",
"diseases" : "Idiopathic Pulmonary Fibrosis",
"abbreviation" : "INPULSIS I and II",
"title" : "Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis",
"pmid" : "24836310"
},
{
"timestamp" : "2017-12-03T22:36:12Z",
"briefDesignDescription" : "Early vs. delayed ART in HIV",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506816",
"pageid" : 2468,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506816",
"trainingLevel" : "Student",
"citation" : "INSIGHT START Writers. \"Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection\". The New England Journal of Medicine. 2015. 373(9):795-807.",
"subspecialties" : "Infectious Disease",
"expansion" : null,
"statusUsableDate" : "2016-01-01",
"briefResultsDescription" : "Less complications with early ART",
"published" : "2015-08-27",
"pageName" : "INSIGHT START",
"diseases" : "HIV",
"abbreviation" : "START",
"title" : "Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection",
"pmid" : "26192873"
},
{
"timestamp" : "2017-12-03T22:36:14Z",
"briefDesignDescription" : "ART in primary HIV prevention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011205",
"pageid" : 1100,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011205",
"trainingLevel" : "intern",
"citation" : "Grant RM, et al. \"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men\". The New England Journal of Medicine. 2010. 363(27):2587-2599.",
"subspecialties" : "Infectious Disease;Preventive Medicine",
"expansion" : "Iniciativa Profilaxis Pre Exposicion (\"Preexposure Prophylaxis Initiative\")",
"statusUsableDate" : "2013-02-01",
"briefResultsDescription" : "ART reduces tranmission of HIV among MSM",
"published" : "2010-12-30",
"pageName" : "IPrEx",
"diseases" : "HIV",
"abbreviation" : "iPrEx",
"title" : "Preexposure chemoprophylaxis for HIV prevention in men who have sex with men",
"pmid" : "21091279"
},
{
"timestamp" : "2017-12-03T22:36:15Z",
"briefDesignDescription" : "Imatinib vs. IFNα/cytarabine in CML",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa022457",
"pageid" : 1076,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa022457",
"trainingLevel" : "Student",
"citation" : "O'Brien SG, et al. \"Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia\". The New England Journal of Medicine. 2003. 384(11):994-1004.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "International Randomized Study of Interferon and STI571",
"statusUsableDate" : "2012-11-01",
"briefResultsDescription" : "Imatinib delays disease progression",
"published" : "2003-03-13",
"pageName" : "IRIS",
"diseases" : "Chronic Myeloid Leukemia;Myeloproliferative Neoplasms",
"abbreviation" : "IRIS",
"title" : "Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia",
"pmid" : "12637609"
},
{
"timestamp" : "2017-12-03T22:36:17Z",
"briefDesignDescription" : "Oral iron vs. placebo in HFrEF and iron deficiency",
"fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
"pageid" : 2941,
"pdfurl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
"trainingLevel" : "Resident",
"citation" : "Lewis GD, et al. \"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency\". JAMA. 2017. 317(19):1958-66.",
"subspecialties" : "Cardiology",
"expansion" : "Iron Repletion Effects on Oxygen Uptake in Heart Failure",
"statusUsableDate" : "2017-07-01",
"briefResultsDescription" : "Oral iron not superior to placebo in HFrEF",
"published" : "2017-07-09",
"pageName" : "IRONOUT-HF",
"diseases" : "Heart Failure",
"abbreviation" : "IRONOUT-HF",
"title" : "Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency",
"pmid" : "28510680"
},
{
"timestamp" : "2019-10-17T17:39:50Z",
"briefDesignDescription" : "Ticagrelor vs. prasugrel in ACS",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1908973",
"pageid" : 4100,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1908973",
"trainingLevel" : "Resident",
"citation" : "Schupke S et al. \"Ticagrelor or prasugrel in patients with acute coronary syndromes\". New Engl J Med. 2019. 1-11.",
"subspecialties" : "Cardiology",
"expansion" : "Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5 Trial",
"statusUsableDate" : "2019-10-17",
"briefResultsDescription" : "Prasugrel superior to ticagrelor in acute coronary syndromes",
"published" : "2019-09-01",
"pageName" : "ISAR-REACT 5",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "ISAR-REACT 5",
"title" : "Ticagrelor or prasugrel in patients with acute coronary syndromes",
"pmid" : "31475799"
},
{
"timestamp" : "2021-01-30T20:57:06Z",
"briefDesignDescription" : "Triple therapy for 6w vs. 6m after DES",
"fulltexturl" : "http://content.onlinejacc.org/article.aspx?articleID",
"pageid" : 2812,
"pdfurl" : "https://www.jacc.org/doi/pdf/10.1016/j.jacc.2015.02.050",
"trainingLevel" : "Intern",
"citation" : "Fiedler KA et al. \"Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation\". J Am Coll Cardiol. 2015. 65(16):1619-30.",
"subspecialties" : "Cardiology",
"expansion" : "Triple therapy in Patients who Require Oral Anticoagulation After Drug-Eluting Stent Implantation",
"statusUsableDate" : "2016-10-01",
"briefResultsDescription" : "Triple therapy for 6 weeks not superior to 6 months in regards to net clinical outcome",
"published" : "2015-04-28",
"pageName" : "ISAR-TRIPLE",
"diseases" : "Coronary Artery Disease;Atrial Fibrillation",
"abbreviation" : "ISAR-TRIPLE",
"title" : "Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation",
"pmid" : "25908066"
},
{
"timestamp" : "2021-04-07T17:13:36Z",
"briefDesignDescription" : "PCI/CABG vs. medical therapy in stable CAD",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1915922",
"pageid" : 4153,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915922",
"trainingLevel" : "Resident",
"citation" : "Maron DJ, et al. \"Initial Invasive or Conservative Strategy for Stable Coronary Disease\". The New England Journal of Medicine. 2020. 382(15):1395-1407.",
"subspecialties" : "Cardiology",
"expansion" : "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches",
"statusUsableDate" : "2021-01-28",
"briefResultsDescription" : "No difference between PCI/CABG and medical therapy in stable CAD with moderate-severe ischemia",
"published" : "2020-04-09",
"pageName" : "ISCHEMIA",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "ISCHEMIA",
"title" : "Initial Invasive or Conservative Strategy for Stable Coronary Disease",
"pmid" : "32227755"
},
{
"timestamp" : "2017-12-20T19:04:02Z",
"briefDesignDescription" : "Aspirin ± streptokinase in acute MI",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(88)92833-4/abstract",
"pageid" : 133,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "ISIS-2 Collaborative Group. \"Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17187 Cases of Suspected Acute Myocardial Infarction\". The Lancet. 1988. 332(8607):349-360.",
"subspecialties" : "Cardiology",
"expansion" : "Second International Study of Infarct Survival",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit of aspirin within 24 hours of acute MI",
"published" : "1988-08-13",
"pageName" : "ISIS-2",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "ISIS-2",
"title" : "Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17187 Cases of Suspected Acute Myocardial Infarction",
"pmid" : "2899772"
},
{
"timestamp" : "2016-03-07T04:46:48Z",
"briefDesignDescription" : "Aspirin in acute ischemic stroke",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(97)04011-7/fulltext",
"pageid" : 132,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673697040117.pdf",
"trainingLevel" : "Intern",
"citation" : "IST Collaborative Group. \"The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke\". The Lancet. 1997. 349(9065):1569-1581.",
"subspecialties" : "Neurology",
"expansion" : "International Stroke Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit with aspirin",
"published" : "1997-05-31",
"pageName" : "IST",
"diseases" : "Stroke",
"abbreviation" : "IST",
"title" : "The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke",
"pmid" : "9174558"
},
{
"timestamp" : "2017-12-03T22:36:21Z",
"briefDesignDescription" : "Rosuvastatin for primary CV prevention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807646",
"pageid" : 445,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807646",
"trainingLevel" : "resident",
"citation" : "Ridker PM, et al. \"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein\". The New England Journal of Medicine. 2008. 359(21):2195-2207.",
"subspecialties" : "Cardiology;Preventive Medicine",
"expansion" : "Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin",
"statusUsableDate" : "2012-06-01",
"briefResultsDescription" : "Rosuvastatin delays major CV events",
"published" : "2008-11-20",
"pageName" : "JUPITER",
"diseases" : "Hyperlipidemia;Coronary Artery Disease;Stroke;Transient Ischemic Attack",
"abbreviation" : "JUPITER",
"title" : "Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein",
"pmid" : "18997196"
},
{
"timestamp" : "2017-12-03T22:36:23Z",
"briefDesignDescription" : "Pembrolizumab vs. chemotherapy in NSCLC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1606774",
"pageid" : 2846,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1606774",
"trainingLevel" : "Resident",
"citation" : "Reck M, et al. \"Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer\". The New England Journal of Medicine. 2016. 375(19):1824-1833.",
"subspecialties" : "Oncology",
"expansion" : "",
"statusUsableDate" : "2016-11-01",
"briefResultsDescription" : "Pembrolizumab improves survival in advanced NSCLC over chemotherapy",
"published" : "2016-11-10",
"pageName" : "KEYNOTE-024",
"diseases" : "Lung Cancer",
"abbreviation" : "KEYNOTE-024",
"title" : "Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer",
"pmid" : "27718847"
},
{
"timestamp" : "2023-11-22T21:21:50Z",
"briefDesignDescription" : "Liraglutide and CVD endpoints in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603827",
"pageid" : 2803,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603827",
"trainingLevel" : "Resident",
"citation" : "Marso SP, et al. \"Liraglutide and cardiovascular outcomes in type 2 diabetes\". The New England Journal of Medicine. 2016. 375(4):311-322.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results",
"statusUsableDate" : "2016-09-01",
"briefResultsDescription" : "Liraglutide reduces CV mortality in T2DM",
"published" : "2016-06-28",
"pageName" : "LEADER",
"diseases" : "Diabetes Mellitus;Cardiovascular Disease",
"abbreviation" : "LEADER",
"title" : "Liraglutide and cardiovascular outcomes in type 2 diabetes",
"pmid" : "27295427"
},
{
"timestamp" : "2018-10-25T17:05:24Z",
"briefDesignDescription" : "Lenalidomide/dexamethasone in smoldering MM",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1300439",
"pageid" : 3706,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1300439",
"trainingLevel" : "Fellow",
"citation" : "Mateos MV, et al. \"Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma\". The New England Journal of Medicine. 2013. 369(5):438-47.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2018-10-25",
"briefResultsDescription" : "In flawed trial, LenDex improved OS compared to observation",
"published" : "2013-08-01",
"pageName" : "LenDex in High-Risk Smoldering Myeloma",
"diseases" : "Multiple Myeloma",
"abbreviation" : "",
"title" : "Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma",
"pmid" : "23902483"
},
{
"timestamp" : "2017-12-03T22:36:26Z",
"briefDesignDescription" : "Epidural steroids in spinal stenosis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313265",
"pageid" : 1883,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313265",
"trainingLevel" : "Resident",
"citation" : "Friedly JL, et al. \"A randomized trial of epidural glucocorticoid injections for spinal stenosis\". The New England Journal of Medicine. 2014. 371(1):11-21.",
"subspecialties" : "Pain Medicine;Physical Medicine and Rehabilitation;Radiology",
"expansion" : "Lumbar Epidural Steroid Injections for Spinal Stenosis",
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Epidural steroids don't improve pain or disability at six weeks",
"published" : "2014-07-03",
"pageName" : "LESS",
"diseases" : "Spinal Stenosis",
"abbreviation" : "LESS",
"title" : "A randomized trial of epidural glucocorticoid injections for spinal stenosis",
"pmid" : "24988555"
},
{
"timestamp" : "2017-01-19T20:18:41Z",
"briefDesignDescription" : "Intensive glycemic therapy in the surgical ICU",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011300",
"pageid" : 139,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011300",
"trainingLevel" : "Resident",
"citation" : "Van den Berghe G, et al. \"Intensive Insulin Therapy in Critically Ill Patients\". The New England Journal of Medicine. 2001. 345(19):1359-1367.",
"subspecialties" : "Critical Care;Endocrinology",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Intensive glycemic control reduces mortality",
"published" : "2001-11-08",
"pageName" : "Leuven Surgical Trial",
"diseases" : "Stress Hyperglycemia",
"abbreviation" : "Leuven Surgical Trial",
"title" : "Intensive Insulin Therapy in Critically Ill Patients",
"pmid" : "11794168"
},
{
"timestamp" : "2024-04-02T17:35:36Z",
"briefDesignDescription" : "ARB vs. B-blocker in HTN with LVH",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08089-3/abstract",
"pageid" : 2439,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(02)08089-3.pdf",
"trainingLevel" : "Student",
"citation" : "Dahlof B, et al. \"Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)\". The Lancet. 2002. 359:995-1003.",
"subspecialties" : "Nephrology",
"expansion" : "Cardiovvascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol",
"statusUsableDate" : "2024-03-29",
"briefResultsDescription" : "Losartan lowers stroke, MI, or CVD mortality vs. atenolol in HTN with LVH",
"published" : "2002-03-23",
"pageName" : "LIFE",
"diseases" : "Hypertension;Cardiovascular Disease;Stroke",
"abbreviation" : "LIFE",
"title" : "Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)",
"pmid" : "11937178"
},
{
"timestamp" : "2017-12-03T22:36:27Z",
"briefDesignDescription" : "ATRA-ATO vs. ATRA-chemotherapy in APL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300874",
"pageid" : 2285,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300874",
"trainingLevel" : "Fellow",
"citation" : "Lo-Coco F, et al. \"Retinoic acid and arsenic trioxide for acute promyelocytic leukemia\". The New England Journal of Medicine. 2013. 369(2):111-21.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "",
"statusUsableDate" : "2014-12-01",
"briefResultsDescription" : "ATRA-ATO is noninferior, possibly superior to ATRA-chemotherapy in APL",
"published" : "2013-07-11",
"pageName" : "Lo-Coco 2013",
"diseases" : "Leukemia",
"abbreviation" : "",
"title" : "Retinoic acid and arsenic trioxide for acute promyelocytic leukemia",
"pmid" : "23841729"
},
{
"timestamp" : "2021-02-18T20:36:25Z",
"briefDesignDescription" : "Colchicine for stable CAD",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109712054782",
"pageid" : 1583,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Nidorf SM, et al. \"Low-dose colchicine for secondary prevention of cardiovascular disease\". Journal of the American College of Cardiology. 2013. 61(4):404-410.",
"subspecialties" : "Cardiology",
"expansion" : "Low-Dose Colchicine",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Colcicine may reduce complications in stable CAD",
"published" : "2013-01-29",
"pageName" : "LoDoCo",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "LoDoCo",
"title" : "Low-dose colchicine for secondary prevention of cardiovascular disease",
"pmid" : "23265346"
},
{
"timestamp" : "2021-02-18T20:38:17Z",
"briefDesignDescription" : "Colchicine in stable CAD",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2021372",
"pageid" : 4359,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021372",
"trainingLevel" : "Resident",
"citation" : "Nidorf SM, et al. \"Colchicine in patients with chronic coronary disease\". The New England Journal of Medicine. 2020. 383(19):1838-1847.",
"subspecialties" : "Cardiology",
"expansion" : "Low Dose Colchicine 2",
"statusUsableDate" : "2021-02-18",
"briefResultsDescription" : "Colchicine with fewer CV events",
"published" : "2020-11-05",
"pageName" : "LoDoCo2",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "LoDoCo2",
"title" : "Colchicine in patients with chronic coronary disease",
"pmid" : "32865380"
},
{
"timestamp" : "2017-12-03T22:37:21Z",
"briefDesignDescription" : "Weight loss and exercise in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212914",
"pageid" : 1546,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212914",
"trainingLevel" : "Intern",
"citation" : "Wing RR, et al. \"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes\". The New England Journal of Medicine. 2013. 369(2):145-154.",
"subspecialties" : "Endocrinology;Cardiology",
"expansion" : "Look Action for HEAlth in Diabetes",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "No reduction of CVD with weight loss and exercise in T2DM",
"published" : "2013-07-11",
"pageName" : "Look AHEAD",
"diseases" : "Diabetes Mellitus;Cardiovascular Disease",
"abbreviation" : "Look AHEAD",
"title" : "Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes",
"pmid" : "23796131"
},
{
"timestamp" : "2023-11-09T19:05:49Z",
"briefDesignDescription" : "Vitamin C in sepsis",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2200644",
"pageid" : 5147,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2200644",
"trainingLevel" : "Resident",
"citation" : "Lamontagne, F, et al. \"Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit\". New England Journal of Medicine. 2022. 386(25):2387-2398.",
"subspecialties" : "Critical Care;Infectious Disease",
"expansion" : "Lessening Organ Dysfunction with Vitamin C",
"statusUsableDate" : "2023-10-28",
"briefResultsDescription" : "Vitamin C associated with greater risk of poor ICU outcomes",
"published" : "2022-06-23",
"pageName" : "LOVIT",
"diseases" : "Septic Shock",
"abbreviation" : "LOVIT",
"title" : "Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit",
"pmid" : "35704292"
},
{
"timestamp" : "2017-12-03T22:37:23Z",
"briefDesignDescription" : "CRT in HFrEF with QRS ≥130 msec and mild symptoms",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906431",
"pageid" : 1780,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906431",
"trainingLevel" : "Resident",
"citation" : "Moss AJ, et al. \"Cardiac-resynchronization therapy for the prevention of heart-failure events\". The New England Journal of Medicine. 2009. 361(14):1329-1338.",
"subspecialties" : "Cardiology",
"expansion" : "Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy",
"statusUsableDate" : "2014-04-01",
"briefResultsDescription" : "CRT reduces mortality or HF complications in mildly symptomatic HFrEF with prolonged QRS",
"published" : "2009-10-01",
"pageName" : "MADIT-CRT",
"diseases" : "Heart Failure",
"abbreviation" : "MADIT-CRT",
"title" : "Cardiac-resynchronization therapy for the prevention of heart-failure events",
"pmid" : "19723701"
},
{
"timestamp" : "2019-03-07T17:25:42Z",
"briefDesignDescription" : "ICD post-MI with HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013474",
"pageid" : 385,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013474",
"trainingLevel" : "Resident",
"citation" : "Moss AJ, et al. \"Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction\". The New England Journal of Medicine. 2002. 346(12):877-883.",
"subspecialties" : "Cardiology",
"expansion" : "Multicenter Automatic Defibrillator Implantation Trial II",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "ICD improves survival in post-MI patients with LVEF≤30%",
"published" : "2002-03-21",
"pageName" : "MADIT-II",
"diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "MADIT-II",
"title" : "Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction",
"pmid" : "11907286"
},
{
"timestamp" : "2017-12-03T22:37:25Z",
"briefDesignDescription" : "Rivaroxaban vs. LMWH for VTE prophylaxis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1111096",
"pageid" : 1272,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1111096",
"trainingLevel" : "Resident",
"citation" : "Cohen AT, et al. \"Rivaroxaban for thromboprophylaxis in acutely ill medical patients\". The New England Journal of Medicine. 2013. 368(6):513-523.",
"subspecialties" : "Hematology",
"expansion" : "Multicenter, Randomized, Parallel Group Efficacy and Safety Study for the Prevention of Venous Thromboembolism in Hospitalized Acutely Ill Medical Patients Comparing Rivaroxaban with Enoxaparin",
"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Rivaroxaban similar to LMWH for prophylaxis, caused more bleeding",
"published" : "2013-02-07",
"pageName" : "MAGELLAN",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "MAGELLAN",
"title" : "Rivaroxaban for thromboprophylaxis in acutely ill medical patients",
"pmid" : "23388003"
},
{
"timestamp" : "2018-10-08T21:48:25Z",
"briefDesignDescription" : "Rivaroxaban VTE ppx after medical admission",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1805090",
"pageid" : 3699,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1805090",
"trainingLevel" : "Resident",
"citation" : "Spyropoulos AC, et al. \"Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness\". The New England Journal of Medicine. 2018. e-published 2018-08-26:1-10.",
"subspecialties" : "Hematology;Cardiology",
"expansion" : "Medically Ill Patient Assessment of Rivaroxaban versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk",
"statusUsableDate" : "2018-09-13",
"briefResultsDescription" : "Rivaroxaban does not prevent VTE in medically ill patients",
"published" : "2017-08-27",
"pageName" : "MARINER",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "MARINER",
"title" : "Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness",
"pmid" : "30145946"
},
{
"timestamp" : "2017-12-03T22:37:27Z",
"briefDesignDescription" : "US screening for AAA in men",
"fulltexturl" : "http://www.bmj.com/content/338/bmj.b2307.long",
"pageid" : 2397,
"pdfurl" : "http://www.bmj.com/content/338/bmj.b2307.full.pdf",
"trainingLevel" : "Intern",
"citation" : "Thompson SG, et al. \"Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study\". BMJ. 2009. 338:b2307.",
"subspecialties" : "Preventive Medicine;Radiology",
"expansion" : "Multicentre Aneurysm Screening Study",
"statusUsableDate" : "2015-10-01",
"briefResultsDescription" : "US screening reduces AAA mortality in men",
"published" : "2009-06-24",
"pageName" : "MASS",
"diseases" : "Abdominal Aortic Aneurysm",
"abbreviation" : "MASS",
"title" : "Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study",
"pmid" : "19553269"
},
{
"timestamp" : "2021-11-06T00:38:08Z",
"briefDesignDescription" : "Abbreviated DAPT in high-risk bleeding",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2108749",
"pageid" : 4443,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2108749",
"trainingLevel" : "resident",
"citation" : "Valgimigli M, et al. \"Dual antiplatelet therapy after PCI in patients at high bleeding risk\". The New England Journal of Medicine. 2021. 385(18):1643-1655.",
"subspecialties" : "Cardiology;Hematology",
"expansion" : "Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation with an Abbreviated versus Standard DAPT Regimen",
"statusUsableDate" : "2021-10-31",
"briefResultsDescription" : "Abbreviated DAPT non-inferior or superior for CVD and/or bleeding events",
"published" : "2021-10-28",
"pageName" : "MASTER DAPT",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "MASTER DAPT",
"title" : "Dual antiplatelet therapy after PCI in patients at high bleeding risk",
"pmid" : "34449185"
},
{
"timestamp" : "2017-12-03T22:37:28Z",
"briefDesignDescription" : "ASA/clopidogrel vs. clopidogrel in stroke",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)16721-4/fulltext",
"pageid" : 1125,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673604167214.pdf",
"trainingLevel" : "student",
"citation" : "Diener HC, et al. \"Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial\". The Lancet. 2004. 364(9431):331-337.",
"subspecialties" : "Neurology",
"expansion" : "Management of Atherothrombosis with Clopidogrel in High-risk patients",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "More major bleeding but no greater efficacy with combination therapy",
"published" : "2004-07-24",
"pageName" : "MATCH",
"diseases" : "Stroke",
"abbreviation" : "MATCH",
"title" : "Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial",
"pmid" : "15276392"
},
{
"timestamp" : "2023-08-03T18:17:01Z",
"briefDesignDescription" : "Heparin vs. bivalirudin in PCI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1507854",
"pageid" : 2485,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1507854",
"trainingLevel" : "Resident",
"citation" : "Valgimigli M, et al. \"Bivalirudin or unfractionated heparin in acute coronary syndromes\". New England Journal of Medicine. 2015. 373(11):997-1009.",
"subspecialties" : "Cardiology",
"expansion" : "Minimizing Adverse haemmhorragic events by TRansradial access site and systemic Implementation of angioX (MATRIX)",
"statusUsableDate" : "2023-07-29",
"briefResultsDescription" : "Bivalirudin equivalent to heparin for PCI",
"published" : "2015-09-10",
"pageName" : "MATRIX Antithrombin",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "MATRIX Antithrombin",
"title" : "Bivalirudin or unfractionated heparin in acute coronary syndromes",
"pmid" : "26324049"
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{
"timestamp" : "2022-04-21T19:13:41Z",
"briefDesignDescription" : "Piperacillin-tazobactam for ESBL bacteremia",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2702145",
"pageid" : 4422,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Harris PNA, et al. \"Effect of piperacillin-tazobactam vs. meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae Bloodstream Infection and ceftriaxone resistance: A randomized clinical trial\". JAMA. 2018. 320(10):984-994.",
"subspecialties" : "Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2022-04-21",
"briefResultsDescription" : "Piperacillin-tazobactam is inferior to meropenem for ESBL bacteremia",
"published" : "2018-09-11",
"pageName" : "MERINO",
"diseases" : "ESBL Bacteremia",
"abbreviation" : "MERINO",
"title" : "Effect of piperacillin-tazobactam vs. meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae Bloodstream Infection and ceftriaxone resistance: A randomized clinical trial",
"pmid" : "30208454"
},
{
"timestamp" : "2015-08-24T03:51:03Z",
"briefDesignDescription" : "Metoprolol in HFrEF",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140673699044402",
"pageid" : 130,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Fagerberg B, et al. \"Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure\". The Lancet. 1999. 353(9169):2001-7.",
"subspecialties" : "Cardiology",
"expansion" : "Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Metoprolol improves survival in NYHA II-IV HFrEF",
"published" : "1999-06-12",
"pageName" : "MERIT-HF",
"diseases" : "Heart Failure",
"abbreviation" : "MERIT-HF",
"title" : "Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure",
"pmid" : "10376614"
},
{
"timestamp" : "2017-12-03T22:37:29Z",
