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{
"articlesQuery" : {
"articles" : [
{
"trainingLevel" : "Resident",
"abbreviation" : "3C",
"briefDesignDescription" : "Antibiotic strategies in lower respiratory tract infections",
"subspecialties" : "Infectious Disease;Pulmonology",
"timestamp" : "2019-09-12T17:46:55Z",
"pageid" : 2956,
"statusUsableDate" : "2019-09-12",
"diseases" : "Pneumonia",
"briefResultsDescription" : "Similar outcomes in upfront, delayed, and no antibiotic strategies",
"expansion" : "Cough Complication Cohort",
"published" : "2017-05-22",
"fulltexturl" : "https://www.bmj.com/content/357/bmj.j2148.long",
"pageName" : "3C",
"citation" : "Little P, et al. \"Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study\". The British Medical Journal. 2017. 357:j2148.",
"title" : "Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study",
"pdfurl" : "https://www.bmj.com/content/bmj/357/bmj.j2148.full.pdf",
"pmid" : "28533265"
},
{
"subspecialties" : "Critical Care;Infectious Disease",
"timestamp" : "2017-12-03T22:32:58Z",
"pageid" : 2479,
"trainingLevel" : "Student",
"briefDesignDescription" : "Central line complications by insertion site",
"abbreviation" : "3SITES",
"diseases" : "Critical Illness;Catheter-Related Bloodstream Infection",
"briefResultsDescription" : "Subclavian lines yield fewer CRBSIs and DVTs compared to IJ/femoral lines",
"statusUsableDate" : "2015-11-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500964",
"pageName" : "3SITES",
"expansion" : "",
"published" : "2015-09-24",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500964",
"pmid" : "26398070",
"citation" : "Parienti JJ, et al. \"Intravascular Complications of Central Venous Catheterization by Insertion Site\". The New England Journal of Medicine. 2015. 373(13):1220-1229.",
"title" : "Intravascular Complications of Central Venous Catheterization by Insertion Site"
},
{
"published" : "1994-11-19",
"expansion" : "Scandinavian Simvastatin Survival Study",
"pageName" : "4S",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)90566-5/abstract",
"title" : "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)",
"citation" : "Pedersen TR, et al. \"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)\". The Lancet. 1994. 344(8934):1383-1389.",
"pmid" : "7968073",
"pdfurl" : "",
"briefDesignDescription" : "Simvastatin in stable CAD",
"abbreviation" : "4S",
"trainingLevel" : "Student",
"pageid" : 1587,
"timestamp" : "2017-12-14T19:22:25Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Simvastatin reduces all mortality in stable CAD",
"diseases" : "Hyperlipidemia;Coronary Artery Disease"
},
{
"subspecialties" : "Critical Care;Neurology;Geriatrics",
"timestamp" : "2021-08-21T01:56:39Z",
"pageid" : 4436,
"trainingLevel" : "resident",
"abbreviation" : "65 Trial",
"briefDesignDescription" : "MAP 60-65 vs. usual care in vasodilatory hypotension in ICU",
"diseases" : "Hypotension",
"briefResultsDescription" : "No difference in mortality between groups",
"statusUsableDate" : "2021-08-19",
"fulltexturl" : "https://doi.org/10.1001/jama.2020.0930",
"pageName" : "65 Trial",
"published" : "2020-02-12",
"expansion" : "",
"pdfurl" : "",
"pmid" : "32049269",
"citation" : "Lamontagne F, et al. \"Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension; A Randomized Clinical Trial\". JAMA. 2020. 323(10):938-949.",
"title" : "Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension; A Randomized Clinical Trial"
},
{
"pageName" : "A-HeFT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa042934",
"expansion" : "African-American Heart Failure Trial",
"published" : "2004-11-11",
"pmid" : "15533851",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa042934",
"title" : "Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure",
"citation" : "Taylor AL, et al. \"Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure\". The New England Journal of Medicine. 2004. 351(20):2049-2057.",
"pageid" : 41,
"timestamp" : "2019-02-22T06:12:34Z",
"subspecialties" : "Cardiology",
"briefDesignDescription" : "ISDN/hydralazine for black patients with HFrEF",
"abbreviation" : "A-HeFT",
"trainingLevel" : "Student",
"briefResultsDescription" : "Improved survival among black patients with HF",
"diseases" : "Heart Failure",
"statusUsableDate" : "2012-03-01"
},
{
"citation" : "Wright JT Jr., et al. \"Intensive blood-pressure control in hypertensive chronic kidney disease\". JAMA. 2002. 288(19):2421-2431.",
"title" : "Intensive blood-pressure control in hypertensive chronic kidney disease",
"pmid" : "12435255",
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/195530/joc20772.pdf",
"published" : "2002-11-20",
"expansion" : "African American Study of Kidney Disease and Hypertension",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/195530",
"pageName" : "AASK",
"statusUsableDate" : "2019-08-29",
"briefResultsDescription" : "Intensive BP control didn't prevent progression of kidney disease but ACE-inhibitors did",
"diseases" : "Chronic Kidney Disease;Hypertension",
"trainingLevel" : "Intern",
"abbreviation" : "AASK",
"briefDesignDescription" : "BP management for CKD in African Americans",
"subspecialties" : "Nephrology",
"pageid" : 2666,
"timestamp" : "2019-10-29T18:24:45Z"
},
{
"citation" : "Di Biase et al. \"Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device\". Circulation. 2016. 133(17):1637-1634.",
"title" : "Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device",
"pdfurl" : null,
"pmid" : "27029350",
"published" : "2016-04-26",
"expansion" : "Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device",
"fulltexturl" : "http://circ.ahajournals.org/content/early/2016/03/30/CIRCULATIONAHA.115.019406",
"pageName" : "AATAC",
"statusUsableDate" : "2016-09-01",
"diseases" : "Atrial Fibrillation;Heart Failure",
"briefResultsDescription" : "AF ablation superior to amiodarone in HFrEF with LVEF ≤40%",
"trainingLevel" : "Resident",
"abbreviation" : "AATAC",
"briefDesignDescription" : "AF ablation vs. amiodarone in HFrEF with LVEF ≤40%",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:33:01Z",
"pageid" : 2829
},
{
"trainingLevel" : "Student",
"abbreviation" : "ACAS",
"briefDesignDescription" : "CEA vs. medical therapy in asymptomatic carotid stenosis",
"subspecialties" : "Surgery;Neurology;Cardiology",
"timestamp" : "2025-05-29T18:18:33Z",
"pageid" : 4279,
"statusUsableDate" : "2025-05-29",
"diseases" : "Carotid Stenosis;Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "CEA reduced stroke/death rate compared to medical management",
"published" : "1995-05-10",
"expansion" : "Asymptomatic Carotid Artery Stenosis Trial",
"fulltexturl" : "https://jamanetwork.com/journals/jama/article-abstract/388335",
"pageName" : "ACAS",
"citation" : "Micheal Walker, et al. \"Endarterectomy for Asymptomatic Carotid Artery Stenosis\". Journal of the American Medical Association. 1995. 273(18):1421-1428.",
"title" : "Endarterectomy for Asymptomatic Carotid Artery Stenosis",
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/388335/jama_273_18_035.pdf",
"pmid" : "7723155"
},
{
"trainingLevel" : "Resident",
"abbreviation" : "ACCOMPLISH",
"briefDesignDescription" : "Benazepril/amlodipine vs. benazepril/HCTZ in HTN",
"subspecialties" : "Cardiology",
"pageid" : 1448,
"timestamp" : "2018-01-11T18:23:02Z",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Benazepril/amlodipine is associated with fewer CV events",
"diseases" : "Hypertension",
"published" : "2008-12-04",
"expansion" : "Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0806182",
"pageName" : "ACCOMPLISH",
"citation" : "Jamerson K, et al. \"Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients\". The New England Journal of Medicine. 2008. 359(23):2417-2428.",
"title" : "Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients",
"pmid" : "19052124",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0806182"
},
{
"statusUsableDate" : "2012-03-01",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Increased mortality and no cardiovascular benefit with intensive glycemic control",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"abbreviation" : "ACCORD",
"trainingLevel" : "Intern",
"timestamp" : "2019-12-18T14:23:33Z",
"pageid" : 105,
"subspecialties" : "Endocrinology",
"title" : "Effects of Intensive Glucose Lowering in Type 2 Diabetes",
"citation" : "Gerstein HC, et al. \"Effects of Intensive Glucose Lowering in Type 2 Diabetes\". The New England Journal of Medicine. 2008. 358(24):2545-59.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802743",
"pmid" : "18539917",
"published" : "2008-06-12",
"expansion" : "Action to Control Cardiovascular Risk in Diabetes",
"pageName" : "ACCORD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802743"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001286",
"pageName" : "ACCORD BP",
"published" : "2010-03-14",
"expansion" : "ACCORD Study Group",
"pmid" : "20228401",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001286",
"citation" : "ACCORD Study Group. \"Effects of intensive blood-pressure control in type 2 diabetes mellitus\". The New England Journal of Medicine. 2010. 362(17):1575-1585.",
"title" : "Effects of intensive blood-pressure control in type 2 diabetes mellitus",
"subspecialties" : "Endocrinology",
"pageid" : 1760,
"timestamp" : "2024-12-12T20:32:12Z",
"trainingLevel" : "Student",
"briefDesignDescription" : "Intensive BP control in T2DM",
"abbreviation" : "ACCORD BP",
"briefResultsDescription" : "Intensive BP control doesn't reduce CV events in T2DM",
"diseases" : "Diabetes Mellitus;Hypertension",
"statusUsableDate" : "2014-08-01"
},
{
"timestamp" : "2018-01-31T01:55:15Z",
"pageid" : 3520,
"subspecialties" : "Cardiology;Endocrinology",
"abbreviation" : "ACCORD Lipid",
"briefDesignDescription" : "Fibrate add-on to statins in T2DM",
"trainingLevel" : "Student",
"diseases" : "Diabetes Mellitus;Coronary Artery Disease;Stroke",
"briefResultsDescription" : "Fenofibrates don't reduce CVD among adults with T2DM on statins",
"statusUsableDate" : "2018-01-17",
"pageName" : "ACCORD Lipid",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001282",
"expansion" : "Action to Control Cardiovascular Risk in Diabetes-Lipid",
"published" : "2010-04-29",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001282",
"pmid" : "20228404",
"title" : "Effects of combination lipid therapy in type 2 diabetes mellitus",
"citation" : "ACCORD Study Group. \"Effects of combination lipid therapy in type 2 diabetes mellitus\". The New England Journal of Medicine. 2010. 362(17):1563-1574."
},
{
"subspecialties" : "Infectious Disease;Critical Care;Emergency Medicine",
"pageid" : 5478,
"timestamp" : "2024-03-28T17:22:37Z",
"trainingLevel" : "Resident",
"abbreviation" : "ACORN",
"briefDesignDescription" : "Empiric cefepime vs. pip-tazo for infection",
"briefResultsDescription" : "Similar rates of AKI; cefepime causes more CNS toxicity",
"diseases" : "Infection",
"statusUsableDate" : "2024-02-22",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2810592",
"pageName" : "ACORN",
"expansion" : "Antibiotic Choice on Renal Outcomes",
"published" : "2023-10-14",
"pmid" : "37837651",
"pdfurl" : null,
"citation" : "Qian E, et al. \"Cefepime vs. piperacillin-tazobactam in adults hospitalized with acute infection\". JAMA. 2023. 330(16):1557-1567.",
"title" : "Cefepime vs. piperacillin-tazobactam in adults hospitalized with acute infection"
},
{
"pmid" : "21304082",
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/645514/joc15004_569_575.pdf",
"title" : "Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial",
"citation" : "Giuliano AE, et al. \"Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial\". The Journal of the American Medical Association. 2011. 305(6):569-575.",
"pageName" : "ACOSOG Z0011",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/645514",
"published" : "2011-02-09",
"expansion" : "The American College of Surgeons Oncology Group (ACOSOG) Z0011",
"briefResultsDescription" : "ALND no better than monitoring in SLNB-positive disease",
"diseases" : "Breast Cancer",
"statusUsableDate" : "2018-09-06",
"pageid" : 3545,
"timestamp" : "2018-09-06T17:17:42Z",
"subspecialties" : "Oncology;Surgery",
"briefDesignDescription" : "ALND in SLND-positive breast cancer",
"abbreviation" : "ACOSOG Z0011",
"trainingLevel" : "Fellow"
},
{
"published" : "2011-06-28",
"expansion" : "Acetylcysteine for Contrast-Induced Nephropathy Trial",
"fulltexturl" : "http://circ.ahajournals.org/cgi/pmidlookup?view",
"pageName" : "ACT",
"citation" : "ACT Investigators. \"Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography\". Circulation. 2011. 124:1250-1259.",
"title" : "Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography",
"pdfurl" : "http://circ.ahajournals.org/content/124/11/1250.full.pdf",
"pmid" : "21859972",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Acetylcysteine with IV contrast",
"abbreviation" : "ACT",
"subspecialties" : "Nephrology;Cardiology",
"timestamp" : "2017-12-03T22:33:07Z",
"pageid" : 2425,
"statusUsableDate" : "2015-08-01",
"diseases" : "Acute Kidney Injury;Acute Coronary Syndrome",
"briefResultsDescription" : "Acetylcysteine doesn't prevent contrast-induced acute kidney injury"
},
{
"statusUsableDate" : "2023-02-01",
"diseases" : "Carotid Stenosis",
"briefResultsDescription" : "Carotid stenting noninferior to endarterectomy in asymptomatic carotid stenosis",
"briefDesignDescription" : "Carotid stenting vs. endarterectomy",
"abbreviation" : "ACT I",
"trainingLevel" : "Resident",
"timestamp" : "2023-02-03T04:55:43Z",
"pageid" : 2721,
"subspecialties" : "Cardiology",
"title" : "Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis",
"citation" : "Rosenfield K, et al. \"Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis\". The New England Journal of Medicine. 2016. 374(11):1011-20.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1515706",
"pmid" : "26886419",
"published" : "2016-02-17",
"expansion" : "Stent versus endarterectomy for asymptomatic carotid stenosis",
"pageName" : "ACT I",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1515706"
},
{
"pageName" : "ACTIVE A",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0901301",
"expansion" : "Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events",
"published" : "2009-05-14",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0901301",
"pmid" : "19336502",
"title" : "Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation",
"citation" : "Connolly SJ, et al. \"Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2009. 360(20):2066-78.",
"timestamp" : "2017-12-03T22:33:09Z",
"pageid" : 360,
"subspecialties" : "Cardiology;Neurology",
"briefDesignDescription" : "ASA/clopidogrel vs. ASA in AF",
"abbreviation" : "ACTIVE A",
"trainingLevel" : "Resident",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "ASA/clopidogrel ↓ composite of stroke, non-CNS embolism, MI, or CV death and ↑ bleeding",
"statusUsableDate" : "2012-04-01"
},
{
"citation" : "Connolly SJ, et al. \"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.\". The Lancet. 2006. 367(9526):1903-12.",
"title" : "Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.",
"pmid" : "16765759",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606688454.pdf",
"expansion" : "Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events",
"published" : "2006-06-10",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)68845-4",
"pageName" : "ACTIVE W",
"statusUsableDate" : "2013-05-01",
"briefResultsDescription" : "Warfarin is superior to ASA/clopidogrel for stroke prevention in AF",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"trainingLevel" : "Intern",
"briefDesignDescription" : "ASA/clopidogrel vs. warfarin in AF",
"abbreviation" : "ACTIVE W",
"subspecialties" : "Cardiology;Neurology",
"pageid" : 1438,
"timestamp" : "2017-12-03T22:33:10Z"
},
{
"statusUsableDate" : "2020-06-30",
"diseases" : "Covid-19",
"briefResultsDescription" : "Remdesivir modestly shortens time to recovery mostly in severe disease",
"trainingLevel" : "Student",
"abbreviation" : "ACTT-1",
"briefDesignDescription" : "Remdesivir vs. placebo in Covid-19",
"subspecialties" : "Infectious Disease",
"timestamp" : "2020-07-02T17:55:05Z",
"pageid" : 4238,
"citation" : "Beigel JH, et al. \"Remdesivir for the Treatment of Covid-19 - Preliminary Report\". The New England Journal of Medicine. 2020. 1-12.",
"title" : "Remdesivir for the Treatment of Covid-19 - Preliminary Report",
"pdfurl" : "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262788/pdf/NEJMoa2007764.pdf",
"pmid" : "32445440",
"expansion" : "Adaptive Covid-19 Treatment Trial",
"published" : "2020-05-22",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2007764",
"pageName" : "ACTT-1"
},
{
"pmid" : "20843245",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005372",
"title" : "Neuromuscular blockers in early acute respiratory distress syndrome",
"citation" : "Papazian L, et al. \"Neuromuscular blockers in early acute respiratory distress syndrome\". The New England Journal of Medicine. 2010. 363(12):1107-1116.",
"pageName" : "ACURASYS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005372",
"expansion" : "ARDS et Curarisation Systematique",
"published" : "2010-09-16",
"briefResultsDescription" : "Cisatracurium improves 90-day survival and increases ventilator-free days",
"diseases" : "Acute Respiratory Distress Syndrome",
"statusUsableDate" : "2013-06-01",
"pageid" : 1119,
"timestamp" : "2019-06-05T22:43:36Z",
"subspecialties" : "Critical Care",
"briefDesignDescription" : "Cisatracurium in ARDS",
"abbreviation" : "ACURASYS",
"trainingLevel" : "resident"
},
{
"pmid" : "24643601",
"pdfurl" : "http://bit.ly/1HTY4kQ",
"title" : "Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study",
"citation" : "Righini M, et al. \"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study\". JAMA. 2014. 311(11):1117-1124.",
"pageName" : "ADJUST-PE",
"fulltexturl" : "http://bit.ly/1QgJ5k1",
"published" : "2014-03-19",
"expansion" : "Age aDJUSTed D-Dimer to rule out PE",
"briefResultsDescription" : "Age-adjusted D-dimer (age × 10 in patients >50) rules out PE",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"statusUsableDate" : "2015-05-01",
"pageid" : 2367,
"timestamp" : "2021-12-19T22:24:03Z",
"subspecialties" : "Hematology;Emergency Medicine",
"abbreviation" : "ADJUST-PE",
"briefDesignDescription" : "Age-adjusted D-dimer for PE",
"trainingLevel" : "Resident"
},
{
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "Hydrocortisone provides no benefit in 90-day mortality",
"statusUsableDate" : "2018-02-08",
"timestamp" : "2018-02-08T17:58:17Z",
"pageid" : 3528,
"subspecialties" : "Critical Care",
"abbreviation" : "ADRENAL",
"briefDesignDescription" : "Hydrocortisone in septic shock",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1705835",
"pmid" : "29347874",
"title" : "Adjunctive glucocorticoid therapy in patients with septic shock",
"citation" : "Venkatesh B, et al. \"Adjunctive glucocorticoid therapy in patients with septic shock\". New England Journal of Medicine. 2018. Epub 2018-01-19:1-12.",
"pageName" : "ADRENAL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1705835",
"published" : "2018-01-19",
"expansion" : "Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802987",
"pageName" : "ADVANCE",
"published" : "2008-06-06",
"expansion" : "Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802987",
"pmid" : "18539916",
"citation" : "Patel A, et al. \"Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes\". The New England Journal of Medicine. 2008. 358(24):2560-2572.",
"title" : "Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes",
"subspecialties" : "Endocrinology",
"timestamp" : "2014-09-19T13:02:39Z",
"pageid" : 248,
"trainingLevel" : "Intern",
"abbreviation" : "ADVANCE",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Intensive therapy reduces microvascular complications",
"statusUsableDate" : "2012-03-01"
},
{
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2203094",
"pmid" : "36027559",
"citation" : "Mullens W, et al. \"Acetazolamide in Acute Decompensated Heart Failure with Volume Overload\". NEJM. 2022. Epub 2022-08-27:1-11.",
"title" : "Acetazolamide in Acute Decompensated Heart Failure with Volume Overload",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2203094",
"pageName" : "ADVOR",
"expansion" : "Acetazolamide in Decompensated Heart Failure With Volume OveRload",
"published" : "2022-08-27",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Acetazolamide improves diuresis in acute HF",
"statusUsableDate" : "2022-09-15",
"subspecialties" : "Cardiology;Emergency Medicine;Critical Care",
"timestamp" : "2022-12-20T15:19:03Z",
"pageid" : 4655,
"trainingLevel" : "Student",
"briefDesignDescription" : "Acetazolamide vs. placebo in acute HF",
"abbreviation" : "ADVOR"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0708789",
"pageName" : "AF-CHF",
"expansion" : "Atrial Fibrillation and Congestive Heart Failure",
"published" : "2008-06-19",
"pmid" : "18565859",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0708789",
"citation" : "Roy D, et al. \"Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure\". The New England Journal of Medicine. 2008. 358(25):2667-2677.",
"title" : "Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure",
"subspecialties" : "Cardiology",
"pageid" : 2800,
"timestamp" : "2018-12-21T13:20:11Z",
"trainingLevel" : "Resident",
"abbreviation" : "AF-CHF",
"briefDesignDescription" : "Rhythm control for AF in HFrEF",
"briefResultsDescription" : "Rhythm control does not reduce CV mortality in AF with HF",
"diseases" : "Heart Failure",
"statusUsableDate" : "2018-12-07"
},
{
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No mortality difference, trend towards harm with rhythm control",
"diseases" : "Atrial Fibrillation",
"trainingLevel" : "Student",
"abbreviation" : "AFFIRM",
"briefDesignDescription" : "Rate vs. rhythm control in AF",
"subspecialties" : "Cardiology",
"pageid" : 87,
"timestamp" : "2025-05-15T20:16:04Z",
"citation" : "Wyse DG, et al. \"A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2002. 347(23):1825-1833.",
"title" : "A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation",
"pmid" : "12466506",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021328",
"published" : "2002-11-05",
"expansion" : "Atrial Fibrillation Follow-up Investigation of Rhythm Management",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021328",
"pageName" : "AFFIRM"
},
{
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Mammograms don't reduce breast cancer mortality in age 40-49 year old women",
"diseases" : "Breast Cancer",
"trainingLevel" : "Student",
"abbreviation" : "Age Trial",
"briefDesignDescription" : "Mammograms for 40-49 year old women",
"subspecialties" : "Oncology;Preventive Medicine",
"pageid" : 2307,
"timestamp" : "2017-12-03T22:33:43Z",
"citation" : "Moss SM, et al. \"Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial\". The Lancet. 2006. 368(9552):2053-2060.",
"title" : "Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial",
"pmid" : "17161727",
"pdfurl" : "",
"published" : "2006-12-09",
"expansion" : "",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)69834-6",
"pageName" : "Age Trial"
},
{
"expansion" : "Agents Intervening against Delirium in the Intensive Care Unit",
"published" : "2022-10-26",
"pageName" : "AID-ICU",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2211868",
"title" : "Haloperidol for the Treatment of Delirium in ICU Patients",
"citation" : "Andersen-Ranberg NC, et al. \"Haloperidol for the Treatment of Delirium in ICU Patients\". The New England Journal of Medicine. 2022. Online ahead of print(2022-10-26):1-11.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2211868",
"pmid" : "36286254",
"abbreviation" : "AID-ICU",
"briefDesignDescription" : "Haloperidol for ICU delirium",
"trainingLevel" : "resident",
"timestamp" : "2023-01-15T01:17:39Z",
"pageid" : 5131,
"subspecialties" : "Critical Care",
"statusUsableDate" : "2022-11-02",
"diseases" : "Delirium",
"briefResultsDescription" : "Haloperidol does not improve days alive out of hospital"
},
{
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:33:14Z",
"pageid" : 2940,
"trainingLevel" : "Resident",
"abbreviation" : "AIDA",
"briefDesignDescription" : "Scaffold vs. stent in PCI",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Scaffold inferior to stent in PCI",
"statusUsableDate" : "2017-06-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1614954",
"pageName" : "AIDA",
"published" : "2017-06-14",
"expansion" : "Amsterdam Investigator-Initiated Absorb Strategy All-Comers Trial",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1614954",
"pmid" : "28402237",
"citation" : "Wykrzykowska JJ et al. \"Bioresorbable scaffolds versus metallic stents in routine PCI\". The New England Journal of Medicine. 2017. 376(24):2319-2328.",
"title" : "Bioresorbable scaffolds versus metallic stents in routine PCI"
},
{
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/2679131/jama_huttner_2018_oi_180034.pdf",
"pmid" : "29710295",
"title" : "Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial",
"citation" : "Huttner A, et al. \"Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial\". JAMA. 2018. 319(17):1781-1789.",
"pageName" : "AIDA-WP2",
"fulltexturl" : "https://jamanetwork.com/journals/jama/article-abstract/2679131",
"published" : "2018-03-01",
"expansion" : "",
"diseases" : "Urinary Tract Infection",
"briefResultsDescription" : "Nitrofurantoin improved outcomes uncomplicated UTI",
"statusUsableDate" : "2024-10-24",
"timestamp" : "2024-10-17T19:52:36Z",
"pageid" : 3640,
"subspecialties" : "Infectious Disease;Emergency Medicine",
"briefDesignDescription" : "Nitrofurantoin vs. fosfomycin in UTI",
"abbreviation" : "AIDA-WP2",
"trainingLevel" : "Medical Student"
},
{
"expansion" : "AnakInRa for Treatment of Recurrent Idiopathic Pericarditis",
"published" : "2016-11-08",
"pageName" : "AIRTRIP",
"fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2579869",
"title" : "Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence",
"citation" : "Brucato A, et al. \"Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence\". Journal of the American Medical Association. 2016. 316(18):1906-1912.",
"pmid" : "27825009",
"pdfurl" : null,
"abbreviation" : "AIRTRIP",
"briefDesignDescription" : "Anakinra in colchicine-resistant pericarditis",
"trainingLevel" : "Resident",
"pageid" : 2865,
"timestamp" : "2018-10-16T05:18:00Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "Anakinra superior to placebo in colchicine resistant, steroid-dependent pericarditis",
"diseases" : "Pericarditis"
},
{
"diseases" : "Acute Kidney Injury",
"briefResultsDescription" : "No mortality difference between early or delayed RRT in ICU patients with AKI",
"statusUsableDate" : "2017-08-01",
"subspecialties" : "Critical Care;Nephrology",
"timestamp" : "2019-03-27T18:29:53Z",
"pageid" : 2937,
"trainingLevel" : "Resident",
"abbreviation" : "AKIKI",
"briefDesignDescription" : "Early vs. late RRT in severe AKI in ICU",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603017",
"pmid" : "27181456",
"citation" : "Gaudry S, et al. \"Initiation strategies for renal-replacement therapy in the intensive care unit\". The New England Journal of Medicine. 2016. 375(2):122-133.",
"title" : "Initiation strategies for renal-replacement therapy in the intensive care unit",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603017",
"pageName" : "AKIKI",
"published" : "2016-07-14",
"expansion" : "Artificial Kidney Initiation in Kidney Injury"
},
{
"subspecialties" : "Critical Care",
"timestamp" : "2018-07-03T03:04:07Z",
"pageid" : 1781,
"trainingLevel" : "resident",
"briefDesignDescription" : "Daily albumin in severe sepsis",
"abbreviation" : "ALBIOS",
"diseases" : "Sepsis",
"briefResultsDescription" : "Daily albumin with no mortality benefit at 28 days",
"statusUsableDate" : "2014-03-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305727",
"pageName" : "ALBIOS",
"expansion" : "Albumin Italian Outcome Sepsis",
"published" : "2014-03-18",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1305727",
"pmid" : "24635772",
"citation" : "Caironi P, et al. \"Albumin replacement in patients with severe sepsis or septic shock\". The New England Journal of Medicine. 2014. 370(15):1412-1421.",
"title" : "Albumin replacement in patients with severe sepsis or septic shock"
},
{
"trainingLevel" : "Intern",
"abbreviation" : "",
"briefDesignDescription" : "Albumin for SBP in cirrhosis",
"subspecialties" : "Gastroenterology;Infectious Disease",
"pageid" : 2501,
"timestamp" : "2017-12-03T22:33:45Z",
"statusUsableDate" : "2017-09-01",
"briefResultsDescription" : "Albumin reduces AKI and mortality in SBP in cirrhosis",
"diseases" : "Spontaneous Bacterial Peritonitis;Cirrhosis",
"published" : "1999-08-05",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199908053410603",
"pageName" : "Albumin for SBP",
"citation" : "Sort P, et al. \"Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis\". The New England Journal of Medicine. 1999. 341(6):403-409.",
"title" : "Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis",
"pmid" : "10432325",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199908053410603"
},
{
"abbreviation" : "ALLHAT",
"briefDesignDescription" : "Chlorthalidone in HTN",
"trainingLevel" : "Student",
"timestamp" : "2018-09-14T00:37:12Z",
"pageid" : 171,
"subspecialties" : "Nephrology;Cardiology",
"statusUsableDate" : "2012-03-01",
"diseases" : "Hypertension",
"briefResultsDescription" : "Chlorthalidone performs similarly to lisinopril and amlodipine",
"published" : "2002-12-18",
"expansion" : "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial",
"pageName" : "ALLHAT",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/vol/288/pg/2981",
"title" : "Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs. Diuretic",
"citation" : "Wright JT, et al. \"Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs. Diuretic\". Journal of the American Medical Association. 2002. 288(23):2981-2997.",
"pdfurl" : null,
"pmid" : "12479763"
},
{
"statusUsableDate" : "2020-11-20",
"briefResultsDescription" : "Pravastatin does not decrease mortality",
"diseases" : "Coronary Artery Disease",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Pravastatin vs usual care for ASCVD primary prevention",
"abbreviation" : "ALLHAT-LLT",
"subspecialties" : "Cardiology",
"pageid" : 2949,
"timestamp" : "2020-11-11T16:18:38Z",
"citation" : "Han BH, et al. \"Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial\". JAMA Internal Medicine. 2017. 177(7):955-965.",
"title" : "Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial",
"pmid" : "28531241",
"pdfurl" : "http://www.natap.org/2017/HIV/jamainternal_Han_2017_oi_170031.pdf",
"published" : "2017-07-01",
"expansion" : "",
"fulltexturl" : "http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2628971",
"pageName" : "ALLHAT-LLT Elderly"
},
{
"pmid" : "19369404",
"pdfurl" : "http://jasn.asnjournals.org/content/20/5/1103.full.pdf",
"citation" : "Appel GB, et al. \"Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.\". Journal of American Society of Nephrology. 2009. 20(5):1103–1112.",
"title" : "Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.",
"fulltexturl" : "http://jasn.asnjournals.org/content/20/5/1103.long",
"pageName" : "ALMS",
"published" : "2009-05-01",
"expansion" : "Aspreva Lupus Management Study",
"briefResultsDescription" : "MMF similar to cyclophosphamide in lupus nephritis",
"diseases" : "Lupus Nephritis;Lupus",
"statusUsableDate" : "2017-11-01",
"subspecialties" : "Nephrology;Rheumatology",
"pageid" : 2655,
"timestamp" : "2018-02-04T17:46:37Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "MMF vs. CTX in lupus nephritis",
"abbreviation" : "ALMS"
},
{
"briefDesignDescription" : "Azithromycin in chronic asthma",
"abbreviation" : "AMAZES",
"trainingLevel" : "Resident",
"pageid" : 3615,
"timestamp" : "2020-07-02T15:32:34Z",
"subspecialties" : "Pulmonology",
"statusUsableDate" : "2020-06-29",
"briefResultsDescription" : "Athithromycin reduced rate of exacerbations and improved QOL",
"diseases" : "Asthma",
"published" : "2017-08-12",
"expansion" : "Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma",
"pageName" : "AMAZES",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(17)31281-3",
"title" : "Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): A randomised, double-blind, placebo-controlled trial",
"citation" : "Gibson PG, et al. \"Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): A randomised, double-blind, placebo-controlled trial\". Lancet. 2017. 390(10095):659-668.",
"pmid" : "28687413",
"pdfurl" : ""
},
{
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1413687",
"pageName" : "AMBITION",
"published" : "2015-08-27",
"expansion" : "Ambrisentan and Tadalafil in Patients with Pulmonary Arterial Hypertension",
"pmid" : "26308684",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1413687",
"citation" : "Galiè N, et al. \"Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension\". The New England Journal of Medicine. 2015. 373(9):834-44.",
"title" : "Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension",
"subspecialties" : "Pulmonology",
"pageid" : 4410,
"timestamp" : "2025-06-19T18:32:30Z",
"trainingLevel" : "Resident",
"abbreviation" : "AMBITION",
"briefDesignDescription" : "Combination of ambrisentan & tadalafil vs monotherapy in PAH",
"briefResultsDescription" : "Ambrisentan & tadalafil combination therapy resulted in fewer clinical failures than monotherapy",
"diseases" : "Pulmonary Hypertension",
"statusUsableDate" : "2025-02-26"
},
{
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"briefResultsDescription" : "Apixaban noninferior to warfarin for VTE recurrence; less bleeding",
"statusUsableDate" : "2013-08-01",
"timestamp" : "2023-06-22T19:17:55Z",
"pageid" : 1609,
"subspecialties" : "Hematology;Pulmonology",
"briefDesignDescription" : "Apixaban vs. warfarin in VTE",
"abbreviation" : "AMPLIFY",
"trainingLevel" : "Intern",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302507",
"pmid" : "23808982",
"title" : "Oral apixaban for the treatment of acute venous thromboembolism",
"citation" : "Agnelli G, et al. \"Oral apixaban for the treatment of acute venous thromboembolism\". The New England Journal of Medicine. 2013. 369(9):799-808.",
"pageName" : "AMPLIFY",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1302507",
"expansion" : "Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy",
"published" : "2013-07-01"
},
{
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"briefResultsDescription" : "Apixaban reduces recurrent VTE",
"statusUsableDate" : "2013-05-01",
"timestamp" : "2025-09-11T17:54:18Z",
"pageid" : 1245,
"subspecialties" : "Hematology",
"abbreviation" : "AMPLIFY-EXT",
"briefDesignDescription" : "Prolonged apixaban after VTE",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1207541",
"pmid" : "23216615",
"title" : "Apixaban for extended treatment of venous thromboembolism",
"citation" : "Agnelli G, et al. \"Apixaban for extended treatment of venous thromboembolism\". The New England Journal of Medicine. 2013. 368(8):699-708.",
"pageName" : "AMPLIFY-EXT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1207541",
"expansion" : "Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy-Extended Treatment",
"published" : "2013-02-21"
},
{
"fulltexturl" : "http://jama.jamanetwork.com/article.aspx?articleid",
"pageName" : "Annane Trial",
"published" : "2002-08-21",
"expansion" : "",
"pmid" : "12186604",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4844/JCE10061.pdf",
"citation" : "Annane D, et al. \"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock\". Journal of the American Medical Association. 2002. 288(7):862-871.",
"title" : "Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock",
"subspecialties" : "Critical Care",
"pageid" : 939,
"timestamp" : "2020-03-17T17:50:15Z",
"trainingLevel" : "Resident",
"abbreviation" : "Ger-Inf-05",
"briefDesignDescription" : "Corticosteroids in septic shock",
"briefResultsDescription" : "Corticosteroids reduce mortality in septic shock with adrenal insufficiency",
"diseases" : "Sepsis;Shock",
"statusUsableDate" : "2013-02-01"
},
{
"abbreviation" : "ANNEXA",
"briefDesignDescription" : "Andexanet for reversing Xa inhibitors",
"trainingLevel" : "Resident",
"pageid" : 2502,
"timestamp" : "2018-07-11T03:22:16Z",
"subspecialties" : "Hematology",
"statusUsableDate" : "2017-03-01",
"briefResultsDescription" : "Andexanet reverses Xa inhibitors",
"diseases" : "Hemorrhage",
"published" : "2015-12-17",
"expansion" : "Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors",
"pageName" : "ANNEXA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1510991",
"title" : "Andexanet alfa for the reversal of factor Xa inhibitor activity",
"citation" : "Siegal DM, et al. \"Andexanet alfa for the reversal of factor Xa inhibitor activity\". The New England Journal of Medicine. 2015. 373(25):2413-2424.",
"pmid" : "26559317",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510991"
},
{
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1607887",
"pageName" : "ANNEXA-4",
"published" : "2016-09-22",
"expansion" : "Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of Factor Xa Inhibitors",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1607887",
"pmid" : "27573206",
"citation" : "Connolly SJ, et al. \"Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors\". The New England Journal of Medicine. 2016. 375(12):1131-1141.",
"title" : "Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors",
"subspecialties" : "Hematology;Emergency Medicine;Cardiology",
"timestamp" : "2019-03-07T17:07:14Z",
"pageid" : 3641,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Andexanet alfa for factor Xa inhibitor reversal",
"abbreviation" : "ANNEXA-4",
"diseases" : "Hemorrhage",
"briefResultsDescription" : "Andexanet alfa achieved hemostasis in 80%",
"statusUsableDate" : "2019-02-07"
},
{
"diseases" : "HIV",
"briefResultsDescription" : "Pre-exposure prophylaxis reduces HIV transmission in high-risk men",
"statusUsableDate" : "2015-12-01",
"subspecialties" : "Infectious Disease",
"timestamp" : "2017-12-03T22:33:27Z",
"pageid" : 2649,
"trainingLevel" : "Student",
"abbreviation" : "ANRS IPERGAY",
"briefDesignDescription" : "Pre-exposure prophylaxis in high-risk men",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506273",
"pmid" : "26624850",
"citation" : "Molina JM, et al. \"On-demand preexposure prophylaxis in men at high risk for HIV-1 infection\". The New England Journal of Medicine. 2015. 373(23):2237-2246.",
"title" : "On-demand preexposure prophylaxis in men at high risk for HIV-1 infection",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506273",
"pageName" : "ANRS IPERGAY",
"published" : "2015-12-03",
"expansion" : ""
},
{
"published" : "2006-10-01",
"expansion" : "",
"fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/fulltext",
"pageName" : "Antibiotics in Cirrhosis with Hemorrhage",
"citation" : "Fernández J, et al. \"Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage\". Gastroenterology. 2006. 131(4):1049-56.",
"title" : "Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage",
"pdfurl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/pdf",
"pmid" : "17030175",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Ceftriaxone vs. norfloxacin in cirrhotics with GI bleed",
"abbreviation" : "",
"subspecialties" : "Gastroenterology;Infectious Disease",
"timestamp" : "2016-04-01T23:26:41Z",
"pageid" : 82,
"statusUsableDate" : "2012-03-01",
"diseases" : "Cirrhosis;Gastrointestinal Hemorrhage",
"briefResultsDescription" : "Ceftriaxone reduces the incidence of bacterial infection"
},
{
"statusUsableDate" : "2021-09-30",
"diseases" : "Depression",
"briefResultsDescription" : "Maintenance of antidepressants associated with less depression relapse",
"trainingLevel" : "student",
"abbreviation" : "ANTLER",
"briefDesignDescription" : "Maintenance vs. discontinuation of antidepressants",
"subspecialties" : "Psychiatry",
"timestamp" : "2021-10-08T13:12:27Z",
"pageid" : 4441,
"citation" : "Lewis G, et al. \"Maintenance or discontinuation of antidepressants in primary care\". The New England Journal of Medicine. 2021. 385(14):1257-1267.",
"title" : "Maintenance or discontinuation of antidepressants in primary care",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2106356",
"pmid" : "34587384",
"published" : "2021-09-30",
"expansion" : "Antidepressants to Prevent Relapse in Depression",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2106356",
"pageName" : "ANTLER"
},
{
"pageName" : "APEX",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1601747",
"published" : "2017-08-27",
"expansion" : "Acutely Medically Ill VTE Prevention with Extended Duration Betrixaban",
"pmid" : "27232649",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1601747",
"title" : "Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients",
"citation" : "Cohen AT, et al. \"Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients\". The New England Journal of Medicine. 2016. 375(6):534-44.",
"pageid" : 3713,
"timestamp" : "2018-11-15T17:21:28Z",
"subspecialties" : "Hematology",
"briefDesignDescription" : "Betrixaban for extended VTE prophylaxis",
"abbreviation" : "APEX",
"trainingLevel" : "resident",
"briefResultsDescription" : "Betrixaban did not meet its primary endpoint",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"statusUsableDate" : "2018-11-15"
},
{
"abbreviation" : "AAPAC",
"briefDesignDescription" : "Antibiotics vs. surgery for acute appendicitis",
"trainingLevel" : "Resident",
"pageid" : 3539,
"timestamp" : "2019-01-03T23:02:05Z",
"subspecialties" : "Surgery;Infectious Disease",
"statusUsableDate" : "2018-07-26",
"briefResultsDescription" : "Antibiotics not non-inferior to surgeyr",
"diseases" : "Appendicitis",
"published" : "2015-06-16",
"expansion" : "Appendicitis Acuta",
"pageName" : "APPAC",
"fulltexturl" : "https://jamanetwork.com/journals/jama/article-abstract/2703354",
"title" : "Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial",
"citation" : "Salminen P, et al. \"Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial\". JAMA. 2018. 320(12):1259-1265.",
"pmid" : "26080338",
"pdfurl" : null
},
{
"expansion" : "Recombinant Human Activated Protein C and Low Dose of Hydrocortisone and Fludrocortisone in Adult Septic Shock",
"published" : "2018-03-01",
"pageName" : "APROCCHSS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1705716",
"title" : "Hydrocortisone plus Fludrocortisone for Adults with Septic Shock",
"citation" : "Annane D, et al. \"Hydrocortisone plus Fludrocortisone for Adults with Septic Shock\". The New England Journal of Medicine. 2018. 378(9):809-818.",
"pmid" : "29490185",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1705716",
"briefDesignDescription" : "Steroids in septic shock",
"abbreviation" : "APROCCHSS",
"trainingLevel" : "Resident",
"pageid" : 3551,
"timestamp" : "2021-04-08T18:21:59Z",
"subspecialties" : "Critical Care",
"statusUsableDate" : "2021-03-30",
"briefResultsDescription" : "Hydrocortisone plus fludrocortisone improved survival in septic shock",
"diseases" : "Sepsis"
},
{
"timestamp" : "2021-02-23T14:31:34Z",
"pageid" : 114,
"subspecialties" : "Critical Care",
"briefDesignDescription" : "Low vs. traditional volumes in ARDS",
"abbreviation" : "ARDSNet",
"trainingLevel" : "Intern",
"diseases" : "Acute Respiratory Distress Syndrome",
"briefResultsDescription" : "Mortality benefit and more ventilator-free days with lung-protective strategy",
"statusUsableDate" : "2012-03-01",
"pageName" : "ARDSNet",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200005043421801",
"expansion" : "Acute Respiratory Distress Syndrome Network",
"published" : "2000-05-04",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200005043421801",
"pmid" : "10793162",
"title" : "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome",
"citation" : "Brower RG, et al. \"Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome\". The New England Journal of Medicine. 2000. 342(18):1301-1308."
},
{
"citation" : "Bash LD, et al. \"Poor Glycemic Control in Diabetes and the Risk of Incident Chronic Kidney Disease Even in the Absence of Albuminuria and Retinopathy\". Archives of Internal Medicine. 2008. 168(22):2440-2447.",
"title" : "Poor Glycemic Control in Diabetes and the Risk of Incident Chronic Kidney Disease Even in the Absence of Albuminuria and Retinopathy",
"pmid" : "19064828",
"pdfurl" : "http://archinte.jamanetwork.com/article.aspx?articleid",
"expansion" : "Atherosclerosis Risk in Communities",
"published" : "2008-12-08",
"fulltexturl" : "http://archinte.jamanetwork.com/article.aspx?articleid",
"pageName" : "ARIC A1c and CKD",
"statusUsableDate" : "2025-06-05",
"briefResultsDescription" : "Elevated HbA1c increases risk of CKD",
"diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
"trainingLevel" : "Fellow",
"abbreviation" : "ARIC",
"briefDesignDescription" : "HbA1c and CKD risk in DM",
"subspecialties" : "Endocrinology",
"pageid" : 2701,
"timestamp" : "2025-06-05T17:23:41Z"
},
{
"citation" : "ARISE and ANZICS writers. \"Goal-directed resuscitation for patients with early septic shock\". The New England Journal of Medicine. 2014. 371(16):1496-1506.",
"title" : "Goal-directed resuscitation for patients with early septic shock",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1404380",
"pmid" : "25272316",
"expansion" : "Australasian Resuscitation in Sepsis Evaluation",
"published" : "2014-10-16",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1404380",
"pageName" : "ARISE",
"statusUsableDate" : "2014-11-01",
"diseases" : "Sepsis",
"briefResultsDescription" : "EGDT doesn't reduce mortality in sepsis",
"trainingLevel" : "Intern",
"abbreviation" : "ARISE",
"briefDesignDescription" : "EGDT vs. usual care in sepsis",
"subspecialties" : "Critical Care",
"timestamp" : "2017-12-03T22:33:28Z",
"pageid" : 2216
},
{
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Apixaban better for CVA prevention in AF",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"trainingLevel" : "Intern",
"abbreviation" : "ARISTOTLE",
"briefDesignDescription" : "Apixaban vs. warfarin in AF",
"subspecialties" : "Cardiology;Neurology",
"pageid" : 1497,
"timestamp" : "2018-03-29T18:55:04Z",
"citation" : "Granger CB, et al. \"Apixaban versus warfarin in patients with atrial fibrillation\". The New England Journal of Medicine. 2011. 365(11):981-982.",
"title" : "Apixaban versus warfarin in patients with atrial fibrillation",
"pmid" : "21870978",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1107039",
"published" : "2011-09-15",
"expansion" : "Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1107039",
"pageName" : "ARISTOTLE"
},
{
"citation" : "Thwaites GE, et al. \"Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial\". The Lancet. 2017. 391(10121):668-678.",
"title" : "Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial",
"pmid" : "29249276",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(17)32456-X.pdf",
"expansion" : "Adjunctive rifampicin for Staphylococcus Aureus Bacteraemia",
"published" : "2017-12-14",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32456-X/fulltext",
"pageName" : "ARREST",
"statusUsableDate" : "2019-07-31",
"briefResultsDescription" : "Adjunctive rifampin does not reduce mortality in S. aureus bacteremia",
"diseases" : "Bacteremia",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Rifampin in S. aureus bacteremia",
"abbreviation" : "ARREST",
"subspecialties" : "Infectious Disease",
"pageid" : 3569,
"timestamp" : "2019-08-02T19:20:32Z"
},
{
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Single IMA grafting non-inferior to bilateral IMA grafting in multivessel CAD",
"statusUsableDate" : "2019-02-02",
"timestamp" : "2019-10-17T17:40:06Z",
"pageid" : 3756,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Bilateral vs. single IMA graft in multivessel CAD",
"abbreviation" : "ART",
"trainingLevel" : "Resident",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1610021",
"pmid" : "30699314",
"title" : "Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years",
"citation" : "Taggart DP, et al. \"Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years\". The New England Journal of Medicine. 2019. 380(5):437-446.",
"pageName" : "ART",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1610021",
"published" : "2019-01-31",
"expansion" : "Arterial Revascularization Trial"
},
{
"timestamp" : "2025-01-30T19:13:30Z",
"pageid" : 5604,
"subspecialties" : "Cardiology",
"abbreviation" : "ARTESIA",
"briefDesignDescription" : "Apixaban vs. aspirin in subclinical AF",
"trainingLevel" : "Resident",
"diseases" : "Atrial Fibrillation",
"briefResultsDescription" : "Apixaban reduced stroke, but increased major bleeding",
"statusUsableDate" : "2025-01-30",
"pageName" : "ARTESIA",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2310234",
"expansion" : "Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation",
"published" : "2023-11-12",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2310234",
"pmid" : "37952132",
"title" : "Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation",
"citation" : "Healey JS, et al. \"Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation\". The New England Journal of Medicine. 2023. 390(2):107-117."
