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APROCCHSS: Difference between revisions
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→Interventions
| Line 77: | Line 77: | ||
2x2 factorial design, patients randomized: | 2x2 factorial design, patients randomized: | ||
* '''Hydrocortisone''' 50mg IV every 6 hours and fludrocortisone 50 mcg NG daily for 7 days without taper | * '''Hydrocortisone''' 50mg IV every 6 hours and fludrocortisone 50 mcg NG daily for 7 days without taper | ||
* '''Activated protein C''' 24 mcg/kg/h for 96 h<ref name=APC/> | * '''Activated protein C''' 24 mcg/kg/h for 96 h<ref name=APC/> ''This arm discontinued follow withdrawal of the product from the market'' | ||
* '''Placebo''' (mannitol 133.6 mg IV, microsrystalline cellulose 50 mg, and 0.95 Abnormal Saline) | * '''Placebo''' (mannitol 133.6 mg IV, microsrystalline cellulose 50 mg, and 0.95 Abnormal Saline) | ||