"briefDesignDescription" : "Surgery vs. PT in OA with meniscal tear",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1301408",
"pageid" : 1429,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1301408",
"trainingLevel" : "Student",
"citation" : "Katz JN, et al. \"Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis\". The New England Journal of Medicine. 2013. 368(18):1675-1684.",
"subspecialties" : "Surgery;Physical Medicine and Rehabilitation",
"expansion" : "Meniscal Tear in Osteoarthritis Research",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "Surgery no better than PT alone",
"published" : "2013-05-02",
"pageName" : "METEOR",
"diseases" : "Meniscal Tear;Osteoarthritis",
"abbreviation" : "METEOR",
"title" : "Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis",
"pmid" : "23506518"
},
{
"timestamp" : "2017-12-03T22:37:31Z",
"briefDesignDescription" : "Early surgery for MR",
"fulltexturl" : "",
"pageid" : 1787,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/927436/joi130034.pdf",
"trainingLevel" : "Resident",
"citation" : "Suri RM, et al. \"Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets\". JAMA. 2013. 310(6):609-616.",
"subspecialties" : "Cardiology",
"expansion" : "Mitral Regurgitation International Database",
"statusUsableDate" : "2014-02-01",
"briefResultsDescription" : "Early surgery reduces mortality in MR",
"published" : "2013-08-14",
"pageName" : "MIDA",
"diseases" : "Mitral Regurgitation",
"abbreviation" : "MIDA",
"title" : "Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets",
"pmid" : "23942679"
},
{
"timestamp" : "2022-11-02T14:33:46Z",
"briefDesignDescription" : "Antipsychotics in ICU delirium",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1808217",
"pageid" : 3741,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1808217",
"trainingLevel" : "resident",
"citation" : "Girard TD, et al. \"Haloperidol and ziprasidone for treatment of delirium in critical illness\". The New England Journal of Medicine. 2018. ePub 2018-10-22:1-12.",
"subspecialties" : "Psychiatry;Critical Care",
"expansion" : "Modifying the Impact of ICU-Associated Neurological Dysfunction–USA",
"statusUsableDate" : "2018-11-30",
"briefResultsDescription" : "Antipsychotics don't reduce days without delirium or coma in ICU",
"published" : "2018-10-22",
"pageName" : "MIND-USA",
"diseases" : "Delirium;Critical Illness",
"abbreviation" : "MIND-USA",
"title" : "Haloperidol and ziprasidone for treatment of delirium in critical illness",
"pmid" : "30346242"
},
{
"timestamp" : "2020-10-29T17:14:07Z",
"briefDesignDescription" : "Atorvastatin in UA/NSTEMI",
"fulltexturl" : "http://jama.ama-assn.org/content/285/13/1711.long",
"pageid" : 432,
"pdfurl" : "http://jama.ama-assn.org/content/285/13/1711.full.pdf",
"trainingLevel" : "Resident",
"citation" : "Schwartz GG, et al. \"Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes\". Journal of the American Medical Association. 2001. 285(13):1711-1718.",
"subspecialties" : "Cardiology",
"expansion" : "Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Atorvastatin reduced rate of CV events after UA/NSTEMI",
"published" : "2001-04-04",
"pageName" : "MIRACL",
"diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Hyperlipidemia",
"abbreviation" : "MIRACL",
"title" : "Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes",
"pmid" : "11277825"
},
{
"timestamp" : "2021-01-06T13:53:52Z",
"briefDesignDescription" : "tPA and/or DNase for pleural infection",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1012740",
"pageid" : 3757,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012740",
"trainingLevel" : "Fellow",
"citation" : "Rahman NM, et al. \"Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection\". The New England Journal of Medicine. 2011. 365(6):518-526.",
"subspecialties" : "Pulmonology;Infectious Disease",
"expansion" : "Second MIST trial",
"statusUsableDate" : "2020-12-31",
"briefResultsDescription" : "tPA+DNase with greatest reduction in size of effusion",
"published" : "2011-08-11",
"pageName" : "MIST2",
"diseases" : "Pleural Infection",
"abbreviation" : "MIST2",
"title" : "Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection",
"pmid" : "21830966"
},
{
"timestamp" : "2023-04-12T13:12:04Z",
"briefDesignDescription" : "Bezlotoxumab for C. diff recurrence prevention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602615",
"pageid" : 2931,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602615",
"trainingLevel" : "Resident",
"citation" : "Wilcox MH, et al. \"Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection\". New England Journal of Medicine. 2017. 376(4):305-317.",
"subspecialties" : "Gastroenterology;Infectious Disease",
"expansion" : "",
"statusUsableDate" : "2017-05-01",
"briefResultsDescription" : "Bezlotoxumab lowers recurrence rate of C. diff infection",
"published" : "2017-01-26",
"pageName" : "MODIFY I and II",
"diseases" : "Clostridium difficile",
"abbreviation" : "MODIFY I and II",
"title" : "Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection",
"pmid" : "28121498"
},
{
"timestamp" : "2018-06-29T18:08:40Z",
"briefDesignDescription" : "Centrifugal-flow LVAD vs. axial-flow LVAD in advanced HF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800866",
"pageid" : 3605,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800866",
"trainingLevel" : "Resident",
"citation" : "Mehra MR, et al. \"Two-year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure\". The New England Journal of Medicine. 2018. 378(15):1386-95.",
"subspecialties" : "Cardiology",
"expansion" : "Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3",
"statusUsableDate" : "2018-06-29",
"briefResultsDescription" : "Centrifugal-flow LVAD superior to axial-flow LVAD in advanced HF",
"published" : "2018-04-12",
"pageName" : "MOMENTUM 3",
"diseases" : "Heart Failure",
"abbreviation" : "MOMENTUM 3",
"title" : "Two-year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure",
"pmid" : "29526139"
},
{
"timestamp" : "2017-12-03T22:37:34Z",
"briefDesignDescription" : "Low-dose tPA for submassive PE",
"fulltexturl" : "http://www.ajconline.org/article/S0002-9149%2812%2902205-9/fulltext",
"pageid" : 1785,
"pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0002-9149/PIIS0002914912022059.pdf",
"trainingLevel" : "Intern",
"citation" : "Sharifi M, et al. \"Moderate pulmonary embolism treated with thrombolysis\". The American Journal of Cardiology. 2013. 111(2):273-277.",
"subspecialties" : "Critical Care;Pulmonology;Cardiology",
"expansion" : "Moderate Pulmonary Embolism Treated with Thrombolysis",
"statusUsableDate" : "2014-02-01",
"briefResultsDescription" : "Low-dose tPA reduces pulmonary HTN in submassive PE",
"published" : "2013-01-15",
"pageName" : "MOPETT",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "MOPETT",
"title" : "Moderate pulmonary embolism treated with thrombolysis",
"pmid" : "23102885"
},
{
"timestamp" : "2017-12-03T22:37:42Z",
"briefDesignDescription" : "Arthroscopy in knee OA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013259",
"pageid" : 1055,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013259",
"trainingLevel" : "Resident",
"citation" : "Moseley JB, et al. \"A controlled trial of arthroscopic surgery for osteoarthritis of the knee\". The New England Journal of Medicine. 2002. 347(2):81-88.",
"subspecialties" : "Surgery;Physical Medicine and Rehabilitation",
"expansion" : "",
"statusUsableDate" : "2012-11-01",
"briefResultsDescription" : "No difference between groups at 2 years",
"published" : "2002-07-11",
"pageName" : "Moseley Trial",
"diseases" : "Osteoarthritis",
"abbreviation" : "",
"title" : "A controlled trial of arthroscopic surgery for osteoarthritis of the knee",
"pmid" : "12110735"
},
{
"timestamp" : "2023-03-30T22:49:47Z",
"briefDesignDescription" : "Dual- vs. single-chamber pacing in bradycardia",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013040",
"pageid" : 2710,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013040",
"trainingLevel" : "Resident",
"citation" : "Lamas GA, et al. \"Ventricular pacing or dual-chamber pacing for sinus-node dysfunction\". The New England Journal of Medicine. 2002. 346(24):1854-62.",
"subspecialties" : "Cardiology",
"expansion" : "Ventricular pacing or dual-chamber pacing for sinus-node dysfunction",
"statusUsableDate" : "2023-03-30",
"briefResultsDescription" : "Dual-chamber pacing superior to single-chamber ventricular pacing",
"published" : "2002-06-13",
"pageName" : "MOST",
"diseases" : "Bradycardia",
"abbreviation" : "MOST",
"title" : "Ventricular pacing or dual-chamber pacing for sinus-node dysfunction",
"pmid" : "12063369"
},
{
"timestamp" : "2017-12-03T22:37:36Z",
"briefDesignDescription" : "Gemcitabine/nab-paclitaxel in pancreatic cancer",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1304369",
"pageid" : 2816,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1304369",
"trainingLevel" : "Resident",
"citation" : "Von Hoff DD, et al. \"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine\". The New England Journal of Medicine. 2013. 369(18):1691-1703.",
"subspecialties" : "Oncology",
"expansion" : "Metastatic Pancreatic Adenocarcinoma Clinical Trial",
"statusUsableDate" : "2016-08-01",
"briefResultsDescription" : "Gemcicabine/nab-paclitaxel improves OS in metastatic pancreatic cancer compared to gemcitabine",
"published" : "2013-10-31",
"pageName" : "MPACT",
"diseases" : "Pancreatic Cancer",
"abbreviation" : "MPACT",
"title" : "Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine",
"pmid" : "24131140"
},
{
"timestamp" : "2016-03-10T04:00:44Z",
"briefDesignDescription" : "IA therapy for proximal large artery strokes",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1411587",
"pageid" : 2373,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1411587",
"trainingLevel" : "Intern",
"citation" : "Berkhemer OA, et al. \"A randomized trial of intraarterial treatment for acute ischemic stroke\". The New England Journal of Medicine. 2015. 372(1):11-20.",
"subspecialties" : "Neurology",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "IA therapy improves outcome without increased mortality or ICH",
"published" : "2015-01-01",
"pageName" : "MR CLEAN",
"diseases" : "Stroke",
"abbreviation" : "MR CLEAN",
"title" : "A randomized trial of intraarterial treatment for acute ischemic stroke",
"pmid" : "25517348"
},
{
"timestamp" : "2017-12-03T22:37:37Z",
"briefDesignDescription" : "Thrombectomy vs. standard care in stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212793",
"pageid" : 2363,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212793",
"trainingLevel" : "Fellow",
"citation" : "Kidwell CS, et al. \"A trial of imaging selection and endovascular treatment for ischemic stroke\". The New England Journal of Medicine. 2013. 368(10):914-923.",
"subspecialties" : "Neurology",
"expansion" : "",
"statusUsableDate" : "2015-05-01",
"briefResultsDescription" : "Imaging did not id pts who would benefit from endovascular thrombectomy for acute ischemic stroke.",
"published" : "2013-03-07",
"pageName" : "MR RESCUE",
"diseases" : "Stroke",
"abbreviation" : "MR RESCUE",
"title" : "A trial of imaging selection and endovascular treatment for ischemic stroke",
"pmid" : "23394476"
},
{
"timestamp" : "2021-06-25T23:51:15Z",
"briefDesignDescription" : "CHD risk modification for CHD mortality prevention",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/377969",
"pageid" : 2455,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "MRFIT Writers. \"Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group\". JAMA. 1982. 248(12):1465-1477.",
"subspecialties" : "Cardiology;Preventive Medicine",
"expansion" : "Multiple Risk Factor Intervention Trial",
"statusUsableDate" : "2021-06-24",
"briefResultsDescription" : "CHD risk modification did not lower 7 year mortality",
"published" : "1982-09-24",
"pageName" : "MRFIT",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "MRFIT",
"title" : "Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group",
"pmid" : "7050440"
},
{
"timestamp" : "2021-01-05T21:08:12Z",
"briefDesignDescription" : "Hydroxyurea in sickle-cell disease",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199505183322001",
"pageid" : 2797,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199505183322001",
"trainingLevel" : "Student",
"citation" : "Charache S, et al. \"Effect of hydroxyurea on the frequency of painful crises in sickle-cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle-Cell Anemia\". The New England Journal of Medicine. 1995. 332(20):1317-1322.",
"subspecialties" : "Hematology",
"expansion" : "Multicenter Study of Hydroxyurea in Sickle-Cell Anemia",
"statusUsableDate" : "2016-07-01",
"briefResultsDescription" : "Hydroxyurea ↓frequency of painful crises in SCD",
"published" : "1995-05-18",
"pageName" : "MSH",
"diseases" : "Sickle Cell Disease",
"abbreviation" : "MSH",
"title" : "Effect of hydroxyurea on the frequency of painful crises in sickle-cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle-Cell Anemia",
"pmid" : "7715639"
},
{
"timestamp" : "2024-03-28T20:26:52Z",
"briefDesignDescription" : "SLNB vs. surveillance in melanoma",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1310460",
"pageid" : 3521,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1310460",
"trainingLevel" : "Fellow",
"citation" : "Morton DL, et al. \"Multicenter Selective Lymphadenectomy Trial\". The New England Journal of Medicine. 2014. 370(7):599-609.",
"subspecialties" : "Surgery;Oncology",
"expansion" : "Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma",
"statusUsableDate" : "2024-03-28",
"briefResultsDescription" : "SLBN did not improve melanoma-specific survival compared to observation",
"published" : "2014-02-13",
"pageName" : "MSLT-1",
"diseases" : "Melanoma",
"abbreviation" : "MSLT-I",
"title" : "Multicenter Selective Lymphadenectomy Trial",
"pmid" : "24521106"
},
{
"timestamp" : "2022-12-01T19:00:15Z",
"briefDesignDescription" : "ICD and antiarrhythmics in mild HFrEF and NSVT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199912163412503",
"pageid" : 2872,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199912163412503",
"trainingLevel" : "Resident",
"citation" : "Buxton AE et al. \"A randomized study of the prevention of sudden death in patients with coronary artery disease\". New Engl J Med. 1999. 341(25):1882-90.",
"subspecialties" : "Cardiology",
"expansion" : "Multicenter Unsustained Tachycardia Trial",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "ICD placement better than antiarrhythmics in mild HF with NSVT",
"published" : "1999-12-16",
"pageName" : "MUSTT",
"diseases" : "Ventricular Tachycardia",
"abbreviation" : "MUSTT",
"title" : "A randomized study of the prevention of sudden death in patients with coronary artery disease",
"pmid" : "10601507"
},
{
"timestamp" : "2017-12-03T22:37:44Z",
"briefDesignDescription" : "Early vs. delayed ART in HIV",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807252",
"pageid" : 1039,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807252",
"trainingLevel" : "Resident",
"citation" : "Kitahata MM, et al. \"Effect of Early vs. Deferred Antiretroviral therapy for HIV on Survival\". The New England Journal of Medicine. 2009. 360(18):1815-1826.",
"subspecialties" : "Infectious Disease",
"expansion" : "North American AIDS Cohort Collaboration on Research and Design",
"statusUsableDate" : "2014-11-01",
"briefResultsDescription" : "Early ART in HIV improves survival",
"published" : "2009-04-30",
"pageName" : "NA-ACCORD",
"diseases" : "HIV",
"abbreviation" : "NA-ACCORD",
"title" : "Effect of Early vs. Deferred Antiretroviral therapy for HIV on Survival",
"pmid" : "19339714"
},
{
"timestamp" : "2022-07-29T01:52:18Z",
"briefDesignDescription" : "12 vs. 20 hours of NAC in APAP overdose",
"fulltexturl" : "https://doi.org/10.1002/hep.30224",
"pageid" : 4063,
"pdfurl" : "https://aasldpubs.onlinelibrary.wiley.com/doi/epdf/10.1002/hep.30224",
"trainingLevel" : "resident",
"citation" : "Wong A. \"The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose\". Hepatology. 2019. 69(2):774-784.",
"subspecialties" : "Emergency Medicine;Critical Care",
"expansion" : "",
"statusUsableDate" : "2022-07-15",
"briefResultsDescription" : "No difference between 12 vs. 20 hours of NAC for APAP overdose",
"published" : "2019-02-02",
"pageName" : "NACSTOP",
"diseases" : "Acetaminophen Overdose",
"abbreviation" : "NACSTOP",
"title" : "The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose",
"pmid" : "30125376"
},
{
"timestamp" : "2020-08-01T21:47:56Z",
"briefDesignDescription" : "CEA in symptomatic carotid stenosis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199811123392002",
"pageid" : 128,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199811123392002",
"trainingLevel" : "Intern",
"citation" : "Barnett HJ, et al. \"Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis\". The New England Journal of Medicine. 1998. 339(20):1415-25.",
"subspecialties" : "Surgery;Neurology",
"expansion" : "North American Symptomatic Carotid Endarterectomy Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "CEA reduces the risk of death or stroke in symptomatic 50-69% carotid stenosis",
"published" : "1998-11-12",
"pageName" : "NASCET",
"diseases" : "Carotid Stenosis;Stroke",
"abbreviation" : "NASCET",
"title" : "Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis",
"pmid" : "9811916"
},
{
"timestamp" : "2022-10-19T13:06:44Z",
"briefDesignDescription" : "Rivaroxaban vs. ASA for ESUS (stroke)",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1802686",
"pageid" : 3665,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1802686",
"trainingLevel" : "Resident",
"citation" : "Hart RG, et al. \"Rivaroxaban for stroke prevention after embolic stroke of undetermined source\". The New England Journal of Medicine. 2018. 378(23):2191-2201.",
"subspecialties" : "Neurology",
"expansion" : "New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source\nof Undetermined Source",
"statusUsableDate" : "2022-07-28",
"briefResultsDescription" : "Rivaroxaban is not superior to ASA for stroke",
"published" : "2018-06-07",
"pageName" : "NAVIGATE ESUS",
"diseases" : "Stroke",
"abbreviation" : "NAVIGATE ESUS",
"title" : "Rivaroxaban for stroke prevention after embolic stroke of undetermined source",
"pmid" : "29766772"
},
{
"timestamp" : "2017-12-03T22:37:45Z",
"briefDesignDescription" : "Dialysis prescriptions in ESRD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198111123052003",
"pageid" : 504,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198111123052003",
"trainingLevel" : "Fellow",
"citation" : "Lowrie EG, et al. \"Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study\". The New England Journal of Medicine. 1981. 305(20):1176-1181.",
"subspecialties" : "Nephrology",
"expansion" : "The National Cooperative Dialysis Study",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Low BUN better tolerated, fewer hospitalizations",
"published" : "1981-11-12",
"pageName" : "NCDS",
"diseases" : "Chronic Kidney Disease",
"abbreviation" : "NCDS",
"title" : "Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study",
"pmid" : "7027040"
},
{
"timestamp" : "2017-12-03T22:37:47Z",
"briefDesignDescription" : "Nitrates for activity tolerance in HFpEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1510774",
"pageid" : 2668,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510774",
"trainingLevel" : "Resident",
"citation" : "Redfield MM, et al. \"Isosorbide mononitrate in heart failure with preserved ejection fraction\". New England Journal of Medicine. 2015. 373(24):2314-2324.",
"subspecialties" : "Cardiology",
"expansion" : "Nitrate’s Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction",
"statusUsableDate" : "2016-04-01",
"briefResultsDescription" : "Nitrates do not improve activity tolerance in HFpEF",
"published" : "2015-12-10",
"pageName" : "NEAT-HFpEF",
"diseases" : "Heart Failure",
"abbreviation" : "NEAT-HFpEF",
"title" : "Isosorbide mononitrate in heart failure with preserved ejection fraction",
"pmid" : "26549714"
},
{
"timestamp" : "2017-12-03T22:37:49Z",
"briefDesignDescription" : "Lung volume reduction in COPD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030287",
"pageid" : 1604,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030287",
"trainingLevel" : "Resident",
"citation" : "Fishman A, et al. \"A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema\". The New England Journal of Medicine. 2003. 348(21):2059-2073.",
"subspecialties" : "Surgery;Pulmonology",
"expansion" : "National Emphysema Treatment Trial",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "LVRS benefits apical emphysema and those with low exercise function",
"published" : "2003-05-22",
"pageName" : "NETT",
"diseases" : "Chronic Obstructive Pulmonary Disease;Emphysema",
"abbreviation" : "NETT",
"title" : "A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema",
"pmid" : "12759479"
},
{
"timestamp" : "2020-02-06T15:48:50Z",
"briefDesignDescription" : "Intensive glycemic therapy in ICU",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810625",
"pageid" : 26,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810625",
"trainingLevel" : "Intern",
"citation" : "Finfer S, et al. \"Intensive versus conventional glucose control in critically ill patients\". The New England Journal of Medicine. 2009. 360(13):1283-1297.",
"subspecialties" : "Critical Care;Endocrinology",
"expansion" : "Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Increased mortality targeting euglycemia",
"published" : "2009-03-26",
"pageName" : "NICE-SUGAR",
"diseases" : "Stress Hyperglycemia",
"abbreviation" : "NICE-SUGAR",
"title" : "Intensive versus conventional glucose control in critically ill patients",
"pmid" : "19318384"
},
{
"timestamp" : "2015-08-24T19:41:34Z",
"briefDesignDescription" : "tPA in ischemic stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199512143332401",
"pageid" : 131,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199512143332401",
"trainingLevel" : "MedicalStudent",
"citation" : "Marler JR, et al. \"Tissue Plasminogen Activator for Acute Ischemic Stroke\". The New England Journal of Medicine. 1995. 333(24):1581-1587.",
"subspecialties" : "Neurology;Critical Care",
"expansion" : "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "tPA within 3 hours improved outcomes",
"published" : "1995-12-14",
"pageName" : "NINDS",
"diseases" : "Stroke",
"abbreviation" : "NINDS",
"title" : "Tissue Plasminogen Activator for Acute Ischemic Stroke",
"pmid" : "7477192"
},
{
"timestamp" : "2017-12-03T22:37:50Z",
"briefDesignDescription" : "CT vs. CXR in lung cancer screening",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102873",
"pageid" : 980,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102873",
"trainingLevel" : "Resident",
"citation" : "Berg CD, et al. \"Reduced lung cancer mortality with low-dose computed tomographic screening\". The New England Journal of Medicine. 2011. 365(5):395-409.",
"subspecialties" : "Pulmonology;Oncology;Preventive Medicine",
"expansion" : "National Lung Screening Trial",
"statusUsableDate" : "2012-10-01",
"briefResultsDescription" : "Low-dose CT reduces lung cancer mortality compared to CXR",
"published" : "2011-08-04",
"pageName" : "NLST",
"diseases" : "Lung Cancer",
"abbreviation" : "NLST",
"title" : "Reduced lung cancer mortality with low-dose computed tomographic screening",
"pmid" : "21714641"
},
{
"timestamp" : "2022-12-01T20:16:39Z",
"briefDesignDescription" : "Invitations for screening colonoscopy",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2208375",
"pageid" : 5065,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2208375",
"trainingLevel" : "resident",
"citation" : "Bretthauer M, et al. \"Effect of colonoscopy screening on risks of colorectal cancer and related death\". The New England Journal of Medicine. 2022. 1-10.",
"subspecialties" : "Preventive Medicine",
"expansion" : "Nordic-European Initiative on Colorectal Cancer",
"statusUsableDate" : "2022-10-14",
"briefResultsDescription" : "Invitations for screening colonoscopy don't lower mortality",
"published" : "2022-10-09",
"pageName" : "NordICC",
"diseases" : "Colorectal Cancer",
"abbreviation" : "NordICC",
"title" : "Effect of colonoscopy screening on risks of colorectal cancer and related death",
"pmid" : "36214590"
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{
"timestamp" : "2021-01-30T21:12:28Z",
"briefDesignDescription" : "Drug-eluting stent vs. bare-metal stent in CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1607991",
"pageid" : 2832,
"pdfurl" : "http://www.nejm.org/pdf/full/10.1056/NEJMoa1607991",
"trainingLevel" : "Resident",
"citation" : "Bonaa KH, et al. \"Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease\". The New England Journal of Medicine. 2016. 375:1242-1252.",
"subspecialties" : "Cardiology",
"expansion" : "Drug-Eluting or Bare-Metal Stents for Percutaneous Coronary Intervention in Stable or Unstable Coronary Artery Disease",
"statusUsableDate" : "2016-10-01",
"briefResultsDescription" : "Drug-eluting stent superior to bare-metal stent in CAD",
"published" : "2016-08-30",
"pageName" : "NORSTENT",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "NORSTENT",
"title" : "Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease",
"pmid" : "27572953"
},
{
"timestamp" : "2017-12-03T22:37:53Z",
"briefDesignDescription" : "Continuous vs. nocturnal oxygen in COPD",
"fulltexturl" : "http://annals.org/article.aspx?articleid",
"pageid" : 1788,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "NOTT Group. \"Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group\". Annals of Internal Medicine. 1980. 93(3):91-398.",
"subspecialties" : "Pulmonology",
"expansion" : "Nocturnal Oxygen Therapy Trial",
"statusUsableDate" : "2014-01-01",
"briefResultsDescription" : "Continuous oxygen reduces mortality in COPD with hypoxemia",
"published" : "1980-09-01",
"pageName" : "NOTT",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"abbreviation" : "NOTT",
"title" : "Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group",
"pmid" : "6776858"
},
{
"timestamp" : "2021-05-31T17:57:36Z",
"briefDesignDescription" : "ICS+LABA PRN in mild asthma",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1901963",
"pageid" : 4142,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1901963",
"trainingLevel" : "resident",
"citation" : "Beasley R, et al. \"Controlled trial of budesonide+formoterol as needed for mild asthma\". The New England Journal of Medicine. 2019. 380(21):2020-2030.",
"subspecialties" : "Pulmonology",
"expansion" : "Novel Symbicort Turbuhaler Asthma Reliever Therapy",
"statusUsableDate" : "2021-05-20",
"briefResultsDescription" : "ICS+LABA PRN with fewer overall, but more severe exacerbations",
"published" : "2019-05-23",
"pageName" : "Novel START",
"diseases" : "Asthma",
"abbreviation" : "Novel START",
"title" : "Controlled trial of budesonide+formoterol as needed for mild asthma",
"pmid" : "31112386"
},
{
"timestamp" : "2018-09-06T17:17:20Z",
"briefDesignDescription" : "Sentinel LN biopsy in breast cancer",
"fulltexturl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041644/",
"pageid" : 1167,
"pdfurl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041644/pdf/nihms-250175.pdf",
