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{"articlesQuery":{"topic":"all","articles":[{"timestamp":"2016-04-02T05:14:37Z","briefDesignDescription":"Central line complications by insertion site","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1500964","pageid":2479,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500964","trainingLevel":"Student","citation":"Parienti JJ, <i>et al</i>. \"Intravascular Complications of Central Venous Catheterization by Insertion Site\". <i>The New England Journal of Medicine</i>. 2015. 373(13):1220-1229.","subspecialties":"Critical Care;Infectious Disease","expansion":"","briefResultsDescription":"Subclavian lines yield fewer CRBSIs and DVTs compared to IJ/femoral lines","published":"2015-09-24","pageName":"3SITES","diseases":"Critical Illness;Catheter-Related Bloodstream Infection","abbreviation":"3SITES","title":"Intravascular Complications of Central Venous Catheterization by Insertion Site","pmid":"26398070"},{"timestamp":"2016-04-11T06:45:25Z","briefDesignDescription":"Simvastatin in stable CAD","fulltexturl":"http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)90566-5/abstract","pageid":1587,"pdfurl":"","trainingLevel":"Student","citation":"Pedersen TR, <i>et al</i>. \"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)\". <i>The Lancet</i>. 1994. 344(8934):1383-1389.","subspecialties":"Cardiology","expansion":"Scandinavian Simvastatin Survival Study","briefResultsDescription":"Simvastatin reduces all mortality in stable CAD","published":"1994-11-19","pageName":"4S","diseases":"Hyperlipidemia;Coronary Artery Disease","abbreviation":"4S","title":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)","pmid":"7968073"},{"timestamp":"2016-01-05T16:15:17Z","briefDesignDescription":"ISDN/hydralazine for black patients with HFrEF","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa042934","pageid":41,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa042934","trainingLevel":"Student","citation":"Taylor AL, <i>et al</i>. \"Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure\". <i>The New England Journal of Medicine</i>. 2004. 351(20):2049-2057.","subspecialties":"Cardiology","expansion":"African-American Heart Failure Trial","briefResultsDescription":"Improved survival among black patients with HF","published":"2004-11-11","pageName":"A-HeFT","diseases":"Heart Failure","abbreviation":"A-HeFT","title":"Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure","pmid":"15533851"},{"timestamp":"2016-12-04T22:11:25Z","briefDesignDescription":"AF ablation vs. amiodarone in HFrEF with LVEF ≤40%","fulltexturl":"http://circ.ahajournals.org/content/early/2016/03/30/CIRCULATIONAHA.115.019406","pageid":2829,"pdfurl":null,"trainingLevel":"Resident","citation":"Di Biase <i>et al</i>. \"Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device\". <i>Circulation</i>. 2016. 133(17):1637-1634.","subspecialties":"Cardiology","expansion":"Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device","briefResultsDescription":"AF ablation superior to amiodarone in HFrEF with LVEF ≤40%","published":"2016-04-26","pageName":"AATAC","diseases":"Atrial Fibrillation;Heart Failure","abbreviation":"AATAC","title":"Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device","pmid":"27029350"},{"timestamp":"2014-05-23T21:17:56Z","briefDesignDescription":"Benazepril/amlodipine vs. benazepril/HCTZ in HTN","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa0806182","pageid":1448,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa0806182","trainingLevel":"Resident","citation":"Jamerson K, <i>et al</i>. \"Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients\". <i>The New England Journal of Medicine</i>. 2008. 359(23):2417-2428.","subspecialties":"Cardiology","expansion":"Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension","briefResultsDescription":"Benazepril/amlodipine is associated with fewer CV events","published":"2008-12-04","pageName":"ACCOMPLISH","diseases":"Hypertension","abbreviation":"ACCOMPLISH","title":"Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients","pmid":"19052124"},{"timestamp":"2016-04-01T23:25:40Z","briefDesignDescription":"Intensive glycemic therapy in T2DM","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa0802743","pageid":105,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802743","trainingLevel":"Intern","citation":"Gerstein HC, <i>et al</i>. \"Effects of Intensive Glucose Lowering in Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2008. 