},
{
"diseases" : "Diabetes",
"briefResultsDescription" : "Aspirin reduces cardiovascular events but increases bleeding vs. placebo",
"statusUsableDate" : "2018-09-06",
"subspecialties" : "Cardiology",
"timestamp" : "2019-09-03T18:02:52Z",
"pageid" : 3698,
"trainingLevel" : "Resident",
"abbreviation" : "ASCEND",
"briefDesignDescription" : "Aspirin for vascular disease prevention in DM",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1804988",
"pmid" : "30146931",
"citation" : "Bowman L, et al. \"Effects of aspirin for primary prevention in persons with diabetes mellitus\". The New England Journal of Medicine. 2018. epub 2018-08-26:1-11.",
"title" : "Effects of aspirin for primary prevention in persons with diabetes mellitus",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1804988",
"pageName" : "ASCEND (Aspirin)",
"published" : "2018-08-26",
"expansion" : "A Study of Cardiovascular Events in Diabetes"
},
{
"statusUsableDate" : "2014-07-01",
"diseases" : "Pulmonary Fibrosis",
"briefResultsDescription" : "Pirfenidone reduces progression of IPF",
"abbreviation" : "ASCEND",
"briefDesignDescription" : "Pirfenidone in IPF",
"trainingLevel" : "Fellow",
"timestamp" : "2018-09-13T17:56:54Z",
"pageid" : 1825,
"subspecialties" : "Pulmonology",
"title" : "A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis",
"citation" : "King TE, et al. \"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis\". The New England Journal of Medicine. 2014. 370(22):2083-2092.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402582",
"pmid" : "24836312",
"expansion" : "Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis",
"published" : "2014-05-29",
"pageName" : "ASCEND (IPF)",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402582"
},
{
"abbreviation" : "ASPEN",
"briefDesignDescription" : "Zanubrutinib vs. ibrutinib in WM",
"trainingLevel" : "Fellow",
"timestamp" : "2025-06-19T18:36:44Z",
"pageid" : 4448,
"subspecialties" : "Hematology;Oncology",
"statusUsableDate" : "2021-11-30",
"diseases" : "Waldenström Macroglobulinemia;Lymphoma",
"briefResultsDescription" : "Similar efficacy, zanubrutinib perhaps less toxic",
"expansion" : "",
"published" : "2020-10-29",
"pageName" : "ASPEN",
"fulltexturl" : "https://ashpublications.org/blood/article/136/18/2038/461625/A-randomized-phase-3-trial-of-zanubrutinib-vs",
"title" : "ASPEN",
"citation" : "Tam C, et al. \"ASPEN\". Blood. 2020. 136(18):2038-2050.",
"pdfurl" : "https://ashpublications.org/blood/article-pdf/136/18/2038/1779238/bloodbld2020006844.pdf",
"pmid" : "32731259"
},
{
"expansion" : "Aspirin to Prevent Recurrent Venous Thromboembolism",
"published" : "2012-11-04",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210384",
"pageName" : "ASPIRE",
"citation" : "Brighton TA, et al. \"Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism\". The New England Journal of Medicine. 2012. 367(21):1979-1987.",
"title" : "Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism",
"pmid" : "23121403",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210384",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Aspirin after VTE treatment",
"abbreviation" : "ASPIRE",
"subspecialties" : "Hematology",
"pageid" : 1241,
"timestamp" : "2017-12-03T22:33:32Z",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "ASA probably reduces recurrent VTE",
"diseases" : "Venous Thromboembolism"
},
{
"statusUsableDate" : "2019-05-23",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Aspirin without 1° prevention benefit in adults >70 years",
"briefDesignDescription" : "Aspirin for ASCVD 1° prevention if age >70",
"abbreviation" : "ASPREE",
"trainingLevel" : "Student",
"timestamp" : "2025-05-22T17:33:23Z",
"pageid" : 3709,
"subspecialties" : "Preventive Medicine;Cardiology",
"title" : "Effect of aspirin on disability-free survival in the healthy elderly",
"citation" : "McNeil JJ, et al. \"Effect of aspirin on disability-free survival in the healthy elderly\". The New England Journal of Medicine. 2018. 379(16):1-10.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800722",
"pmid" : "30221596",
"expansion" : "Aspirin in Reducing Events in the Elderly",
"published" : "2018-09-16",
"pageName" : "ASPREE",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800722"
},
{
"published" : "2009-11-12",
"expansion" : "Angioplasty and Stenting for Renal Artery Lesions",
"pageName" : "ASTRAL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0905368",
"title" : "Revascularization versus medical therapy for renal-artery stenosis",
"citation" : "Wheatley K, et al. \"Revascularization versus medical therapy for renal-artery stenosis\". The New England Journal of Medicine. 2009. 361(20):1953-1962.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0905368",
"pmid" : "19907042",
"abbreviation" : "ASTRAL",
"briefDesignDescription" : "Revascularization in RAS",
"trainingLevel" : "Resident",
"timestamp" : "2018-01-04T18:44:16Z",
"pageid" : 1684,
"subspecialties" : "Nephrology",
"statusUsableDate" : "2013-09-01",
"diseases" : "Renal Artery Stenosis;Hypertension",
"briefResultsDescription" : "Revascularization no better than medical therapy alone in RAS"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Angiotensin II vs. placebo in vasodilatory shock",
"abbreviation" : "ATHOS-3",
"subspecialties" : "Critical Care",
"timestamp" : "2019-09-11T15:27:57Z",
"pageid" : 2950,
"statusUsableDate" : "2017-08-01",
"diseases" : "Shock",
"briefResultsDescription" : "Angiotensin II superior to placebo in vasodilatory shock",
"published" : "2017-08-03",
"expansion" : "Angiotensin II for the Treatment of High-Output Shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1704154",
"pageName" : "ATHOS-3",
"citation" : "Khanna A et al. \"Angiotensin II for the Treatment of Vasodilatory Shock\". New Engl J Med. 2017. 377:419-30.",
"title" : "Angiotensin II for the Treatment of Vasodilatory Shock",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1704154",
"pmid" : "28528561"
},
{
"subspecialties" : "Oncology",
"pageid" : 1581,
"timestamp" : "2017-12-03T22:33:36Z",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "10y vs. 5y tamoxifen in breast cancer",
"abbreviation" : "ATLAS",
"briefResultsDescription" : "10 years of tamoxifen reduces recurrence and mortality",
"diseases" : "Breast Cancer",
"statusUsableDate" : "2013-10-01",
"fulltexturl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596060/",
"pageName" : "ATLAS",
"expansion" : "Adjuvant Tamoxifen: Longer Against Shorter",
"published" : "2013-03-09",
"pmid" : "23219286",
"pdfurl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61963-1/fulltext",
"citation" : "Davies C, et al. \"Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial\". The Lancet. 2013. 381(9869):805-16.",
"title" : "Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial"
},
{
"citation" : "Mega JL, et al. \"Rivaroxaban in Patients with Recent Acute Coronary Syndrome\". The New England Journal of Medicine. 2012. 366(1):9-19.",
"title" : "Rivaroxaban in Patients with Recent Acute Coronary Syndrome",
"pmid" : "22077192",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112277",
"published" : "2012-01-05",
"expansion" : "Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112277",
"pageName" : "ATLAS ACS-2, TIMI 51",
"statusUsableDate" : "2013-03-01",
"briefResultsDescription" : "Rivaroxaban reduces cardiovascular death, MI, and stroke, but increases nonfatal bleeding",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Rivaroxaban after ACS",
"abbreviation" : "ATLAS ACS 2-TIMI 51",
"subspecialties" : "Cardiology",
"pageid" : 174,
"timestamp" : "2017-12-03T22:33:37Z"
},
{
"briefResultsDescription" : "Intensive RRT yields similar mortality as conventional RRT in critically ill patients with ATN",
"diseases" : "Acute Kidney Injury;Critical Illness",
"statusUsableDate" : "2015-03-01",
"subspecialties" : "Nephrology;Critical Care",
"pageid" : 2339,
"timestamp" : "2017-12-03T22:33:39Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "RRT intensity in ATN",
"abbreviation" : "ATN",
"pmid" : "18492867",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802639",
"citation" : "Palevsky PM, et al. \"Intensity of renal support in critically ill patients with acute kidney injury\". The New England Journal of Medicine. 2008. 359(1):7-20.",
"title" : "Intensity of renal support in critically ill patients with acute kidney injury",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802639",
"pageName" : "ATN",
"published" : "2008-07-03",
"expansion" : "Acute Renal Failure Trial Network Study"
},
{
"citation" : "Maurer MS, et al. \"Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy\". The New England Journal of Medicine. 2018. 379(11):1007-1016.",
"title" : "Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1805689",
"pmid" : "30145929",
"expansion" : "The Transthyretin Amyloidosis Cardiomyopathy Clinical Trial",
"published" : "2018-08-27",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1805689",
"pageName" : "ATTR-ACT",
"statusUsableDate" : "2018-09-05",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Tafamidis superior to placebo in amyloid cardiomyopathy",
"trainingLevel" : "Resident",
"abbreviation" : "ATTR-ACT",
"briefDesignDescription" : "Tafamidis vs. placebo in amyloid cardiomyopathy",
"subspecialties" : "Cardiology",
"timestamp" : "2019-05-21T14:25:21Z",
"pageid" : 3696
},
{
"abbreviation" : "ATTRACT",
"briefDesignDescription" : "Pharmacomechanical therapy vs. anticoagulation in DVT",
"trainingLevel" : "resident",
"timestamp" : "2019-07-17T05:12:53Z",
"pageid" : 3546,
"subspecialties" : "Hematology",
"statusUsableDate" : "2018-07-19",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Post-Thrombotic Syndrome",
"briefResultsDescription" : "No difference with intervention vs. anticoagulation",
"published" : "2017-12-07",
"expansion" : "Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis",
"pageName" : "ATTRACT",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1615066",
"title" : "Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis",
"citation" : "Vedantham S, et al. \"Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis\". The New England Journal of Medicine. 2017. 377(23):2240-2252.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1615066",
"pmid" : "29211671"
},
{
"citation" : "Lopes RD, et al. \"Antithrombotic therapy after acute coronary syndrome or PCI in atrial fibrillation\". The New England Journal of Medicine. 2019. 380(16):1509-1524.",
"title" : "Antithrombotic therapy after acute coronary syndrome or PCI in atrial fibrillation",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817083",
"pmid" : "30883055",
"published" : "2019-04-18",
"expansion" : "An Open-label, 2 x 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban vs. Vitamin K Antagonist and Aspirin vs. Aspirin Placebo in Patients with Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1817083",
"pageName" : "AUGUSTUS",
"statusUsableDate" : "2019-10-17",
"diseases" : "Coronary Artery Disease;Atrial Fibrillation",
"briefResultsDescription" : "Apixaban with lower bleeding",
"trainingLevel" : "Resident",
"abbreviation" : "AUGUSTUS",
"briefDesignDescription" : "DOAC, VKA, antiplatelets after PCI with stent and AF",
"subspecialties" : "Cardiology",
"timestamp" : "2025-05-22T17:32:42Z",
"pageid" : 3947
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"trainingLevel" : "Resident",
"briefDesignDescription" : "Rosuvastatin in ESRD",
"abbreviation" : "AURORA",
"subspecialties" : "Cardiology;Nephrology",
"timestamp" : "2018-12-20T20:31:01Z",
"pageid" : 2390,
"statusUsableDate" : "2018-12-20",
"diseases" : "Cardiovascular Disease;Myocardial Infarction;Stroke",
"briefResultsDescription" : "No difference in number of cardiovascular events",
"expansion" : "A Study to Evaluate the Use of Rosuvastatin in Subjects on Regular Hemodialysis: An Assessment of Survival and Cardiovascular Events",
"published" : "2009-04-02",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810177",
"pageName" : "AURORA",
"citation" : "Fellstrom BC, et al. \"Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis\". The New England Journal of Medicine. 2009. 360(14):1395-1407.",
"title" : "Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810177",
"pmid" : "19332456"
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"briefDesignDescription" : "Apixaban vs. ASA in AF",
"abbreviation" : "AVERROES",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:33:40Z",
"pageid" : 1718,
"subspecialties" : "Cardiology;Neurology",
"statusUsableDate" : "2013-11-01",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "Apixaban better than ASA without increased bleeding in AF",
"expansion" : "Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment",
"published" : "2011-03-03",
"pageName" : "AVERROES",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007432",
"title" : "Apixaban in patients with atrial fibrillation",
"citation" : "Connolly SJ, et al. \"Apixaban in patients with atrial fibrillation\". The New England Journal of Medicine. 2011. 364(9):806-817.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007432",
"pmid" : "21309657"
},
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"pageName" : "AVERT",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1814468",
"expansion" : "Apixaban for the Prevention of Venous Thromboembolism in High-Risk Ambulatory Cancer Patients",
"published" : "2018-12-04",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1814468",
"pmid" : "30511879",
"title" : "Apixaban to Prevent Venous Thromboembolism in Patients with Cancer",
"citation" : "Carrier M, et al. \"Apixaban to Prevent Venous Thromboembolism in Patients with Cancer\". The New England Journal of Medicine. 2018. E-pub 2018-12-04:1-8.",
"timestamp" : "2019-02-05T14:44:30Z",
"pageid" : 3752,
"subspecialties" : "Hematology;Oncology",
"abbreviation" : "AVERT",
"briefDesignDescription" : "Apixaban for VTE prevention in cancer",
"trainingLevel" : "Resident",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"briefResultsDescription" : "Apixaban reduces risk of VTE, increases risk of bleeding",
"statusUsableDate" : "2019-01-31"
},
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"abbreviation" : "AVOID",
"briefDesignDescription" : "Supplemental oxygen in STEMI",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:33:41Z",
"pageid" : 2930,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2017-09-01",
"diseases" : "Myocardial Infarction",
"briefResultsDescription" : "No benefit from in non-hypoxemic patients with STEMI",
"expansion" : "Comparing Oxygen with normal air in patients with ST-Segment Elevation Myocardial Infarction who are not hypoxic.",
"published" : "2015-05-22",
"pageName" : "AVOID",
"fulltexturl" : "http://circ.ahajournals.org/content/131/24/2143",
"title" : "Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction",
"citation" : "Stub D, et al. \"Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction\". Circulation. 2015. 131(24):2143-2150.",
"pdfurl" : "http://circ.ahajournals.org/content/131/24/2143.full.pdf",
"pmid" : "26002889"
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"published" : "1987-07-23",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198707233170401",
"pageName" : "AZT Trial",
"citation" : "Fischl MA et al. \"The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex\". The New England Journal of Medicine. 1987. 317(4):185-191.",
"title" : "The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex",
"pmid" : "3299089",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198707233170401",
"trainingLevel" : "Student",
"briefDesignDescription" : "Zidovudine in HIV/AIDS",
"abbreviation" : "",
"subspecialties" : "Infectious Disease",
"pageid" : 1775,
"timestamp" : "2017-12-03T22:33:42Z",
"statusUsableDate" : "2014-01-01",
"briefResultsDescription" : "Zidovudine reduces mortality in HIV/AIDS",
"diseases" : "HIV"
},
{
"citation" : "Jondeau G, et al. \"B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode\". Eur Heart J. 2009. 30(18):2186-2192.",
"title" : "B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode",
"pdfurl" : "",
"pmid" : "19717851",
"published" : "2009-08-30",
"expansion" : "Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode",
"fulltexturl" : "https://doi.org/10.1093/eurheartj/ehp323",
"pageName" : "B-CONVINCED",
"statusUsableDate" : "2020-08-20",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Beta-blocker withdrawal not needed in ADHF",
"trainingLevel" : "Student",
"abbreviation" : "B-CONVINCED",
"briefDesignDescription" : "Beta-blocker withdrawal in ADHF",
"subspecialties" : "Cardiology",
"timestamp" : "2020-08-20T18:18:36Z",
"pageid" : 4250
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"pageName" : "BARI 2D",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805796",
"published" : "2009-06-11",
"expansion" : "Bypass Angioplasty Revascularization Investigation 2 Diabetes",
"pmid" : "19502645",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805796",
"title" : "A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease",
"citation" : "Frye RL, et al. \"A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease\". The New England Journal of Medicine. 2009. 360(24):2503-2515.",
"pageid" : 1471,
"timestamp" : "2017-12-03T22:33:47Z",
"subspecialties" : "Cardiology;Endocrinology",
"abbreviation" : "BARI 2D",
"briefDesignDescription" : "CABG/PCI vs. OMT in diabetes with CAD",
"trainingLevel" : "Resident",
"briefResultsDescription" : "CABG is superior to OMT in diabetics with CAD",
"diseases" : "Coronary Artery Disease;Diabetes Mellitus",
"statusUsableDate" : "2013-06-01"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Symptom-based asthma therapy",
"abbreviation" : "BASALT",
"subspecialties" : "Pulmonology",
"pageid" : 1864,
"timestamp" : "2017-12-03T22:33:48Z",
"statusUsableDate" : "2015-03-01",
"briefResultsDescription" : "Symptom-, biomarker-, and physician-based treatments are similar",
"diseases" : "Asthma",
"expansion" : "Best Adjustment Strategy for Asthma in the Long Term",
"published" : "2012-09-12",
"fulltexturl" : "http://bit.ly/1FNk0v0",
"pageName" : "BASALT",
"citation" : "Calhoun WJ, et al. \"Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial\". Journal of the American Medical Association. 2012. 308(10):987-997.",
"title" : "Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial",
"pmid" : "22968888",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/24854/joc120069_987_997.pdf"
},
{
"title" : "Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma",
"citation" : "Bishop MR, et al. \"Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma\". The New England Journal of Medicine. 2022. 368(7):629-639.",
"pmid" : "34904798",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2116596",
"expansion" : "",
"published" : "2022-02-17",
"pageName" : "BELINDA",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2116596",
"statusUsableDate" : "2023-12-14",
"briefResultsDescription" : "CART did not improve PFS compared to ASCT",
"diseases" : "Lymphoma;Aggressive B-cell lymphoma",
"abbreviation" : "BELINDA",
"briefDesignDescription" : "Tisa-cel vs. ASCT in R/R DLBCL",
"trainingLevel" : "Fellow",
"pageid" : 4462,
"timestamp" : "2023-12-15T03:08:03Z",
"subspecialties" : "Hematology;Oncology"
},
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"statusUsableDate" : "2016-02-01",
"briefResultsDescription" : "Benazepril improves renal outcomes in non-diabetic CKD",
"diseases" : "Chronic Kidney Disease",
"abbreviation" : "",
"briefDesignDescription" : "Benazepril in non-diabetic CKD",
"trainingLevel" : "Resident",
"pageid" : 2674,
"timestamp" : "2017-12-03T22:33:54Z",
"subspecialties" : "Nephrology",
"title" : "Effect and Safety of Benazepril for Advanced Chronic Renal Insufficiency",
"citation" : "Hou FF, et al. \"Effect and Safety of Benazepril for Advanced Chronic Renal Insufficiency\". The New England Journal of Medicine. 2006. 354(2):131-140.",
"pmid" : "16407508",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa053107",
"expansion" : "",
"published" : "2006-01-12",
"pageName" : "Benazepril in Severe CKD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa053107"
},
{
"citation" : "Goekoop-Ruiterman YP, et al. \"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis\". Arthritis & Rheumatism. 2005. 52(11):3381-3390.",
"title" : "Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis",
"pdfurl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/pdf",
"pmid" : "16258899",
"published" : "2005-11-01",
"expansion" : "Behandel-Strategeieën (\"treatment strategies\" in Dutch)",
"fulltexturl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/abstract",
"pageName" : "BeSt",
"statusUsableDate" : "2012-03-01",
"diseases" : "Rheumatoid Arthritis",
"briefResultsDescription" : "Combination therapy produces early functional improvement than DMARD alone",
"trainingLevel" : "Resident",
"abbreviation" : "BeSt",
"briefDesignDescription" : "DMARD ± prednisone or infliximab in RA",
"subspecialties" : "Rheumatology",
"timestamp" : "2022-04-17T20:47:43Z",
"pageid" : 77
},
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"abbreviation" : "BEST",
"briefDesignDescription" : "PCI vs. CABG for multivessel disease",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:33:49Z",
"pageid" : 2916,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2017-05-01",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "PCI inferior to CABG for multivessel disease",
"expansion" : "The Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation",
"published" : "2015-03-26",
"pageName" : "BEST",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1415447",
"title" : "Trial of everolimus-eluting stents or bypass surgery for coronary disease",
"citation" : "Reardon MJ, et al. \"Trial of everolimus-eluting stents or bypass surgery for coronary disease\". The New England Journal of Medicine. 2015. 372(13):1204-12.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1415447",
"pmid" : "25774645"
},
{
"diseases" : "Metabolic Acidosis;Critical Illness",
"briefResultsDescription" : "No improvement in death with sodium bicarb in ICU patients",
"statusUsableDate" : "2019-02-28",
"subspecialties" : "Critical Care",
"timestamp" : "2019-03-05T05:23:16Z",
"pageid" : 3721,
"trainingLevel" : "Resident",
"abbreviation" : "BICAR-ICU",
"briefDesignDescription" : "Bicarbonate in severe metabolic acidosis",
"pdfurl" : "",
"pmid" : "29910040",
"citation" : "Jaber S, et al. \"Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial\". The Lancet. 2018. 392(10141):31-40.",
"title" : "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial",
"fulltexturl" : "https://doi.org/10.1016/S0140-6736(18)31080-8",
"pageName" : "BICAR-ICU",
"published" : "2018-07-07",
"expansion" : "Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill: A Multiple Center Randomized Clinical Trial"
},
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"statusUsableDate" : "2017-06-01",
"briefResultsDescription" : "Biventricular pacing superior to right ventricular pacing in patients with CHF with AV block",
"diseases" : "Atrioventricular Block",
"abbreviation" : "BLOCK-HF",
"briefDesignDescription" : "RV pacing vs. BiV pacing in HF with AV block",
"trainingLevel" : "resident",
"pageid" : 2422,
"timestamp" : "2019-03-26T21:31:31Z",
"subspecialties" : "Cardiology",
"title" : "Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block",
"citation" : "Curtis A.B., et al. \"Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block\". The New England Journal of Medicine. 2013. 368(17):1585-1593.",
"pmid" : "23614585",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210356",
"published" : "2013-04-25",
"expansion" : "Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block",
"pageName" : "BLOCK-HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210356"
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"pageName" : "Blood Pressure Reduction in Black Barbershops",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1717250",
"published" : "2018-04-05",
"expansion" : "Blood-Pressure Reduction in Black Barbershops",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1717250",
"pmid" : "29527973",
"title" : "A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops",
"citation" : "Victor RG, et al. \"A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops\". The New England Journal of Medicine. 2018. 378(14):1291-1301.",
"timestamp" : "2025-07-28T00:00:39Z",
"pageid" : 3578,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "PharmD-guided BP reduction for Black men",
"abbreviation" : "Blood-Pressure Reduction in Black Barbershops",
"trainingLevel" : "Resident",
"diseases" : "Hypertension",
"briefResultsDescription" : "Pharmacist-guided BP management improves",
"statusUsableDate" : "2018-04-05"
},
{
"briefResultsDescription" : "Intensive BP control had fewer CVD events in DM",
"diseases" : "Diabetes Mellitus;Hypertension",
"statusUsableDate" : "2024-11-30",
"subspecialties" : "Cardiology;Endocrinology",
"pageid" : 5613,
"timestamp" : "2025-06-05T17:40:19Z",
"trainingLevel" : "student",
"abbreviation" : "BPROAD",
"briefDesignDescription" : "Intensive BP control in DM",
"pmid" : "39555827",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2412006",
"citation" : "Bi Y, et al. \"Intensive blood-pressure control in patients with type 2 diabetes\". The New England Journal of Medicine. 2024. e-pub 2024-11-6:1-13.",
"title" : "Intensive blood-pressure control in patients with type 2 diabetes",
"fulltexturl" : "",
"pageName" : "BPROAD",
"published" : "2024-11-16",
"expansion" : "Blood Pressure Control Target in Diabetes"
},
{
"timestamp" : "2018-01-17T21:45:20Z",
"pageid" : 2402,
"subspecialties" : "Cardiology;Hematology",
"briefDesignDescription" : "LMWH bridging for surgery in AF",
"abbreviation" : "BRIDGE",
"trainingLevel" : "Intern",
"diseases" : "Atrial Fibrillation;Stroke",
"briefResultsDescription" : "LMWH bridging didn't reduce VTE but increased bleeding",
"statusUsableDate" : "2015-07-01",
"pageName" : "BRIDGE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501035",
"expansion" : "Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for Elective Invasive Procedure or Surgery",
"published" : "2015-06-22",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501035",
"pmid" : "26095867",
"title" : "Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation",
"citation" : "Douketis JD, et al. \"Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2015. 373(9):823-33."
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1103782",
"pageName" : "BRIM-3",
"expansion" : "BRAF Inhibitor in Melanoma 3",
"published" : "2011-06-30",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1103782",
"pmid" : "21639808",
"citation" : "Chapman BP, et al. \"Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation\". The New England Journal of Medicine. 2011. 364(26):2507-2516.",
"title" : "Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation",
"subspecialties" : "Oncology",
"timestamp" : "2017-12-03T22:33:53Z",
"pageid" : 2391,
"trainingLevel" : "Fellow",
"abbreviation" : "BRIM-3",
"briefDesignDescription" : "Vemurafenib in BRAF V600+ melanoma",
"diseases" : "Melanoma",
"briefResultsDescription" : "Vemurafenib improves survival in BRAF V600-mutated melanoma",
"statusUsableDate" : "2015-07-01"
},
{
"citation" : "Packer DL, et al. \"Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation\". JAMA. 2019. 321(13):1261-1274.",
"title" : "Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation",
"pdfurl" : "",
"pmid" : "30874766",
"published" : "2019-04-11",
"expansion" : "Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2728676",
"pageName" : "CABANA",
"statusUsableDate" : "2019-04-11",
"diseases" : "Atrial Fibrillation",
"briefResultsDescription" : "Catheter ablation does not reduce cardiovascular events in patients with AF",
"trainingLevel" : "Resident",
"abbreviation" : "CABANA",
"briefDesignDescription" : "Catheter ablation vs. anti-arrhythmic therapy in AF",
"subspecialties" : "Cardiology",
"timestamp" : "2019-04-11T17:25:17Z",
"pageid" : 3950
},
{
"pageid" : 4141,
"timestamp" : "2024-08-29T19:09:38Z",
"subspecialties" : "Critical Care",
"abbreviation" : "CALORIES",
"briefDesignDescription" : "Early parenteral vs. enteral feeds in ICU",
"trainingLevel" : "Resident",
"briefResultsDescription" : "No difference between parenteral and enteral feeds in ICU",
"diseases" : "Critical Illness",
"statusUsableDate" : "2024-08-28",
"pageName" : "CALORIES",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1409860",
"expansion" : "",
"published" : "2014-10-30",
"pmid" : "25271389",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1409860",
"title" : "Trial of the route of early nutritional support in critically ill adults",
"citation" : "Harvey SE, et al. \"Trial of the route of early nutritional support in critically ill adults\". The New England Journal of Medicine. 2014. 371(18):1673-1684."
},
{
"statusUsableDate" : "2017-11-30",
"diseases" : "Rheumatoid Arthritis",
"briefResultsDescription" : "Intensive methotrexate dosing better than conventional",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Methotrexate strategies in RA",
"abbreviation" : "CAMERA",
"subspecialties" : "Rheumatology",
"timestamp" : "2017-12-04T00:13:32Z",
"pageid" : 2859,
"citation" : "Verstappen SM, et al. \"Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)\". Annals of the Rheumatic Diseases. 2007. 66(11):1443-1449.",
"title" : "Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)",
"pdfurl" : "http://ard.bmj.com/content/66/11/1443.full.pdf",
"pmid" : "17519278",
"published" : "2007-11-01",
"expansion" : "Computer Assisted Management in Early Rheumatoid Arthritis",
"fulltexturl" : "http://ard.bmj.com/content/66/11/1443.long",
"pageName" : "CAMERA"
},
{
"pdfurl" : "http://ajp.psychiatryonline.org/doi/pdf/10.1176/ajp.2006.163.5.805",
"pmid" : "16648320",
"title" : "The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder",
"citation" : "Lam RW, et al. \"The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder\". The American Journal of Psychiatry. 2006. 165(5):805-812.",
"pageName" : "Can-SAD",
"fulltexturl" : "http://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2006.163.5.805",
"published" : "2006-05-01",
"expansion" : null,
"diseases" : "Seasonal Affective Disorder;Depression",
"briefResultsDescription" : "No difference between light therapy and SSRI in SAD",
"statusUsableDate" : "2015-04-01",
"timestamp" : "2017-12-03T22:34:40Z",
"pageid" : 2173,
"subspecialties" : "Psychiatry",
"briefDesignDescription" : "Light therapy vs. SSRI for SAD",
"abbreviation" : "Can-SAD",
"trainingLevel" : "Intern"
},
{
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS014067360004561X.pdf",
"pmid" : "11356436",
"citation" : "Stiell IG, et al. \"The Canadian CT Head Rule for patients with minor head trauma\". The Lancet. 2001. 357(9266):1391-96.",
"title" : "The Canadian CT Head Rule for patients with minor head trauma",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)04561-X/fulltext",
"pageName" : "Canadian CT Head Rule",
"expansion" : "",
"published" : "2001-05-05",
"diseases" : "Trauma",
"briefResultsDescription" : "GCS score, skull fracture, emesis, age, amnesia, and mechanism predict risk",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Emergency Medicine;Neurology",
"timestamp" : "2012-06-13T05:04:26Z",
"pageid" : 93,
"trainingLevel" : "resident",
"briefDesignDescription" : "CT head rules for trauma",
"abbreviation" : ""
},
{
"published" : "2017-08-27",
"expansion" : "Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)",
"pageName" : "CANTOS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1707914",
"title" : "Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease",
"citation" : "Ridker PM, et al. \"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease\". The New England Journal of Medicine. 2017. 377(12):1119-1131.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1707914",
"pmid" : "28845751",
"abbreviation" : "CANTOS",
"briefDesignDescription" : "Canakinumab in patients with previous MI",
"trainingLevel" : "Resident",
"timestamp" : "2018-11-12T16:15:18Z",
"pageid" : 2964,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2017-10-01",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Canakinumab reduces cardiovascular events in patients with previous MI"
},
{
"abbreviation" : "CANVAS",
"briefDesignDescription" : "Canagliflozin for CV outcomes in T2DM",
"trainingLevel" : "intern",
"pageid" : 2952,
"timestamp" : "2022-10-13T17:45:18Z",
"subspecialties" : "Endocrinology;Cardiology;Nephrology",
"statusUsableDate" : "2017-08-01",
"briefResultsDescription" : "Canagliflozin reduces CV events compared to placebo in patients with type 2 diabetes",
"diseases" : "Diabetes Mellitus",
"published" : "2017-08-17",
"expansion" : "Canagliflozin Cardiovascular Assessment Study",
"pageName" : "CANVAS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611925",
"title" : "Canagliflozin and cardiovascular and renal events in type 2 diabetes",
"citation" : "Neal B, et al. \"Canagliflozin and cardiovascular and renal events in type 2 diabetes\". The New England Journal of Medicine. 2017. 377(7):644-657.",
"pmid" : "28605608",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611925"
},
{
"diseases" : "Pneumonia",
"briefResultsDescription" : "Beta-lactam alone is noninferior to quinolone or beta-lactam+macrolide",
"statusUsableDate" : "2018-03-08",
"subspecialties" : "Infectious Disease",
"timestamp" : "2018-03-08T18:31:23Z",
"pageid" : 2838,
"trainingLevel" : "Student",
"briefDesignDescription" : "Antibiotic strategies for PNA",
"abbreviation" : "CAP-START",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1406330",
"pmid" : "25830421",
"citation" : "Postma DF, et al. \"Antibiotic treatment strategies for community-acquired pneumonia in adults\". The New England Journal of Medicine. 2015. 372(14):1312-1323.",
"title" : "Antibiotic treatment strategies for community-acquired pneumonia in adults",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1406330",
"pageName" : "CAP-START",
"published" : "2015-04-02",
"expansion" : "Community-Acquired Pneumonia—Study on the Initial Treatment with Antibiotics of Lower Respiratory Tract Infections"
},
{
"statusUsableDate" : "2023-04-06",
"briefResultsDescription" : "Hydrocortisone lowers mortality in severe CAP",
"diseases" : "Pneumonia",
"trainingLevel" : "student",
"briefDesignDescription" : "Hydrocortisone in severe CAP",
"abbreviation" : "CAPE COD",
"subspecialties" : "Critical Care;Pulmonology",
"pageid" : 5318,
"timestamp" : "2023-04-24T20:34:11Z",
"citation" : "Dequin PF, et al. \"Hydrocortisone in severe community-acquired pneumonia\". The New England Journal of Medicine. 2023. Epub 2023-03-21:1-11.",
"title" : "Hydrocortisone in severe community-acquired pneumonia",
"pmid" : "36942789",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2215145",
"expansion" : "",
"published" : "2023-03-21",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2215145",
"pageName" : "CAPE COD"
},
{
"title" : "Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial",
"citation" : "Dargie HJ, et al. \"Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial\". The Lancet. 2001. 357(9266):1385-1390.",
"pmid" : "11356434",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(00)04560-8.pdf",
"expansion" : "Carvedilol Post-Infarct Survival Control in LV Dysfunction",
"published" : "2001-05-01",
"pageName" : "CAPRICORN",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)04560-8",
"statusUsableDate" : "2019-03-07",
"briefResultsDescription" : "Improved mortality with carvedilol post-MI with LVEF ≤40%",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "CAPRICORN",
"briefDesignDescription" : "Carvedilol post-MI with HFrEF",
"trainingLevel" : "resident",
"pageid" : 2944,
"timestamp" : "2019-03-15T15:10:50Z",
"subspecialties" : "Cardiology"
},
{
"statusUsableDate" : "2012-03-01",
"diseases" : "Stroke;Transient Ischemic Attack;Coronary Artery Disease",
"briefResultsDescription" : "Clopidogrel reduces risk of cardiovascular events",
"briefDesignDescription" : "Clopidogrel vs. aspirin in CV disease",
"abbreviation" : "CAPRIE",
"trainingLevel" : "Intern",
"timestamp" : "2023-03-30T18:14:36Z",
"pageid" : 7,
"subspecialties" : "Neurology;Cardiology",
"title" : "A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events",
"citation" : "Gent M, et al. \"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events\". The Lancet. 1996. 348(9038):1329-39.",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673696094573.pdf",
"pmid" : "8918275",
"published" : "1996-11-16",
"expansion" : "Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events",
"pageName" : "CAPRIE",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(96)09457-3/fulltext"
},
{
"statusUsableDate" : "2020-10-31",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"briefResultsDescription" : "Apixaban is noninferior to dalteparin for cancer VTE",
"abbreviation" : "CARVAGGIO",
"briefDesignDescription" : "Apixaban vs. dalteparin in cancer VTE",
"trainingLevel" : "resident",
"timestamp" : "2020-11-05T18:09:03Z",
"pageid" : 4265,
"subspecialties" : "Hematology;Oncology",
"title" : "Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer",
"citation" : "Agnelli G, et al. \"Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer\". The New England Journal of Medicine. 2020. 382:1599-607.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915103",
"pmid" : "32223112",
"published" : "2020-03-29",
"expansion" : "",
"pageName" : "CARAVAGGIO",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1915103"
},
{
"subspecialties" : "Cardiology;Preventive Medicine",
"timestamp" : "2017-12-03T22:33:59Z",
"pageid" : 1332,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Preop coronary revascularization if stable CAD",
"abbreviation" : "CARP",
"diseases" : "Coronary Artery Disease;Cardiac Risk Assessment",
"briefResultsDescription" : "Preop coronary revascularization doesn't reduce mortality",
"statusUsableDate" : "2015-09-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041905",
"pageName" : "CARP",
"expansion" : "",
"published" : "2004-12-30",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041905",
"pmid" : "15625331",
"citation" : "McFalls EO, et al. \"Coronary-artery revascularization before elective major vascular surgery\". The New England Journal of Medicine. 2004. 351(27):2795-2804.",
"title" : "Coronary-artery revascularization before elective major vascular surgery"
},
{
"pmid" : "23131078",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210357",
"title" : "Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome",
"citation" : "Bart BA, et al. \"Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome\". The New England Journal of Medicine. 2012. 367(24):2296-2304.",
"pageName" : "CARRESS-HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210357",
"expansion" : "Cardiorenal Rescue Study in Acute Decompensated Heart Failure",
"published" : "2012-12-13",
"briefResultsDescription" : "Ultrafiltration worse then meds in acute HF",
"diseases" : "Heart Failure",
"statusUsableDate" : "2013-05-01",
"pageid" : 1356,
"timestamp" : "2017-12-03T22:34:00Z",
"subspecialties" : "Cardiology",
"abbreviation" : "CARRESS-HF",
"briefDesignDescription" : "Ultrafiltration in decompensated HF",
"trainingLevel" : "Resident"
},
{
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"briefResultsDescription" : "Rivaroxaban did not reduce VTE",
"statusUsableDate" : "2019-03-07",
"timestamp" : "2019-05-23T17:55:30Z",
"pageid" : 3945,
"subspecialties" : "Hematology;Oncology",
"briefDesignDescription" : "Rivaroxaban for VTE prevention in cancer",
"abbreviation" : "CASSINI",
"trainingLevel" : "Resident",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1814630",
"pmid" : "30786186",
"title" : "Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer",
"citation" : "Khorana AA, et al. \"Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer\". The New England Journal of Medicine. 2019. 380(8):720-8.",
"pageName" : "CASSINI",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1814630",
"published" : "2019-02-21",
"expansion" : "Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer"
},
{
"briefResultsDescription" : "Antiarrhythmics increase mortality",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"statusUsableDate" : "2012-12-01",
"subspecialties" : "Cardiology",
"pageid" : 1110,
"timestamp" : "2017-12-03T22:34:01Z",
"trainingLevel" : "Resident",
"abbreviation" : "CAST I",
"briefDesignDescription" : "Antiarrhythmics post-MI",
"pmid" : "1900101",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199103213241201",
"citation" : "Echt DS, et al. \"Mortality and morbidity in patients receiving encainide, flecainide, or placebo\". The New England Journal of Medicine. 1991. 324(12):781-788.",
"title" : "Mortality and morbidity in patients receiving encainide, flecainide, or placebo",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199103213241201",
"pageName" : "CAST I",
"published" : "1991-03-21",
"expansion" : "Cardiac Arrhythmia Suppression Trial"
},
{
"statusUsableDate" : "2018-02-08",
"briefResultsDescription" : "Catheter ablation superior to standard therapy in AF and HF",
"diseases" : "Atrial Fibrillation",
"trainingLevel" : "Resident",
"abbreviation" : "CASTLE-AF",
"briefDesignDescription" : "Catheter ablation vs. standard therapy in AF+HF",
"subspecialties" : "Cardiology",
"pageid" : 3533,
"timestamp" : "2018-08-10T15:33:15Z",
"citation" : "Marrouche NF, et al. \"Catheter Ablation for Atrial Fibrillation with Heart Failure\". The New England Journal of Medicine. 2018. 378(5):417-27.",
"title" : "Catheter Ablation for Atrial Fibrillation with Heart Failure",
"pmid" : "29385358",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1707855",
"published" : "2018-02-01",
"expansion" : "Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1707855",
"pageName" : "CASTLE-AF"
},
{
"statusUsableDate" : "2012-06-01",
"briefResultsDescription" : "Olanzapine ↓discontinuations but ↑metabolic syndrome, and perphenazine ˜ atypicals",
"diseases" : "Schizophrenia",
"trainingLevel" : "Resident",
"abbreviation" : "CATIE",
"briefDesignDescription" : "Antipsychotics in schizophrenia",
"subspecialties" : "Psychiatry",
"pageid" : 419,
"timestamp" : "2017-12-03T22:34:03Z",
"citation" : "Lieberman JA, et al. \"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia\". The New England Journal of Medicine. 2005. 353(12):1209-23.",
"title" : "Effectiveness of antipsychotic drugs in patients with chronic schizophrenia",
"pmid" : "16172203",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa051688",
"expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness",
"published" : "2005-09-22",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa051688",
"pageName" : "CATIE"
},
{
"published" : "2006-10-12",
"expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness–Alzheimer's Disease",
"pageName" : "CATIE-AD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061240",
"title" : "Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease",
"citation" : "Schneider LS, et al. \"Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease\". The New England Journal of Medicine. 2006. 355(15):1525-38.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061240",
"pmid" : "17035647",
"briefDesignDescription" : "Antipsychotics in dementia with psychosis",
"abbreviation" : "CATIE-AD",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:34:04Z",
"pageid" : 2724,
"subspecialties" : "Psychiatry",
"statusUsableDate" : "2016-04-01",
"diseases" : "Dementia;Alzheimer Disease;Psychosis",
"briefResultsDescription" : "Antipsychotics no better than placebo"
},
{
"pageName" : "CATT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102673",
"published" : "2011-05-19",
"expansion" : "Comparison of Age-Related Macular Degeneration Treatment Trails",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102673",
"pmid" : "21526923",
"title" : "Ranibizumab and bevacizumab for neovascular age-related macular degeneration",
"citation" : "The CATT Research Group Writers. \"Ranibizumab and bevacizumab for neovascular age-related macular degeneration\". The New England Journal of Medicine. 2011. 364(20):1897-1908.",
"timestamp" : "2017-12-03T22:34:05Z",
"pageid" : 2250,
"subspecialties" : "Ophthalmology",
"abbreviation" : "CATT",
"briefDesignDescription" : "Ranibizumab vs. bevacizumab for macular degeneration",
"trainingLevel" : "Resident",
"diseases" : "Macular Degeneration",
"briefResultsDescription" : "Ranibizumab vs. bevacizumab similar even when comparing monthly vs. PRN scheduling",
"statusUsableDate" : "2014-10-01"
},
{
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Cangrelor during urgent or elective PCI",
"abbreviation" : "CHAMPION PHOENIX",
"subspecialties" : "Cardiology",
"pageid" : 2935,
"timestamp" : "2025-07-25T00:26:24Z",
"statusUsableDate" : "2017-06-01",
"briefResultsDescription" : "Cangrelor reduces rate of ischemic events during PCI",
"diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
"expansion" : "Cangrelor versus standard therapy to achieve optimal management of platelet inhibition",
"published" : "2013-04-04",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300815",
"pageName" : "CHAMPION PHOENIX",
"citation" : "Bhatt DL, et al. \"Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events\". The New England Journal of Medicine. 2013. 368(14):1303-1313.",
"title" : "Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events",
"pmid" : "23473369",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300815"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "ASA/clopidogrel vs. ASA in TIA/stroke",
"abbreviation" : "CHANCE",
"subspecialties" : "Neurology",
"timestamp" : "2020-01-03T00:19:05Z",
"pageid" : 1530,
"statusUsableDate" : "2013-07-01",
"diseases" : "Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "ASA/clopidogrel decreases stroke rates compared to ASA alone in TIA and high-risk CVA",
"expansion" : "Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events",
"published" : "2013-07-04",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1215340",
"pageName" : "CHANCE",
"citation" : "Wang Y, et al. \"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack\". The New England Journal of Medicine. 2013. 369(1):11-19.",
"title" : "Clopidogrel with aspirin in acute minor stroke or transient ischemic attack",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1215340",
"pmid" : "23803136"
},
{
"diseases" : "Cardiovascular Disease;Stroke;Myocardial Infarction;Acute Coronary Syndrome",
"briefResultsDescription" : "Combination therapy no better than aspirin alone, more bleeding",
"statusUsableDate" : "2014-10-01",
"subspecialties" : "Cardiology",
"timestamp" : "2018-03-08T18:57:50Z",
"pageid" : 2175,
"trainingLevel" : "Resident",
"abbreviation" : "CHARISMA",
"briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin for CV prevention",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa060989",
"pmid" : "16531616",
"citation" : "Bhatt DL, et al. \"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events\". The New England Journal of Medicine. 2006. 354(16):1706-1717.",
"title" : "Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa060989",
"pageName" : "CHARISMA",
"expansion" : "Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance",
"published" : "2006-04-20"
},
{
"diseases" : "Heart Failure",
"briefResultsDescription" : "Adding ARB to ACE-I reduces CV events and HF hospitalizations",
"statusUsableDate" : "2014-08-01",
"timestamp" : "2017-12-03T22:34:11Z",
"pageid" : 2126,
"subspecialties" : "Cardiology",
"abbreviation" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Added",
"briefDesignDescription" : "ARB plus ACE-I in HF",
"trainingLevel" : "Intern",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603142833.pdf",
"pmid" : "13678869",
"title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial",
"citation" : "McMurray JJ, et al. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial\". The Lancet. 2003. 362(9386):767-771.",
"pageName" : "CHARM-Added",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2914283-3/fulltext",
"published" : "2003-09-06",
"expansion" : null
},
{
"briefResultsDescription" : "ARBs reduce CV mortality and HF hospitalization in HFrEF",
"diseases" : "Heart Failure",
"statusUsableDate" : "2023-03-29",
"subspecialties" : "Cardiology",
"pageid" : 2416,
"timestamp" : "2023-03-30T17:58:17Z",
"trainingLevel" : "Intern",
"briefDesignDescription" : "ARBs in HFrEF",
"abbreviation" : "CHARM-Alternative",
"pmid" : "13678870",
"pdfurl" : "",
"citation" : "Granger CB, et al. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial\". The Lancet. 2003. 362(9386):772-776.",
"title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial",
"fulltexturl" : "https://doi.org/10.1016/s0140-6736(03)14284-5",
"pageName" : "CHARM-Alternative",
"published" : "2003-09-06",
"expansion" : ""
},
{
"pmid" : "13678871",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14285-7.pdf",
"title" : "Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial",
"citation" : "Yusuf S, et al. \"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial\". The Lancet. 2003. 362(9386):777-781.",
"pageName" : "CHARM-Preserved",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14285-7/fulltext",
"published" : "2003-09-06",
"expansion" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved",
"briefResultsDescription" : "Candesartan modestly reduces HF admissions but does not affect CV mortality",
"diseases" : "Heart Failure",
"statusUsableDate" : "2015-06-01",
"pageid" : 2381,
"timestamp" : "2017-12-03T22:34:16Z",
"subspecialties" : "Cardiology",
"abbreviation" : "CHARM-Preserved",
"briefDesignDescription" : "ARBs in HFpEF",
"trainingLevel" : "Intern"
},
{
"pmid" : "22658127",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200690",
"citation" : "Topalian SL, et al. \"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer\". The New England Journal of Medicine. 2012. 366(26):2443-54.",
"title" : "Safety, activity, and immune correlates of anti-PD-1 antibody in cancer",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200690",
"pageName" : "CheckMate-003",
"expansion" : "",
"published" : "2012-06-28",
"briefResultsDescription" : "Nivolumab was well tolerated, yielded durable remissions in about 30% of patients",
"diseases" : "Melanoma;Lung Cancer;Renal Cell Carcinoma",
"statusUsableDate" : "2014-10-01",
"subspecialties" : "Oncology",
"pageid" : 2220,
"timestamp" : "2017-12-03T22:34:42Z",
"trainingLevel" : "Resident",
"abbreviation" : "",
"briefDesignDescription" : "Nivolumab in solid tumors"
},
{
"expansion" : "CHOICE is not an abbreviation per a communication with the research team",
"published" : "2014-10-02",
"pageName" : "CHOICE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1400506",
"title" : "Provision of no-cost, long-acting contraception and teenage pregnancy",
"citation" : "Secura GM, et al. \"Provision of no-cost, long-acting contraception and teenage pregnancy\". The New England Journal of Medicine. 2014. 371(14):1316-1326.",
"pmid" : "25271604",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1400506",
"abbreviation" : "CHOICE",
"briefDesignDescription" : "Free long-acting reversible contraception in teens",
"trainingLevel" : "Student",
"pageid" : 2233,
"timestamp" : "2017-12-03T22:34:18Z",
"subspecialties" : "Gynecology;Preventive Medicine;Obstetrics",
"statusUsableDate" : "2014-10-01",
"briefResultsDescription" : "LARC reduced pregnancy, live births, and abortions",
"diseases" : "Unplanned Pregnancy"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa065485",
"pmid" : "17108343",
"title" : "Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease",
"citation" : "Singh AK, et al. \"Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease\". The New England Journal of Medicine. 2006. 355(20):2085-2098.",
"pageName" : "CHOIR",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa065485",
"expansion" : "Correction of Hemoglobin and Outcomes in Renal Insufficiency",
"published" : "2006-11-16",
"diseases" : "Chronic Kidney Disease;Anemia",
"briefResultsDescription" : "Increased morbidity/mortality with higher hgb targets",
"statusUsableDate" : "2012-05-01",
"timestamp" : "2019-02-21T16:44:19Z",
"pageid" : 422,
"subspecialties" : "Nephrology;Hematology",
"briefDesignDescription" : "EPO in CKD with anemia",
"abbreviation" : "CHOIR",
"trainingLevel" : "Resident"
},
{
"title" : "The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial",
"citation" : "CIBIS-II Writers. \"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial\". The Lancet. 1999. 353(9146):9-13.",
"pdfurl" : "",
"pmid" : "10023943",
"published" : "1999-01-02",
"expansion" : "",
"pageName" : "CIBIS-II",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140673698111819",
"statusUsableDate" : "2023-01-30",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Bisoprolol lowers mortality in HFrEF",
"abbreviation" : "CIBIS-II",
"briefDesignDescription" : "Bisoprolol in HFrEF",
"trainingLevel" : "Student",
"timestamp" : "2023-02-02T19:39:17Z",
"pageid" : 2436,
"subspecialties" : "Cardiology"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Low-dose MTX for secondary prevention of CAD",
"abbreviation" : "CIRT",
"subspecialties" : "Cardiology",
"pageid" : 3739,
"timestamp" : "2025-05-22T17:32:54Z",
"statusUsableDate" : "2018-11-14",
"briefResultsDescription" : "Low-dose methotrexate not superior to placebo for secondary prevention of CAD",
"diseases" : "Coronary Artery Disease",
"published" : "2018-11-10",
"expansion" : "Cardiovascular Inflammation Reduction Trial",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1809798",
"pageName" : "CIRT",
"citation" : "Ridker PM, et al. \"Low-dose methotrexate for the prevention of atherosclerotic events\". The New England Journal of Medicine. 2018. epub 2018-11-10:1-11.",
"title" : "Low-dose methotrexate for the prevention of atherosclerotic events",
"pmid" : "30415610",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1809798"
},
{
"timestamp" : "2017-12-03T22:34:21Z",
"pageid" : 1093,
"subspecialties" : "Neurology;Cardiology",
"abbreviation" : "CLOSURE I",
"briefDesignDescription" : "PFO closure in cryptogenic stroke",
"trainingLevel" : "Fellow",
"diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
"briefResultsDescription" : "PFO closure does not reduce recurrent stroke",
"statusUsableDate" : "2013-01-01",
"pageName" : "CLOSURE I",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009639",
"expansion" : "Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale",
"published" : "2012-03-15",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009639",
"pmid" : "22417252",
"title" : "Closure or medical therapy for cryptogenic stroke with patent foramen ovale",
"citation" : "Furlan AJ, et al. \"Closure or medical therapy for cryptogenic stroke with patent foramen ovale\". The New England Journal of Medicine. 2012. 366(11):991-999."
},
{
"published" : "2003-07-10",
"expansion" : "Comparison of Low Molecular Weight Heparin Versus Oral Anticoagulant Therapy for Long Term Anticoagulation in Cancer Patients With Venous Thromboembolism",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa025313",
"pageName" : "CLOT",
"citation" : "Lee AY, et al. \"Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer\". The New England Journal of Medicine. 2003. 349(2):146-53.",
"title" : "Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa025313",
"pmid" : "12853587",
"trainingLevel" : "Intern",
"abbreviation" : "CLOT",
"briefDesignDescription" : "LMWH vs. warfarin in cancer VTE",
"subspecialties" : "Hematology;Oncology",
"timestamp" : "2018-04-14T12:16:19Z",
"pageid" : 13,
"statusUsableDate" : "2012-03-01",
"diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
"briefResultsDescription" : "LMWH reduces VTE recurrence in cancer VTE without increasing bleeding risk"
},
{
"published" : "2018-09-23",
"expansion" : "Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation",
"pageName" : "COAPT",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1806640",
"title" : "Transcatheter Mitral Valve Repair in Patients with Heart Failure",
"citation" : "Stone GW, et al. \"Transcatheter Mitral Valve Repair in Patients with Heart Failure\". The New England Journal of Medicine. 2018. 379:2307-2318.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1806640",
"pmid" : "30280640",
"abbreviation" : "COAPT",
"briefDesignDescription" : "Mitra Clip for HF-related MR",
"trainingLevel" : "Resident",
"timestamp" : "2021-04-29T17:37:05Z",
"pageid" : 3714,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2018-12-19",
"diseases" : "Mitral Regurgitation",
"briefResultsDescription" : "Mitra Clip reduces HF hospitalization rate in HF-related MR"
},
{
"title" : "Clopidogrel with or without omeprazole in coronary artery disease",
"citation" : "Bhatt DL, et al. \"Clopidogrel with or without omeprazole in coronary artery disease\". The New England Journal of Medicine. 2010. 363(20):1909-17.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007964",
"pmid" : "20925534",
"expansion" : "Clopidogrel and the Optimization of Gastrointestinal Events Trial",
"published" : "2010-11-11",
"pageName" : "COGENT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007964",
"statusUsableDate" : "2012-04-01",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "PPIs reduce bleeding but do not increase CV events when given with clopidogrel",
"briefDesignDescription" : "PPI plus clopidogrel in CAD",
"abbreviation" : "COGENT",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:34:23Z",
"pageid" : 313,
"subspecialties" : "Cardiology"
},
{
"statusUsableDate" : "2019-11-24",
"briefResultsDescription" : "Colchicine superior to placebo in ACS",
"diseases" : "Acute Coronary Syndrome",
"abbreviation" : "COLCOT",
"briefDesignDescription" : "Colchicine vs. placebo in ACS",
"trainingLevel" : "Resident",
"pageid" : 4145,
"timestamp" : "2021-02-18T20:37:27Z",
"subspecialties" : "Cardiology",
"title" : "Efficacy and safety of low-dose colchicine after myocardial infarction",
"citation" : "Tardif J, et al. \"Efficacy and safety of low-dose colchicine after myocardial infarction\". The New England Journal of Medicine. 2019. 381(26):2497-2505.",
"pmid" : "31733140",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1912388",
"published" : "2019-11-16",
"expansion" : "Colchicine Cardiovascular Outcomes Trial",
"pageName" : "COLCOT",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1912388"
},
{
"pageName" : "COLONPREV",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1108895",
"expansion" : null,
"published" : "2012-02-23",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1108895",
"pmid" : "22356323",
"title" : "Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening",
"citation" : "Quintero E, et al. \"Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening\". The New England Journal of Medicine. 2012. 366(8):697-706.",
"timestamp" : "2021-09-16T13:55:19Z",
"pageid" : 2393,
"subspecialties" : "Preventive Medicine;Gastroenterology;Oncology",
"briefDesignDescription" : "FIT vs. colonoscopy for colon cancer screening",
"abbreviation" : "COLONPREV",
"trainingLevel" : "Resident",
"diseases" : "Colorectal Cancer",
"briefResultsDescription" : "FIT is noninferior to colonoscopy for detecting colon cancer",
"statusUsableDate" : "2016-07-01"
},
{
"diseases" : "Heart Failure",
"briefResultsDescription" : "Carvedilol extends survival in HFrEF",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Cardiology",
"timestamp" : "2015-08-24T04:36:50Z",
"pageid" : 121,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Carvedilol vs. metoprolol in HFrEF",
"abbreviation" : "COMET",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603138007.pdf",
"pmid" : "12853193",
"citation" : "Poole-Wilson PA, et al. \"Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial\". The Lancet. 2003. 362(9377):7-13.",
"title" : "Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)13800-7/fulltext",
"pageName" : "COMET",
"published" : "2003-07-05",
"expansion" : "Carvedilol Or Metoprolol European Trial"
},
{
"title" : "Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial",
"citation" : "Chen ZM, et al. \"Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial\". The Lancet. 2005. 366(9497):1622-1632.",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673605676611.pdf",
"pmid" : "16271643",
"published" : "2005-11-05",
"expansion" : "ClOpidogrel and Metoprolol in Myocardial Infarction Trial / Second Chinese Cardiac Study",
"pageName" : "COMMIT",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67661-1/fulltext",
"statusUsableDate" : "2013-05-01",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"briefResultsDescription" : "High-dose IV and PO metoprolol increases cardiogenic shock",
"briefDesignDescription" : "Metoprolol in acute MI",
"abbreviation" : "COMMIT/CCS-2",
"trainingLevel" : "Student",
"timestamp" : "2018-03-08T18:56:18Z",
"pageid" : 1451,
"subspecialties" : "Cardiology"
},
{
"pageid" : 3543,
"timestamp" : "2018-03-12T00:27:10Z",
"subspecialties" : "Cardiology",
"abbreviation" : "Compare-Acute",
"briefDesignDescription" : "Multivessel PCI vs. FFR-guided complete revascularization",
"trainingLevel" : "Resident",
"briefResultsDescription" : "FFR-guided complete revascularization superior to infarct-related artery only PCI",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2018-03-11",
"pageName" : "Compare-Acute",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMc1706275",
"expansion" : "",
"published" : "2017-03-30",
"pmid" : "28745981",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMc1706275",
"title" : "Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction",
"citation" : "Smits PC, et al. \"Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction\". The New England Journal of Medicine. 2017. 376(13):1234-1244."