"trainingLevel" : "Student",
"citation" : "Krag DN, et al. \"Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial\". Lancet Oncology. 2010. 11(10):927-933.",
"subspecialties" : "Oncology",
"expansion" : "National Surgical Adjuvant Breast and Bowel Project Trial B-32",
"statusUsableDate" : "2013-02-01",
"briefResultsDescription" : "Sentinel lymph node biopsy is equally efficacious but has fewer side effects than ALND",
"published" : "2010-10-01",
"pageName" : "NSABP B-32",
"diseases" : "Breast Cancer",
"abbreviation" : "NSABP B-32",
"title" : "Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial",
"pmid" : "20863759"
},
{
"timestamp" : "2017-12-03T22:37:56Z",
"briefDesignDescription" : "Tamoxifen in breast cancer prevention",
"fulltexturl" : "http://jnci.oxfordjournals.org/content/90/18/1371.long",
"pageid" : 1049,
"pdfurl" : "http://jnci.oxfordjournals.org/content/90/18/1371.full.pdf+html",
"trainingLevel" : "resident",
"citation" : "Fisher B, et al. \"Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study\". Journal of the National Cancer Institute. 1998. 90(18):1371-1388.",
"subspecialties" : "Oncology;Preventive Medicine",
"expansion" : "National Surgical Adjuvant Breast and Bowel Project, Prevention-1",
"statusUsableDate" : "2012-10-01",
"briefResultsDescription" : "Tamoxifen reduces breast cancer incidence by 48%",
"published" : "1998-09-16",
"pageName" : "NSABP P-1",
"diseases" : "Breast Cancer",
"abbreviation" : "NSABP P-1",
"title" : "Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study",
"pmid" : "9747868"
},
{
"timestamp" : "2018-04-26T20:18:28Z",
"briefDesignDescription" : "Fondaparinux vs. enoxaparin in NSTE-ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa055443",
"pageid" : 2484,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa055443",
"trainingLevel" : "intern",
"citation" : "Yusuf S, et al. \"Comparison of fondaparinux and enoxaparin in acute coronary syndromes\". The New England Journal of Medicine. 2006. 354(14):1464-1476.",
"subspecialties" : "Cardiology",
"expansion" : "Fifth Organization to Assess Strategies in Acute Ischemic Syndromes",
"statusUsableDate" : "2018-04-27",
"briefResultsDescription" : "Fondaparinux is non-inferior to enoxaparin in NSTE-ACS",
"published" : "2006-04-06",
"pageName" : "OASIS-5",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "OASIS-5",
"title" : "Comparison of fondaparinux and enoxaparin in acute coronary syndromes",
"pmid" : "16537663"
},
{
"timestamp" : "2020-09-14T19:27:00Z",
"briefDesignDescription" : "PCI+OMT vs. OMT 3-28 days after MI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa066139",
"pageid" : 2676,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa066139",
"trainingLevel" : "Intern",
"citation" : "Hochman J.S., et al. \"Coronary Intervention for Persistent Occlusion after Myocardial Infarction\". The New England Journal of Medicine. 2006. 355(23):2395-2407.",
"subspecialties" : "Cardiology",
"expansion" : "Occluded Artery Trial",
"statusUsableDate" : "2016-06-01",
"briefResultsDescription" : "PCI+OMT no better than OMT 3-28 days after MI",
"published" : "2006-12-07",
"pageName" : "OAT",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"abbreviation" : "OAT",
"title" : "Coronary Intervention for Persistent Occlusion after Myocardial Infarction",
"pmid" : "17105759"
},
{
"timestamp" : "2017-12-14T19:48:32Z",
"briefDesignDescription" : "PCSK9 inhibitor alirocumab for HLD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501031",
"pageid" : 2423,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501031",
"trainingLevel" : "Student",
"citation" : "Robinson JG, et al. \"Efficacy and safety of alirocumab in reducing lipids and cardiovascular events\". The New England Journal of Medicine. 2015. 372(16):1489-1499.",
"subspecialties" : "Cardiology",
"expansion" : "Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not\nAdequately Controlled with Their Lipid Modifying Therapy",
"statusUsableDate" : "2015-09-01",
"briefResultsDescription" : "Alirocumab lowers LDL, reduces non-fatal MI",
"published" : "2015-04-16",
"pageName" : "ODYSSEY LONG TERM",
"diseases" : "Hyperlipidemia",
"abbreviation" : "ODYSSEY LONG TERM",
"title" : "Efficacy and safety of alirocumab in reducing lipids and cardiovascular events",
"pmid" : "25773378"
},
{
"timestamp" : "2016-04-01T23:27:21Z",
"briefDesignDescription" : "IV PPI for GI bleeds",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200008033430501",
"pageid" : 247,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200008033430501",
"trainingLevel" : "Resident",
"citation" : "Lau JYW, et al. \"Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcer\". The New England Journal of Medicine. 2000. 343(5):310-316.",
"subspecialties" : "Gastroenterology",
"expansion" : null,
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "IV omeprazole reduced 30-day rebleeding",
"published" : "2000-08-03",
"pageName" : "Omeprazole in Peptic Ulcer Bleeding",
"diseases" : "Gastrointestinal Hemorrhage",
"abbreviation" : null,
"title" : "Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcer",
"pmid" : "10922420"
},
{
"timestamp" : "2017-12-03T22:38:00Z",
"briefDesignDescription" : "Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801317",
"pageid" : 1776,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801317",
"trainingLevel" : "Resident",
"citation" : "Yusuf S, et al. \"Telmisartan, ramipril, or both in patients at high risk for vascular events\". The New England Journal of Medicine. 2008. 358(15):1547-1559.",
"subspecialties" : "Cardiology;Nephrology;Endocrinology",
"expansion" : "Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial",
"statusUsableDate" : "2014-05-01",
"briefResultsDescription" : "No difference in CV complications, combination ACE-inhibitor and ARB poorly tolerated",
"published" : "2008-04-10",
"pageName" : "ONTARGET",
"diseases" : "Cardiovascular Disease;Diabetes Mellitus;Stroke",
"abbreviation" : "ONTARGET",
"title" : "Telmisartan, ramipril, or both in patients at high risk for vascular events",
"pmid" : "18378520"
},
{
"timestamp" : "2019-04-23T20:57:22Z",
"briefDesignDescription" : "ASA/warfarin vs. warfarin in AF",
"fulltexturl" : "http://circ.ahajournals.org/content/128/7/721.long",
"pageid" : 1769,
"pdfurl" : "http://circ.ahajournals.org/content/128/7/721.full.pdf",
"trainingLevel" : "Fellow",
"citation" : "Steinberg BA, et al. \"Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry\". Circulation. 2013. 128(7):721-8.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Outcomes Registry for Better Informed Treatment of Atrial Fibrillation",
"statusUsableDate" : "2014-06-01",
"briefResultsDescription" : "ASA/warfarin associated with more bleeding, fewer CV events",
"published" : "2013-08-13",
"pageName" : "ORBIT-AF",
"diseases" : "Atrial Fibrillation;Stroke",
"abbreviation" : "ORBIT-AF",
"title" : "Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry",
"pmid" : "23861512"
},
{
"timestamp" : "2018-03-08T17:42:17Z",
"briefDesignDescription" : "PCI vs. medical therapy in stable angina",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32714-9/fulltext",
"pageid" : 3499,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(17)32714-9.pdf",
"trainingLevel" : "Resident",
"citation" : "Al-Lamee R, et al. \"Percutaneous coronary intervention in stable angina\". Lancet. 2017. epub 2017-11-02:1-11.",
"subspecialties" : "Cardiology",
"expansion" : "Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina",
"statusUsableDate" : "2017-12-14",
"briefResultsDescription" : "PCI not superior to medical therapy in stable angina",
"published" : "2017-11-02",
"pageName" : "ORBITA",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "ORBITA",
"title" : "Percutaneous coronary intervention in stable angina",
"pmid" : "29103656"
},
{
"timestamp" : "2017-12-03T22:38:03Z",
"briefDesignDescription" : "Fish oil for high-risk CVD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1203859",
"pageid" : 2330,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1203859",
"trainingLevel" : "Intern",
"citation" : "Bosch J, et al. \"n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia\". The New England Journal of Medicine. 2012. 367(4):309-318.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Investigators in the outcome Reduction with an Initial Glargine Intervention",
"statusUsableDate" : "2015-02-01",
"briefResultsDescription" : "n-3 fatty acids don't reduce CVD",
"published" : "2012-07-26",
"pageName" : "ORIGIN n-3 Fatty Acids",
"diseases" : "Cardiovascular Disease;Coronary Artery Disease;Stroke",
"abbreviation" : "ORIGIN n-3 Fatty Acids",
"title" : "n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia",
"pmid" : "22686415"
},
{
"timestamp" : "2017-12-03T22:38:05Z",
"briefDesignDescription" : "High-frequency oscillatory vent in early ARDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1215554",
"pageid" : 1254,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1215554",
"trainingLevel" : "Resident",
"citation" : "Ferguson ND, et al. \"High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome\". The New England Journal of Medicine. 2013. 368(9):795-805.",
"subspecialties" : "Critical Care;Pulmonology",
"expansion" : "Oscillation for Acute Respiratory Distress Syndrome Treated Early",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "High-frequency oscillatory vent may harm in early ARDS",
"published" : "2013-02-28",
"pageName" : "OSCILLATE",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "Oscillate",
"title" : "High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome",
"pmid" : "23339639"
},
{
"timestamp" : "2019-10-08T15:46:44Z",
"briefDesignDescription" : "PO vs. IV antibiotics for bone/joint infection",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1710926",
"pageid" : 3542,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1710926",
"trainingLevel" : "student",
"citation" : "Li HK, et al. \"Oral versus Intravenous Antibiotics for Bone and Joint Infection\". The New England Journal of Medicine. 2019. 380(5):425-436.",
"subspecialties" : "Infectious Disease",
"expansion" : "Oral versus Intravenous Antibiotics for Bone and Joint Infection",
"statusUsableDate" : "2019-04-11",
"briefResultsDescription" : "PO non-inferior to IV antibiotics for selected bone/joint infections",
"published" : "2019-01-31",
"pageName" : "OVIVA",
"diseases" : "Osteomyelitis",
"abbreviation" : "OVIVA",
"title" : "Oral versus Intravenous Antibiotics for Bone and Joint Infection",
"pmid" : "30699315"
},
{
"timestamp" : "2019-08-31T19:06:09Z",
"briefDesignDescription" : "Step-up approach to pancreatitis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0908821",
"pageid" : 398,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0908821",
"trainingLevel" : "Fellow",
"citation" : "van Santvoort HC, et al. \"A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis\". The New England Journal of Medicine. 2010. 362(16):1491-502.",
"subspecialties" : "Surgery;Gastroenterology",
"expansion" : "Minimally Invasive Step Up Approach versus Maximal Necrosectomy in Patients with Acute Necrotising Pancreatitis",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Step-up approach reduces major complications and death",
"published" : "2010-04-22",
"pageName" : "PANTER",
"diseases" : "Pancreatitis",
"abbreviation" : "PANTER",
"title" : "A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis",
"pmid" : "20410514"
},
{
"timestamp" : "2021-07-28T06:20:24Z",
"briefDesignDescription" : "ARNI vs. enalapril in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409077",
"pageid" : 2163,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409077",
"trainingLevel" : "Resident",
"citation" : "McMurray JJV, et al. \"Angiotensin-neprilysin inhibition versus enalapril in heart failure\". The New England Journal of Medicine. 2014. 371(11):993-1004.",
"subspecialties" : "Cardiology",
"expansion" : "Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure",
"statusUsableDate" : "2014-09-01",
"briefResultsDescription" : "ARNI reduces mortality in HFrEF",
"published" : "2014-08-30",
"pageName" : "PARADIGM-HF",
"diseases" : "Heart Failure",
"abbreviation" : "PARADIGM-HF",
"title" : "Angiotensin-neprilysin inhibition versus enalapril in heart failure",
"pmid" : "25176015"
},
{
"timestamp" : "2020-07-02T17:06:36Z",
"briefDesignDescription" : "ARNI in symptomatic HFpEF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1908655",
"pageid" : 4184,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1908655",
"trainingLevel" : "Resident",
"citation" : "Solomon SD, et al. \"Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction\". The New England Journal of Medicine. 2019. 381(17):1609-1620.",
"subspecialties" : "Cardiology",
"expansion" : "Prospective Comparison of ARNI Global Outcomes in HF with Preserved Ejection Fraction",
"statusUsableDate" : "2020-07-02",
"briefResultsDescription" : "No benefit from ARNI in HFpEF",
"published" : "2019-10-24",
"pageName" : "PARAGON-HF",
"diseases" : "Heart Failure",
"abbreviation" : "PARAGON-HF",
"title" : "Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction",
"pmid" : "32187481"
},
{
"timestamp" : "2017-12-03T22:38:08Z",
"briefDesignDescription" : "Maintenance pemetrexed in lung cancer",
"fulltexturl" : "http://jco.ascopubs.org/content/31/23/2895.long",
"pageid" : 1606,
"pdfurl" : "http://jco.ascopubs.org/content/31/23/2895.full.pdf",
"trainingLevel" : "Fellow",
"citation" : "Paz-Ares LG, et al. \"PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer\". Journal of Clinical Oncology. 2013. 31(23):2895-902.",
"subspecialties" : "Oncology",
"expansion" : "",
"statusUsableDate" : "2014-01-01",
"briefResultsDescription" : "Maintenance pemetrexed improves PFS and OS following induction with cisplatin/pemetrexed",
"published" : "2013-08-10",
"pageName" : "PARAMOUNT",
"diseases" : "Lung Cancer",
"abbreviation" : "PARAMOUNT",
"title" : "PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer",
"pmid" : "23835707"
},
{
"timestamp" : "2017-12-03T22:38:09Z",
"briefDesignDescription" : "TAVI for AS in intermediate-risk surgical candidates",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1514616",
"pageid" : 2753,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1514616",
"trainingLevel" : "Resident",
"citation" : "Leon MB, et al. \"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients\". The New England Journal of Medicine. 2016. 374(17):1609-20.",
"subspecialties" : "Cardiology",
"expansion" : "Placement of Aortic Transcatheter Valves, Cohort A",
"statusUsableDate" : "2016-05-01",
"briefResultsDescription" : "TAVI noninferior to surgical AVR in intermediate-risk surgical candidates",
"published" : "2016-04-28",
"pageName" : "PARTNER 2",
"diseases" : "Aortic Stenosis",
"abbreviation" : "PARTNER 2",
"title" : "Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients",
"pmid" : "27040324"
},
{
"timestamp" : "2019-10-17T18:34:54Z",
"briefDesignDescription" : "TAVR for AS in low-risk surgical candidates",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1814052",
"pageid" : 3949,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1814052",
"trainingLevel" : "Resident",
"citation" : "Mack MJ, et al. \"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients\". The New England Journal of Medicine. 2019. 380(18):1695-1705.",
"subspecialties" : "Cardiology",
"expansion" : "Placement of Aortic Transcatheter Valves 3",
"statusUsableDate" : "2019-10-16",
"briefResultsDescription" : "TAVR superior to surgical AVR in low-risk surgical candidates",
"published" : "2019-03-16",
"pageName" : "PARTNER 3",
"diseases" : "Aortic Stenosis",
"abbreviation" : "PARTNER 3",
"title" : "Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients",
"pmid" : "30883058"
},
{
"timestamp" : "2017-12-03T22:38:10Z",
"briefDesignDescription" : "TAVI for AS in high-risk surgical candidates",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1103510",
"pageid" : 2741,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1103510",
"trainingLevel" : "Intern",
"citation" : "Smith CR, et al. \"Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients\". The New England Journal of Medicine. 2011. 364(23):2187-98.",
"subspecialties" : "Cardiology",
"expansion" : "Placement of Aortic Transcatheter Valves, Cohort A",
"statusUsableDate" : "2016-05-01",
"briefResultsDescription" : "TAVI noninferior to surgical AVR in high-risk surgical candidates",
"published" : "2011-06-09",
"pageName" : "PARTNER A",
"diseases" : "Aortic Stenosis",
"abbreviation" : "PARTNER A",
"title" : "Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients",
"pmid" : "21639811"
},
{
"timestamp" : "2017-12-03T22:38:12Z",
"briefDesignDescription" : "TAVI for AS in poor surgical candidates",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1008232",
"pageid" : 1674,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1008232",
"trainingLevel" : "Intern",
"citation" : "Leon MB, et al. \"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery\". The New England Journal of Medicine. 2010. 363(17):1597-1607.",
"subspecialties" : "Cardiology",
"expansion" : "Placement of Aortic Transcatheter Valves, Cohort B",
"statusUsableDate" : "2013-12-01",
"briefResultsDescription" : "TAVI reduces all-cause mortality ± rehospitalization, increased stroke",
"published" : "2010-10-21",
"pageName" : "PARTNER B",
"diseases" : "Aortic Stenosis",
"abbreviation" : "PARTNER B",
"title" : "Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery",
"pmid" : "20961243"
},
{
"timestamp" : "2021-02-12T16:58:50Z",
"briefDesignDescription" : "Spironolactone for resistant HTN",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(15)00257-3",
"pageid" : 2733,
"pdfurl" : "http://bit.ly/pathway-2-pdf",
"trainingLevel" : "Resident",
"citation" : "Williams B, et al. \"Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial\". The Lancet. 2015. 386(10008):2059-2068.",
"subspecialties" : "Cardiology;Nephrology;Preventive Medicine",
"expansion" : "Prevention and Treatment of Hypertension with Algorithm-Based Therapy (PATHWAY)",
"statusUsableDate" : "2021-02-11",
"briefResultsDescription" : "Spironolactone improved BP control compared to placebo, doxazosin, or bisoprolol",
"published" : "2015-11-21",
"pageName" : "PATHWAY-2",
"diseases" : "Hypertension",
"abbreviation" : "PATHWAY-2",
"title" : "Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial",
"pmid" : "26414968"
},
{
"timestamp" : "2021-05-12T12:54:33Z",
"briefDesignDescription" : "Perioperative DOAC holding protocols in AF",
"fulltexturl" : "https://doi.org/10.1001/jamainternmed.2019.2431",
"pageid" : 4421,
"pdfurl" : "",
"trainingLevel" : "fellow",
"citation" : "Douketis JD, et al. \"Perioperative management of patients with atrial fibrillation receiving a direct oral anticoagulant\". JAMA Internal Medicine. 2019. 179(11):1469-1478.",
"subspecialties" : "Cardiology",
"expansion" : "Perioperative Anticoagulation Use for Surgery Evaluation",
"statusUsableDate" : "2021-04-29",
"briefResultsDescription" : "Holding DOAC by this protocol has little bleeding and events",
"published" : "2019-08-05",
"pageName" : "PAUSE",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "PAUSE",
"title" : "Perioperative management of patients with atrial fibrillation receiving a direct oral anticoagulant",
"pmid" : "31380891"
},
{
"timestamp" : "2017-12-03T22:38:13Z",
"briefDesignDescription" : "Finasteride for prostate cancer prophylaxis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030660",
"pageid" : 1786,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030660",
"trainingLevel" : "Intern",
"citation" : "Thompson IM, et al. \"The influence of finasteride on the development of prostate cancer\". The New England Journal of Medicine. 2003. 349(3):215-224.",
"subspecialties" : "Urology;Oncology",
"expansion" : "Prostate Cancer Prevention Trial",
"statusUsableDate" : "2014-02-01",
"briefResultsDescription" : "Finasteride reduces all-grade prostate cancer risk, increases high-grade disease",
"published" : "2003-07-13",
"pageName" : "PCPT",
"diseases" : "Prostate Cancer",
"abbreviation" : "PCPT",
"title" : "The influence of finasteride on the development of prostate cancer",
"pmid" : "12824459"
},
{
"timestamp" : "2020-09-14T19:27:22Z",
"briefDesignDescription" : "Extended ticagrelor+ASA after MI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500857",
"pageid" : 2469,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500857",
"trainingLevel" : "Intern",
"citation" : "Bonaca MP, et al. \"Long-term use of ticagrelor in patients with prior myocardial infarction\". The New England Journal of Medicine. 2015. 372(19):1791-1800.",
"subspecialties" : "Cardiology",
"expansion" : "",
"statusUsableDate" : "2015-12-01",
"briefResultsDescription" : "Extended ticagrelor+ASA reduces CVD events after MI",
"published" : "2015-05-07",
"pageName" : "PEGASUS-TIMI 54",
"diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "PEGASUS-TIMI 54",
"title" : "Long-term use of ticagrelor in patients with prior myocardial infarction",
"pmid" : "25773268"
},
{
"timestamp" : "2021-06-08T19:31:33Z",
"briefDesignDescription" : "tPA for submassive PE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1302097",
"pageid" : 1778,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302097",
"trainingLevel" : "resident",
"citation" : "Meyer G, et al. \"Fibrinolysis for patients with intermediate-risk pulmonary embolism\". The New England Journal of Medicine. 2014. 370(15):1402-1411.",
"subspecialties" : "Critical Care;Pulmonology;Hematology",
"expansion" : "Pulmonary Embolism Thrombolysis trial",
"statusUsableDate" : "2014-04-01",
"briefResultsDescription" : "tPA reduces hemodynamic decomp, not mortality, also increases bleeding in submassive PE",
"published" : "2014-04-10",
"pageName" : "PEITHO",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "PEITHO",
"title" : "Fibrinolysis for patients with intermediate-risk pulmonary embolism",
"pmid" : "24716681"
},
{
"timestamp" : "2015-07-06T21:57:52Z",
"briefDesignDescription" : "Pentoxifylline in alcoholic hepatitis",
"fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(00)51183-4/fulltext",
"pageid" : 53,
"pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0016-5085/PIIS0016508500511834.pdf",
"trainingLevel" : "Resident",
"citation" : "Akriviadis E, et al. \"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial\". Gastroenterology. 2000. 119(6):1637-48.",
"subspecialties" : "Gastroenterology",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis",
"published" : "2000-12-20",
"pageName" : "Pentoxifylline in Severe Alcoholic Hepatitis",
"diseases" : "Alcoholic Hepatitis",
"abbreviation" : "",
"title" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial",
"pmid" : "11113085"
},
{
"timestamp" : "2021-05-31T17:58:55Z",
"briefDesignDescription" : "PE rule-out criteria",
"fulltexturl" : "http://dx.doi.org/10.1111/j.1538-7836.2008.02944.x",
"pageid" : 2657,
"pdfurl" : "http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2008.02944.x/epdf",
"trainingLevel" : "Resident",
"citation" : "Kline JA, et al. \"Prospective multicenter evaluation of the pulmonary embolism rule-out criteria\". J Thromb Haemost. 2008. 6(5):772-780.",
"subspecialties" : "Emergency Medicine;Pulmonology;Hematology",
"expansion" : "Pulmonary Embolism Rule-Out Criteria",
"statusUsableDate" : "2021-05-20",
"briefResultsDescription" : "Low probability of PE mortality with low PERC probability",
"published" : "2008-05-06",
"pageName" : "PERC",
"diseases" : "Pulmonary Embolism",
"abbreviation" : "PERC",
"title" : "Prospective multicenter evaluation of the pulmonary embolism rule-out criteria",
"pmid" : "18318689"
},
{
"timestamp" : "2017-12-03T22:38:18Z",
"briefDesignDescription" : "Prevalence of PE in syncope",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602172",
"pageid" : 2843,
"pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602172",
"trainingLevel" : "Resident",
"citation" : "Prandoni P, et al. \"Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope\". The New England Journal of Medicine. 2016. 375(16):1524-31.",
"subspecialties" : "Hematology",
"expansion" : "Pulmonary Embolism in Syncope Italian Trial",
"statusUsableDate" : "2016-11-01",
"briefResultsDescription" : "PE found in 1 of 6 patients with syncope",
"published" : "2016-10-20",
"pageName" : "PESIT",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism;Syncope",
"abbreviation" : "PESIT",
"title" : "Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope",
"pmid" : "27797317"
},
{
"timestamp" : "2017-12-03T22:38:19Z",
"briefDesignDescription" : "DOAC, VKA, antiplatelets after PCI with stent",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611594",
"pageid" : 2861,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611594",
"trainingLevel" : "Resident",
"citation" : "Gibson CM, et al. \"Prevention of bleeding in patients with AF undergoing PCI\". The New England Journal of Medicine. 2016. epub 2016-11-14:1-12.",
"subspecialties" : "Cardiology",
"expansion" : "Open-Label, Randomized, Controlled, Multicenter Study Exploring Two Treatment Strategies of Rivaroxaban and a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy in Subjects with AF who Undergo Percutaneous Coronary Intervention",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "Rivaroxaban with lower bleeding",
"published" : "2016-11-14",
"pageName" : "PIONEER AF-PCI",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"abbreviation" : "PIONEER AF-PCI",
"title" : "Prevention of bleeding in patients with AF undergoing PCI",
"pmid" : "27959713"
},
{
"timestamp" : "2019-02-14T22:49:17Z",
"briefDesignDescription" : "ARNI started in ADHF hospitalization",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812851",
"pageid" : 3740,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812851",
"trainingLevel" : "Student",
"citation" : "Velazquez EJ, et al. \"Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure\". The New England Journal of Medicine. 2018. ePub 2018-11-11:1-10.",
"subspecialties" : "Cardiology",
"expansion" : "comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode",
"statusUsableDate" : "2019-01-31",
"briefResultsDescription" : "Sacubitril-valsartan reduces NT-ProBNP",
"published" : "2018-11-11",
"pageName" : "PIONEER-HF",
"diseases" : "Heart Failure",
"abbreviation" : "PIONEER-HF",
"title" : "Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure",
"pmid" : "30415601"
},
{
"timestamp" : "2016-04-05T13:46:19Z",
"briefDesignDescription" : "Accuracy of CT for PE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052367#t",
"pageid" : 161,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052367#t",
"trainingLevel" : "MedicalStudent",
"citation" : "Stein PD, et al. \"Multidetector Computed Tomography for Acute Pulmonary Embolism\". The New England Journal of Medicine. 2006. 354(22):2317-2327.",
"subspecialties" : "Pulmonology;Hematology",
"expansion" : "Prospective Investigation of Pulmonary Embolism Diagnosis II",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "CT sensitive and specific in detecting acute PE",
"published" : "2006-06-01",
"pageName" : "PIOPED II",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "PIOPED II",
