WikiJournalClub:List of landmark papers/Nephrology
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Hypertension
- ACE-inhibitors
- 1992 Captopril post-MI with LV dysfunction [NEJM 1992;327: 669–77]
- 2000 HOPE Ramipril NEJM 2000;342:145
- 2005 ASCOT-BPLA ACEI + CCB superior to BB + diuretic [1]
- 2008 ACCOMPLISH ACEI + CCB superior to ACE + thiazide [2]
- ARBs
- 2002 LIFE Losartan vs. atenolol Lancet 2002;359(9311):1004–1010
- 2006 TROPHY Candesartan in HTN NEJM 2006;354:1685
- 2008 ON-TARGET Telmisartan vs. ramipril in patients with vascular disease or high-risk diabetes [[3]]
- ß-blockers
- BHAT β-Blocker Heart Attack Trial (BHAT): propranolol in patients with recent MI
- ASCOT-BPLA ACEI + CCB superior to BB + diuretic Lancet 2005;366:895 http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67185-1/fulltext
- Calcium channel blockers
- ACCOMPLISH: ACEI + CCB superior to ACE + thiazide NEJM 2008;359:2417, full text
- 2005 ASCOT-BPLA ACEI + CCB superior to BB + diuretic [4]
- Diuretics
- 2002 ALLHAT: Chlortalidone vs. ACEI vs. CCB [5]
- 2008 ACCOMPLISH: ACEI + CCB superior to ACE + thiazide full text
- 2005 ASCOT-BPLA ACEI + CCB superior to BB + diuretic [6]
- Diet
- 1993 TOMHS Weight reduction, Na reduction, exercise
- 1997 DASH Diet rich in fruits & vegetables, low in saturated fat
- 2001 DASH-Sodium link
- 2003 PREMIER Weight loss, exercise, Na and ETOH reduction
- 2007 TOHP Dietary sodium restriction [7]
- Interventions
- 2008 JATOS: BP targets in elderly HTN [8]
- 2008 HYVET Treating stage II HTN in Pts > 80 [9]
- 2009 ASTRAL Revascularization vs. medical therapy for renal artery stenosis [10]
Hyponatremia
Acute Kidney Injury
- A Simple Risk Score for Prediction of Contrast-Induced Nephropathy After Percutaneous Coronary Intervention [[12]]
- N-AC may prevent contrast–induced nephropathy in patients treated with primary angioplasty [[13]]
- In patients with chronic renal insufficiency who are undergoing cardiac angiography, hydration with 0.45 percent saline provides better protection against acute decreases in renal function induced by radiocontrast agents than does hydration with 0.45 percent saline plus mannitol or furosemide [[14]]
- Hydration with sodium bicarbonate before contrast exposure for prophylaxis of contrast-induced renal failure. [[15]]
- Systematic Review: unclear if sodium bicarbonate more effective than saline [[16]]
- REMEDIAL The strategy of volume supplementation by sodium bicarbonate plus NAC seems to be superior to the combination of normal saline with NAC alone or with the addition of ascorbic acid in preventing CIN in patients at
medium to high risk. ([[17]
- iso-osmolar contrast [[18]]
- No benefit to dopamine [[19]]
- PICARD The use of diuretics in critically ill patients with acute renal failure was associated with an increased risk of death and nonrecovery of renal function. [[20]]
Chronic Kidney Disease
- ACEI in CKD 1993 Captopril protects against deterioration in renal function in insulin-dependent diabetic nephropathy and is significantly more effective than BP control alone. [[21]]
- ARB in CKD 2001 Irbesartan in type 2 diabetic nephropathy [[22]]
- Rates of all cause mortality and CV events increase with each stage of CKD [[23]]
- DETAIL 2004ARBs versus ACE-I in diabetic CKD [[24]]
- Hou et a 2006 Benazepril in advanced nondiabetic CKD [[25]]
- ACEI + ARB [[26]]
- ONTARGET In people at high vascular risk, telmisartan's effects on major renal outcomes are similar to ramipril. Although combination therapy reduces proteinuria to a greater extent than monotherapy, overall it worsens major renal outcomes.http://www.thelancet.com/journals/lancet/article/PIIS0140673608612362/abstract]]
- Sodium bicarbonate in CKD [[27]]
- 1998 Normal Hematocrit Study Target Hgb in anemia and CKD on dialysis [[28]]
- 2006 CHOIR Target Hgb in anemia and non-dialysis CKD [[29]]
- 2006 CREATE Target Hgb in anemia and non-dialysis CKD [[30]]
- 2009 TREAT Darbepoetin in non-dialysis CKD and T2DM [[31]]
- VA/NIH Acute Renal Failure Trial No mortality benefity for high intensity CVVH over standard therapy [[32]]
- No survival advantage of CVVH versus HD [[33]]
- 2002 AASK: BP control in hypertensive CKD [34]
- 2011 SHARP: LDL lowering in CKD [35]
- 2012 EVOLVE: Cinacalcet for CVD in ESRD [36]
Glomerulonephritis
- European Vasculitis Study Plasma Exchange versus High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis[[37]]
- Mycophenolate mofetil was more effective than intravenous cyclophosphamide in inducing remission of lupus nephritis and had a more favorable safety profile. [[38]]
- FIsh oil in IgA nephropathy [[39]]
- Steroids in IgA nephropathy [[40]]
Urinalysis
- Spot urine samples to estimate quantitative proteinuria [[41]]
Nephrolithiasis
- In men with recurrent calcium oxalate stones and hypercalciuria, restricted intake of animal protein and salt, combined with a normal calcium intake, provides greater protection than the traditional low-calcium diet.[[42]]