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- 1 Clinical Question
- 2 Bottom Line
- 3 Major Points
- 4 Guidelines
- 5 Design
- 6 Population
- 7 Interventions
- 8 Outcomes
- 9 Criticisms
- 10 Funding
- 11 Further Reading
Among comatose children aged 2 days to 18 years with return of spontaneous circulation (ROSC) after in-hospital cardiac arrest of any cause, does mild hypothermia (32-34ºC) lead to improved neurological outcomes at 12 months as compared to normothermia?
Among comatose children 2 days to 18 years who survived in-hospital cardiac arrest from any cause, mild therapeutic hypothermia (32-34ºC), as compared with targeted temperature control at normothermia (37ºC), does not improve favorable functional outcome at 12 months.
The Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children (THAPCA-IH) trial was designed to answer the question if mild hypothermia is neuroprotective in children with ROSC after in-hospital cardiac arrest. ... VABS-II score of at least 70 ...
As of July 2021, no guidelines have been published that reflect the results of this trial.
- Multicenter, double-blind, randomized, controlled trial
- Intervention (n=)
- Placebo (n=)
- Setting: 37 centres in Canada and the United States
- Enrollment: 295
- Mean follow-up: 12 months
- Analysis: Intention-to-treat
- Primary outcome: Survival with a good neurobehavioral outcome at 12 months (VABS-II score ≥70)
- older than 48 hours, less than 18 years
- cardiac arrest inside hospital walls
- received chest compressions for minimum 2 minutes
- remained dependant to mechanical ventilation following ROSC
- GCS motor response scale 5 or 6
- unable to undergo randomization within 6 hours of event
- Active/refractory bleeding
BLANK Group displayed
- Physiologic parameters:
- Anthropomorphics: Weight
- Site of infection
Comparisons are BLANK therapy vs. BLANK therapy.
- National Heart, Lung, and Blood Institute