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* Randomly assigned to chlorthalidone, amlodipine, or lisinopril in a ratio of 1.7:1:1 | * Randomly assigned to chlorthalidone, amlodipine, or lisinopril in a ratio of 1.7:1:1 | ||
* Goal BP ≤140/90 mmHg achieved by: | * Goal BP ≤140/90 mmHg achieved by: | ||
** Step 1: titrating assigned study drug | |||
** 12.5 to 25 mg/d for chlorthalidone | *** 12.5 to 25 mg/d for chlorthalidone | ||
** 2.5 to 10 mg/d for amlodipine | *** 2.5 to 10 mg/d for amlodipine | ||
** 10 to 40 mg/d for lisinopril | *** 10 to 40 mg/d for lisinopril | ||
** Step 2: adding open-label agents (atenolol, clonidine, or reserpine) or low doses of open-label step 1 drug classes | |||
** 25 to 100 mg/d of atenolol | *** 25 to 100 mg/d of atenolol | ||
** 0.05 to 0.2 mg/d of reserpine | *** 0.05 to 0.2 mg/d of reserpine | ||
** 0.1 to 0.3 mg BID of clonidine | *** 0.1 to 0.3 mg BID of clonidine | ||
** Step 3: adding 25 to 100 mg BID of hydralazine | |||
==Measured outcomes and results== | ==Measured outcomes and results== | ||