WikiJournalClub:Top Trials Series/Critical Care

The Top 25 Trials in Critical Care

Contributions by Chanu Rhee, MD, Fellow in Critical Care, Stanford Hospital & Clinics.

1. 2000 ARDSNet Low vs. traditional volumes in ARDS [1]
2. 2001 Rivers Trial Early goal-directed therapy in sepsis [2]
3. 1999 TRICC Hgb ≥7 vs. ≥10 in ICU patients [3]
4. 2009 NICE-SUGAR Intensive glycemic therapy in ICU [4]
5. 2001 Leuven Surgical Trial Intensive glycemic therapy in SICU [5]
6. 2002 HACA [6] [7]
7. 2000 Daily Sedation Holidays [8]
8. 2006 FACTT Fluid management in ARDS [9]
9. 2008 CORTICUS Hydrocortisone in septic shock [10]
10. 2003 PneumA 8 vs. 15 days for VAP [11]
11. 1991 Yang-Tobin Study Rapid Shallow Breathing Index [12]
12. 2010 Brower et al. High vs. Low PEEP in ARDS. [13]
13. 2010 SOAP-II Dopamine vs. norepinephrine in shock [14]
14. 2008 VASST Vasopressin vs. Norepinephrine in septic shock [15]
15. 1994 Risk factors for GI bleeding in critically ill patients [16]
16. 2007 Vancomycin vs. Metronidazole in C. difficile Diarrhea [17]
17. 2011 Fidaxomicin vs. Vancomycin in C. difficile Diarrhea [18]
18. 2008 ABC Spontaneous awakening trials [19]
19. 2011 Early vs. Late TPN in Critical Illness [20]
20. 2009 SEDCOM Dexmedetomidine vs. midazolam for sedation in ICU patients [21]
21. 2004 SAFE Albumin vs. saline in ICU patients [22]
22. 2006 Duration of hypotension before microbial therapy in septic shock
23. 2008 3CPO CPAP/BIPAP for Acute Cardiogenic Pulmonary Edema [23]
24. 2010 PRORATA Procalcitonin in ICU [24]
25. 2001 PROWESS Activated Protein C for Severe Sepsis [25]