WikiJournalClub:List of landmark papers/Cardiology

Hypertension

• 1967 VA Cooperative Study htn control reduces morbidity [1]
• 2001 DASH DASH diet with differen sodium levels and bp results [2]
• 1992 TOHP I lifestyle interventions in prehypertension [3]
• 1997 TOHP II sodium interventions in prehypertension [4]
• 2008 HYVET BP treatment in elderly [5]

Stable CAD

PCI/CABG

• 2007 COURAGE PCI vs. OMT in stable CAD [6]
• 2009 BARI 2D PCI or CABG vs. OMT in T2DM and stable CAD [7]
• 2009 FAME FFR in PCI [8]
• 2009 SYNTAX PCI vs. CABG in LM/3VD [9]
• 2011 STICH CABG vs. OMT in LV dysfunction [10]
• 2012 FREEDOM CABG vs. PCI in DM [11]

RAAS inhibition

• 2000 HOPE Ramipril in high-risk patients [12]
• 2003 EUROPA Perindopril in stable CAD [13]
• 2004 PEACE Trandolapril in stable CAD [14]

Acute Coronary Syndrome

Antiplatelets

• 1988 Aspirin, heparin, or both in UA [15]
• 1988 ISIS-2: Aspirin and streptokinase in ACS [16]
• 2001 CURE Clopidogrel in UA/NSTEMI [17]
• 2005 CLARITY-TIMI 28 Clopidogrel in STEMI [18]
• 2007 TRITON-TIMI 38 Prasurgrel vs. clopidogrel in ACS [19]
• 2009 PLATO Ticagrelor vs. clopidogrel in ACS [20]
• 2010 CURRENT-OASIS 7 Dosing of clopidogrel and aspirin in ACS [21]

Anticoagulation

• 1988 Aspirin, heparin, or both in UA [22]
• 1996 Heparin in UA: meta-analysis [23]
• 2004 SYNERGY Enoxaparin vs. UFH in UA/NSTEMI [24]
• 2006 ACUITY Bivalirudin + GPIIb/IIIa vs. UFH + GPIIb/IIIa in ACS [25]
• 2006 ExTRACT-TIMI 25 Enoxaparin vs. UFH with fibrinolysis in STEMI [26]
• 2006 OASIS-5 Fondaparinux vs. enoxaparin in ACS [27]
• 2008 ISAR-REACT 3 Bivalirudin vs. UFH in stable angina/UA [28]
• 2012 ATLAS ACS-2, TIMI 51 Rivaroxaban in ACS [29]

β-blockers

• 2005 COMMIT Metoprolol in STEMI [30]

GPIIb/IIIa Inhibitors

• 2001 ADMIRAL Abciximab plus stenting in ACS [31]
• 2006 ACUITY Bivalirudin + GPIIb/IIIa vs. UFH + GPIIb/IIIa in ACS [32]
• 2008 ISAR-REACT 3 Bivalirudin vs. UFH in stable angina/UA [33]
• 2008 HORIZONS-AMI Bivalirudin vs. heparin+GPIIb/IIIa in STEMI [34]

PCI/CABG

• 1999 SHOCK Early PCI/CABG in ACS complicated by cardiogenic shock [35]
• 2003 DANAMI-2 Lytics vs. transfer for PCI in STEMI [36]
• 2006 BASKET-LATE DES vs. BMS [37]
• 2009 TIMACS Early (<24h) vs. delayed (>36h) intervention in ACS [38]
• 2010 BASKET-PROVE DES vs. BMS [39]
• Early invasive vs conservative approach 32% decreased rehosp for ACS, nonsignificant 16% decrease in MI, no change in mortality compared with conservative strategy.

Lytics

• 2006 ExTRACT-TIMI 25 Enoxaparin vs. UFH with fibrinolysis in STEMI [40]
• 2006 OASIS-6 Fondaparinux vs. UFH in STEMI [41]
• 2001 GUSTO-V Combined reteplase + abciximab vs. reteplase in STEMI [42]
• 2003 DANAMI-2 Lytics vs. transfer for PCI in STEMI [43]

RAAS inhibitors

• 1994 GISSI-3 Lisinipril in ACS [44]
• 1995 ISIS-4 Captopril in ACS [45]
• 2003 EPHESUS Eplerenone in post-MI LV dysfunction [46]
• 2003 VALIANT ARBS vs. ACE inhibitors post-MI and LV dysfunction [47]

Statins

• 2001 MIRACL Atorvastatin statins in post-MI [48]
• 2004 PROVE IT-TIMI 22 Intensive atorvastatin vs. moderate pravastatin post-MI [49]

ICD/CRT

• 2003 DINAMIT Prophylactic ICD in post-MI LV dysfunction [50]
• 2003 IRIS Prophylactic ICD early-post-MI [51]
• 2009 MADIT-CRT ICD-CRT in LV dysfunction and prolonged QRS [52]

Risk Assessment

• 2000 TIMI Risk stratification in UA/NSTEMI [53]
• 2012 ROMICAT-II: CT coronary angiography in acute chest pain [54]

Atrial Fibrillation

Epidemiology

• ATRIA Risk factors in AF

Management

• 2001 ACUTE TEE in AF [55] *363*
• 2002 AFFIRM Rate vs. rhythm control in chronic AF [56] *1993 cites*
• 2002 RACE Rate vs. rhythm control in chronic AF
• 2008 AF-CHF Rate vs. rhythm control in AF and HF [57] *421*
• 2010 RACE II Lenient vs. strict rate control in permanent AF [58]

