WikiJournalClub:List of landmark papers/Nephrology

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Hypertension

ACE-inhibitors
ARBs
ß-blockers
Calcium channel blockers
Diuretics
Diet
  • 1993 TOMHS Weight reduction, Na reduction, exercise
  • 1997 DASH Diet rich in fruits & vegetables, low in saturated fat
  • 2001 DASH-Sodium link
  • 2003 PREMIER Weight loss, exercise, Na and ETOH reduction
  • 2007 TOHP Dietary sodium restriction [7]
Interventions
  • 2008 JATOS: BP targets in elderly HTN [8]
  • 2008 HYVET Treating stage II HTN in Pts > 80 [9]
  • 2009 ASTRAL Revascularization vs. medical therapy for renal artery stenosis [10]

Hyponatremia

  • SALT Tolvaptan in symptomatic hyponatremia resistant to conventional therapy [[11]]

Acute Kidney Injury

  • A Simple Risk Score for Prediction of Contrast-Induced Nephropathy After Percutaneous Coronary Intervention [[12]]
  • N-AC may prevent contrast–induced nephropathy in patients treated with primary angioplasty [[13]]
  • In patients with chronic renal insufficiency who are undergoing cardiac angiography, hydration with 0.45 percent saline provides better protection against acute decreases in renal function induced by radiocontrast agents than does hydration with 0.45 percent saline plus mannitol or furosemide [[14]]
  • Hydration with sodium bicarbonate before contrast exposure for prophylaxis of contrast-induced renal failure. [[15]]
  • Systematic Review: unclear if sodium bicarbonate more effective than saline [[16]]
  • REMEDIAL The strategy of volume supplementation by sodium bicarbonate plus NAC seems to be superior to the combination of normal saline with NAC alone or with the addition of ascorbic acid in preventing CIN in patients at

medium to high risk. ([[17]

  • iso-osmolar contrast [[18]]
  • No benefit to dopamine [[19]]
  • PICARD The use of diuretics in critically ill patients with acute renal failure was associated with an increased risk of death and nonrecovery of renal function. [[20]]

Chronic Kidney Disease

Glomerulonephritis

  • European Vasculitis Study Plasma Exchange versus High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis[[37]]
  • Mycophenolate mofetil was more effective than intravenous cyclophosphamide in inducing remission of lupus nephritis and had a more favorable safety profile. [[38]]
  • FIsh oil in IgA nephropathy [[39]]
  • Steroids in IgA nephropathy [[40]]

Urinalysis

  • Spot urine samples to estimate quantitative proteinuria [[41]]

Nephrolithiasis

  • In men with recurrent calcium oxalate stones and hypercalciuria, restricted intake of animal protein and salt, combined with a normal calcium intake, provides greater protection than the traditional low-calcium diet.[[42]]

Transplant Nephrology