In patients at high risk for CV disease, does a Mediterranean diet enriched with extra-virgin olive oil or nuts reduce MI, CVA, or CV death compared to a low-fat diet?
A Mediterranean diet with extra-virgin olive oil or nuts reduces rates of MI, CVA, or CV death in those at high risk for CV disease. This outcome was driven by reduction in rates of CVA.
Epidemiologic trials from the 1960s suggested that a so-called "Mediterranean diet" rich in fresh fruits, vegetables, fish, olive oil, and wine, was associated with decreased rates of CV disease. Multiple studies have demonstrated a mortality benefit from a Mediterranean or Mediterranean-like diet after MI, including DART (1989) and the Cardioprotective Diet Study (1992). Most recently, the Lyon Diet Heart Study (1999) demonstrated that a Mediterranean diet reduced recurrent CV events by 50-70% among MI patients. The role of the Mediterranean diet in primary prevention of CV disease hadn't been well established.
The 2013 Prevención con Dieta Mediterránea (Prevention with Mediterranean Diet; PREDIMED) trial randomized 7,447 Spanish patients at high risk for CVD to one of three diets: 1) a Mediterranean diet supplemented with extra-virgin olive oil, 2) a Mediterranean diet supplemented with nuts, or 3) a control diet encouraging low-fat items. The trial was terminated early after a median follow-up of 4.8 years, and demonstrated that both Mediterranean diet groups reached a statistically significant reduction in the rate of the composite primary outcome of MI, CVA, or CV death. This corresponded to an absolute reduction in three CV events per 1000 patient-years, or a 30% relative risk reduction. However, of the individual components of the primary outcome, only rate of CVA was significantly reduced.
Of note, the Look AHEAD trial (published later in 2013) randomized 5,145 overweight or obese patients with type 2 diabetes to an intensive weight loss intervention through increased exercise and caloric restriction (with <30% of total calories from fat) or an intervention focusing on general support and education about the management of T2DM. The intensive group had an increased rate of weight loss though did not have any difference in the rate of CVD or its complications at ~10 years of follow-up. While this trial did not directly address the role of a Mediterranean diet in T2DM, this diet has emerged as a potential therapy for glycemic control in diabetics. A 2014 trial by Esposito found that newly-diagnosed diabetic patients assigned to a Mediterranean diet had a longer duration of time until initiation of hypoglycemic medications than those assigned to a control diet.
- Weight loss for all overweight or obese patients with T2DM (level A)
- Weight loss in the above population is likely effective at two years with a low-carbohydrate, low-fat calorie restricted, or Mediterranean diet (level A)
- Multicenter, prospective, randomized, controlled trial
- N=7,447 patients at high risk for CVD
- Mediterranean diet with olive oil (n=2,543)
- Mediterranean diet with nuts (n=2,454)
- Low-fat control diet (n=2,450)
- Setting: Multiple Spanish centers
- Enrollment: 2003-2010
- Median follow-up: 4.8 years
- Analysis: Intention-to-treat
- Primary outcome: Composite of MI, CVA, or CV death
- Men 55-80 years or women 60-80 years in age without CVD
- DM or ≥3 of the following:
- LDL ≥160 mg/dL
- HDL ≤40 mg/dL (HDL ≥60 is protective and cancels one other risk factor)
- BMI ≥25 kg/m2
- First degree relative with CVD before 55 years (male) or 65 years (female)
- Established CVD
- Expected survival <1 year
- HIV or other immunodeficiency
- Use of illicit drugs
- Alcoholism, alcohol abuse, or daily EtOH intake > 80 g
- BMI >40 kg/m2
- Medical condition precluding participation
- Difficulties or major inconvenience to change dietary habits
- Inability to follow Mediterranean diet (eg religious reasons, chewing abnormalities)
- Low likelihood of dietary change from Prochaska and DiClemente model
- Allergy or hypersensitivity to diet food
- Other investigational trials in the last year
- Institutionalization, lacking autonomy, unable to ambulate, no stable address, unable to come to the outpatient clinic every 3 months
- Acute infection until resolved for 3 months
From the Mediterranean diet with olive oil group.
- Demographics: Age 67 years, female 58.7%, white 97.1%
- Health data: BMI 30, waist circumference 100 cm, Waist:Height 0.63
- PMH: HTN 82.1%, T2DM 50.4%, HLD 71.6%
- Family history of premature CVD: 22.7%
- Smoking history:
- Never: 61.8%
- Former: 24.3%
- Current: 13.9%
- Medications: ACE inhibitor 48.6%, diuretic 21.0%, other antihypertensive 28.5%, statin 40.9%, non-statin lipid medication 4.8%, insulin 4.9%, oral hypoglycemics 30.2%, antiplatelet 18.7%, HRT 2.8%
- Patients were randomized to one of three groups:
- Mediterranean diet with extra-virgin olive oil
- Mediterranean diet with nuts
- Low-fat control diet
- Mediterranean diet group participants had individual and group dietary training sessions four times yearly:
- Dietitians insisted that at least two meals per day be eaten at home seated at a table for >20 minutes; they recommended the abundant use of olive oil, ≥2 daily servings of vegetables, ≥2 daily servings of fresh fruits, ≥3 weekly servings of legumes, ≥3 weekly servings of seafood, ≥1 weekly serving of nuts or seeds, poultry or rabbit rather than red meat, and to cook ≥2 times weekly with tomato, garlic, and onion.
