- 1 Clinical Question
- 2 Bottom Line
- 3 Major Points
- 4 Guidelines
- 5 Design
- 6 Population
- 7 Interventions
- 8 Outcomes
- 9 Criticisms
- 10 Funding
- 11 Further Reading
In adults with newly diagnosed pulmonary tuberculosis, can the substitution of moxifloxacin for either isoniazid or ethambutol in a shortened four-month treatment regimen, compared to the standard six-month regimen, treat tuberculosis effectively?
Four-month tuberculosis regimens containing moxifloxacin are not as effective as the standard six-month regimen.
No guidelines have been published that reflect the results of this trial.
- Multicenter, double-blind, phase 3, randomized, placebo-controlled noninferiority trial
- N=1,931 underwent randomization
- Isoniazid group (n=655)
- Ethambutol group (n=636)
- Control group (n=640)
- Setting: Multicenter study in South Africa, India, Tanzania, Kenya, Thailand, Malaysia, Zambia, China and Mexico
- Study start date: January 2008. Study completion date: February 2014.
- Analysis: Modified intention-to-treat and per-protocol analysis
- Primary outcome: