APROCCHSS: Difference between revisions

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APROCCHSS (view source)

Revision as of 22:18, 3 March 2018

220 bytes added ,  3 March 2018
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→‎Outcomes
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==Outcomes==
==Outcomes==
<!-- Because we're comparing experimental and control groups, we usually start the outcomes section with a sentence like this one from ACCORD, just to be clear. The two single-quotes on each side make italics. -->
''Comparisons are Placebo vs. Hydrocortisone plus Fludrocortisone.''


''Comparisons are intensive therapy vs. standard therapy.''
===Primary Outcomes===
; All cause mortality at 90 days
: 49% vs. 43% (RR 0.88; 95% CI 0.78-0.99; P=0.03)
 
===Secondary Outcomes===
; All cause mortality at 28 days
: 39% vs. 34% (RR 0.87; 95% CI 0.75–1.01; P=0.06)


<!--The usual formatting leaves out the number of events:
; All cause mortality at ICU discharge
group1% vs. group2% (risk ratio, hazard ratio, or risk difference; 95% CI for comparison; P-value; NNT/NNH if needed) -->
: 41% vs. 35% (RR 0.86; 95% CI 0.75–0.99; P=0.04)


===Primary Outcomes===
; All cause mortality at hospital discharge
<!-- What were the primary outcomes of the study? Be careful with how stats are written. The name of the outcome starts with a semicolon (;) and the actual statistics for that outcome start with a colon (:), for example: -->
: 45% vs. 39% (RR 0.86; 95% CI 0.76–0.98; P=0.02)
 
; All cause mortality at 180 days
: 53% vs. 47% (RR 0.89; 95% CI 0.79–0.99; P=0.04)
 
; Decision to withdraw care/active treatment at 90 days
: 9% vs. 10% (RR 1.07; 95% CI 0.77–1.49; P=0.69)


;  
; Vasopressor-free days at 28 days
:  
: Mean 15±11 vs. 17±11 (P<0.001)
: Median(IRQ) 19(1–26) vs. 23(5–26)


===Secondary Outcomes===
; Ventilator-free days at 28 days
<!-- Ditto for secondary outcomes -->
: Mean 10±11 vs. 11±11 (P=0.07)
: Median(IRQ) 4(0–21) vs. 10(0–22)


;  
; Organ-failure-free days at 28 days
:  
: Mean 12±11 vs. 14±11 (P=0.003)
: Median(IRQ) 12(0–24) vs. 19(0–25)


===Subgroup Analysis===
===Subgroup Analysis===
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