"title" : "Multidetector Computed Tomography for Acute Pulmonary Embolism",
"pmid" : "16738268"
},
{
"timestamp" : "2019-12-20T10:41:43Z",
"briefDesignDescription" : "Probiotics to prevent CDAD",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2961218-0/abstract",
"pageid" : 1770,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673613612180.pdf",
"trainingLevel" : "Resident",
"citation" : "Allen SJ, et al. \"Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial\". The Lancet. 2013. 382(9900):1249-1257.",
"subspecialties" : "Gastroenterology;Infectious Disease;Preventive Medicine",
"expansion" : "",
"statusUsableDate" : "2014-05-01",
"briefResultsDescription" : "Probiotics do not reduce diarrhea including C. diff with antibiotics",
"published" : "2013-10-12",
"pageName" : "PLACIDE",
"diseases" : "Clostridium difficile",
"abbreviation" : "PLACIDE",
"title" : "Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial",
"pmid" : "23932219"
},
{
"timestamp" : "2017-12-03T22:38:22Z",
"briefDesignDescription" : "Ticagrelor vs. clopidogrel in ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0904327",
"pageid" : 1629,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0904327",
"trainingLevel" : "Resident",
"citation" : "Wallentin L, et al. \"Ticagrelor versus clopidogrel in patients with acute coronary syndromes\". The New England Journal of Medicine. 2009. 361(11):1045-1057.",
"subspecialties" : "Cardiology",
"expansion" : "Platelet Inhibition and Patient Outcomes",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "Ticagrelor reduces mortality, increases bleeding",
"published" : "2009-09-10",
"pageName" : "PLATO",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease",
"abbreviation" : "PLATO",
"title" : "Ticagrelor versus clopidogrel in patients with acute coronary syndromes",
"pmid" : "19717846"
},
{
"timestamp" : "2012-05-07T02:36:42Z",
"briefDesignDescription" : "8 vs. 15 days of antibiotics in VAP",
"fulltexturl" : "http://jama.ama-assn.org/content/290/19/2588.long",
"pageid" : 118,
"pdfurl" : "http://jama.ama-assn.org/content/290/19/2588.full.pdf",
"trainingLevel" : "Intern",
"citation" : "Chastre J. \"Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial\". Journal of the American Medical Association. 2003. 290(19):2588-98.",
"subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "8 days of antibiotics are equivalent to 15 days",
"published" : "2003-11-19",
"pageName" : "PneumA",
"diseases" : "Pneumonia",
"abbreviation" : "PneumA",
"title" : "Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial",
"pmid" : "14625336"
},
{
"timestamp" : "2019-08-26T14:27:41Z",
"briefDesignDescription" : "PO abx after 10d IV abx for left-sided endocarditis",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1808312",
"pageid" : 3722,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1808312",
"trainingLevel" : "Student",
"citation" : "Iversen K, et al. \"Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis\". The New England Journal of Medicine. 2019. 380(5):415-424.",
"subspecialties" : "Infectious Disease",
"expansion" : "Partial Oral Treatment of Endocarditis",
"statusUsableDate" : "2019-04-10",
"briefResultsDescription" : "PO abx after IV abx non-inferior to IV abx only",
"published" : "2019-01-31",
"pageName" : "POET",
"diseases" : "Endocarditis",
"abbreviation" : "POET",
"title" : "Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis",
"pmid" : "30152252"
},
{
"timestamp" : "2018-11-07T06:34:44Z",
"briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin in stroke/TIA",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800410",
"pageid" : 3659,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800410",
"trainingLevel" : "Resident",
"citation" : "Johnston SC, et al. \"Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA\". The New England Journal of Medicine. 2018. 379(3):215-225.",
"subspecialties" : "Neurology",
"expansion" : "Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial",
"statusUsableDate" : "2018-08-09",
"briefResultsDescription" : "Aspirin/clopidogrel reduces stroke recurrence, increases bleeding compared to aspirin",
"published" : "2018-05-16",
"pageName" : "POINT",
"diseases" : "Stroke;Transient Ischemic Attack",
"abbreviation" : "POINT",
"title" : "Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA",
"pmid" : "29766750"
},
{
"timestamp" : "2023-05-03T15:50:32Z",
"briefDesignDescription" : "Perioperative metoprolol",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)60601-7/fulltext",
"pageid" : 173,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673608606017.pdf",
"trainingLevel" : "Intern",
"citation" : "Devereaux PJ, et al. \"Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial\". The Lancet. 2008. 371(9627):1839-1847.",
"subspecialties" : "Surgery;Cardiology",
"expansion" : "PeriOperative ISchemic Evaluation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Perioperative metoprolol reduces MI risk but increases risk of mortality and stroke",
"published" : "2008-05-31",
"pageName" : "POISE",
"diseases" : "Cardiac Risk Assessment;Coronary Artery Disease",
"abbreviation" : "POISE",
"title" : "Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial",
"pmid" : "18479744"
},
{
"timestamp" : "2017-12-03T22:38:24Z",
"briefDesignDescription" : "Perioperative ASA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1401105",
"pageid" : 1777,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1401105",
"trainingLevel" : "Intern",
"citation" : "Devereaux PJ, et al. \"Aspirin in patients undergoing noncardiac surgery\". The New England Journal of Medicine. 2014. 370(16):1494-1503.",
"subspecialties" : "Cardiology;Surgery",
"expansion" : "Perioperative ischemic evaluation 2 aspirin arm",
"statusUsableDate" : "2014-04-01",
"briefResultsDescription" : "Perioperative ASA doesn't modify MI rates but increases major bleeding",
"published" : "2014-03-31",
"pageName" : "POISE-2 ASA",
"diseases" : "Cardiac Risk Assessment",
"abbreviation" : "POISE-2 ASA",
"title" : "Aspirin in patients undergoing noncardiac surgery",
"pmid" : "24679062"
},
{
"timestamp" : "2017-12-03T22:38:25Z",
"briefDesignDescription" : "PPIs for stress ulcer prophylaxis",
"fulltexturl" : "https://dx.doi.org/10.1097/CCM.0000000000001819",
"pageid" : 2866,
"pdfurl" : "http://ovidsp.tx.ovid.com/sp-3.26.1a/ovidweb.cgi?&S",
"trainingLevel" : "Resident",
"citation" : "Selvanderan SP, et al. \"Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study\". Critical Care Medicine. 2016. 44(10):1842-1850.",
"subspecialties" : "Critical Care",
"expansion" : "Pantoprazole or Placebo for Stress Ulcer Prophylaxis",
"statusUsableDate" : "2017-09-01",
"briefResultsDescription" : "PPIs do not reduce risk of stress ulcer bleeding in enterally fed patients",
"published" : "2016-10-01",
"pageName" : "POP-UP",
"diseases" : "Stress Ulcer",
"abbreviation" : "POP-UP",
"title" : "Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study",
"pmid" : "27635481"
},
{
"timestamp" : "2021-01-11T18:51:08Z",
"briefDesignDescription" : "Transvenous vs. subq ICD to prevent sudden cardiac death",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1915932",
"pageid" : 4394,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915932",
"trainingLevel" : "Resident",
"citation" : "Knops RE, et al. \"Subcutaneous or Transvenous Defibrillator Therapy\". The New England Journal of Medicine. 2020. 383(6):526-36.",
"subspecialties" : "Cardiology",
"expansion" : "Prospective Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy",
"statusUsableDate" : "2021-01-08",
"briefResultsDescription" : "Subcutaneous ICD non-inferior to transvenous ICD",
"published" : "2020-08-06",
"pageName" : "PRAETORIAN",
"diseases" : "Unstable Arrhythmia",
"abbreviation" : "PRAETORIAN",
"title" : "Subcutaneous or Transvenous Defibrillator Therapy",
"pmid" : "32757521"
},
{
"timestamp" : "2018-11-18T20:26:21Z",
"briefDesignDescription" : "PCI to high-risk non-infarct arteries in STEMI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305520",
"pageid" : 1748,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1305520",
"trainingLevel" : "Resident",
"citation" : "Wald DS, et al. \"Randomized trial of preventative angioplasty in myocardial infarction\". The New England Journal of Medicine. 2013. 369(12):1115-1123.",
"subspecialties" : "Cardiology",
"expansion" : "Preventative Angioplasty in Acute Myocardial Infarction",
"statusUsableDate" : "2013-11-01",
"briefResultsDescription" : "PCI to high-risk non infarct arteries in STEMI improves CV outcomes",
"published" : "2013-09-19",
"pageName" : "PRAMI",
"diseases" : "Myocardial Infarction",
"abbreviation" : "PRAMI",
"title" : "Randomized trial of preventative angioplasty in myocardial infarction",
"pmid" : "23991625"
},
{
"timestamp" : "2018-06-01T20:19:38Z",
"briefDesignDescription" : "Celecoxib, naproxen, or ibuprofen for CV safety in arthritis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611593",
"pageid" : 2888,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611593",
"trainingLevel" : "Resident",
"citation" : "Nissen SE, et al. \"Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis\". The New England Journal of Medicine. 2016. 375(26):2519-2529.",
"subspecialties" : "Cardiology;Rheumatology;Neurology",
"expansion" : "Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen",
"statusUsableDate" : "2017-03-01",
"briefResultsDescription" : "Celecoxib noninferior to ibuprofen or naproxen with regard to CV safety",
"published" : "2016-12-29",
"pageName" : "PRECISION",
"diseases" : "Coronary Artery Disease;Rheumatoid Arthritis;Osteoarthritis;Stroke",
"abbreviation" : "PRECISION",
"title" : "Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis",
"pmid" : "27959716"
},
{
"timestamp" : "2018-06-14T20:17:40Z",
"briefDesignDescription" : "Mediterranean diet in CVD prevention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200303",
"pageid" : 1247,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200303",
"trainingLevel" : "Student",
"citation" : "Estruch R, et al. \"Primary prevention of cardiovascular disease with a mediterranean diet\". The New England Journal of Medicine. 2013. 368(14):1279-1290.",
"subspecialties" : "Cardiology",
"expansion" : "Prevención con Dieta Mediterránea",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Mediterranean diet reduces composite rate of MI/CVA/CV death",
"published" : "2013-02-25",
"pageName" : "PREDIMED",
"diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
"abbreviation" : "PREDIMED",
"title" : "Primary prevention of cardiovascular disease with a mediterranean diet",
"pmid" : "23432189"
},
{
"timestamp" : "2015-07-06T21:57:28Z",
"briefDesignDescription" : "Prednisolone vs. placebo in alcoholic hepatitis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199202203260802",
"pageid" : 1113,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199202203260802",
"trainingLevel" : "Intern",
"citation" : "Ramond MJ, et al. \"A randomized trial of prednisolone in patients with severe alcoholic hepatitis\". The New England Journal of Medicine. 1992. 362(8):507-512.",
"subspecialties" : "Gastroenterology",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Prednisolone improves short-term survival",
"published" : "1992-02-20",
"pageName" : "Prednisolone in Severe Alcoholic Hepatitis",
"diseases" : "Alcoholic Hepatitis",
"abbreviation" : "",
"title" : "A randomized trial of prednisolone in patients with severe alcoholic hepatitis",
"pmid" : "1531090"
},
{
"timestamp" : "2017-12-03T22:38:31Z",
"briefDesignDescription" : "IVC filters for proximal DVT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199802123380701",
"pageid" : 2697,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199802123380701",
"trainingLevel" : "Resident",
"citation" : "Decousus H, et al. \"A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis\". The New England Journal of Medicine. 1998. 338(7):409-416.",
"subspecialties" : "Pulmonology;Hematology;Interventional Radiology",
"expansion" : "Prévention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group",
"statusUsableDate" : "2016-03-01",
"briefResultsDescription" : "IVC filters reduce future PE risk but increase DVT risk",
"published" : "1998-02-12",
"pageName" : "PREPIC",
"diseases" : "Deep Vein Thrombosis;Venous Thromboembolism;Pulmonary Embolism",
"abbreviation" : "PREPIC",
"title" : "A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis",
"pmid" : "9459643"
},
{
"timestamp" : "2017-12-03T22:38:33Z",
"briefDesignDescription" : "IVC filters for high-risk PE",
"fulltexturl" : "http://bit.ly/1Jti6Ct",
"pageid" : 2405,
"pdfurl" : "http://bit.ly/1ONs0iA",
"trainingLevel" : "Intern",
"citation" : "Mismetti P, et al. \"Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial\". The Journal of the American Medical Association. 2015. 313(16):1627-35.",
"subspecialties" : "Hematology;Pulmonology;Interventional Radiology",
"expansion" : "Prevention du Risque d'Embolie Pulmonaire par Interruption Cave 2",
"statusUsableDate" : "2015-07-01",
"briefResultsDescription" : "IVC filters do not improve outcomes in acute high-risk PE",
"published" : "2015-04-28",
"pageName" : "PREPIC 2",
"diseases" : "Venous Thromboembolism",
"abbreviation" : "PREPIC 2",
"title" : "Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial",
"pmid" : "25919526"
},
{
"timestamp" : "2021-07-30T04:27:31Z",
"briefDesignDescription" : "LAA closure vs. warfarin in AF",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(14)02341-9",
"pageid" : 3535,
"pdfurl" : "https://www.sciencedirect.com/science/article/pii/S0735109714023419/pdfft?download",
"trainingLevel" : "Resident",
"citation" : "Holmes DR, et al. \"Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial\". Journal of the American College of Cardiology. 2014. 64(1):1-12.",
"subspecialties" : "Cardiology",
"expansion" : "Prospective Randomized Evaluation of the Watchman LAA Closure Device In Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy",
"statusUsableDate" : "2021-07-29",
"briefResultsDescription" : "LAA noninferior to warfarin in AF",
"published" : "2014-07-08",
"pageName" : "PREVAIL",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "PREVAIL",
"title" : "Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial",
"pmid" : "24998121"
},
{
"timestamp" : "2017-12-03T22:38:34Z",
"briefDesignDescription" : "Rifapentine/isoniazid in latent TB",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1104875",
"pageid" : 928,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1104875",
"trainingLevel" : "fellow",
"citation" : "Sterling TR, et al. \"Three months of rifapentine and isoniazid for latent tuberculosis infection.\". The New England Journal of Medicine. 2011. 365(23):2155-66.",
"subspecialties" : "Infectious Disease",
"expansion" : null,
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Rifapentine/isoniazid x3 months is noninferior to isoniazid x9 months",
"published" : "2011-12-08",
"pageName" : "PREVENT TB",
"diseases" : "Tuberculosis",
"abbreviation" : "PREVENT TB",
"title" : "Three months of rifapentine and isoniazid for latent tuberculosis infection.",
"pmid" : "22150035"
},
{
"timestamp" : "2017-12-03T22:38:46Z",
"briefDesignDescription" : "EGDT in septic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1401602",
"pageid" : 1782,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1401602",
"trainingLevel" : "Intern",
"citation" : "Angus DC, et al. \"A randomized trial of protocol-based care for early septic shock\". The New England Journal of Medicine. 2014. 370(10):1683-1693.",
"subspecialties" : "Critical Care",
"expansion" : "Protocolized Care for Early Septic Shock",
"statusUsableDate" : "2014-03-01",
"briefResultsDescription" : "No difference for EGDT vs. standard protocol vs. usual care for septic shock",
"published" : "2014-05-01",
"pageName" : "ProCESS",
"diseases" : "Sepsis",
"abbreviation" : "ProCESS",
"title" : "A randomized trial of protocol-based care for early septic shock",
"pmid" : "24635773"
},
{
"timestamp" : "2017-12-03T22:38:35Z",
"briefDesignDescription" : "FOLFIRINOX in pancreatic cancer",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011923",
"pageid" : 2819,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011923",
"trainingLevel" : "Resident",
"citation" : "Conroy T, et al. \"FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer\". The New England Journal of Medicine. 2011. 364(19):1817-1825.",
"subspecialties" : "Oncology",
"expansion" : "PRODIGE 4 Actions concertées dans les Cancers COloRectaux et Digestifs",
"statusUsableDate" : "2016-09-01",
"briefResultsDescription" : "FOLFIRINOX improves OS in metastatic pancreatic cancer compared to gemcitabine",
"published" : "2011-05-12",
"pageName" : "PRODIGE 4 ACCORD 11",
"diseases" : "Pancreatic Cancer",
"abbreviation" : "PRODIGE 4 ACCORD 11",
"title" : "FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer",
"pmid" : "21561347"
},
{
"timestamp" : "2017-12-03T22:38:44Z",
"briefDesignDescription" : "ASA-dipyridamole vs. clopidogrel in stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805002",
"pageid" : 1082,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805002",
"trainingLevel" : "Resident",
"citation" : "Sacco RL, et al. \"Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke\". The New England Journal of Medicine. 2008. 359(12):1238-1251.",
"subspecialties" : "Neurology",
"expansion" : "Prevention Regimen for Effectively Avoiding Second Strokes",
"statusUsableDate" : "2012-11-01",
"briefResultsDescription" : "Similar efficacy but less bleeding with clopidogrel",
"published" : "2008-09-18",
"pageName" : "PRoFESS",
"diseases" : "Stroke",
"abbreviation" : "PROFESS",
"title" : "Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke",
"pmid" : "18753638"
},
{
"timestamp" : "2023-07-20T03:15:45Z",
"briefDesignDescription" : "Perindopril±indapamide after stroke",
"fulltexturl" : "https://doi.org/10.1016/S0140-6736(01)06178-5",
"pageid" : 2450,
"pdfurl" : "",
"trainingLevel" : "Intern",
"citation" : "PROGRESS Collaborative Group. \"Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack\". Lancet. 2001. 358(9287):1033–1041.",
"subspecialties" : "Neurology",
"expansion" : "Protection Against Recurrent Stroke Study",
"statusUsableDate" : "2023-01-21",
"briefResultsDescription" : "Perindopril+indapamide lowers recurrent stroke risk among those with prior stroke",
"published" : "2001-09-29",
"pageName" : "PROGRESS",
"diseases" : "Stroke;Hypertension",
"abbreviation" : "PROGRESS",
"title" : "Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack",
"pmid" : "11589932"
},
{
"timestamp" : "2017-12-03T22:38:37Z",
"briefDesignDescription" : "D-Dimer testing after VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa054444",
"pageid" : 2967,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa054444",
"trainingLevel" : "Resident",
"citation" : "Palareti G, et al. \"d-Dimer Testing to Determine the Duration of Anticoagulation Therapy\". The New England Journal of Medicine. 2006. 355(17):1780-1789.",
"subspecialties" : "Hematology",
"expansion" : "",
"statusUsableDate" : "2017-10-01",
"briefResultsDescription" : "Abnormal D-dimer predicts VTE recurrence",
"published" : "2006-10-26",
"pageName" : "PROLONG",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"abbreviation" : "PROLONG",
"title" : "d-Dimer Testing to Determine the Duration of Anticoagulation Therapy",
"pmid" : "17065639"
},
{
"timestamp" : "2019-02-28T18:12:36Z",
"briefDesignDescription" : "Multicenter EGDT trial in severe sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500896",
"pageid" : 2385,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500896",
"trainingLevel" : "Resident",
"citation" : "Mouncey PR, et al. \"Trial of early, goal-directed resuscitation for septic shock\". The New England Journal of Medicine. 2015. 372(14):1301-1311.",
"subspecialties" : "Critical Care;Emergency Medicine",
"expansion" : "",
"statusUsableDate" : "2019-02-27",
"briefResultsDescription" : "Multicenter trial shows no benefit to EGDT in severe sepsis",
"published" : "2015-04-02",
"pageName" : "ProMISe",
"diseases" : "Sepsis;Shock",
"abbreviation" : "ProMISe",
"title" : "Trial of early, goal-directed resuscitation for septic shock",
"pmid" : "25776532"
},
{
"timestamp" : "2023-04-21T16:19:29Z",
"briefDesignDescription" : "Validation of PERC score in PE",
"fulltexturl" : "https://jamanetwork.com/journals/jama/article-abstract/2672630",
"pageid" : 3548,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Freund Y, et al. \"Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial\". Journal of the American Medical Association. 2018. 319(6):559-566.",
"subspecialties" : "Emergency Medicine",
"expansion" : "Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients",
"statusUsableDate" : "2023-04-20",
"briefResultsDescription" : "PERC score excludes PE in low-risk patients",
"published" : "2018-02-13",
"pageName" : "PROPER",
"diseases" : "Pulmonary Embolism",
"abbreviation" : "PROPER",
"title" : "Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial",
"pmid" : "29450523"
},
{
"timestamp" : "2023-09-28T19:19:28Z",
"briefDesignDescription" : "Transfusion ratios in hemorrhagic shock",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2107789",
"pageid" : 2504,
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/2107789/joi150002.pdf",
"trainingLevel" : "Resident",
"citation" : "Holcomb JB, et al. \"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial\". JAMA. 2015. 313(5):471-482.",
"subspecialties" : "Emergency Medicine;Critical Care;Hematology",
"expansion" : "Pragmatic, Randomized Optimal Platelet and Plasma Ratios",
"statusUsableDate" : "2023-09-28",
"briefResultsDescription" : "1:1:1 ratio of FFP:PLT:RBC no better than 1:1:2",
"published" : "2015-02-03",
"pageName" : "PROPPR",
"diseases" : "Hemorrhage;Trauma;Shock",
"abbreviation" : "PROPPR",
"title" : "Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial",
"pmid" : "25647203"
},
{
"timestamp" : "2017-08-06T02:15:05Z",
"briefDesignDescription" : "Procalcitonin-guided antibiotics",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61879-1/fulltext",
"pageid" : 434,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673609618791.pdf",
"trainingLevel" : "resident",
"citation" : "Bouadma L, et al. \"Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units\". The Lancet. 2010. 375(9713):463-74.",
"subspecialties" : "Critical Care;Infectious Disease",
"expansion" : "Procalcitonin to Reduce Antibiotic Treatments in Acutely ill patients",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Procalcitonin noninferior and led to fewer days on antibiotics",
"published" : "2010-02-06",
"pageName" : "PRORATA",
"diseases" : "Critical Illness",
"abbreviation" : "PRORATA",
"title" : "Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units",
"pmid" : "20097417"
},
{
"timestamp" : "2020-11-12T18:32:26Z",
"briefDesignDescription" : "Prone ventilation in ARDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1214103",
"pageid" : 1479,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214103",
"trainingLevel" : "fellow",
"citation" : "Guérin C, et al. \"Prone positioning in severe acute respiratory distress syndrome\". The New England Journal of Medicine. 2013. 368(23):2159-2168.",
"subspecialties" : "Critical Care",
"expansion" : "Proning Severe ARDS Patients",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Intermittent prone positioning improves survival in severe ARDS",
"published" : "2013-06-06",
"pageName" : "PROSEVA",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "PROSEVA",
"title" : "Prone positioning in severe acute respiratory distress syndrome",
"pmid" : "23688302"
},
{
"timestamp" : "2021-07-30T09:17:37Z",
"briefDesignDescription" : "LAA closure vs. warfarin in AF",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61343-X/fulltext",
"pageid" : 2459,
"pdfurl" : "",
"trainingLevel" : "Intern",
"citation" : "Holmes DR, et al. \"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial\". Lancet. 2009. 374(9689):534-42.",
"subspecialties" : "Cardiology",
"expansion" : "WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation",
"statusUsableDate" : "2018-01-18",
"briefResultsDescription" : "LAA closure was noninferior to warfarin therapy",
"published" : "2009-11-07",
"pageName" : "PROTECT AF",
"diseases" : "Atrial Fibrillation;Stroke",
"abbreviation" : "PROTECT AF",
"title" : "Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial",
"pmid" : "19683639"
},
{
"timestamp" : "2017-12-14T19:39:45Z",
"briefDesignDescription" : "Pravastatin vs. atorvastatin after ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040583",
"pageid" : 1338,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040583",
"trainingLevel" : "Intern",
"citation" : "Cannon CP, et al. \"Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes\". The New England Journal of Medicine. 2004. 350(15):1495-1504.",
"subspecialties" : "Cardiology",
"expansion" : "Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "High-dose atorvastatin is superior to moderate-dose pravastatin at reducing CV events after ACS",
"published" : "2004-04-08",
"pageName" : "PROVE IT-TIMI 22",
"diseases" : "Acute Coronary Syndrome;Hyperlipidemia",
"abbreviation" : "PROVE IT-TIMI 22",
"title" : "Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes",
"pmid" : "15007110"
},
{
"timestamp" : "2017-12-03T22:38:41Z",
"briefDesignDescription" : "Activated protein C in severe sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200103083441001",
"pageid" : 983,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200103083441001",
"trainingLevel" : "Resident",
"citation" : "Bernard GR, et al. \"Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis\". The New England Journal of Medicine. 2001. 344(10):699-709.",
"subspecialties" : "Critical Care",
"expansion" : "Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis",
"statusUsableDate" : "2012-09-01",
"briefResultsDescription" : "Improved survival with APC but not seen in subsequent larger PROWESS-SHOCK trial",
"published" : "2001-03-08",
"pageName" : "PROWESS",
"diseases" : "Sepsis;Shock",
"abbreviation" : "PROWESS",
"title" : "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis",
"pmid" : "11236773"
},
{
"timestamp" : "2017-12-03T22:38:43Z",
"briefDesignDescription" : "Activated protein C in septic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1202290",
"pageid" : 977,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1202290",
"trainingLevel" : "Resident",
"citation" : "Ranieri VM, et al. \"Drotrecogin Alfa (Activated) in Adults with Septic Shock\". The New England Journal of Medicine. 2012. 366(22):2055-2064.",
"subspecialties" : "Critical Care",
"expansion" : "Prospective Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis and Septic Shock",
"statusUsableDate" : "2012-09-01",
"briefResultsDescription" : "No survival benefit at 28 or 90 days, in contrast to PROWESS",
"published" : "2012-05-31",
"pageName" : "PROWESS-SHOCK",
"diseases" : "Sepsis;Shock",
"abbreviation" : "PROWESS-SHOCK",
"title" : "Drotrecogin Alfa (Activated) in Adults with Septic Shock",
"pmid" : "22616830"
},
{
"timestamp" : "2018-12-24T16:50:42Z",
"briefDesignDescription" : "Basal-bolus insulin in inpatients with DM",
"fulltexturl" : "http://bit.ly/29xvPia",