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1709118",
"pageName" : "COMPASS",
"published" : "2017-08-27",
"expansion" : "Cardiovascular Outcomes for People Using Anticoagulation Stratgies",
"pmid" : "28844192",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1709118",
"citation" : "Eikelboom JW et al. \"Rivaroxaban with or without aspirin in stable cardiovascular disease\". The New England Journal of Medicine. 2017. 377(14):1319-1330.",
"title" : "Rivaroxaban with or without aspirin in stable cardiovascular disease",
"subspecialties" : "Cardiology",
"pageid" : 2955,
"timestamp" : "2024-08-27T16:42:59Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Rivaroxaban, ASA, or both in stable CAD",
"abbreviation" : "COMPASS",
"briefResultsDescription" : "Rivaroxaban + ASA superior to placebo + ASA for secondary prevention of CAD",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2017-09-01"
},
{
"title" : "Effects of enalapril on mortality in severe congestive heart failure, results of the cooperative north Scandinavian enalapril survival study",
"citation" : "CONSENSUS Trial Study Group. \"Effects of enalapril on mortality in severe congestive heart failure, results of the cooperative north Scandinavian enalapril survival study\". The New England Journal of Medicine. 1987. 316(23):1429-35.",
"pmid" : "2883575",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198706043162301",
"expansion" : "Cooperative North Scandinavian Enalapril Survival Study",
"published" : "1987-06-04",
"pageName" : "CONSENSUS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198706043162301",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Enalapril ↓mortality in NYHA class IV HFrEF",
"diseases" : "Heart Failure",
"briefDesignDescription" : "Enalapril in severe HFrEF",
"abbreviation" : "CONSENSUS",
"trainingLevel" : "Intern",
"pageid" : 18,
"timestamp" : "2021-02-20T21:38:07Z",
"subspecialties" : "Cardiology"
},
{
"pageName" : "COPERNICUS",
"fulltexturl" : "http://circ.ahajournals.org/content/106/17/2194.full",
"published" : "2002-10-22",
"expansion" : "Carvedilol Prospective Randomized Cumulative Survival",
"pdfurl" : "http://circ.ahajournals.org/content/106/17/2194.full.pdf",
"pmid" : "12390947",
"title" : "Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure",
"citation" : "Packer M, et al. \"Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure\". Circulation. 2002. 106(17):2194-9.",
"timestamp" : "2014-06-13T04:33:43Z",
"pageid" : 42,
"subspecialties" : "Cardiology",
"abbreviation" : "COPERNICUS",
"briefDesignDescription" : "Carvedilol in HFrEF",
"trainingLevel" : "Intern",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Carvedilol reduces mortality and HF hospitalizations in severe NYHA class III-IV HFrEF",
"statusUsableDate" : "2012-03-01"
},
{
"diseases" : "Cardiovascular Disease;Chronic Kidney Disease;Hypertension",
"briefResultsDescription" : "No difference in clinical outcomes",
"statusUsableDate" : "2019-11-07",
"timestamp" : "2019-11-07T19:27:29Z",
"pageid" : 2388,
"subspecialties" : "Nephrology;Cardiology",
"briefDesignDescription" : "Stenting vs. medical therapy in RAS",
"abbreviation" : "CORAL",
"trainingLevel" : "Intern",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310753",
"pmid" : "24245566",
"title" : "Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis",
"citation" : "Cooper CJ, et al. \"Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis\". The New England Journal of Medicine. 2014. 370(1):13-22.",
"pageName" : "CORAL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310753",
"expansion" : "Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis",
"published" : "2014-01-02"
},
{
"abbreviation" : "CORONA",
"briefDesignDescription" : "Rosuvastatin in ischemic HFrEF",
"trainingLevel" : "Resident",
"pageid" : 524,
"timestamp" : "2017-12-03T22:34:30Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2012-07-01",
"briefResultsDescription" : "Statins confer no survival benefit but may reduce hospitalizations in ischemic HFrEF",
"diseases" : "Heart Failure;Hyperlipidemia",
"published" : "2007-11-29",
"expansion" : "Controlled Rosuvastatin Multinational Trial in Heart Failure",
"pageName" : "CORONA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706201",
"title" : "Rosuvastatin in Older Patients with Systolic Heart Failure",
"citation" : "Kjekshus J, et al. \"Rosuvastatin in Older Patients with Systolic Heart Failure\". The New England Journal of Medicine. 2007. 357(22):2248-61.",
"pmid" : "17984166",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706201"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa071366",
"pageName" : "CORTICUS",
"expansion" : "Corticosteroid Therapy of Septic Shock",
"published" : "2008-01-10",
"pmid" : "18184957",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa071366",
"citation" : "Sprung CL, et al. \"Hydrocortisone therapy for patients with septic shock\". New England Journal of Medicine. 2008. 358(2):111-24.",
"title" : "Hydrocortisone therapy for patients with septic shock",
"subspecialties" : "Critical Care;Endocrinology",
"pageid" : 4,
"timestamp" : "2018-03-03T22:13:51Z",
"trainingLevel" : "Student",
"abbreviation" : "CORTICUS",
"briefDesignDescription" : "Hydrocortisone in septic shock",
"briefResultsDescription" : "Improved survival of hydrocortisone in septic shock",
"diseases" : "Sepsis;Shock",
"statusUsableDate" : "2012-03-01"
},
{
"pageid" : 21,
"timestamp" : "2017-12-14T14:38:53Z",
"subspecialties" : "Cardiology",
"abbreviation" : "COURAGE",
"briefDesignDescription" : "PCI vs. medical therapy in CAD",
"trainingLevel" : "Student",
"briefResultsDescription" : "No difference between PCI and OMT in stable CAD",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2012-03-01",
"pageName" : "COURAGE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa070829",
"published" : "2007-04-12",
"expansion" : "Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation",
"pmid" : "17387127",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa070829",
"title" : "Optimal medical therapy with or without PCI for stable coronary disease",
"citation" : "Boden WE, et al. \"Optimal medical therapy with or without PCI for stable coronary disease\". The New England Journal of Medicine. 2007. 356:1503-16."
},
{
"statusUsableDate" : "2017-04-01",
"briefResultsDescription" : "Cranberry ineffective to prevent pyuria and bacteriuria",
"diseases" : "Bacteriuria;Pyuria",
"abbreviation" : "",
"briefDesignDescription" : "Cranberry in for prevention of pyuria and bacteriuria",
"trainingLevel" : "student",
"pageid" : 2900,
"timestamp" : "2017-12-03T22:34:43Z",
"subspecialties" : "Infectious Disease;Geriatrics",
"title" : "Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial",
"citation" : "Juthani-Mehta M, et al. \"Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial\". JAMA. 2016. 316(18):1879-1887.",
"pmid" : "27787564",
"pdfurl" : "",
"expansion" : "",
"published" : "2016-11-08",
"pageName" : "Cranberry for prevention of pyuria and bacteriuria",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.16141"
},
{
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Tranexamic acid reduces 4-week mortality",
"diseases" : "Trauma",
"trainingLevel" : "resident",
"briefDesignDescription" : "Tranexamic acid in trauma",
"abbreviation" : "CRASH-2",
"subspecialties" : "Emergency Medicine;Surgery;Hematology",
"pageid" : 490,
"timestamp" : "2022-12-01T18:56:37Z",
"citation" : "Shakur H, et al. \"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage\". The Lancet. 2010. 376(9734):23-32.",
"title" : "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage",
"pmid" : "20554319",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673610608355.pdf",
"expansion" : "Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2",
"published" : "2010-07-03",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960835-5/fulltext",
"pageName" : "CRASH-2"
},
{
"citation" : "Raje N, et al. \"Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma\". The New England Journal of Medicine. 2019. 380(18):1726-1737.",
"title" : "Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817226",
"pmid" : "31042825",
"expansion" : "",
"published" : "2019-05-02",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1817226",
"pageName" : "CRB-401",
"statusUsableDate" : "2022-06-16",
"diseases" : "Multiple Myeloma",
"briefResultsDescription" : "CRS 76%, ORR 85%, PFS 11.8 months",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Ide-cel CART in myeloma",
"abbreviation" : "CRB-401",
"subspecialties" : "Hematology;Oncology",
"timestamp" : "2022-06-17T05:34:20Z",
"pageid" : 4096
},
{
"briefDesignDescription" : "Canagliflozin in diabetic nephropathy",
"abbreviation" : "CREDENCE",
"trainingLevel" : "Resident",
"timestamp" : "2019-10-15T19:28:09Z",
"pageid" : 4088,
"subspecialties" : "Endocrinology;Nephrology",
"statusUsableDate" : "2019-07-31",
"diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
"briefResultsDescription" : "Canagliflozin reduces renal and CVD endpoints vs. placebo",
"published" : "2019-06-13",
"expansion" : "Canagliflozin and Renal Events in Diabetes and Nephropathy Clinical Evaluation",
"pageName" : "CREDENCE",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1811744",
"title" : "Canagliflozin and renal outcomes in diabetic nephropathy",
"citation" : "Perkovic V, et al. \"Canagliflozin and renal outcomes in diabetic nephropathy\". The New England Journal of Medicine. 2019. 380(24):2295-2306.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1811744",
"pmid" : "30990260"
},
{
"diseases" : "Carotid Stenosis;Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "No difference in stroke/MI/death; stenting ↑perioperative stroke but ↓perioperative MI",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2019-01-30T21:43:56Z",
"pageid" : 492,
"subspecialties" : "Surgery;Neurology;Cardiology",
"abbreviation" : "CREST",
"briefDesignDescription" : "Stenting vs. CEA in carotid stenosis",
"trainingLevel" : "Intern",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0912321",
"pmid" : "20505173",
"title" : "Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis",
"citation" : "Brott TG, et al. \"Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis\". The New England Journal of Medicine. 2010. 363(1):11-23.",
"pageName" : "CREST",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0912321",
"published" : "2010-07-01",
"expansion" : "Carotid Revascularization Endarterectomy vs. Stenting Trial"
},
{
"published" : "2013-11-06",
"expansion" : "Colloids Versus Crystalloids for the Resuscitation of the Critically Ill",
"fulltexturl" : "http://bit.ly/1kLbQWJ",
"pageName" : "CRISTAL",
"citation" : "Annane D, et al. \"Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock\". The Journal of the American Medical Association. 2013. 310(17):1809-1817.",
"title" : "Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock",
"pmid" : "24108515",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/928522/joi130081.pdf",
"trainingLevel" : "resident",
"abbreviation" : "CRISTAL",
"briefDesignDescription" : "Colloids vs. crystalloids in shock",
"subspecialties" : "Critical Care",
"pageid" : 1768,
"timestamp" : "2017-12-03T22:34:32Z",
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Colloids no different from crystalloids in mortality",
"diseases" : "Shock"
},
{
"published" : "1993-11-11",
"expansion" : "Collaborative Study Group Captopril Trial",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199311113292004",
"pageName" : "CSG Captopril Trial",
"citation" : "Lewis EJ, et al. \"The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.\". The New England Journal of Medicine. 1993. 329(20):1456-1462.",
"title" : "The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.",
"pmid" : "8413456",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199311113292004",
"trainingLevel" : "Student",
"briefDesignDescription" : "Captopril in T1DM nephropathy",
"abbreviation" : "CSG Captopril Trial",
"subspecialties" : "Nephrology;Endocrinology",
"pageid" : 1591,
"timestamp" : "2021-04-22T22:10:39Z",
"statusUsableDate" : "2013-08-01",
"briefResultsDescription" : "Captopril reduces T1DM nephropathy progression",
"diseases" : "Diabetic Nephropathy;Diabetes Mellitus"
},
{
"title" : "PCI strategies in patients with acute myocardial infarction and cardiogenic shock",
"citation" : "Thiele H, et al. \"PCI strategies in patients with acute myocardial infarction and cardiogenic shock\". New England Journal of Medicine. 2017. epub 2017-10-30:1-13.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1710261#t",
"pmid" : "29083953",
"published" : "2017-10-30",
"expansion" : "Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock",
"pageName" : "CULPRIT-SHOCK",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1710261#t",
"statusUsableDate" : "2017-11-01",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Culprit-only PCI superior to multivessel PCI in cardiogenic shock",
"abbreviation" : "CULPRIT-SHOCK",
"briefDesignDescription" : "Culprit-only vs. multivessel PCI in cardiogenic shock",
"trainingLevel" : "Resident",
"timestamp" : "2018-08-28T15:50:00Z",
"pageid" : 2977,
"subspecialties" : "Cardiology"
},
{
"timestamp" : "2017-12-03T22:34:36Z",
"pageid" : 921,
"subspecialties" : "Cardiology",
"abbreviation" : "CURE",
"briefDesignDescription" : "Clopidogrel in UA/NSTEMI",
"trainingLevel" : "Resident",
"diseases" : "Acute Coronary Syndrome",
"briefResultsDescription" : "Clopidogrel reduces CV events but increases bleeding in UA/NSTEMI",
"statusUsableDate" : "2012-12-01",
"pageName" : "CURE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010746",
"published" : "2001-08-16",
"expansion" : "Clopidogrel in Unstable Angina to Prevent Recurrent Events",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010746",
"pmid" : "11519503",
"title" : "Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation",
"citation" : "Yusuf S, et al. \"Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation\". The New England Journal of Medicine. 2001. 345(7):494-502."
},
{
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Complete revascularization superior to culprit lesion-only revascularization",
"statusUsableDate" : "2017-02-01",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:34:45Z",
"pageid" : 2880,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Culprit lesion-only vs. complete revascularization",
"abbreviation" : "CvLPRIT",
"pdfurl" : "http://www.onlinejacc.org/content/accj/65/10/963.full.pdf?download",
"pmid" : "25766941",
"citation" : "Gershlick et al. \"Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease\". J Am Coll Cardiol. 2015. 65(10):963-72.",
"title" : "Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease",
"fulltexturl" : "http://www.onlinejacc.org/content/65/10/963",
"pageName" : "CvLPRIT",
"expansion" : "Complete Versus Lesion-Only Primary PCI Trial",
"published" : "2015-03-17"
},
{
"pmid" : "19451574",
"pdfurl" : "http://annals.org/data/Journals/AIM/20182/0000605-200905190-00004.pdf",
"citation" : "de Groot K, et al. \"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial\". Annals of Internal Medicine. 2009. 150(10):670-680.",
"title" : "Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial",
"fulltexturl" : null,
"pageName" : "CYCLOPS",
"published" : "2009-05-19",
"expansion" : null,
"briefResultsDescription" : "Pulse no worse than daily cyclophosphamide",
"diseases" : "Vasculitis",
"statusUsableDate" : "2015-03-01",
"subspecialties" : "Rheumatology;Nephrology",
"pageid" : 2338,
"timestamp" : "2017-12-03T22:34:37Z",
"trainingLevel" : "Fellow",
"abbreviation" : "CYCLOPS",
"briefDesignDescription" : "Pulse cyclophosphamide for ANCA vasculitis"
},
{
"pmid" : "25517706",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407764",
"citation" : "Walker N, et al. \"Cytisine versus nicotine for smoking cessation\". The New England Journal of Medicine. 2014. 371(25):2353-2362.",
"title" : "Cytisine versus nicotine for smoking cessation",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407764",
"pageName" : "Cytisine for Smoking Cessation",
"published" : "2014-12-18",
"expansion" : null,
"briefResultsDescription" : "Cytisine superior to NRT for abstinence at 1 month",
"diseases" : "Tobacco Abuse",
"statusUsableDate" : "2015-01-01",
"subspecialties" : "Pulmonology;Preventive Medicine",
"pageid" : 2319,
"timestamp" : "2018-01-13T01:32:16Z",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Cytisine vs. NRT for tobacco abuse",
"abbreviation" : null
},
{
"briefResultsDescription" : "Fewer vascular events with hematocrit <45% compared to 45-50%",
"diseases" : "Polycythemia Vera;Myeloproliferative Neoplasms",
"statusUsableDate" : "2016-02-01",
"pageid" : 2709,
"timestamp" : "2017-12-03T22:34:39Z",
"subspecialties" : "Hematology;Cardiology",
"abbreviation" : "CYTO-PV",
"briefDesignDescription" : "Hematocrit thresholds in PV",
"trainingLevel" : "Fellow",
"pmid" : "23216616",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208500",
"title" : "Cardiovascular events and intensity of treatment in polycythemia vera",
"citation" : "Marchioli R, et al. \"Cardiovascular events and intensity of treatment in polycythemia vera\". The New England Journal of Medicine. 2013. 368(1):22-33.",
"pageName" : "CYTO-PV",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208500",
"expansion" : "Cytoreductive Therapy in Polycythemia Vera",
"published" : "2013-01-03"
},
{
"trainingLevel" : "Intern",
"abbreviation" : "",
"briefDesignDescription" : "Scheduled daily sedation holidays in intubated patients",
"subspecialties" : "Critical Care;Pulmonology",
"timestamp" : "2017-12-03T22:35:01Z",
"pageid" : 1554,
"statusUsableDate" : "2013-08-01",
"diseases" : "Respiratory Failure",
"briefResultsDescription" : "Sedation holidays reduce intubated, ICU, hospital days",
"published" : "2000-05-18",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200005183422002",
"pageName" : "Daily ICU Sedation Holidays",
"citation" : "Kress JP, et al. \"Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation\". The New England Journal of Medicine. 2000. 342(20):1471-1477.",
"title" : "Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200005183422002",
"pmid" : "10816184"
},
{
"abbreviation" : "DANAMI-3 PRIMULTI",
"briefDesignDescription" : "Culprit lesion PCI vs. FFR in multivessel CAD",
"trainingLevel" : "Resident",
"timestamp" : "2018-05-31T17:39:19Z",
"pageid" : 3634,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2018-05-28",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "FFR-guided revascularization was superior to culprit-lesion only in multivessel CAD",
"published" : "2015-08-15",
"expansion" : "Third Danish Study of Optimal Acute Treatment of Patients with STEMI: Primary PCI in Multivessel Disease",
"pageName" : "DANAMI-3 PRIMULTI",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60648-1/fulltext",
"title" : "Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease",
"citation" : "Engstrom T, et al. \"Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease\". The Lancet. 2015. 386:665-71.",
"pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60648-1.pdf",
"pmid" : "26347918"
},
{
"statusUsableDate" : "2024-12-15",
"briefResultsDescription" : "Impella lowers 180d mortality if STEMI w/shock",
"diseases" : "Myocardial Infarction;Cardiogenic Shock",
"briefDesignDescription" : "Impella in STEMI w/cardiogenic shock",
"abbreviation" : "DanGer Shock",
"trainingLevel" : "Resident",
"pageid" : 5645,
"timestamp" : "2025-01-23T17:44:24Z",
"subspecialties" : "Cardiology",
"title" : "Microaxial flow pump or standard care in infarct-related cardiogenic shock",
"citation" : "Møller JE, et al. \"Microaxial flow pump or standard care in infarct-related cardiogenic shock\". The New England Journal of Medicine. 2024. 390(15):1382-1393.",
"pmid" : "38587239",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2312572",
"published" : "2024-04-18",
"expansion" : "Danish–German Cardiogenic Shock",
"pageName" : "DanGer Shock",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2312572"
},
{
"diseases" : "Ventricular Tachycardia",
"briefResultsDescription" : "ICD not better than standard of care in NICM and LVEF ≤35%",
"statusUsableDate" : "2016-09-01",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:34:48Z",
"pageid" : 2815,
"trainingLevel" : "Resident",
"abbreviation" : "DANISH",
"briefDesignDescription" : "ICD vs. standard care in NICM and LVEF ≤35%",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1608029",
"pmid" : "27571011",
"citation" : "Kober L, et al. \"Defibrillator implantation in patients with nonischemic systolic heart failure\". The New England Journal of Medicine. 2016. epub 2016-08-28:1-10.",
"title" : "Defibrillator implantation in patients with nonischemic systolic heart failure",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1608029",
"pageName" : "DANISH",
"expansion" : "Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality",
"published" : "2016-08-28"
},
{
"subspecialties" : "Nephrology;Cardiology",
"pageid" : 4363,
"timestamp" : "2021-05-28T02:47:35Z",
"trainingLevel" : "resident",
"briefDesignDescription" : "Dapagliflozin in CKD±T2DM",
"abbreviation" : "DAPA-CKD",
"briefResultsDescription" : "Dapagliflozin in CKD reduces renal endpoints and CVD death",
"diseases" : "Chronic Kidney Disease",
"statusUsableDate" : "2020-10-29",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2024816",
"pageName" : "DAPA-CKD",
"published" : "2020-10-08",
"expansion" : "Dapagliflozin in Chronic Kidney Disease",
"pmid" : "32970396",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024816",
"citation" : "Heerspink, et al. \"Dapagliflozin in patients with chronic kidney disease\". The New England Journal of Medicine. 2020. 383(13):1436-1446.",
"title" : "Dapagliflozin in patients with chronic kidney disease"
},
{
"statusUsableDate" : "2019-12-12",
"briefResultsDescription" : "Dapagliflozin reduces CV complications in HFrEF",
"diseases" : "Heart Failure",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Dapagliflozin in HFrEF",
"abbreviation" : "DAPA-HF",
"subspecialties" : "Cardiology;Endocrinology",
"pageid" : 4113,
"timestamp" : "2022-10-13T18:58:46Z",
"citation" : "McMurray JJV, et al. \"Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction\". The New England Journal of Medicine. 2019. 381(21):1995-2008.",
"title" : "Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction",
"pmid" : "31535829",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1911303",
"published" : "2019-11-21",
"expansion" : "Dapagliflozin in Heart Failure",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1911303",
"pageName" : "DAPA-HF"
},
{
"pmid" : "25399658",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409312",
"citation" : "Mauri L, et al. \"Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents\". The New England Journal of Medicine. 2014. 371(23):2155-2166.",
"title" : "Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409312",
"pageName" : "DAPT",
"published" : "2014-11-16",
"expansion" : "Dual Antiplatelet Therapy",
"briefResultsDescription" : "Longer duration reduces stent thrombosis, MI, stroke, but increases mortality/bleeding",
"diseases" : "Coronary Artery Disease;Myocardial Infarction;Stroke",
"statusUsableDate" : "2014-11-01",
"subspecialties" : "Cardiology",
"pageid" : 2264,
"timestamp" : "2017-12-03T22:34:50Z",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Aspirin/clopidogrel duration after PCI",
"abbreviation" : "DAPT"
},
{
"published" : "1997-04-17",
"expansion" : "Dietary Approaches to Stop Hypertension",
"pageName" : "DASH",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199704173361601",
"title" : "A clinical trial of the effects of dietary patterns on blood pressure",
"citation" : "Appel LJ, et al. \"A clinical trial of the effects of dietary patterns on blood pressure\". The New England Journal of Medicine. 1997. 336(16):1117-1124.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199704173361601",
"pmid" : "9099655",
"briefDesignDescription" : "DASH diet in HTN",
"abbreviation" : "DASH",
"trainingLevel" : "Student",
"timestamp" : "2020-09-22T18:22:21Z",
"pageid" : 90,
"subspecialties" : "Cardiology;Nephrology",
"statusUsableDate" : "2012-04-01",
"diseases" : "Hypertension",
"briefResultsDescription" : "DASH diet reduces SBP and DBP"
},
{
"published" : "2002-12-25",
"expansion" : "Dual-chamber pacing or ventricular backup pacing in ICD patients",
"pageName" : "DAVID",
"fulltexturl" : "http://jama.jamanetwork.com/article.aspx?volume",
"title" : "Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator",
"citation" : "Wilkoff BL, et al. \"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator\". Journal of the American Medical Association. 2002. 288(24):3115-3123.",
"pmid" : "12495391",
"pdfurl" : null,
"abbreviation" : "DAVID",
"briefDesignDescription" : "Dual-chamber vs. ventricular backup pacing in ICD patients",
"trainingLevel" : "Resident",
"pageid" : 2713,
"timestamp" : "2017-12-03T22:34:54Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2016-08-01",
"briefResultsDescription" : "Ventricular backup pacemaker superior to dual-chamber pacemaker",
"diseases" : "Bradycardia"
},
{
"title" : "Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct",
"citation" : "Nogueira RG, et al. \"Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct\". The New England Journal of Medicine. 2018. 378(1):11-21.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1706442",
"pmid" : "29129157",
"expansion" : "DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo",
"published" : "2018-01-04",
"pageName" : "DAWN",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1706442",
"statusUsableDate" : "2020-01-23",
"diseases" : "Stroke",
"briefResultsDescription" : "Thrombectomy improved 90-day outcomes compared to standard care",
"briefDesignDescription" : "Thrombectomy 6-24 hours after stroke",
"abbreviation" : "DAWN",
"trainingLevel" : "Resident",
"timestamp" : "2020-01-25T11:34:00Z",
"pageid" : 3529,
"subspecialties" : "Neurology"
},
{
"pageName" : "DCCT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309303291401",
"published" : "1993-09-30",
"expansion" : "Diabetes Control and Complications Trial",
"pmid" : "8366922",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309303291401",
"title" : "The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus",
"citation" : "DCCT Research Group. \"The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus\". The New England Journal of Medicine. 1993. 329(14):977-986.",
"pageid" : 135,
"timestamp" : "2012-09-16T11:23:12Z",
"subspecialties" : "Endocrinology",
"abbreviation" : "DCCT",
"briefDesignDescription" : "Intensive glycemic therapy in T1DM",
"trainingLevel" : "Student",
"briefResultsDescription" : "Intensive therapy delays microvascular but not macrovascular complications in T1DM",
"diseases" : "Diabetes Mellitus",
"statusUsableDate" : "2012-03-01"
},
{
"pageName" : "DEFINITE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa033088",
"published" : "2004-05-20",
"expansion" : "Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa033088",
"pmid" : "15152060",
"title" : "Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy",
"citation" : "Kadish A, et al. \"Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy\". The New England Journal of Medicine. 2004. 350(21):2151-2158.",
"timestamp" : "2014-06-13T04:45:33Z",
"pageid" : 84,
"subspecialties" : "Cardiology",
"abbreviation" : "DEFINITE",
"briefDesignDescription" : "ICD vs. medical therapy in HFrEF",
"trainingLevel" : "Resident",
"diseases" : "Heart Failure",
"briefResultsDescription" : "ICD reduced risk of arrhythmogenic sudden death, but not overall mortality",
"statusUsableDate" : "2012-03-01"
},
{
"title" : "Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial",
"citation" : "Hatta K, et al. \"Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial\". JAMA Psychiatry. 2014. 71(4):397-403.",
"pmid" : "24554232",
"pdfurl" : "",
"published" : "2014-04-01",
"expansion" : "Delirium Intervention Research for Improving Acute phase outcomes in Japan",
"pageName" : "DELIRIA-J",
"fulltexturl" : "http://jamanetwork.com/journals/jamapsychiatry/fullarticle/1831407",
"statusUsableDate" : "2021-09-30",
"briefResultsDescription" : "Ramelteon decreased risk of delirium in elderly patients",
"diseases" : "Delirium",
"abbreviation" : "DELIRIA-J",
"briefDesignDescription" : "Ramelteon vs. placebo to prevent delirium",
"trainingLevel" : "Resident",
"pageid" : 2806,
"timestamp" : "2021-10-04T20:25:15Z",
"subspecialties" : "Psychiatry;Geriatrics"
},
{
"diseases" : "Heart Failure",
"briefResultsDescription" : "Dapagliflozin reduces HF events in HFmrEF or HFpEF",
"statusUsableDate" : "2022-10-13",
"subspecialties" : "Cardiology",
"timestamp" : "2023-05-04T03:39:40Z",
"pageid" : 4921,
"trainingLevel" : "Resident",
"abbreviation" : "DELIVER",
"briefDesignDescription" : "Dapagliflozin in HFmrEF or HFpEF",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2206286",
"pmid" : "36027570",
"citation" : "Solomon SD, et al. \"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction\". The New England Journal of Medicine. 2022. 387(12):1089-1098.",
"title" : "Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2206286",
"pageName" : "DELIVER",
"expansion" : "Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure",
"published" : "2022-09-22"
},
{
"subspecialties" : "Cardiology",
"timestamp" : "2018-02-01T20:15:39Z",
"pageid" : 2970,
"trainingLevel" : "Student",
"abbreviation" : "DETO2X-AMI",
"briefDesignDescription" : "Oxygen for suspected MI",
"diseases" : "Myocardial Infarction",
"briefResultsDescription" : "Oxygen doesn't improve 1 year survival in MI",
"statusUsableDate" : "2017-10-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1706222",
"pageName" : "DETO2X-AMI",
"published" : "2017-09-28",
"expansion" : "Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1706222",
"pmid" : "28844200",
"citation" : "Hofmann R, et al. \"Oxygen therapy in suspected acute myocardial infarction\". The New England Journal of Medicine. 2017. 377(13):1240-1249.",
"title" : "Oxygen therapy in suspected acute myocardial infarction"
},
{
"diseases" : "Heart Failure",
"briefResultsDescription" : "Reduced hospitalizations, no mortality benefit",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Cardiology",
"timestamp" : "2014-06-13T04:50:56Z",
"pageid" : 89,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Digoxin in HFrEF",
"abbreviation" : "DIG",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199702203360801",
"pmid" : "9036306",
"citation" : "Gorlin R, et al. \"The effect of digoxin on mortality and morbidity in patients with heart failure\". The New England Journal of Medicine. 1997. 336(8):525-533.",
"title" : "The effect of digoxin on mortality and morbidity in patients with heart failure",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199702203360801",
"pageName" : "DIG",
"published" : "1997-02-20",
"expansion" : "Digitalis Investigation Group"
},
{
"pageName" : "DINAMIT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041489",
"expansion" : "Defibrillator in Acute Myocardial Infarction Trial",
"published" : "2004-12-09",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041489",
"pmid" : "15590950",
"title" : "Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction",
"citation" : "Hohnloser SH, et al. \"Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction\". The New England Journal of Medicine. 2004. 351(24):2481-2488.",
"timestamp" : "2020-09-14T19:26:41Z",
"pageid" : 1743,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "ICD for ICM shortly after MI",
"abbreviation" : "DINAMIT",
"trainingLevel" : "Resident",
"diseases" : "Heart Failure;Myocardial Infarction",
"briefResultsDescription" : "ICD reduces arrhythmia but not mortality",
"statusUsableDate" : "2016-04-01"
},
{
"briefDesignDescription" : "BMS vs. DES for saphenous vein graft PCI",
"abbreviation" : "DIVA",
"trainingLevel" : "Resident",
"pageid" : 3743,
"timestamp" : "2019-10-17T17:40:21Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2018-11-27",
"briefResultsDescription" : "BMS noninferior to DES for saphenous vein graft PCI",
"diseases" : "Coronary Artery Disease",
"published" : "2018-05-19",
"expansion" : "Rationale and design of the drug-eluting stents vs bare-metal stents in saphenous vein graft angioplasty",
"pageName" : "DIVA",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30801-8/fulltext",
"title" : "Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial",
"citation" : "Brilakis ES, et al. \"Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial\". Lancet. 2018. 391(10134):1997-2007.",
"pmid" : "29759512",
"pdfurl" : ""
},
{
"subspecialties" : "Hematology",
"pageid" : 4089,
"timestamp" : "2019-07-18T20:41:06Z",
"trainingLevel" : "Fellow",
"abbreviation" : "DODS",
"briefDesignDescription" : "D-dimer based anticoagulation discontinuation",
"briefResultsDescription" : "D-dimer based discontinuation effective in women, not for men",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"statusUsableDate" : "2019-07-18",
"fulltexturl" : "https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14458",
"pageName" : "DODS",
"expansion" : "D-dimer Optimal Duration Study",
"published" : "2019-01-18",
"pmid" : "31033194",
"pdfurl" : "https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14458",
"citation" : "Kearon C, et al. \"Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study\". Journal of Thrombosis and Hemostasis. 2019. 17(7):1144-52.",
"title" : "Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study"
},
{
"pageid" : 4066,
"timestamp" : "2019-05-23T17:58:08Z",
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Donor HCV positive heart and lung transplant",
"abbreviation" : "DONATE HCV",
"trainingLevel" : "Resident",
"briefResultsDescription" : "Donor HCV+ heart & lung transplant is feasible",
"diseases" : "Heart Failure;Respiratory Failure",
"statusUsableDate" : "2019-05-17",
"pageName" : "DONATE-HCV",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812406",
"expansion" : "Donors of Hepatitis C NAT Positive Thoracic Allografts for Transplantation Evaluation in Non-HCV Recipients",
"published" : "2019-04-25",
"pmid" : "30946553",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812406",
"title" : "Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients",
"citation" : "Woolley AE, et al. \"Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients\". The New England Journal of Medicine. 2019. 380(17):1606-1617."
},
{
"statusUsableDate" : "2013-06-01",
"diseases" : "Heart Failure",
"briefResultsDescription" : "High-dose better than low-dose, continuous infusions no better than intermittent IV boluses",
"briefDesignDescription" : "Diuretic dosing in acute HF",
"abbreviation" : "DOSE",
"trainingLevel" : "Intern",
"timestamp" : "2022-09-15T20:00:28Z",
"pageid" : 1457,
"subspecialties" : "Cardiology",
"title" : "Diuretic strategies in patients with acute decompensated heart failure",
"citation" : "Felker GM, et al. \"Diuretic strategies in patients with acute decompensated heart failure\". The New England Journal of Medicine. 2011. 364(9):797-805.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005419",
"pmid" : "21366472",
"expansion" : "Diuretic Optimization Strategies Evaluation",
"published" : "2011-03-03",
"pageName" : "DOSE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005419"
},
{
"subspecialties" : "Endocrinology",
"pageid" : 2494,
"timestamp" : "2018-05-31T18:34:46Z",
"trainingLevel" : "Student",
"abbreviation" : "DPP",
"briefDesignDescription" : "Metformin and intensive lifestyle in prediabetes",
"briefResultsDescription" : "Metformin and intensive lifestyle reduce incidence of diabetes",
"diseases" : "Prediabetes;Diabetes Mellitus",
"statusUsableDate" : "2018-05-31",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa012512",
"pageName" : "DPP",
"published" : "2002-02-07",
"expansion" : "Diabetes Prevention Program",
"pmid" : "11832527",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa012512",
"citation" : "Knowler WC, et al. \"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin\". The New England Journal of Medicine. 2002. 346(6):393-403.",
"title" : "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin"
},
{
"pageid" : 1579,
"timestamp" : "2017-12-03T22:35:03Z",
"subspecialties" : "Pediatrics;Dermatology",
"abbreviation" : "",
"briefDesignDescription" : "Duct tape vs. cryotherapy for warts",
"trainingLevel" : "Student",
"briefResultsDescription" : "Duct tape superior to cryotherapy for wart resolution",
"diseases" : "Warts",
"statusUsableDate" : "2013-07-01",
"pageName" : "Duct Tape for Treatment of the Common Wart",
"fulltexturl" : "",
"expansion" : "",
"published" : "2002-10-01",
"pmid" : "12361440",
"pdfurl" : "http://archpedi.jamanetwork.com/data/Journals/PEDS/5052/POA20075.pdf",
"title" : "The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)",
"citation" : "Focht DR, et al. \"The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)\". Archives of Pediatric and Adolescent Medicine. 2002. 156:971-974."
},
{
"title" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
"citation" : "Van Nood E, et al. \"Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile\". The New England Journal of Medicine. 2013. 368(5):407-415.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205037",
"pmid" : "23323867",
"published" : "2013-01-31",
"expansion" : "",
"pageName" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205037",
"statusUsableDate" : "2013-02-01",
"diseases" : "Clostridium difficile",
"briefResultsDescription" : "Fecal transplant better than vancomycin in C. difficile",
"abbreviation" : "",
"briefDesignDescription" : "Fecal transplant in C. difficile",
"trainingLevel" : "Intern",
"timestamp" : "2018-03-29T18:30:43Z",
"pageid" : 1226,
"subspecialties" : "Gastroenterology;Infectious Disease"
},
{
"diseases" : "Lung Cancer",
"briefResultsDescription" : "Palliative care ↑mood, ↑QOL, ↑survival, ↓aggressive care",
"statusUsableDate" : "2012-06-01",
"subspecialties" : "Oncology;Palliative Care",
"timestamp" : "2017-12-03T22:35:32Z",
"pageid" : 466,
"trainingLevel" : "Intern",
"abbreviation" : null,
"briefDesignDescription" : "Palliative care in NSCLC",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000678",
"pmid" : "20818875",
"citation" : "Temel JS, et al. \"Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer\". The New England Journal of Medicine. 2010. 363(8):733-742.",
"title" : "Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000678",
"pageName" : "Early Palliative Care",
"expansion" : null,
"published" : "2010-08-19"
},
{
"trainingLevel" : "Resident",
"abbreviation" : "Early TIPS",
"briefDesignDescription" : "Early TIPS in high-risk cirrhotic variceal bleeding",
"subspecialties" : "Gastroenterology;Interventional Radiology",
"timestamp" : "2018-08-30T17:24:07Z",
"pageid" : 2661,
"statusUsableDate" : "2018-08-30",
"diseases" : "Cirrhosis;Gastrointestinal Hemorrhage",
"briefResultsDescription" : "Early TIPS reduces rates of treatment failure and improves 1-year survival",
"published" : "2010-06-24",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910102",
"pageName" : "Early TIPS",
"citation" : "García-Pagán JC, et al. \"Early use of TIPS in patients with cirrhosis and variceal bleeding\". The New England Journal of Medicine. 2010. 362(25):2370-2379.",
"title" : "Early use of TIPS in patients with cirrhosis and variceal bleeding",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910102",
"pmid" : "20573925"
},
{
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
"pageName" : "EARLY-AF",
"expansion" : "Early Aggressive Invasive Intervention for Atrial Fibrillation",
"published" : "2021-01-28",
"pmid" : "33197159",
"pdfurl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
"citation" : "Andrade J, et al. \"Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation\". The New England Journal of Medicine. 2021. 384(4):305-315.",
"title" : "Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation",
"subspecialties" : "Cardiology",
"pageid" : 4406,
"timestamp" : "2021-11-08T18:52:31Z",
"trainingLevel" : "Resident",
"abbreviation" : "EARLY-AF",
"briefDesignDescription" : "Cryoablation vs. antiarrhythmics in AF",
"briefResultsDescription" : "Cryoablation with lower tachyarrhythmia recurrence than antiarrhythmics.",
"diseases" : "Atrial Fibrillation",
"statusUsableDate" : "2021-10-14"
},
{
"published" : "2012-06-28",
"expansion" : "Early Surgery versus Conventional Treatment in Infective Endocarditis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112843",
"pageName" : "EASE",
"citation" : "Kang DH, et al. \"Early surgery versus conventional treatment for infective endocarditis\". The New England Journal of Medicine. 2012. 366(26):2466-73.",
"title" : "Early surgery versus conventional treatment for infective endocarditis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112843",
"pmid" : "22738096",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Early surgery in endocarditis",
"abbreviation" : "EASE",
"subspecialties" : "Cardiology;Infectious Disease;Surgery",
"timestamp" : "2019-09-19T17:42:49Z",
"pageid" : 2939,
"statusUsableDate" : "2019-09-19",
"diseases" : "Endocarditis",
"briefResultsDescription" : "Early surgery improves outcomes in infective endocarditis"
},
{
"expansion" : "The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial",
"published" : "2020-10-01",
"fulltexturl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
"pageName" : "EAST-AFNET 4",
"citation" : "Kirchhof P, et al. \"Early rhythm-control therapy in patients with atrial fibrillation\". The New England Journal of Medicine. 2020. 383(14):1305-1316.",
"title" : "Early rhythm-control therapy in patients with atrial fibrillation",
"pmid" : "32865375",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
"trainingLevel" : "Resident",
"abbreviation" : "EAST-AFNET 4",
"briefDesignDescription" : "Early rhythm vs. rate control in AF",
"subspecialties" : "Cardiology",
"pageid" : 4399,
"timestamp" : "2025-05-15T20:16:15Z",
"statusUsableDate" : "2021-01-28",
"briefResultsDescription" : "Early rhythm control with fewer CVD events.",
"diseases" : "Atrial Fibrillation"
},
{
"abbreviation" : "ECASS III",
"briefDesignDescription" : "Alteplase 3-4.5h after stroke",
"trainingLevel" : "Intern",
"timestamp" : "2017-04-20T01:11:46Z",
"pageid" : 115,
"subspecialties" : "Neurology",
"statusUsableDate" : "2012-03-01",
"diseases" : "Stroke",
"briefResultsDescription" : "Alteplase improves neurological outcomes at 3 months",
"published" : "2008-09-25",
"expansion" : "European Cooperative Acute Stroke Study III",
"pageName" : "ECASS III",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804656",
"title" : "Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke",
"citation" : "Hacke W, et al. \"Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke\". The New England Journal of Medicine. 2008. 359(13):1317-1329.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804656",
"pmid" : "18815396"
},
{
"subspecialties" : "Emergency Medicine;Pediatrics;Neurology",
"timestamp" : "2024-06-27T17:56:09Z",
"pageid" : 4086,
"trainingLevel" : "Resident",
"abbreviation" : "EcLiPSE",
"briefDesignDescription" : "Levetiracetam vs. phenytoin in status epilepticus",
"diseases" : "Status Epilepticus",
"briefResultsDescription" : "Levetiracetam is non-inferior to phenytoin",
"statusUsableDate" : "2024-05-16",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30724-X/fulltext",
"pageName" : "EcLiPSE",
"expansion" : "Emergency treatment with Levetiracetam or Phenytoin in convulsive Status Epilepticus in children",
"published" : "2019-05-25",
"pdfurl" : "https://www.thelancet.com/action/showPdf?pii",
"pmid" : "31005385",
"citation" : "Lyttle MD, et al. \"Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.\". Lancet. 2019. 393(10186):2125-2134.",
"title" : "Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial."