358(24):2545-59.","subspecialties":"Endocrinology","expansion":"Action to Control Cardiovascular Risk in Diabetes","briefResultsDescription":"Increased mortality and no cardiovascular benefit with intensive glycemic control","published":"2008-06-12","pageName":"ACCORD","diseases":"Diabetes Mellitus","abbreviation":"ACCORD","title":"Effects of Intensive Glucose Lowering in Type 2 Diabetes","pmid":"18539917"},{"timestamp":"2015-11-15T16:57:13Z","briefDesignDescription":"Intensive BP control in T2DM","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1001286","pageid":1760,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001286","trainingLevel":"Student","citation":"ACCORD Study Group. \"Effects of intensive blood-pressure control in type 2 diabetes mellitus\". <i>The New England Journal of Medicine</i>. 2010. 362(17):1575-1585.","subspecialties":"Endocrinology","expansion":"ACCORD Study Group","briefResultsDescription":"Intensive BP control doesn't reduce CV events in T2DM","published":"2010-03-14","pageName":"ACCORD BP","diseases":"Diabetes Mellitus","abbreviation":"ACCORD BP","title":"Effects of intensive blood-pressure control in type 2 diabetes mellitus","pmid":"20228401"},{"timestamp":"2015-09-27T04:43:00Z","briefDesignDescription":"Acetylcysteine with IV contrast","fulltexturl":"http://circ.ahajournals.org/cgi/pmidlookup?view","pageid":2425,"pdfurl":"http://circ.ahajournals.org/content/124/11/1250.full.pdf","trainingLevel":"Intern","citation":"ACT Investigators. \"Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography\". <i>Circulation</i>. 2011. 124:1250-1259.","subspecialties":"Nephrology;Cardiology","expansion":"Acetylcysteine for Contrast-Induced Nephropathy Trial","briefResultsDescription":"Acetylcysteine doesn't prevent contrast-induced acute kidney injury","published":"2011-06-28","pageName":"ACT","diseases":"Acute Kidney Injury;Acute Coronary Syndrome","abbreviation":"ACT","title":"Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography","pmid":"21859972"},{"timestamp":"2015-02-02T18:51:43Z","briefDesignDescription":"ASA/clopidogrel vs. ASA in AF","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa0901301","pageid":360,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa0901301","trainingLevel":"Resident","citation":"Connolly SJ, <i>et al</i>. \"Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation\". <i>The New England Journal of 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Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.\". <i>The Lancet</i>. 2006. 367(9526):1903-12.","subspecialties":"Cardiology;Neurology","expansion":"Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events","briefResultsDescription":"Warfarin is superior to ASA/clopidogrel for stroke prevention in AF","published":"2006-06-10","pageName":"ACTIVE W","diseases":"Atrial Fibrillation;Stroke;Transient Ischemic Attack","abbreviation":"ACTIVE W","title":"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.","pmid":"16765759"},{"timestamp":"2017-01-19T20:24:11Z","briefDesignDescription":"Cisatracurium in 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\"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study\". <i>JAMA</i>. 2014. 311(11):1117-1124.","subspecialties":"Hematology;Emergency Medicine","expansion":"Age aDJUSTed D-Dimer to rule out PE","briefResultsDescription":"Age-adjusted D-dimer (age × 10 in patients >50) rules out PE","published":"2014-03-19","pageName":"ADJUST-PE","diseases":"Pulmonary Embolism;Venous Thromboembolism","abbreviation":"ADJUST-PE","title":"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study","pmid":"24643601"},{"timestamp":"2014-09-19T13:02:39Z","briefDesignDescription":"Intensive glycemic therapy in T2DM","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa0802987","pageid":248,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802987","trainingLevel":"Intern","citation":"Patel A, <i>et al</i>. \"Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2008. 358(24):2560-2572.","subspecialties":"Endocrinology","expansion":"Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation","briefResultsDescription":"Intensive therapy reduces microvascular complications","published":"2008-06-06","pageName":"ADVANCE","diseases":"Diabetes Mellitus","abbreviation":"ADVANCE","title":"Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes","pmid":"18539916"},{"timestamp":"2015-08-28T01:53:53Z","briefDesignDescription":"Rate vs. rhythm control in AF","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa021328","pageid":87,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa021328","trainingLevel":"Student","citation":"Wyse DG, <i>et al</i>. \"A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2002. 