RESTORE

Incomplete

Curley MA, et al. "Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial". JAMA. 2015. 313(4):379-389.
PubMed

Clinical Question

In pediatric ICU patients aged 2 weeks to 17 years, does a nurse-implemented, goal directed sedation protocol reduce mechanical ventilation days?

Bottom Line

The use of a sedation protocol compared with usual care in critically ill pediatric patients does not reduce the duration of mechanical ventilation.

Design

• Multicenter (31 pediatric ICUs in the US), cluster randomized trial
• N= 2449 pediatric patients
  • Intervention (17 PICUs): 1225 pediatric patients using protocol with targeted sedation
  • Control (14 PICUs): 1224 pediatric patients managed sedation per usual care
• Setting: 17 pediatric ICUs in the US
• Enrollment: 2009-2013
• Follow-up: 72 hrs after opioids were discontinued, 28 days or hospital discharge