},
{
"statusUsableDate" : "2015-08-01",
"briefResultsDescription" : "CEA improves outcomes in patients with ≥80% symptomatic carotid stenosis",
"diseases" : "Carotid Stenosis;Stroke",
"briefDesignDescription" : "CEA in symptomatic carotid stenosis",
"abbreviation" : "ECST",
"trainingLevel" : "Intern",
"pageid" : 2354,
"timestamp" : "2020-08-01T19:26:48Z",
"subspecialties" : "Surgery;Neurology",
"title" : "Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)",
"citation" : "ECST Writers. \"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)\". The Lancet. 1998. 351(9113):1379-1387.",
"pmid" : "9593407",
"pdfurl" : "",
"expansion" : "European Carotid Surgery Trial",
"published" : "1998-05-09",
"pageName" : "ECST",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2909292-1"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052187",
"pmid" : "16371630",
"citation" : "Nathan DM, et al. \"Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes\". The New England Journal of Medicine. 2005. 353(25):2643-2653.",
"title" : "Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052187",
"pageName" : "EDIC",
"expansion" : "Epidemiology of Diabetes Interventions and Complications",
"published" : "2005-12-22",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Intensive therapy associated with fewer cardiovascular complications",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Endocrinology",
"timestamp" : "2013-03-12T08:18:42Z",
"pageid" : 136,
"trainingLevel" : "intern",
"briefDesignDescription" : "Intensive glycemic therapy in T1DM",
"abbreviation" : "EDIC"
},
{
"pmid" : "28316279",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700518",
"title" : "Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism",
"citation" : "Weitz JI, et al. \"Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism\". The New England Journal of Medicine. 2017. 376(13):1211-22.",
"pageName" : "EINSTEIN CHOICE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700518",
"expansion" : "Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic Venous Thromboembolism",
"published" : "2017-03-30",
"briefResultsDescription" : "Rivaroxaban reduces recurrent VTE",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"statusUsableDate" : "2017-07-01",
"pageid" : 2927,
"timestamp" : "2017-12-03T22:35:08Z",
"subspecialties" : "Hematology",
"briefDesignDescription" : "Rivaroxaban after VTE treatment",
"abbreviation" : "EINSTEIN CHOICE",
"trainingLevel" : "Resident"
},
{
"briefResultsDescription" : "Rivaroxaban is noninferior to warfarin in PE treatment",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"statusUsableDate" : "2013-07-01",
"pageid" : 1519,
"timestamp" : "2017-12-03T22:35:09Z",
"subspecialties" : "Hematology;Pulmonology",
"abbreviation" : "EINSTEIN-PE",
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"trainingLevel" : "Student",
"pmid" : "22449293",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1113572",
"title" : "Oral rivaroxaban for the treatment of symptomatic pulmonary embolism",
"citation" : "Büller HR, et al. \"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism\". The New England Journal of Medicine. 2012. 366(14):1287-1297.",
"pageName" : "EINSTEIN-PE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1113572",
"expansion" : "",
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"citation" : "Ekberg H, et al. \"Reduced exposure to calcineurin inhibitors in renal transplantation\". The New England Journal of Medicine. 2007. 357(25):2562-2575.",
"title" : "Reduced exposure to calcineurin inhibitors in renal transplantation",
"pmid" : "18094377",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067411",
"expansion" : "Efficacy Limiting Toxicity Elimination-Symphony",
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"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067411",
"pageName" : "ELITE-Symphony",
"statusUsableDate" : "2015-02-01",
"briefResultsDescription" : "Daclizumab, mycophenolate, steroids, and tacrolimus beneficial",
"diseases" : "Kidney Transplant",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Immunosuppression after kidney transplant",
"abbreviation" : "ELITE-Symphony",
"subspecialties" : "Nephrology",
"pageid" : 2324,
"timestamp" : "2018-05-27T16:17:38Z"
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"pageName" : "EMBRACE",
"expansion" : "30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event",
"published" : "2014-06-26",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1311376",
"pmid" : "24963566",
"citation" : "Gladstone DJ, et al. \"Atrial Fibrillation in Patients with Cryptogenic Stroke\". The New England Journal of Medicine. 2014. 370(26):2467-2477.",
"title" : "Atrial Fibrillation in Patients with Cryptogenic Stroke",
"subspecialties" : "Neurology;Cardiology",
"timestamp" : "2018-09-13T17:28:08Z",
"pageid" : 2403,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Extended EKG monitoring after cryptogenic stroke",
"abbreviation" : "EMBRACE",
"diseases" : "Stroke;Atrial Fibrillation",
"briefResultsDescription" : "Extended EKG monitoring detects AF more frequently than 24-hour monitoring",
"statusUsableDate" : "2018-09-13"
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"subspecialties" : "Oncology",
"pageid" : 1257,
"timestamp" : "2021-07-28T13:09:44Z",
"trainingLevel" : "fellow",
"abbreviation" : "EMILIA",
"briefDesignDescription" : "T-DM1 in metastatic breast cancer",
"briefResultsDescription" : "T-DM1 prolongs PFS in metastatic breast cancer",
"diseases" : "Breast Cancer",
"statusUsableDate" : "2013-04-01",
"fulltexturl" : "http://www.nejm.org/doi/abs/10.1056/NEJMoa1209124",
"pageName" : "EMILIA",
"published" : "2012-11-08",
"expansion" : "Emtansine vs. Capecitabine+Lapatinib in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer",
"pmid" : "23020162",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1209124",
"citation" : "Verma S, et al. \"Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer\". The New England Journal of Medicine. 2012. 367(19):1783-1791.",
"title" : "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer"
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"published" : "2015-09-17",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1504720",
"pageName" : "EMPA-REG OUTCOME",
"citation" : "Zinman B, et al. \"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes\". The New England Journal of Medicine. 2015. 373(22):2117-28.",
"title" : "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",
"pmid" : "26378978",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1504720",
"trainingLevel" : "intern",
"abbreviation" : "EMPA-REG OUTCOME",
"briefDesignDescription" : "Empagliflozin for CV outcomes in T2DM",
"subspecialties" : "Cardiology;Endocrinology",
"pageid" : 2448,
"timestamp" : "2023-12-14T18:27:14Z",
"statusUsableDate" : "2015-10-01",
"briefResultsDescription" : "Empagliflozin reduces mortality compared to placebo in patients with type 2 diabetes",
"diseases" : "Diabetes Mellitus"
},
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"diseases" : "Heart Failure",
"briefResultsDescription" : "Empagliflozin improved outcomes in HFpEF",
"statusUsableDate" : "2021-09-09",
"subspecialties" : "Cardiology",
"timestamp" : "2022-10-13T18:59:03Z",
"pageid" : 4440,
"trainingLevel" : "Resident",
"abbreviation" : "EMPEROR-Preserved",
"briefDesignDescription" : "Empagliflozin in HFmrEF and HFpEF",
"pdfurl" : null,
"pmid" : "34449189",
"citation" : "Anker S, et al. \"Empagliflozin in Heart Failure with a Preserved Ejection Fraction\". New England Journal of Medicine. 2021. epub 2021-08-27:1-11.",
"title" : "Empagliflozin in Heart Failure with a Preserved Ejection Fraction",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2107038",
"pageName" : "EMPEROR-Preserved",
"expansion" : "Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction",
"published" : "2021-08-27"
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"trainingLevel" : "Resident",
"briefDesignDescription" : "Eplerenone in HFrEF",
"abbreviation" : "EMPHASIS-HF",
"subspecialties" : "Cardiology",
"pageid" : 120,
"timestamp" : "2017-12-03T22:35:16Z",
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Eplerenone reduces CV deaths and HF hospitalizations",
"diseases" : "Heart Failure",
"published" : "2011-01-06",
"expansion" : "Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009492",
"pageName" : "EMPHASIS-HF",
"citation" : "Zannad F, et al. \"Eplerenone in patients with systolic heart failure and mild symptoms\". The New England Journal of Medicine. 2011. 364(1):11-21.",
"title" : "Eplerenone in patients with systolic heart failure and mild symptoms",
"pmid" : "21073363",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009492"
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"published" : "2013-11-28",
"expansion" : "Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310907",
"pageName" : "ENGAGE AF-TIMI 48",
"citation" : "Guigliano RP, et al. \"Edoxaban versus warfarin in patients with atrial fibrillation\". The New England Journal of Medicine. 2013. 369(22):2093-2104.",
"title" : "Edoxaban versus warfarin in patients with atrial fibrillation",
"pmid" : "24251359",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310907",
"trainingLevel" : "resident",
"briefDesignDescription" : "Edoxaban vs. warfarin in AF",
"abbreviation" : "ENGAGE AF-TIMI 48",
"subspecialties" : "Cardiology",
"pageid" : 2471,
"timestamp" : "2024-10-03T18:39:58Z",
"statusUsableDate" : "2017-02-01",
"briefResultsDescription" : "Edoxaban is noninferior to warfarin to prevent stroke or thromboembolism",
"diseases" : "Atrial Fibrillation"
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"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1712746",
"pmid" : "29466159",
"title" : "Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty",
"citation" : "Anderson DR, et al. \"Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty\". The New England Journal of Medicine. 2018. 378(8):699-707.",
"pageName" : "EPCAT II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1712746",
"expansion" : "Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II",
"published" : "2018-02-22",
"diseases" : "Deep Vein Thrombosis;Hip Fracture;Meniscal Tear;Osteoarthritis;Pulmonary Embolism;Venous Thromboembolism",
"briefResultsDescription" : "Aspirin similar to rivaroxaban for prevention of VTE",
"statusUsableDate" : "2018-03-29",
"timestamp" : "2019-04-18T17:47:16Z",
"pageid" : 3552,
"subspecialties" : "Orthopedics;Hematology",
"briefDesignDescription" : "Aspirin vs. rivaroxaban for postoperative VTE prophylaxis",
"abbreviation" : "EPCAT II",
"trainingLevel" : "Resident"
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"subspecialties" : "Cardiology",
"pageid" : 16,
"timestamp" : "2015-12-24T15:08:03Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Eplerenone post-MI with HFrEF",
"abbreviation" : "EPHESUS",
"briefResultsDescription" : "Mortality benefit of eplerenone post MI with HFrEF",
"diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
"statusUsableDate" : "2012-03-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030207",
"pageName" : "EPHESUS",
"published" : "2003-04-03",
"expansion" : "Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study",
"pmid" : "12668699",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030207",
"citation" : "Pitt B, et al. \"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction\". The New England Journal of Medicine. 2003. 348(14):1309-21.",
"title" : "Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction"
},
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"briefResultsDescription" : "Edoxaban monotherapy has lower bleeding events in AF+stable CAD",
"diseases" : "Coronary Artery Disease;Atrial Fibrillation",
"statusUsableDate" : "2024-09-29",
"subspecialties" : "Cardiology",
"pageid" : 5576,
"timestamp" : "2024-10-03T19:17:59Z",
"trainingLevel" : "resident",
"abbreviation" : "EPIC-CAD",
"briefDesignDescription" : "Edoxaban±antiplatelet in AF+stable CAD",
"pmid" : "39225258",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2407362",
"citation" : "Choo MS, et al. \"Edoxaban antithrombotic therapy for atrial fibrillation and stable coronary artery disease\". The New England Journal of Medicine. 2024. 1-13.",
"title" : "Edoxaban antithrombotic therapy for atrial fibrillation and stable coronary artery disease",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2407362",
"pageName" : "EPIC-CAD",
"published" : "2024-09-01",
"expansion" : "Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease"
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"diseases" : "Prostate Cancer",
"briefResultsDescription" : "Decrease in prostate cancer mortality but increased risk of overdiagnosis and overtreatment",
"statusUsableDate" : "2016-07-01",
"timestamp" : "2017-12-03T22:35:20Z",
"pageid" : 2796,
"subspecialties" : "Urology;Oncology;Preventive Medicine",
"briefDesignDescription" : "PSA for prostate cancer screening",
"abbreviation" : "ERSPC",
"trainingLevel" : "Intern",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810084",
"pmid" : "19297566",
"title" : "Screening and Prostate-Cancer Mortality in a Randomized European Study",
"citation" : "Schröder FH, et al. \"Screening and Prostate-Cancer Mortality in a Randomized European Study\". The New England Journal of Medicine. 2009. 360(13):1320-1328.",
"pageName" : "ERSPC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810084",
"published" : "2009-07-09",
"expansion" : "European Randomized Study of Screening for Prostate Cancer"
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"statusUsableDate" : "2013-06-01",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Routine PA catheters no better than clinical assessment",
"briefDesignDescription" : "PA catheters in acute HF management",
"abbreviation" : "ESCAPE",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:35:21Z",
"pageid" : 1407,
"subspecialties" : "Cardiology;Critical Care",
"title" : "Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness",
"citation" : "Binanay C, et al. \"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness\". JAMA. 2005. 294(13):1625-1633.",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4994/JOC50108.pdf",
"pmid" : "16204662",
"expansion" : "Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness",
"published" : "2005-10-05",
"pageName" : "ESCAPE",
"fulltexturl" : null
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"abbreviation" : "ESPRIT",
"briefDesignDescription" : "ASA+dipyridamole in secondary stroke prevention",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:35:22Z",
"pageid" : 1726,
"subspecialties" : "Neurology",
"statusUsableDate" : "2013-11-01",
"diseases" : "Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "ASA+dipyridamole better than ASA for secondary stroke prevention",
"expansion" : "European/Australasian Stroke Prevention in Reversible Ischaemia Trial",
"published" : "2006-05-20",
"pageName" : "ESPRIT",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2806%2968734-5/fulltext",
"title" : "Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial",
"citation" : "Halkes PH, et al. \"Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial\". The Lancet. 2006. 367(9523):1665-1673.",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606687345.pdf",
"pmid" : "16714187"
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"pmid" : "9250846",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199708143370702",
"title" : "A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease",
"citation" : "Cohen M, et al. \"A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease\". The New England Journal of Medicine. 1997. 337(7):447-452.",
"pageName" : "ESSENCE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199708143370702",
"published" : "1997-08-14",
"expansion" : "Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group",
"briefResultsDescription" : "LMWH reduces 14-day mortality, MI, or recurrent angina in UA/NSTEMI",
"diseases" : "Acute Coronary Syndrome",
"statusUsableDate" : "2013-05-01",
"pageid" : 1443,
"timestamp" : "2017-12-03T22:35:24Z",
"subspecialties" : "Cardiology",
"abbreviation" : "ESSENCE",
"briefDesignDescription" : "LMWH vs. UFH in UA/NSTEMI",
"trainingLevel" : "Intern"
},
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"title" : "Ticagrelor versus clopidogrel in symptomatic peripheral artery disease",
"citation" : "Hiatt WR et al. \"Ticagrelor versus clopidogrel in symptomatic peripheral artery disease\". New Engl J Med. 2017. 376(1):32-40.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611688",
"pmid" : "27959717",
"published" : "2017-01-05",
"expansion" : "Examining use of ticagrelor in peripheral artery disease",
"pageName" : "EUCLID (Ticagrelor)",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611688",
"statusUsableDate" : "2017-01-01",
"diseases" : "Peripheral Vascular Disease",
"briefResultsDescription" : "Ticagrelor not superior to clopidogrel in symptomatic PAD",
"briefDesignDescription" : "Ticagrelor vs. clopidogrel in symptomatic PAD",
"abbreviation" : "EUCLID",
"trainingLevel" : "Resident",
"timestamp" : "2021-01-25T01:47:56Z",
"pageid" : 2878,
"subspecialties" : "Cardiology"
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"pmid" : "13678872",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14286-9.pdf",
"citation" : "Fox KM, et al. \"Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease\". The Lancet. 2003. 362(9386):782–788.",
"title" : "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14286-9/fulltext",
"pageName" : "EUROPA",
"published" : "2003-09-06",
"expansion" : "European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease",
"briefResultsDescription" : "Perindopril reduces composite of CV mortality, MI, or cardiac arrest",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2018-02-08",
"subspecialties" : "Cardiology",
"pageid" : 2823,
"timestamp" : "2018-02-08T17:32:01Z",
"trainingLevel" : "intern",
"briefDesignDescription" : "Perindopril in patients with stable CAD",
"abbreviation" : "EUROPA"
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"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021334",
"pageName" : "European Dexamethasone Study",
"published" : "2002-11-14",
"expansion" : "European Dexamethasone Study",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021334",
"pmid" : "12432041",
"citation" : "de Gans JD, et al. \"Dexamethasone in Adults with Bacterial Meningitis\". The New England Journal of Medicine. 2002. 347(20):1549-1556.",
"title" : "Dexamethasone in Adults with Bacterial Meningitis",
"subspecialties" : "Infectious Disease;Neurology",
"timestamp" : "2017-12-03T22:35:34Z",
"pageid" : 306,
"trainingLevel" : "Resident",
"abbreviation" : "EDS",
"briefDesignDescription" : "Dexamethasone in meningitis",
"diseases" : "Meningitis",
"briefResultsDescription" : "Dexamethasone reduces mortality in bacterial meningitis",
"statusUsableDate" : "2012-04-01"
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"citation" : "Konstam MA, et al. \"The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure\". The Journal of the American Medical Association. 2007. 297(12):1319-1331.",
"title" : "The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5131/joc70029_1319_1331.pdf",
"pmid" : "17384437",
"expansion" : "Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan",
"published" : "2007-03-28",
"fulltexturl" : null,
"pageName" : "EVEREST-Outcomes",
"statusUsableDate" : "2013-06-01",
"diseases" : "Heart Failure",
"briefResultsDescription" : "No benefit from tolvaptan when given for 60 days after acute HF episode",
"trainingLevel" : "Resident",
"abbreviation" : "EVEREST",
"briefDesignDescription" : "Tolvaptan in acute HF in HFrEF",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:35:27Z",
"pageid" : 1345
},
{
"citation" : "Popma JJ, et al. \"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients\". The New England Journal of Medicine. 2019. 380(18):1706-1715.",
"title" : "Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1816885",
"pmid" : "30883053",
"expansion" : "",
"published" : "2019-05-02",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1816885",
"pageName" : "Evolut Low Risk",
"statusUsableDate" : "2024-06-27",
"diseases" : "Aortic Stenosis",
"briefResultsDescription" : "TAVR non-inferior to surgery at 24 months in low-risk patients",
"trainingLevel" : "resident",
"abbreviation" : "",
"briefDesignDescription" : "TAVR in low-risk patients",
"subspecialties" : "Cardiology",
"timestamp" : "2024-06-27T19:03:26Z",
"pageid" : 4061
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"expansion" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
"published" : "2012-12-27",
"pageName" : "EVOLVE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205624",
"title" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
"citation" : "Chertow GM, et al. \"Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis\". The New England Journal of Medicine. 2012. 367(26):2482-2494.",
"pmid" : "23121374",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205624",
"briefDesignDescription" : "Cinacalcet in ESRD",
"abbreviation" : "EVOLVE",
"trainingLevel" : "Resident",
"pageid" : 2426,
"timestamp" : "2017-12-03T22:35:28Z",
"subspecialties" : "Nephrology",
"statusUsableDate" : "2015-10-01",
"briefResultsDescription" : "Cinecalcet did not reduce CV events in ESRD",
"diseases" : "Chronic Kidney Disease;Cardiovascular Disease"
},
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"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "PCI noninferior to CABG in left main CAD with low-intermediate anatomic complexity",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "EXCEL",
"briefDesignDescription" : "CABG vs. PCI in left main CAD",
"trainingLevel" : "Resident",
"pageid" : 2868,
"timestamp" : "2017-12-03T22:35:29Z",
"subspecialties" : "Cardiology",
"title" : "Everolimus-eluting stents or bypass surgery for left main coronary artery disease",
"citation" : "Stone GW, et al. \"Everolimus-eluting stents or bypass surgery for left main coronary artery disease\". The New England Journal of Medicine. 2016. 375(23):2223-35.",
"pmid" : "27797291",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1610227",
"expansion" : "XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL)",
"published" : "2016-12-08",
"pageName" : "EXCEL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1610227"
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"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Omalizumab reduces asthma exacerbations",
"diseases" : "Asthma",
"trainingLevel" : "Fellow",
"abbreviation" : "EXTRA",
"briefDesignDescription" : "Omalizumab in severe allergic asthma",
"subspecialties" : "Allergy and Immunology;Pulmonology;Pediatrics",
"pageid" : 1434,
"timestamp" : "2017-12-03T22:35:31Z",
"citation" : "Hanania NA, et al. \"Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial\". Annals of Internal Medicine. 2011. 154(9):573-582.",
"title" : "Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial",
"pmid" : "21536936",
"pdfurl" : "http://annals.org/data/Journals/AIM/20231/0000605-201105030-00002.pdf",
"published" : "2011-05-03",
"expansion" : "A Study of Omalizumab/Xolair in Subjects With Moderate to Severe Persistent Asthma",
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"published" : "2006-06-15",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa062200",
"pageName" : "FACTT",
"citation" : "Wiedemann HP, et al. \"Comparison of two fluid-management strategies in acute lung injury\". The New England Journal of Medicine. 2006. 354(24):2564-75.",
"title" : "Comparison of two fluid-management strategies in acute lung injury",
"pmid" : "16714767",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa062200",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Fluid management in ARDS",
"abbreviation" : "FACTT",
"subspecialties" : "Critical Care",
"pageid" : 24,
"timestamp" : "2015-11-07T23:16:22Z",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit of conservative fluid management in ALI/ARDS",
"diseases" : "Acute Respiratory Distress Syndrome"
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"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa0908355",
"pmid" : "19920054",
"citation" : "Anker SD, et al. \"Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency\". The New England Journal of Medicine. 2009. 361(25):2436-48.",
"title" : "Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa0908355",
"pageName" : "FAIR-HF",
"expansion" : "IV Iron for Symptoms in Patients with HFrEF and Iron Deficiency",
"published" : "2009-12-17",
"diseases" : "Heart Failure;Iron Deficiency Anemia",
"briefResultsDescription" : "IV iron improves HFrEF symptoms in patients with HFrEF and iron deficiency",
"statusUsableDate" : "2019-03-01",
"subspecialties" : "Cardiology;Hematology",
"timestamp" : "2019-02-28T18:37:32Z",
"pageid" : 2691,
"trainingLevel" : "Intern",
"abbreviation" : "FAIR-HF",
"briefDesignDescription" : "Parenteral iron in HFrEF with iron deficiency"
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"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2012-10-01",
"subspecialties" : "Cardiology",
"pageid" : 998,
"timestamp" : "2018-01-03T20:13:15Z",
"trainingLevel" : "resident",
"abbreviation" : "FAME",
"briefDesignDescription" : "FFR-guided PCI in stable CAD",
"pmid" : "19144937",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807611",
"citation" : "Tonino PAL, et al. \"Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention\". The New England Journal of Medicine. 2009. 360(3):213-224.",
"title" : "Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807611",
"pageName" : "FAME",
"published" : "2009-01-15",
"expansion" : "Fractional Flow Reserve versus Angiography for Multivessel Evaluation"
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"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205361",
"pmid" : "22924638",
"title" : "Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease",
"citation" : "De Bruyne B, et al. \"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease\". The New England Journal of Medicine. 2012. 367(11):991-1001.",
"pageName" : "FAME 2",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205361",
"published" : "2012-09-13",
"expansion" : "FFR vs. Angiographyfor Multivessel Evaluation 2",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "FFR-guided PCI reduces urgent revascularization",
"statusUsableDate" : "2012-11-01",
"timestamp" : "2018-07-05T13:05:28Z",
"pageid" : 1003,
"subspecialties" : "Cardiology",
"abbreviation" : "FAME 2",
"briefDesignDescription" : "FFR-guided PCI vs. OMT in CAD",
"trainingLevel" : "Resident"
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"title" : "Mortality after fluid bolus in African children with severe infection",
"citation" : "Maitland K, et al. \"Mortality after fluid bolus in African children with severe infection\". The New England Journal of Medicine. 2011. 364(26):2483-2495.",
"pmid" : "21615299",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1101549",
"expansion" : "Fluid Expansion as Supportive Therapy",
"published" : "2011-06-30",
"pageName" : "FEAST",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1101549",
"statusUsableDate" : "2014-11-01",
"briefResultsDescription" : "Albumin and saline increase mortality when compared to no fluids in this patient population",
"diseases" : "Shock",
"abbreviation" : "FEAST",
"briefDesignDescription" : "Fluid resuscitation in Sub-Saharan Africa",
"trainingLevel" : "Resident",
"pageid" : 1860,
"timestamp" : "2017-12-03T22:35:38Z",
"subspecialties" : "Pediatrics;Critical Care"
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"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910812",
"pmid" : "21288078",
"citation" : "Louie TJ, et al. \"Fidaxomicin versus Vancomycin for Clostridium difficile Infection\". The New England Journal of Medicine. 2011. 365(5):422-431.",
"title" : "Fidaxomicin versus Vancomycin for Clostridium difficile Infection",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910812",
"pageName" : "Fidaxomicin in C. difficile Diarrhea",
"expansion" : null,
"published" : "2011-02-03",
"diseases" : "Clostridium difficile",
"briefResultsDescription" : "Fidaxomicin noninferior to vancomycin for cure, and resulted in 45% fewer recurrences",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Infectious Disease;Gastroenterology",
"timestamp" : "2013-10-07T20:50:13Z",
"pageid" : 255,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Fidaxomicin in C. difficile",
"abbreviation" : null
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"pmid" : "33264825",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2025845",
"citation" : "Bakris GL, et al. \"Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes\". The New England Journal of Medicine. 2020. 383(23):2219-2229.",
"title" : "Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2025845",
"pageName" : "FIDELIO-DKD",
"expansion" : "Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease",
"published" : "2020-10-23",
"briefResultsDescription" : "Mineralocorticoid antagonist slows CKD progression",
"diseases" : "Chronic Kidney Disease;Diabetes Mellitus",
"statusUsableDate" : "2024-10-17",
"subspecialties" : "Nephrology;Endocrinology",
"pageid" : 4384,
"timestamp" : "2024-10-17T17:57:15Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Mineralocorticoid antagonist in CKD/T2DM",
"abbreviation" : "FIDELIO-DKD"
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"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200105033441801",
"pmid" : "11333990",
"citation" : "Tuomilehto J, et al. \"Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance\". The New England Journal of Medicine. 2001. 344(18):1343-1350.",
"title" : "Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200105033441801#t",
"pageName" : "Finnish Diabetes Prevention Study",
"published" : "2001-15-03",
"expansion" : "",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Intensive lifestyle interventions prevent diabetes",
"statusUsableDate" : "2025-06-01",
"subspecialties" : "Endocrinology",
"timestamp" : "2025-06-05T17:26:20Z",
"pageid" : 2776,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Lifestyle interventions to prevent diabetes",
"abbreviation" : "Finnish Diabetes Prevention Study"
},
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"statusUsableDate" : "2016-07-01",
"diseases" : "Atrial Fibrillation",
"briefResultsDescription" : "Cryoablation equivalent to RF ablation in pAF",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Cryoablation vs. RF ablation in pAF",
"abbreviation" : "FIRE AND ICE",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:35:39Z",
"pageid" : 2795,
"citation" : "Kuck K, et al. \"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation\". The New England Journal of Medicine. 2016. 374(23):2235-45.",
"title" : "Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602014",
"pmid" : "27042964",
"expansion" : "",
"published" : "2016-06-09",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602014",
"pageName" : "FIRE AND ICE"
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"pmid" : "27181606",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1516385",
"citation" : "Wedzicha JA, et al. \"Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD\". The New England Journal of Medicine. 2016. 374(23):2222-2234.",
"title" : "Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1516385",
"pageName" : "FLAME (COPD)",
"expansion" : "Effect of Indacaterol Glycopyronium Vs. Fluticasone Salmeterol on COPD Exacerbations",
"published" : "2016-06-09",
"briefResultsDescription" : "LABA+LAMA reduces COPD exacerbations",
"diseases" : "Emphysema;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease",
"statusUsableDate" : "2017-01-01",
"subspecialties" : "Pulmonology",
"pageid" : 2871,
"timestamp" : "2017-12-03T22:35:41Z",
"trainingLevel" : "Resident",
"abbreviation" : "FLAME COPD",
"briefDesignDescription" : "LABA+LAMA vs. LABA+ICS in COPD"
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"briefResultsDescription" : "Early fluoxetine improved motor outcomes post stroke",
"diseases" : "Stroke",
"statusUsableDate" : "2015-08-01",
"subspecialties" : "Neurology",
"pageid" : 2370,
"timestamp" : "2018-10-08T21:47:35Z",
"trainingLevel" : "Resident",
"abbreviation" : "FLAME",
"briefDesignDescription" : "SSRI after CVA for motor recovery",
"pmid" : "21216670",
"pdfurl" : "",
"citation" : "Chollet F, et al. \"Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial\". The Lancet Neurology. 2011. 10(2):123-130.",
"title" : "Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S1474-4422(10)70314-8",
"pageName" : "FLAME (Stroke)",
"published" : "2011-02-01",
"expansion" : "Fluoxetine for Motor Recovery after Acute Ischaemic Stroke"
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"abbreviation" : "FLORALI",
"briefDesignDescription" : "High-flow oxygen in respiratory failure",
"trainingLevel" : "Intern",
"timestamp" : "2025-06-19T18:32:02Z",
"pageid" : 2375,
"subspecialties" : "Pulmonology;Critical Care",
"statusUsableDate" : "2012-03-01",
"diseases" : "Respiratory Failure",
"briefResultsDescription" : "High-flow oxygen therapy reduces intubation need",
"expansion" : "",
"published" : "2015-06-04",
"pageName" : "FLORALI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1503326",
"title" : "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure",
"citation" : "Frat JP, et al. \"High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure\". The New England Journal of Medicine. 2015. 372(23):2185-2196.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1503326",
"pmid" : "25981908"
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"statusUsableDate" : "2017-12-14",
"diseases" : "Hip Fracture;Anemia",
"briefResultsDescription" : "Liberal transfusions no better than restrictive",
"trainingLevel" : "Resident",
"abbreviation" : "FOCUS",
"briefDesignDescription" : "Transfusion thresholds after hip surgery",
"subspecialties" : "Hematology;Surgery",
"timestamp" : "2017-12-14T18:13:26Z",
"pageid" : 2985,
"citation" : "Carson JL, et al. \"Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery\". The New england Journal of Medicine. 2011. 365(26):2453-62.",
"title" : "Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1012452",
"pmid" : "22168590",
"expansion" : "Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair",
"published" : "2011-12-29",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1012452",
"pageName" : "FOCUS"
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"statusUsableDate" : "2017-03-01",
"briefResultsDescription" : "Evolocumab reduces CV events in patients with atherosclerotic disease",
"diseases" : "Coronary Artery Disease",
"abbreviation" : "FOURIER",
"briefDesignDescription" : "Evolocumab for CVD events if atherosclerotic disease",
"trainingLevel" : "Resident",
"pageid" : 2891,
"timestamp" : "2020-11-05T18:42:16Z",
"subspecialties" : "Cardiology",
"title" : "Evolocumab and clinical outcomes in patients with cardiovascular disease",
"citation" : "Sabatine MS, et al. \"Evolocumab and clinical outcomes in patients with cardiovascular disease\". The New England Journal of Medicine. 2017. epub 2017-03-17:1-10.",
"pmid" : "28304224",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1615664",
"expansion" : "Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk",
"published" : "2017-03-17",
"pageName" : "FOURIER",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1615664"
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"briefResultsDescription" : "CABG reduces death and revascularization rates but causes more strokes",
"diseases" : "Coronary Artery Disease;Diabetes Mellitus",
"statusUsableDate" : "2016-04-01",
"pageid" : 2314,
"timestamp" : "2017-12-03T22:35:45Z",
"subspecialties" : "Cardiology;Endocrinology",
"briefDesignDescription" : "CABG vs. PCI for CAD in T2DM",
"abbreviation" : "FREEDOM",
"trainingLevel" : "Resident",
"pmid" : "23121323",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211585",
"title" : "Strategies for multivessel revascularization in patients with diabetes",
"citation" : "Farkouh ME, et al. \"Strategies for multivessel revascularization in patients with diabetes\". The New England Journal of Medicine. 2012. 367(25):2375-2384.",
"pageName" : "FREEDOM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211585",
"expansion" : "Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease",
"published" : "2012-12-20"
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"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07349-3/fulltext",
"pageName" : "FRISC-II",
"published" : "1999-08-28",
"expansion" : "FRagmin and Fast Revascularisation during InStability in Coronary artery disease-II",
"pmid" : "10475181",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(99)07349-3.pdf",
"citation" : "FRISC Investigators. \"Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study\". The Lancet. 1999. 354(9180):708-15.",
"title" : "Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study",
"subspecialties" : "Cardiology",
"pageid" : 2451,
"timestamp" : "2021-06-01T13:47:49Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Early invasive strategy in UA/NSTEMI",
"abbreviation" : "FRISC-II",
"briefResultsDescription" : "Fewer recurrent MIs with early invasive strategy in high-risk patients",
"diseases" : "Coronary Artery Disease;Myocardial Infarction;Acute Coronary Syndrome",
"statusUsableDate" : "2015-11-01"
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"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Greatest risk for GI bleed with coagulopathy and mechanical ventilation",
"diseases" : "Gastrointestinal Hemorrhage",
"briefDesignDescription" : "Risk factors for GI bleeds in ICU patients",
"abbreviation" : null,
"trainingLevel" : "Intern",
"pageid" : 391,
"timestamp" : "2017-12-03T22:35:49Z",
"subspecialties" : "Critical Care;Gastroenterology",
"title" : "Risk factors for gastrointestinal bleeding in critically ill patients",
"citation" : "Cook DJ, et al. \"Risk factors for gastrointestinal bleeding in critically ill patients\". The New England Journal of Medicine. 1994. 330(6):337-381.",
"pmid" : "8284001",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199402103300601",
"published" : "1994-02-10",
"expansion" : null,
"pageName" : "GI bleeding in ICU patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199402103300601"
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"pageName" : "GISSI-3",
"expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico",
"published" : "1994-05-07",
"pdfurl" : "",
"pmid" : "7910229",
"citation" : "GISSI-3 Group. \"Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction\". The Lancet. 1994. 343(8906):1115-22.",
"title" : "Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction",
"subspecialties" : "Cardiology",
"timestamp" : "2014-09-24T22:28:37Z",
"pageid" : 258,
"trainingLevel" : "Resident",
"abbreviation" : "GISSI-3",
"briefDesignDescription" : "Lisinopril in acute MI",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"briefResultsDescription" : "Lisinopril improves 6-week mortality",
"statusUsableDate" : "2012-03-01"
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"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)61239-8.pdf",
"pmid" : "18757090",
"citation" : "Tavazzi L, et al. \"Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure\". The Lancet. 2008. 372(9645):1223-1230.",
"title" : "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61239-8/fulltext",
"pageName" : "GISSI-HF",
"expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione",
"published" : "2008-10-04",
"diseases" : "Heart Failure",
"briefResultsDescription" : "PUFA reduces all-cause mortality and admission for CV disease",
"statusUsableDate" : "2023-07-31",
"subspecialties" : "Cardiology",
"timestamp" : "2025-05-22T17:32:19Z",
"pageid" : 2824,
"trainingLevel" : "intern",
"briefDesignDescription" : "PUFA in patients with heart failure",
"abbreviation" : "GISSI-HF"
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"statusUsableDate" : "2014-09-01",
"diseases" : "Myocardial Infarction;Acute Coronary Syndrome",
"briefResultsDescription" : "tPA reduces mortality in ACS",
"trainingLevel" : "Student",
"briefDesignDescription" : "tPA in ACS",
"abbreviation" : "GUSTO",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:35:51Z",
"pageid" : 2177,
"citation" : "Topol E, et al. \"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction\". The New England Journal of Medicine. 1993. 329(10):673-682.",
"title" : "An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309023291001",
"pmid" : "8204123",
"published" : "1993-09-03",
"expansion" : "Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309023291001",
"pageName" : "GUSTO"
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"briefResultsDescription" : "Hypothermia improves neurologic outcomes and reduces mortality",
"diseases" : "Cardiac Arrest",
"statusUsableDate" : "2012-03-01",
"pageid" : 410,
"timestamp" : "2024-08-25T20:47:09Z",
"subspecialties" : "Critical Care;Neurology;Cardiology",
"briefDesignDescription" : "Hypothermia for cardiac arrest",
"abbreviation" : "HACA",
"trainingLevel" : "Resident",
"pmid" : "11856793",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa012689",
"title" : "Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest",
"citation" : "Holzer M, et al. \"Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest\". The New England Journal of Medicine. 2002. 346(8):549-556.",
"pageName" : "HACA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/nejmoa012689",
"expansion" : "Hypothermia After Cardiac Arrest",
"published" : "2002-02-21"
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"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61913-9/fulltext",
"pageName" : "HEAAL",
"expansion" : "Heart failure Endpoint evaluation of Angiotensin II Antagonist Losartan",
"published" : "2009-11-28",
"pmid" : "19922995",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(09)61913-9.pdf",
"citation" : "Konstam MA, et al. \"Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure\". The Lancet. 2009. 374(9704):1840-1848.",
"title" : "Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure",
"subspecialties" : "Cardiology",
"pageid" : 2825,
"timestamp" : "2025-05-22T17:34:50Z",
"trainingLevel" : "resident",
"abbreviation" : "HEAAL",
"briefDesignDescription" : "High- vs. low-dose losartan in heart failure",
"briefResultsDescription" : "High-dose losartan improves HF outcomes",
"diseases" : "Heart Failure",
"statusUsableDate" : "2025-05-12"
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"diseases" : "Heart Failure",
"briefResultsDescription" : "Continuous-flow LVAD improved survival free from stroke and device failure",
"statusUsableDate" : "2016-09-01",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:35:53Z",
"pageid" : 2808,
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Continuous-flow LVAD in heart failure",
"abbreviation" : "HEARTMATE II",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909938",
"pmid" : "19920051",
"citation" : "Slaughter MS, et al. \"Advanced heart failure treated with continuous-flow left ventricular assist device\". The New England Journal of Medicine. 2009. 361(23):2241-2251.",
"title" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909938#t",
"pageName" : "HEARTMATE II",
"expansion" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
"published" : "2009-12-03"
},
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"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1508375",
"pmid" : "26436473",
"title" : "Acetaminophen for Fever in Critically Ill Patients with Suspected Infection",
"citation" : "Young P, et al. \"Acetaminophen for Fever in Critically Ill Patients with Suspected Infection\". The New England Journal of Medicine. 2015. 373(23):2215-2224.",
"pageName" : "HEAT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1508375",
"published" : "2015-12-03",
"expansion" : "Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit",
"diseases" : "Sepsis;Fever",
"briefResultsDescription" : "Acetaminophen does not improves ICU outcomes",
"statusUsableDate" : "2017-09-01",
"timestamp" : "2020-11-04T18:25:05Z",
"pageid" : 2690,
"subspecialties" : "Critical Care;Infectious Disease",
"abbreviation" : "HEAT",
"briefDesignDescription" : "Acetaminophen in febrile ICU patients",
"trainingLevel" : "Intern"
},
{
"statusUsableDate" : "2023-01-29",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Heparin better than bivalirudin for PCI",
"trainingLevel" : "Resident",
"abbreviation" : "HEAT-PPCI",
"briefDesignDescription" : "Heparin vs. bivalirudin in PCI",
"subspecialties" : "Cardiology",
"timestamp" : "2023-02-02T19:36:38Z",
"pageid" : 2394,
"citation" : "Shahzad A, et al. \"Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.\". The Lancet. 2014. 384(9957):1849-1858.",
"title" : "Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.",
"pdfurl" : "",
"pmid" : "25002178",
"published" : "2014-11-22",
"expansion" : "",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60924-7",
"pageName" : "HEAT-PPCI"
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"published" : "2002-12-19",
"expansion" : "Hemodialysis",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021583",
"pageName" : "HEMO",
"citation" : "Rose EA, et al. \"Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis\". The New England Journal of Medicine. 2002. 347(25):2020-2019.",
"title" : "Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis",
"pmid" : "12490682",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021583",
"trainingLevel" : "Fellow",
"abbreviation" : "HEMO",
"briefDesignDescription" : "High dialysis dose and high-flux membrane in hemodialysis",
"subspecialties" : "Nephrology",
"pageid" : 2771,
"timestamp" : "2018-10-25T17:06:10Z",
"statusUsableDate" : "2018-03-15",
"briefResultsDescription" : "High dialysis dose and high-flux membrane did not reduce all-cause mortality",
"diseases" : "Chronic Kidney Disease"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052306",
"pageName" : "HERA",
"published" : "2005-10-20",
"expansion" : "Herceptin Adjuvant Trial",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052306",
"pmid" : "16236737",
"citation" : "Piccart-Gebhart MJ, et al. \"Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer\". The New England Journal of Medicine. 2005. 353(16):1659-72.",
"title" : "Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer",
"subspecialties" : "Oncology",
"timestamp" : "2013-10-09T17:11:02Z",
"pageid" : 440,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Trastuzumab in breast cancer",
"abbreviation" : "HERA",
"diseases" : "Breast Cancer",
"briefResultsDescription" : "Trastuzumab improves survival",
"statusUsableDate" : "2012-03-01"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711948",
"pmid" : "29231094",
"title" : "Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism",
"citation" : "Raskob GE, et al. \"Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism\". The New England Journal of Medicine. 2018. 378(7):615-624.",
"pageName" : "Hokusai-VTE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711948",
"expansion" : "",
"published" : "2018-02-15",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"briefResultsDescription" : "Edoxaban noninferior to dalteparin in cancer VTE",
"statusUsableDate" : "2018-02-01",
"timestamp" : "2020-10-29T17:37:34Z",
"pageid" : 3509,
"subspecialties" : "Hematology;Oncology",
"briefDesignDescription" : "Edoxaban vs. LMWH in cancer VTE",
"abbreviation" : "",
"trainingLevel" : "Resident"
},
{
"statusUsableDate" : "2012-03-01",
"diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "Ramipril reduces death, MI, and stroke",
"briefDesignDescription" : "Ramipril in patients with high CV risk",
"abbreviation" : "HOPE",
"trainingLevel" : "intern",
"timestamp" : "2013-08-15T18:50:04Z",
"pageid" : 1165,
"subspecialties" : "Cardiology;Neurology",
"title" : "Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients",
"citation" : "Yusuf S, et al. \"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients\". The New England Journal of Medicine. 2000. 342(3):145-153.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200001203420301",
"pmid" : "10639539",
"published" : "2000-01-20",
"expansion" : "Heart Outcomes Prevention Evaluation",
"pageName" : "HOPE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200001203420301"
},
{
"statusUsableDate" : "2020-12-10",
"diseases" : "Sickle Cell Disease",
"briefResultsDescription" : "Voxelotor increases hemoglobin and reduces evidence of hemolysis",
"briefDesignDescription" : "Voxelotor in sickle cell disease",
"abbreviation" : "HOPE",
"trainingLevel" : "resident",
"timestamp" : "2020-12-31T20:42:03Z",
"pageid" : 4382,
"subspecialties" : "Hematology",
"title" : "A phase 3 randomized trial of voxelotor in sickle cell disease",
"citation" : "Vichinsky E, et al. \"A phase 3 randomized trial of voxelotor in sickle cell disease\". The New England Journal of Medicine. 2019. 381(8):509-519.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903212",
"pmid" : "31199090",
"expansion" : "Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization",
"published" : "2019-08-08",
"pageName" : "HOPE (Sickle Cell Disease)",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa1903212"
},
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"trainingLevel" : "Resident",
"abbreviation" : "HOPE-3",
"briefDesignDescription" : "Statin, BP meds, both, or neither for CVD 1° prevention",
"subspecialties" : "Cardiology",
"timestamp" : "2019-09-20T14:01:16Z",
"pageid" : 2770,
"statusUsableDate" : "2019-09-19",
"diseases" : "Cardiovascular Disease",
"briefResultsDescription" : "Statins lower events but BP meds don't.",
"expansion" : "Heart Outcomes Prevention Evaluation-3",
"published" : "2016-05-26",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1600177",
"pageName" : "HOPE-3",
"citation" : "Yusuf S, et al. \"Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease\". The New England Journal of Medicine. 2016. 374(21):2032-2343.",
"title" : "Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1600177",
"pmid" : "27039945"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Zoledronate vs. placebo in osteoporosis",
"abbreviation" : "HORIZON-PFT",
"subspecialties" : "Endocrinology;Preventive Medicine",
"timestamp" : "2021-09-09T17:34:24Z",
"pageid" : 2765,
"statusUsableDate" : "2021-08-31",
"diseases" : "Osteoporosis",
"briefResultsDescription" : "Annual zoledronate reduces fracture risk in osteoporosis",
"expansion" : "Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial",
"published" : "2007-05-03",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa067312",
"pageName" : "HORIZON-PFT",
"citation" : "Black DM, et al. \"Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis\". The New England Journal of Medicine. 2007. 356(18):1809-22.",
"title" : "Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa067312",
"pmid" : "17476007"
},
{
"trainingLevel" : "Fellow",
"abbreviation" : null,
"briefDesignDescription" : "Duration of empiric antibiotics in ↑risk neutropenic fever",
"subspecialties" : "Infectious Disease;Hematology",
"pageid" : 4119,
"timestamp" : "2024-05-02T17:49:17Z",
"statusUsableDate" : "2021-03-15",
"briefResultsDescription" : "Shorter courses of antibiotics led to fewer days of antibiotics without excess harm",
"diseases" : "Febrile Neutropenia",
"expansion" : null,
"published" : "2017-11-15",
"fulltexturl" : "https://doi.org/10.1016/S2352-3026(17)30211-9",
"pageName" : "How Long",
"citation" : "Aguilar-Guisado M, et al. \"Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial\". Lancet Haematology. 2017. 4(12):e573-e583.",
"title" : "Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial",
"pmid" : "29153975",
"pdfurl" : null
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"published" : "2002-06-06",
"expansion" : "Heart Protection Study Statin Arm",
"pageName" : "HPS Statin",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(02)09327-3",
"title" : "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial",
"citation" : "Heart Protection Study Collaborative Group Writers. \"MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial\". The Lancet. 2002. 360(9326):7-22.",
"pdfurl" : "",
"pmid" : "12114036",
"abbreviation" : "HPS",
"briefDesignDescription" : "Simvastatin in high risk for CVD",
"trainingLevel" : "Student",
"timestamp" : "2020-02-06T19:36:49Z",
"pageid" : 2696,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2020-02-07",
"diseases" : "Hyperlipidemia;Cardiovascular Disease",
"briefResultsDescription" : "Simvastatin reduces CVD events and death"
},
{
"pageid" : 2329,
"timestamp" : "2017-12-03T22:35:56Z",
"subspecialties" : "Cardiology",
"abbreviation" : "HPS2-THRIVE",
"briefDesignDescription" : "Niacin in atherosclerotic disease",
"trainingLevel" : "Intern",
"briefResultsDescription" : "Niacin is poorly tolerated, doesn't reduce major vascular events",
"diseases" : "Coronary Artery Disease;Peripheral Vascular Disease",
"statusUsableDate" : "2015-02-01",
"pageName" : "HPS2-THRIVE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300955",
"published" : "2014-07-17",
"expansion" : "Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events",
"pmid" : "25014686",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300955",
"title" : "Effects of extended-release niacin with laropiprant in high-risk patients",
"citation" : "Landray MJ et al. \"Effects of extended-release niacin with laropiprant in high-risk patients\". The New England Journal of Medicine. 2014. 371(3):203-212."
},
{
"pmid" : "21767103",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1105243",
"citation" : "Cohen MS, et al. \"Prevention of HIV-1 Infection with Early Antiretroviral Therapy\". The New England Journal of Medicine. 2011. 365(6):493-505.",
"title" : "Prevention of HIV-1 Infection with Early Antiretroviral Therapy",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1105243",
"pageName" : "HPTN 052",
"published" : "2011-08-11",
"expansion" : "HIV Prevention Trials Network 052 Study",
"briefResultsDescription" : "Reduced morbidity and HIV transmission",
"diseases" : "HIV",
"statusUsableDate" : "2012-10-01",
"subspecialties" : "Infectious Disease",
"pageid" : 1010,
"timestamp" : "2017-12-03T22:35:58Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Early ART in HIV",
"abbreviation" : "HPTN 052"
},
{
"pageName" : "HS troponin-T to rule out MI",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109714017264",
"published" : "2014-06-17",
"expansion" : null,
"pmid" : "24694529",
"pdfurl" : null,
"title" : "Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction",
"citation" : "Bandstein N, et al. \"Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction\". Journal of the American College of Cardiology. 2014. 63(23):2569-2578.",
"pageid" : 2343,
"timestamp" : "2017-12-03T22:35:59Z",
"subspecialties" : "Emergency Medicine;Cardiology",
"briefDesignDescription" : "High sensitivity troponin for acute chest pain",
"abbreviation" : null,
"trainingLevel" : "Intern",
"briefResultsDescription" : "HS troponin-T is associated with high NPV for MI at 30 days",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"statusUsableDate" : "2015-03-01"
},
{
"diseases" : "Neural Tube Defects",
"briefResultsDescription" : "Perinatal vitamins reduce neural tube defects",
"statusUsableDate" : "2014-09-01",
"subspecialties" : "Obstetrics;Preventive Medicine",
"timestamp" : "2017-12-03T22:36:04Z",
"pageid" : 2142,
"trainingLevel" : "Student",
"briefDesignDescription" : "Perinatal vitamins to prevent neural tube defects",
"abbreviation" : null,
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199212243272602",
"pmid" : "1307234",
"citation" : "Czeizel AE and Dudas I. \"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation\". The New England Journal of Medicine. 1992. 327(26):1832-1835.",
"title" : "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199212243272602",
"pageName" : "Hungarian Prenatal Vitamin Trial",
"expansion" : null,
"published" : "1992-12-24"
},
{
"statusUsableDate" : "2018-08-13",
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "Pilot study with impressive findings, low-quality data",
"abbreviation" : "",
"briefDesignDescription" : "Hydrocortisone, Vit C, and thiamine in sepsis",
"trainingLevel" : "Resident",
"timestamp" : "2023-11-22T21:12:44Z",
"pageid" : 2946,
"subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
"title" : "Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study",
"citation" : "Marik PE, et al. \"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study\". Chest. 2017. 151(6):1229-1238.",
"pdfurl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/pdf",
"pmid" : "27940189",
"published" : "2017-06-01",
"expansion" : "",
"pageName" : "Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock",
"fulltexturl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext"
},
{
"briefDesignDescription" : "Hydrocortisone in severe sepsis",
"abbreviation" : "HYPRESS",
"trainingLevel" : "Resident",
"timestamp" : "2018-02-08T17:14:46Z",
"pageid" : 2860,
"subspecialties" : "Critical Care",
"statusUsableDate" : "2016-11-01",
"diseases" : "Sepsis",
"briefResultsDescription" : "Hydrocortisone not superior to placebo in severe sepsis",
"expansion" : "",
"published" : "2016-10-03",
"pageName" : "HYPRESS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMsa1410639",
"title" : "Effect of hydrocortisone on development of shock among patients with severe sepsis",
"citation" : "Keh D, et al. \"Effect of hydrocortisone on development of shock among patients with severe sepsis\". Journal of the American Medical Association. 2016. 316(17):1775-1785.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMsa1410639",
"pmid" : "27695824"
},
{
"pmid" : "18378519",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801369",
"citation" : "Beckett NS, et al. \"Treatment of hypertension in patients 80 years of age or older\". The New England Journal of Medicine. 2008. 358(18):1887-1898.",
"title" : "Treatment of hypertension in patients 80 years of age or older",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801369",
"pageName" : "HYVET",
"expansion" : "Hypertension in the Very Elderly Trial",
"published" : "2008-05-01",
"briefResultsDescription" : "Trend towards reduction in stroke with treatment (P",
"diseases" : "Hypertension",
"statusUsableDate" : "2015-04-01",
"subspecialties" : "Nephrology;Cardiology;Geriatrics",
"pageid" : 2349,
"timestamp" : "2018-01-11T18:14:28Z",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Elderly HTN treatment",
"abbreviation" : "HYVET"
},
{
"briefDesignDescription" : "IABP in MI and cardiogenic shock",
"abbreviation" : "IABP-SHOCK II",
"trainingLevel" : "Fellow",
"timestamp" : "2017-09-24T13:54:35Z",
"pageid" : 1065,
"subspecialties" : "Cardiology;Critical Care",
"statusUsableDate" : "2012-03-01",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
"briefResultsDescription" : "IABP did not reduce mortality at 30 days",
"expansion" : "Intraaortic Balloon Pump in Cardiogenic Shock II",
"published" : "2012-10-10",
"pageName" : "IABP-SHOCK II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208410",
"title" : "Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock",
"citation" : "Thiele H, et al. \"Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock\". The New England Journal of Medicine. 2012. 367(14):1287-1296.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208410",
"pmid" : "22920912"
},
{
"pmid" : "14736927",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa031644",
"title" : "Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer",
"citation" : "Arriagada R, et al. \"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer\". The New England Journal of Medicine. 2004. 350(4):351-360.",
"pageName" : "IALT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa031644",
"published" : "2004-01-22",
"expansion" : "International Adjuvant Lung Cancer Trial",
"briefResultsDescription" : "Adjuvant cisplatin improves 5-year OS in resected NSCLC",
"diseases" : "Lung Cancer",
"statusUsableDate" : "2019-05-23",
"pageid" : 2503,
"timestamp" : "2019-05-23T17:29:10Z",
"subspecialties" : "Oncology",
"briefDesignDescription" : "Adjuvant cisplatin in resected NSCLC",
"abbreviation" : "IALT",
"trainingLevel" : "Fellow"
},
{
"title" : "Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia",
"citation" : "Treon SP, et al. \"Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia\". The New England Journal of Medicine. 2015. 372(15):1430-1440.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501548",
"pmid" : "25853747",
"published" : "2015-04-09",
"expansion" : null,
"pageName" : "Ibrutinib in Waldenstrom macroglobulinemia",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501548",
"statusUsableDate" : "2015-12-01",
"diseases" : "Lymphoma;Waldenström Macroglobulinemia",
"briefResultsDescription" : "Ibrutinib is safe and effective in previously treated WM",
"abbreviation" : null,
"briefDesignDescription" : "Second-line ibrutinib in WM",
"trainingLevel" : "Fellow",
"timestamp" : "2021-11-04T17:33:05Z",
"pageid" : 2660,
"subspecialties" : "Hematology"
},
{
"diseases" : "Chronic Lymphocytic Leukemia;Small Lymphocytic Lymphoma",
"briefResultsDescription" : "IR improved survival over FCR in untreated CLL",
"statusUsableDate" : "2020-02-09",
"timestamp" : "2020-02-10T07:03:58Z",
"pageid" : 4175,
"subspecialties" : "Hematology;Oncology",
"abbreviation" : "E1912",
"briefDesignDescription" : "Ibrutinib-rituximab vs. FCR in untreated CLL",
"trainingLevel" : "Fellow",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817073",
"pmid" : "31365801",
"title" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
"citation" : "Shanafelt TD, et al. \"Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia\". The New England Journal of Medicine. 2019. 381(5):432-43.",
"pageName" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1817073",
"published" : "2019-08-01",
"expansion" : ""
},
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"briefDesignDescription" : "Colchicine in the first episode of acute pericarditis",
"abbreviation" : "ICAP",
"trainingLevel" : "Intern",
"timestamp" : "2018-10-16T05:02:38Z",
"pageid" : 1729,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2014-01-01",
"diseases" : "Pericarditis",
"briefResultsDescription" : "Colchicine reduces incessant or recurrent acute pericarditis when used in first episode",
"expansion" : "Evaluation of additive benefit of colchicine to conventional therapy in acute pericarditis",
"published" : "2013-10-17",
"pageName" : "ICAP",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208536",
"title" : "A Randomized Trial of Colchicine for Acute Pericarditis",
"citation" : "Imazio M, et al. \"A Randomized Trial of Colchicine for Acute Pericarditis\". The New England Journal of Medicine. 2013. 369(16):1522-1528.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208536",
"pmid" : "23992557"
},
{
"abbreviation" : "IDEAL",
"briefDesignDescription" : "Early vs. late dialysis in CKD",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:36:07Z",
"pageid" : 1020,
"subspecialties" : "Nephrology",
"statusUsableDate" : "2012-10-01",
"diseases" : "Chronic Kidney Disease",
"briefResultsDescription" : "No difference in survival or clinical outcomes",
"expansion" : "Initiating Dialysis Early and Late",
"published" : "2010-08-12",
"pageName" : "IDEAL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000552",
"title" : "A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis",
"citation" : "Cooper BA, et al. \"A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis\". The New England Journal of Medicine. 2010. 363(7):609-619.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000552",
"pmid" : "20581422"
},
{
"published" : "2018-10-11",
"expansion" : "Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1803213",
"pageName" : "IDEAL-ICU",
"citation" : "Barbar SD, et al. \"Timing of renal-replacement therapy in patients with acute kidney injury and sepsis\". The New England Journal of Medicine. 2018. 379(15):1431-1442.",
"title" : "Timing of renal-replacement therapy in patients with acute kidney injury and sepsis",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1803213",
"pmid" : "30304656",
"trainingLevel" : "Resident",
"abbreviation" : "IDEAL-ICU",
"briefDesignDescription" : "Early vs. delayed RRT in septic shock",
"subspecialties" : "Critical Care;Nephrology",
"timestamp" : "2025-06-19T18:33:35Z",
"pageid" : 3746,
"statusUsableDate" : "2019-03-27",
"diseases" : "Acute Kidney Injury;Shock;Sepsis",
"briefResultsDescription" : "No benefit from early initiated RRT in septic shock"
},
{
"pageName" : "IDNT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011303",
"expansion" : "Irbesartan Diabetic Nephropathy Trial",
"published" : "2001-09-20",
"pmid" : "11565517",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011303",
"title" : "Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes",
"citation" : "Lewis EJ, et al. \"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes\". The New England Journal of Medicine. 2001. 345(12):851-860.",
"pageid" : 2670,
"timestamp" : "2017-12-03T22:36:08Z",
"subspecialties" : "Nephrology;Endocrinology",
"abbreviation" : "IDNT",
"briefDesignDescription" : "ARBs in diabetic nephropathy",
"trainingLevel" : "Resident",
"briefResultsDescription" : "ARBs prevent progression of T2DM nephropathy",
"diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
"statusUsableDate" : "2016-01-01"
},
{
"pageid" : 2926,
"timestamp" : "2017-12-03T22:36:10Z",
"subspecialties" : "Cardiology",
"briefDesignDescription" : "iFR vs. FFR for PCI",
"abbreviation" : "iFR-SWEDEHEART",
"trainingLevel" : "Resident",
"briefResultsDescription" : "iFR noninferior to FFR for PCI",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2017-05-01",
"pageName" : "IFR-SWEDEHEART",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1616540",
"expansion" : "Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome",
"published" : "2017-05-11",
"pmid" : "28317438",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1616540",
"title" : "Spontaneous wave-free ratio versus fractional flow reserve to guide PCI",
"citation" : "Gotberg M, et al. \"Spontaneous wave-free ratio versus fractional flow reserve to guide PCI\". The New England Journal of Medicine. 2017. 376(19):1813-1823."
},
{
"expansion" : "IMProved Reduction of Outcomes: Vytorin Efficacy International Trial",
"published" : "2015-06-18",
"pageName" : "IMPROVE-IT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1410489",
"title" : "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes",
"citation" : "Cannon CP, et al. \"Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes\". The New England Journal of Medicine. 2015. 375(25):2387-2397.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489",
"pmid" : "26039521",
"briefDesignDescription" : "Ezetimibe+simvastatin after ACS",
"abbreviation" : "IMPROVE-IT",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-14T19:46:19Z",
"pageid" : 2369,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2015-06-01",
"diseases" : "Hyperlipidemia;Acute Coronary Syndrome;Myocardial Infarction",
"briefResultsDescription" : "Ezetimibe improves CV outcomes when added to statin"
},
{
"citation" : "Richeldi L, et al. \"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis\". The New England Journal of Medicine. 2014. 370(22):2071-2082.",
"title" : "Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402584",
"pmid" : "24836310",
"expansion" : "",
"published" : "2014-05-29",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402584",
"pageName" : "INPULSIS Trials",
"statusUsableDate" : "2018-03-30",
"diseases" : "Idiopathic Pulmonary Fibrosis",
"briefResultsDescription" : "Nintedanib slows progression of IPF",
"trainingLevel" : "Resident",
"abbreviation" : "INPULSIS I and II",
"briefDesignDescription" : "Nintedanib in IPF",
"subspecialties" : "Pulmonology",
"timestamp" : "2018-03-30T14:11:39Z",
"pageid" : 2934
},
{
"expansion" : null,
"published" : "2015-08-27",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506816",
"pageName" : "INSIGHT START",
"citation" : "INSIGHT START Writers. \"Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection\". The New England Journal of Medicine. 2015. 373(9):795-807.",
"title" : "Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506816",
"pmid" : "26192873",
"trainingLevel" : "Student",
"briefDesignDescription" : "Early vs. delayed ART in HIV",
"abbreviation" : "START",
"subspecialties" : "Infectious Disease",
"timestamp" : "2017-12-03T22:36:12Z",
"pageid" : 2468,
"statusUsableDate" : "2016-01-01",
"diseases" : "HIV",
"briefResultsDescription" : "Less complications with early ART"
},
{
"statusUsableDate" : "2013-02-01",
"diseases" : "HIV",
"briefResultsDescription" : "ART reduces tranmission of HIV among MSM",
"trainingLevel" : "intern",
"abbreviation" : "iPrEx",
"briefDesignDescription" : "ART in primary HIV prevention",
"subspecialties" : "Infectious Disease;Preventive Medicine",
"timestamp" : "2017-12-03T22:36:14Z",
"pageid" : 1100,
"citation" : "Grant RM, et al. \"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men\". The New England Journal of Medicine. 2010. 363(27):2587-2599.",
"title" : "Preexposure chemoprophylaxis for HIV prevention in men who have sex with men",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011205",
"pmid" : "21091279",
"published" : "2010-12-30",
"expansion" : "Iniciativa Profilaxis Pre Exposicion (\"Preexposure Prophylaxis Initiative\")",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011205",
"pageName" : "IPrEx"
},
{
"pageid" : 1076,
"timestamp" : "2017-12-03T22:36:15Z",
"subspecialties" : "Hematology;Oncology",
"briefDesignDescription" : "Imatinib vs. IFNα/cytarabine in CML",
"abbreviation" : "IRIS",
"trainingLevel" : "Student",
"briefResultsDescription" : "Imatinib delays disease progression",
"diseases" : "Chronic Myeloid Leukemia;Myeloproliferative Neoplasms",
"statusUsableDate" : "2012-11-01",
"pageName" : "IRIS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa022457",
"expansion" : "International Randomized Study of Interferon and STI571",
"published" : "2003-03-13",
"pmid" : "12637609",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa022457",
"title" : "Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia",
"citation" : "O'Brien SG, et al. \"Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia\". The New England Journal of Medicine. 2003. 384(11):994-1004."
},
{
"statusUsableDate" : "2024-04-30",
"briefResultsDescription" : "IV iron did not reduce transfusion requirements",
"diseases" : "Anemia;Critical Illness",
"abbreviation" : "IRONMAN",
"briefDesignDescription" : "IV iron in critical illness",
"trainingLevel" : "Fellow",
"pageid" : 3651,
"timestamp" : "2025-09-11T19:20:21Z",
"subspecialties" : "Critical Care;Hematology",
"title" : "Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial",
"citation" : "Litton E, et al. \"Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial\". Intensive Care Med. 2016. 42:1715-1722.",
"pmid" : "27686346",
"pdfurl" : "https://link.springer.com/content/pdf/10.1007/s00134-016-4465-6.pdf",
"expansion" : "",
"published" : "2016-11-01",
"pageName" : "IRONMAN",
"fulltexturl" : "https://link.springer.com/article/10.1007%2Fs00134-016-4465-6"
},
{
"timestamp" : "2017-12-03T22:36:17Z",
"pageid" : 2941,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Oral iron vs. placebo in HFrEF and iron deficiency",
"abbreviation" : "IRONOUT-HF",
"trainingLevel" : "Resident",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Oral iron not superior to placebo in HFrEF",
"statusUsableDate" : "2017-07-01",
"pageName" : "IRONOUT-HF",
"fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
"published" : "2017-07-09",
"expansion" : "Iron Repletion Effects on Oxygen Uptake in Heart Failure",
"pdfurl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
"pmid" : "28510680",
"title" : "Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency",
"citation" : "Lewis GD, et al. \"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency\". JAMA. 2017. 317(19):1958-66."
},
{
"timestamp" : "2019-10-17T17:39:50Z",
"pageid" : 4100,
"subspecialties" : "Cardiology",
"abbreviation" : "ISAR-REACT 5",
"briefDesignDescription" : "Ticagrelor vs. prasugrel in ACS",
"trainingLevel" : "Resident",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Prasugrel superior to ticagrelor in acute coronary syndromes",
"statusUsableDate" : "2019-10-17",
"pageName" : "ISAR-REACT 5",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1908973",
"expansion" : "Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5 Trial",
"published" : "2019-09-01",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1908973",
"pmid" : "31475799",
"title" : "Ticagrelor or prasugrel in patients with acute coronary syndromes",
"citation" : "Schupke S et al. \"Ticagrelor or prasugrel in patients with acute coronary syndromes\". New Engl J Med. 2019. 1-11."