347(23):1825-1833.","subspecialties":"Cardiology","expansion":"Atrial Fibrillation Follow-up Investigation of Rhythm Management","briefResultsDescription":"No mortality difference, trend towards harm with rhythm control","published":"2002-11-05","pageName":"AFFIRM","diseases":"Atrial Fibrillation","abbreviation":"AFFIRM","title":"A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation","pmid":"12466506"},{"timestamp":"2016-01-10T06:27:00Z","briefDesignDescription":"Mammograms for 40-49 year old women","fulltexturl":"http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)69834-6","pageid":2307,"pdfurl":"","trainingLevel":"Student","citation":"Moss SM, <i>et al</i>. \"Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial\". <i>The Lancet</i>. 2006. 368(9552):2053-2060.","subspecialties":"Oncology;Preventive Medicine","expansion":"","briefResultsDescription":"Mammograms don't reduce breast cancer mortality in age 40-49 year old women","published":"2006-12-09","pageName":"Age Trial","diseases":"Breast Cancer","abbreviation":"Age Trial","title":"Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial","pmid":"17161727"},{"timestamp":"2017-01-28T19:50:05Z","briefDesignDescription":"Anakinra in colchicine-resistant pericarditis","fulltexturl":"http://jamanetwork.com/journals/jama/article-abstract/2579869","pageid":2865,"pdfurl":null,"trainingLevel":"Resident","citation":"Brucato A, <i>et al</i>. \"Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence\". <i>Journal of the American Medical Association</i>. 2016. 316(18):1906-1912.","subspecialties":"Cardiology","expansion":"","briefResultsDescription":"Anakinra superior to placebo in colchicine resistant, steroid-dependent pericarditis","published":"2016-11-08","pageName":"AIRTRIP","diseases":"Pericarditis","abbreviation":"AIRTRIP","title":"Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence","pmid":"27825009"},{"timestamp":"2017-03-06T14:47:01Z","briefDesignDescription":"Daily albumin in severe sepsis","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1305727","pageid":1781,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1305727","trainingLevel":"resident","citation":"Caironi P, <i>et al</i>. \"Albumin replacement in patients with severe sepsis or septic shock\". <i>The New England Journal of Medicine</i>. 2014. 370(15):1412-1421.","subspecialties":"Critical Care","expansion":"Albumin Italian Outcome Sepsis","briefResultsDescription":"Daily albumin with no mortality benefit at 28 days","published":"2014-03-18","pageName":"ALBIOS","diseases":"Sepsis","abbreviation":"ALBIOS","title":"Albumin replacement in patients with severe sepsis or septic shock","pmid":"24635772"},{"timestamp":"2015-08-24T04:58:54Z","briefDesignDescription":"Chlorthalidone in HTN","fulltexturl":"http://jama.ama-assn.org/content/288/23/2981.long","pageid":171,"pdfurl":"http://jama.ama-assn.org/content/288/23/2981.full.pdf","trainingLevel":"Student","citation":"Wright JT, <i>et al</i>. \"Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs. Diuretic\". <i>Journal of the American Medical Association</i>. 2002. 288(23):2981-2997.","subspecialties":"Nephrology;Cardiology","expansion":"The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial","briefResultsDescription":"Chlorthalidone performs similarly to lisinopril and amlodipine","published":"2002-12-18","pageName":"ALLHAT","diseases":"Hypertension","abbreviation":"ALLHAT","title":"Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs. Diuretic","pmid":"12479763"},{"timestamp":"2016-02-15T17:19:53Z","briefDesignDescription":"Apixaban vs. warfarin in VTE","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1302507","pageid":1609,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302507","trainingLevel":"Intern","citation":"Agnelli G, <i>et al</i>. \"Oral apixaban for the treatment of acute venous thromboembolism\". <i>The New England Journal of Medicine</i>. 2013. 369(9):799-808.","subspecialties":"Hematology;Pulmonology","expansion":"Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy","briefResultsDescription":"Apixaban noninferior to warfarin for VTE recurrence; less bleeding","published":"2013-07-01","pageName":"AMPLIFY","diseases":"Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis","abbreviation":"AMPLIFY","title":"Oral apixaban for the treatment of acute venous 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thromboembolism","pmid":"23216615"},{"timestamp":"2017-01-19T19:41:08Z","briefDesignDescription":"Corticosteroids in septic shock","fulltexturl":"http://jama.jamanetwork.com/article.aspx?articleid","pageid":939,"pdfurl":"http://jama.jamanetwork.com/data/Journals/JAMA/4844/JCE10061.pdf","trainingLevel":"Resident","citation":"Annane D, <i>et al</i>. \"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock\". <i>Journal of the American Medical Association</i>. 