"pageid" : 2720,
"pdfurl" : "http://care.diabetesjournals.org/content/30/9/2181.full-text.pdf",
"trainingLevel" : "Intern",
"citation" : "Umpierrez GE, et al. \"Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)\". Diabetes Care. 2007. 30(9):2181-2186.",
"subspecialties" : "Critical Care;Endocrinology",
"expansion" : "Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes",
"statusUsableDate" : "2018-06-14",
"briefResultsDescription" : "Basal-bolus more effective for glycemic control compared to sliding-scale insulin",
"published" : "2007-09-30",
"pageName" : "RABBIT 2",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "RABBIT 2",
"title" : "Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)",
"pmid" : "17513708"
},
{
"timestamp" : "2014-05-22T00:30:05Z",
"briefDesignDescription" : "Lenient vs. strict rate control in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001337",
"pageid" : 181,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001337",
"trainingLevel" : "Resident",
"citation" : "Van Gelder IC, et al. \"Lenient versus Strict Rate Control in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2010. 362(15):1363-73.",
"subspecialties" : "Cardiology",
"expansion" : "Rate Control Efficacy in Permanent Atrial Fibrillation: a Comparison between Lenient versus Strict Rate Control II",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Lenient rate control is as effective as strict rate control",
"published" : "2010-04-15",
"pageName" : "RACE II",
"diseases" : "Atrial Fibrillation",
"abbreviation" : "RACE II",
"title" : "Lenient versus Strict Rate Control in Patients with Atrial Fibrillation",
"pmid" : "20231232"
},
{
"timestamp" : "2019-04-18T17:47:41Z",
"briefDesignDescription" : "Radiograph vs. MRI for low back pain",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/196680",
"pageid" : 2665,
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/196680/joc22401.pdf",
"trainingLevel" : "Intern",
"citation" : "Jarvik JG, et al. \"Rapid magnetic resonance imaging vs. radiographs for patients with low back pain: a randomized controlled trial.\". The Journal of the American Medical Association. 2003. 289(21):2810-8.",
"subspecialties" : "Physical Medicine and Rehabilitation",
"expansion" : "",
"statusUsableDate" : "2018-10-31",
"briefResultsDescription" : "No differences in pain or disability related to back pain, possibly more surgeries in MRI group",
"published" : "2003-06-04",
"pageName" : "Radiograph vs. MRI for low back pain",
"diseases" : "Low back pain",
"abbreviation" : "Radiograph vs. MRI for low back pain",
"title" : "Rapid magnetic resonance imaging vs. radiographs for patients with low back pain: a randomized controlled trial.",
"pmid" : "12783911"
},
{
"timestamp" : "2017-12-03T22:38:47Z",
"briefDesignDescription" : "CRT+ICD for mild-moderate HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009540",
"pageid" : 2731,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009540",
"trainingLevel" : "Resident",
"citation" : "Tang AS, et al. \"Cardiac-resynchronization therapy for mild-to-moderate heart failure\". The New England Journal of Medicine. 2010. 363(25):2385-2395.",
"subspecialties" : "Cardiology",
"expansion" : "Resynchronization–Defibrillation for Ambulatory Heart Failure",
"statusUsableDate" : "2016-09-01",
"briefResultsDescription" : "CRT+ICD reduces mortality but increased the rate of adverse events",
"published" : "2010-12-16",
"pageName" : "RAFT",
"diseases" : "Heart Failure",
"abbreviation" : "RAFT",
"title" : "Cardiac-resynchronization therapy for mild-to-moderate heart failure",
"pmid" : "21073365"
},
{
"timestamp" : "2015-08-24T04:40:44Z",
"briefDesignDescription" : "Spironolactone in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199909023411001",
"pageid" : 11,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199909023411001",
"trainingLevel" : "Intern",
"citation" : "Pitt B, et al. \"The effect of spironolactone on morbidity and mortality in patients with severe heart failure\". New England Journal of Medicine. 1999. 341(10):709-717.",
"subspecialties" : "Cardiology",
"expansion" : "Randomized Aldactone Evaluation Study",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Spironolactone reduces all-cause mortality by 30% in severe HFrEF",
"published" : "1999-09-02",
"pageName" : "RALES",
"diseases" : "Heart Failure",
"abbreviation" : "RALES",
"title" : "The effect of spironolactone on morbidity and mortality in patients with severe heart failure",
"pmid" : "10471456"
},
{
"timestamp" : "2021-08-12T22:54:12Z",
"briefDesignDescription" : "Midazolam vs. lorazepam for status epilepticus",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1107494",
"pageid" : 2505,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1107494",
"trainingLevel" : "Intern",
"citation" : "Silbergleit R, et al. \"Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus\". The New England Journal of Medicine. 2012. 366(7):591-600.",
"subspecialties" : "Neurology",
"expansion" : "Rapid Anticonvulsant Medication Prior to Arrival Trial",
"statusUsableDate" : "2019-08-31",
"briefResultsDescription" : "IM midazolam is as safe and efficacious as IV lorazepam",
"published" : "2012-02-22",
"pageName" : "RAMPART",
"diseases" : "Epilepsy;Seizure",
"abbreviation" : "RAMPART",
"title" : "Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus",
"pmid" : "22335736"
},
{
"timestamp" : "2017-12-03T22:38:49Z",
"briefDesignDescription" : "Rituximab vs. cyclophosphamide in ANCA-associated vasculitis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909905",
"pageid" : 1214,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909905",
"trainingLevel" : "Fellow",
"citation" : "Stone JH, et al. \"Rituximab versus cyclophosphamide for ANCA-associated vasculitis\". The New England Journal of Medicine. 2010. 363(3):221-232.",
"subspecialties" : "Rheumatology",
"expansion" : "Rituximab in ANCA-Associated Vasculitis",
"statusUsableDate" : "2013-02-01",
"briefResultsDescription" : "Rituximab noninferior to cyclophosphamide in ANCA-associated vasculitis",
"published" : "2010-07-15",
"pageName" : "RAVE",
"diseases" : "Vasculitis",
"abbreviation" : "RAVE",
"title" : "Rituximab versus cyclophosphamide for ANCA-associated vasculitis",
"pmid" : "20647199"
},
{
"timestamp" : "2017-12-03T22:38:51Z",
"briefDesignDescription" : "Dabigatran in mechanical heart valves",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300615",
"pageid" : 1707,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300615",
"trainingLevel" : "Resident",
"citation" : "Eikelboom JW, et al. \"Dabigatran versus warfarin in patients with mechanical heart valves\". The New England Journal of Medicine. 2013. 369(13):1206-1214.",
"subspecialties" : "Cardiology;Hematology",
"expansion" : "Randomized, Phase II Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients after Heart Valve Replacement",
"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Dabigatran has more thromboembolism and bleeding than warfarin",
"published" : "2013-09-26",
"pageName" : "RE-ALIGN",
"diseases" : "Valvular Disease",
"abbreviation" : "RE-ALIGN",
"title" : "Dabigatran versus warfarin in patients with mechanical heart valves",
"pmid" : "23991661"
},
{
"timestamp" : "2017-12-03T22:38:52Z",
"briefDesignDescription" : "Dabigatran vs. warfarin in VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906598",
"pageid" : 973,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906598",
"trainingLevel" : "fellow",
"citation" : "Schulman S, et al. \"Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism\". New England Journal of Medicine. 2009. 361(24):2342-52.",
"subspecialties" : "Hematology;Pulmonology",
"expansion" : "Efficacy and Safety of Dabigatran Compared to Warfarin for 6 Month Treatment of Acute Symptomatic Venous Thromboembolism",
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Dabigatran non-inferior to warfarin for VTE recurrence, but dabigatran yielded less bleeding",
"published" : "2009-12-10",
"pageName" : "RE-COVER",
"diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "RE-COVER",
"title" : "Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism",
"pmid" : "19966341"
},
{
"timestamp" : "2018-01-30T17:09:14Z",
"briefDesignDescription" : "Triple therapy vs. ASA+dabigatran in PCI if AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1708454",
"pageid" : 3527,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1708454",
"trainingLevel" : "Resident",
"citation" : "Cannon CP, et al. \"Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation\". The New England Journal of Medicine. 2017. 377(16):1513-1524.",
"subspecialties" : "Cardiology",
"expansion" : "Randomized evaluation of dual antithrombotic therapy with dabigatran versus triple therapy with warfarin in patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention",
"statusUsableDate" : "2018-01-29",
"briefResultsDescription" : "Aspirin and dabigatran nonferior to triple therapy in patients with AF undergoing PCI",
"published" : "2017-10-19",
"pageName" : "RE-DUAL",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "RE-DUAL PCI",
"title" : "Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation",
"pmid" : "28844193"
},
{
"timestamp" : "2015-04-18T21:22:31Z",
"briefDesignDescription" : "Dabigatran vs. warfarin in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0905561",
"pageid" : 178,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0905561",
"trainingLevel" : "Resident",
"citation" : "Connolly SJ, et al. \"Dabigatran versus warfarin in patients with atrial fibrillation\". The New England Journal of Medicine. 2009. 361(12):1139-51.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Randomized Evaluation of Long-Term Anticoagulation Therapy",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "High-dose dabigatran reduces stroke risk without increasing major bleeding in atrial fibrillation",
"published" : "2009-09-17",
"pageName" : "RE-LY",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"abbreviation" : "RE-LY",
"title" : "Dabigatran versus warfarin in patients with atrial fibrillation",
"pmid" : "19717844"
},
{
"timestamp" : "2017-12-03T22:38:54Z",
"briefDesignDescription" : "Idarucizumab for dabigatran reversal",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1502000",
"pageid" : 2421,
"pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1502000",
"trainingLevel" : "Intern",
"citation" : "Pollack CV, et al. \"Idarucizumab for Dabigatran Reversal\". The New England Journal of Medicine. 2015. 373(6):511-520.",
"subspecialties" : "Hematology",
"expansion" : "",
"statusUsableDate" : "2016-01-01",
"briefResultsDescription" : "Idarucizumab reversed the dabigatran effect in minutes",
"published" : "2015-08-06",
"pageName" : "RE-VERSE AD",
"diseases" : "Hemorrhage",
"abbreviation" : "RE-VERSE AD",
"title" : "Idarucizumab for Dabigatran Reversal",
"pmid" : "26095746"
},
{
"timestamp" : "2021-08-05T18:21:13Z",
"briefDesignDescription" : "Transfusion thresholds in MI",
"fulltexturl" : "https://doi.org/10.1001/jama.2021.0135",
"pageid" : 4431,
"pdfurl" : null,
"trainingLevel" : "Resident",
"citation" : "Ducrocq G, et al. \"Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia\". Journal of the American Medical Association. 2021. 325(6):552-560.",
"subspecialties" : "Cardiology",
"expansion" : "Restrictive and Liberal Transfusion Strategies in Patients With Acute Myocardial Infarction trial",
"statusUsableDate" : "2021-07-31",
"briefResultsDescription" : "Restrictive threshold non-inferior to liberal transfusion threshold",
"published" : "2021-02-09",
"pageName" : "REALITY",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "REALITY",
"title" : "Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia",
"pmid" : "33560322"
},
{
"timestamp" : "2020-10-29T17:10:25Z",
"briefDesignDescription" : "Dexamethasone vs. usual care in Covid-19",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2021436",
"pageid" : 4273,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021436",
"trainingLevel" : "Student",
"citation" : "Horby P, et al. \"Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report\". The New England Journal of Medicine. 2020. e-pub 2020-07-17:1-11.",
"subspecialties" : "Infectious Disease",
"expansion" : "Randomized Evaluation of Covid-19 Therapy",
"statusUsableDate" : "2020-08-20",
"briefResultsDescription" : "Dexamethasone improved survival in a subset of patients with Covid-19",
"published" : "2020-07-17",
"pageName" : "RECOVERY (Covid-19)",
"diseases" : "Covid-19",
"abbreviation" : "RECOVERY",
"title" : "Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report",
"pmid" : "32678530"
},
{
"timestamp" : "2017-12-03T22:38:55Z",
"briefDesignDescription" : "Darbepoetin in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1214865",
"pageid" : 1842,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214865",
"trainingLevel" : "Fellow",
"citation" : "Swedberg K, et al. \"Treatment of anemia with darbepoetin alfa in systolic heart failure\". The New England Journal of Medicine. 2013. 368(13):1210-9.",
"subspecialties" : "Cardiology;Hematology",
"expansion" : "Reduction of Events by Darbepoetin Alfa in Heart Failure",
"statusUsableDate" : "2014-06-01",
"briefResultsDescription" : "Darbepoetin does not improve clinical outcomes in HF with anemia",
"published" : "2013-03-28",
"pageName" : "RED-HF",
"diseases" : "Heart Failure;Anemia",
"abbreviation" : "RED-HF",
"title" : "Treatment of anemia with darbepoetin alfa in systolic heart failure",
"pmid" : "23473338"
},
{
"timestamp" : "2017-12-03T22:38:56Z",
"briefDesignDescription" : "5d vs. 14d steroids in acute COPD",
"fulltexturl" : "http://bit.ly/1BQhpuy",
"pageid" : 1615,
"pdfurl" : null,
"trainingLevel" : "Intern",
"citation" : "Leuppi JD, et al. \"Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial\". JAMA. 2013. 309(21):2223-2231.",
"subspecialties" : "Pulmonology",
"expansion" : "Reduction in the Use of Corticosteroids in Exacerbated COPD",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "5d steroids noninferior to 14d in acute COPD",
"published" : "2013-06-05",
"pageName" : "REDUCE",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"abbreviation" : "REDUCE",
"title" : "Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial",
"pmid" : "23695200"
},
{
"timestamp" : "2019-10-17T17:47:07Z",
"briefDesignDescription" : "Icosapent ethyl in CAD",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812792",
"pageid" : 3748,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812792",
"trainingLevel" : "Resident",
"citation" : "Bhatt DL, et al. \"Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia\". The New England Journal of Medicine. 2018. epub 2018-11-10:1-12.",
"subspecialties" : "Cardiology",
"expansion" : "Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial",
"statusUsableDate" : "2018-12-27",
"briefResultsDescription" : "Icosapent ethyl superior to placebo in CAD with hypertriglyceridemia",
"published" : "2018-11-10",
"pageName" : "REDUCE-IT",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "REDUCE-IT",
"title" : "Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia",
"pmid" : "30415628"
},
{
"timestamp" : "2017-12-03T22:38:58Z",
"briefDesignDescription" : "Sildenafil vs. placebo in HFpEF",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/1663257",
"pageid" : 2973,
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/1663257/joc130025_1268_1277.pdf",
"trainingLevel" : "Resident",
"citation" : "Redfield MM, et al. \"Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction\". JAMA. 2013. 309(12):1268-1277.",
"subspecialties" : "Cardiology",
"expansion" : "Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction",
"statusUsableDate" : "2017-10-01",
"briefResultsDescription" : "Sildenafil not superior to placebo in HFpEF",
"published" : "2013-03-11",
"pageName" : "RELAX",
"diseases" : "Heart Failure",
"abbreviation" : "RELAX",
"title" : "Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction",
"pmid" : "23478662"
},
{
"timestamp" : "2019-04-11T17:01:50Z",
"briefDesignDescription" : "Destination LVAD in end-stage heart failure",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa012175",
"pageid" : 2822,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa012175",
"trainingLevel" : "Fellow",
"citation" : "Rose EA, et al. \"Long-term use of a left ventricular assist device for end-stage heart failure\". The New England Journal of Medicine. 2001. 345(20):1435-43.",
"subspecialties" : "Cardiology",
"expansion" : "Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure",
"statusUsableDate" : "2019-04-11",
"briefResultsDescription" : "LVAD reduced all-cause mortality in end-stage heart failure",
"published" : "2001-11-15",
"pageName" : "REMATCH",
"diseases" : "Heart Failure",
"abbreviation" : "REMATCH",
"title" : "Long-term use of a left ventricular assist device for end-stage heart failure",
"pmid" : "11794191"
},
{
"timestamp" : "2017-12-03T22:38:59Z",
"briefDesignDescription" : "ARBs in diabetic nephropathy",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011161",
"pageid" : 1030,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011161",
"trainingLevel" : "Intern",
"citation" : "Brenner BM, et al. \"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy\". The New England Journal of Medicine. 2001. 345(12):861-869.",
"subspecialties" : "Endocrinology;Nephrology",
"expansion" : "Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan",
"statusUsableDate" : "2013-01-01",
"briefResultsDescription" : "ARBs reduce progression to",
"published" : "2001-09-20",
"pageName" : "RENAAL",
"diseases" : "Diabetes Mellitus;Chronic Kidney Disease",
"abbreviation" : "RENAAL",
"title" : "Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy",
"pmid" : "11565518"
},
{
"timestamp" : "2018-07-22T21:45:32Z",
"briefDesignDescription" : "Craniectomy vs. medical care for intracranial hypertension",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1605215",
"pageid" : 3596,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1605215",
"trainingLevel" : "Resident",
"citation" : "Hutchinson PJ, et al. \"Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension\". The New England Journal of Medicine. 2016. 375(12):1119-30.",
"subspecialties" : "Surgery;Neurology",
"expansion" : "Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure",
"statusUsableDate" : "2018-07-19",
"briefResultsDescription" : "Craniectomy reduced mortality by 22% compared to usual care",
"published" : "2016-09-22",
"pageName" : "RESCUEicp",
"diseases" : "Intracranial Hypertension;Traumatic Brain Injury",
"abbreviation" : "RESCUEicp",
"title" : "Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension",
"pmid" : "27602507"
},
{
"timestamp" : "2017-12-03T22:39:00Z",
"briefDesignDescription" : "PFO closure in cryptogenic stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1301440",
"pageid" : 1334,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1301440",
"trainingLevel" : "Intern",
"citation" : "Carroll JD, et al. \"Closure of patent foramen ovale versus medical therapy after cryptogenic stroke\". The New England Journal of Medicine. 2013. 368(12):1092-1100.",
"subspecialties" : "Neurology;Cardiology",
"expansion" : "Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "PFO closure does not reduce recurrent CVA after cryptogenic CVA",
"published" : "2013-03-21",
"pageName" : "RESPECT",
"diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
"abbreviation" : "RESPECT",
"title" : "Closure of patent foramen ovale versus medical therapy after cryptogenic stroke",
"pmid" : "23514286"
},
{
"timestamp" : "2017-12-03T22:39:03Z",
"briefDesignDescription" : "Rifaximin/lactulose vs. lactulose for acute HE",
"fulltexturl" : "http://www.nature.com/ajg/journal/v108/n9/full/ajg2013219a.html",
"pageid" : 1784,
"pdfurl" : "http://www.nature.com/ajg/journal/v108/n9/pdf/ajg2013219a.pdf",
"trainingLevel" : "Intern",
"citation" : "Sharma BC, et al. \"A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy\". The American Journal of Gastroenterology. 2013. 108(9):1458-1463.",
"subspecialties" : "Gastroenterology",
"expansion" : "",
"statusUsableDate" : "2014-03-01",
"briefResultsDescription" : "Rifaximin/lactulose improved rates of HE reversal and survival, reduced hospital LOS",
"published" : "2013-09-01",
"pageName" : "Rifaximin and Lactulose for HE",
"diseases" : "Hepatic Encephalopathy",
"abbreviation" : "",
"title" : "A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy",
"pmid" : "23877348"
},
{
"timestamp" : "2022-03-10T21:09:46Z",
"briefDesignDescription" : "Rituximab in ANCA-Renal Vasculitis",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa0909169",
"pageid" : 4459,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa0909169",
"trainingLevel" : "fellow",
"citation" : "Jones RB, et al. \"Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis\". The New England Journal of Medicine. 2010. 363(3):211-232.",
"subspecialties" : "Rheumatology;Nephrology",
"expansion" : "",
"statusUsableDate" : "2022-03-10",
"briefResultsDescription" : "Rituximab not superior to cyclophosphamide",
"published" : "2010-07-15",
"pageName" : "RITUXVAS",
"diseases" : "Vasculitis;ANCA-Associated Vasculitis;Renal Vasculitis",
"abbreviation" : "RITUXVAS",
"title" : "Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis",
"pmid" : "20647198"
},
{
"timestamp" : "2022-04-19T13:00:26Z",
"briefDesignDescription" : "Early goal-directed therapy in sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010307",
"pageid" : 60,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010307",
"trainingLevel" : "Student",
"citation" : "Rivers E, et al. \"Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock\". The New England Journal of Medicine. 2001. 345(19):1368-1377.",
"subspecialties" : "Critical Care;Emergency Medicine",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Early goal-directed therapy decreased mortality and morbiditiy in sepsis",
"published" : "2001-11-08",
"pageName" : "Rivers Trial",
"diseases" : "Sepsis;Shock",
"abbreviation" : "",
"title" : "Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock",
"pmid" : "11794169"
},
{
"timestamp" : "2017-12-03T22:39:02Z",
"briefDesignDescription" : "Rivaroxaban vs. warfarin in AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009638",
"pageid" : 1358,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009638",
"trainingLevel" : "Student",
"citation" : "Patel MR, et al. \"Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation\". The New England Journal of Medicine. 2011. 365(10):883-891.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "Rivaroxaban is noninferior to warfarin for stroke/embolization prevention in nonvalvular AF",
"published" : "2011-09-08",
"pageName" : "ROCKET AF",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"abbreviation" : "ROCKET AF",
"title" : "Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation",
"pmid" : "21830957"
},
{
"timestamp" : "2020-07-12T00:30:51Z",
"briefDesignDescription" : "Cisatracurium NM blockade in ARDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1901686",
"pageid" : 4070,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1901686",
"trainingLevel" : "Resident",
"citation" : "National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. \"Early neuromuscular blockade in the acute respiratory distress syndrome\". The New England Journal of Medicine. 2019. 380(21):1997-2008.",
"subspecialties" : "Critical Care",
"expansion" : "Reevaluation of Systemic Early Neuromuscular Blockade",
"statusUsableDate" : "2019-06-14",
"briefResultsDescription" : "Cisatracurium blockade doesn't improve outcomes in ARDS",
"published" : "2019-05-23",
"pageName" : "ROSE",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "ROSE",
"title" : "Early neuromuscular blockade in the acute respiratory distress syndrome",
"pmid" : "31112383"
},
{
"timestamp" : "2022-12-01T20:14:11Z",
"briefDesignDescription" : "Water intake to prevent UTI",
"fulltexturl" : "https://doi.org/10.1001/jamainternmed.2018.4204",
"pageid" : 4072,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "Hooton TM, et al. \"Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections\". JAMA Internal Medicine. 2018. 178(11):1509-1515.",
"subspecialties" : "Infectious Disease;Urology;Gynecology",
"expansion" : "",
"statusUsableDate" : "2019-09-15",
"briefResultsDescription" : "Drinking more water reduces recurrent UTIs in premenopausal women",
"published" : "2018-10-01",
"pageName" : "S-HYDRACYST",
"diseases" : "Urinary Tract Infections",
"abbreviation" : "",
"title" : "Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections",
"pmid" : "30285042"
},
{
"timestamp" : "2018-09-04T17:00:07Z",
"briefDesignDescription" : "Sertraline for depression post-ACS",
"fulltexturl" : "http://jama.ama-assn.org/content/288/6/701.full",
"pageid" : 423,
"pdfurl" : "http://jama.ama-assn.org/content/288/6/701.full.pdf",
"trainingLevel" : "Resident",
"citation" : "Glassman AH, et al. \"Sertraline treatment of major depression in patients with acute MI or unstable angina\". Journal of the American Medical Association. 2002. 288(6):701-709.",
"subspecialties" : "Psychiatry;Cardiology",
"expansion" : "Sertraline Antidepressant Heart Attack Randomized Trial",
"statusUsableDate" : "2012-05-01",
"briefResultsDescription" : "Sertraline improves symptoms without adverse CV effects",
"published" : "2002-08-14",
"pageName" : "SADHART",
"diseases" : "Depression;Acute Coronary Syndrome",
"abbreviation" : "SADHAT",
"title" : "Sertraline treatment of major depression in patients with acute MI or unstable angina",
"pmid" : "12169073"
},
{
"timestamp" : "2017-01-19T20:07:27Z",
"briefDesignDescription" : "Albumin vs. saline in ICU",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040232",
"pageid" : 285,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040232",
"trainingLevel" : "Intern",
"citation" : "Finfer S, et al. \"A comparison of albumin and saline for fluid resuscitation in the intensive care unit\". The New England Journal of Medicine. 2004. 350(22):2247-2256.",
"subspecialties" : "Critical Care",
"expansion" : "Saline versus Albumin Fluid Evaluation",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No mortality difference (except worse mortality with albumin for TBI)",
"published" : "2004-05-27",
"pageName" : "SAFE",
"diseases" : "Critical Illness",
"abbreviation" : "SAFE",
"title" : "A comparison of albumin and saline for fluid resuscitation in the intensive care unit",
"pmid" : "15163774"
},
{
"timestamp" : "2018-04-05T18:17:47Z",
"briefDesignDescription" : "Balanced crystalloids vs. NS in non-critical ED patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711586",
"pageid" : 3556,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711586",
"trainingLevel" : "Student",
"citation" : "Self WH, et al. \"Balanced crystalloids versus saline in noncritically ill adults\". The New England Journal of Medicine. 2018. 378(10):819-828.",
"subspecialties" : "Critical Care;Nephrology",
"expansion" : "Saline Against Lactated Ringer's or Plasma-Lyte in the Emergency Department",
"statusUsableDate" : "2018-04-05",
"briefResultsDescription" : "Balanced crystalloids result in fewer renal abnormalities",
"published" : "2018-03-01",