},
{
"title" : "Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation",
"citation" : "Fiedler KA et al. \"Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation\". J Am Coll Cardiol. 2015. 65(16):1619-30.",
"pmid" : "25908066",
"pdfurl" : "https://www.jacc.org/doi/pdf/10.1016/j.jacc.2015.02.050",
"expansion" : "Triple therapy in Patients who Require Oral Anticoagulation After Drug-Eluting Stent Implantation",
"published" : "2015-04-28",
"pageName" : "ISAR-TRIPLE",
"fulltexturl" : "http://content.onlinejacc.org/article.aspx?articleID",
"statusUsableDate" : "2016-10-01",
"briefResultsDescription" : "Triple therapy for 6 weeks not superior to 6 months in regards to net clinical outcome",
"diseases" : "Coronary Artery Disease;Atrial Fibrillation",
"abbreviation" : "ISAR-TRIPLE",
"briefDesignDescription" : "Triple therapy for 6w vs. 6m after DES",
"trainingLevel" : "Intern",
"pageid" : 2812,
"timestamp" : "2021-01-30T20:57:06Z",
"subspecialties" : "Cardiology"
},
{
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "No difference between PCI/CABG and medical therapy in stable CAD with moderate-severe ischemia",
"statusUsableDate" : "2021-01-28",
"subspecialties" : "Cardiology",
"timestamp" : "2021-04-07T17:13:36Z",
"pageid" : 4153,
"trainingLevel" : "Resident",
"abbreviation" : "ISCHEMIA",
"briefDesignDescription" : "PCI/CABG vs. medical therapy in stable CAD",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915922",
"pmid" : "32227755",
"citation" : "Maron DJ, et al. \"Initial Invasive or Conservative Strategy for Stable Coronary Disease\". The New England Journal of Medicine. 2020. 382(15):1395-1407.",
"title" : "Initial Invasive or Conservative Strategy for Stable Coronary Disease",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1915922",
"pageName" : "ISCHEMIA",
"published" : "2020-04-09",
"expansion" : "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches"
},
{
"briefDesignDescription" : "Aspirin ± streptokinase in acute MI",
"abbreviation" : "ISIS-2",
"trainingLevel" : "Resident",
"pageid" : 133,
"timestamp" : "2017-12-20T19:04:02Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Mortality benefit of aspirin within 24 hours of acute MI",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"published" : "1988-08-13",
"expansion" : "Second International Study of Infarct Survival",
"pageName" : "ISIS-2",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(88)92833-4/abstract",
"title" : "Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17187 Cases of Suspected Acute Myocardial Infarction",
"citation" : "ISIS-2 Collaborative Group. \"Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17187 Cases of Suspected Acute Myocardial Infarction\". The Lancet. 1988. 332(8607):349-360.",
"pmid" : "2899772",
"pdfurl" : ""
},
{
"briefDesignDescription" : "Aspirin in acute ischemic stroke",
"abbreviation" : "IST",
"trainingLevel" : "Intern",
"timestamp" : "2016-03-07T04:46:48Z",
"pageid" : 132,
"subspecialties" : "Neurology",
"statusUsableDate" : "2012-03-01",
"diseases" : "Stroke",
"briefResultsDescription" : "Mortality benefit with aspirin",
"published" : "1997-05-31",
"expansion" : "International Stroke Trial",
"pageName" : "IST",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(97)04011-7/fulltext",
"title" : "The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke",
"citation" : "IST Collaborative Group. \"The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke\". The Lancet. 1997. 349(9065):1569-1581.",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673697040117.pdf",
"pmid" : "9174558"
},
{
"briefResultsDescription" : "Rosuvastatin delays major CV events",
"diseases" : "Hyperlipidemia;Coronary Artery Disease;Stroke;Transient Ischemic Attack",
"statusUsableDate" : "2012-06-01",
"pageid" : 445,
"timestamp" : "2017-12-03T22:36:21Z",
"subspecialties" : "Cardiology;Preventive Medicine",
"briefDesignDescription" : "Rosuvastatin for primary CV prevention",
"abbreviation" : "JUPITER",
"trainingLevel" : "resident",
"pmid" : "18997196",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807646",
"title" : "Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein",
"citation" : "Ridker PM, et al. \"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein\". The New England Journal of Medicine. 2008. 359(21):2195-2207.",
"pageName" : "JUPITER",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807646",
"expansion" : "Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin",
"published" : "2008-11-20"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1606774",
"pageName" : "KEYNOTE-024",
"expansion" : "",
"published" : "2016-11-10",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1606774",
"pmid" : "27718847",
"citation" : "Reck M, et al. \"Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer\". The New England Journal of Medicine. 2016. 375(19):1824-1833.",
"title" : "Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer",
"subspecialties" : "Oncology",
"timestamp" : "2017-12-03T22:36:23Z",
"pageid" : 2846,
"trainingLevel" : "Resident",
"abbreviation" : "KEYNOTE-024",
"briefDesignDescription" : "Pembrolizumab vs. chemotherapy in NSCLC",
"diseases" : "Lung Cancer",
"briefResultsDescription" : "Pembrolizumab improves survival in advanced NSCLC over chemotherapy",
"statusUsableDate" : "2016-11-01"
},
{
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2101897",
"pageName" : "LAAOS III",
"published" : "2021-06-03",
"expansion" : "Left Atrial Appendage Occlusion Study III",
"pmid" : "33999547",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2101897",
"citation" : "Whitlock RP, et al. \"Left atrial appendage occlusion during cardiac surgery to prevent stroke\". The New England Journal of Medicine. 2021. 384(22):2081-2091.",
"title" : "Left atrial appendage occlusion during cardiac surgery to prevent stroke",
"subspecialties" : "Cardiology",
"pageid" : 4425,
"timestamp" : "2025-05-15T20:40:37Z",
"trainingLevel" : "resident",
"abbreviation" : "LAAOS III",
"briefDesignDescription" : "Surgical LAA occlusion in AF",
"briefResultsDescription" : "Surgical LAA associated with fewer AF events",
"diseases" : "Atrial Fibrillation",
"statusUsableDate" : "2025-04-19"
},
{
"published" : "2016-06-28",
"expansion" : "Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603827",
"pageName" : "LEADER",
"citation" : "Marso SP, et al. \"Liraglutide and cardiovascular outcomes in type 2 diabetes\". The New England Journal of Medicine. 2016. 375(4):311-322.",
"title" : "Liraglutide and cardiovascular outcomes in type 2 diabetes",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603827",
"pmid" : "27295427",
"trainingLevel" : "Resident",
"abbreviation" : "LEADER",
"briefDesignDescription" : "Liraglutide and CVD endpoints in T2DM",
"subspecialties" : "Cardiology;Endocrinology",
"timestamp" : "2023-11-22T21:21:50Z",
"pageid" : 2803,
"statusUsableDate" : "2016-09-01",
"diseases" : "Diabetes Mellitus;Cardiovascular Disease",
"briefResultsDescription" : "Liraglutide reduces CV mortality in T2DM"
},
{
"pmid" : "23902483",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1300439",
"title" : "Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma",
"citation" : "Mateos MV, et al. \"Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma\". The New England Journal of Medicine. 2013. 369(5):438-47.",
"pageName" : "LenDex in High-Risk Smoldering Myeloma",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1300439",
"expansion" : "",
"published" : "2013-08-01",
"briefResultsDescription" : "In flawed trial, LenDex improved OS compared to observation",
"diseases" : "Multiple Myeloma",
"statusUsableDate" : "2018-10-25",
"pageid" : 3706,
"timestamp" : "2018-10-25T17:05:24Z",
"subspecialties" : "Hematology;Oncology",
"briefDesignDescription" : "Lenalidomide/dexamethasone in smoldering MM",
"abbreviation" : "",
"trainingLevel" : "Fellow"
},
{
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Epidural steroids don't improve pain or disability at six weeks",
"diseases" : "Spinal Stenosis",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Epidural steroids in spinal stenosis",
"abbreviation" : "LESS",
"subspecialties" : "Pain Medicine;Physical Medicine and Rehabilitation;Radiology",
"pageid" : 1883,
"timestamp" : "2017-12-03T22:36:26Z",
"citation" : "Friedly JL, et al. \"A randomized trial of epidural glucocorticoid injections for spinal stenosis\". The New England Journal of Medicine. 2014. 371(1):11-21.",
"title" : "A randomized trial of epidural glucocorticoid injections for spinal stenosis",
"pmid" : "24988555",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313265",
"expansion" : "Lumbar Epidural Steroid Injections for Spinal Stenosis",
"published" : "2014-07-03",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313265",
"pageName" : "LESS"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Intensive glycemic therapy in the surgical ICU",
"abbreviation" : "Leuven Surgical Trial",
"subspecialties" : "Critical Care;Endocrinology",
"timestamp" : "2017-01-19T20:18:41Z",
"pageid" : 139,
"statusUsableDate" : "2012-03-01",
"diseases" : "Stress Hyperglycemia",
"briefResultsDescription" : "Intensive glycemic control reduces mortality",
"expansion" : "",
"published" : "2001-11-08",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011300",
"pageName" : "Leuven Surgical Trial",
"citation" : "Van den Berghe G, et al. \"Intensive Insulin Therapy in Critically Ill Patients\". The New England Journal of Medicine. 2001. 345(19):1359-1367.",
"title" : "Intensive Insulin Therapy in Critically Ill Patients",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011300",
"pmid" : "11794168"
},
{
"expansion" : "Cardiovvascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol",
"published" : "2002-03-23",
"pageName" : "LIFE",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08089-3/abstract",
"title" : "Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)",
"citation" : "Dahlof B, et al. \"Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)\". The Lancet. 2002. 359:995-1003.",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(02)08089-3.pdf",
"pmid" : "11937178",
"briefDesignDescription" : "ARB vs. B-blocker in HTN with LVH",
"abbreviation" : "LIFE",
"trainingLevel" : "Student",
"timestamp" : "2024-04-02T17:35:36Z",
"pageid" : 2439,
"subspecialties" : "Nephrology",
"statusUsableDate" : "2024-03-29",
"diseases" : "Hypertension;Cardiovascular Disease;Stroke",
"briefResultsDescription" : "Losartan lowers stroke, MI, or CVD mortality vs. atenolol in HTN with LVH"
},
{
"published" : "2013-07-11",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300874",
"pageName" : "Lo-Coco 2013",
"citation" : "Lo-Coco F, et al. \"Retinoic acid and arsenic trioxide for acute promyelocytic leukemia\". The New England Journal of Medicine. 2013. 369(2):111-21.",
"title" : "Retinoic acid and arsenic trioxide for acute promyelocytic leukemia",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300874",
"pmid" : "23841729",
"trainingLevel" : "Fellow",
"abbreviation" : "",
"briefDesignDescription" : "ATRA-ATO vs. ATRA-chemotherapy in APL",
"subspecialties" : "Hematology;Oncology",
"timestamp" : "2017-12-03T22:36:27Z",
"pageid" : 2285,
"statusUsableDate" : "2014-12-01",
"diseases" : "Leukemia",
"briefResultsDescription" : "ATRA-ATO is noninferior, possibly superior to ATRA-chemotherapy in APL"
},
{
"pageName" : "LoDoCo",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109712054782",
"expansion" : "Low-Dose Colchicine",
"published" : "2013-01-29",
"pdfurl" : null,
"pmid" : "23265346",
"title" : "Low-dose colchicine for secondary prevention of cardiovascular disease",
"citation" : "Nidorf SM, et al. \"Low-dose colchicine for secondary prevention of cardiovascular disease\". Journal of the American College of Cardiology. 2013. 61(4):404-410.",
"timestamp" : "2021-02-18T20:36:25Z",
"pageid" : 1583,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Colchicine for stable CAD",
"abbreviation" : "LoDoCo",
"trainingLevel" : "Resident",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Colcicine may reduce complications in stable CAD",
"statusUsableDate" : "2013-08-01"
},
{
"citation" : "Nidorf SM, et al. \"Colchicine in patients with chronic coronary disease\". The New England Journal of Medicine. 2020. 383(19):1838-1847.",
"title" : "Colchicine in patients with chronic coronary disease",
"pmid" : "32865380",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021372",
"expansion" : "Low Dose Colchicine 2",
"published" : "2020-11-05",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2021372",
"pageName" : "LoDoCo2",
"statusUsableDate" : "2021-02-18",
"briefResultsDescription" : "Colchicine with fewer CV events",
"diseases" : "Coronary Artery Disease",
"trainingLevel" : "Resident",
"abbreviation" : "LoDoCo2",
"briefDesignDescription" : "Colchicine in stable CAD",
"subspecialties" : "Cardiology",
"pageid" : 4359,
"timestamp" : "2024-08-08T17:36:48Z"
},
{
"briefDesignDescription" : "Weight loss and exercise in T2DM",
"abbreviation" : "Look AHEAD",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:37:21Z",
"pageid" : 1546,
"subspecialties" : "Endocrinology;Cardiology",
"statusUsableDate" : "2013-09-01",
"diseases" : "Diabetes Mellitus;Cardiovascular Disease",
"briefResultsDescription" : "No reduction of CVD with weight loss and exercise in T2DM",
"expansion" : "Look Action for HEAlth in Diabetes",
"published" : "2013-07-11",
"pageName" : "Look AHEAD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212914",
"title" : "Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes",
"citation" : "Wing RR, et al. \"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes\". The New England Journal of Medicine. 2013. 369(2):145-154.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212914",
"pmid" : "23796131"
},
{
"citation" : "Lamontagne, F, et al. \"Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit\". New England Journal of Medicine. 2022. 386(25):2387-2398.",
"title" : "Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2200644",
"pmid" : "35704292",
"expansion" : "Lessening Organ Dysfunction with Vitamin C",
"published" : "2022-06-23",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2200644",
"pageName" : "LOVIT",
"statusUsableDate" : "2023-10-28",
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "Vitamin C associated with greater risk of poor ICU outcomes",
"trainingLevel" : "Resident",
"abbreviation" : "LOVIT",
"briefDesignDescription" : "Vitamin C in sepsis",
"subspecialties" : "Critical Care;Infectious Disease",
"timestamp" : "2025-06-19T18:33:56Z",
"pageid" : 5147
},
{
"abbreviation" : "MADIT-CRT",
"briefDesignDescription" : "CRT in HFrEF with QRS ≥130 msec and mild symptoms",
"trainingLevel" : "Resident",
"pageid" : 1780,
"timestamp" : "2017-12-03T22:37:23Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2014-04-01",
"briefResultsDescription" : "CRT reduces mortality or HF complications in mildly symptomatic HFrEF with prolonged QRS",
"diseases" : "Heart Failure",
"published" : "2009-10-01",
"expansion" : "Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy",
"pageName" : "MADIT-CRT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906431",
"title" : "Cardiac-resynchronization therapy for the prevention of heart-failure events",
"citation" : "Moss AJ, et al. \"Cardiac-resynchronization therapy for the prevention of heart-failure events\". The New England Journal of Medicine. 2009. 361(14):1329-1338.",
"pmid" : "19723701",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906431"
},
{
"statusUsableDate" : "2012-03-01",
"diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
"briefResultsDescription" : "ICD improves survival in post-MI patients with LVEF≤30%",
"trainingLevel" : "Resident",
"briefDesignDescription" : "ICD post-MI with HFrEF",
"abbreviation" : "MADIT-II",
"subspecialties" : "Cardiology",
"timestamp" : "2019-03-07T17:25:42Z",
"pageid" : 385,
"citation" : "Moss AJ, et al. \"Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction\". The New England Journal of Medicine. 2002. 346(12):877-883.",
"title" : "Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013474",
"pmid" : "11907286",
"expansion" : "Multicenter Automatic Defibrillator Implantation Trial II",
"published" : "2002-03-21",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013474",
"pageName" : "MADIT-II"
},
{
"statusUsableDate" : "2013-10-01",
"briefResultsDescription" : "Rivaroxaban similar to LMWH for prophylaxis, caused more bleeding",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"trainingLevel" : "Resident",
"abbreviation" : "MAGELLAN",
"briefDesignDescription" : "Rivaroxaban vs. LMWH for VTE prophylaxis",
"subspecialties" : "Hematology",
"pageid" : 1272,
"timestamp" : "2017-12-03T22:37:25Z",
"citation" : "Cohen AT, et al. \"Rivaroxaban for thromboprophylaxis in acutely ill medical patients\". The New England Journal of Medicine. 2013. 368(6):513-523.",
"title" : "Rivaroxaban for thromboprophylaxis in acutely ill medical patients",
"pmid" : "23388003",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1111096",
"published" : "2013-02-07",
"expansion" : "Multicenter, Randomized, Parallel Group Efficacy and Safety Study for the Prevention of Venous Thromboembolism in Hospitalized Acutely Ill Medical Patients Comparing Rivaroxaban with Enoxaparin",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1111096",
"pageName" : "MAGELLAN"
},
{
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"briefResultsDescription" : "Rivaroxaban does not prevent VTE in medically ill patients",
"statusUsableDate" : "2018-09-13",
"timestamp" : "2018-10-08T21:48:25Z",
"pageid" : 3699,
"subspecialties" : "Hematology;Cardiology",
"abbreviation" : "MARINER",
"briefDesignDescription" : "Rivaroxaban VTE ppx after medical admission",
"trainingLevel" : "Resident",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1805090",
"pmid" : "30145946",
"title" : "Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness",
"citation" : "Spyropoulos AC, et al. \"Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness\". The New England Journal of Medicine. 2018. e-published 2018-08-26:1-10.",
"pageName" : "MARINER",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1805090",
"published" : "2017-08-27",
"expansion" : "Medically Ill Patient Assessment of Rivaroxaban versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk"
},
{
"trainingLevel" : "Intern",
"briefDesignDescription" : "US screening for AAA in men",
"abbreviation" : "MASS",
"subspecialties" : "Preventive Medicine;Radiology",
"pageid" : 2397,
"timestamp" : "2017-12-03T22:37:27Z",
"statusUsableDate" : "2015-10-01",
"briefResultsDescription" : "US screening reduces AAA mortality in men",
"diseases" : "Abdominal Aortic Aneurysm",
"published" : "2009-06-24",
"expansion" : "Multicentre Aneurysm Screening Study",
"fulltexturl" : "http://www.bmj.com/content/338/bmj.b2307.long",
"pageName" : "MASS",
"citation" : "Thompson SG, et al. \"Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study\". BMJ. 2009. 338:b2307.",
"title" : "Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study",
"pmid" : "19553269",
"pdfurl" : "http://www.bmj.com/content/338/bmj.b2307.full.pdf"
},
{
"statusUsableDate" : "2021-10-31",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Abbreviated DAPT non-inferior or superior for CVD and/or bleeding events",
"trainingLevel" : "resident",
"briefDesignDescription" : "Abbreviated DAPT in high-risk bleeding",
"abbreviation" : "MASTER DAPT",
"subspecialties" : "Cardiology;Hematology",
"timestamp" : "2021-11-06T00:38:08Z",
"pageid" : 4443,
"citation" : "Valgimigli M, et al. \"Dual antiplatelet therapy after PCI in patients at high bleeding risk\". The New England Journal of Medicine. 2021. 385(18):1643-1655.",
"title" : "Dual antiplatelet therapy after PCI in patients at high bleeding risk",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2108749",
"pmid" : "34449185",
"expansion" : "Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation with an Abbreviated versus Standard DAPT Regimen",
"published" : "2021-10-28",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2108749",
"pageName" : "MASTER DAPT"
},
{
"expansion" : "Management of Atherothrombosis with Clopidogrel in High-risk patients",
"published" : "2004-07-24",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)16721-4/fulltext",
"pageName" : "MATCH",
"citation" : "Diener HC, et al. \"Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial\". The Lancet. 2004. 364(9431):331-337.",
"title" : "Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial",
"pmid" : "15276392",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673604167214.pdf",
"trainingLevel" : "student",
"abbreviation" : "MATCH",
"briefDesignDescription" : "ASA/clopidogrel vs. clopidogrel in stroke",
"subspecialties" : "Neurology",
"pageid" : 1125,
"timestamp" : "2017-12-03T22:37:28Z",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "More major bleeding but no greater efficacy with combination therapy",
"diseases" : "Stroke"
},
{
"abbreviation" : "MATRIX Antithrombin",
"briefDesignDescription" : "Heparin vs. bivalirudin in PCI",
"trainingLevel" : "Resident",
"pageid" : 2485,
"timestamp" : "2023-08-03T18:17:01Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2023-07-29",
"briefResultsDescription" : "Bivalirudin equivalent to heparin for PCI",
"diseases" : "Coronary Artery Disease",
"published" : "2015-09-10",
"expansion" : "Minimizing Adverse haemmhorragic events by TRansradial access site and systemic Implementation of angioX (MATRIX)",
"pageName" : "MATRIX Antithrombin",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1507854",
"title" : "Bivalirudin or unfractionated heparin in acute coronary syndromes",
"citation" : "Valgimigli M, et al. \"Bivalirudin or unfractionated heparin in acute coronary syndromes\". New England Journal of Medicine. 2015. 373(11):997-1009.",
"pmid" : "26324049",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1507854"
},
{
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2702145",
"pageName" : "MERINO",
"expansion" : "",
"published" : "2018-09-11",
"pmid" : "30208454",
"pdfurl" : "",
"citation" : "Harris PNA, et al. \"Effect of piperacillin-tazobactam vs. meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae Bloodstream Infection and ceftriaxone resistance: A randomized clinical trial\". JAMA. 2018. 320(10):984-994.",
"title" : "Effect of piperacillin-tazobactam vs. meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae Bloodstream Infection and ceftriaxone resistance: A randomized clinical trial",
"subspecialties" : "Infectious Disease",
"pageid" : 4422,
"timestamp" : "2022-04-21T19:13:41Z",
"trainingLevel" : "Resident",
"abbreviation" : "MERINO",
"briefDesignDescription" : "Piperacillin-tazobactam for ESBL bacteremia",
"briefResultsDescription" : "Piperacillin-tazobactam is inferior to meropenem for ESBL bacteremia",
"diseases" : "ESBL Bacteremia",
"statusUsableDate" : "2022-04-21"
},
{
"published" : "1999-06-12",
"expansion" : "Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140673699044402",
"pageName" : "MERIT-HF",
"citation" : "Fagerberg B, et al. \"Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure\". The Lancet. 1999. 353(9169):2001-7.",
"title" : "Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure",
"pdfurl" : "",
"pmid" : "10376614",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Metoprolol in HFrEF",
"abbreviation" : "MERIT-HF",
"subspecialties" : "Cardiology",
"timestamp" : "2015-08-24T03:51:03Z",
"pageid" : 130,
"statusUsableDate" : "2012-03-01",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Metoprolol improves survival in NYHA II-IV HFrEF"
},
{
"subspecialties" : "Surgery;Physical Medicine and Rehabilitation",
"pageid" : 1429,
"timestamp" : "2017-12-03T22:37:29Z",
"trainingLevel" : "Student",
"abbreviation" : "METEOR",
"briefDesignDescription" : "Surgery vs. PT in OA with meniscal tear",
"briefResultsDescription" : "Surgery no better than PT alone",
"diseases" : "Meniscal Tear;Osteoarthritis",
"statusUsableDate" : "2013-09-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1301408",
"pageName" : "METEOR",
"published" : "2013-05-02",
"expansion" : "Meniscal Tear in Osteoarthritis Research",
"pmid" : "23506518",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1301408",
"citation" : "Katz JN, et al. \"Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis\". The New England Journal of Medicine. 2013. 368(18):1675-1684.",
"title" : "Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis"
},
{
"citation" : "Suri RM, et al. \"Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets\". JAMA. 2013. 310(6):609-616.",
"title" : "Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets",
"pmid" : "23942679",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/927436/joi130034.pdf",
"expansion" : "Mitral Regurgitation International Database",
"published" : "2013-08-14",
"fulltexturl" : "",
"pageName" : "MIDA",
"statusUsableDate" : "2014-02-01",
"briefResultsDescription" : "Early surgery reduces mortality in MR",
"diseases" : "Mitral Regurgitation",
"trainingLevel" : "Resident",
"abbreviation" : "MIDA",
"briefDesignDescription" : "Early surgery for MR",
"subspecialties" : "Cardiology",
"pageid" : 1787,
"timestamp" : "2017-12-03T22:37:31Z"
},
{
"briefResultsDescription" : "Antipsychotics don't reduce days without delirium or coma in ICU",
"diseases" : "Delirium;Critical Illness",
"statusUsableDate" : "2018-11-30",
"subspecialties" : "Psychiatry;Critical Care",
"pageid" : 3741,
"timestamp" : "2022-11-02T14:33:46Z",
"trainingLevel" : "resident",
"abbreviation" : "MIND-USA",
"briefDesignDescription" : "Antipsychotics in ICU delirium",
"pmid" : "30346242",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1808217",
"citation" : "Girard TD, et al. \"Haloperidol and ziprasidone for treatment of delirium in critical illness\". The New England Journal of Medicine. 2018. ePub 2018-10-22:1-12.",
"title" : "Haloperidol and ziprasidone for treatment of delirium in critical illness",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1808217",
"pageName" : "MIND-USA",
"published" : "2018-10-22",
"expansion" : "Modifying the Impact of ICU-Associated Neurological Dysfunction–USA"
},
{
"fulltexturl" : "http://jama.ama-assn.org/content/285/13/1711.long",
"pageName" : "MIRACL",
"published" : "2001-04-04",
"expansion" : "Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering",
"pdfurl" : "http://jama.ama-assn.org/content/285/13/1711.full.pdf",
"pmid" : "11277825",
"citation" : "Schwartz GG, et al. \"Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes\". Journal of the American Medical Association. 2001. 285(13):1711-1718.",
"title" : "Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes",
"subspecialties" : "Cardiology",
"timestamp" : "2020-10-29T17:14:07Z",
"pageid" : 432,
"trainingLevel" : "Resident",
"abbreviation" : "MIRACL",
"briefDesignDescription" : "Atorvastatin in UA/NSTEMI",
"diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Hyperlipidemia",
"briefResultsDescription" : "Atorvastatin reduced rate of CV events after UA/NSTEMI",
"statusUsableDate" : "2012-03-01"
},
{
"citation" : "Rahman NM, et al. \"Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection\". The New England Journal of Medicine. 2011. 365(6):518-526.",
"title" : "Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012740",
"pmid" : "21830966",
"published" : "2011-08-11",
"expansion" : "Second MIST trial",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1012740",
"pageName" : "MIST2",
"statusUsableDate" : "2020-12-31",
"diseases" : "Pleural Infection",
"briefResultsDescription" : "tPA+DNase with greatest reduction in size of effusion",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "tPA and/or DNase for pleural infection",
"abbreviation" : "MIST2",
"subspecialties" : "Pulmonology;Infectious Disease",
"timestamp" : "2021-01-06T13:53:52Z",
"pageid" : 3757
},
{
"subspecialties" : "Emergency Medicine;Infectious Disease",
"timestamp" : "2024-05-18T01:31:16Z",
"pageid" : 4102,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Antibiotic stewardship in respiratory infections",
"abbreviation" : "MITIGATE",
"diseases" : "Acute Respiratory Infection",
"briefResultsDescription" : "Antibiotic stewardship reduced unnecessary prescriptions",
"statusUsableDate" : "2024-04-29",
"fulltexturl" : "https://onlinelibrary.wiley.com/doi/abs/10.1111/acem.13690",
"pageName" : "MITIGATE",
"published" : "2019-07-01",
"expansion" : "A Multifaceted Intervention to Improve Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings",
"pdfurl" : "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.13690?download",
"pmid" : "31215721",
"citation" : "Yadav K, et al. \"A Multifaceted Intervention Improves Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings\". Academic Emergency Medicine. 2019. 26(7):719-731.",
"title" : "A Multifaceted Intervention Improves Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings"
},
{
"timestamp" : "2023-04-12T13:12:04Z",
"pageid" : 2931,
"subspecialties" : "Gastroenterology;Infectious Disease",
"abbreviation" : "MODIFY I and II",
"briefDesignDescription" : "Bezlotoxumab for C. diff recurrence prevention",
"trainingLevel" : "Resident",
"diseases" : "Clostridium difficile",
"briefResultsDescription" : "Bezlotoxumab lowers recurrence rate of C. diff infection",
"statusUsableDate" : "2017-05-01",
"pageName" : "MODIFY I and II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602615",
"published" : "2017-01-26",
"expansion" : "",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602615",
"pmid" : "28121498",
"title" : "Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection",
"citation" : "Wilcox MH, et al. \"Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection\". New England Journal of Medicine. 2017. 376(4):305-317."
},
{
"title" : "Two-year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure",
"citation" : "Mehra MR, et al. \"Two-year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure\". The New England Journal of Medicine. 2018. 378(15):1386-95.",
"pmid" : "29526139",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800866",
"expansion" : "Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3",
"published" : "2018-04-12",
"pageName" : "MOMENTUM 3",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800866",
"statusUsableDate" : "2018-06-29",
"briefResultsDescription" : "Centrifugal-flow LVAD superior to axial-flow LVAD in advanced HF",
"diseases" : "Heart Failure",
"abbreviation" : "MOMENTUM 3",
"briefDesignDescription" : "Centrifugal-flow LVAD vs. axial-flow LVAD in advanced HF",
"trainingLevel" : "Resident",
"pageid" : 3605,
"timestamp" : "2018-06-29T18:08:40Z",
"subspecialties" : "Cardiology"
},
{
"statusUsableDate" : "2014-02-01",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"briefResultsDescription" : "Low-dose tPA reduces pulmonary HTN in submassive PE",
"trainingLevel" : "Intern",
"abbreviation" : "MOPETT",
"briefDesignDescription" : "Low-dose tPA for submassive PE",
"subspecialties" : "Critical Care;Pulmonology;Cardiology",
"timestamp" : "2017-12-03T22:37:34Z",
"pageid" : 1785,
"citation" : "Sharifi M, et al. \"Moderate pulmonary embolism treated with thrombolysis\". The American Journal of Cardiology. 2013. 111(2):273-277.",
"title" : "Moderate pulmonary embolism treated with thrombolysis",
"pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0002-9149/PIIS0002914912022059.pdf",
"pmid" : "23102885",
"published" : "2013-01-15",
"expansion" : "Moderate Pulmonary Embolism Treated with Thrombolysis",
"fulltexturl" : "http://www.ajconline.org/article/S0002-9149%2812%2902205-9/fulltext",
"pageName" : "MOPETT"
},
{
"briefResultsDescription" : "No difference between groups at 2 years",
"diseases" : "Osteoarthritis",
"statusUsableDate" : "2012-11-01",
"subspecialties" : "Surgery;Physical Medicine and Rehabilitation",
"pageid" : 1055,
"timestamp" : "2017-12-03T22:37:42Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Arthroscopy in knee OA",
"abbreviation" : "",
"pmid" : "12110735",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013259",
"citation" : "Moseley JB, et al. \"A controlled trial of arthroscopic surgery for osteoarthritis of the knee\". The New England Journal of Medicine. 2002. 347(2):81-88.",
"title" : "A controlled trial of arthroscopic surgery for osteoarthritis of the knee",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013259",
"pageName" : "Moseley Trial",
"published" : "2002-07-11",
"expansion" : ""
},
{
"subspecialties" : "Cardiology",
"pageid" : 2710,
"timestamp" : "2023-03-30T22:49:47Z",
"trainingLevel" : "Resident",
"abbreviation" : "MOST",
"briefDesignDescription" : "Dual- vs. single-chamber pacing in bradycardia",
"briefResultsDescription" : "Dual-chamber pacing superior to single-chamber ventricular pacing",
"diseases" : "Bradycardia",
"statusUsableDate" : "2023-03-30",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013040",
"pageName" : "MOST",
"expansion" : "Ventricular pacing or dual-chamber pacing for sinus-node dysfunction",
"published" : "2002-06-13",
"pmid" : "12063369",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013040",
"citation" : "Lamas GA, et al. \"Ventricular pacing or dual-chamber pacing for sinus-node dysfunction\". The New England Journal of Medicine. 2002. 346(24):1854-62.",
"title" : "Ventricular pacing or dual-chamber pacing for sinus-node dysfunction"
},
{
"subspecialties" : "Oncology",
"timestamp" : "2017-12-03T22:37:36Z",
"pageid" : 2816,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Gemcitabine/nab-paclitaxel in pancreatic cancer",
"abbreviation" : "MPACT",
"diseases" : "Pancreatic Cancer",
"briefResultsDescription" : "Gemcicabine/nab-paclitaxel improves OS in metastatic pancreatic cancer compared to gemcitabine",
"statusUsableDate" : "2016-08-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1304369",
"pageName" : "MPACT",
"published" : "2013-10-31",
"expansion" : "Metastatic Pancreatic Adenocarcinoma Clinical Trial",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1304369",
"pmid" : "24131140",
"citation" : "Von Hoff DD, et al. \"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine\". The New England Journal of Medicine. 2013. 369(18):1691-1703.",
"title" : "Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1411587",
"pmid" : "25517348",
"title" : "A randomized trial of intraarterial treatment for acute ischemic stroke",
"citation" : "Berkhemer OA, et al. \"A randomized trial of intraarterial treatment for acute ischemic stroke\". The New England Journal of Medicine. 2015. 372(1):11-20.",
"pageName" : "MR CLEAN",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1411587",
"published" : "2015-01-01",
"expansion" : "",
"diseases" : "Stroke",
"briefResultsDescription" : "IA therapy improves outcome without increased mortality or ICH",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2016-03-10T04:00:44Z",
"pageid" : 2373,
"subspecialties" : "Neurology",
"abbreviation" : "MR CLEAN",
"briefDesignDescription" : "IA therapy for proximal large artery strokes",
"trainingLevel" : "Intern"
},
{
"citation" : "Kidwell CS, et al. \"A trial of imaging selection and endovascular treatment for ischemic stroke\". The New England Journal of Medicine. 2013. 368(10):914-923.",
"title" : "A trial of imaging selection and endovascular treatment for ischemic stroke",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212793",
"pmid" : "23394476",
"expansion" : "",
"published" : "2013-03-07",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212793",
"pageName" : "MR RESCUE",
"statusUsableDate" : "2015-05-01",
"diseases" : "Stroke",
"briefResultsDescription" : "Imaging did not id pts who would benefit from endovascular thrombectomy for acute ischemic stroke.",
"trainingLevel" : "Fellow",
"abbreviation" : "MR RESCUE",
"briefDesignDescription" : "Thrombectomy vs. standard care in stroke",
"subspecialties" : "Neurology",
"timestamp" : "2017-12-03T22:37:37Z",
"pageid" : 2363
},
{
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "CHD risk modification did not lower 7 year mortality",
"statusUsableDate" : "2021-06-24",
"subspecialties" : "Cardiology;Preventive Medicine",
"timestamp" : "2021-06-25T23:51:15Z",
"pageid" : 2455,
"trainingLevel" : "Student",
"abbreviation" : "MRFIT",
"briefDesignDescription" : "CHD risk modification for CHD mortality prevention",
"pdfurl" : "",
"pmid" : "7050440",
"citation" : "MRFIT Writers. \"Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group\". JAMA. 1982. 248(12):1465-1477.",
"title" : "Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/377969",
"pageName" : "MRFIT",
"expansion" : "Multiple Risk Factor Intervention Trial",
"published" : "1982-09-24"
},
{
"abbreviation" : "MSH",
"briefDesignDescription" : "Hydroxyurea in sickle-cell disease",
"trainingLevel" : "Student",
"timestamp" : "2021-01-05T21:08:12Z",
"pageid" : 2797,
"subspecialties" : "Hematology",
"statusUsableDate" : "2016-07-01",
"diseases" : "Sickle Cell Disease",
"briefResultsDescription" : "Hydroxyurea ↓frequency of painful crises in SCD",
"expansion" : "Multicenter Study of Hydroxyurea in Sickle-Cell Anemia",
"published" : "1995-05-18",
"pageName" : "MSH",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199505183322001",
"title" : "Effect of hydroxyurea on the frequency of painful crises in sickle-cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle-Cell Anemia",
"citation" : "Charache S, et al. \"Effect of hydroxyurea on the frequency of painful crises in sickle-cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle-Cell Anemia\". The New England Journal of Medicine. 1995. 332(20):1317-1322.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199505183322001",
"pmid" : "7715639"
},
{
"abbreviation" : "MSLT-I",
"briefDesignDescription" : "SLNB vs. surveillance in melanoma",
"trainingLevel" : "Fellow",
"pageid" : 3521,
"timestamp" : "2024-03-28T20:26:52Z",
"subspecialties" : "Surgery;Oncology",
"statusUsableDate" : "2024-03-28",
"briefResultsDescription" : "SLBN did not improve melanoma-specific survival compared to observation",
"diseases" : "Melanoma",
"published" : "2014-02-13",
"expansion" : "Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma",
"pageName" : "MSLT-1",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1310460",
"title" : "Multicenter Selective Lymphadenectomy Trial",
"citation" : "Morton DL, et al. \"Multicenter Selective Lymphadenectomy Trial\". The New England Journal of Medicine. 2014. 370(7):599-609.",
"pmid" : "24521106",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1310460"
},
{
"trainingLevel" : "Resident",
"abbreviation" : "MUSTT",
"briefDesignDescription" : "ICD and antiarrhythmics in mild HFrEF and NSVT",
"subspecialties" : "Cardiology",
"pageid" : 2872,
"timestamp" : "2022-12-01T19:00:15Z",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "ICD placement better than antiarrhythmics in mild HF with NSVT",
"diseases" : "Ventricular Tachycardia",
"published" : "1999-12-16",
"expansion" : "Multicenter Unsustained Tachycardia Trial",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199912163412503",
"pageName" : "MUSTT",
"citation" : "Buxton AE et al. \"A randomized study of the prevention of sudden death in patients with coronary artery disease\". New Engl J Med. 1999. 341(25):1882-90.",
"title" : "A randomized study of the prevention of sudden death in patients with coronary artery disease",
"pmid" : "10601507",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199912163412503"
},
{
"expansion" : "North American AIDS Cohort Collaboration on Research and Design",
"published" : "2009-04-30",
"pageName" : "NA-ACCORD",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807252",
"title" : "Effect of Early vs. Deferred Antiretroviral therapy for HIV on Survival",
"citation" : "Kitahata MM, et al. \"Effect of Early vs. Deferred Antiretroviral therapy for HIV on Survival\". The New England Journal of Medicine. 2009. 360(18):1815-1826.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807252",
"pmid" : "19339714",
"abbreviation" : "NA-ACCORD",
"briefDesignDescription" : "Early vs. delayed ART in HIV",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:37:44Z",
"pageid" : 1039,
"subspecialties" : "Infectious Disease",
"statusUsableDate" : "2014-11-01",
"diseases" : "HIV",
"briefResultsDescription" : "Early ART in HIV improves survival"
},
{
"citation" : "Wong A. \"The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose\". Hepatology. 2019. 69(2):774-784.",
"title" : "The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose",
"pmid" : "30125376",
"pdfurl" : "https://aasldpubs.onlinelibrary.wiley.com/doi/epdf/10.1002/hep.30224",
"expansion" : "",
"published" : "2019-02-02",
"fulltexturl" : "https://doi.org/10.1002/hep.30224",
"pageName" : "NACSTOP",
"statusUsableDate" : "2022-07-15",
"briefResultsDescription" : "No difference between 12 vs. 20 hours of NAC for APAP overdose",
"diseases" : "Acetaminophen Overdose",
"trainingLevel" : "resident",
"abbreviation" : "NACSTOP",
"briefDesignDescription" : "12 vs. 20 hours of NAC in APAP overdose",
"subspecialties" : "Emergency Medicine;Critical Care",
"pageid" : 4063,
"timestamp" : "2022-07-29T01:52:18Z"
},
{
"published" : "1998-11-12",
"expansion" : "North American Symptomatic Carotid Endarterectomy Trial",
"pageName" : "NASCET",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199811123392002",
"title" : "Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis",
"citation" : "Barnett HJ, et al. \"Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis\". The New England Journal of Medicine. 1998. 339(20):1415-25.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199811123392002",
"pmid" : "9811916",
"briefDesignDescription" : "CEA in symptomatic carotid stenosis",
"abbreviation" : "NASCET",
"trainingLevel" : "Intern",
"timestamp" : "2020-08-01T21:47:56Z",
"pageid" : 128,
"subspecialties" : "Surgery;Neurology",
"statusUsableDate" : "2012-03-01",
"diseases" : "Carotid Stenosis;Stroke",
"briefResultsDescription" : "CEA reduces the risk of death or stroke in symptomatic 50-69% carotid stenosis"
},
{
"pageid" : 3665,
"timestamp" : "2022-10-19T13:06:44Z",
"subspecialties" : "Neurology",
"briefDesignDescription" : "Rivaroxaban vs. ASA for ESUS (stroke)",
"abbreviation" : "NAVIGATE ESUS",
"trainingLevel" : "Resident",
"briefResultsDescription" : "Rivaroxaban is not superior to ASA for stroke",
"diseases" : "Stroke",
"statusUsableDate" : "2022-07-28",
"pageName" : "NAVIGATE ESUS",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1802686",
"published" : "2018-06-07",
"expansion" : "New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source\nof Undetermined Source",
"pmid" : "29766772",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1802686",
"title" : "Rivaroxaban for stroke prevention after embolic stroke of undetermined source",
"citation" : "Hart RG, et al. \"Rivaroxaban for stroke prevention after embolic stroke of undetermined source\". The New England Journal of Medicine. 2018. 378(23):2191-2201."
},
{
"expansion" : "The National Cooperative Dialysis Study",
"published" : "1981-11-12",
"pageName" : "NCDS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198111123052003",
"title" : "Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study",
"citation" : "Lowrie EG, et al. \"Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study\". The New England Journal of Medicine. 1981. 305(20):1176-1181.",
"pmid" : "7027040",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198111123052003",
"briefDesignDescription" : "Dialysis prescriptions in ESRD",
"abbreviation" : "NCDS",
"trainingLevel" : "Fellow",
"pageid" : 504,
"timestamp" : "2017-12-03T22:37:45Z",
"subspecialties" : "Nephrology",
"statusUsableDate" : "2013-07-01",
"briefResultsDescription" : "Low BUN better tolerated, fewer hospitalizations",
"diseases" : "Chronic Kidney Disease"
},
{
"expansion" : "Nitrate’s Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction",
"published" : "2015-12-10",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1510774",
"pageName" : "NEAT-HFpEF",
"citation" : "Redfield MM, et al. \"Isosorbide mononitrate in heart failure with preserved ejection fraction\". New England Journal of Medicine. 2015. 373(24):2314-2324.",
"title" : "Isosorbide mononitrate in heart failure with preserved ejection fraction",
"pmid" : "26549714",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510774",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Nitrates for activity tolerance in HFpEF",
"abbreviation" : "NEAT-HFpEF",
"subspecialties" : "Cardiology",
"pageid" : 2668,
"timestamp" : "2017-12-03T22:37:47Z",
"statusUsableDate" : "2016-04-01",
"briefResultsDescription" : "Nitrates do not improve activity tolerance in HFpEF",
"diseases" : "Heart Failure"
},
{
"briefResultsDescription" : "LVRS benefits apical emphysema and those with low exercise function",
"diseases" : "Chronic Obstructive Pulmonary Disease;Emphysema",
"statusUsableDate" : "2013-08-01",
"subspecialties" : "Surgery;Pulmonology",
"pageid" : 1604,
"timestamp" : "2017-12-03T22:37:49Z",
"trainingLevel" : "Resident",
"abbreviation" : "NETT",
"briefDesignDescription" : "Lung volume reduction in COPD",
"pmid" : "12759479",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030287",
"citation" : "Fishman A, et al. \"A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema\". The New England Journal of Medicine. 2003. 348(21):2059-2073.",
"title" : "A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030287",
"pageName" : "NETT",
"expansion" : "National Emphysema Treatment Trial",
"published" : "2003-05-22"
},
{
"diseases" : "Stress Hyperglycemia",
"briefResultsDescription" : "Increased mortality targeting euglycemia",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Critical Care;Endocrinology",
"timestamp" : "2020-02-06T15:48:50Z",
"pageid" : 26,
"trainingLevel" : "Intern",
"abbreviation" : "NICE-SUGAR",
"briefDesignDescription" : "Intensive glycemic therapy in ICU",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810625",
"pmid" : "19318384",
"citation" : "Finfer S, et al. \"Intensive versus conventional glucose control in critically ill patients\". The New England Journal of Medicine. 2009. 360(13):1283-1297.",
"title" : "Intensive versus conventional glucose control in critically ill patients",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810625",
"pageName" : "NICE-SUGAR",
"expansion" : "Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation",
"published" : "2009-03-26"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199512143332401",
"pmid" : "7477192",
"citation" : "Marler JR, et al. \"Tissue Plasminogen Activator for Acute Ischemic Stroke\". The New England Journal of Medicine. 1995. 333(24):1581-1587.",
"title" : "Tissue Plasminogen Activator for Acute Ischemic Stroke",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199512143332401",
"pageName" : "NINDS",
"published" : "1995-12-14",
"expansion" : "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study",
"diseases" : "Stroke",
"briefResultsDescription" : "tPA within 3 hours improved outcomes",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Neurology;Critical Care",
"timestamp" : "2015-08-24T19:41:34Z",
"pageid" : 131,
"trainingLevel" : "MedicalStudent",
"abbreviation" : "NINDS",
"briefDesignDescription" : "tPA in ischemic stroke"
},
{
"expansion" : "National Lung Screening Trial",
"published" : "2011-08-04",
"pageName" : "NLST",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102873",
"title" : "Reduced lung cancer mortality with low-dose computed tomographic screening",
"citation" : "Berg CD, et al. \"Reduced lung cancer mortality with low-dose computed tomographic screening\". The New England Journal of Medicine. 2011. 365(5):395-409.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102873",
"pmid" : "21714641",
"briefDesignDescription" : "CT vs. CXR in lung cancer screening",
"abbreviation" : "NLST",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:37:50Z",
"pageid" : 980,
"subspecialties" : "Pulmonology;Oncology;Preventive Medicine",
"statusUsableDate" : "2012-10-01",
"diseases" : "Lung Cancer",
"briefResultsDescription" : "Low-dose CT reduces lung cancer mortality compared to CXR"
},
{
"abbreviation" : "NordICC",
"briefDesignDescription" : "Invitations for screening colonoscopy",
"trainingLevel" : "resident",
"timestamp" : "2022-12-01T20:16:39Z",
"pageid" : 5065,
"subspecialties" : "Preventive Medicine",
"statusUsableDate" : "2022-10-14",
"diseases" : "Colorectal Cancer",
"briefResultsDescription" : "Invitations for screening colonoscopy don't lower mortality",
"expansion" : "Nordic-European Initiative on Colorectal Cancer",
"published" : "2022-10-09",
"pageName" : "NordICC",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2208375",
"title" : "Effect of colonoscopy screening on risks of colorectal cancer and related death",
"citation" : "Bretthauer M, et al. \"Effect of colonoscopy screening on risks of colorectal cancer and related death\". The New England Journal of Medicine. 2022. 1-10.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2208375",
"pmid" : "36214590"
},
{
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Drug-eluting stent superior to bare-metal stent in CAD",
"statusUsableDate" : "2016-10-01",
"timestamp" : "2021-01-30T21:12:28Z",
"pageid" : 2832,
"subspecialties" : "Cardiology",
"abbreviation" : "NORSTENT",
"briefDesignDescription" : "Drug-eluting stent vs. bare-metal stent in CAD",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/pdf/full/10.1056/NEJMoa1607991",
"pmid" : "27572953",
"title" : "Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease",
"citation" : "Bonaa KH, et al. \"Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease\". The New England Journal of Medicine. 2016. 375:1242-1252.",
"pageName" : "NORSTENT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1607991",
"published" : "2016-08-30",
"expansion" : "Drug-Eluting or Bare-Metal Stents for Percutaneous Coronary Intervention in Stable or Unstable Coronary Artery Disease"
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"fulltexturl" : "http://annals.org/article.aspx?articleid",
"pageName" : "NOTT",
"expansion" : "Nocturnal Oxygen Therapy Trial",
"published" : "1980-09-01",
"pmid" : "6776858",
"pdfurl" : "",
"citation" : "NOTT Group. \"Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group\". Annals of Internal Medicine. 1980. 93(3):91-398.",
"title" : "Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group",
"subspecialties" : "Pulmonology",
"pageid" : 1788,
"timestamp" : "2017-12-03T22:37:53Z",
"trainingLevel" : "Student",
"abbreviation" : "NOTT",
"briefDesignDescription" : "Continuous vs. nocturnal oxygen in COPD",
"briefResultsDescription" : "Continuous oxygen reduces mortality in COPD with hypoxemia",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"statusUsableDate" : "2014-01-01"
},
{
"title" : "Controlled trial of budesonide+formoterol as needed for mild asthma",
"citation" : "Beasley R, et al. \"Controlled trial of budesonide+formoterol as needed for mild asthma\". The New England Journal of Medicine. 2019. 380(21):2020-2030.",
"pmid" : "31112386",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1901963",
"expansion" : "Novel Symbicort Turbuhaler Asthma Reliever Therapy",
"published" : "2019-05-23",
"pageName" : "Novel START",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1901963",
"statusUsableDate" : "2021-05-20",
"briefResultsDescription" : "ICS+LABA PRN with fewer overall, but more severe exacerbations",
"diseases" : "Asthma",
"briefDesignDescription" : "ICS+LABA PRN in mild asthma",
"abbreviation" : "Novel START",
"trainingLevel" : "resident",
"pageid" : 4142,
"timestamp" : "2021-05-31T17:57:36Z",
"subspecialties" : "Pulmonology"
},
{
"statusUsableDate" : "2013-02-01",
"diseases" : "Breast Cancer",
"briefResultsDescription" : "Sentinel lymph node biopsy is equally efficacious but has fewer side effects than ALND",
"trainingLevel" : "Student",
"briefDesignDescription" : "Sentinel LN biopsy in breast cancer",
"abbreviation" : "NSABP B-32",
"subspecialties" : "Oncology",
"timestamp" : "2018-09-06T17:17:20Z",
"pageid" : 1167,
"citation" : "Krag DN, et al. \"Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial\". Lancet Oncology. 2010. 11(10):927-933.",
"title" : "Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial",
"pdfurl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041644/pdf/nihms-250175.pdf",
"pmid" : "20863759",
"published" : "2010-10-01",
"expansion" : "National Surgical Adjuvant Breast and Bowel Project Trial B-32",
"fulltexturl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041644/",
"pageName" : "NSABP B-32"
},
{
"pdfurl" : "http://jnci.oxfordjournals.org/content/90/18/1371.full.pdf+html",
"pmid" : "9747868",
"title" : "Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study",
"citation" : "Fisher B, et al. \"Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study\". Journal of the National Cancer Institute. 1998. 90(18):1371-1388.",
"pageName" : "NSABP P-1",
"fulltexturl" : "http://jnci.oxfordjournals.org/content/90/18/1371.long",
"expansion" : "National Surgical Adjuvant Breast and Bowel Project, Prevention-1",
"published" : "1998-09-16",
"diseases" : "Breast Cancer",
"briefResultsDescription" : "Tamoxifen reduces breast cancer incidence by 48%",
"statusUsableDate" : "2012-10-01",
"timestamp" : "2017-12-03T22:37:56Z",
"pageid" : 1049,
"subspecialties" : "Oncology;Preventive Medicine",
"abbreviation" : "NSABP P-1",
"briefDesignDescription" : "Tamoxifen in breast cancer prevention",
"trainingLevel" : "resident"
},
{
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
"briefResultsDescription" : "Fondaparinux is non-inferior to enoxaparin in NSTE-ACS",
"statusUsableDate" : "2018-04-27",
"subspecialties" : "Cardiology",
"timestamp" : "2018-04-26T20:18:28Z",
"pageid" : 2484,
"trainingLevel" : "intern",
"briefDesignDescription" : "Fondaparinux vs. enoxaparin in NSTE-ACS",
"abbreviation" : "OASIS-5",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa055443",
"pmid" : "16537663",
"citation" : "Yusuf S, et al. \"Comparison of fondaparinux and enoxaparin in acute coronary syndromes\". The New England Journal of Medicine. 2006. 354(14):1464-1476.",
"title" : "Comparison of fondaparinux and enoxaparin in acute coronary syndromes",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa055443",
"pageName" : "OASIS-5",
"expansion" : "Fifth Organization to Assess Strategies in Acute Ischemic Syndromes",
"published" : "2006-04-06"
},
{
"statusUsableDate" : "2016-06-01",
"briefResultsDescription" : "PCI+OMT no better than OMT 3-28 days after MI",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"trainingLevel" : "Intern",
"briefDesignDescription" : "PCI+OMT vs. OMT 3-28 days after MI",
"abbreviation" : "OAT",
"subspecialties" : "Cardiology",
"pageid" : 2676,
"timestamp" : "2020-09-14T19:27:00Z",
"citation" : "Hochman J.S., et al. \"Coronary Intervention for Persistent Occlusion after Myocardial Infarction\". The New England Journal of Medicine. 2006. 355(23):2395-2407.",
"title" : "Coronary Intervention for Persistent Occlusion after Myocardial Infarction",
"pmid" : "17105759",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa066139",
"expansion" : "Occluded Artery Trial",
"published" : "2006-12-07",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa066139",
"pageName" : "OAT"
},
{
"diseases" : "Hyperlipidemia",
"briefResultsDescription" : "Alirocumab lowers LDL, reduces non-fatal MI",
"statusUsableDate" : "2015-09-01",
"timestamp" : "2017-12-14T19:48:32Z",
"pageid" : 2423,
"subspecialties" : "Cardiology",
"abbreviation" : "ODYSSEY LONG TERM",
"briefDesignDescription" : "PCSK9 inhibitor alirocumab for HLD",
"trainingLevel" : "Student",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501031",
"pmid" : "25773378",
"title" : "Efficacy and safety of alirocumab in reducing lipids and cardiovascular events",
"citation" : "Robinson JG, et al. \"Efficacy and safety of alirocumab in reducing lipids and cardiovascular events\". The New England Journal of Medicine. 2015. 372(16):1489-1499.",
"pageName" : "ODYSSEY LONG TERM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501031",
"published" : "2015-04-16",
"expansion" : "Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not\nAdequately Controlled with Their Lipid Modifying Therapy"
},
{
"diseases" : "Gastrointestinal Hemorrhage",
"briefResultsDescription" : "IV omeprazole reduced 30-day rebleeding",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Gastroenterology",
"timestamp" : "2016-04-01T23:27:21Z",
"pageid" : 247,
"trainingLevel" : "Resident",
"abbreviation" : null,
"briefDesignDescription" : "IV PPI for GI bleeds",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200008033430501",
"pmid" : "10922420",
"citation" : "Lau JYW, et al. \"Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcer\". The New England Journal of Medicine. 2000. 343(5):310-316.",
"title" : "Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcer",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200008033430501",
"pageName" : "Omeprazole in Peptic Ulcer Bleeding",
"expansion" : null,
"published" : "2000-08-03"
},
{
"briefResultsDescription" : "No difference in CV complications, combination ACE-inhibitor and ARB poorly tolerated",
"diseases" : "Cardiovascular Disease;Diabetes Mellitus;Stroke",
"statusUsableDate" : "2014-05-01",
"pageid" : 1776,
"timestamp" : "2017-12-03T22:38:00Z",
"subspecialties" : "Cardiology;Nephrology;Endocrinology",
"briefDesignDescription" : "Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM",
"abbreviation" : "ONTARGET",
"trainingLevel" : "Resident",
"pmid" : "18378520",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801317",
"title" : "Telmisartan, ramipril, or both in patients at high risk for vascular events",
"citation" : "Yusuf S, et al. \"Telmisartan, ramipril, or both in patients at high risk for vascular events\". The New England Journal of Medicine. 2008. 358(15):1547-1559.",
"pageName" : "ONTARGET",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801317",
"published" : "2008-04-10",
"expansion" : "Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial"
},
{
"trainingLevel" : "Student",
"briefDesignDescription" : "LAA closure vs. anticoagulation in AF",
"abbreviation" : "OPTION",
"subspecialties" : "Cardiology",
"timestamp" : "2025-05-16T15:04:11Z",
"pageid" : 5693,
"statusUsableDate" : "2025-04-20",
"diseases" : "Atrial Fibrillation",
"briefResultsDescription" : "LAA closure non-inferior or superior for AF outcomes vs. anticoagulation",
"expansion" : "cOmParison of anTIcoagulation with left atrial appendage clOsure after atrial fibrillation ablatioN",
"published" : "2025-04-03",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2408308",
"pageName" : "OPTION",
"citation" : "Wazni OM, et al. \"Left atrial appendage closure after ablation for atrial fibrillation\". The New England Journal of Medicine. 2025. 392(13):1277-1287.",
"title" : "Left atrial appendage closure after ablation for atrial fibrillation",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2408308",
"pmid" : "39555822"
},
{
"subspecialties" : "Cardiology;Neurology",
"pageid" : 1769,
"timestamp" : "2019-04-23T20:57:22Z",
"trainingLevel" : "Fellow",
"abbreviation" : "ORBIT-AF",
"briefDesignDescription" : "ASA/warfarin vs. warfarin in AF",
"briefResultsDescription" : "ASA/warfarin associated with more bleeding, fewer CV events",
"diseases" : "Atrial Fibrillation;Stroke",
"statusUsableDate" : "2014-06-01",
"fulltexturl" : "http://circ.ahajournals.org/content/128/7/721.long",
"pageName" : "ORBIT-AF",
"published" : "2013-08-13",
"expansion" : "Outcomes Registry for Better Informed Treatment of Atrial Fibrillation",
"pmid" : "23861512",
"pdfurl" : "http://circ.ahajournals.org/content/128/7/721.full.pdf",
"citation" : "Steinberg BA, et al. \"Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry\". Circulation. 2013. 128(7):721-8.",
"title" : "Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry"
},
{
"subspecialties" : "Cardiology",
"timestamp" : "2018-03-08T17:42:17Z",
"pageid" : 3499,
"trainingLevel" : "Resident",
"briefDesignDescription" : "PCI vs. medical therapy in stable angina",
"abbreviation" : "ORBITA",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "PCI not superior to medical therapy in stable angina",
"statusUsableDate" : "2017-12-14",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32714-9/fulltext",
"pageName" : "ORBITA",
"published" : "2017-11-02",
"expansion" : "Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(17)32714-9.pdf",
"pmid" : "29103656",
"citation" : "Al-Lamee R, et al. \"Percutaneous coronary intervention in stable angina\". Lancet. 2017. epub 2017-11-02:1-11.",
"title" : "Percutaneous coronary intervention in stable angina"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1203859",
"pmid" : "22686415",
"citation" : "Bosch J, et al. \"n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia\". The New England Journal of Medicine. 2012. 367(4):309-318.",
"title" : "n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1203859",
"pageName" : "ORIGIN n-3 Fatty Acids",
"expansion" : "Investigators in the outcome Reduction with an Initial Glargine Intervention",
"published" : "2012-07-26",
"diseases" : "Cardiovascular Disease;Coronary Artery Disease;Stroke",
"briefResultsDescription" : "n-3 fatty acids don't reduce CVD",
"statusUsableDate" : "2015-02-01",
"subspecialties" : "Cardiology;Neurology",
"timestamp" : "2017-12-03T22:38:03Z",
"pageid" : 2330,
"trainingLevel" : "Intern",
"abbreviation" : "ORIGIN n-3 Fatty Acids",
"briefDesignDescription" : "Fish oil for high-risk CVD"
},
{
"expansion" : "Oscillation for Acute Respiratory Distress Syndrome Treated Early",
"published" : "2013-02-28",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1215554",
"pageName" : "OSCILLATE",
"citation" : "Ferguson ND, et al. \"High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome\". The New England Journal of Medicine. 2013. 368(9):795-805.",
"title" : "High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1215554",
"pmid" : "23339639",
"trainingLevel" : "Resident",
"abbreviation" : "Oscillate",
"briefDesignDescription" : "High-frequency oscillatory vent in early ARDS",
"subspecialties" : "Critical Care;Pulmonology",
"timestamp" : "2017-12-03T22:38:05Z",
"pageid" : 1254,
"statusUsableDate" : "2013-09-01",
"diseases" : "Acute Respiratory Distress Syndrome",
"briefResultsDescription" : "High-frequency oscillatory vent may harm in early ARDS"
},
{
"published" : "2019-01-31",
"expansion" : "Oral versus Intravenous Antibiotics for Bone and Joint Infection",
"pageName" : "OVIVA",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1710926",
"title" : "Oral versus Intravenous Antibiotics for Bone and Joint Infection",
"citation" : "Li HK, et al. \"Oral versus Intravenous Antibiotics for Bone and Joint Infection\". The New England Journal of Medicine. 2019. 380(5):425-436.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1710926",
"pmid" : "30699315",
"briefDesignDescription" : "PO vs. IV antibiotics for bone/joint infection",
"abbreviation" : "OVIVA",
"trainingLevel" : "student",
"timestamp" : "2019-10-08T15:46:44Z",
"pageid" : 3542,
"subspecialties" : "Infectious Disease",
"statusUsableDate" : "2019-04-11",
"diseases" : "Osteomyelitis",
"briefResultsDescription" : "PO non-inferior to IV antibiotics for selected bone/joint infections"
},
{
"published" : "2017-09-08",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1709937",
"pageName" : "PACIFIC",
"citation" : "Antonia SJ et al. \"Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer\". The New England Journal of Medicine. 2017. 377(20):1919-1929.",
"title" : "Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer",
"pmid" : "28885881",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1709937",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Durvalumab vs. placebo as consolidation in NSCLC",
"abbreviation" : "PACIFIC",
"subspecialties" : "Oncology;Radiation Oncology",
"pageid" : 2969,
"timestamp" : "2025-06-05T18:03:47Z",
"statusUsableDate" : "2025-06-12",
"briefResultsDescription" : "Durvalumab increases PFS in NSCLC",
"diseases" : "Lung Cancer"
},
{
"pmid" : "37459086",
"pdfurl" : "https://jamanetwork.com/journals/jamainternalmedicine/articlepdf/2806976/jamainternal_copaescu_2023_oi_230043_1693517098.10841.pdf",
"title" : "Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy",
"citation" : "Copaescu AM, et al. \"Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy\". JAMA Internal Med. 2023. 183(9):944-952.",
"pageName" : "PALACE",
"fulltexturl" : "https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2806976",
"published" : "2023-09-01",
"expansion" : "The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge",
"briefResultsDescription" : "Penicillin 1-step rule out noninferior to 2-step",
"diseases" : "Penicillin Allergy",
"statusUsableDate" : "2025-01-29",
"pageid" : 5406,
"timestamp" : "2025-01-30T20:34:51Z",
"subspecialties" : "Infectious Disease",
"abbreviation" : "PALACE",
"briefDesignDescription" : "Penicillin allergy rule-out",
"trainingLevel" : "student"
},
{
"timestamp" : "2019-08-31T19:06:09Z",
"pageid" : 398,
"subspecialties" : "Surgery;Gastroenterology",
"briefDesignDescription" : "Step-up approach to pancreatitis",
"abbreviation" : "PANTER",
"trainingLevel" : "Fellow",
"diseases" : "Pancreatitis",
"briefResultsDescription" : "Step-up approach reduces major complications and death",
"statusUsableDate" : "2012-03-01",
"pageName" : "PANTER",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0908821",
"published" : "2010-04-22",
"expansion" : "Minimally Invasive Step Up Approach versus Maximal Necrosectomy in Patients with Acute Necrotising Pancreatitis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0908821",
"pmid" : "20410514",
"title" : "A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis",
"citation" : "van Santvoort HC, et al. \"A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis\". The New England Journal of Medicine. 2010. 362(16):1491-502."
