User:Lzhou025

Lily Zhou (MD, MS, FRCPC), is a vascular neurologist at the Vancouver Stroke Program and an Assistant Professor at the University of British Columbia. She completed her neurology residency in Vancouver with the University of British Columbia and her fellowship at the Stanford Stroke Center.

Contributions

Neurology

Cerebrovascular Disease

• NAVIGATE ESUS: Rivaroxaban was not superior to aspirin in recurrent stroke prevention after an initial ESUS with increased bleeding risk
• POINT: Dual anti-platelets with ASA and plavix for 90 days leads to decreased stroke recurrence at the risk of increased bleeding
• MR CLEAN: IA intervention in addition to standard practice improves morbidity for proximal large artery strokes
• FLAME: Early fluoxetine improves motor outcomes post stroke
• EMBRACE: 30d EKG allowed for detection of more patients with AF among patients with cryptogenic strokes
• CRYSTAL-AF: Implantable cardiac monitors allowed for detection of more patients with AF among patients with cryptogenic strokes
• SAMMPRIS: IA intervention offered no benefit above best medical therapy for intracranial atherosclerosis
• WASID: ASA is as effect as Warfarin and safer for secondary stroke prevention in patients with intra-cranial atherosclerosis
• WARSS: No difference in ASA vs. Warfarin in recurrent ischemic in patients with non-cardioembolic stroke.
• PROGRESS: Perindopril and indapamide vs perindopril alone for secondary stroke prevention showing benefit of perindopril (with addition of indapamide at the discretion of the treating clinician) decreases risk of recurrent stroke
• HINTS study: 3-step beside assessments is better than MRI for differentiate peripheral vs. central vertigo
• SPS3-BP: Intensive SBP (<130 mm Hg) management does not reduce incident stroke when compared to higher-target BP control (target SBP 140-150 mmHg), however, there was a non-significant trend towards benefit P=0.08
• SPS3-Clopidogrel+ASA: Clopidogrel+ASA vs. ASA alone after lacunar stroke increases bleeding without lower risk of recurrent stroke
• ATACH II: In those with ICH, SBP of 110-139 mm Hg did not result in a lower rate of death or disability compared to target of 140 to 179 mm Hg.

Seizures and Epilepsy

• Veterans Affairs Status Epilepticus Cooperative Study Group: Diazepam + phenytoin vs. lorazepam vs. phenobarbital vs. phenytoin for status epilepticus termination
• RAMPART: IV lorazepam vs. IM midazolam in status epilepticus in pre-hospital setting

Multiple Sclerosis

• Optic Neuritis Treatment Trial: 3d IV methylprednisolone 250 mg Q6H with 2w of oral prednisone at 1 mg/kg/day more beneficial than oral prednisone at 1 mg/kg/day for 2 weeks alone for treatment of optic neuritis and decrease rate of recurrence

Hematology

• RE-VERSE AD: Idarucizumab is effective for reversal of dabigatran anticoagulation

Cardiology

• PROTECT AF: Percutaneous closure of the LAA with WATCHMAN device vs. warfarin therapy in AF

Radiology

• MRI vs. radiograph for LBP: Rapid MRI vs. radiography as initial modality for diagnosis of lower back pain

Landmark Papers Pending Summary

• CT before LP: Which characteristics suggest presence of space occupying lesions in adults with suspected meningitis