"pageName" : "SALT-ED",
"diseases" : "Hypovolemia;Acute Kidney Injury",
"abbreviation" : "SALT-ED",
"title" : "Balanced crystalloids versus saline in noncritically ill adults",
"pmid" : "29485926"
},
{
"timestamp" : "2019-06-27T16:40:34Z",
"briefDesignDescription" : "Stenting in intracranial stenosis",
"fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa1105335",
"pageid" : 2420,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa1105335",
"trainingLevel" : "Intern",
"citation" : "Chimowitz MI, et al. \"Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis\". The New England Journal of Medicine. 2015. 365(11):993-1003.",
"subspecialties" : "Neurology;Interventional Radiology",
"expansion" : "",
"statusUsableDate" : "2016-03-01",
"briefResultsDescription" : "Medical therapy superior to stenting in IC stenosis",
"published" : "2011-09-15",
"pageName" : "SAMMPRIS",
"diseases" : "Stroke",
"abbreviation" : "SAMMPRIS",
"title" : "Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis",
"pmid" : "24168957"
},
{
"timestamp" : "2015-08-24T04:52:18Z",
"briefDesignDescription" : "Captopril in MI with LV dysfunction",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199209033271001",
"pageid" : 150,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199209033271001",
"trainingLevel" : "Resident",
"citation" : "Pfeffer MA, et al. \"Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial\". The New England Journal of Medicine. 1992. 327(10):669-677.",
"subspecialties" : "Cardiology",
"expansion" : "Survival and Ventricular Enlargement Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Captopril improves survival",
"published" : "1992-09-03",
"pageName" : "SAVE",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Heart Failure",
"abbreviation" : "SAVE",
"title" : "Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial",
"pmid" : "1386652"
},
{
"timestamp" : "2019-05-16T20:18:55Z",
"briefDesignDescription" : "Amiodarone or ICD in severe HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa043399",
"pageid" : 40,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043399",
"trainingLevel" : "Intern",
"citation" : "Bardy GH, et al. \"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure\". The New England Journal of Medicine. 2005. 252(3):225-37.",
"subspecialties" : "Cardiology",
"expansion" : "Sudden Cardiac Death in Heart Failure Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "ICD reduces mortality by 23% in class II-III HFrEF",
"published" : "2005-01-20",
"pageName" : "SCD-HeFT",
"diseases" : "Heart Failure",
"abbreviation" : "SCD-HeFT",
"title" : "Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure",
"pmid" : "15659722"
},
{
"timestamp" : "2021-02-14T17:21:07Z",
"briefDesignDescription" : "Dexmedetomidine vs. midazolam for sedation",
"fulltexturl" : "http://jama.ama-assn.org/content/301/5/489.long",
"pageid" : 353,
"pdfurl" : "http://jama.ama-assn.org/content/301/5/489.full.pdf",
"trainingLevel" : "Resident",
"citation" : "Riker RR, et al. \"Dexmedetomidine vs. Midazolam for Sedation of Critically Ill Patients\". Journal of American Medical Association. 2009. 301(5):489-499.",
"subspecialties" : "Critical Care",
"expansion" : "Safety and Efficacy of Dexmedetomidine Compared with Midazolam",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "↓ delirium, ↓ ventilator days with dexmedetomidine",
"published" : "2009-02-04",
"pageName" : "SEDCOM",
"diseases" : "Critical Illness",
"abbreviation" : "SEDCOM",
"title" : "Dexmedetomidine vs. Midazolam for Sedation of Critically Ill Patients",
"pmid" : "19188334"
},
{
"timestamp" : "2023-11-22T19:59:22Z",
"briefDesignDescription" : "GLP-1 if prior CVD, BMI ≥27, no DM",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2307563",
"pageid" : 5457,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2307563",
"trainingLevel" : "student",
"citation" : "Lincoff AM, et al. \"Semaglutide and cardiovascular outcomes in obesity without diabetes\". The New England Journal of Medicine. 2023. Epub 2023-11-11:1-12.",
"subspecialties" : "Cardiology",
"expansion" : "Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity",
"statusUsableDate" : "2023-11-15",
"briefResultsDescription" : "GLP-1 lowers CVD risk in non-diabetics with high BMI and prior CVD",
"published" : "2023-11-11",
"pageName" : "SELECT",
"diseases" : "Cardiovascular disease",
"abbreviation" : "SELECT",
"title" : "Semaglutide and cardiovascular outcomes in obesity without diabetes",
"pmid" : "37952131"
},
{
"timestamp" : "2020-10-29T17:37:48Z",
"briefDesignDescription" : "Rivaroxaban vs. LMWH in cancer VTE",
"fulltexturl" : "http://ascopubs.org/doi/full/10.1200/JCO.2018.78.8034",
"pageid" : 3717,
"pdfurl" : "http://ascopubs.org/doi/pdfdirect/10.1200/JCO.2018.78.8034",
"trainingLevel" : "Resident",
"citation" : "Young AM, et al. \"Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D)\". Journal of Clinical Oncology. 2018. 36(20):2017-23.",
"subspecialties" : "Hematology;Oncology",
"expansion" : "Anticoagulation Therapy in Selected Cancer Patients at Risk of Recurrence of Venous Thromboembolism",
"statusUsableDate" : "2018-12-20",
"briefResultsDescription" : "Rivaroxaban noninferior to dalteparin in cancer VTE",
"published" : "2018-07-10",
"pageName" : "SELECT-D",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"abbreviation" : "SELECT-D",
"title" : "Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D)",
"pmid" : "29746227"
},
{
"timestamp" : "2019-04-24T01:13:29Z",
"briefDesignDescription" : "MAP 65-70 vs. 80-85 mmHg in sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1312173",
"pageid" : 1779,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1312173",
"trainingLevel" : "Resident",
"citation" : "Asfar P, et al. \"High versus low blood-pressure target in patients with septic shock\". The New England Journal of Medicine. 2014. 370(17):1583-1593.",
"subspecialties" : "Critical Care",
"expansion" : "Sepsis and Mean Arterial Pressure",
"statusUsableDate" : "2014-04-01",
"briefResultsDescription" : "No difference for higher MAP in sepsis except renal protection in vascular disease",
"published" : "2014-04-23",
"pageName" : "SEPSISPAM",
"diseases" : "Sepsis;Shock",
"abbreviation" : "SEPSISPAM",
"title" : "High versus low blood-pressure target in patients with septic shock",
"pmid" : "24635770"
},
{
"timestamp" : "2017-12-03T22:39:10Z",
"briefDesignDescription" : "Ivabradine in HFrEF",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0140673610611981",
"pageid" : 2735,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(10)61198-1.pdf",
"trainingLevel" : "Resident",
"citation" : "Swedberg K et al. \"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study\". Lancet. 2010. 376(10):875-885.",
"subspecialties" : "Cardiology",
"expansion" : "Systolic Heart failure treatment with the If inhibitor ivabradine Trial",
"statusUsableDate" : "2016-05-01",
"briefResultsDescription" : "Ivabradine improves mortality and heart failure hospitalization in HFrEF",
"published" : "2010-09-11",
"pageName" : "SHIFT",
"diseases" : "Heart Failure",
"abbreviation" : "SHIFT",
"title" : "Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study",
"pmid" : "20801500"
},
{
"timestamp" : "2017-12-03T22:39:12Z",
"briefDesignDescription" : "Early PCI/CABG in MI + shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199908263410901",
"pageid" : 388,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199908263410901",
"trainingLevel" : "Resident",
"citation" : "Hochman JS, et al. \"Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock\". The New England Journal of Medicine. 1999. 341(9):625-634.",
"subspecialties" : "Cardiology;Critical Care",
"expansion" : "SHould we emergently revascularize Occluded Coronaries for Cardiogenic shocK",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "Early PCI/CABG improves survival in acute MI and cardiogenic shock",
"published" : "1999-08-26",
"pageName" : "SHOCK",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
"abbreviation" : "SHOCK",
"title" : "Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock",
"pmid" : "10460813"
},
{
"timestamp" : "2017-12-03T22:39:13Z",
"briefDesignDescription" : "Salmeterol in asthma",
"fulltexturl" : "http://bit.ly/1VSBfoL",
"pageid" : 512,
"pdfurl" : "http://journal.publications.chestnet.org/data/Journals/CHEST/22038/15.pdf",
"trainingLevel" : "intern",
"citation" : "Nelson HS, et al. \"The salmeterol multicenter asthma research trial\". Chest. 2006. 129(1):15-26.",
"subspecialties" : "Pulmonology",
"expansion" : "Salmeterol Multicenter Asthma Research Trial",
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Salmeterol increases death in subgroups",
"published" : "2006-01-01",
"pageName" : "SMART",
"diseases" : "Asthma",
"abbreviation" : "SMART",
"title" : "The salmeterol multicenter asthma research trial",
"pmid" : "16424409"
},
{
"timestamp" : "2018-04-05T17:39:53Z",
"briefDesignDescription" : "NS vs. balanced crystalloids in ICU",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711584",
"pageid" : 3555,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711584",
"trainingLevel" : "student",
"citation" : "Semler MW, et al. \"Balanced Crystalloids versus Saline in Critically Ill Adults\". The New England Journal of Medicine. 2018. 378(9):829-839.",
"subspecialties" : "Critical Care;Nephrology",
"expansion" : "Isotonic Solutions and Major Adverse Renal Events Trial",
"statusUsableDate" : "2018-04-05",
"briefResultsDescription" : "Balanced crystalloids slightly reduced composite rate of death, RRT, or CKD",
"published" : "2018-03-01",
"pageName" : "SMART-MED and SMART-SURG",
"diseases" : "Critical Illness",
"abbreviation" : "SMART",
"title" : "Balanced Crystalloids versus Saline in Critically Ill Adults",
"pmid" : "29485925"
},
{
"timestamp" : "2017-01-19T19:50:29Z",
"briefDesignDescription" : "Dopamine vs. norepinephrine in shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907118",
"pageid" : 113,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907118",
"trainingLevel" : "Intern",
"citation" : "De Backer D, et al. \"Comparison of dopamine and norepinephrine in the treatment of shock\". The New England Journal of Medicine. 2010. 362(9):779-89.",
"subspecialties" : "Critical Care;Emergency Medicine",
"expansion" : "Sepsis Occurrence in Acutely Ill Patients II",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Norepinephrine reduces mortality",
"published" : "2010-03-04",
"pageName" : "SOAP II",
"diseases" : "Sepsis;Shock",
"abbreviation" : "SOAP II",
"title" : "Comparison of dopamine and norepinephrine in the treatment of shock",
"pmid" : "20200382"
},
{
"timestamp" : "2017-12-03T22:39:15Z",
"briefDesignDescription" : "Ticagrelor vs. aspirin in acute stroke or TIA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603060",
"pageid" : 2809,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603060",
"trainingLevel" : "Resident",
"citation" : "Johnston SC, et al. \"Ticagrelor versus aspirin in acute stroke or transient ischemic attack\". New Engl J Med. 2016. 365(1):35-43.",
"subspecialties" : "Neurology",
"expansion" : "Ticagrelor versus aspirin in stroke/TIA",
"statusUsableDate" : "2016-10-01",
"briefResultsDescription" : "Ticagrelor not superior to aspirin in acute stroke or TIA",
"published" : "2016-07-07",
"pageName" : "SOCRATES",
"diseases" : "Stroke",
"abbreviation" : "SOCRATES",
"title" : "Ticagrelor versus aspirin in acute stroke or transient ischemic attack",
"pmid" : "27160892"
},
{
"timestamp" : "2017-12-03T22:39:16Z",
"briefDesignDescription" : "Enalapril in moderate-severe HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199108013250501",
"pageid" : 394,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199108013250501",
"trainingLevel" : "Resident",
"citation" : "Yusuf S, et al. \"Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure\". The New England Journal of Medicine. 1991. 325(5):293-302.",
"subspecialties" : "Cardiology",
"expansion" : "Studies of Left Ventricular Dysfunction",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "Enalapril reduces mortality and HF hospitalizations in HFrEF",
"published" : "1991-08-01",
"pageName" : "SOLVD",
"diseases" : "Heart Failure",
"abbreviation" : "SOLVD",
"title" : "Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure",
"pmid" : "2057034"
},
{
"timestamp" : "2018-08-30T18:21:05Z",
"briefDesignDescription" : "Occult cancer screening in unprovoked VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506623",
"pageid" : 2498,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506623",
"trainingLevel" : "Intern",
"citation" : "Carrier M, et al. \"Screening for Occult Cancer in Unprovoked Venous Thromboembolism\". The New England Journal of Medicine. 2015. 373(8):697-704.",
"subspecialties" : "Oncology;Hematology",
"expansion" : "",
"statusUsableDate" : "2018-08-30",
"briefResultsDescription" : "No benefit over age-appropriate screening",
"published" : "2015-08-20",
"pageName" : "SOME",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"abbreviation" : "SOME",
"title" : "Screening for Occult Cancer in Unprovoked Venous Thromboembolism",
"pmid" : "26095467"
},
{
"timestamp" : "2017-12-03T22:39:17Z",
"briefDesignDescription" : "Infliximab ± azathioprine induction in Crohn disease",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0904492",
"pageid" : 1863,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0904492",
"trainingLevel" : "Intern",
"citation" : "Colombel JF, et al. \"Infliximab, azathioprine, or combination therapy for Crohn's disease\". The New England Journal of Medicine. 2010. 362(15):1383-1395.",
"subspecialties" : "Gastroenterology",
"expansion" : "Study of Biologic and Immunomodulator Naive Patients in Crohn's Disease",
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Combination therapy better than infliximab or azathioprine for Crohn disease induction therapy",
"published" : "2010-04-15",
"pageName" : "SONIC",
"diseases" : "Inflammatory Bowel Disease;Crohn Disease",
"abbreviation" : "SONIC",
"title" : "Infliximab, azathioprine, or combination therapy for Crohn's disease",
"pmid" : "20393175"
},
{
"timestamp" : "2019-06-28T16:43:02Z",
"briefDesignDescription" : "Opioids vs. non-opioids in chronic MSK pain",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2018.0899",
"pageid" : 3620,
"pdfurl" : "",
"trainingLevel" : "student",
"citation" : "Krebs EE, et al. \"Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain\". JAMA. 2018. 319(9):872-882.",
"subspecialties" : "Emergency Medicine;Pain Medicine",
"expansion" : "Strategies for Prescribing Analgesics Comparative Effectiveness",
"statusUsableDate" : "2019-06-27",
"briefResultsDescription" : "Opioids without benefit over non-opioid management for chronic MSK pain",
"published" : "2018-06-03",
"pageName" : "SPACE",
"diseases" : "Chronic Pain",
"abbreviation" : "SPACE",
"title" : "Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain",
"pmid" : "29509867"
},
{
"timestamp" : "2017-12-03T22:39:18Z",
"briefDesignDescription" : "Aspirin and warfarin in AF",
"fulltexturl" : "http://circ.ahajournals.org/content/84/2/527.long",
"pageid" : 2340,
"pdfurl" : "http://circ.ahajournals.org/content/84/2/527.full.pdf",
"trainingLevel" : "Resident",
"citation" : "SPAF Investigators. \"Stroke Prevention in Atrial Fibrillation Study. Final results\". Circulation. 1991. 84(2):527-39.",
"subspecialties" : "Cardiology;Neurology",
"expansion" : "Stroke Prevention in Atrial Fibrillation",
"statusUsableDate" : "2016-08-01",
"briefResultsDescription" : "Aspirin and warfarin reduce stroke incidence in AF",
"published" : "1991-08-01",
"pageName" : "SPAF",
"diseases" : "Atrial Fibrillation;Stroke",
"abbreviation" : "SPAF",
"title" : "Stroke Prevention in Atrial Fibrillation Study. Final results",
"pmid" : "1860198"
},
{
"timestamp" : "2017-12-03T22:39:20Z",
"briefDesignDescription" : "Atorvastatin after stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061894",
"pageid" : 461,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061894",
"trainingLevel" : "intern",
"citation" : "Amarenco P, et al. \"High-dose atorvastatin after stroke or transient ischemic attack\". The New England Journal of Medicine. 2006. 355(6):549-559.",
"subspecialties" : "Neurology",
"expansion" : "Stroke Prevention by Aggressive Reduction in Cholesterol Levels",
"statusUsableDate" : "2012-06-01",
"briefResultsDescription" : "Atorvastatin ↓stroke risk in general but slightly ↑hemorrhagic strokes",
"published" : "2006-08-10",
"pageName" : "SPARCL",
"diseases" : "Stroke;Hyperlipidemia;Transient Ischemic Attack",
"abbreviation" : "SPARCL",
"title" : "High-dose atorvastatin after stroke or transient ischemic attack",
"pmid" : "16899775"
},
{
"timestamp" : "2021-10-26T13:55:55Z",
"briefDesignDescription" : "Dexmedetomidine in ICU sedation",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1904710",
"pageid" : 4073,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1904710?articleTools",
"trainingLevel" : "Fellow",
"citation" : "Shehabi Y, et al. \"Early Sedation with Dexmedetomidine in Critically Ill Patients\". The New England Journal of Medicine. 2019. 380(26):2506-2517.",
"subspecialties" : "Critical Care",
"expansion" : "Sedation Practice in Intensive Care Evaluation",
"statusUsableDate" : "2020-05-14",
"briefResultsDescription" : "Dexmedetomidine with more adverse events vs. usual care",
"published" : "2019-05-19",
"pageName" : "SPICE III",
"diseases" : "Sedation;Delirium",
"abbreviation" : "SPICE III",
"title" : "Early Sedation with Dexmedetomidine in Critically Ill Patients",
"pmid" : "31112380"
},
{
"timestamp" : "2021-12-08T19:24:32Z",
"briefDesignDescription" : "BP targets in high-risk patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1511939",
"pageid" : 2487,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1511939",
"trainingLevel" : "Student",
"citation" : "The SPRINT Research Group. \"A randomized trial of intensive versus standard blood-pressure control\". The New England Journal of Medicine. 2015. 373(22):2103-2116.",
"subspecialties" : "Cardiology;Preventive Medicine",
"expansion" : "Systolic Blood Pressure Intervention Trial",
"statusUsableDate" : "2015-11-01",
"briefResultsDescription" : "SBP <120 improves CV outcomes with increased risks",
"published" : "2015-11-09",
"pageName" : "SPRINT",
"diseases" : "Hypertension",
"abbreviation" : "SPRINT",
"title" : "A randomized trial of intensive versus standard blood-pressure control",
"pmid" : "26551272"
},
{
"timestamp" : "2017-12-03T22:39:22Z",
"briefDesignDescription" : "Clopidogrel+ASA for lacunar strokes",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1204133",
"pageid" : 2678,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1204133",
"trainingLevel" : "Intern",
"citation" : "SPS3 Study Group writers. \"Effects of clopidogrel added to aspirin in patients with recent lacunar stroke\". New England Journal of Medicine. 2012. 367(9):817-825.",
"subspecialties" : "Neurology",
"expansion" : "Secondary Prevention of Small Subcortical Strokes clopidogrel+ASA",
"statusUsableDate" : "2016-06-01",
"briefResultsDescription" : "Clopidogrel+ASA increased all cause mortality compared to ASA alone",
"published" : "2012-08-30",
"pageName" : "SPS3 Clopidogrel-ASA",
"diseases" : "Stroke;Transient Ischemic Attack",
"abbreviation" : "SPS3-Clopidogrel+ASA",
"title" : "Effects of clopidogrel added to aspirin in patients with recent lacunar stroke",
"pmid" : "22931315"
},
{
"timestamp" : "2017-12-03T22:39:24Z",
"briefDesignDescription" : "SBP <130 vs. SBP 130-150 after lacunar strokes",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60852-1/abstract",
"pageid" : 2671,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(13)60852-1.pdf",
"trainingLevel" : "Intern",
"citation" : "SPS3 Study Group. \"Blood-pressure targets in patients with recent lacunar stroke\". The Lancet. 2013. 382(9891):507-515.",
"subspecialties" : "Neurology",
"expansion" : "Secondary Prevention of Small Subcortical Strokes-Blood Pressure",
"statusUsableDate" : "2016-01-01",
"briefResultsDescription" : "No significant difference in all stroke types between two groups",
"published" : "2013-05-29",
"pageName" : "SPS3-BP",
"diseases" : "Stroke",
"abbreviation" : "SPS3-BP",
"title" : "Blood-pressure targets in patients with recent lacunar stroke",
"pmid" : "23726159"
},
{
"timestamp" : "2018-06-29T18:11:38Z",
"briefDesignDescription" : "Renal denervation in resistant hypertension",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30951-6/fulltext",
"pageid" : 3642,
"pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(18)30951-6.pdf",
"trainingLevel" : "Resident",
"citation" : "Kandazi DE, et al. \"Effect of renal denervation on blood pressure in the presence of antihypertensive drugs\". The Lancet. 2018. 391:2346-55.",
"subspecialties" : "Cardiology",
"expansion" : "Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy",
"statusUsableDate" : "2018-06-12",
"briefResultsDescription" : "Renal denervation+meds is superior to medical therapy alone in resistant hypertension",
"published" : "2018-06-09",
"pageName" : "SPYRAL HTN-ON MED",
"diseases" : "Hypertension",
"abbreviation" : "SPYRAL HTN-ON MED",
"title" : "Effect of renal denervation on blood pressure in the presence of antihypertensive drugs",
"pmid" : "29803589"
},
{
"timestamp" : "2017-12-03T22:39:25Z",
"briefDesignDescription" : "Gastric bypass vs. medical therapy for T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200225",
"pageid" : 2266,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200225",
"trainingLevel" : "Resident",
"citation" : "Schauer PR, et al. \"Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes\". The New England Journal of Medicine. 2012. 366(17):1567-76.",
"subspecialties" : "Endocrinology;Surgery",
"expansion" : "Surgical Treatment and Medications Potentially Eradicate Diabetes Efficiently",
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Bypass plus medical therapy is superior to medical therapy alone",
"published" : "2012-04-26",
"pageName" : "STAMPEDE",
"diseases" : "Diabetes Mellitus;Obesity",
"abbreviation" : "STAMPEDE",
"title" : "Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes",
"pmid" : "22449319"
},
{
"timestamp" : "2017-12-03T22:39:26Z",
"briefDesignDescription" : "Tamoxifen vs. raloxifene in breast cancer prevention",
"fulltexturl" : "http://jama.jamanetwork.com/article.aspx?articleid",
"pageid" : 963,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5028/JOC60074.pdf",
"trainingLevel" : "Fellow",
"citation" : "Vogel VG, et al. \"Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes\". Journal of the American Medical Association. 2006. 295(23):2727-2741.",
"subspecialties" : "Oncology",
"expansion" : "Study of Tamoxifen and Raloxifene (NSABP P-2)",
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Similar reduction in breast cancer risk but fewer adverse effects with raloxifene",
"published" : "2006-06-21",
"pageName" : "STAR",
"diseases" : "Breast Cancer",
"abbreviation" : "STAR",
"title" : "Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes",
"pmid" : "16754727"
},
{
"timestamp" : "2017-12-03T22:39:27Z",
"briefDesignDescription" : "Tiered approach for depression",
"fulltexturl" : "",
"pageid" : 1564,
"pdfurl" : "http://ajp.psychiatryonline.org/data/Journals/AJP/3782/06aj1905.PDF",
"trainingLevel" : "Resident",
"citation" : "Rush AJ et al. \"Acute and longer-term outcomes in depressed outpatient requiring one or several treatment steps: A STAR*D report\". The American Journal of Psychiatry. 2006. 163(11):1905-1917.",
"subspecialties" : "Psychiatry",
"expansion" : "Sequenced Treatment Alternatives to Relieve Depression",
"statusUsableDate" : "2013-09-01",
"briefResultsDescription" : "Most patients achieved remission in first two steps",
"published" : "2006-11-01",
"pageName" : "STAR-D",
"diseases" : "Depression",
"abbreviation" : "STAR-D",
"title" : "Acute and longer-term outcomes in depressed outpatient requiring one or several treatment steps: A STAR*D report",
"pmid" : "17074942"
},
{
"timestamp" : "2023-02-04T04:10:40Z",
"briefDesignDescription" : "Intensive BP control hypertension",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2111437",
"pageid" : 4446,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2111437",
"trainingLevel" : "student",
"citation" : "Zhang W, et al. \"Trial of intensive blood-pressure control in older patients with hypertension\". The New England Journal of Medicine. 2021. 385(14):1268-1279.",
"subspecialties" : "Cardiology",
"expansion" : "Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients",
"statusUsableDate" : "2021-11-30",
"briefResultsDescription" : "Intensive BP control lowers CVD events",
"published" : "2021-09-30",
"pageName" : "STEP",
"diseases" : "Hypertension",
"abbreviation" : "STEP",
"title" : "Trial of intensive blood-pressure control in older patients with hypertension",
"pmid" : "34491661"
},
{
"timestamp" : "2023-11-11T23:27:35Z",
"briefDesignDescription" : "Semaglutide in obesity without diabetes",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2032183",
"pageid" : 4407,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2032183",
"trainingLevel" : "Resident",
"citation" : "Wilding JPH, et al. \"Once-Weekly Semaglutide in Adults with Overweight or Obesity\". The New England Journal of Medicine. 2021. 384(11):989-1002.",
"subspecialties" : "Endocrinology",
"expansion" : "Semaglutide Treatment Effect in People with Obesity 1",
"statusUsableDate" : "2021-04-22",
"briefResultsDescription" : "Semaglutide led to significant weight loss vs. placebo",
"published" : "2021-03-18",
"pageName" : "STEP 1",
"diseases" : "Obesity;Overweight",
"abbreviation" : "STEP 1",
"title" : "Once-Weekly Semaglutide in Adults with Overweight or Obesity",
"pmid" : "33567185"
},
{
"timestamp" : "2017-12-03T22:39:28Z",
"briefDesignDescription" : "CABG in ischemic HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1100356",
"pageid" : 471,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1100356",
"trainingLevel" : "Resident",
"citation" : "Velazquez EJ, et al. \"Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction\". The New England Journal of Medicine. 2011. 354(17):1607-1616.",
"subspecialties" : "Cardiology",
"expansion" : "Surgical Treatment for Ischemic Heart Failure",
"statusUsableDate" : "2012-12-01",
"briefResultsDescription" : "No mortality benefit with CABG vs. OMT though improved CV outcomes",
"published" : "2011-04-28",
"pageName" : "STICH",
"diseases" : "Heart Failure;Coronary Artery Disease",
"abbreviation" : "STICH",
"title" : "Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction",
"pmid" : "21463150"
},
{
"timestamp" : "2017-12-03T22:39:35Z",
"briefDesignDescription" : "BR vs. R-CHOP for indolent lymphomas",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(12)61763-2",
"pageid" : 1664,
"pdfurl" : "http://bit.ly/1owpykX",
"trainingLevel" : "fellow",
"citation" : "Rummel MJ, et al. \"Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial\". The Lancet. 2013. 381(9873):1203-10.",
"subspecialties" : "Oncology;Hematology",
"expansion" : "Study Group Indolent Lymphomas",
"statusUsableDate" : "2014-06-01",
"briefResultsDescription" : "BR superior to R-CHOP in PFS, similar in OS, less toxic",
"published" : "2013-04-03",
"pageName" : "StiL",
