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* Goal BP ≤140/90 mmHg achieved by: | * Goal BP ≤140/90 mmHg achieved by: | ||
# Step 1: titrating assigned study drug | # Step 1: titrating assigned study drug | ||
** 12.5 to 25 mg/d for chlorthalidone | |||
** 2.5 to 10 mg/d for amlodipine | |||
** 10 to 40 mg/d for lisinopril | |||
# Step 2: adding open-label agents (atenolol, clonidine, or reserpine) or low doses of open-label step 1 drug classes | # Step 2: adding open-label agents (atenolol, clonidine, or reserpine) or low doses of open-label step 1 drug classes | ||
** 25 to 100 mg/d of atenolol | |||
** 0.05 to 0.2 mg/d of reserpine | |||
** 0.1 to 0.3 mg BID of clonidine | |||
# Step 3: adding 25 to 100 mg BID of hydralazine | # Step 3: adding 25 to 100 mg BID of hydralazine | ||