- Dietitians recommended against dairy, cold meat, pate/duck, sugared/carbonated beverages, pastries and fried foods, and sweets.
- Wine was recommended as the main source of alcohol rather than beer or other spirits, with maximum 3 glasses of wine per day.
- For the olive oil group, patients were given one liter per week of extra-virgin olive oil
- For the nut group, patients received 2 kg walnuts, 1 kg almonds, 1kg hazelnuts every 3 months.
- Control diet group participants were given baseline dietary training only and received a pamphlet yearly until 2006 when they received the same frequency interventions as the Mediterranean groups:
- Dietitians recommend the avoidance of all types of fat, recommending low meats and low-fat dairy, cereals, potatoes, pasta, rice, fruits, and vegetables.
- Olive oil, nuts, and fatty meats (including fatty fish) were discouraged in the control group.
Comparisons are Mediterranean diet with olive oil vs. Mediterranean diet with nuts vs. low-fat control diet.
- Composite of MI, CVA, or CV death
- 8.1 vs. 8.0 vs. 11.2 events per 1000 person-years
- Mediterranean with olive oil vs. low fat: HR 0.69; 95% CI 0.53-0.91; P=0.008
- Mediterranean with nuts vs. low fat: HR 0.72; 95% CI 0.54-0.97; P=0.03
- Either Mediterranean vs. low fat: HR 0.70; 95% CI 0.55-0.89; P=0.003
- 4.1 vs. 3.1 vs. 5.9 events per 1000 person-years
- Mediterranean with olive oil vs. low fat: HR 0.67; 95% CI 0.46-0.98; P=0.04
- Mediterranean with nuts vs. low fat: HR 0.54; 95% CI 0.35-0.84; P=0.006
- Either Mediterranean vs. low fat: HR 0.61; 95% CI 0.44-0.86; P=0.005
- 3.1 vs. 3.0 vs. 3.9 events per 1000 person-years
- Mediterranean with olive oil vs. low fat: HR 0.80; 95% CI 0.51-1.26; P=0.34
- Mediterranean with nuts vs. low fat: HR 0.74; 95% CI 0.46-1.19; P=0.22
- Either Mediterranean vs. low fat: HR 0.77; 95% CI 0.51-1.15; P=0.20
- CV mortality
- 2.2 vs. 3.0 vs. 3.1 events per 1000 person-years
- Mediterranean with olive oil vs. low fat: HR 0.69; 95% CI 0.41-1.16; P=0.17
- Mediterranean with nuts vs. low fat: HR 1.01; 95% CI 0.61-1.66; P=0.98
- Either Mediterranean vs. low fat: HR 0.83; 95% CI 0.54-1.29; P=0.41
- All-cause mortality
- 10.0 vs. 11.2 vs. 11.7 events per 1000 person-years
- Mediterranean with olive oil vs. low fat: HR 0.82; 95% CI 0.64-1.07; P=0.15
- Mediterranean with nuts vs. low fat: HR 0.97; 95% CI 0.74-1.26; P=0.82
- Either Mediterranean vs. low fat: HR 0.89; 95% CI 0.71-1.12; P=0.32
- Self-reported adherence
- 8.7 vs. 8.7 vs. 8.4 points on a scale of 14 (higher indicates better adherence)
Among subgroups studied, there were no statistically significant differences in the rates of the primary outcome in either Mediterranean diet compared to the control diet. However, the P-value for interaction approached significance for BMI, suggesting that the diet may most benefit obese patients (P=0.05).
- The low fat control's protocol was changed during the trial and the lower intensity of the dietary intervention may have introduced bias
- Loss to follow up in the low fat group may have skewed results
- Participants lived in Mediterranean countries and were at high risk for CVD; thus, it's unclear if the results will be applicable to others
- A true low-fat diet was not achieved by the control group
- Unclear if olive oil or nuts would benefit other diets
- Adding olive oil or nuts has unclear effects on weight gain
- Unclear minimum dosing of olive oil and nuts
- The low risk reduction margins may have been accounted for in the baseline differences between the groups including sex, obsesity, use of diuretics, and use of oral hypoglycemics
- Unclear effects of the dietary interventions on cholesterol values
- The incidence of stroke accounts for the reduction in CV events
- Funded mostly through public sources. Various food makers donated olive oil and nuts, but sponsors were not involved in study design or implementation.
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