"diseases" : "Lymphoma",
"abbreviation" : "StiL",
"title" : "Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial",
"pmid" : "23433739"
},
{
"timestamp" : "2020-01-25T15:49:52Z",
"briefDesignDescription" : "Duration of abx in intraabdominal infection",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1411162",
"pageid" : 2424,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1411162",
"trainingLevel" : "Intern",
"citation" : "Sawyer RG, et al. \"Trial of short-course antimicrobial therapy for intraabdominal infection\". The New England Journal of Medicine. 2015. 372(21):1996-2005.",
"subspecialties" : "Infectious Disease",
"expansion" : "Study to Optimize Peritoneal Infection Therapy",
"statusUsableDate" : "2020-01-25",
"briefResultsDescription" : "Short duration non-inferior to longer duration in intraabdominal infection",
"published" : "2015-05-21",
"pageName" : "STOP-IT",
"diseases" : "Intraabdominal Infection",
"abbreviation" : "STOP-IT",
"title" : "Trial of short-course antimicrobial therapy for intraabdominal infection",
"pmid" : "25992746"
},
{
"timestamp" : "2023-08-03T18:09:18Z",
"briefDesignDescription" : "Acarbose to prevent diabetes in high-risk patients",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08905-5/fulltext",
"pageid" : 2754,
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(02)08905-5.pdf",
"trainingLevel" : "Resident",
"citation" : "Chiasson JL, et al. \"Acarbose for prevention of type 2 diabetes mellitus\". The Lancet. 2005. 359(9323):2072-2077.",
"subspecialties" : "Endocrinology",
"expansion" : "Study to Prevent NIDDM",
"statusUsableDate" : "2023-08-03",
"briefResultsDescription" : "Acarbose reduced the risk of diabetes",
"published" : "2002-06-15",
"pageName" : "STOP-NIDDM",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "STOP-NIDDM",
"title" : "Acarbose for prevention of type 2 diabetes mellitus",
"pmid" : "12086760"
},
{
"timestamp" : "2023-11-13T16:15:41Z",
"briefDesignDescription" : "Prednisolone vs. pentoxifylline in alcoholic hepatitis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1412278",
"pageid" : 2365,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1412278",
"trainingLevel" : "Intern",
"citation" : "Thursz MR, et al. \"Prednisolone or pentoxifylline for alcoholic hepatitis\". The New England Journal of Medicine. 2015. 372(17):1619-1628.",
"subspecialties" : "Gastroenterology",
"expansion" : "Steroids or Pentoxifylline for Alcoholic Hepatitis",
"statusUsableDate" : "2016-03-01",
"briefResultsDescription" : "No difference between groups",
"published" : "2015-04-23",
"pageName" : "STOPAH",
"diseases" : "Alcoholic Hepatitis",
"abbreviation" : "STOPAH",
"title" : "Prednisolone or pentoxifylline for alcoholic hepatitis",
"pmid" : "25901427"
},
{
"timestamp" : "2017-12-03T22:39:36Z",
"briefDesignDescription" : "Palliative statin discontinuation",
"fulltexturl" : "http://bit.ly/1LOZfB6",
"pageid" : 2432,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Kutner JS, et al. \"Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial\". JAMA Internal Medicine. 2015. 175(5):691-700.",
"subspecialties" : "Palliative Care;Cardiology",
"expansion" : "",
"statusUsableDate" : "2015-09-01",
"briefResultsDescription" : "Discontinuing statin doesn't change 60 day all-cause mortality",
"published" : "2015-05-01",
"pageName" : "Stopping Statins at the End of Life",
"diseases" : "Hyperlipidemia",
"abbreviation" : "",
"title" : "Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial",
"pmid" : "25798575"
},
{
"timestamp" : "2020-08-10T13:30:58Z",
"briefDesignDescription" : "Routine PPI use in the ICU",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1714919",
"pageid" : 3725,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1714919",
"trainingLevel" : "Resident",
"citation" : "Krag M, et al. \"Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU\". The New England Journal of Medicine. 2018. 379:2199-2208.",
"subspecialties" : "Critical Care",
"expansion" : "Stress Ulcer Prophylaxis in the Intensive Care Unit",
"statusUsableDate" : "2018-11-01",
"briefResultsDescription" : "PPI doesn't reduce mortality, it reduces bleeding",
"published" : "2018-10-24",
"pageName" : "SUP-ICU",
"diseases" : "Stress Ulcer Prophylaxis",
"abbreviation" : "SUP-ICU",
"title" : "Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU",
"pmid" : "30354950"
},
{
"timestamp" : "2017-12-03T22:39:31Z",
"briefDesignDescription" : "TAVI for AS in intermediate-risk surgical candidates",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700456",
"pageid" : 2895,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700456",
"trainingLevel" : "Resident",
"citation" : "Reardon MJ, et al. \"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients\". The New England Journal of Medicine. 2017. epub 2017-03-17:1-11.",
"subspecialties" : "Cardiology",
"expansion" : "Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement",
"statusUsableDate" : "2017-04-01",
"briefResultsDescription" : "TAVI noninferior to surgical AVR in intermediate-risk surgical candidates",
"published" : "2017-03-17",
"pageName" : "SURTAVI",
"diseases" : "Aortic Stenosis",
"abbreviation" : "SURTAVI",
"title" : "Surgical or transcatheter aortic-valve replacement in intermediate-risk patients",
"pmid" : "28304219"
},
{
"timestamp" : "2021-01-05T21:10:45Z",
"briefDesignDescription" : "Crizanlizumab vs. placebo in SCD",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1611770",
"pageid" : 4387,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1611770",
"trainingLevel" : "Fellow",
"citation" : "Ataga KI, et al. \"Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease\". The New England Journal of Medicine. 2017. 376(5):429-439.",
"subspecialties" : "Hematology",
"expansion" : "",
"statusUsableDate" : "2020-12-31",
"briefResultsDescription" : "Crizanlizumab reduces painful crises",
"published" : "2017-02-02",
"pageName" : "SUSTAIN",
"diseases" : "Sickle Cell Disease",
"abbreviation" : "SUSTAIN",
"title" : "Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease",
"pmid" : "27959701"
},
{
"timestamp" : "2023-11-22T22:00:48Z",
"briefDesignDescription" : "GLP-1 in DM if high CVD risk",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1607141",
"pageid" : 2882,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1607141",
"trainingLevel" : "Resident",
"citation" : "Marso SP, et al. \"Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes\". The New England Journal of Medicine. 2016. 375(18):1834-1844.",
"subspecialties" : "Cardiology;Endocrinology",
"expansion" : "Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes",
"statusUsableDate" : "2023-11-22",
"briefResultsDescription" : "GLP-1 lowers CVD events DM if high CVD risk",
"published" : "2016-11-10",
"pageName" : "SUSTAIN-6",
"diseases" : "Diabetes Mellitus;Cardiovascular Disease",
"abbreviation" : "SUSTAIN-6",
"title" : "Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes",
"pmid" : "27633186"
},
{
"timestamp" : "2023-02-16T20:42:11Z",
"briefDesignDescription" : "Mammogram screening 29y follow-up",
"fulltexturl" : "http://pubs.rsna.org/doi/10.1148/radiol.11110469",
"pageid" : 2435,
"pdfurl" : "http://pubs.rsna.org/doi/pdf/10.1148/radiol.11110469",
"trainingLevel" : "Student",
"citation" : "Tabar L, et al. \"Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades\". Radiology. 2011. 260(3):658-663.",
"subspecialties" : "Oncology;Preventive Medicine",
"expansion" : "",
"statusUsableDate" : "2023-02-16",
"briefResultsDescription" : "Breast cancer screening with mammogram lowers cancer mortality",
"published" : "2011-09-01",
"pageName" : "Swedish Two-County Trial",
"diseases" : "Breast Cancer",
"abbreviation" : "Swedish Two-County Trial",
"title" : "Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades",
"pmid" : "21712474"
},
{
"timestamp" : "2017-12-03T22:39:32Z",
"briefDesignDescription" : "Cytoreductive nephrectomy in metastatic RCC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa003013",
"pageid" : 1845,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa003013",
"trainingLevel" : "Fellow",
"citation" : "Flanigan RC, et al. \"Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer\". The New England Journal of Medicine. 2001. 345(23):1655-9.",
"subspecialties" : "Oncology;Surgery;Urology",
"expansion" : "",
"statusUsableDate" : "2014-06-01",
"briefResultsDescription" : "Cytoreductive nephrectomy improves survival in mRCC",
"published" : "2001-12-06",
"pageName" : "SWOG 8949",
"diseases" : "Renal Cell Carcinoma",
"abbreviation" : "SWOG 8949",
"title" : "Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer",
"pmid" : "11759643"
},
{
"timestamp" : "2013-03-05T21:40:49Z",
"briefDesignDescription" : "Symptom-triggered therapy in alcohol withdrawal",
"fulltexturl" : "http://archinte.ama-assn.org/cgi/content/full/162/10/1117",
"pageid" : 116,
"pdfurl" : "http://archinte.ama-assn.org/cgi/reprint/162/10/1117.pdf",
"trainingLevel" : "Intern",
"citation" : "Daeppen JB, et al. \"Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial\". Archives of Internal Medicine. 2002. 162(10):1117-21.",
"subspecialties" : "Psychiatry",
"expansion" : "",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Symptom-triggered therapy reduces length of hospitalization without increasing adverse event risk",
"published" : "2002-05-27",
"pageName" : "Symptom-Triggered Benzodiazepines in Alcohol Withdrawal",
"diseases" : "Alcohol Withdrawal",
"abbreviation" : "",
"title" : "Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial",
"pmid" : "12020181"
},
{
"timestamp" : "2017-12-03T22:39:33Z",
"briefDesignDescription" : "PCI vs. CABG in severe CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804626",
"pageid" : 525,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804626",
"trainingLevel" : "Resident",
"citation" : "Serruys PW, et al. \"Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease\". The New England Journal of Medicine. 2009. 360(10):961-972.",
"subspecialties" : "Cardiology;Surgery",
"expansion" : "Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery",
"statusUsableDate" : "2012-06-01",
"briefResultsDescription" : "CABG reduces major CV events with 3VD or LM disease",
"published" : "2009-03-05",
"pageName" : "SYNTAX",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "SYNTAX",
"title" : "Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease",
"pmid" : "19228612"
},
{
"timestamp" : "2020-04-01T00:34:11Z",
"briefDesignDescription" : "Early vs. Delayed PCI for UA-NSTEMI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200106213442501",
"pageid" : 2656,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200106213442501",
"trainingLevel" : "Resident",
"citation" : "Cannon CP, et al. \"Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban\". New England Journal of Medicine. 2001. 344(25):1879-1887.",
"subspecialties" : "Cardiology",
"expansion" : "Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban",
"statusUsableDate" : "2016-05-01",
"briefResultsDescription" : "Early PCI improves outcomes in high-risk patients",
"published" : "2001-06-21",
"pageName" : "TACTICS-TIMI 18",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "TACTICS-TIMI 18",
"title" : "Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban",
"pmid" : "11419424"
},
{
"timestamp" : "2017-12-03T22:39:38Z",
"briefDesignDescription" : "Tiotropium vs. others in asthma",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1008770",
"pageid" : 2267,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1008770",
"trainingLevel" : "Fellow",
"citation" : "Peters SP, et al. \"Tiotropium bromide step-up therapy for adults with uncontrolled asthma\". The New England Journal of Medicine. 2010. 363(18):1715-1726.",
"subspecialties" : "Pulmonology",
"expansion" : "Tiotropium Bromide as an Alternative to Increased Inhaled Glucocorticoid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid",
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Adding tiotropium improves peak expiratory flow better than doubling the ICS dose",
"published" : "2010-10-28",
"pageName" : "TALC",
"diseases" : "Asthma",
"abbreviation" : "TALC",
"title" : "Tiotropium bromide step-up therapy for adults with uncontrolled asthma",
"pmid" : "20979471"
},
{
"timestamp" : "2022-08-25T20:01:42Z",
"briefDesignDescription" : "Intensive vs. standard treatment in early RA",
"fulltexturl" : "https://doi.org/10.1016/s0140-6736(04)16676-2",
"pageid" : 2722,
"pdfurl" : "",
"trainingLevel" : "resident",
"citation" : "Grigor C, et al. \"Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial\". The Lancet. 2004. 364(9430):263-269.",
"subspecialties" : "Rheumatology",
"expansion" : "Tight Control of Rheumatoid Arthritis",
"statusUsableDate" : "2022-08-25",
"briefResultsDescription" : "Intensive treatment with better disease control than late RA",
"published" : "2004-07-17",
"pageName" : "TICORA",
"diseases" : "Rheumatoid Arthritis",
"abbreviation" : "TICORA",
"title" : "Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial",
"pmid" : "15262104"
},
{
"timestamp" : "2023-09-21T17:41:32Z",
"briefDesignDescription" : "Early vs. delayed PCI in NSTEMI and UA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807986",
"pageid" : 2867,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807986",
"trainingLevel" : "Resident",
"citation" : "Mehta SR, et al. \"Early versus Delayed Invasive Intervention in Acute Coronary Syndromes\". The New England Journal of Medicine. 2009. 360:2165-2175.",
"subspecialties" : "Cardiology",
"expansion" : "The Timing of Intervention in Acute Coronary Syndromes",
"statusUsableDate" : "2018-05-31",
"briefResultsDescription" : "Early PCI doesn't provide additional benefit over delayed PCI in NSTEMI and UA",
"published" : "2009-05-21",
"pageName" : "TIMACS",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"abbreviation" : "TIMACS",
"title" : "Early versus Delayed Invasive Intervention in Acute Coronary Syndromes",
"pmid" : "19458363"
},
{
"timestamp" : "2019-06-20T18:30:08Z",
"briefDesignDescription" : "Dalteparin in pregnant woman with thrombophilias",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60793-5",
"pageid" : 3718,
"pdfurl" : "https://reader.elsevier.com/reader/sd/pii/S0140673614607935",
"trainingLevel" : "Fellow",
"citation" : "Rodger MA, et al. \"Antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia\". Lancet. 2014. 384(9955):1673-1683.",
"subspecialties" : "Hematology;Obstetrics",
"expansion" : "Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia",
"statusUsableDate" : "2019-06-20",
"briefResultsDescription" : "Dalteparin did not reduce rate of pregnancy complications",
"published" : "2014-11-08",
"pageName" : "TIPPS",
"diseases" : "Thrombophilia;Pregnancy;Venous Thromboembolism",
"abbreviation" : "TIPPS",
"title" : "Antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia",
"pmid" : "25066248"
},
{
"timestamp" : "2017-12-14T19:37:07Z",
"briefDesignDescription" : "Atorvastatin in stable CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa050461",
"pageid" : 1762,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa050461",
"trainingLevel" : "Student",
"citation" : "LaRosa JC, et al. \"Intensive lipid lowering with atorvastatin in patients with stable coronary disease\". The New England Journal of Medicine. 2005. 352(14):1425-1435.",
"subspecialties" : "Cardiology",
"expansion" : "Treating to New Targets",
"statusUsableDate" : "2013-12-01",
"briefResultsDescription" : "Atorvastatin 80 mg better than 10 mg for major CV events in stable CAD",
"published" : "2005-04-07",
"pageName" : "TNT",
"diseases" : "Coronary Artery Disease;Hyperlipidemia",
"abbreviation" : "TNT",
"title" : "Intensive lipid lowering with atorvastatin in patients with stable coronary disease",
"pmid" : "15755765"
},
{
"timestamp" : "2017-12-14T19:36:29Z",
"briefDesignDescription" : "Na reduction and weight loss for HTN control in elderly",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/vol/279/pg/839",
"pageid" : 2990,
"pdfurl" : "",
"trainingLevel" : "Student",
"citation" : "Whelton PK, et al. \"Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group\". JAMA. 1998. 279(11):839-846.",
"subspecialties" : "Cardiology",
"expansion" : "Trial of Nonpharmacologic Interventions in the Elderly",
"statusUsableDate" : "2017-12-14",
"briefResultsDescription" : "Na reduction and weight loss are effective means for hypertension control in the elderly",
"published" : "1998-03-18",
"pageName" : "TONE",
"diseases" : "Hypertension",
"abbreviation" : "TONE",
"title" : "Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group",
"pmid" : "9515998"
},
{
"timestamp" : "2019-01-31T16:29:29Z",
"briefDesignDescription" : "Spironolactone for HFpEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313731",
"pageid" : 1797,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313731",
"trainingLevel" : "Resident",
"citation" : "Pitt B, et al. \"Spironolactone for heart failure with preserved ejection fraction\". The New England Journal of Medicine. 2014. 370(15):1383-1392.",
"subspecialties" : "Cardiology",
"expansion" : "Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist",
"statusUsableDate" : "2014-05-01",
"briefResultsDescription" : "Spironolactone doesn't reduce CV mortality, aborted cardiac arrest or HF hospitalizations in HFpEF",
"published" : "2014-04-20",
"pageName" : "TOPCAT",
"diseases" : "Heart Failure",
"abbreviation" : "TOPCAT",
"title" : "Spironolactone for heart failure with preserved ejection fraction",
"pmid" : "24716680"
},
{
"timestamp" : "2023-09-21T18:44:50Z",
"briefDesignDescription" : "Platelet transfusions in blood cancers",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212772",
"pageid" : 2794,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212772",
"trainingLevel" : "Resident",
"citation" : "Stanworth S, et al. \"A no-prophylaxis platelet-transfusion strategy for hematologic cancers\". The New England Journal of Medicine. 2013. 368(19):1771-1780.",
"subspecialties" : "Oncology;Hematology",
"expansion" : "Trial of Prophylactic Platelets",
"statusUsableDate" : "2023-09-22",
"briefResultsDescription" : "Prophylactic platelet transfusions lower bleeding events",
"published" : "2013-05-09",
"pageName" : "TOPPS",
"diseases" : "Thrombocytopenia",
"abbreviation" : "TOPPS",
"title" : "A no-prophylaxis platelet-transfusion strategy for hematologic cancers",
"pmid" : "23656642"
},
{
"timestamp" : "2015-05-29T16:40:40Z",
"briefDesignDescription" : "Salmeterol/fluticasone in COPD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa063070",
"pageid" : 124,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa063070",
"trainingLevel" : "Student",
"citation" : "Calverley PM, et al. \"Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease\". The New England Journal of Medicine. 2007. 356(8):775-789.",
"subspecialties" : "Pulmonology",
"expansion" : "Towards a Revolution in COPD Health",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Trend towards mortality benefit",
"published" : "2007-02-22",
"pageName" : "TORCH",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"abbreviation" : "TORCH",
"title" : "Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease",
"pmid" : "17314337"
},
{
"timestamp" : "2017-12-03T22:39:47Z",
"briefDesignDescription" : "Transfusion thresholds in UGIB",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211801",
"pageid" : 1191,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211801",
"trainingLevel" : "Intern",
"citation" : "Villanueva C et al. \"Transfusion strategies for acute upper gastrointestinal bleeding\". The New England Journal of Medicine. 2013. 368(1):11-21.",
"subspecialties" : "Gastroenterology",
"expansion" : "",
"statusUsableDate" : "2013-02-01",
"briefResultsDescription" : "Restrictive transfusions lower mortality in UGIB",
"published" : "2013-01-03",
"pageName" : "Transfusion Strategies for Acute Upper Gastrointestinal Bleeding",
"diseases" : "Gastrointestinal Hemorrhage;Hemorrhage",
"abbreviation" : "",
"title" : "Transfusion strategies for acute upper gastrointestinal bleeding",
"pmid" : "23281973"
},
{
"timestamp" : "2021-05-26T13:37:31Z",
"briefDesignDescription" : "Rivaroxaban in high-risk APLS",
"fulltexturl" : "https://doi.org/10.1182/blood-2018-04-848333",
"pageid" : 3700,
"pdfurl" : null,
"trainingLevel" : "Fellow",
"citation" : "Pengo V, et al. \"Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome\". Blood. 2018. 132(13):1365-1371.",
"subspecialties" : "Hematology;Rheumatology",
"expansion" : "Trial on Rivaroxaban in AntiPhospholipid Syndrome",
"statusUsableDate" : "2018-10-19",
"briefResultsDescription" : "Rivaroxaban inferior to warfarin in high-risk APLS",
"published" : "2018-09-27",
"pageName" : "TRAPS",
"diseases" : "Antiphospholipid Syndrome",
"abbreviation" : "TRAPS",
"title" : "Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome",
"pmid" : "30002145"
},
{
"timestamp" : "2015-03-09T17:49:43Z",
"briefDesignDescription" : "Darbepoetin in CKD and T2DM",
"fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907845",
"pageid" : 5,
"pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907845",
"trainingLevel" : "Resident",
"citation" : "Pfeffer MA, et al. \"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease\". The New England Journal of Medicine. 2009. 361(21):2019-32.",
"subspecialties" : "Nephrology;Hematology;Endocrinology",
"expansion" : "Trial to Reduce Cardiovascular Events With Aranesp Therapy",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No mortality benefit when targeting higher hemoglobin with ESAs in patients with CKD and T2DM",
"published" : "2009-11-19",
"pageName" : "TREAT",
"diseases" : "Chronic Kidney Disease;Anemia;Diabetes Mellitus",
"abbreviation" : "TREAT",
"title" : "A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease",
"pmid" : "19880844"
},
{
"timestamp" : "2019-06-27T20:30:21Z",
"briefDesignDescription" : "Withdrawal of medications in dilated cardiomyopathy",
"fulltexturl" : "https://doi.org/10.1016/S0140-6736(18)32484-X",
"pageid" : 3747,
"pdfurl" : "https://pdf.sciencedirectassets.com/271074/1-s2.0-S0140673618X00567/1-s2.0-S014067361832484X/main.pdf",
"trainingLevel" : "Resident",
"citation" : "Halliday BP, et al. \"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial\". The Lancet. 2019. 393(10166):61-73.",
"subspecialties" : "Cardiology",
"expansion" : "Treatment for heart failure in patients with recovered dilated cardiomyopathy",
"statusUsableDate" : "2019-06-20",
"briefResultsDescription" : "Withdrawal of medications increases relapse of heart failure",
"published" : "2018-11-09",
"pageName" : "TRED-HF",
"diseases" : "Heart Failure;Dilated Cardiomyopathy",
"abbreviation" : "TRED-HF",
"title" : "Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial",
"pmid" : "30429050"
},
{
"timestamp" : "2021-08-05T17:53:04Z",
"briefDesignDescription" : "Transfusion thresholds in ICU",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199902113400601",
"pageid" : 104,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199902113400601",
"trainingLevel" : "Intern",
"citation" : "Hebert PC, et al. \"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care\". The New England Journal of Medicine. 1999. 340(6):409-417.",
"subspecialties" : "Critical Care;Hematology;Transfusion Medicine",
"expansion" : "Transfusion Requirements in Critical Care",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Restrictive hemoglobin goals improved mortality",
"published" : "1999-02-11",
"pageName" : "TRICC",
"diseases" : "Anemia",
"abbreviation" : "TRICC",
"title" : "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care",
"pmid" : "9971864"
},
{
"timestamp" : "2018-04-26T17:40:38Z",
"briefDesignDescription" : "Transfusion thresholds for cardiac surgery",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711818",
"pageid" : 3536,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711818",
"trainingLevel" : "Resident",
"citation" : "Mazer CD, et al. \"Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery\". The New England Journal of Medicine. 2017. 377(22):2133-44.",
"subspecialties" : "Surgery;Hematology",
"expansion" : "Transfusion Requirements in Cardiac Surgery",
"statusUsableDate" : "2018-04-26",
"briefResultsDescription" : "Restrictive noninferior to liberal RBC transfusions",
"published" : "2017-11-30",
"pageName" : "TRICS III",
"diseases" : "Anemia",
"abbreviation" : "TRICS III",
"title" : "Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery",
"pmid" : "29130845"
},
{
"timestamp" : "2022-12-01T19:01:46Z",
"briefDesignDescription" : "Transfusion thresholds in sepsis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1406617",
"pageid" : 2268,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1406617",
"trainingLevel" : "Intern",
"citation" : "Holst L, et al. \"Transfusion thresholds in Septic Shock\". The New England Journal of Medicine. 2014. 371(15):1381-1391.",
"subspecialties" : "Critical Care;Hematology",
"expansion" : "Transfusion Requirements in Septic Shock",
"statusUsableDate" : "2014-12-01",
"briefResultsDescription" : "Similar mortality; Fewer transfusions with restrictive",
"published" : "2014-10-09",
"pageName" : "TRISS",
"diseases" : "Sepsis;Shock;Anemia",
"abbreviation" : "TRISS",
"title" : "Transfusion thresholds in Septic Shock",
"pmid" : "25270275"
},
{
"timestamp" : "2017-12-03T22:39:43Z",
"briefDesignDescription" : "Prasugrel vs. clopidogrel in ACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706482",
"pageid" : 1398,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482",
"trainingLevel" : "Resident",
"citation" : "Wiviott ST, et al. \"Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes\". The New England Journal of Medicine. 2007. 357(20):2001-2015.",
"subspecialties" : "Cardiology",
"expansion" : "Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel–Thrombolysis in Myocardial Infarction 38",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "Prasugrel decreases CV mortality/morbidity, increases bleeding",
"published" : "2007-11-15",
"pageName" : "TRITON-TIMI 38",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "TRITON-TIMI 38",
"title" : "Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes",
"pmid" : "17982182"
},
{
"timestamp" : "2017-12-03T22:39:45Z",
"briefDesignDescription" : "Eculizumab in PNH",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061648",
"pageid" : 2810,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061648",
"trainingLevel" : "Intern",
"citation" : "Hillmen P, et al. \"The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria\". The New England Journal of Medicine. 2006. 355(12):1233-1243.",
"subspecialties" : "Hematology",
"expansion" : "Transfusion Reduction Efficacy and Safety Clinical Investigation, a Randomized, Multicenter, Double-Blind, Placebo-Controlled, Using Eculizumab in Paroxysmal Nocturnal Hemoglobinuria",
"statusUsableDate" : "2017-08-01",
"briefResultsDescription" : "Eculizumab decreases transfusion requirements in PNH",
"published" : "2006-09-21",
"pageName" : "TRIUMPH",
"diseases" : "Paroxysmal Nocturnal Hemoglobinuria",
"abbreviation" : "TRIUMPH",
"title" : "The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria",
"pmid" : "16990386"
},
{
"timestamp" : "2017-12-03T22:39:46Z",