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409077",
"pmid" : "25176015",
"title" : "Angiotensin-neprilysin inhibition versus enalapril in heart failure",
"citation" : "McMurray JJV, et al. \"Angiotensin-neprilysin inhibition versus enalapril in heart failure\". The New England Journal of Medicine. 2014. 371(11):993-1004.",
"pageName" : "PARADIGM-HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409077",
"expansion" : "Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure",
"published" : "2014-08-30",
"diseases" : "Heart Failure",
"briefResultsDescription" : "ARNI reduces mortality in HFrEF",
"statusUsableDate" : "2014-09-01",
"timestamp" : "2021-07-28T06:20:24Z",
"pageid" : 2163,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "ARNI vs. enalapril in HFrEF",
"abbreviation" : "PARADIGM-HF",
"trainingLevel" : "Resident"
},
{
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1908655",
"pmid" : "32187481",
"title" : "Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction",
"citation" : "Solomon SD, et al. \"Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction\". The New England Journal of Medicine. 2019. 381(17):1609-1620.",
"pageName" : "PARAGON-HF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1908655",
"published" : "2019-10-24",
"expansion" : "Prospective Comparison of ARNI Global Outcomes in HF with Preserved Ejection Fraction",
"diseases" : "Heart Failure",
"briefResultsDescription" : "No benefit from ARNI in HFpEF",
"statusUsableDate" : "2020-07-02",
"timestamp" : "2020-07-02T17:06:36Z",
"pageid" : 4184,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "ARNI in symptomatic HFpEF",
"abbreviation" : "PARAGON-HF",
"trainingLevel" : "Resident"
},
{
"pdfurl" : "http://jco.ascopubs.org/content/31/23/2895.full.pdf",
"pmid" : "23835707",
"title" : "PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer",
"citation" : "Paz-Ares LG, et al. \"PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer\". Journal of Clinical Oncology. 2013. 31(23):2895-902.",
"pageName" : "PARAMOUNT",
"fulltexturl" : "http://jco.ascopubs.org/content/31/23/2895.long",
"expansion" : "",
"published" : "2013-08-10",
"diseases" : "Lung Cancer",
"briefResultsDescription" : "Maintenance pemetrexed improves PFS and OS following induction with cisplatin/pemetrexed",
"statusUsableDate" : "2014-01-01",
"timestamp" : "2017-12-03T22:38:08Z",
"pageid" : 1606,
"subspecialties" : "Oncology",
"briefDesignDescription" : "Maintenance pemetrexed in lung cancer",
"abbreviation" : "PARAMOUNT",
"trainingLevel" : "Fellow"
},
{
"title" : "Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients",
"citation" : "Leon MB, et al. \"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients\". The New England Journal of Medicine. 2016. 374(17):1609-20.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1514616",
"pmid" : "27040324",
"expansion" : "Placement of Aortic Transcatheter Valves, Cohort A",
"published" : "2016-04-28",
"pageName" : "PARTNER 2",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1514616",
"statusUsableDate" : "2016-05-01",
"diseases" : "Aortic Stenosis",
"briefResultsDescription" : "TAVI noninferior to surgical AVR in intermediate-risk surgical candidates",
"abbreviation" : "PARTNER 2",
"briefDesignDescription" : "TAVI for AS in intermediate-risk surgical candidates",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:38:09Z",
"pageid" : 2753,
"subspecialties" : "Cardiology"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "TAVR for AS in low-risk surgical candidates",
"abbreviation" : "PARTNER 3",
"subspecialties" : "Cardiology",
"timestamp" : "2019-10-17T18:34:54Z",
"pageid" : 3949,
"statusUsableDate" : "2019-10-16",
"diseases" : "Aortic Stenosis",
"briefResultsDescription" : "TAVR superior to surgical AVR in low-risk surgical candidates",
"expansion" : "Placement of Aortic Transcatheter Valves 3",
"published" : "2019-03-16",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1814052",
"pageName" : "PARTNER 3",
"citation" : "Mack MJ, et al. \"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients\". The New England Journal of Medicine. 2019. 380(18):1695-1705.",
"title" : "Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1814052",
"pmid" : "30883058"
},
{
"pageName" : "PARTNER A",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1103510",
"published" : "2011-06-09",
"expansion" : "Placement of Aortic Transcatheter Valves, Cohort A",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1103510",
"pmid" : "21639811",
"title" : "Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients",
"citation" : "Smith CR, et al. \"Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients\". The New England Journal of Medicine. 2011. 364(23):2187-98.",
"timestamp" : "2017-12-03T22:38:10Z",
"pageid" : 2741,
"subspecialties" : "Cardiology",
"abbreviation" : "PARTNER A",
"briefDesignDescription" : "TAVI for AS in high-risk surgical candidates",
"trainingLevel" : "Intern",
"diseases" : "Aortic Stenosis",
"briefResultsDescription" : "TAVI noninferior to surgical AVR in high-risk surgical candidates",
"statusUsableDate" : "2016-05-01"
},
{
"pmid" : "20961243",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1008232",
"citation" : "Leon MB, et al. \"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery\". The New England Journal of Medicine. 2010. 363(17):1597-1607.",
"title" : "Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1008232",
"pageName" : "PARTNER B",
"expansion" : "Placement of Aortic Transcatheter Valves, Cohort B",
"published" : "2010-10-21",
"briefResultsDescription" : "TAVI reduces all-cause mortality ± rehospitalization, increased stroke",
"diseases" : "Aortic Stenosis",
"statusUsableDate" : "2013-12-01",
"subspecialties" : "Cardiology",
"pageid" : 1674,
"timestamp" : "2017-12-03T22:38:12Z",
"trainingLevel" : "Intern",
"abbreviation" : "PARTNER B",
"briefDesignDescription" : "TAVI for AS in poor surgical candidates"
},
{
"pageName" : "PATHWAY-2",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(15)00257-3",
"expansion" : "Prevention and Treatment of Hypertension with Algorithm-Based Therapy (PATHWAY)",
"published" : "2015-11-21",
"pdfurl" : "http://bit.ly/pathway-2-pdf",
"pmid" : "26414968",
"title" : "Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial",
"citation" : "Williams B, et al. \"Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial\". The Lancet. 2015. 386(10008):2059-2068.",
"timestamp" : "2021-02-12T16:58:50Z",
"pageid" : 2733,
"subspecialties" : "Cardiology;Nephrology;Preventive Medicine",
"briefDesignDescription" : "Spironolactone for resistant HTN",
"abbreviation" : "PATHWAY-2",
"trainingLevel" : "Resident",
"diseases" : "Hypertension",
"briefResultsDescription" : "Spironolactone improved BP control compared to placebo, doxazosin, or bisoprolol",
"statusUsableDate" : "2021-02-11"
},
{
"briefResultsDescription" : "Holding DOAC by this protocol has little bleeding and events",
"diseases" : "Atrial Fibrillation",
"statusUsableDate" : "2021-04-29",
"subspecialties" : "Cardiology",
"pageid" : 4421,
"timestamp" : "2021-05-12T12:54:33Z",
"trainingLevel" : "fellow",
"briefDesignDescription" : "Perioperative DOAC holding protocols in AF",
"abbreviation" : "PAUSE",
"pmid" : "31380891",
"pdfurl" : "",
"citation" : "Douketis JD, et al. \"Perioperative management of patients with atrial fibrillation receiving a direct oral anticoagulant\". JAMA Internal Medicine. 2019. 179(11):1469-1478.",
"title" : "Perioperative management of patients with atrial fibrillation receiving a direct oral anticoagulant",
"fulltexturl" : "https://doi.org/10.1001/jamainternmed.2019.2431",
"pageName" : "PAUSE",
"published" : "2019-08-05",
"expansion" : "Perioperative Anticoagulation Use for Surgery Evaluation"
},
{
"title" : "The influence of finasteride on the development of prostate cancer",
"citation" : "Thompson IM, et al. \"The influence of finasteride on the development of prostate cancer\". The New England Journal of Medicine. 2003. 349(3):215-224.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030660",
"pmid" : "12824459",
"published" : "2003-07-13",
"expansion" : "Prostate Cancer Prevention Trial",
"pageName" : "PCPT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030660",
"statusUsableDate" : "2014-02-01",
"diseases" : "Prostate Cancer",
"briefResultsDescription" : "Finasteride reduces all-grade prostate cancer risk, increases high-grade disease",
"briefDesignDescription" : "Finasteride for prostate cancer prophylaxis",
"abbreviation" : "PCPT",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:38:13Z",
"pageid" : 1786,
"subspecialties" : "Urology;Oncology"
},
{
"trainingLevel" : "Intern",
"abbreviation" : "PEGASUS-TIMI 54",
"briefDesignDescription" : "Extended ticagrelor+ASA after MI",
"subspecialties" : "Cardiology",
"timestamp" : "2020-09-14T19:27:22Z",
"pageid" : 2469,
"statusUsableDate" : "2015-12-01",
"diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
"briefResultsDescription" : "Extended ticagrelor+ASA reduces CVD events after MI",
"expansion" : "",
"published" : "2015-05-07",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500857",
"pageName" : "PEGASUS-TIMI 54",
"citation" : "Bonaca MP, et al. \"Long-term use of ticagrelor in patients with prior myocardial infarction\". The New England Journal of Medicine. 2015. 372(19):1791-1800.",
"title" : "Long-term use of ticagrelor in patients with prior myocardial infarction",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500857",
"pmid" : "25773268"
},
{
"trainingLevel" : "resident",
"abbreviation" : "PEITHO",
"briefDesignDescription" : "tPA for submassive PE",
"subspecialties" : "Critical Care;Pulmonology;Hematology",
"timestamp" : "2021-06-08T19:31:33Z",
"pageid" : 1778,
"statusUsableDate" : "2014-04-01",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"briefResultsDescription" : "tPA reduces hemodynamic decomp, not mortality, also increases bleeding in submassive PE",
"expansion" : "Pulmonary Embolism Thrombolysis trial",
"published" : "2014-04-10",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1302097",
"pageName" : "PEITHO",
"citation" : "Meyer G, et al. \"Fibrinolysis for patients with intermediate-risk pulmonary embolism\". The New England Journal of Medicine. 2014. 370(15):1402-1411.",
"title" : "Fibrinolysis for patients with intermediate-risk pulmonary embolism",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302097",
"pmid" : "24716681"
},
{
"expansion" : "",
"published" : "2000-12-20",
"pageName" : "Pentoxifylline in Severe Alcoholic Hepatitis",
"fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(00)51183-4/fulltext",
"title" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial",
"citation" : "Akriviadis E, et al. \"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial\". Gastroenterology. 2000. 119(6):1637-48.",
"pmid" : "11113085",
"pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0016-5085/PIIS0016508500511834.pdf",
"abbreviation" : "",
"briefDesignDescription" : "Pentoxifylline in alcoholic hepatitis",
"trainingLevel" : "Resident",
"pageid" : 53,
"timestamp" : "2015-07-06T21:57:52Z",
"subspecialties" : "Gastroenterology",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis",
"diseases" : "Alcoholic Hepatitis"
},
{
"statusUsableDate" : "2021-05-20",
"diseases" : "Pulmonary Embolism",
"briefResultsDescription" : "Low probability of PE mortality with low PERC probability",
"trainingLevel" : "Resident",
"abbreviation" : "PERC",
"briefDesignDescription" : "PE rule-out criteria",
"subspecialties" : "Emergency Medicine;Pulmonology;Hematology",
"timestamp" : "2021-05-31T17:58:55Z",
"pageid" : 2657,
"citation" : "Kline JA, et al. \"Prospective multicenter evaluation of the pulmonary embolism rule-out criteria\". J Thromb Haemost. 2008. 6(5):772-780.",
"title" : "Prospective multicenter evaluation of the pulmonary embolism rule-out criteria",
"pdfurl" : "http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2008.02944.x/epdf",
"pmid" : "18318689",
"published" : "2008-05-06",
"expansion" : "Pulmonary Embolism Rule-Out Criteria",
"fulltexturl" : "http://dx.doi.org/10.1111/j.1538-7836.2008.02944.x",
"pageName" : "PERC"
},
{
"abbreviation" : "PESIT",
"briefDesignDescription" : "Prevalence of PE in syncope",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:38:18Z",
"pageid" : 2843,
"subspecialties" : "Hematology",
"statusUsableDate" : "2016-11-01",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism;Syncope",
"briefResultsDescription" : "PE found in 1 of 6 patients with syncope",
"expansion" : "Pulmonary Embolism in Syncope Italian Trial",
"published" : "2016-10-20",
"pageName" : "PESIT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602172",
"title" : "Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope",
"citation" : "Prandoni P, et al. \"Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope\". The New England Journal of Medicine. 2016. 375(16):1524-31.",
"pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602172",
"pmid" : "27797317"
},
{
"title" : "Prevention of bleeding in patients with AF undergoing PCI",
"citation" : "Gibson CM, et al. \"Prevention of bleeding in patients with AF undergoing PCI\". The New England Journal of Medicine. 2016. epub 2016-11-14:1-12.",
"pmid" : "27959713",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611594",
"published" : "2016-11-14",
"expansion" : "Open-Label, Randomized, Controlled, Multicenter Study Exploring Two Treatment Strategies of Rivaroxaban and a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy in Subjects with AF who Undergo Percutaneous Coronary Intervention",
"pageName" : "PIONEER AF-PCI",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611594",
"statusUsableDate" : "2016-12-01",
"briefResultsDescription" : "Rivaroxaban with lower bleeding",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"briefDesignDescription" : "DOAC, VKA, antiplatelets after PCI with stent",
"abbreviation" : "PIONEER AF-PCI",
"trainingLevel" : "Resident",
"pageid" : 2861,
"timestamp" : "2017-12-03T22:38:19Z",
"subspecialties" : "Cardiology"
},
{
"statusUsableDate" : "2019-01-31",
"briefResultsDescription" : "Sacubitril-valsartan reduces NT-ProBNP",
"diseases" : "Heart Failure",
"abbreviation" : "PIONEER-HF",
"briefDesignDescription" : "ARNI started in ADHF hospitalization",
"trainingLevel" : "Student",
"pageid" : 3740,
"timestamp" : "2019-02-14T22:49:17Z",
"subspecialties" : "Cardiology",
"title" : "Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure",
"citation" : "Velazquez EJ, et al. \"Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure\". The New England Journal of Medicine. 2018. ePub 2018-11-11:1-10.",
"pmid" : "30415601",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812851",
"expansion" : "comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode",
"published" : "2018-11-11",
"pageName" : "PIONEER-HF",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812851"
},
{
"briefResultsDescription" : "CT sensitive and specific in detecting acute PE",
"diseases" : "Pulmonary Embolism;Venous Thromboembolism",
"statusUsableDate" : "2012-03-01",
"pageid" : 161,
"timestamp" : "2016-04-05T13:46:19Z",
"subspecialties" : "Pulmonology;Hematology",
"abbreviation" : "PIOPED II",
"briefDesignDescription" : "Accuracy of CT for PE",
"trainingLevel" : "MedicalStudent",
"pmid" : "16738268",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052367#t",
"title" : "Multidetector Computed Tomography for Acute Pulmonary Embolism",
"citation" : "Stein PD, et al. \"Multidetector Computed Tomography for Acute Pulmonary Embolism\". The New England Journal of Medicine. 2006. 354(22):2317-2327.",
"pageName" : "PIOPED II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052367#t",
"expansion" : "Prospective Investigation of Pulmonary Embolism Diagnosis II",
"published" : "2006-06-01"
},
{
"pmid" : "23932219",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673613612180.pdf",
"citation" : "Allen SJ, et al. \"Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial\". The Lancet. 2013. 382(9900):1249-1257.",
"title" : "Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2961218-0/abstract",
"pageName" : "PLACIDE",
"published" : "2013-10-12",
"expansion" : "",
"briefResultsDescription" : "Probiotics do not reduce diarrhea including C. diff with antibiotics",
"diseases" : "Clostridium difficile",
"statusUsableDate" : "2014-05-01",
"subspecialties" : "Gastroenterology;Infectious Disease;Preventive Medicine",
"pageid" : 1770,
"timestamp" : "2019-12-20T10:41:43Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Probiotics to prevent CDAD",
"abbreviation" : "PLACIDE"
},
{
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease",
"briefResultsDescription" : "Ticagrelor reduces mortality, increases bleeding",
"statusUsableDate" : "2013-09-01",
"timestamp" : "2017-12-03T22:38:22Z",
"pageid" : 1629,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Ticagrelor vs. clopidogrel in ACS",
"abbreviation" : "PLATO",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0904327",
"pmid" : "19717846",
"title" : "Ticagrelor versus clopidogrel in patients with acute coronary syndromes",
"citation" : "Wallentin L, et al. \"Ticagrelor versus clopidogrel in patients with acute coronary syndromes\". The New England Journal of Medicine. 2009. 361(11):1045-1057.",
"pageName" : "PLATO",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0904327",
"expansion" : "Platelet Inhibition and Patient Outcomes",
"published" : "2009-09-10"
},
{
"pageid" : 118,
"timestamp" : "2012-05-07T02:36:42Z",
"subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
"briefDesignDescription" : "8 vs. 15 days of antibiotics in VAP",
"abbreviation" : "PneumA",
"trainingLevel" : "Intern",
"briefResultsDescription" : "8 days of antibiotics are equivalent to 15 days",
"diseases" : "Pneumonia",
"statusUsableDate" : "2012-03-01",
"pageName" : "PneumA",
"fulltexturl" : "http://jama.ama-assn.org/content/290/19/2588.long",
"published" : "2003-11-19",
"expansion" : "",
"pmid" : "14625336",
"pdfurl" : "http://jama.ama-assn.org/content/290/19/2588.full.pdf",
"title" : "Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial",
"citation" : "Chastre J. \"Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial\". Journal of the American Medical Association. 2003. 290(19):2588-98."
},
{
"statusUsableDate" : "2019-04-10",
"diseases" : "Endocarditis",
"briefResultsDescription" : "PO abx after IV abx non-inferior to IV abx only",
"briefDesignDescription" : "PO abx after 10d IV abx for left-sided endocarditis",
"abbreviation" : "POET",
"trainingLevel" : "Student",
"timestamp" : "2019-08-26T14:27:41Z",
"pageid" : 3722,
"subspecialties" : "Infectious Disease",
"title" : "Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis",
"citation" : "Iversen K, et al. \"Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis\". The New England Journal of Medicine. 2019. 380(5):415-424.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1808312",
"pmid" : "30152252",
"expansion" : "Partial Oral Treatment of Endocarditis",
"published" : "2019-01-31",
"pageName" : "POET",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1808312"
},
{
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800410",
"pageName" : "POINT",
"expansion" : "Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial",
"published" : "2018-05-16",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800410",
"pmid" : "29766750",
"citation" : "Johnston SC, et al. \"Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA\". The New England Journal of Medicine. 2018. 379(3):215-225.",
"title" : "Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA",
"subspecialties" : "Neurology",
"timestamp" : "2018-11-07T06:34:44Z",
"pageid" : 3659,
"trainingLevel" : "Resident",
"briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin in stroke/TIA",
"abbreviation" : "POINT",
"diseases" : "Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "Aspirin/clopidogrel reduces stroke recurrence, increases bleeding compared to aspirin",
"statusUsableDate" : "2018-08-09"
},
{
"diseases" : "Cardiac Risk Assessment;Coronary Artery Disease",
"briefResultsDescription" : "Perioperative metoprolol reduces MI risk but increases risk of mortality and stroke",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2024-10-23T13:45:05Z",
"pageid" : 173,
"subspecialties" : "Surgery;Cardiology",
"briefDesignDescription" : "Perioperative metoprolol",
"abbreviation" : "POISE",
"trainingLevel" : "Intern",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673608606017.pdf",
"pmid" : "18479744",
"title" : "Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial",
"citation" : "Devereaux PJ, et al. \"Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial\". The Lancet. 2008. 371(9627):1839-1847.",
"pageName" : "POISE",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)60601-7/fulltext",
"expansion" : "PeriOperative ISchemic Evaluation",
"published" : "2008-05-31"
},
{
"briefResultsDescription" : "Perioperative ASA doesn't modify MI rates but increases major bleeding",
"diseases" : "Cardiac Risk Assessment",
"statusUsableDate" : "2014-04-01",
"pageid" : 1777,
"timestamp" : "2017-12-03T22:38:24Z",
"subspecialties" : "Cardiology;Surgery",
"abbreviation" : "POISE-2 ASA",
"briefDesignDescription" : "Perioperative ASA",
"trainingLevel" : "Intern",
"pmid" : "24679062",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1401105",
"title" : "Aspirin in patients undergoing noncardiac surgery",
"citation" : "Devereaux PJ, et al. \"Aspirin in patients undergoing noncardiac surgery\". The New England Journal of Medicine. 2014. 370(16):1494-1503.",
"pageName" : "POISE-2 ASA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1401105",
"published" : "2014-03-31",
"expansion" : "Perioperative ischemic evaluation 2 aspirin arm"
},
{
"pageName" : "POP-UP",
"fulltexturl" : "https://dx.doi.org/10.1097/CCM.0000000000001819",
"published" : "2016-10-01",
"expansion" : "Pantoprazole or Placebo for Stress Ulcer Prophylaxis",
"pdfurl" : "http://ovidsp.tx.ovid.com/sp-3.26.1a/ovidweb.cgi?&S",
"pmid" : "27635481",
"title" : "Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study",
"citation" : "Selvanderan SP, et al. \"Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study\". Critical Care Medicine. 2016. 44(10):1842-1850.",
"timestamp" : "2017-12-03T22:38:25Z",
"pageid" : 2866,
"subspecialties" : "Critical Care",
"abbreviation" : "POP-UP",
"briefDesignDescription" : "PPIs for stress ulcer prophylaxis",
"trainingLevel" : "Resident",
"diseases" : "Stress Ulcer",
"briefResultsDescription" : "PPIs do not reduce risk of stress ulcer bleeding in enterally fed patients",
"statusUsableDate" : "2017-09-01"
},
{
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1915932",
"pageName" : "PRAETORIAN",
"expansion" : "Prospective Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy",
"published" : "2020-08-06",
"pmid" : "32757521",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915932",
"citation" : "Knops RE, et al. \"Subcutaneous or Transvenous Defibrillator Therapy\". The New England Journal of Medicine. 2020. 383(6):526-36.",
"title" : "Subcutaneous or Transvenous Defibrillator Therapy",
"subspecialties" : "Cardiology",
"pageid" : 4394,
"timestamp" : "2021-01-11T18:51:08Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Transvenous vs. subq ICD to prevent sudden cardiac death",
"abbreviation" : "PRAETORIAN",
"briefResultsDescription" : "Subcutaneous ICD non-inferior to transvenous ICD",
"diseases" : "Unstable Arrhythmia",
"statusUsableDate" : "2021-01-08"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305520",
"pageName" : "PRAMI",
"published" : "2013-09-19",
"expansion" : "Preventative Angioplasty in Acute Myocardial Infarction",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1305520",
"pmid" : "23991625",
"citation" : "Wald DS, et al. \"Randomized trial of preventative angioplasty in myocardial infarction\". The New England Journal of Medicine. 2013. 369(12):1115-1123.",
"title" : "Randomized trial of preventative angioplasty in myocardial infarction",
"subspecialties" : "Cardiology",
"timestamp" : "2018-11-18T20:26:21Z",
"pageid" : 1748,
"trainingLevel" : "Resident",
"briefDesignDescription" : "PCI to high-risk non-infarct arteries in STEMI",
"abbreviation" : "PRAMI",
"diseases" : "Myocardial Infarction",
"briefResultsDescription" : "PCI to high-risk non infarct arteries in STEMI improves CV outcomes",
"statusUsableDate" : "2013-11-01"
},
{
"statusUsableDate" : "2017-03-01",
"diseases" : "Coronary Artery Disease;Rheumatoid Arthritis;Osteoarthritis;Stroke",
"briefResultsDescription" : "Celecoxib noninferior to ibuprofen or naproxen with regard to CV safety",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Celecoxib, naproxen, or ibuprofen for CV safety in arthritis",
"abbreviation" : "PRECISION",
"subspecialties" : "Cardiology;Rheumatology;Neurology",
"timestamp" : "2018-06-01T20:19:38Z",
"pageid" : 2888,
"citation" : "Nissen SE, et al. \"Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis\". The New England Journal of Medicine. 2016. 375(26):2519-2529.",
"title" : "Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611593",
"pmid" : "27959716",
"expansion" : "Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen",
"published" : "2016-12-29",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611593",
"pageName" : "PRECISION"
},
{
"timestamp" : "2018-06-14T20:17:40Z",
"pageid" : 1247,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Mediterranean diet in CVD prevention",
"abbreviation" : "PREDIMED",
"trainingLevel" : "Student",
"diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
"briefResultsDescription" : "Mediterranean diet reduces composite rate of MI/CVA/CV death",
"statusUsableDate" : "2013-06-01",
"pageName" : "PREDIMED",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200303",
"expansion" : "Prevención con Dieta Mediterránea",
"published" : "2013-02-25",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200303",
"pmid" : "23432189",
"title" : "Primary prevention of cardiovascular disease with a mediterranean diet",
"citation" : "Estruch R, et al. \"Primary prevention of cardiovascular disease with a mediterranean diet\". The New England Journal of Medicine. 2013. 368(14):1279-1290."
},
{
"expansion" : "",
"published" : "1992-02-20",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199202203260802",
"pageName" : "Prednisolone in Severe Alcoholic Hepatitis",
"citation" : "Ramond MJ, et al. \"A randomized trial of prednisolone in patients with severe alcoholic hepatitis\". The New England Journal of Medicine. 1992. 362(8):507-512.",
"title" : "A randomized trial of prednisolone in patients with severe alcoholic hepatitis",
"pmid" : "1531090",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199202203260802",
"trainingLevel" : "Intern",
"abbreviation" : "",
"briefDesignDescription" : "Prednisolone vs. placebo in alcoholic hepatitis",
"subspecialties" : "Gastroenterology",
"pageid" : 1113,
"timestamp" : "2015-07-06T21:57:28Z",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Prednisolone improves short-term survival",
"diseases" : "Alcoholic Hepatitis"
},
{
"pmid" : "9459643",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199802123380701",
"title" : "A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis",
"citation" : "Decousus H, et al. \"A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis\". The New England Journal of Medicine. 1998. 338(7):409-416.",
"pageName" : "PREPIC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199802123380701",
"published" : "1998-02-12",
"expansion" : "Prévention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group",
"briefResultsDescription" : "IVC filters reduce future PE risk but increase DVT risk",
"diseases" : "Deep Vein Thrombosis;Venous Thromboembolism;Pulmonary Embolism",
"statusUsableDate" : "2016-03-01",
"pageid" : 2697,
"timestamp" : "2017-12-03T22:38:31Z",
"subspecialties" : "Pulmonology;Hematology;Interventional Radiology",
"abbreviation" : "PREPIC",
"briefDesignDescription" : "IVC filters for proximal DVT",
"trainingLevel" : "Resident"
},
{
"pageName" : "PREPIC 2",
"fulltexturl" : "http://bit.ly/1Jti6Ct",
"expansion" : "Prevention du Risque d'Embolie Pulmonaire par Interruption Cave 2",
"published" : "2015-04-28",
"pmid" : "25919526",
"pdfurl" : "http://bit.ly/1ONs0iA",
"title" : "Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial",
"citation" : "Mismetti P, et al. \"Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial\". The Journal of the American Medical Association. 2015. 313(16):1627-35.",
"pageid" : 2405,
"timestamp" : "2017-12-03T22:38:33Z",
"subspecialties" : "Hematology;Pulmonology;Interventional Radiology",
"briefDesignDescription" : "IVC filters for high-risk PE",
"abbreviation" : "PREPIC 2",
"trainingLevel" : "Intern",
"briefResultsDescription" : "IVC filters do not improve outcomes in acute high-risk PE",
"diseases" : "Venous Thromboembolism",
"statusUsableDate" : "2015-07-01"
},
{
"published" : "2014-07-08",
"expansion" : "Prospective Randomized Evaluation of the Watchman LAA Closure Device In Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy",
"pageName" : "PREVAIL",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(14)02341-9",
"title" : "Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial",
"citation" : "Holmes DR, et al. \"Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial\". Journal of the American College of Cardiology. 2014. 64(1):1-12.",
"pdfurl" : "https://www.sciencedirect.com/science/article/pii/S0735109714023419/pdfft?download",
"pmid" : "24998121",
"abbreviation" : "PREVAIL",
"briefDesignDescription" : "LAA closure vs. warfarin in AF",
"trainingLevel" : "Resident",
"timestamp" : "2021-07-30T04:27:31Z",
"pageid" : 3535,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2021-07-29",
"diseases" : "Atrial Fibrillation",
"briefResultsDescription" : "LAA noninferior to warfarin in AF"
},
{
"statusUsableDate" : "2012-08-01",
"diseases" : "Tuberculosis",
"briefResultsDescription" : "Rifapentine/isoniazid x3 months is noninferior to isoniazid x9 months",
"abbreviation" : "PREVENT TB",
"briefDesignDescription" : "Rifapentine/isoniazid in latent TB",
"trainingLevel" : "fellow",
"timestamp" : "2017-12-03T22:38:34Z",
"pageid" : 928,
"subspecialties" : "Infectious Disease",
"title" : "Three months of rifapentine and isoniazid for latent tuberculosis infection.",
"citation" : "Sterling TR, et al. \"Three months of rifapentine and isoniazid for latent tuberculosis infection.\". The New England Journal of Medicine. 2011. 365(23):2155-66.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1104875",
"pmid" : "22150035",
"expansion" : null,
"published" : "2011-12-08",
"pageName" : "PREVENT TB",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1104875"
},
{
"statusUsableDate" : "2014-03-01",
"briefResultsDescription" : "No difference for EGDT vs. standard protocol vs. usual care for septic shock",
"diseases" : "Sepsis",
"trainingLevel" : "Intern",
"abbreviation" : "ProCESS",
"briefDesignDescription" : "EGDT in septic shock",
"subspecialties" : "Critical Care",
"pageid" : 1782,
"timestamp" : "2017-12-03T22:38:46Z",
"citation" : "Angus DC, et al. \"A randomized trial of protocol-based care for early septic shock\". The New England Journal of Medicine. 2014. 370(10):1683-1693.",
"title" : "A randomized trial of protocol-based care for early septic shock",
"pmid" : "24635773",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1401602",
"published" : "2014-05-01",
"expansion" : "Protocolized Care for Early Septic Shock",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1401602",
"pageName" : "ProCESS"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011923",
"pmid" : "21561347",
"title" : "FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer",
"citation" : "Conroy T, et al. \"FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer\". The New England Journal of Medicine. 2011. 364(19):1817-1825.",
"pageName" : "PRODIGE 4 ACCORD 11",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011923",
"published" : "2011-05-12",
"expansion" : "PRODIGE 4 Actions concertées dans les Cancers COloRectaux et Digestifs",
"diseases" : "Pancreatic Cancer",
"briefResultsDescription" : "FOLFIRINOX improves OS in metastatic pancreatic cancer compared to gemcitabine",
"statusUsableDate" : "2016-09-01",
"timestamp" : "2017-12-03T22:38:35Z",
"pageid" : 2819,
"subspecialties" : "Oncology",
"abbreviation" : "PRODIGE 4 ACCORD 11",
"briefDesignDescription" : "FOLFIRINOX in pancreatic cancer",
"trainingLevel" : "Resident"
},
{
"pmid" : "18753638",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805002",
"title" : "Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke",
"citation" : "Sacco RL, et al. \"Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke\". The New England Journal of Medicine. 2008. 359(12):1238-1251.",
"pageName" : "PRoFESS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805002",
"expansion" : "Prevention Regimen for Effectively Avoiding Second Strokes",
"published" : "2008-09-18",
"briefResultsDescription" : "Similar efficacy but less bleeding with clopidogrel",
"diseases" : "Stroke",
"statusUsableDate" : "2012-11-01",
"pageid" : 1082,
"timestamp" : "2017-12-03T22:38:44Z",
"subspecialties" : "Neurology",
"briefDesignDescription" : "ASA-dipyridamole vs. clopidogrel in stroke",
"abbreviation" : "PROFESS",
"trainingLevel" : "Resident"
},
{
"statusUsableDate" : "2023-01-21",
"diseases" : "Stroke;Hypertension",
"briefResultsDescription" : "Perindopril+indapamide lowers recurrent stroke risk among those with prior stroke",
"trainingLevel" : "Intern",
"briefDesignDescription" : "Perindopril±indapamide after stroke",
"abbreviation" : "PROGRESS",
"subspecialties" : "Neurology",
"timestamp" : "2023-07-20T03:15:45Z",
"pageid" : 2450,
"citation" : "PROGRESS Collaborative Group. \"Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack\". Lancet. 2001. 358(9287):1033–1041.",
"title" : "Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack",
"pdfurl" : "",
"pmid" : "11589932",
"published" : "2001-09-29",
"expansion" : "Protection Against Recurrent Stroke Study",
"fulltexturl" : "https://doi.org/10.1016/S0140-6736(01)06178-5",
"pageName" : "PROGRESS"
},
{
"statusUsableDate" : "2017-10-01",
"briefResultsDescription" : "Abnormal D-dimer predicts VTE recurrence",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"trainingLevel" : "Resident",
"briefDesignDescription" : "D-Dimer testing after VTE",
"abbreviation" : "PROLONG",
"subspecialties" : "Hematology",
"pageid" : 2967,
"timestamp" : "2017-12-03T22:38:37Z",
"citation" : "Palareti G, et al. \"d-Dimer Testing to Determine the Duration of Anticoagulation Therapy\". The New England Journal of Medicine. 2006. 355(17):1780-1789.",
"title" : "d-Dimer Testing to Determine the Duration of Anticoagulation Therapy",
"pmid" : "17065639",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa054444",
"published" : "2006-10-26",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa054444",
"pageName" : "PROLONG"
},
{
"statusUsableDate" : "2019-02-27",
"briefResultsDescription" : "Multicenter trial shows no benefit to EGDT in severe sepsis",
"diseases" : "Sepsis;Shock",
"abbreviation" : "ProMISe",
"briefDesignDescription" : "Multicenter EGDT trial in severe sepsis",
"trainingLevel" : "Resident",
"pageid" : 2385,
"timestamp" : "2019-02-28T18:12:36Z",
"subspecialties" : "Critical Care;Emergency Medicine",
"title" : "Trial of early, goal-directed resuscitation for septic shock",
"citation" : "Mouncey PR, et al. \"Trial of early, goal-directed resuscitation for septic shock\". The New England Journal of Medicine. 2015. 372(14):1301-1311.",
"pmid" : "25776532",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500896",
"published" : "2015-04-02",
"expansion" : "",
"pageName" : "ProMISe",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500896"
},
{
"statusUsableDate" : "2024-08-06",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Coronary CT no different from other modalities",
"trainingLevel" : "Resident",
"abbreviation" : "PROMISE",
"briefDesignDescription" : "Coronary CT for angina",
"subspecialties" : "Cardiology",
"timestamp" : "2025-09-04T17:15:40Z",
"pageid" : 3720,
"citation" : "Douglas PS, et al. \"Outcomes of anatomical versus functional testing for coronary artery disease\". The New England Journal of Medicine. 2015. 372(14):1291-1300.",
"title" : "Outcomes of anatomical versus functional testing for coronary artery disease",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1415516",
"pmid" : "25773919",
"published" : "2015-04-02",
"expansion" : "Prospective Multicenter Imaging Study for Evaluation of Chest Pain",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1415516",
"pageName" : "PROMISE"
},
{
"published" : "2018-02-13",
"expansion" : "Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients",
"pageName" : "PROPER",
"fulltexturl" : "https://jamanetwork.com/journals/jama/article-abstract/2672630",
"title" : "Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial",
"citation" : "Freund Y, et al. \"Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial\". Journal of the American Medical Association. 2018. 319(6):559-566.",
"pdfurl" : null,
"pmid" : "29450523",
"briefDesignDescription" : "Validation of PERC score in PE",
"abbreviation" : "PROPER",
"trainingLevel" : "Resident",
"timestamp" : "2023-04-21T16:19:29Z",
"pageid" : 3548,
"subspecialties" : "Emergency Medicine",
"statusUsableDate" : "2023-04-20",
"diseases" : "Pulmonary Embolism",
"briefResultsDescription" : "PERC score excludes PE in low-risk patients"
},
{
"pmid" : "25647203",
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/2107789/joi150002.pdf",
"title" : "Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial",
"citation" : "Holcomb JB, et al. \"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial\". JAMA. 2015. 313(5):471-482.",
"pageName" : "PROPPR",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/2107789",
"expansion" : "Pragmatic, Randomized Optimal Platelet and Plasma Ratios",
"published" : "2015-02-03",
"briefResultsDescription" : "1:1:1 ratio of FFP:PLT:RBC no better than 1:1:2",
"diseases" : "Hemorrhage;Trauma;Shock",
"statusUsableDate" : "2023-09-28",
"pageid" : 2504,
"timestamp" : "2023-09-28T19:19:28Z",
"subspecialties" : "Emergency Medicine;Critical Care;Hematology",
"abbreviation" : "PROPPR",
"briefDesignDescription" : "Transfusion ratios in hemorrhagic shock",
"trainingLevel" : "Resident"
},
{
"timestamp" : "2017-08-06T02:15:05Z",
"pageid" : 434,
"subspecialties" : "Critical Care;Infectious Disease",
"abbreviation" : "PRORATA",
"briefDesignDescription" : "Procalcitonin-guided antibiotics",
"trainingLevel" : "resident",
"diseases" : "Critical Illness",
"briefResultsDescription" : "Procalcitonin noninferior and led to fewer days on antibiotics",
"statusUsableDate" : "2012-03-01",
"pageName" : "PRORATA",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61879-1/fulltext",
"expansion" : "Procalcitonin to Reduce Antibiotic Treatments in Acutely ill patients",
"published" : "2010-02-06",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673609618791.pdf",
"pmid" : "20097417",
"title" : "Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units",
"citation" : "Bouadma L, et al. \"Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units\". The Lancet. 2010. 375(9713):463-74."
},
{
"title" : "Prone positioning in severe acute respiratory distress syndrome",
"citation" : "Guérin C, et al. \"Prone positioning in severe acute respiratory distress syndrome\". The New England Journal of Medicine. 2013. 368(23):2159-2168.",
"pmid" : "23688302",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214103",
"expansion" : "Proning Severe ARDS Patients",
"published" : "2013-06-06",
"pageName" : "PROSEVA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1214103",
"statusUsableDate" : "2013-06-01",
"briefResultsDescription" : "Intermittent prone positioning improves survival in severe ARDS",
"diseases" : "Acute Respiratory Distress Syndrome",
"abbreviation" : "PROSEVA",
"briefDesignDescription" : "Prone ventilation in ARDS",
"trainingLevel" : "fellow",
"pageid" : 1479,
"timestamp" : "2020-11-12T18:32:26Z",
"subspecialties" : "Critical Care"
},
{
"pdfurl" : "",
"pmid" : "19683639",
"title" : "Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial",
"citation" : "Holmes DR, et al. \"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial\". Lancet. 2009. 374(9689):534-42.",
"pageName" : "PROTECT AF",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61343-X/fulltext",
"expansion" : "WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation",
"published" : "2009-11-07",
"diseases" : "Atrial Fibrillation;Stroke",
"briefResultsDescription" : "LAA closure was noninferior to warfarin therapy",
"statusUsableDate" : "2018-01-18",
"timestamp" : "2025-05-15T20:05:21Z",
"pageid" : 2459,
"subspecialties" : "Cardiology",
"abbreviation" : "PROTECT AF",
"briefDesignDescription" : "LAA closure vs. warfarin in AF",
"trainingLevel" : "Intern"
},
{
"pageName" : "PROVE IT-TIMI 22",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040583",
"published" : "2004-04-08",
"expansion" : "Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22",
"pmid" : "15007110",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040583",
"title" : "Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes",
"citation" : "Cannon CP, et al. \"Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes\". The New England Journal of Medicine. 2004. 350(15):1495-1504.",
"pageid" : 1338,
"timestamp" : "2017-12-14T19:39:45Z",
"subspecialties" : "Cardiology",
"abbreviation" : "PROVE IT-TIMI 22",
"briefDesignDescription" : "Pravastatin vs. atorvastatin after ACS",
"trainingLevel" : "Intern",
"briefResultsDescription" : "High-dose atorvastatin is superior to moderate-dose pravastatin at reducing CV events after ACS",
"diseases" : "Acute Coronary Syndrome;Hyperlipidemia",
"statusUsableDate" : "2013-04-01"
},
{
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "Improved survival with APC but not seen in subsequent larger PROWESS-SHOCK trial",
"statusUsableDate" : "2012-09-01",
"timestamp" : "2017-12-03T22:38:41Z",
"pageid" : 983,
"subspecialties" : "Critical Care",
"abbreviation" : "PROWESS",
"briefDesignDescription" : "Activated protein C in severe sepsis",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200103083441001",
"pmid" : "11236773",
"title" : "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis",
"citation" : "Bernard GR, et al. \"Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis\". The New England Journal of Medicine. 2001. 344(10):699-709.",
"pageName" : "PROWESS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200103083441001",
"published" : "2001-03-08",
"expansion" : "Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis"
},
{
"statusUsableDate" : "2012-09-01",
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "No survival benefit at 28 or 90 days, in contrast to PROWESS",
"briefDesignDescription" : "Activated protein C in septic shock",
"abbreviation" : "PROWESS-SHOCK",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:38:43Z",
"pageid" : 977,
"subspecialties" : "Critical Care",
"title" : "Drotrecogin Alfa (Activated) in Adults with Septic Shock",
"citation" : "Ranieri VM, et al. \"Drotrecogin Alfa (Activated) in Adults with Septic Shock\". The New England Journal of Medicine. 2012. 366(22):2055-2064.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1202290",
"pmid" : "22616830",
"published" : "2012-05-31",
"expansion" : "Prospective Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis and Septic Shock",
"pageName" : "PROWESS-SHOCK",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1202290"
},
{
"title" : "Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)",
"citation" : "Umpierrez GE, et al. \"Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)\". Diabetes Care. 2007. 30(9):2181-2186.",
"pdfurl" : "http://care.diabetesjournals.org/content/30/9/2181.full-text.pdf",
"pmid" : "17513708",
"expansion" : "Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes",
"published" : "2007-09-30",
"pageName" : "RABBIT 2",
"fulltexturl" : "http://bit.ly/29xvPia",
"statusUsableDate" : "2018-06-14",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Basal-bolus more effective for glycemic control compared to sliding-scale insulin",
"briefDesignDescription" : "Basal-bolus insulin in inpatients with DM",
"abbreviation" : "RABBIT 2",
"trainingLevel" : "Intern",
"timestamp" : "2018-12-24T16:50:42Z",
"pageid" : 2720,
"subspecialties" : "Critical Care;Endocrinology"
},
{
"pageName" : "RACE 7 ACWAS",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1900353",
"published" : "2019-04-18",
"expansion" : "Rate Control versus Electrical Cardioversion Trial 7–Acute Cardioversion versus Wait and See",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1900353",
"pmid" : "30883054",
"title" : "Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation",
"citation" : "Pluymaekers NAHA, et al. \"Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation\". The New England Journal of Medicine. 2019. 380(16):1499-1508.",
"timestamp" : "2025-05-22T17:30:01Z",
"pageid" : 4062,
"subspecialties" : "Emergency Medicine;Cardiology",
"abbreviation" : "RACE 7 ACWAS",
"briefDesignDescription" : "Delayed vs. early cardioversion in AF",
"trainingLevel" : "Resident",
"diseases" : "Atrial Fibrillation",
"briefResultsDescription" : "Delayed is noninferior to early cardioversion in obtaining sinus rhythm",
"statusUsableDate" : "2025-05-25"
},
{
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Lenient rate control is as effective as strict rate control",
"diseases" : "Atrial Fibrillation",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Lenient vs. strict rate control in AF",
"abbreviation" : "RACE II",
"subspecialties" : "Cardiology",
"pageid" : 181,
"timestamp" : "2025-05-15T20:17:08Z",
"citation" : "Van Gelder IC, et al. \"Lenient versus Strict Rate Control in Patients with Atrial Fibrillation\". The New England Journal of Medicine. 2010. 362(15):1363-73.",
"title" : "Lenient versus Strict Rate Control in Patients with Atrial Fibrillation",
"pmid" : "20231232",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001337",
"published" : "2010-04-15",
"expansion" : "Rate Control Efficacy in Permanent Atrial Fibrillation: a Comparison between Lenient versus Strict Rate Control II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001337",
"pageName" : "RACE II"
},
{
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/196680/joc22401.pdf",
"pmid" : "12783911",
"citation" : "Jarvik JG, et al. \"Rapid magnetic resonance imaging vs. radiographs for patients with low back pain: a randomized controlled trial.\". The Journal of the American Medical Association. 2003. 289(21):2810-8.",
"title" : "Rapid magnetic resonance imaging vs. radiographs for patients with low back pain: a randomized controlled trial.",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/196680",
"pageName" : "Radiograph vs. MRI for low back pain",
"published" : "2003-06-04",
"expansion" : "",
"diseases" : "Low Back Pain",
"briefResultsDescription" : "No differences in pain or disability related to back pain, possibly more surgeries in MRI group",
"statusUsableDate" : "2018-10-31",
"subspecialties" : "Physical Medicine and Rehabilitation",
"timestamp" : "2025-06-19T18:35:37Z",
"pageid" : 2665,
"trainingLevel" : "Intern",
"abbreviation" : "Radiograph vs. MRI for low back pain",
"briefDesignDescription" : "Radiograph vs. MRI for low back pain"
},
{
"pageName" : "RAFT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009540",
"published" : "2010-12-16",
"expansion" : "Resynchronization–Defibrillation for Ambulatory Heart Failure",
"pmid" : "21073365",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009540",
"title" : "Cardiac-resynchronization therapy for mild-to-moderate heart failure",
"citation" : "Tang AS, et al. \"Cardiac-resynchronization therapy for mild-to-moderate heart failure\". The New England Journal of Medicine. 2010. 363(25):2385-2395.",
"pageid" : 2731,
"timestamp" : "2017-12-03T22:38:47Z",
"subspecialties" : "Cardiology",
"briefDesignDescription" : "CRT+ICD for mild-moderate HFrEF",
"abbreviation" : "RAFT",
"trainingLevel" : "Resident",
"briefResultsDescription" : "CRT+ICD reduces mortality but increased the rate of adverse events",
"diseases" : "Heart Failure",
"statusUsableDate" : "2016-09-01"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199909023411001",
"pageName" : "RALES",
"published" : "1999-09-02",
"expansion" : "Randomized Aldactone Evaluation Study",
"pmid" : "10471456",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199909023411001",
"citation" : "Pitt B, et al. \"The effect of spironolactone on morbidity and mortality in patients with severe heart failure\". New England Journal of Medicine. 1999. 341(10):709-717.",
"title" : "The effect of spironolactone on morbidity and mortality in patients with severe heart failure",
"subspecialties" : "Cardiology",
"pageid" : 11,
"timestamp" : "2015-08-24T04:40:44Z",
"trainingLevel" : "Intern",
"abbreviation" : "RALES",
"briefDesignDescription" : "Spironolactone in HFrEF",
"briefResultsDescription" : "Spironolactone reduces all-cause mortality by 30% in severe HFrEF",
"diseases" : "Heart Failure",
"statusUsableDate" : "2012-03-01"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1107494",
"pageName" : "RAMPART",
"published" : "2012-02-22",
"expansion" : "Rapid Anticonvulsant Medication Prior to Arrival Trial",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1107494",
"pmid" : "22335736",
"citation" : "Silbergleit R, et al. \"Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus\". The New England Journal of Medicine. 2012. 366(7):591-600.",
"title" : "Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus",
"subspecialties" : "Neurology",
"timestamp" : "2021-08-12T22:54:12Z",
"pageid" : 2505,
"trainingLevel" : "Intern",
"briefDesignDescription" : "Midazolam vs. lorazepam for status epilepticus",
"abbreviation" : "RAMPART",
"diseases" : "Epilepsy;Seizure",
"briefResultsDescription" : "IM midazolam is as safe and efficacious as IV lorazepam",
"statusUsableDate" : "2019-08-31"
},
{
"pageid" : 5600,
"timestamp" : "2025-05-22T17:14:03Z",
"subspecialties" : "Oncology",
"briefDesignDescription" : "Chemo-RT vs. chemo in rectal cancer",
"abbreviation" : "RAPIDO",
"trainingLevel" : "Fellow",
"briefResultsDescription" : "Fewer treatment failures with chemo-RT",
"diseases" : "Colorectal Cancer",
"statusUsableDate" : "2025-05-22",
"pageName" : "RAPIDO",
"fulltexturl" : "https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30555-6/fulltext",
"expansion" : "Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation Trial",
"published" : "2021-01-01",
"pmid" : "33301740",
"pdfurl" : "https://www.thelancet.com/action/showPdf?pii",
"title" : "Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial",
"citation" : "Bahadoer RR, et al. \"Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial\". The Lancet Oncology. 2021. 22(1):29-42."
