WikiJournalClub:Clinical question of the day

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Clinical question of the day
In patients with heart failure with preserved ejection fraction (HFpEF, LVEF ≥ 50%) and mild-moderate (NYHA II-III) symptoms, does the long-acting nitrate isosorbide mononitrate improve activity tolerance versus placebo?

The clinical question of the day is a micro feature of WJC that lets readers discover new journal article summaries. Each question is taken from the "Clinical Question" section of individual article summaries. These are updated daily by User:WJCBot and stored at Template:Pico of the day. The day's PICO question can be added to any page by adding {{pico of the day}}.