"briefDesignDescription" : "33 vs. 36°C body temperature after cardiac arrest",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310519",
"pageid" : 1783,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310519",
"trainingLevel" : "Resident",
"citation" : "Nielsen N, et al. \"Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest\". The New England Journal of Medicine. 2013. 369(23):2197-2206.",
"subspecialties" : "Cardiology;Neurology;Critical Care",
"expansion" : "Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest",
"statusUsableDate" : "2014-03-01",
"briefResultsDescription" : "33°C cooling provides no survival benefit over 36°C",
"published" : "2014-03-19",
"pageName" : "TTM",
"diseases" : "Cardiac Arrest",
"abbreviation" : "TTM",
"title" : "Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest",
"pmid" : "24237006"
},
{
"timestamp" : "2023-04-13T17:09:26Z",
"briefDesignDescription" : "33°C vs. normothermia after cardiac arrest",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2100591",
"pageid" : 4433,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2100591",
"trainingLevel" : "resident",
"citation" : "Dankiewicz J, et al. \"Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest\". The New England Journal of Medicine. 2021. 384(24):2283-2294.",
"subspecialties" : "Emergency Medicine;Critical Care;Cardiology",
"expansion" : "Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest 2",
"statusUsableDate" : "2021-07-30",
"briefResultsDescription" : "No difference in survival or functional outcomes",
"published" : "2021-06-17",
"pageName" : "TTM2",
"diseases" : "Cardiac Arrest",
"abbreviation" : "TTM2",
"title" : "Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest",
"pmid" : "34133859"
},
{
"timestamp" : "2017-12-03T22:39:48Z",
"briefDesignDescription" : "Twice-daily RT in limited SCLC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199901283400403",
"pageid" : 1773,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199901283400403",
"trainingLevel" : "Resident",
"citation" : "Turrisi AT, et al. \"Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide\". The New England Journal of Medicine. 1999. 340(4):265-271.",
"subspecialties" : "Oncology;Pulmonology;Radiation Oncology",
"expansion" : "",
"statusUsableDate" : "2013-12-01",
"briefResultsDescription" : "Twice-daily RT with better response, PFS, survival than once-daily RT for limited SCLC",
"published" : "1999-01-28",
"pageName" : "Twice-daily RT for SCLC",
"diseases" : "Lung Cancer",
"abbreviation" : "",
"title" : "Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide",
"pmid" : "9920950"
},
{
"timestamp" : "2023-09-22T22:59:11Z",
"briefDesignDescription" : "TXA vs. packing for antiplatelet agent-related epistaxis",
"fulltexturl" : "https://onlinelibrary.wiley.com/doi/abs/10.1111/acem.13345",
"pageid" : 3564,
"pdfurl" : "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.13345",
"trainingLevel" : "Student",
"citation" : "Zahed R. \"Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial\". Academic Emergency Medicine. 2018. 25(3):261-266.",
"subspecialties" : "Emergency Medicine",
"expansion" : "",
"statusUsableDate" : "2023-09-21",
"briefResultsDescription" : "TXA improved bleeding cessation time, rebleeding risk, and patient satisfaction",
"published" : "2018-03-01",
"pageName" : "TXA for Epistaxis Associated with Antiplatelet Agents",
"diseases" : "Epistaxis",
"abbreviation" : "",
"title" : "Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial",
"pmid" : "29125679"
},
{
"timestamp" : "2022-08-27T02:08:15Z",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140673698070196",
"pageid" : 253,
"pdfurl" : "",
"trainingLevel" : "Intern",
"citation" : "Turner R, et al. \"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes\". The Lancet. 1998. 352(9131):837-53.",
"subspecialties" : "Endocrinology",
"expansion" : "United Kingdom Prospective Diabetes Study",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Reduction in microvascular complications",
"published" : "1998-09-12",
"pageName" : "UKPDS 33",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "UKPDS",
"title" : "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes",
"pmid" : "9742976"
},
{
"timestamp" : "2017-12-03T22:39:50Z",
"briefDesignDescription" : "Metformin in T2DM",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2898%2907037-8/fulltext",
"pageid" : 1747,
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673698070378.pdf",
"trainingLevel" : "Intern",
"citation" : "UKPDS Study Group. \"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.\". The Lancet. 1998. 352(9131):854-865.",
"subspecialties" : "Endocrinology",
"expansion" : "UK Prospective Diabetes Study 34",
"statusUsableDate" : "2014-01-01",
"briefResultsDescription" : "Metformin better than diet alone in T2DM",
"published" : "1998-11-07",
"pageName" : "UKPDS 34",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "UKPDS 34",
"title" : "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.",
"pmid" : "9742977"
},
{
"timestamp" : "2012-10-29T23:28:48Z",
"briefDesignDescription" : "Tiotropium in COPD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805800",
"pageid" : 123,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805800",
"trainingLevel" : "Resident",
"citation" : "Tashkin DP, et al. \"A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease\". The New England Journal of Medicine. 2008. 395(15):1543-1554.",
"subspecialties" : "Pulmonology",
"expansion" : "Understanding Potential Long-Term Impacts on Function with Tiotropium",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Decreased exacerbations and mortality",
"published" : "2008-10-09",
"pageName" : "UPLIFT",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"abbreviation" : "UPLIFT",
"title" : "A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease",
"pmid" : "18836213"
},
{
"timestamp" : "2017-12-03T22:39:51Z",
"briefDesignDescription" : "ISDN/hydralazine in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198606123142404",
"pageid" : 155,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198606123142404",
"trainingLevel" : "student",
"citation" : "Cohn JN, et al. \"Effect of vasodilator therapy on mortality in chronic congestive heart failure\". The New England Journal of Medicine. 1986. 314(24):1547-52.",
"subspecialties" : "Cardiology",
"expansion" : "Vasodilator Heart Failure Trial",
"statusUsableDate" : "2012-12-01",
"briefResultsDescription" : "Trend towards mortality benefit in ISDN/hydralazine",
"published" : "1986-06-12",
"pageName" : "V-HeFT",
"diseases" : "Heart Failure",
"abbreviation" : "V-HeFT",
"title" : "Effect of vasodilator therapy on mortality in chronic congestive heart failure",
"pmid" : "3520315"
},
{
"timestamp" : "2018-04-13T13:08:04Z",
"briefDesignDescription" : "Enalapril vs. ISDN/hydralazine in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199108013250502",
"pageid" : 2943,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199108013250502",
"trainingLevel" : "Student",
"citation" : "Cohn JN, et al. \"A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure\". The New England Journal of Medicine. 1991. 325(5):303-310.",
"subspecialties" : "Cardiology",
"expansion" : "Vasodilator Heart Failure Trial II",
"statusUsableDate" : "2017-11-01",
"briefResultsDescription" : "Enalapril improves survival in HFrEF",
"published" : "1991-08-01",
"pageName" : "V-HeFT II",
"diseases" : "Heart Failure",
"abbreviation" : "V-HeFT II",
"title" : "A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure",
"pmid" : "2057035"
},
{
"timestamp" : "2014-09-24T22:23:54Z",
"briefDesignDescription" : "Aspirin in unstable angina",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198308183090703",
"pageid" : 261,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198308183090703",
"trainingLevel" : "Resident",
"citation" : "Lewis HD, et al. \"Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study\". The New England Journal of Medicine. 1983. 309(7):396-403.",
"subspecialties" : "Cardiology",
"expansion" : null,
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Aspirin decreases mortality",
"published" : "1983-08-18",
"pageName" : "VA Cooperative Study",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : null,
"title" : "Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study",
"pmid" : "6135989"
},
{
"timestamp" : "2018-01-11T18:14:18Z",
"briefDesignDescription" : "ACE+ARB in DM nephropathy",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1303154",
"pageid" : 1798,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1303154",
"trainingLevel" : "Resident",
"citation" : "Fried LF, et al. \"Combined angiotensin inhibition for the treatment of diabetic nephropathy\". The New England Journal of Medicine. 2013. 369(20):1892-1903.",
"subspecialties" : "Nephrology;Endocrinology",
"expansion" : "Veterans Affairs Nephropathy in Diabetes",
"statusUsableDate" : "2014-05-01",
"briefResultsDescription" : "ACE+ARB no more effective than monotherapy, increases complications",
"published" : "2013-11-14",
"pageName" : "VA-NEPHRON D",
"diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
"abbreviation" : "VA NEPHRON-D",
"title" : "Combined angiotensin inhibition for the treatment of diabetic nephropathy",
"pmid" : "24206457"
},
{
"timestamp" : "2018-08-12T16:18:00Z",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0808431",
"pageid" : 254,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0808431",
"trainingLevel" : "Resident",
"citation" : "Duckworth W, et al. \"Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes\". The New England Journal of Medicine. 2009. 360(2):129-39.",
"subspecialties" : "Endocrinology",
"expansion" : "Veterans Affairs Diabetes Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No effect on macrovascular or severe microvascular outcomes",
"published" : "2009-01-08",
"pageName" : "VADT",
"diseases" : "Diabetes Mellitus",
"abbreviation" : "VADT",
"title" : "Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes",
"pmid" : "19092145"
},
{
"timestamp" : "2014-08-24T17:55:57Z",
"briefDesignDescription" : "Valsartan in HFrEF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010713",
"pageid" : 20,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010713",
"trainingLevel" : "Resident",
"citation" : "Cohn JN, et al. \"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure\". New England Journal of Medicine. 2001. 345(23):1667-75.",
"subspecialties" : "Cardiology",
"expansion" : "Valsartan Heart Failure Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No mortality benefit of valsartan in NYHA II-IV HF",
"published" : "2001-12-06",
"pageName" : "Val-HeFT",
"diseases" : "Heart Failure",
"abbreviation" : "Val-HeFT",
"title" : "A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure",
"pmid" : "11759645"
},
{
"timestamp" : "2017-12-03T22:39:54Z",
"briefDesignDescription" : "Sofosbuvir+ribavirin for HCV genotypes 2 or 3",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1316145",
"pageid" : 2261,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1316145",
"trainingLevel" : "Student",
"citation" : "Zeuzem S, et al. \"Sofosbuvir and ribavirin in HCV genotypes 2 and 3\". The New England Journal of Medicine. 2014. 370(21):1993-2001.",
"subspecialties" : "Infectious Disease;Gastroenterology",
"expansion" : "",
"statusUsableDate" : "2014-12-01",
"briefResultsDescription" : "Sofosbuvir+ribavirin effective without IFN",
"published" : "2014-05-22",
"pageName" : "VALENCE",
"diseases" : "Hepatitis C",
"abbreviation" : "VALENCE",
"title" : "Sofosbuvir and ribavirin in HCV genotypes 2 and 3",
"pmid" : "24795201"
},
{
"timestamp" : "2019-04-11T17:06:09Z",
"briefDesignDescription" : "Valsartan vs. captopril in MI with LV dysfunction",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa032292",
"pageid" : 462,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa032292",
"trainingLevel" : "Resident",
"citation" : "Pfeffer MA, et al. \"Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both\". The New England Journal of Medicine. 2003. 349(20):1893-1903.",
"subspecialties" : "Cardiology",
"expansion" : "Valsartan in Acute Myocardial Infarction Trial",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Valsartan as effective as captopril",
"published" : "2003-11-13",
"pageName" : "VALIANT",
"diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
"abbreviation" : "VALIANT",
"title" : "Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both",
"pmid" : "12921816"
},
{
"timestamp" : "2014-07-28T20:00:24Z",
"briefDesignDescription" : "Vancomycin vs. metronidazole in C. difficile",
"fulltexturl" : "http://cid.oxfordjournals.org/content/45/3/302.long",
"pageid" : 6,
"pdfurl" : "http://cid.oxfordjournals.org/content/45/3/302.full.pdf",
"trainingLevel" : "Intern",
"citation" : "Zar FA, et al. \"A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity\". Clinical Infectious Diseases. 2007. 45(3):302-7.",
"subspecialties" : "Infectious Disease;Gastroenterology",
"expansion" : null,
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Vancomycin is superior to metronidazole in severe C. difficile-associated diarrhea",
"published" : "2007-08-01",
"pageName" : "Vancomycin vs. Metronidazole in C. difficile Diarrhea",
"diseases" : "Clostridium difficile",
"abbreviation" : null,
"title" : "A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity",
"pmid" : "17599306"
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{
"timestamp" : "2017-12-03T22:39:56Z",
"briefDesignDescription" : "Ablation vs. antiarrhythmic drugs in VT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1513614",
"pageid" : 2783,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1513614",
"trainingLevel" : "Resident",
"citation" : "Sapp JL, et al. \"Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs\". The New England Journal of Medicine. 2016. 375(2):111-121.",
"subspecialties" : "Cardiology",
"expansion" : "Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs",
"statusUsableDate" : "2016-06-01",
"briefResultsDescription" : "VT ablation superior to escalation of antiarrhythmic drugs",
"published" : "2016-05-05",
"pageName" : "VANISH",
"diseases" : "Ventricular Tachycardia",
"abbreviation" : "VANISH",
"title" : "Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs",
"pmid" : "27149033"
},
{
"timestamp" : "2020-11-22T18:00:12Z",
"briefDesignDescription" : "Vasopressin in septic shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067373",
"pageid" : 1910,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067373",
"trainingLevel" : "Resident",
"citation" : "Russel JA, et al. \"Vasopressin versus norepinephrine infusion in patients with septic shock\". The New England Journal of Medicine. 2008. 358(9):877-887.",
"subspecialties" : "Critical Care",
"expansion" : "Vasopressin and Septic Shock Trial",
"statusUsableDate" : "2014-08-01",
"briefResultsDescription" : "Vasopressin doesn't reduce mortality in shock",
"published" : "2008-02-28",
"pageName" : "VASST",
"diseases" : "Sepsis;Shock",
"abbreviation" : "VASST",
"title" : "Vasopressin versus norepinephrine infusion in patients with septic shock",
"pmid" : "18305265"
},
{
"timestamp" : "2019-10-17T17:47:55Z",
"briefDesignDescription" : "Wearable cardioverter-defibrillator post-MI",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800781",
"pageid" : 3716,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800781",
"trainingLevel" : "Resident",
"citation" : "Olgin JE, et al. \"Wearable cardioverter-defibrillator after myocardial infarction\". The New England Journal of Medicine. 2018. 379(13):1205-1215.",
"subspecialties" : "Cardiology",
"expansion" : "Vest Prevention of Early Sudden Death",
"statusUsableDate" : "2018-10-11",
"briefResultsDescription" : "Wearable cardioverter-defibrillator doesn't reduce arrhythmic death",
"published" : "2018-09-27",
"pageName" : "VEST",
"diseases" : "Sudden Cardiac Death",
"abbreviation" : "VEST",
"title" : "Wearable cardioverter-defibrillator after myocardial infarction",
"pmid" : "30280654"
},
{
"timestamp" : "2022-12-21T16:29:52Z",
"briefDesignDescription" : "Antiepileptics in status epilepticus",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199809173391202",
"pageid" : 2461,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJM199809173391202",
"trainingLevel" : "Intern",
"citation" : "Veterans Affairs Status Epilepticus Cooperative Study Group. \"A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus\". New England Journal of Medicine. 1998. 339(12):792-798.",
"subspecialties" : "Neurology",
"expansion" : "",
"statusUsableDate" : "2022-12-20",
"briefResultsDescription" : "No difference between four antiepileptics",
"published" : "1998-09-17",
"pageName" : "Veterans Affairs Status Epilepticus Cooperative Study Group",
"diseases" : "Epilepsy",
"abbreviation" : "Veterans Affairs Status Epilepticus Study",
"title" : "A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus",
"pmid" : "9738086"
},
{
"timestamp" : "2024-02-22T20:28:09Z",
"briefDesignDescription" : "Omega-3 FA for CV and cancer prevention",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1811403",
"pageid" : 4179,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1811403",
"trainingLevel" : "resident",
"citation" : "Manson JE, et al. \"Marine n-3 fatty acids and prevention of cardiovascular disease and cancer\". The New England Journal of Medicine. 2019. 2019(380):1.",
"subspecialties" : "Cardiology;Oncology",
"expansion" : "Vitamin D and Omega-3 Trial",
"statusUsableDate" : "2024-02-22",
"briefResultsDescription" : "Omega-3 FA did not lower CV or cancer events",
"published" : "2019-01-03",
"pageName" : "VITAL (Omega-3 arm)",
"diseases" : "Cardiovascular Disease;Cancer",
"abbreviation" : "VITAL",
"title" : "Marine n-3 fatty acids and prevention of cardiovascular disease and cancer",
"pmid" : "30415637"
},
{
"timestamp" : "2022-12-15T19:57:40Z",
"briefDesignDescription" : "Vitamin D for cancer or CVD prevention",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa1809944",
"pageid" : 4039,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1809944",
"trainingLevel" : "resident",
"citation" : "Manson JE, et al. \"Vitamin D supplements and prevention of cancer and cardiovascular disease\". The New England Journal of Medicine. 2019. 380(1):33-44.",
"subspecialties" : "Cardiology;Oncology",
"expansion" : "VITamin D and OmegA-3 TriaL",
"statusUsableDate" : "2022-12-14",
"briefResultsDescription" : "Vitamin D doesn't lower cancer or CVD risk",
"published" : "2019-01-03",
"pageName" : "VITAL (Vitamin D arm)",
"diseases" : "Cardiovascular Disease;Cancer",
"abbreviation" : "VITAL",
"title" : "Vitamin D supplements and prevention of cancer and cardiovascular disease",
"pmid" : "30415629"
},
{
"timestamp" : "2023-11-22T21:13:36Z",
"briefDesignDescription" : "Vitamin C, hydrocortisone, & thiamine in septic shock",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.22176",
"pageid" : 4192,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Fujii T, et al. \"Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial\". JAMA. 2020. 323(5):423-431.",
"subspecialties" : "Critical Care",
"expansion" : "The VitamIn C, HydrocorTisone and ThiAMINe in Patients With Septic Shock Trial",
"statusUsableDate" : "2020-09-03",
"briefResultsDescription" : "No difference with triple-therapy in septic shock",
"published" : "2020-02-04",
"pageName" : "VITAMINS",
"diseases" : "Septic Shock",
"abbreviation" : "VITAMINS",
"title" : "Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial",
"pmid" : "31950979"
},
{
"timestamp" : "2023-05-18T18:04:42Z",
"briefDesignDescription" : "Rivaroxaban 2.5mg BID in PAD",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2000052",
"pageid" : 5305,
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2000052",
"trainingLevel" : "resident",
"citation" : "Bonaca M, et al. \"Rivaroxaban in Peripheral Artery Disease after Revascularization\". The New England Journal of Medicine. 2020. 382(21):1994-2004.",
"subspecialties" : "Cardiology",
"expansion" : null,
"statusUsableDate" : "2023-04-20",
"briefResultsDescription" : "Low-dose rivaroxaban lowers PAD events",
"published" : "2020-05-21",
"pageName" : "VOYAGER-PAD",
"diseases" : "Peripheral Artery Disease",
"abbreviation" : "VOYAGER",
"title" : "Rivaroxaban in Peripheral Artery Disease after Revascularization",
"pmid" : "32222135"
},
{
"timestamp" : "2017-12-03T22:39:59Z",
"briefDesignDescription" : "Aspirin after VTE treatment",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1114238",
"pageid" : 1244,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1114238",
"trainingLevel" : "resident",
"citation" : "Becattini C, et al. \"Aspirin for preventing the recurrence of venous thromboembolism\". The New England Journal of Medicine. 2012. 366(21):1959-1967.",
"subspecialties" : "Hematology",
"expansion" : "Warfarin and Aspirin",
"statusUsableDate" : "2013-03-01",
"briefResultsDescription" : "Aspirin reduces recurrent VTE",
"published" : "2012-05-24",
"pageName" : "WARFASA",
"diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
"abbreviation" : "WARFASA",
"title" : "Aspirin for preventing the recurrence of venous thromboembolism",
"pmid" : "22621626"
},
{
"timestamp" : "2022-03-10T20:02:17Z",
"briefDesignDescription" : "Aspirin vs. warfarin in ischemic stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011258",
"pageid" : 2784,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011258",
"trainingLevel" : "Intern",
"citation" : "Mohr J, et al. \"A Comparison of Warfarin and Aspirin for the Prevention of Recurrent Ischemic Stroke\". The New England Journal of Medicine. 2001. 345(20):1444-1451.",
"subspecialties" : "Neurology",
"expansion" : "Warfarin–Aspirin Recurrent Stroke Study",
"statusUsableDate" : "2022-03-10",
"briefResultsDescription" : "Warfarin did not reduce rates of death/stroke, caused more bleeding",
"published" : "2001-11-15",
"pageName" : "WARSS",
"diseases" : "Stroke",
"abbreviation" : "WARSS",
"title" : "A Comparison of Warfarin and Aspirin for the Prevention of Recurrent Ischemic Stroke",
"pmid" : "11794192"
},
{
"timestamp" : "2019-06-27T17:24:44Z",
"briefDesignDescription" : "Warfarin vs. aspirin for intracranial atherosclerosis",
"fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043033",
"pageid" : 2427,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043033",
"trainingLevel" : "Intern",
"citation" : "Chimowitz MI, et al. \"Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis\". The New England Journal of Medicine. 2005. 352(13):1305-1306.",
"subspecialties" : "Neurology;Cardiology",
"expansion" : "Warfarin-Aspirin Symptomatic Intracranial Disease",
"statusUsableDate" : "2019-06-27",
"briefResultsDescription" : "Warfarin had higher adverse events",
"published" : "2005-03-31",
"pageName" : "WASID",
"diseases" : "Stroke",
"abbreviation" : "WASID",
"title" : "Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis",
"pmid" : "15800226"
},
{
"timestamp" : "2017-12-03T22:40:01Z",
"briefDesignDescription" : "Postmenopausal estrogen/progesterone",
"fulltexturl" : null,
"pageid" : 1507,
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4840/JOC21036.pdf",
"trainingLevel" : "Student",
"citation" : "Rossouw JE, et al. \"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial\". The Journal of the American Medical Association. 2002. 288(3):321-333.",
"subspecialties" : "Gynecology;Endocrinology",
"expansion" : "Women's Health Initiative Estrogen and Progestin Trial",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Postmenopausal estrogen/progesterone HRT increases rates of MI and breast cancer",
"published" : "2002-07-17",
"pageName" : "WHI",
"diseases" : "Coronary Artery Disease;Menopause",
"abbreviation" : "WHI E+P",
"title" : "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial",
"pmid" : "12117397"
},
{
"timestamp" : "2017-12-03T22:40:03Z",
"briefDesignDescription" : "ICS withdrawal in COPD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407154",
"pageid" : 2318,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407154",
"trainingLevel" : "Resident",
"citation" : "Magnussen H, et al. \"Withdrawal of inhaled glucocorticoids and exacerbations of COPD\". The New England Journal of Medicine. 2014. 371(14):1285-1295.",
"subspecialties" : "Pulmonology",
"expansion" : "Withdrawal of Inhaled Steroids during Optimized Bronchodilator Management",
"statusUsableDate" : "2015-05-01",
"briefResultsDescription" : "ICS withdrawal may reduce FEV1, no change in COPD flares",
"published" : "2014-10-02",
"pageName" : "WISDOM",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"abbreviation" : "WISDOM",
"title" : "Withdrawal of inhaled glucocorticoids and exacerbations of COPD",
"pmid" : "25196117"
},
{
"timestamp" : "2017-12-03T22:40:05Z",
"briefDesignDescription" : "Clopidogrel ± ASA after PCI if on OAC",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0140673612621771",
"pageid" : 1792,
"pdfurl" : "",
"trainingLevel" : "Resident",
"citation" : "Dewilde WJM, et al. \"Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial\". The Lancet. 2013. 381(9872):1107-1115.",
"subspecialties" : "Cardiology;Hematology",
"expansion" : "What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing",
"statusUsableDate" : "2015-06-01",
"briefResultsDescription" : "ASA increases bleeding when added to clopidogrel if chronic OAC",
"published" : "2013-03-30",
"pageName" : "WOEST",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "WOEST",
"title" : "Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial",
"pmid" : "23415013"
},
{
"timestamp" : "2014-12-12T19:39:51Z",
"briefDesignDescription" : "Pravastatin in CAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199511163332001",
"pageid" : 172,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199511163332001",
"trainingLevel" : "Resident",
"citation" : "Shepherd J, et al. \"Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia\". The New England Journal of Medicine. 1995. 333(20):1301-1308.",
"subspecialties" : "Cardiology",
"expansion" : "West of Scotland Coronary Prevention Study",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Pravastatin reduces MIs and CV mortality",
"published" : "1995-11-16",
"pageName" : "WOSCOPS",
"diseases" : "Hyperlipidemia;Coronary Artery Disease",
"abbreviation" : "WOSCOPS",
"title" : "Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia",
"pmid" : "7566020"
},
{
"timestamp" : "2017-12-03T22:40:06Z",
"briefDesignDescription" : "RSBI for predicting weaning",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199105233242101",
"pageid" : 75,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199105233242101",
"trainingLevel" : "Resident",
"citation" : "Yang KL, Tobin MJ. \"A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation\". The New England Journal of Medicine. 1991. 324(21):1445-1450.",
"subspecialties" : "Pulmonology;Critical Care",
"expansion" : "",
"statusUsableDate" : "2013-01-01",
"briefResultsDescription" : "RSBI predicts success and failure of weaning from mechanical ventilation",
"published" : "1991-05-23",
"pageName" : "Yang-Tobin Study",
"diseases" : "Critical Illness",
"abbreviation" : "",
"title" : "A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation",
"pmid" : "2023603"
}
]
}
}