Antiarrhythmics

• 2000 CTAF Amiodarone vs. sotalol or propafenone in AF [59]
• 2005 SAFE-T Amiodarone vs. sotalol in AF
• 2007 ADONIS Dronedarone for maintenance of SR in AF [60] *341*
• 2009 ATHENA Dronedarone in AF [61] *479*

Anticoagulation

• 1989 AFASAK Warfarin vs. aspirin in chronic AF [62] *1030*
• 1990 BAATAF Warfarin in chronic AF [63] *911 cites*
• 1991 SPAF I Warfarin vs. aspirin in chronic AF
• 1992 SPINAF Warfarin in chronic AF [64] *827*
• 1994 SPAF II Warfarin vs. aspirin in AF [65] *809*
• 1996 SPAF III Adjusted-dose warfarin vs. low-dose warfarin plus aspirin in AF [66] *858*
• 2000 HAEST LMWH vs. aspirin in AF [67]
• 2003 SPORTIF III Ximelagatran vs. warfarin in AF [68] *662*
• 2006 ACTIVE W Warfarin vs. aspirin plus clopidogrel in AF [69] *1996*
• 2007 BAFTA Warfarin vs. aspirin for AF in elderly [70] *508*
• 2009 ACTIVE Plavix and aspirin in AF [71] *427*
• 2009 RE-LY Dabigatran vs. coumadin in AF [72] *1577*
• 2011 ROCKET AF Rivaroxaban vs. warfarin in AF [73] *444*
• 2011 ARISTOTLE Apixaban vs. warfarin in AF [74] *388*
• 2011 AVERROES Apixaban vs. aspirin in AF [75] *321*

CHF

Hydralazine & nitrates

• 1986 V-HeFT ISDN/hydralazine in CHF [76]
• 1991 V-HeFTII Hydralazine & nitrates vs. Ace-inhibitors in CHF [77]
• 2004 A-HeFT ISDN/hydralazine in blacks with NYHA class III-IV CHF [78]

β-blockers

• 2000 MERIT-HF Metoprolol XL in CHF [79][80]
• 2002 COPERNICUS Carvedilol in severe CHF [81]
• 2003 COMET Carvedilol vs. metoprolol tartrate in CHF (Lancet 2003;362:7)

Ace-inhibitors

• 1987 CONSENSUS Enalapril in NYHAIV CHF [82]
• 1991 SOLVD Enalapril in CHF with EF <35% [83]
• 1992 SAVE Captopril in post-MI CHF with EF ≤ 40%[84]
• 1992 SOLVD-PEnalapril in aSx CHF with EF ≤ 35%[85]

ARBs

• 2001 Val-HeFT Valsartan in CHF [86]
• 2003 CHARM-Added Candesartan added to ACE inhibitors in CHF [87]
• 2003 CHARM-Preserved Candesartan added to ACE inhibitors in CHF [88]
• 2003 CHARM-Alternative Candesartan alone in CHF [89]
• 2008 I-PRESERVE Irbesartan in HFPEF [90]
• 2009 HEAL Higher doses of Losartan in CHF [91]

Aldosterone antagonists

• 1999 RALES Spironolactone in NYHA III/IV CHF & EF <= 35% [92]
• 2003 EPHESUS Eplerenone in post-MI patients with LV dysfunction EF≤40% [93]
• 2011 EMPHASIS-HF Eplerenone in NYHA II CHF with LVEF <30% [94]

Digoxin

• 1997 DIG Digoxin in CHF with LVEF ≤45%[95]

ICD

• 2002 MADIT-II ICD in post-MI CHF with LVEF ≤30 [96]
• 2004 DEFINITE ICD in severe, nonischemic dilated cardiomyopathy [97]
• 2004 DINAMIT Prophylactic ICD post-MI [98]
• 2005 SCD-HeFT Amiodarone vs. ICD in CHF [99]
• 2005 CARE-HF CRT in NYHA III-IV CHF [100]
• 2009 IRIS Prophylactic ICD post-MI [101]
• 2009 MADIT-CRT ICD-CRT in NYHA I-II CHF with EF < 30%, prolonged QRS [102]
• 2009 TIME-HF BNP- vs. Symptom-guided therapy in CHF [103]

Volume management

• 2007 UNLOAD Ultrafiltration in CHF (JACC 2007;49:675)
• 2010 DOSE Continuous vs. intermittent lasix
• 2012 CARRESS-HF Ultrafiltration in decompensated HF [104]

Nesiritide

• 2002 ASCEND-HF Nesiritide in CHF [105]

LVAD

• 2001 REMATCH LVAD in HF [106]
• 2006 LVAD in CHF [107]
• 2009 HEARTMATE II LVAD in advanced CHF [108]

Fish oil

• 2008 GISSI-HF FIsh oil in CHF [109]

Telemonitoring

• 2011 CHAMPION Wireless PA monitoring in CHF [110]

Cardiac Risk Assessment

• 2004 CARP Revascularization before elective vascular surgery [111]
• 2008 POISE Perioperative metoprolol succinate [112]
• 2009 DECREASE Preoperative fluvastatin [113]
• 2009 DECREASE-V Revascularization in high-risk patients before major vascular surgery [114]
• 2012 VISION: Post-op troponin for predicting mortality [115]

Endocarditis

• 2012 EASE Early surgery for endocarditis [116]