Preoperative Treatment of Locally Advanced Rectal Cancer
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Clinical Question
In patients with locally advanced rectal cancer (T2 node positive, T3 node negative, T3 node positive), is neoadjuvant chemotherapy inferior to neoadjuvant chemoradiotherapy with respect to disease-free survival?
Bottom Line
Neoadjuvant chemotherapy with FOLFOX was non-inferior to combined chemoradiotherapy with respect to 5-year disease-free survival.
Major Points
Guidelines
Design
Population
Inclusion Criteria
Exclusion Criteria
Baseline Characteristics
- Mean age:
Interventions
Outcomes
Comparisons are intensive therapy vs. standard therapy.