Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock: Difference between revisions

Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock (view source)

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 There were a number of limitations with this trial. The small sample size increases the risk of bias with the effect. The lack of a concurrent comparator group also must make us extremely cautious in interpreting these findings. For context, the use of historical controls has been identified as the second-lowest level of evidence quality in the Global Health Evidence Framework.<ref>[https://www.ncbi.nlm.nih.gov/books/NBK121300/table/appb.t21/ Shekelle PG, et al. Global Health Evidence Framework. ''Southern California Evidence-based Practice Center.'' 2013.]</ref> The generalizability is also limited due to the single centre design. By itself, this study is low-quality evidence and should not be used to drive management of patients with severe sepsis and septic shock.
-More recently, the 2020 [[VITAMINS]] study found no benefit for the protocol in the present study.
+More recently, the 2020 [[VITAMINS]] and the 2022 [[LOVIT]] trials found no benefit or harm for some or all of the interventions in the present study.
 ==Guidelines==