2002. 288(7):862-871.","subspecialties":"Critical Care","expansion":"","briefResultsDescription":"Corticosteroids reduce mortality in septic shock with adrenal insufficiency","published":"2002-08-21","pageName":"Annane Trial","diseases":"Sepsis;Shock","abbreviation":"","title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic 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<i>et al</i>. \"Apixaban versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2011. 365(11):981-982.","subspecialties":"Cardiology;Neurology","expansion":"Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation","briefResultsDescription":"Apixaban better for CVA prevention in AF","published":"2011-09-15","pageName":"ARISTOTLE","diseases":"Atrial Fibrillation;Stroke;Transient Ischemic Attack","abbreviation":"ARISTOTLE","title":"Apixaban versus warfarin in patients with atrial fibrillation","pmid":"21870978"},{"timestamp":"2015-12-29T16:22:06Z","briefDesignDescription":"Pirfenidone in IPF","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1402582","pageid":1825,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402582","trainingLevel":"Fellow","citation":"King TE, <i>et al</i>. \"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis\". <i>The New England Journal of 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{"articlesQuery":{"topic":"all","articles":[{"timestamp":"2016-04-02T05:14:37Z","briefDesignDescription":"Central line complications by insertion site","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1500964","pageid":2479,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500964","trainingLevel":"Student","citation":"Parienti JJ, <i>et al</i>. \"Intravascular Complications of Central Venous Catheterization by Insertion Site\". <i>The New England Journal of Medicine</i>. 2015. 373(13):1220-1229.","subspecialties":"Critical Care;Infectious Disease","expansion":"","briefResultsDescription":"Subclavian lines yield fewer CRBSIs and DVTs compared to IJ/femoral lines","published":"2015-09-24","pageName":"3SITES","diseases":"Critical Illness;Catheter-Related Bloodstream Infection","abbreviation":"3SITES","title":"Intravascular Complications of Central Venous Catheterization by Insertion 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UK Prospective Diabetes Study (UKPDS) Group.\". <i>The Lancet</i>. 1998. 352(9131):854-865.","subspecialties":"Endocrinology","expansion":"UK Prospective Diabetes Study 34","briefResultsDescription":"Metformin better than diet alone in T2DM","published":"1998-11-07","pageName":"UKPDS 34","diseases":"Diabetes Mellitus","abbreviation":"UKPDS 34","title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). 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<i>et al</i>. \"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure\". <i>New England Journal of Medicine</i>. 2001. 345(23):1667-75.","subspecialties":"Cardiology","expansion":"Valsartan Heart Failure Trial","briefResultsDescription":"No mortality benefit of valsartan in NYHA II-IV HF","published":"2001-12-06","pageName":"Val-HeFT","diseases":"Heart Failure","abbreviation":"Val-HeFT","title":"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure","pmid":"11759645"},{"timestamp":"2015-06-06T23:41:36Z","briefDesignDescription":"Sofosbuvir+ribavirin for HCV genotypes 2 or 3","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa1316145","pageid":2261,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa1316145","trainingLevel":"Student","citation":"Zeuzem S, <i>et al</i>. \"Sofosbuvir and ribavirin in HCV genotypes 2 and 3\". <i>The New England Journal of Medicine</i>. 2014. 370(21):1993-2001.","subspecialties":"Infectious Disease;Gastroenterology","expansion":"","briefResultsDescription":"Sofosbuvir+ribavirin effective without IFN","published":"2014-05-22","pageName":"VALENCE","diseases":"Hepatitis C","abbreviation":"VALENCE","title":"Sofosbuvir and ribavirin in HCV genotypes 2 and 3","pmid":"24795201"},{"timestamp":"2015-07-05T22:55:54Z","briefDesignDescription":"Valsartan vs. captopril in MI with LV dysfunction","fulltexturl":"http://www.nejm.org/doi/full/10.1056/NEJMoa032292","pageid":462,"pdfurl":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa032292","trainingLevel":"Resident","citation":"Pfeffer, MA <i>et al</i>. \"Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both\". <i>The New England Journal of Medicine</i>. 2003. 349(20):1893-1903.","subspecialties":"Cardiology","expansion":"Valsartan in Acute Myocardial Infarction Trial","briefResultsDescription":"Valsartan as effective as 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