User:Michaelw2000

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About

Michael Ke Wang, BHSc, MD.

I am an Internal Medicine resident (PGY3) at McMaster University, and the associate editor at WikiJournalClub for nephrology.

My interests include studies pertaining to general internal medicine, cardiology, nephrology, and hypertension.

Contributions

Cardiology

HOPE-3 (2016): Untitrated rosuvastatin +- Candesartan/HCTZ improves cardiovascular outcomes in an ethnically diverse patients of intermediate cardiovascular risk.

OASIS-5 (2006): Fondaparinux improves mortality compared to enoxaparin in NSTE-ACS.

INTERHEART (2004): Three population attributable risk factors represent the majority of the risk for first myocardial infarction.

Diabetes

EMPA-REG OUTCOME (2015): SGLT-2 Inhibitors improve cardiovascular outcomes in type 2 diabetes.

Nephrology

CORAL (2014): Renal artery stenting does not reduce hypertension in atherosclerotic renal artery stenosis.

EVOLVE (2012): Cinacalcet does not prevent cardiovascular outcomes in hemodialysis patients.

ACT (2011): Acetylcysteine with contrast administration does not prevent nephropathy (CIN).

SHARP (2011): Simvastatin and ezetimibe reduces atherosclerotic disease in stage 3 and 4 CKD.

AURORA (2009): Simvastatin does not improve cardiovascular outcomes in hemodialysis patients.

ACE Inhibitors in Severe CKD (2006): Benazepril slows renal deterioration in stage 4 non-diabetic CKD.

Neurology

ECST (1998): Carotid endarterectomy reduces stroke or death in symptomatic carotid stenosis over 80%.

Hypertension

ASCOT-BPLA (2005): CCB + ACE Inhibitors (Amlodipine, perindopril) does not independently prevent cardiovascular disease as compared to B-blocker and thiazide (atenolol, bendroflumethiazide).

LIFE (2002): Losartan does not prevent cardiovascular outcomes compared to atenolol, though may reduce rates of stroke.

Infectious Disease/Respirology

Antibiotics for COPD Exacerbations (1987): Antibiotic use in selected outpatient cases of COPD exacerbations improves treatment success rates.

Potential Nephrology Articles

POSEIDON (2014): Hemodynamically guided fluid administration for prevention of CI-AKI.

Integer Score (2004): A simple score system for prognosticating risk of CI-AKI due to coronary angiography.

SYMPLICITY HTN-3 (2014): Renal denervation does not reduce blood pressure compared to sham control.

SuPAR (2015): Soluble urokinase receptor levels predict incidence and worsened progression of CKD in patients with normal eGFR.

PATHWAY-2 (2015): Spironolactone as an effective agent in resistant hypertension.