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909905",
"pmid" : "20647199",
"title" : "Rituximab versus cyclophosphamide for ANCA-associated vasculitis",
"citation" : "Stone JH, et al. \"Rituximab versus cyclophosphamide for ANCA-associated vasculitis\". The New England Journal of Medicine. 2010. 363(3):221-232.",
"pageName" : "RAVE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909905",
"published" : "2010-07-15",
"expansion" : "Rituximab in ANCA-Associated Vasculitis",
"diseases" : "Vasculitis",
"briefResultsDescription" : "Rituximab noninferior to cyclophosphamide in ANCA-associated vasculitis",
"statusUsableDate" : "2013-02-01",
"timestamp" : "2017-12-03T22:38:49Z",
"pageid" : 1214,
"subspecialties" : "Rheumatology",
"briefDesignDescription" : "Rituximab vs. cyclophosphamide in ANCA-associated vasculitis",
"abbreviation" : "RAVE",
"trainingLevel" : "Fellow"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300615",
"pmid" : "23991661",
"title" : "Dabigatran versus warfarin in patients with mechanical heart valves",
"citation" : "Eikelboom JW, et al. \"Dabigatran versus warfarin in patients with mechanical heart valves\". The New England Journal of Medicine. 2013. 369(13):1206-1214.",
"pageName" : "RE-ALIGN",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300615",
"expansion" : "Randomized, Phase II Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients after Heart Valve Replacement",
"published" : "2013-09-26",
"diseases" : "Valvular Disease",
"briefResultsDescription" : "Dabigatran has more thromboembolism and bleeding than warfarin",
"statusUsableDate" : "2013-10-01",
"timestamp" : "2017-12-03T22:38:51Z",
"pageid" : 1707,
"subspecialties" : "Cardiology;Hematology",
"briefDesignDescription" : "Dabigatran in mechanical heart valves",
"abbreviation" : "RE-ALIGN",
"trainingLevel" : "Resident"
},
{
"trainingLevel" : "fellow",
"briefDesignDescription" : "Dabigatran vs. warfarin in VTE",
"abbreviation" : "RE-COVER",
"subspecialties" : "Hematology;Pulmonology",
"timestamp" : "2017-12-03T22:38:52Z",
"pageid" : 973,
"statusUsableDate" : "2012-08-01",
"diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
"briefResultsDescription" : "Dabigatran non-inferior to warfarin for VTE recurrence, but dabigatran yielded less bleeding",
"expansion" : "Efficacy and Safety of Dabigatran Compared to Warfarin for 6 Month Treatment of Acute Symptomatic Venous Thromboembolism",
"published" : "2009-12-10",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906598",
"pageName" : "RE-COVER",
"citation" : "Schulman S, et al. \"Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism\". New England Journal of Medicine. 2009. 361(24):2342-52.",
"title" : "Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906598",
"pmid" : "19966341"
},
{
"subspecialties" : "Cardiology",
"pageid" : 3527,
"timestamp" : "2018-01-30T17:09:14Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Triple therapy vs. ASA+dabigatran in PCI if AF",
"abbreviation" : "RE-DUAL PCI",
"briefResultsDescription" : "Aspirin and dabigatran nonferior to triple therapy in patients with AF undergoing PCI",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2018-01-29",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1708454",
"pageName" : "RE-DUAL",
"expansion" : "Randomized evaluation of dual antithrombotic therapy with dabigatran versus triple therapy with warfarin in patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention",
"published" : "2017-10-19",
"pmid" : "28844193",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1708454",
"citation" : "Cannon CP, et al. \"Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation\". The New England Journal of Medicine. 2017. 377(16):1513-1524.",
"title" : "Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation"
},
{
"pmid" : "19717844",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0905561",
"citation" : "Connolly SJ, et al. \"Dabigatran versus warfarin in patients with atrial fibrillation\". The New England Journal of Medicine. 2009. 361(12):1139-51.",
"title" : "Dabigatran versus warfarin in patients with atrial fibrillation",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0905561",
"pageName" : "RE-LY",
"published" : "2009-09-17",
"expansion" : "Randomized Evaluation of Long-Term Anticoagulation Therapy",
"briefResultsDescription" : "High-dose dabigatran reduces stroke risk without increasing major bleeding in atrial fibrillation",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Cardiology;Neurology",
"pageid" : 178,
"timestamp" : "2015-04-18T21:22:31Z",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Dabigatran vs. warfarin in AF",
"abbreviation" : "RE-LY"
},
{
"trainingLevel" : "Intern",
"abbreviation" : "RE-VERSE AD",
"briefDesignDescription" : "Idarucizumab for dabigatran reversal",
"subspecialties" : "Hematology",
"pageid" : 2421,
"timestamp" : "2017-12-03T22:38:54Z",
"statusUsableDate" : "2016-01-01",
"briefResultsDescription" : "Idarucizumab reversed the dabigatran effect in minutes",
"diseases" : "Hemorrhage",
"expansion" : "",
"published" : "2015-08-06",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1502000",
"pageName" : "RE-VERSE AD",
"citation" : "Pollack CV, et al. \"Idarucizumab for Dabigatran Reversal\". The New England Journal of Medicine. 2015. 373(6):511-520.",
"title" : "Idarucizumab for Dabigatran Reversal",
"pmid" : "26095746",
"pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1502000"
},
{
"title" : "Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia",
"citation" : "Ducrocq G, et al. \"Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia\". Journal of the American Medical Association. 2021. 325(6):552-560.",
"pdfurl" : null,
"pmid" : "33560322",
"expansion" : "Restrictive and Liberal Transfusion Strategies in Patients With Acute Myocardial Infarction trial",
"published" : "2021-02-09",
"pageName" : "REALITY",
"fulltexturl" : "https://doi.org/10.1001/jama.2021.0135",
"statusUsableDate" : "2021-07-31",
"diseases" : "Acute Coronary Syndrome",
"briefResultsDescription" : "Restrictive threshold non-inferior to liberal transfusion threshold",
"briefDesignDescription" : "Transfusion thresholds in MI",
"abbreviation" : "REALITY",
"trainingLevel" : "Resident",
"timestamp" : "2021-08-05T18:21:13Z",
"pageid" : 4431,
"subspecialties" : "Cardiology"
},
{
"statusUsableDate" : "2020-08-20",
"diseases" : "Covid-19",
"briefResultsDescription" : "Dexamethasone improved survival in a subset of patients with Covid-19",
"briefDesignDescription" : "Dexamethasone vs. usual care in Covid-19",
"abbreviation" : "RECOVERY",
"trainingLevel" : "Student",
"timestamp" : "2020-10-29T17:10:25Z",
"pageid" : 4273,
"subspecialties" : "Infectious Disease",
"title" : "Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report",
"citation" : "Horby P, et al. \"Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report\". The New England Journal of Medicine. 2020. e-pub 2020-07-17:1-11.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021436",
"pmid" : "32678530",
"published" : "2020-07-17",
"expansion" : "Randomized Evaluation of Covid-19 Therapy",
"pageName" : "RECOVERY (Covid-19)",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2021436"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214865",
"pmid" : "23473338",
"title" : "Treatment of anemia with darbepoetin alfa in systolic heart failure",
"citation" : "Swedberg K, et al. \"Treatment of anemia with darbepoetin alfa in systolic heart failure\". The New England Journal of Medicine. 2013. 368(13):1210-9.",
"pageName" : "RED-HF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1214865",
"published" : "2013-03-28",
"expansion" : "Reduction of Events by Darbepoetin Alfa in Heart Failure",
"diseases" : "Heart Failure;Anemia",
"briefResultsDescription" : "Darbepoetin does not improve clinical outcomes in HF with anemia",
"statusUsableDate" : "2014-06-01",
"timestamp" : "2017-12-03T22:38:55Z",
"pageid" : 1842,
"subspecialties" : "Cardiology;Hematology",
"briefDesignDescription" : "Darbepoetin in HFrEF",
"abbreviation" : "RED-HF",
"trainingLevel" : "Fellow"
},
{
"briefResultsDescription" : "5d steroids noninferior to 14d in acute COPD",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"statusUsableDate" : "2013-09-01",
"pageid" : 1615,
"timestamp" : "2017-12-03T22:38:56Z",
"subspecialties" : "Pulmonology",
"briefDesignDescription" : "5d vs. 14d steroids in acute COPD",
"abbreviation" : "REDUCE",
"trainingLevel" : "Intern",
"pmid" : "23695200",
"pdfurl" : null,
"title" : "Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial",
"citation" : "Leuppi JD, et al. \"Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial\". JAMA. 2013. 309(21):2223-2231.",
"pageName" : "REDUCE",
"fulltexturl" : "http://bit.ly/1BQhpuy",
"published" : "2013-06-05",
"expansion" : "Reduction in the Use of Corticosteroids in Exacerbated COPD"
},
{
"briefDesignDescription" : "Beta-blockers if post-AMI LVEF ≥50%",
"abbreviation" : "REDUCE-AMI",
"trainingLevel" : "students",
"timestamp" : "2024-05-16T18:52:20Z",
"pageid" : 5504,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2024-05-16",
"diseases" : "Myocardial Infarction",
"briefResultsDescription" : "Beta-Blockers no better than no beta-blockers in MI with normal LVEF",
"published" : "2024-04-18",
"expansion" : "",
"pageName" : "REDUCE-AMI",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2401479",
"title" : "Beta-blockers after myocardial infarction and preserved ejection fraction",
"citation" : "Yndigegn T, et al. \"Beta-blockers after myocardial infarction and preserved ejection fraction\". The New England Journal of Medicine. 2024. 390(15):1372-1381.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2401479",
"pmid" : "38587241"
},
{
"briefResultsDescription" : "Icosapent ethyl superior to placebo in CAD with hypertriglyceridemia",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2018-12-27",
"pageid" : 3748,
"timestamp" : "2019-10-17T17:47:07Z",
"subspecialties" : "Cardiology",
"abbreviation" : "REDUCE-IT",
"briefDesignDescription" : "Icosapent ethyl in CAD",
"trainingLevel" : "Resident",
"pmid" : "30415628",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812792",
"title" : "Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia",
"citation" : "Bhatt DL, et al. \"Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia\". The New England Journal of Medicine. 2018. epub 2018-11-10:1-12.",
"pageName" : "REDUCE-IT",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812792",
"published" : "2018-11-10",
"expansion" : "Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial"
},
{
"statusUsableDate" : "2017-10-01",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Sildenafil not superior to placebo in HFpEF",
"briefDesignDescription" : "Sildenafil vs. placebo in HFpEF",
"abbreviation" : "RELAX",
"trainingLevel" : "Resident",
"timestamp" : "2017-12-03T22:38:58Z",
"pageid" : 2973,
"subspecialties" : "Cardiology",
"title" : "Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction",
"citation" : "Redfield MM, et al. \"Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction\". JAMA. 2013. 309(12):1268-1277.",
"pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/1663257/joc130025_1268_1277.pdf",
"pmid" : "23478662",
"expansion" : "Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction",
"published" : "2013-03-11",
"pageName" : "RELAX",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/1663257"
},
{
"pmid" : "11794191",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa012175",
"citation" : "Rose EA, et al. \"Long-term use of a left ventricular assist device for end-stage heart failure\". The New England Journal of Medicine. 2001. 345(20):1435-43.",
"title" : "Long-term use of a left ventricular assist device for end-stage heart failure",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa012175",
"pageName" : "REMATCH",
"published" : "2001-11-15",
"expansion" : "Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure",
"briefResultsDescription" : "LVAD reduced all-cause mortality in end-stage heart failure",
"diseases" : "Heart Failure",
"statusUsableDate" : "2019-04-11",
"subspecialties" : "Cardiology",
"pageid" : 2822,
"timestamp" : "2019-04-11T17:01:50Z",
"trainingLevel" : "Fellow",
"abbreviation" : "REMATCH",
"briefDesignDescription" : "Destination LVAD in end-stage heart failure"
},
{
"statusUsableDate" : "2013-01-01",
"diseases" : "Diabetes Mellitus;Chronic Kidney Disease",
"briefResultsDescription" : "ARBs reduce progression to",
"briefDesignDescription" : "ARBs in diabetic nephropathy",
"abbreviation" : "RENAAL",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:38:59Z",
"pageid" : 1030,
"subspecialties" : "Endocrinology;Nephrology",
"title" : "Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy",
"citation" : "Brenner BM, et al. \"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy\". The New England Journal of Medicine. 2001. 345(12):861-869.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011161",
"pmid" : "11565518",
"expansion" : "Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan",
"published" : "2001-09-20",
"pageName" : "RENAAL",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011161"
},
{
"abbreviation" : "RESCUEicp",
"briefDesignDescription" : "Craniectomy vs. medical care for intracranial hypertension",
"trainingLevel" : "Resident",
"timestamp" : "2018-07-22T21:45:32Z",
"pageid" : 3596,
"subspecialties" : "Surgery;Neurology",
"statusUsableDate" : "2018-07-19",
"diseases" : "Intracranial Hypertension;Traumatic Brain Injury",
"briefResultsDescription" : "Craniectomy reduced mortality by 22% compared to usual care",
"published" : "2016-09-22",
"expansion" : "Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure",
"pageName" : "RESCUEicp",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1605215",
"title" : "Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension",
"citation" : "Hutchinson PJ, et al. \"Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension\". The New England Journal of Medicine. 2016. 375(12):1119-30.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1605215",
"pmid" : "27602507"
},
{
"pageid" : 1334,
"timestamp" : "2017-12-03T22:39:00Z",
"subspecialties" : "Neurology;Cardiology",
"abbreviation" : "RESPECT",
"briefDesignDescription" : "PFO closure in cryptogenic stroke",
"trainingLevel" : "Intern",
"briefResultsDescription" : "PFO closure does not reduce recurrent CVA after cryptogenic CVA",
"diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
"statusUsableDate" : "2013-05-01",
"pageName" : "RESPECT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1301440",
"expansion" : "Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment",
"published" : "2013-03-21",
"pmid" : "23514286",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1301440",
"title" : "Closure of patent foramen ovale versus medical therapy after cryptogenic stroke",
"citation" : "Carroll JD, et al. \"Closure of patent foramen ovale versus medical therapy after cryptogenic stroke\". The New England Journal of Medicine. 2013. 368(12):1092-1100."
},
{
"published" : "2013-09-01",
"expansion" : "",
"pageName" : "Rifaximin and Lactulose for HE",
"fulltexturl" : "http://www.nature.com/ajg/journal/v108/n9/full/ajg2013219a.html",
"title" : "A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy",
"citation" : "Sharma BC, et al. \"A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy\". The American Journal of Gastroenterology. 2013. 108(9):1458-1463.",
"pdfurl" : "http://www.nature.com/ajg/journal/v108/n9/pdf/ajg2013219a.pdf",
"pmid" : "23877348",
"abbreviation" : "",
"briefDesignDescription" : "Rifaximin/lactulose vs. lactulose for acute HE",
"trainingLevel" : "Intern",
"timestamp" : "2017-12-03T22:39:03Z",
"pageid" : 1784,
"subspecialties" : "Gastroenterology",
"statusUsableDate" : "2014-03-01",
"diseases" : "Hepatic Encephalopathy",
"briefResultsDescription" : "Rifaximin/lactulose improved rates of HE reversal and survival, reduced hospital LOS"
},
{
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa0909169",
"pmid" : "20647198",
"citation" : "Jones RB, et al. \"Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis\". The New England Journal of Medicine. 2010. 363(3):211-232.",
"title" : "Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa0909169",
"pageName" : "RITUXVAS",
"published" : "2010-07-15",
"expansion" : "",
"diseases" : "Vasculitis;ANCA-Associated Vasculitis;Renal Vasculitis",
"briefResultsDescription" : "Rituximab not superior to cyclophosphamide",
"statusUsableDate" : "2022-03-10",
"subspecialties" : "Rheumatology;Nephrology",
"timestamp" : "2022-03-10T21:09:46Z",
"pageid" : 4459,
"trainingLevel" : "fellow",
"briefDesignDescription" : "Rituximab in ANCA-Renal Vasculitis",
"abbreviation" : "RITUXVAS"
},
{
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "Early goal-directed therapy decreased mortality and morbiditiy in sepsis",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2022-04-19T13:00:26Z",
"pageid" : 60,
"subspecialties" : "Critical Care;Emergency Medicine",
"abbreviation" : "",
"briefDesignDescription" : "Early goal-directed therapy in sepsis",
"trainingLevel" : "Student",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010307",
"pmid" : "11794169",
"title" : "Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock",
"citation" : "Rivers E, et al. \"Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock\". The New England Journal of Medicine. 2001. 345(19):1368-1377.",
"pageName" : "Rivers Trial",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010307",
"published" : "2001-11-08",
"expansion" : ""
},
{
"pageid" : 1358,
"timestamp" : "2017-12-03T22:39:02Z",
"subspecialties" : "Cardiology;Neurology",
"briefDesignDescription" : "Rivaroxaban vs. warfarin in AF",
"abbreviation" : "ROCKET AF",
"trainingLevel" : "Student",
"briefResultsDescription" : "Rivaroxaban is noninferior to warfarin for stroke/embolization prevention in nonvalvular AF",
"diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
"statusUsableDate" : "2013-04-01",
"pageName" : "ROCKET AF",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009638",
"expansion" : "Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation",
"published" : "2011-09-08",
"pmid" : "21830957",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009638",
"title" : "Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation",
"citation" : "Patel MR, et al. \"Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation\". The New England Journal of Medicine. 2011. 365(10):883-891."
},
{
"title" : "Early neuromuscular blockade in the acute respiratory distress syndrome",
"citation" : "National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. \"Early neuromuscular blockade in the acute respiratory distress syndrome\". The New England Journal of Medicine. 2019. 380(21):1997-2008.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1901686",
"pmid" : "31112383",
"expansion" : "Reevaluation of Systemic Early Neuromuscular Blockade",
"published" : "2019-05-23",
"pageName" : "ROSE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1901686",
"statusUsableDate" : "2019-06-14",
"diseases" : "Acute Respiratory Distress Syndrome",
"briefResultsDescription" : "Cisatracurium blockade doesn't improve outcomes in ARDS",
"abbreviation" : "ROSE",
"briefDesignDescription" : "Cisatracurium NM blockade in ARDS",
"trainingLevel" : "Resident",
"timestamp" : "2020-07-12T00:30:51Z",
"pageid" : 4070,
"subspecialties" : "Critical Care"
},
{
"expansion" : "",
"published" : "2018-10-01",
"fulltexturl" : "https://doi.org/10.1001/jamainternmed.2018.4204",
"pageName" : "S-HYDRACYST",
"citation" : "Hooton TM, et al. \"Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections\". JAMA Internal Medicine. 2018. 178(11):1509-1515.",
"title" : "Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections",
"pmid" : "30285042",
"pdfurl" : "",
"trainingLevel" : "Student",
"abbreviation" : "",
"briefDesignDescription" : "Water intake to prevent UTI",
"subspecialties" : "Infectious Disease;Urology;Gynecology",
"pageid" : 4072,
"timestamp" : "2022-12-01T20:14:11Z",
"statusUsableDate" : "2019-09-15",
"briefResultsDescription" : "Drinking more water reduces recurrent UTIs in premenopausal women",
"diseases" : "Urinary Tract Infections"
},
{
"title" : "Sertraline treatment of major depression in patients with acute MI or unstable angina",
"citation" : "Glassman AH, et al. \"Sertraline treatment of major depression in patients with acute MI or unstable angina\". Journal of the American Medical Association. 2002. 288(6):701-709.",
"pdfurl" : "http://jama.ama-assn.org/content/288/6/701.full.pdf",
"pmid" : "12169073",
"expansion" : "Sertraline Antidepressant Heart Attack Randomized Trial",
"published" : "2002-08-14",
"pageName" : "SADHART",
"fulltexturl" : "http://jama.ama-assn.org/content/288/6/701.full",
"statusUsableDate" : "2012-05-01",
"diseases" : "Depression;Acute Coronary Syndrome",
"briefResultsDescription" : "Sertraline improves symptoms without adverse CV effects",
"abbreviation" : "SADHAT",
"briefDesignDescription" : "Sertraline for depression post-ACS",
"trainingLevel" : "Resident",
"timestamp" : "2018-09-04T17:00:07Z",
"pageid" : 423,
"subspecialties" : "Psychiatry;Cardiology"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040232",
"pmid" : "15163774",
"title" : "A comparison of albumin and saline for fluid resuscitation in the intensive care unit",
"citation" : "Finfer S, et al. \"A comparison of albumin and saline for fluid resuscitation in the intensive care unit\". The New England Journal of Medicine. 2004. 350(22):2247-2256.",
"pageName" : "SAFE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040232",
"expansion" : "Saline versus Albumin Fluid Evaluation",
"published" : "2004-05-27",
"diseases" : "Critical Illness",
"briefResultsDescription" : "No mortality difference (except worse mortality with albumin for TBI)",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2017-01-19T20:07:27Z",
"pageid" : 285,
"subspecialties" : "Critical Care",
"briefDesignDescription" : "Albumin vs. saline in ICU",
"abbreviation" : "SAFE",
"trainingLevel" : "Intern"
},
{
"pageName" : "SALT-ED",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711586",
"published" : "2018-03-01",
"expansion" : "Saline Against Lactated Ringer's or Plasma-Lyte in the Emergency Department",
"pmid" : "29485926",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711586",
"title" : "Balanced crystalloids versus saline in noncritically ill adults",
"citation" : "Self WH, et al. \"Balanced crystalloids versus saline in noncritically ill adults\". The New England Journal of Medicine. 2018. 378(10):819-828.",
"pageid" : 3556,
"timestamp" : "2018-04-05T18:17:47Z",
"subspecialties" : "Critical Care;Nephrology",
"abbreviation" : "SALT-ED",
"briefDesignDescription" : "Balanced crystalloids vs. NS in non-critical ED patients",
"trainingLevel" : "Student",
"briefResultsDescription" : "Balanced crystalloids result in fewer renal abnormalities",
"diseases" : "Hypovolemia;Acute Kidney Injury",
"statusUsableDate" : "2018-04-05"
},
{
"citation" : "Chimowitz MI, et al. \"Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis\". The New England Journal of Medicine. 2015. 365(11):993-1003.",
"title" : "Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa1105335",
"pmid" : "24168957",
"expansion" : "",
"published" : "2011-09-15",
"fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa1105335",
"pageName" : "SAMMPRIS",
"statusUsableDate" : "2016-03-01",
"diseases" : "Stroke",
"briefResultsDescription" : "Medical therapy superior to stenting in IC stenosis",
"trainingLevel" : "Intern",
"abbreviation" : "SAMMPRIS",
"briefDesignDescription" : "Stenting in intracranial stenosis",
"subspecialties" : "Neurology;Interventional Radiology",
"timestamp" : "2019-06-27T16:40:34Z",
"pageid" : 2420
},
{
"expansion" : "Survival and Ventricular Enlargement Trial",
"published" : "1992-09-03",
"pageName" : "SAVE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199209033271001",
"title" : "Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial",
"citation" : "Pfeffer MA, et al. \"Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial\". The New England Journal of Medicine. 1992. 327(10):669-677.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199209033271001",
"pmid" : "1386652",
"briefDesignDescription" : "Captopril in MI with LV dysfunction",
"abbreviation" : "SAVE",
"trainingLevel" : "Resident",
"timestamp" : "2015-08-24T04:52:18Z",
"pageid" : 150,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2012-03-01",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Heart Failure",
"briefResultsDescription" : "Captopril improves survival"
},
{
"abbreviation" : "SCD-HeFT",
"briefDesignDescription" : "Amiodarone or ICD in severe HFrEF",
"trainingLevel" : "Intern",
"timestamp" : "2019-05-16T20:18:55Z",
"pageid" : 40,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2012-03-01",
"diseases" : "Heart Failure",
"briefResultsDescription" : "ICD reduces mortality by 23% in class II-III HFrEF",
"expansion" : "Sudden Cardiac Death in Heart Failure Trial",
"published" : "2005-01-20",
"pageName" : "SCD-HeFT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa043399",
"title" : "Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure",
"citation" : "Bardy GH, et al. \"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure\". The New England Journal of Medicine. 2005. 252(3):225-37.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043399",
"pmid" : "15659722"
},
{
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "CTCA lowers CVD events",
"statusUsableDate" : "2025-08-31",
"subspecialties" : "Cardiology",
"timestamp" : "2025-09-11T19:23:41Z",
"pageid" : 3711,
"trainingLevel" : "resident",
"briefDesignDescription" : "CT coronary angiogram in stable angina",
"abbreviation" : "SCOT-HEART",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1805971",
"pmid" : "30145934",
"citation" : "Newby DE, et al. \"Coronary CT Angiography and 5-Year Risk of Myocardial Infarction\". The New England Journal of Medicine. 2018. 379(10):924-933.",
"title" : "Coronary CT Angiography and 5-Year Risk of Myocardial Infarction",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1805971",
"pageName" : "SCOT-HEART",
"published" : "2018-09-06",
"expansion" : "Scottish COmputed Tomography of the HEART"
},
{
"pdfurl" : "http://jama.ama-assn.org/content/301/5/489.full.pdf",
"pmid" : "19188334",
"title" : "Dexmedetomidine vs. Midazolam for Sedation of Critically Ill Patients",
"citation" : "Riker RR, et al. \"Dexmedetomidine vs. Midazolam for Sedation of Critically Ill Patients\". Journal of American Medical Association. 2009. 301(5):489-499.",
"pageName" : "SEDCOM",
"fulltexturl" : "http://jama.ama-assn.org/content/301/5/489.long",
"published" : "2009-02-04",
"expansion" : "Safety and Efficacy of Dexmedetomidine Compared with Midazolam",
"diseases" : "Critical Illness",
"briefResultsDescription" : "↓ delirium, ↓ ventilator days with dexmedetomidine",
"statusUsableDate" : "2012-04-01",
"timestamp" : "2021-02-14T17:21:07Z",
"pageid" : 353,
"subspecialties" : "Critical Care",
"briefDesignDescription" : "Dexmedetomidine vs. midazolam for sedation",
"abbreviation" : "SEDCOM",
"trainingLevel" : "Resident"
},
{
"statusUsableDate" : "2023-11-15",
"diseases" : "Cardiovascular Disease",
"briefResultsDescription" : "GLP-1 lowers CVD risk in non-diabetics with high BMI and prior CVD",
"trainingLevel" : "student",
"briefDesignDescription" : "GLP-1 if prior CVD, BMI ≥27, no DM",
"abbreviation" : "SELECT",
"subspecialties" : "Cardiology",
"timestamp" : "2025-06-19T18:41:58Z",
"pageid" : 5457,
"citation" : "Lincoff AM, et al. \"Semaglutide and cardiovascular outcomes in obesity without diabetes\". The New England Journal of Medicine. 2023. Epub 2023-11-11:1-12.",
"title" : "Semaglutide and cardiovascular outcomes in obesity without diabetes",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2307563",
"pmid" : "37952131",
"expansion" : "Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity",
"published" : "2023-11-11",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2307563",
"pageName" : "SELECT"
},
{
"subspecialties" : "Hematology;Oncology",
"timestamp" : "2024-08-29T19:21:15Z",
"pageid" : 3717,
"trainingLevel" : "Resident",
"abbreviation" : "SELECT-D",
"briefDesignDescription" : "Rivaroxaban vs. LMWH in cancer VTE",
"diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
"briefResultsDescription" : "Rivaroxaban noninferior to dalteparin in cancer VTE",
"statusUsableDate" : "2018-12-20",
"fulltexturl" : "http://ascopubs.org/doi/full/10.1200/JCO.2018.78.8034",
"pageName" : "SELECT-D",
"expansion" : "Anticoagulation Therapy in Selected Cancer Patients at Risk of Recurrence of Venous Thromboembolism",
"published" : "2018-07-10",
"pdfurl" : "http://ascopubs.org/doi/pdfdirect/10.1200/JCO.2018.78.8034",
"pmid" : "29746227",
"citation" : "Young AM, et al. \"Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D)\". Journal of Clinical Oncology. 2018. 36(20):2017-23.",
"title" : "Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D)"
},
{
"briefDesignDescription" : "MAP 65-70 vs. 80-85 mmHg in sepsis",
"abbreviation" : "SEPSISPAM",
"trainingLevel" : "Resident",
"pageid" : 1779,
"timestamp" : "2019-04-24T01:13:29Z",
"subspecialties" : "Critical Care",
"statusUsableDate" : "2014-04-01",
"briefResultsDescription" : "No difference for higher MAP in sepsis except renal protection in vascular disease",
"diseases" : "Sepsis;Shock",
"expansion" : "Sepsis and Mean Arterial Pressure",
"published" : "2014-04-23",
"pageName" : "SEPSISPAM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1312173",
"title" : "High versus low blood-pressure target in patients with septic shock",
"citation" : "Asfar P, et al. \"High versus low blood-pressure target in patients with septic shock\". The New England Journal of Medicine. 2014. 370(17):1583-1593.",
"pmid" : "24635770",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1312173"
},
{
"published" : "2010-09-11",
"expansion" : "Systolic Heart failure treatment with the If inhibitor ivabradine Trial",
"pageName" : "SHIFT",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0140673610611981",
"title" : "Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study",
"citation" : "Swedberg K et al. \"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study\". Lancet. 2010. 376(10):875-885.",
"pmid" : "20801500",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(10)61198-1.pdf",
"abbreviation" : "SHIFT",
"briefDesignDescription" : "Ivabradine in HFrEF",
"trainingLevel" : "Resident",
"pageid" : 2735,
"timestamp" : "2017-12-03T22:39:10Z",
"subspecialties" : "Cardiology",
"statusUsableDate" : "2016-05-01",
"briefResultsDescription" : "Ivabradine improves mortality and heart failure hospitalization in HFrEF",
"diseases" : "Heart Failure"
},
{
"abbreviation" : "SHOCK",
"briefDesignDescription" : "Early PCI/CABG in MI + shock",
"trainingLevel" : "Resident",
"pageid" : 388,
"timestamp" : "2017-12-03T22:39:12Z",
"subspecialties" : "Cardiology;Critical Care",
"statusUsableDate" : "2012-04-01",
"briefResultsDescription" : "Early PCI/CABG improves survival in acute MI and cardiogenic shock",
"diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
"published" : "1999-08-26",
"expansion" : "SHould we emergently revascularize Occluded Coronaries for Cardiogenic shocK",
"pageName" : "SHOCK",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199908263410901",
"title" : "Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock",
"citation" : "Hochman JS, et al. \"Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock\". The New England Journal of Medicine. 1999. 341(9):625-634.",
"pmid" : "10460813",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199908263410901"
},
{
"pageName" : "SMART",
"fulltexturl" : "http://bit.ly/1VSBfoL",
"published" : "2006-01-01",
"expansion" : "Salmeterol Multicenter Asthma Research Trial",
"pdfurl" : "http://journal.publications.chestnet.org/data/Journals/CHEST/22038/15.pdf",
"pmid" : "16424409",
"title" : "The salmeterol multicenter asthma research trial",
"citation" : "Nelson HS, et al. \"The salmeterol multicenter asthma research trial\". Chest. 2006. 129(1):15-26.",
"timestamp" : "2017-12-03T22:39:13Z",
"pageid" : 512,
"subspecialties" : "Pulmonology",
"briefDesignDescription" : "Salmeterol in asthma",
"abbreviation" : "SMART",
"trainingLevel" : "intern",
"diseases" : "Asthma",
"briefResultsDescription" : "Salmeterol increases death in subgroups",
"statusUsableDate" : "2012-08-01"
},
{
"diseases" : "Critical Illness",
"briefResultsDescription" : "Balanced crystalloids slightly reduced composite rate of death, RRT, or CKD",
"statusUsableDate" : "2018-04-05",
"subspecialties" : "Critical Care;Nephrology",
"timestamp" : "2018-04-05T17:39:53Z",
"pageid" : 3555,
"trainingLevel" : "student",
"abbreviation" : "SMART",
"briefDesignDescription" : "NS vs. balanced crystalloids in ICU",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711584",
"pmid" : "29485925",
"citation" : "Semler MW, et al. \"Balanced Crystalloids versus Saline in Critically Ill Adults\". The New England Journal of Medicine. 2018. 378(9):829-839.",
"title" : "Balanced Crystalloids versus Saline in Critically Ill Adults",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711584",
"pageName" : "SMART-MED and SMART-SURG",
"published" : "2018-03-01",
"expansion" : "Isotonic Solutions and Major Adverse Renal Events Trial"
},
{
"title" : "Comparison of dopamine and norepinephrine in the treatment of shock",
"citation" : "De Backer D, et al. \"Comparison of dopamine and norepinephrine in the treatment of shock\". The New England Journal of Medicine. 2010. 362(9):779-89.",
"pmid" : "20200382",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907118",
"expansion" : "Sepsis Occurrence in Acutely Ill Patients II",
"published" : "2010-03-04",
"pageName" : "SOAP II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907118",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Norepinephrine reduces mortality",
"diseases" : "Sepsis;Shock",
"abbreviation" : "SOAP II",
"briefDesignDescription" : "Dopamine vs. norepinephrine in shock",
"trainingLevel" : "Intern",
"pageid" : 113,
"timestamp" : "2017-01-19T19:50:29Z",
"subspecialties" : "Critical Care;Emergency Medicine"
},
{
"briefDesignDescription" : "Ticagrelor vs. aspirin in acute stroke or TIA",
"abbreviation" : "SOCRATES",
"trainingLevel" : "Resident",
"pageid" : 2809,
"timestamp" : "2017-12-03T22:39:15Z",
"subspecialties" : "Neurology",
"statusUsableDate" : "2016-10-01",
"briefResultsDescription" : "Ticagrelor not superior to aspirin in acute stroke or TIA",
"diseases" : "Stroke",
"published" : "2016-07-07",
"expansion" : "Ticagrelor versus aspirin in stroke/TIA",
"pageName" : "SOCRATES",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603060",
"title" : "Ticagrelor versus aspirin in acute stroke or transient ischemic attack",
"citation" : "Johnston SC, et al. \"Ticagrelor versus aspirin in acute stroke or transient ischemic attack\". New Engl J Med. 2016. 365(1):35-43.",
"pmid" : "27160892",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603060"
},
{
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:39:16Z",
"pageid" : 394,
"trainingLevel" : "Resident",
"abbreviation" : "SOLVD",
"briefDesignDescription" : "Enalapril in moderate-severe HFrEF",
"diseases" : "Heart Failure",
"briefResultsDescription" : "Enalapril reduces mortality and HF hospitalizations in HFrEF",
"statusUsableDate" : "2012-04-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199108013250501",
"pageName" : "SOLVD",
"published" : "1991-08-01",
"expansion" : "Studies of Left Ventricular Dysfunction",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199108013250501",
"pmid" : "2057034",
"citation" : "Yusuf S, et al. \"Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure\". The New England Journal of Medicine. 1991. 325(5):293-302.",
"title" : "Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure"
},
{
"trainingLevel" : "Intern",
"briefDesignDescription" : "Occult cancer screening in unprovoked VTE",
"abbreviation" : "SOME",
"subspecialties" : "Oncology;Hematology",
"timestamp" : "2018-08-30T18:21:05Z",
"pageid" : 2498,
"statusUsableDate" : "2018-08-30",
"diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
"briefResultsDescription" : "No benefit over age-appropriate screening",
"expansion" : "",
"published" : "2015-08-20",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506623",
"pageName" : "SOME",
"citation" : "Carrier M, et al. \"Screening for Occult Cancer in Unprovoked Venous Thromboembolism\". The New England Journal of Medicine. 2015. 373(8):697-704.",
"title" : "Screening for Occult Cancer in Unprovoked Venous Thromboembolism",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506623",
"pmid" : "26095467"
},
{
"expansion" : "Study of Biologic and Immunomodulator Naive Patients in Crohn's Disease",
"published" : "2010-04-15",
"pageName" : "SONIC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0904492",
"title" : "Infliximab, azathioprine, or combination therapy for Crohn's disease",
"citation" : "Colombel JF, et al. \"Infliximab, azathioprine, or combination therapy for Crohn's disease\". The New England Journal of Medicine. 2010. 362(15):1383-1395.",
"pmid" : "20393175",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0904492",
"abbreviation" : "SONIC",
"briefDesignDescription" : "Infliximab ± azathioprine induction in Crohn disease",
"trainingLevel" : "Intern",
"pageid" : 1863,
"timestamp" : "2017-12-03T22:39:17Z",
"subspecialties" : "Gastroenterology",
"statusUsableDate" : "2014-07-01",
"briefResultsDescription" : "Combination therapy better than infliximab or azathioprine for Crohn disease induction therapy",
"diseases" : "Inflammatory Bowel Disease;Crohn Disease"
},
{
"diseases" : "Chronic Pain",
"briefResultsDescription" : "Opioids without benefit over non-opioid management for chronic MSK pain",
"statusUsableDate" : "2019-06-27",
"timestamp" : "2019-06-28T16:43:02Z",
"pageid" : 3620,
"subspecialties" : "Emergency Medicine;Pain Medicine",
"abbreviation" : "SPACE",
"briefDesignDescription" : "Opioids vs. non-opioids in chronic MSK pain",
"trainingLevel" : "student",
"pdfurl" : "",
"pmid" : "29509867",
"title" : "Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain",
"citation" : "Krebs EE, et al. \"Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain\". JAMA. 2018. 319(9):872-882.",
"pageName" : "SPACE",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2018.0899",
"expansion" : "Strategies for Prescribing Analgesics Comparative Effectiveness",
"published" : "2018-06-03"
},
{
"pdfurl" : "http://circ.ahajournals.org/content/84/2/527.full.pdf",
"pmid" : "1860198",
"citation" : "SPAF Investigators. \"Stroke Prevention in Atrial Fibrillation Study. Final results\". Circulation. 1991. 84(2):527-39.",
"title" : "Stroke Prevention in Atrial Fibrillation Study. Final results",
"fulltexturl" : "http://circ.ahajournals.org/content/84/2/527.long",
"pageName" : "SPAF",
"expansion" : "Stroke Prevention in Atrial Fibrillation",
"published" : "1991-08-01",
"diseases" : "Atrial Fibrillation;Stroke",
"briefResultsDescription" : "Aspirin and warfarin reduce stroke incidence in AF",
"statusUsableDate" : "2016-08-01",
"subspecialties" : "Cardiology;Neurology",
"timestamp" : "2017-12-03T22:39:18Z",
"pageid" : 2340,
"trainingLevel" : "Resident",
"abbreviation" : "SPAF",
"briefDesignDescription" : "Aspirin and warfarin in AF"
},
{
"citation" : "Amarenco P, et al. \"High-dose atorvastatin after stroke or transient ischemic attack\". The New England Journal of Medicine. 2006. 355(6):549-559.",
"title" : "High-dose atorvastatin after stroke or transient ischemic attack",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061894",
"pmid" : "16899775",
"expansion" : "Stroke Prevention by Aggressive Reduction in Cholesterol Levels",
"published" : "2006-08-10",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061894",
"pageName" : "SPARCL",
"statusUsableDate" : "2012-06-01",
"diseases" : "Stroke;Hyperlipidemia;Transient Ischemic Attack",
"briefResultsDescription" : "Atorvastatin ↓stroke risk in general but slightly ↑hemorrhagic strokes",
"trainingLevel" : "intern",
"abbreviation" : "SPARCL",
"briefDesignDescription" : "Atorvastatin after stroke",
"subspecialties" : "Neurology",
"timestamp" : "2017-12-03T22:39:20Z",
"pageid" : 461
},
{
"diseases" : "Sedation;Delirium",
"briefResultsDescription" : "Dexmedetomidine with more adverse events vs. usual care",
"statusUsableDate" : "2020-05-14",
"timestamp" : "2021-10-26T13:55:55Z",
"pageid" : 4073,
"subspecialties" : "Critical Care",
"abbreviation" : "SPICE III",
"briefDesignDescription" : "Dexmedetomidine in ICU sedation",
"trainingLevel" : "Fellow",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1904710?articleTools",
"pmid" : "31112380",
"title" : "Early Sedation with Dexmedetomidine in Critically Ill Patients",
"citation" : "Shehabi Y, et al. \"Early Sedation with Dexmedetomidine in Critically Ill Patients\". The New England Journal of Medicine. 2019. 380(26):2506-2517.",
"pageName" : "SPICE III",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1904710",
"expansion" : "Sedation Practice in Intensive Care Evaluation",
"published" : "2019-05-19"
},
{
"pmid" : "26551272",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1511939",
"citation" : "The SPRINT Research Group. \"A randomized trial of intensive versus standard blood-pressure control\". The New England Journal of Medicine. 2015. 373(22):2103-2116.",
"title" : "A randomized trial of intensive versus standard blood-pressure control",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1511939",
"pageName" : "SPRINT",
"expansion" : "Systolic Blood Pressure Intervention Trial",
"published" : "2015-11-09",
"briefResultsDescription" : "SBP <120 improves CV outcomes with increased risks",
"diseases" : "Hypertension",
"statusUsableDate" : "2015-11-01",
"subspecialties" : "Cardiology;Preventive Medicine",
"pageid" : 2487,
"timestamp" : "2024-12-12T20:30:17Z",
"trainingLevel" : "Student",
"briefDesignDescription" : "BP targets in high-risk patients",
"abbreviation" : "SPRINT"
},
{
"pageName" : "SPS3 Clopidogrel-ASA",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1204133",
"expansion" : "Secondary Prevention of Small Subcortical Strokes clopidogrel+ASA",
"published" : "2012-08-30",
"pmid" : "22931315",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1204133",
"title" : "Effects of clopidogrel added to aspirin in patients with recent lacunar stroke",
"citation" : "SPS3 Study Group writers. \"Effects of clopidogrel added to aspirin in patients with recent lacunar stroke\". New England Journal of Medicine. 2012. 367(9):817-825.",
"pageid" : 2678,
"timestamp" : "2017-12-03T22:39:22Z",
"subspecialties" : "Neurology",
"abbreviation" : "SPS3-Clopidogrel+ASA",
"briefDesignDescription" : "Clopidogrel+ASA for lacunar strokes",
"trainingLevel" : "Intern",
"briefResultsDescription" : "Clopidogrel+ASA increased all cause mortality compared to ASA alone",
"diseases" : "Stroke;Transient Ischemic Attack",
"statusUsableDate" : "2016-06-01"
},
{
"pmid" : "23726159",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(13)60852-1.pdf",
"title" : "Blood-pressure targets in patients with recent lacunar stroke",
"citation" : "SPS3 Study Group. \"Blood-pressure targets in patients with recent lacunar stroke\". The Lancet. 2013. 382(9891):507-515.",
"pageName" : "SPS3-BP",
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60852-1/abstract",
"published" : "2013-05-29",
"expansion" : "Secondary Prevention of Small Subcortical Strokes-Blood Pressure",
"briefResultsDescription" : "No significant difference in all stroke types between two groups",
"diseases" : "Stroke",
"statusUsableDate" : "2016-01-01",
"pageid" : 2671,
"timestamp" : "2017-12-03T22:39:24Z",
"subspecialties" : "Neurology",
"briefDesignDescription" : "SBP <130 vs. SBP 130-150 after lacunar strokes",
"abbreviation" : "SPS3-BP",
"trainingLevel" : "Intern"
},
{
"timestamp" : "2018-06-29T18:11:38Z",
"pageid" : 3642,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Renal denervation in resistant hypertension",
"abbreviation" : "SPYRAL HTN-ON MED",
"trainingLevel" : "Resident",
"diseases" : "Hypertension",
"briefResultsDescription" : "Renal denervation+meds is superior to medical therapy alone in resistant hypertension",
"statusUsableDate" : "2018-06-12",
"pageName" : "SPYRAL HTN-ON MED",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30951-6/fulltext",
"expansion" : "Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy",
"published" : "2018-06-09",
"pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(18)30951-6.pdf",
"pmid" : "29803589",
"title" : "Effect of renal denervation on blood pressure in the presence of antihypertensive drugs",
"citation" : "Kandazi DE, et al. \"Effect of renal denervation on blood pressure in the presence of antihypertensive drugs\". The Lancet. 2018. 391:2346-55."
},
{
"expansion" : "Surgical Treatment and Medications Potentially Eradicate Diabetes Efficiently",
"published" : "2012-04-26",
"pageName" : "STAMPEDE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200225",
"title" : "Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes",
"citation" : "Schauer PR, et al. \"Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes\". The New England Journal of Medicine. 2012. 366(17):1567-76.",
"pmid" : "22449319",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200225",
"briefDesignDescription" : "Gastric bypass vs. medical therapy for T2DM",
"abbreviation" : "STAMPEDE",
"trainingLevel" : "Resident",
"pageid" : 2266,
"timestamp" : "2017-12-03T22:39:25Z",
"subspecialties" : "Endocrinology;Surgery",
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Bypass plus medical therapy is superior to medical therapy alone",
"diseases" : "Diabetes Mellitus;Obesity"
},
{
"citation" : "Vogel VG, et al. \"Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes\". Journal of the American Medical Association. 2006. 295(23):2727-2741.",
"title" : "Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes",
"pmid" : "16754727",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5028/JOC60074.pdf",
"expansion" : "Study of Tamoxifen and Raloxifene (NSABP P-2)",
"published" : "2006-06-21",
"fulltexturl" : "http://jama.jamanetwork.com/article.aspx?articleid",
"pageName" : "STAR",
"statusUsableDate" : "2012-08-01",
"briefResultsDescription" : "Similar reduction in breast cancer risk but fewer adverse effects with raloxifene",
"diseases" : "Breast Cancer",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Tamoxifen vs. raloxifene in breast cancer prevention",
"abbreviation" : "STAR",
"subspecialties" : "Oncology",
"pageid" : 963,
"timestamp" : "2017-12-03T22:39:26Z"
},
{
"fulltexturl" : "",
"pageName" : "STAR-D",
"published" : "2006-11-01",
"expansion" : "Sequenced Treatment Alternatives to Relieve Depression",
"pdfurl" : "http://ajp.psychiatryonline.org/data/Journals/AJP/3782/06aj1905.PDF",
"pmid" : "17074942",
"citation" : "Rush AJ et al. \"Acute and longer-term outcomes in depressed outpatient requiring one or several treatment steps: A STAR*D report\". The American Journal of Psychiatry. 2006. 163(11):1905-1917.",
"title" : "Acute and longer-term outcomes in depressed outpatient requiring one or several treatment steps: A STAR*D report",
"subspecialties" : "Psychiatry",
"timestamp" : "2017-12-03T22:39:27Z",
"pageid" : 1564,
"trainingLevel" : "Resident",
"abbreviation" : "STAR-D",
"briefDesignDescription" : "Tiered approach for depression",
"diseases" : "Depression",
"briefResultsDescription" : "Most patients achieved remission in first two steps",
"statusUsableDate" : "2013-09-01"
},
{
"briefResultsDescription" : "Intensive BP control lowers CVD events",
"diseases" : "Hypertension",
"statusUsableDate" : "2021-11-30",
"subspecialties" : "Cardiology",
"pageid" : 4446,
"timestamp" : "2023-02-04T04:10:40Z",
"trainingLevel" : "student",
"briefDesignDescription" : "Intensive BP control hypertension",
"abbreviation" : "STEP",
"pmid" : "34491661",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2111437",
"citation" : "Zhang W, et al. \"Trial of intensive blood-pressure control in older patients with hypertension\". The New England Journal of Medicine. 2021. 385(14):1268-1279.",
"title" : "Trial of intensive blood-pressure control in older patients with hypertension",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2111437",
"pageName" : "STEP",
"expansion" : "Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients",
"published" : "2021-09-30"
},
{
"expansion" : "Semaglutide Treatment Effect in People with Obesity 1",
"published" : "2021-03-18",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2032183",
"pageName" : "STEP 1",
"citation" : "Wilding JPH, et al. \"Once-Weekly Semaglutide in Adults with Overweight or Obesity\". The New England Journal of Medicine. 2021. 384(11):989-1002.",
"title" : "Once-Weekly Semaglutide in Adults with Overweight or Obesity",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2032183",
"pmid" : "33567185",
"trainingLevel" : "Resident",
"abbreviation" : "STEP 1",
"briefDesignDescription" : "Semaglutide in obesity without diabetes",
"subspecialties" : "Endocrinology",
"timestamp" : "2023-11-11T23:27:35Z",
"pageid" : 4407,
"statusUsableDate" : "2021-04-22",
"diseases" : "Obesity;Overweight",
"briefResultsDescription" : "Semaglutide led to significant weight loss vs. placebo"
},
{
"statusUsableDate" : "2025-06-19",
"diseases" : "HFpEF;Obesity",
"briefResultsDescription" : "Semaglutide better than placebo for HF events in HFpEF+obesity",
"trainingLevel" : "student",
"abbreviation" : "STEP-HFpEF",
"briefDesignDescription" : "Semaglutide in HFpEF+obesity but no DM",
"subspecialties" : "Cardiology",
"timestamp" : "2025-06-19T18:47:05Z",
"pageid" : 5605,
"citation" : "Kosiborod MN, et al. \"Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity\". The New England Journal of Medicine. 2023. 389(12):1069-1084.",
"title" : "Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2306963",
"pmid" : "37622681",
"published" : "2023-08-25",
"expansion" : "Semaglutide Treatment Effect in People with Heart Failure with Preserved Ejection Fraction",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2306963",
"pageName" : "STEP-HFpEF"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1100356",
"pageName" : "STICH",
"expansion" : "Surgical Treatment for Ischemic Heart Failure",
"published" : "2011-04-28",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1100356",
"pmid" : "21463150",
"citation" : "Velazquez EJ, et al. \"Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction\". The New England Journal of Medicine. 2011. 354(17):1607-1616.",
"title" : "Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction",
"subspecialties" : "Cardiology",
"timestamp" : "2017-12-03T22:39:28Z",
"pageid" : 471,
"trainingLevel" : "Resident",
"abbreviation" : "STICH",
"briefDesignDescription" : "CABG in ischemic HFrEF",
"diseases" : "Heart Failure;Coronary Artery Disease",
"briefResultsDescription" : "No mortality benefit with CABG vs. OMT though improved CV outcomes",
"statusUsableDate" : "2012-12-01"
},
{
"title" : "Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial",
"citation" : "Rummel MJ, et al. \"Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial\". The Lancet. 2013. 381(9873):1203-10.",
"pmid" : "23433739",
"pdfurl" : "http://bit.ly/1owpykX",
"published" : "2013-04-03",
"expansion" : "Study Group Indolent Lymphomas",
"pageName" : "StiL",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(12)61763-2",
"statusUsableDate" : "2014-06-01",
"briefResultsDescription" : "BR superior to R-CHOP in PFS, similar in OS, less toxic",
"diseases" : "Lymphoma",
"abbreviation" : "StiL",
"briefDesignDescription" : "BR vs. R-CHOP for indolent lymphomas",
"trainingLevel" : "fellow",
"pageid" : 1664,
"timestamp" : "2017-12-03T22:39:35Z",
"subspecialties" : "Oncology;Hematology"
},
{
"statusUsableDate" : "2020-01-25",
"diseases" : "Intraabdominal Infection",
"briefResultsDescription" : "Short duration non-inferior to longer duration in intraabdominal infection",
"trainingLevel" : "Intern",
"abbreviation" : "STOP-IT",
"briefDesignDescription" : "Duration of abx in intraabdominal infection",
"subspecialties" : "Infectious Disease",
"timestamp" : "2020-01-25T15:49:52Z",
"pageid" : 2424,
"citation" : "Sawyer RG, et al. \"Trial of short-course antimicrobial therapy for intraabdominal infection\". The New England Journal of Medicine. 2015. 372(21):1996-2005.",
"title" : "Trial of short-course antimicrobial therapy for intraabdominal infection",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1411162",
"pmid" : "25992746",
"expansion" : "Study to Optimize Peritoneal Infection Therapy",
"published" : "2015-05-21",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1411162",
"pageName" : "STOP-IT"
},
{
"pmid" : "12086760",
"pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(02)08905-5.pdf",
"citation" : "Chiasson JL, et al. \"Acarbose for prevention of type 2 diabetes mellitus\". The Lancet. 2005. 359(9323):2072-2077.",
"title" : "Acarbose for prevention of type 2 diabetes mellitus",
"fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08905-5/fulltext",
"pageName" : "STOP-NIDDM",
"expansion" : "Study to Prevent NIDDM",
"published" : "2002-06-15",
"briefResultsDescription" : "Acarbose reduced the risk of diabetes",
"diseases" : "Diabetes Mellitus",
"statusUsableDate" : "2023-08-03",
"subspecialties" : "Endocrinology",
"pageid" : 2754,
"timestamp" : "2023-08-03T18:09:18Z",
"trainingLevel" : "Resident",
"abbreviation" : "STOP-NIDDM",
"briefDesignDescription" : "Acarbose to prevent diabetes in high-risk patients"
},
{
"diseases" : "Alcoholic Hepatitis",
"briefResultsDescription" : "No difference between groups",
"statusUsableDate" : "2016-03-01",
"timestamp" : "2023-11-13T16:15:41Z",
"pageid" : 2365,
"subspecialties" : "Gastroenterology",
"briefDesignDescription" : "Prednisolone vs. pentoxifylline in alcoholic hepatitis",
"abbreviation" : "STOPAH",
"trainingLevel" : "Intern",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1412278",
"pmid" : "25901427",
"title" : "Prednisolone or pentoxifylline for alcoholic hepatitis",
"citation" : "Thursz MR, et al. \"Prednisolone or pentoxifylline for alcoholic hepatitis\". The New England Journal of Medicine. 2015. 372(17):1619-1628.",
"pageName" : "STOPAH",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1412278",
"expansion" : "Steroids or Pentoxifylline for Alcoholic Hepatitis",
"published" : "2015-04-23"
},
{
"fulltexturl" : "http://bit.ly/1LOZfB6",
"pageName" : "Stopping Statins at the End of Life",
"expansion" : "",
"published" : "2015-05-01",
"pmid" : "25798575",
"pdfurl" : "",
"citation" : "Kutner JS, et al. \"Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial\". JAMA Internal Medicine. 2015. 175(5):691-700.",
"title" : "Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial",
"subspecialties" : "Palliative Care;Cardiology",
"pageid" : 2432,
"timestamp" : "2017-12-03T22:39:36Z",
"trainingLevel" : "Resident",
"abbreviation" : "",
"briefDesignDescription" : "Palliative statin discontinuation",
"briefResultsDescription" : "Discontinuing statin doesn't change 60 day all-cause mortality",
"diseases" : "Hyperlipidemia",
"statusUsableDate" : "2015-09-01"
},
{
"published" : "2018-10-24",
"expansion" : "Stress Ulcer Prophylaxis in the Intensive Care Unit",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1714919",
"pageName" : "SUP-ICU",
"citation" : "Krag M, et al. \"Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU\". The New England Journal of Medicine. 2018. 379:2199-2208.",
"title" : "Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1714919",
"pmid" : "30354950",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Routine PPI use in the ICU",
"abbreviation" : "SUP-ICU",
"subspecialties" : "Critical Care",
"timestamp" : "2025-06-19T18:34:51Z",
"pageid" : 3725,
"statusUsableDate" : "2018-11-01",
"diseases" : "Stress Ulcer",
"briefResultsDescription" : "PPI doesn't reduce mortality, it reduces bleeding"
},
{
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700456",
"pageName" : "SURTAVI",
"published" : "2017-03-17",
"expansion" : "Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement",
"pmid" : "28304219",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700456",
"citation" : "Reardon MJ, et al. \"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients\". The New England Journal of Medicine. 2017. epub 2017-03-17:1-11.",
"title" : "Surgical or transcatheter aortic-valve replacement in intermediate-risk patients",
"subspecialties" : "Cardiology",
"pageid" : 2895,
"timestamp" : "2017-12-03T22:39:31Z",
"trainingLevel" : "Resident",
"abbreviation" : "SURTAVI",
"briefDesignDescription" : "TAVI for AS in intermediate-risk surgical candidates",
"briefResultsDescription" : "TAVI noninferior to surgical AVR in intermediate-risk surgical candidates",
"diseases" : "Aortic Stenosis",
"statusUsableDate" : "2017-04-01"
},
{
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1611770",
"pmid" : "27959701",
"title" : "Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease",
"citation" : "Ataga KI, et al. \"Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease\". The New England Journal of Medicine. 2017. 376(5):429-439.",
"pageName" : "SUSTAIN",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1611770",
"published" : "2017-02-02",
"expansion" : "",
"diseases" : "Sickle Cell Disease",
"briefResultsDescription" : "Crizanlizumab reduces painful crises",
"statusUsableDate" : "2020-12-31",
"timestamp" : "2021-01-05T21:10:45Z",
"pageid" : 4387,
"subspecialties" : "Hematology",
"abbreviation" : "SUSTAIN",
"briefDesignDescription" : "Crizanlizumab vs. placebo in SCD",
"trainingLevel" : "Fellow"
},
{
"statusUsableDate" : "2023-11-22",
"briefResultsDescription" : "GLP-1 lowers CVD events DM if high CVD risk",
"diseases" : "Diabetes Mellitus;Cardiovascular Disease",
"abbreviation" : "SUSTAIN-6",
"briefDesignDescription" : "GLP-1 in DM if high CVD risk",
"trainingLevel" : "Resident",
"pageid" : 2882,
"timestamp" : "2025-06-19T18:31:50Z",
"subspecialties" : "Cardiology;Endocrinology",
"title" : "Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes",
"citation" : "Marso SP, et al. \"Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes\". The New England Journal of Medicine. 2016. 375(18):1834-1844.",
"pmid" : "27633186",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1607141",
"published" : "2016-11-10",
"expansion" : "Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes",
"pageName" : "SUSTAIN-6",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1607141"
},
{
"diseases" : "Breast Cancer",
"briefResultsDescription" : "Breast cancer screening with mammogram lowers cancer mortality",
"statusUsableDate" : "2023-02-16",
"timestamp" : "2023-02-16T20:42:11Z",
"pageid" : 2435,
"subspecialties" : "Oncology;Preventive Medicine",
"briefDesignDescription" : "Mammogram screening 29y follow-up",
"abbreviation" : "Swedish Two-County Trial",
"trainingLevel" : "Student",
"pdfurl" : "http://pubs.rsna.org/doi/pdf/10.1148/radiol.11110469",
"pmid" : "21712474",
"title" : "Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades",
"citation" : "Tabar L, et al. \"Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades\". Radiology. 2011. 260(3):658-663.",
"pageName" : "Swedish Two-County Trial",
"fulltexturl" : "http://pubs.rsna.org/doi/10.1148/radiol.11110469",
"expansion" : "",
"published" : "2011-09-01"
},
{
"citation" : "Flanigan RC, et al. \"Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer\". The New England Journal of Medicine. 2001. 345(23):1655-9.",
"title" : "Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer",
"pmid" : "11759643",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa003013",
"published" : "2001-12-06",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa003013",
"pageName" : "SWOG 8949",
"statusUsableDate" : "2014-06-01",
"briefResultsDescription" : "Cytoreductive nephrectomy improves survival in mRCC",
"diseases" : "Renal Cell Carcinoma",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Cytoreductive nephrectomy in metastatic RCC",
"abbreviation" : "SWOG 8949",
"subspecialties" : "Oncology;Surgery;Urology",
"pageid" : 1845,
"timestamp" : "2024-10-03T23:36:53Z"
},
{
"pdfurl" : "http://archinte.ama-assn.org/cgi/reprint/162/10/1117.pdf",
"pmid" : "12020181",
"title" : "Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial",
"citation" : "Daeppen JB, et al. \"Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial\". Archives of Internal Medicine. 2002. 162(10):1117-21.",
"pageName" : "Symptom-Triggered Benzodiazepines in Alcohol Withdrawal",
"fulltexturl" : "http://archinte.ama-assn.org/cgi/content/full/162/10/1117",
"published" : "2002-05-27",
"expansion" : "",
"diseases" : "Alcohol Withdrawal",
"briefResultsDescription" : "Symptom-triggered therapy reduces length of hospitalization without increasing adverse event risk",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2013-03-05T21:40:49Z",
"pageid" : 116,
"subspecialties" : "Psychiatry",
"briefDesignDescription" : "Symptom-triggered therapy in alcohol withdrawal",
"abbreviation" : "",
"trainingLevel" : "Intern"
},
{
"briefResultsDescription" : "CABG reduces major CV events with 3VD or LM disease",
"diseases" : "Coronary Artery Disease",
"statusUsableDate" : "2012-06-01",
"pageid" : 525,
"timestamp" : "2017-12-03T22:39:33Z",
"subspecialties" : "Cardiology;Surgery",
"abbreviation" : "SYNTAX",
"briefDesignDescription" : "PCI vs. CABG in severe CAD",
"trainingLevel" : "Resident",
"pmid" : "19228612",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804626",
"title" : "Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease",
"citation" : "Serruys PW, et al. \"Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease\". The New England Journal of Medicine. 2009. 360(10):961-972.",
"pageName" : "SYNTAX",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804626",
"expansion" : "Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery",
"published" : "2009-03-05"
},
{
"published" : "2001-06-21",
"expansion" : "Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban",
"pageName" : "TACTICS-TIMI 18",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200106213442501",
"title" : "Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban",
"citation" : "Cannon CP, et al. \"Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban\". New England Journal of Medicine. 2001. 344(25):1879-1887.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200106213442501",
"pmid" : "11419424",
"abbreviation" : "TACTICS-TIMI 18",
"briefDesignDescription" : "Early vs. Delayed PCI for UA-NSTEMI",
"trainingLevel" : "Resident",
"timestamp" : "2020-04-01T00:34:11Z",
"pageid" : 2656,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2016-05-01",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "Early PCI improves outcomes in high-risk patients"
},
{
"published" : "2010-10-28",
"expansion" : "Tiotropium Bromide as an Alternative to Increased Inhaled Glucocorticoid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1008770",
"pageName" : "TALC",
"citation" : "Peters SP, et al. \"Tiotropium bromide step-up therapy for adults with uncontrolled asthma\". The New England Journal of Medicine. 2010. 363(18):1715-1726.",
"title" : "Tiotropium bromide step-up therapy for adults with uncontrolled asthma",
"pmid" : "20979471",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1008770",
"trainingLevel" : "Fellow",
"abbreviation" : "TALC",
"briefDesignDescription" : "Tiotropium vs. others in asthma",
"subspecialties" : "Pulmonology",
"pageid" : 2267,
"timestamp" : "2017-12-03T22:39:38Z",
"statusUsableDate" : "2015-01-01",
"briefResultsDescription" : "Adding tiotropium improves peak expiratory flow better than doubling the ICS dose",
"diseases" : "Asthma"
},
{
"briefResultsDescription" : "Intensive treatment with better disease control than late RA",
"diseases" : "Rheumatoid Arthritis",
"statusUsableDate" : "2022-08-25",
"subspecialties" : "Rheumatology",
"pageid" : 2722,
"timestamp" : "2022-08-25T20:01:42Z",
"trainingLevel" : "resident",
"briefDesignDescription" : "Intensive vs. standard treatment in early RA",
"abbreviation" : "TICORA",
"pmid" : "15262104",
"pdfurl" : "",
"citation" : "Grigor C, et al. \"Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial\". The Lancet. 2004. 364(9430):263-269.",
"title" : "Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial",
"fulltexturl" : "https://doi.org/10.1016/s0140-6736(04)16676-2",
"pageName" : "TICORA",
"published" : "2004-07-17",
"expansion" : "Tight Control of Rheumatoid Arthritis"
},
{
"statusUsableDate" : "2018-05-31",
"briefResultsDescription" : "Early PCI doesn't provide additional benefit over delayed PCI in NSTEMI and UA",
"diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
"abbreviation" : "TIMACS",
"briefDesignDescription" : "Early vs. delayed PCI in NSTEMI and UA",
"trainingLevel" : "Resident",
"pageid" : 2867,
"timestamp" : "2023-09-21T17:41:32Z",
"subspecialties" : "Cardiology",
"title" : "Early versus Delayed Invasive Intervention in Acute Coronary Syndromes",
"citation" : "Mehta SR, et al. \"Early versus Delayed Invasive Intervention in Acute Coronary Syndromes\". The New England Journal of Medicine. 2009. 360:2165-2175.",
"pmid" : "19458363",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807986",
"expansion" : "The Timing of Intervention in Acute Coronary Syndromes",
"published" : "2009-05-21",
"pageName" : "TIMACS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807986"
},
{
"published" : "2014-11-08",
"expansion" : "Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia",
"fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60793-5",
"pageName" : "TIPPS",
"citation" : "Rodger MA, et al. \"Antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia\". Lancet. 2014. 384(9955):1673-1683.",
"title" : "Antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia",
"pdfurl" : "https://reader.elsevier.com/reader/sd/pii/S0140673614607935",
"pmid" : "25066248",
"trainingLevel" : "Fellow",
"briefDesignDescription" : "Dalteparin in pregnant woman with thrombophilias",
"abbreviation" : "TIPPS",
"subspecialties" : "Hematology;Obstetrics",
"timestamp" : "2019-06-20T18:30:08Z",
"pageid" : 3718,
"statusUsableDate" : "2019-06-20",
"diseases" : "Thrombophilia;Pregnancy;Venous Thromboembolism",
"briefResultsDescription" : "Dalteparin did not reduce rate of pregnancy complications"
},
{
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa050461",
"pmid" : "15755765",
"title" : "Intensive lipid lowering with atorvastatin in patients with stable coronary disease",
"citation" : "LaRosa JC, et al. \"Intensive lipid lowering with atorvastatin in patients with stable coronary disease\". The New England Journal of Medicine. 2005. 352(14):1425-1435.",
"pageName" : "TNT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa050461",
"expansion" : "Treating to New Targets",
"published" : "2005-04-07",
"diseases" : "Coronary Artery Disease;Hyperlipidemia",
"briefResultsDescription" : "Atorvastatin 80 mg better than 10 mg for major CV events in stable CAD",
"statusUsableDate" : "2013-12-01",
"timestamp" : "2017-12-14T19:37:07Z",
"pageid" : 1762,
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Atorvastatin in stable CAD",
"abbreviation" : "TNT",
"trainingLevel" : "Student"
},
{
"pageid" : 2990,
"timestamp" : "2017-12-14T19:36:29Z",
"subspecialties" : "Cardiology",
"abbreviation" : "TONE",
"briefDesignDescription" : "Na reduction and weight loss for HTN control in elderly",
"trainingLevel" : "Student",
"briefResultsDescription" : "Na reduction and weight loss are effective means for hypertension control in the elderly",
"diseases" : "Hypertension",
"statusUsableDate" : "2017-12-14",
"pageName" : "TONE",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/vol/279/pg/839",
"published" : "1998-03-18",
"expansion" : "Trial of Nonpharmacologic Interventions in the Elderly",
"pmid" : "9515998",
"pdfurl" : "",
"title" : "Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group",
"citation" : "Whelton PK, et al. \"Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group\". JAMA. 1998. 279(11):839-846."
},
{
"published" : "2014-04-20",
"expansion" : "Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313731",
"pageName" : "TOPCAT",
"citation" : "Pitt B, et al. \"Spironolactone for heart failure with preserved ejection fraction\". The New England Journal of Medicine. 2014. 370(15):1383-1392.",
"title" : "Spironolactone for heart failure with preserved ejection fraction",
"pmid" : "24716680",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313731",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Spironolactone for HFpEF",
"abbreviation" : "TOPCAT",
"subspecialties" : "Cardiology",
"pageid" : 1797,
"timestamp" : "2024-10-23T14:44:07Z",
"statusUsableDate" : "2014-05-01",
"briefResultsDescription" : "Spironolactone doesn't reduce CV mortality, aborted cardiac arrest or HF hospitalizations in HFpEF",
"diseases" : "Heart Failure"
},
{
"briefDesignDescription" : "Platelet transfusions in blood cancers",
"abbreviation" : "TOPPS",
"trainingLevel" : "Resident",
"timestamp" : "2023-09-21T18:44:50Z",
"pageid" : 2794,
"subspecialties" : "Oncology;Hematology",
"statusUsableDate" : "2023-09-22",
"diseases" : "Thrombocytopenia",
"briefResultsDescription" : "Prophylactic platelet transfusions lower bleeding events",
"published" : "2013-05-09",
"expansion" : "Trial of Prophylactic Platelets",
"pageName" : "TOPPS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212772",
"title" : "A no-prophylaxis platelet-transfusion strategy for hematologic cancers",
"citation" : "Stanworth S, et al. \"A no-prophylaxis platelet-transfusion strategy for hematologic cancers\". The New England Journal of Medicine. 2013. 368(19):1771-1780.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212772",
"pmid" : "23656642"
},
{
"briefResultsDescription" : "Trend towards mortality benefit",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"statusUsableDate" : "2012-03-01",
"subspecialties" : "Pulmonology",
"pageid" : 124,
"timestamp" : "2015-05-29T16:40:40Z",
"trainingLevel" : "Student",
"abbreviation" : "TORCH",
"briefDesignDescription" : "Salmeterol/fluticasone in COPD",
"pmid" : "17314337",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa063070",
"citation" : "Calverley PM, et al. \"Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease\". The New England Journal of Medicine. 2007. 356(8):775-789.",
"title" : "Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa063070",
"pageName" : "TORCH",
"published" : "2007-02-22",
"expansion" : "Towards a Revolution in COPD Health"
},
{
"expansion" : "Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-III",
"published" : "2024-07-18",
"pageName" : "TRACE-III",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2402980",
"title" : "Tenecteplase for ischemic stroke at 4.5 to 24 hours without thrombectomy",
"citation" : "Xiong Y, et al. \"Tenecteplase for ischemic stroke at 4.5 to 24 hours without thrombectomy\". The New England Journal of Medicine. 2024. 391(3):203-212.",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2402980",
"pmid" : "38884324",
"briefDesignDescription" : "tPA 4.5-24h post-stroke if ideal MRI/CT",
"abbreviation" : "TRACE-III",
"trainingLevel" : "resident",
"timestamp" : "2024-08-08T20:44:43Z",
"pageid" : 5557,
"subspecialties" : "Neurology",
"statusUsableDate" : "2024-07-28",
"diseases" : "Stroke",
"briefResultsDescription" : "tPA improves recovery after stroke"
},
{
"subspecialties" : "Gastroenterology",
"pageid" : 1191,
"timestamp" : "2017-12-03T22:39:47Z",
"trainingLevel" : "Intern",
"abbreviation" : "",
"briefDesignDescription" : "Transfusion thresholds in UGIB",
"briefResultsDescription" : "Restrictive transfusions lower mortality in UGIB",
"diseases" : "Gastrointestinal Hemorrhage;Hemorrhage",
"statusUsableDate" : "2013-02-01",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211801",
"pageName" : "Transfusion Strategies for Acute Upper Gastrointestinal Bleeding",
"published" : "2013-01-03",
"expansion" : "",
"pmid" : "23281973",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211801",
"citation" : "Villanueva C et al. \"Transfusion strategies for acute upper gastrointestinal bleeding\". The New England Journal of Medicine. 2013. 368(1):11-21.",
"title" : "Transfusion strategies for acute upper gastrointestinal bleeding"
},
{
"pdfurl" : null,
"pmid" : "30002145",
"title" : "Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome",
"citation" : "Pengo V, et al. \"Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome\". Blood. 2018. 132(13):1365-1371.",
"pageName" : "TRAPS",
"fulltexturl" : "https://doi.org/10.1182/blood-2018-04-848333",
"published" : "2018-09-27",
"expansion" : "Trial on Rivaroxaban in AntiPhospholipid Syndrome",
"diseases" : "Antiphospholipid Syndrome",
"briefResultsDescription" : "Rivaroxaban inferior to warfarin in high-risk APLS",
"statusUsableDate" : "2018-10-19",
"timestamp" : "2021-05-26T13:37:31Z",
"pageid" : 3700,
"subspecialties" : "Hematology;Rheumatology",
"briefDesignDescription" : "Rivaroxaban in high-risk APLS",
"abbreviation" : "TRAPS",
"trainingLevel" : "Fellow"
},
{
"diseases" : "Chronic Kidney Disease;Anemia;Diabetes Mellitus",
"briefResultsDescription" : "No mortality benefit when targeting higher hemoglobin with ESAs in patients with CKD and T2DM",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2015-03-09T17:49:43Z",
"pageid" : 5,
"subspecialties" : "Nephrology;Hematology;Endocrinology",
"abbreviation" : "TREAT",
"briefDesignDescription" : "Darbepoetin in CKD and T2DM",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907845",
"pmid" : "19880844",
"title" : "A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease",
"citation" : "Pfeffer MA, et al. \"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease\". The New England Journal of Medicine. 2009. 361(21):2019-32.",
"pageName" : "TREAT",
"fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907845",
"published" : "2009-11-19",
"expansion" : "Trial to Reduce Cardiovascular Events With Aranesp Therapy"
},
{
"abbreviation" : "TRED-HF",
"briefDesignDescription" : "Withdrawal of medications in dilated cardiomyopathy",
"trainingLevel" : "Resident",
"timestamp" : "2019-06-27T20:30:21Z",
"pageid" : 3747,
"subspecialties" : "Cardiology",
"statusUsableDate" : "2019-06-20",
"diseases" : "Heart Failure;Dilated Cardiomyopathy",
"briefResultsDescription" : "Withdrawal of medications increases relapse of heart failure",
"expansion" : "Treatment for heart failure in patients with recovered dilated cardiomyopathy",
"published" : "2018-11-09",
"pageName" : "TRED-HF",
"fulltexturl" : "https://doi.org/10.1016/S0140-6736(18)32484-X",
"title" : "Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial",
"citation" : "Halliday BP, et al. \"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial\". The Lancet. 2019. 393(10166):61-73.",
"pdfurl" : "https://pdf.sciencedirectassets.com/271074/1-s2.0-S0140673618X00567/1-s2.0-S014067361832484X/main.pdf",
"pmid" : "30429050"
},
{
"diseases" : "Anemia",
"briefResultsDescription" : "Restrictive hemoglobin goals improved mortality",
"statusUsableDate" : "2012-03-01",
"timestamp" : "2021-08-05T17:53:04Z",
"pageid" : 104,
"subspecialties" : "Critical Care;Hematology;Transfusion Medicine",
"abbreviation" : "TRICC",
"briefDesignDescription" : "Transfusion thresholds in ICU",
"trainingLevel" : "Intern",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199902113400601",
"pmid" : "9971864",
"title" : "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care",
"citation" : "Hebert PC, et al. \"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care\". The New England Journal of Medicine. 1999. 340(6):409-417.",
"pageName" : "TRICC",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199902113400601",
"published" : "1999-02-11",
"expansion" : "Transfusion Requirements in Critical Care"
},
{
"statusUsableDate" : "2018-04-26",
"diseases" : "Anemia",
"briefResultsDescription" : "Restrictive noninferior to liberal RBC transfusions",
"trainingLevel" : "Resident",
"briefDesignDescription" : "Transfusion thresholds for cardiac surgery",
"abbreviation" : "TRICS III",
"subspecialties" : "Surgery;Hematology",
"timestamp" : "2018-04-26T17:40:38Z",
"pageid" : 3536,
"citation" : "Mazer CD, et al. \"Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery\". The New England Journal of Medicine. 2017. 377(22):2133-44.",
"title" : "Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711818",
"pmid" : "29130845",
"expansion" : "Transfusion Requirements in Cardiac Surgery",
"published" : "2017-11-30",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711818",
"pageName" : "TRICS III"
},
{
"published" : "2014-10-09",
"expansion" : "Transfusion Requirements in Septic Shock",
"pageName" : "TRISS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1406617",
"title" : "Transfusion thresholds in Septic Shock",
"citation" : "Holst L, et al. \"Transfusion thresholds in Septic Shock\". The New England Journal of Medicine. 2014. 371(15):1381-1391.",
"pmid" : "25270275",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1406617",
"briefDesignDescription" : "Transfusion thresholds in sepsis",
"abbreviation" : "TRISS",
"trainingLevel" : "Intern",
"pageid" : 2268,
"timestamp" : "2022-12-01T19:01:46Z",
"subspecialties" : "Critical Care;Hematology",
"statusUsableDate" : "2014-12-01",
"briefResultsDescription" : "Similar mortality; Fewer transfusions with restrictive",
"diseases" : "Sepsis;Shock;Anemia"
},
{
"citation" : "Wiviott ST, et al. \"Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes\". The New England Journal of Medicine. 2007. 357(20):2001-2015.",
"title" : "Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes",
"pmid" : "17982182",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482",
"published" : "2007-11-15",
"expansion" : "Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel–Thrombolysis in Myocardial Infarction 38",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706482",
"pageName" : "TRITON-TIMI 38",
"statusUsableDate" : "2013-04-01",
"briefResultsDescription" : "Prasugrel decreases CV mortality/morbidity, increases bleeding",
"diseases" : "Acute Coronary Syndrome",
"trainingLevel" : "Resident",
"abbreviation" : "TRITON-TIMI 38",
"briefDesignDescription" : "Prasugrel vs. clopidogrel in ACS",
"subspecialties" : "Cardiology",
"pageid" : 1398,
"timestamp" : "2017-12-03T22:39:43Z"
},
{
"citation" : "Hillmen P, et al. \"The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria\". The New England Journal of Medicine. 2006. 355(12):1233-1243.",
"title" : "The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria",
"pmid" : "16990386",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061648",
"published" : "2006-09-21",
"expansion" : "Transfusion Reduction Efficacy and Safety Clinical Investigation, a Randomized, Multicenter, Double-Blind, Placebo-Controlled, Using Eculizumab in Paroxysmal Nocturnal Hemoglobinuria",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061648",
"pageName" : "TRIUMPH",
"statusUsableDate" : "2017-08-01",
"briefResultsDescription" : "Eculizumab decreases transfusion requirements in PNH",
"diseases" : "Paroxysmal Nocturnal Hemoglobinuria",
"trainingLevel" : "Intern",
"abbreviation" : "TRIUMPH",
"briefDesignDescription" : "Eculizumab in PNH",
"subspecialties" : "Hematology",
"pageid" : 2810,
"timestamp" : "2017-12-03T22:39:45Z"
},
{
"pageName" : "TTM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310519",
"published" : "2014-03-19",
"expansion" : "Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest",
"pmid" : "24237006",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310519",
"title" : "Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest",
"citation" : "Nielsen N, et al. \"Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest\". The New England Journal of Medicine. 2013. 369(23):2197-2206.",
"pageid" : 1783,
"timestamp" : "2017-12-03T22:39:46Z",
"subspecialties" : "Cardiology;Neurology;Critical Care",
"briefDesignDescription" : "33 vs. 36°C body temperature after cardiac arrest",
"abbreviation" : "TTM",
"trainingLevel" : "Resident",
"briefResultsDescription" : "33°C cooling provides no survival benefit over 36°C",
"diseases" : "Cardiac Arrest",
"statusUsableDate" : "2014-03-01"
},
{
"timestamp" : "2023-04-13T17:09:26Z",
"pageid" : 4433,
"subspecialties" : "Emergency Medicine;Critical Care;Cardiology",
"abbreviation" : "TTM2",
"briefDesignDescription" : "33°C vs. normothermia after cardiac arrest",
"trainingLevel" : "resident",
"diseases" : "Cardiac Arrest",
"briefResultsDescription" : "No difference in survival or functional outcomes",
"statusUsableDate" : "2021-07-30",
"pageName" : "TTM2",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2100591",
"published" : "2021-06-17",
"expansion" : "Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest 2",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2100591",
"pmid" : "34133859",
"title" : "Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest",
"citation" : "Dankiewicz J, et al. \"Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest\". The New England Journal of Medicine. 2021. 384(24):2283-2294."
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Twice-daily RT in limited SCLC",
"abbreviation" : "",
"subspecialties" : "Oncology;Pulmonology;Radiation Oncology",
"pageid" : 1773,
"timestamp" : "2017-12-03T22:39:48Z",
"statusUsableDate" : "2013-12-01",
"briefResultsDescription" : "Twice-daily RT with better response, PFS, survival than once-daily RT for limited SCLC",
"diseases" : "Lung Cancer",
"published" : "1999-01-28",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199901283400403",
"pageName" : "Twice-daily RT for SCLC",
"citation" : "Turrisi AT, et al. \"Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide\". The New England Journal of Medicine. 1999. 340(4):265-271.",
"title" : "Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide",
"pmid" : "9920950",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199901283400403"
},
{
"briefDesignDescription" : "TXA vs. packing for antiplatelet agent-related epistaxis",
"abbreviation" : "",
"trainingLevel" : "Student",
"pageid" : 3564,
"timestamp" : "2023-09-22T22:59:11Z",
"subspecialties" : "Emergency Medicine",
"statusUsableDate" : "2023-09-21",
"briefResultsDescription" : "TXA improved bleeding cessation time, rebleeding risk, and patient satisfaction",
"diseases" : "Epistaxis",
"published" : "2018-03-01",
"expansion" : "",
"pageName" : "TXA for Epistaxis Associated with Antiplatelet Agents",
"fulltexturl" : "https://onlinelibrary.wiley.com/doi/abs/10.1111/acem.13345",
"title" : "Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial",
"citation" : "Zahed R. \"Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial\". Academic Emergency Medicine. 2018. 25(3):261-266.",
"pmid" : "29125679",
"pdfurl" : "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acem.13345"
},
{
"subspecialties" : "Endocrinology",
"timestamp" : "2022-08-27T02:08:15Z",
"pageid" : 253,
"trainingLevel" : "Intern",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"abbreviation" : "UKPDS",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Reduction in microvascular complications",
"statusUsableDate" : "2012-03-01",
"fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140673698070196",
"pageName" : "UKPDS 33",
"published" : "1998-09-12",
"expansion" : "United Kingdom Prospective Diabetes Study",
"pdfurl" : "",
"pmid" : "9742976",
"citation" : "Turner R, et al. \"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes\". The Lancet. 1998. 352(9131):837-53.",
"title" : "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes"
},
{
"fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2898%2907037-8/fulltext",
"pageName" : "UKPDS 34",
"expansion" : "UK Prospective Diabetes Study 34",
"published" : "1998-11-07",
"pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673698070378.pdf",
"pmid" : "9742977",
"citation" : "UKPDS Study Group. \"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.\". The Lancet. 1998. 352(9131):854-865.",
"title" : "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.",
"subspecialties" : "Endocrinology",
"timestamp" : "2017-12-03T22:39:50Z",
"pageid" : 1747,
"trainingLevel" : "Intern",
"abbreviation" : "UKPDS 34",
"briefDesignDescription" : "Metformin in T2DM",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "Metformin better than diet alone in T2DM",
"statusUsableDate" : "2014-01-01"
},
{
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Decreased exacerbations and mortality",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"abbreviation" : "UPLIFT",
"briefDesignDescription" : "Tiotropium in COPD",
"trainingLevel" : "Resident",
"pageid" : 123,
"timestamp" : "2012-10-29T23:28:48Z",
"subspecialties" : "Pulmonology",
"title" : "A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease",
"citation" : "Tashkin DP, et al. \"A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease\". The New England Journal of Medicine. 2008. 395(15):1543-1554.",
"pmid" : "18836213",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805800",
"expansion" : "Understanding Potential Long-Term Impacts on Function with Tiotropium",
"published" : "2008-10-09",
"pageName" : "UPLIFT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805800"
},
{
"pageName" : "V-HeFT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198606123142404",
"published" : "1986-06-12",
"expansion" : "Vasodilator Heart Failure Trial",
"pmid" : "3520315",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198606123142404",
"title" : "Effect of vasodilator therapy on mortality in chronic congestive heart failure",
"citation" : "Cohn JN, et al. \"Effect of vasodilator therapy on mortality in chronic congestive heart failure\". The New England Journal of Medicine. 1986. 314(24):1547-52.",
"pageid" : 155,
"timestamp" : "2017-12-03T22:39:51Z",
"subspecialties" : "Cardiology",
"briefDesignDescription" : "ISDN/hydralazine in HFrEF",
"abbreviation" : "V-HeFT",
"trainingLevel" : "student",
"briefResultsDescription" : "Trend towards mortality benefit in ISDN/hydralazine",
"diseases" : "Heart Failure",
"statusUsableDate" : "2012-12-01"
},
{
"statusUsableDate" : "2017-11-01",
"briefResultsDescription" : "Enalapril improves survival in HFrEF",
"diseases" : "Heart Failure",
"abbreviation" : "V-HeFT II",
"briefDesignDescription" : "Enalapril vs. ISDN/hydralazine in HFrEF",
"trainingLevel" : "Student",
"pageid" : 2943,
"timestamp" : "2018-04-13T13:08:04Z",
"subspecialties" : "Cardiology",
"title" : "A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure",
"citation" : "Cohn JN, et al. \"A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure\". The New England Journal of Medicine. 1991. 325(5):303-310.",
"pmid" : "2057035",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199108013250502",
"expansion" : "Vasodilator Heart Failure Trial II",
"published" : "1991-08-01",
"pageName" : "V-HeFT II",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199108013250502"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Aspirin in unstable angina",
"abbreviation" : null,
"subspecialties" : "Cardiology",
"pageid" : 261,
"timestamp" : "2014-09-24T22:23:54Z",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Aspirin decreases mortality",
"diseases" : "Acute Coronary Syndrome",
"published" : "1983-08-18",
"expansion" : null,
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198308183090703",
"pageName" : "VA Cooperative Study",
"citation" : "Lewis HD, et al. \"Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study\". The New England Journal of Medicine. 1983. 309(7):396-403.",
"title" : "Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study",
"pmid" : "6135989",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198308183090703"
},
{
"diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
"briefResultsDescription" : "ACE+ARB no more effective than monotherapy, increases complications",
"statusUsableDate" : "2014-05-01",
"timestamp" : "2018-01-11T18:14:18Z",
"pageid" : 1798,
"subspecialties" : "Nephrology;Endocrinology",
"abbreviation" : "VA NEPHRON-D",
"briefDesignDescription" : "ACE+ARB in DM nephropathy",
"trainingLevel" : "Resident",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1303154",
"pmid" : "24206457",
"title" : "Combined angiotensin inhibition for the treatment of diabetic nephropathy",
"citation" : "Fried LF, et al. \"Combined angiotensin inhibition for the treatment of diabetic nephropathy\". The New England Journal of Medicine. 2013. 369(20):1892-1903.",
"pageName" : "VA-NEPHRON D",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1303154",
"expansion" : "Veterans Affairs Nephropathy in Diabetes",
"published" : "2013-11-14"
},
{
"title" : "Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes",
"citation" : "Duckworth W, et al. \"Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes\". The New England Journal of Medicine. 2009. 360(2):129-39.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0808431",
"pmid" : "19092145",
"published" : "2009-01-08",
"expansion" : "Veterans Affairs Diabetes Trial",
"pageName" : "VADT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0808431",
"statusUsableDate" : "2012-03-01",
"diseases" : "Diabetes Mellitus",
"briefResultsDescription" : "No effect on macrovascular or severe microvascular outcomes",
"abbreviation" : "VADT",
"briefDesignDescription" : "Intensive glycemic therapy in T2DM",
"trainingLevel" : "Resident",
"timestamp" : "2018-08-12T16:18:00Z",
"pageid" : 254,
"subspecialties" : "Endocrinology"
},
{
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "No mortality benefit of valsartan in NYHA II-IV HF",
"diseases" : "Heart Failure",
"trainingLevel" : "Resident",
"abbreviation" : "Val-HeFT",
"briefDesignDescription" : "Valsartan in HFrEF",
"subspecialties" : "Cardiology",
"pageid" : 20,
"timestamp" : "2014-08-24T17:55:57Z",
"citation" : "Cohn JN, et al. \"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure\". New England Journal of Medicine. 2001. 345(23):1667-75.",
"title" : "A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure",
"pmid" : "11759645",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010713",
"published" : "2001-12-06",
"expansion" : "Valsartan Heart Failure Trial",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010713",
"pageName" : "Val-HeFT"
},
{
"published" : "2014-05-22",
"expansion" : "",
"pageName" : "VALENCE",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1316145",
"title" : "Sofosbuvir and ribavirin in HCV genotypes 2 and 3",
"citation" : "Zeuzem S, et al. \"Sofosbuvir and ribavirin in HCV genotypes 2 and 3\". The New England Journal of Medicine. 2014. 370(21):1993-2001.",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1316145",
"pmid" : "24795201",
"abbreviation" : "VALENCE",
"briefDesignDescription" : "Sofosbuvir+ribavirin for HCV genotypes 2 or 3",
"trainingLevel" : "Student",
"timestamp" : "2017-12-03T22:39:54Z",
"pageid" : 2261,
"subspecialties" : "Infectious Disease;Gastroenterology",
"statusUsableDate" : "2014-12-01",
"diseases" : "Hepatitis C",
"briefResultsDescription" : "Sofosbuvir+ribavirin effective without IFN"
},
{
"pageid" : 462,
"timestamp" : "2019-04-11T17:06:09Z",
"subspecialties" : "Cardiology",
"abbreviation" : "VALIANT",
"briefDesignDescription" : "Valsartan vs. captopril in MI with LV dysfunction",
"trainingLevel" : "Resident",
"briefResultsDescription" : "Valsartan as effective as captopril",
"diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
"statusUsableDate" : "2012-03-01",
"pageName" : "VALIANT",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa032292",
"expansion" : "Valsartan in Acute Myocardial Infarction Trial",
"published" : "2003-11-13",
"pmid" : "12921816",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa032292",
"title" : "Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both",
"citation" : "Pfeffer MA, et al. \"Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both\". The New England Journal of Medicine. 2003. 349(20):1893-1903."
},
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"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Vancomycin is superior to metronidazole in severe C. difficile-associated diarrhea",
"diseases" : "Clostridium difficile",
"briefDesignDescription" : "Vancomycin vs. metronidazole in C. difficile",
"abbreviation" : null,
"trainingLevel" : "Intern",
"pageid" : 6,
"timestamp" : "2025-07-26T15:24:13Z",
"subspecialties" : "Infectious Disease;Gastroenterology",
"title" : "A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity",
"citation" : "Zar FA, et al. \"A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity\". Clinical Infectious Diseases. 2007. 45(3):302-7.",
"pmid" : "17599306",
"pdfurl" : "http://cid.oxfordjournals.org/content/45/3/302.full.pdf",
"expansion" : null,
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"pageName" : "Vancomycin vs. Metronidazole in C. difficile Diarrhea",
"fulltexturl" : "http://cid.oxfordjournals.org/content/45/3/302.long"
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{
"pmid" : "27149033",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1513614",
"title" : "Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs",
"citation" : "Sapp JL, et al. \"Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs\". The New England Journal of Medicine. 2016. 375(2):111-121.",
"pageName" : "VANISH",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1513614",
"published" : "2016-05-05",
"expansion" : "Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs",
"briefResultsDescription" : "VT ablation superior to escalation of antiarrhythmic drugs",
"diseases" : "Ventricular Tachycardia",
"statusUsableDate" : "2016-06-01",
"pageid" : 2783,
"timestamp" : "2017-12-03T22:39:56Z",
"subspecialties" : "Cardiology",
"briefDesignDescription" : "Ablation vs. antiarrhythmic drugs in VT",
"abbreviation" : "VANISH",
"trainingLevel" : "Resident"
},
{
"statusUsableDate" : "2014-08-01",
"briefResultsDescription" : "Vasopressin doesn't reduce mortality in shock",
"diseases" : "Sepsis;Shock",
"abbreviation" : "VASST",
"briefDesignDescription" : "Vasopressin in septic shock",
"trainingLevel" : "Resident",
"pageid" : 1910,
"timestamp" : "2020-11-22T18:00:12Z",
"subspecialties" : "Critical Care",
"title" : "Vasopressin versus norepinephrine infusion in patients with septic shock",
"citation" : "Russel JA, et al. \"Vasopressin versus norepinephrine infusion in patients with septic shock\". The New England Journal of Medicine. 2008. 358(9):877-887.",
"pmid" : "18305265",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067373",
"expansion" : "Vasopressin and Septic Shock Trial",
"published" : "2008-02-28",
"pageName" : "VASST",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067373"
},
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"pmid" : "30280654",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800781",
"title" : "Wearable cardioverter-defibrillator after myocardial infarction",
"citation" : "Olgin JE, et al. \"Wearable cardioverter-defibrillator after myocardial infarction\". The New England Journal of Medicine. 2018. 379(13):1205-1215.",
"pageName" : "VEST",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800781",
"expansion" : "Vest Prevention of Early Sudden Death",
"published" : "2018-09-27",
"briefResultsDescription" : "Wearable cardioverter-defibrillator doesn't reduce arrhythmic death",
"diseases" : "Sudden Cardiac Death",
"statusUsableDate" : "2018-10-11",
"pageid" : 3716,
"timestamp" : "2019-10-17T17:47:55Z",
"subspecialties" : "Cardiology",
"abbreviation" : "VEST",
"briefDesignDescription" : "Wearable cardioverter-defibrillator post-MI",
"trainingLevel" : "Resident"
},
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"title" : "A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus",
"citation" : "Veterans Affairs Status Epilepticus Cooperative Study Group. \"A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus\". New England Journal of Medicine. 1998. 339(12):792-798.",
"pmid" : "9738086",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJM199809173391202",
"published" : "1998-09-17",
"expansion" : "",
"pageName" : "Veterans Affairs Status Epilepticus Cooperative Study Group",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199809173391202",
"statusUsableDate" : "2022-12-20",
"briefResultsDescription" : "No difference between four antiepileptics",
"diseases" : "Epilepsy",
"abbreviation" : "Veterans Affairs Status Epilepticus Study",
"briefDesignDescription" : "Antiepileptics in status epilepticus",
"trainingLevel" : "Intern",
"pageid" : 2461,
"timestamp" : "2022-12-21T16:29:52Z",
"subspecialties" : "Neurology"
},
{
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1811403",
"pageName" : "VITAL (Omega-3 arm)",
"expansion" : "Vitamin D and Omega-3 Trial",
"published" : "2019-01-03",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1811403",
"pmid" : "30415637",
"citation" : "Manson JE, et al. \"Marine n-3 fatty acids and prevention of cardiovascular disease and cancer\". The New England Journal of Medicine. 2019. 2019(380):1.",
"title" : "Marine n-3 fatty acids and prevention of cardiovascular disease and cancer",
"subspecialties" : "Cardiology;Oncology",
"timestamp" : "2024-02-22T20:28:09Z",
"pageid" : 4179,
"trainingLevel" : "resident",
"briefDesignDescription" : "Omega-3 FA for CV and cancer prevention",
"abbreviation" : "VITAL",
"diseases" : "Cardiovascular Disease;Cancer",
"briefResultsDescription" : "Omega-3 FA did not lower CV or cancer events",
"statusUsableDate" : "2024-02-22"
},
{
"trainingLevel" : "resident",
"briefDesignDescription" : "Vitamin D for cancer or CVD prevention",
"abbreviation" : "VITAL",
"subspecialties" : "Cardiology;Oncology",
"timestamp" : "2022-12-15T19:57:40Z",
"pageid" : 4039,
"statusUsableDate" : "2022-12-14",
"diseases" : "Cardiovascular Disease;Cancer",
"briefResultsDescription" : "Vitamin D doesn't lower cancer or CVD risk",
"expansion" : "VITamin D and OmegA-3 TriaL",
"published" : "2019-01-03",
"fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa1809944",
"pageName" : "VITAL (Vitamin D arm)",
"citation" : "Manson JE, et al. \"Vitamin D supplements and prevention of cancer and cardiovascular disease\". The New England Journal of Medicine. 2019. 380(1):33-44.",
"title" : "Vitamin D supplements and prevention of cancer and cardiovascular disease",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1809944",
"pmid" : "30415629"
},
{
"trainingLevel" : "Resident",
"briefDesignDescription" : "Vitamin C, hydrocortisone, & thiamine in septic shock",
"abbreviation" : "VITAMINS",
"subspecialties" : "Critical Care",
"timestamp" : "2025-06-19T18:34:21Z",
"pageid" : 4192,
"statusUsableDate" : "2020-09-03",
"diseases" : "Sepsis;Shock",
"briefResultsDescription" : "No difference with triple-therapy in septic shock",
"published" : "2020-02-04",
"expansion" : "The VitamIn C, HydrocorTisone and ThiAMINe in Patients With Septic Shock Trial",
"fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.22176",
"pageName" : "VITAMINS",
"citation" : "Fujii T, et al. \"Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial\". JAMA. 2020. 323(5):423-431.",
"title" : "Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial",
"pdfurl" : "",
"pmid" : "31950979"
},
{
"citation" : "Bonaca M, et al. \"Rivaroxaban in Peripheral Artery Disease after Revascularization\". The New England Journal of Medicine. 2020. 382(21):1994-2004.",
"title" : "Rivaroxaban in Peripheral Artery Disease after Revascularization",
"pmid" : "32222135",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2000052",
"expansion" : null,
"published" : "2020-05-21",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2000052",
"pageName" : "VOYAGER-PAD",
"statusUsableDate" : "2023-04-20",
"briefResultsDescription" : "Low-dose rivaroxaban lowers PAD events",
"diseases" : "Peripheral Artery Disease",
"trainingLevel" : "resident",
"briefDesignDescription" : "Rivaroxaban 2.5mg BID in PAD",
"abbreviation" : "VOYAGER",
"subspecialties" : "Cardiology",
"pageid" : 5305,
"timestamp" : "2024-08-28T14:43:50Z"
},
{
"citation" : "Thomalla G, et al. \"MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset\". New England Journal of Medicine. 2018. 379(7):611-622.",
"title" : "MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset",
"pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1804355",
"pmid" : "29766770",
"expansion" : "",
"published" : "2018-08-16",
"fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1804355",
"pageName" : "WAKE-UP",
"statusUsableDate" : "2024-07-15",
"diseases" : "Stroke",
"briefResultsDescription" : "tPA >4.5 with improved outcomes post-stroke if ideal MRI",
"trainingLevel" : "Student",
"abbreviation" : "WAKE-UP",
"briefDesignDescription" : "tPA if stroke >4.5h and ideal MRI",
"subspecialties" : "Neurology",
"timestamp" : "2024-08-09T09:57:23Z",
"pageid" : 3723
},
{
"statusUsableDate" : "2013-03-01",
"briefResultsDescription" : "Aspirin reduces recurrent VTE",
"diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
"trainingLevel" : "resident",
"briefDesignDescription" : "Aspirin after VTE treatment",
"abbreviation" : "WARFASA",
"subspecialties" : "Hematology",
"pageid" : 1244,
"timestamp" : "2017-12-03T22:39:59Z",
"citation" : "Becattini C, et al. \"Aspirin for preventing the recurrence of venous thromboembolism\". The New England Journal of Medicine. 2012. 366(21):1959-1967.",
"title" : "Aspirin for preventing the recurrence of venous thromboembolism",
"pmid" : "22621626",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1114238",
"published" : "2012-05-24",
"expansion" : "Warfarin and Aspirin",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1114238",
"pageName" : "WARFASA"
},
{
"briefResultsDescription" : "Warfarin did not reduce rates of death/stroke, caused more bleeding",
"diseases" : "Stroke",
"statusUsableDate" : "2022-03-10",
"pageid" : 2784,
"timestamp" : "2022-03-10T20:02:17Z",
"subspecialties" : "Neurology",
"briefDesignDescription" : "Aspirin vs. warfarin in ischemic stroke",
"abbreviation" : "WARSS",
"trainingLevel" : "Intern",
"pmid" : "11794192",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011258",
"title" : "A Comparison of Warfarin and Aspirin for the Prevention of Recurrent Ischemic Stroke",
"citation" : "Mohr J, et al. \"A Comparison of Warfarin and Aspirin for the Prevention of Recurrent Ischemic Stroke\". The New England Journal of Medicine. 2001. 345(20):1444-1451.",
"pageName" : "WARSS",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011258",
"expansion" : "Warfarin–Aspirin Recurrent Stroke Study",
"published" : "2001-11-15"
},
{
"trainingLevel" : "Intern",
"abbreviation" : "WASID",
"briefDesignDescription" : "Warfarin vs. aspirin for intracranial atherosclerosis",
"subspecialties" : "Neurology;Cardiology",
"timestamp" : "2019-06-27T17:24:44Z",
"pageid" : 2427,
"statusUsableDate" : "2019-06-27",
"diseases" : "Stroke",
"briefResultsDescription" : "Warfarin had higher adverse events",
"expansion" : "Warfarin-Aspirin Symptomatic Intracranial Disease",
"published" : "2005-03-31",
"fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043033",
"pageName" : "WASID",
"citation" : "Chimowitz MI, et al. \"Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis\". The New England Journal of Medicine. 2005. 352(13):1305-1306.",
"title" : "Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043033",
"pmid" : "15800226"
},
{
"pageid" : 1507,
"timestamp" : "2017-12-03T22:40:01Z",
"subspecialties" : "Gynecology;Endocrinology",
"abbreviation" : "WHI E+P",
"briefDesignDescription" : "Postmenopausal estrogen/progesterone",
"trainingLevel" : "Student",
"briefResultsDescription" : "Postmenopausal estrogen/progesterone HRT increases rates of MI and breast cancer",
"diseases" : "Coronary Artery Disease;Menopause",
"statusUsableDate" : "2013-07-01",
"pageName" : "WHI",
"fulltexturl" : null,
"published" : "2002-07-17",
"expansion" : "Women's Health Initiative Estrogen and Progestin Trial",
"pmid" : "12117397",
"pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4840/JOC21036.pdf",
"title" : "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial",
"citation" : "Rossouw JE, et al. \"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial\". The Journal of the American Medical Association. 2002. 288(3):321-333."
},
{
"pmid" : "25196117",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407154",
"title" : "Withdrawal of inhaled glucocorticoids and exacerbations of COPD",
"citation" : "Magnussen H, et al. \"Withdrawal of inhaled glucocorticoids and exacerbations of COPD\". The New England Journal of Medicine. 2014. 371(14):1285-1295.",
"pageName" : "WISDOM",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407154",
"published" : "2014-10-02",
"expansion" : "Withdrawal of Inhaled Steroids during Optimized Bronchodilator Management",
"briefResultsDescription" : "ICS withdrawal may reduce FEV1, no change in COPD flares",
"diseases" : "Chronic Obstructive Pulmonary Disease",
"statusUsableDate" : "2015-05-01",
"pageid" : 2318,
"timestamp" : "2017-12-03T22:40:03Z",
"subspecialties" : "Pulmonology",
"abbreviation" : "WISDOM",
"briefDesignDescription" : "ICS withdrawal in COPD",
"trainingLevel" : "Resident"
},
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"pageName" : "WOEST",
"fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0140673612621771",
"published" : "2013-03-30",
"expansion" : "What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing",
"pdfurl" : "",
"pmid" : "23415013",
"title" : "Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial",
"citation" : "Dewilde WJM, et al. \"Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial\". The Lancet. 2013. 381(9872):1107-1115.",
"timestamp" : "2017-12-03T22:40:05Z",
"pageid" : 1792,
"subspecialties" : "Cardiology;Hematology",
"abbreviation" : "WOEST",
"briefDesignDescription" : "Clopidogrel ± ASA after PCI if on OAC",
"trainingLevel" : "Resident",
"diseases" : "Coronary Artery Disease",
"briefResultsDescription" : "ASA increases bleeding when added to clopidogrel if chronic OAC",
"statusUsableDate" : "2015-06-01"
},
{
"trainingLevel" : "Resident",
"abbreviation" : "WOSCOPS",
"briefDesignDescription" : "Pravastatin in CAD",
"subspecialties" : "Cardiology",
"pageid" : 172,
"timestamp" : "2014-12-12T19:39:51Z",
"statusUsableDate" : "2012-03-01",
"briefResultsDescription" : "Pravastatin reduces MIs and CV mortality",
"diseases" : "Hyperlipidemia;Coronary Artery Disease",
"published" : "1995-11-16",
"expansion" : "West of Scotland Coronary Prevention Study",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199511163332001",
"pageName" : "WOSCOPS",
"citation" : "Shepherd J, et al. \"Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia\". The New England Journal of Medicine. 1995. 333(20):1301-1308.",
"title" : "Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia",
"pmid" : "7566020",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199511163332001"
},
{
"statusUsableDate" : "2013-01-01",
"diseases" : "Critical Illness",
"briefResultsDescription" : "RSBI predicts success and failure of weaning from mechanical ventilation",
"trainingLevel" : "Resident",
"briefDesignDescription" : "RSBI for predicting weaning",
"abbreviation" : "",
"subspecialties" : "Pulmonology;Critical Care",
"timestamp" : "2017-12-03T22:40:06Z",
"pageid" : 75,
"citation" : "Yang KL, Tobin MJ. \"A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation\". The New England Journal of Medicine. 1991. 324(21):1445-1450.",
"title" : "A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation",
"pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199105233242101",
"pmid" : "2023603",
"published" : "1991-05-23",
"expansion" : "",
"fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199105233242101",
"pageName" : "Yang-Tobin Study"
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],
"topic" : "all"
}
}