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       "topic" : "all",
       "topic" : "all",
       "articles" : [
       "articles" : [
        {
            "timestamp" : "2017-12-03T22:32:58Z",
            "briefDesignDescription" : "Central line complications by insertion site",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500964",
            "pageid" : 2479,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500964",
            "trainingLevel" : "Student",
            "citation" : "Parienti JJ, <i>et al</i>. \"Intravascular Complications of Central Venous Catheterization by Insertion Site\". <i>The New England Journal of Medicine</i>. 2015. 373(13):1220-1229.",
            "subspecialties" : "Critical Care;Infectious Disease",
            "expansion" : "",
            "statusUsableDate" : "2015-11-01",
            "briefResultsDescription" : "Subclavian lines yield fewer CRBSIs and DVTs compared to IJ/femoral lines",
            "published" : "2015-09-24",
            "pageName" : "3SITES",
            "diseases" : "Critical Illness;Catheter-Related Bloodstream Infection",
            "abbreviation" : "3SITES",
            "title" : "Intravascular Complications of Central Venous Catheterization by Insertion Site",
            "pmid" : "26398070"
        },
         {
         {
             "timestamp" : "2017-12-14T19:22:25Z",
             "timestamp" : "2017-12-14T19:22:25Z",
Line 13: Line 32:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Scandinavian Simvastatin Survival Study",
             "expansion" : "Scandinavian Simvastatin Survival Study",
            "statusUsableDate" : "2013-08-01",
             "briefResultsDescription" : "Simvastatin reduces all mortality in stable CAD",
             "briefResultsDescription" : "Simvastatin reduces all mortality in stable CAD",
             "published" : "1994-11-19",
             "published" : "1994-11-19",
Line 31: Line 51:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "African-American Heart Failure Trial",
             "expansion" : "African-American Heart Failure Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Improved survival among black patients with HF",
             "briefResultsDescription" : "Improved survival among black patients with HF",
             "published" : "2004-11-11",
             "published" : "2004-11-11",
Line 38: Line 59:
             "title" : "Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure",
             "title" : "Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure",
             "pmid" : "15533851"
             "pmid" : "15533851"
        },
        {
            "timestamp" : "2017-12-03T22:33:01Z",
            "briefDesignDescription" : "AF ablation vs. amiodarone in HFrEF with LVEF ≤40%",
            "fulltexturl" : "http://circ.ahajournals.org/content/early/2016/03/30/CIRCULATIONAHA.115.019406",
            "pageid" : 2829,
            "pdfurl" : null,
            "trainingLevel" : "Resident",
            "citation" : "Di Biase <i>et al</i>. \"Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device\". <i>Circulation</i>. 2016. 133(17):1637-1634.",
            "subspecialties" : "Cardiology",
            "expansion" : "Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device",
            "statusUsableDate" : "2016-09-01",
            "briefResultsDescription" : "AF ablation superior to amiodarone in HFrEF with LVEF ≤40%",
            "published" : "2016-04-26",
            "pageName" : "AATAC",
            "diseases" : "Atrial Fibrillation;Heart Failure",
            "abbreviation" : "AATAC",
            "title" : "Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device",
            "pmid" : "27029350"
         },
         },
         {
         {
Line 49: Line 89:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension",
             "expansion" : "Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension",
            "statusUsableDate" : "2013-06-01",
             "briefResultsDescription" : "Benazepril/amlodipine is associated with fewer CV events",
             "briefResultsDescription" : "Benazepril/amlodipine is associated with fewer CV events",
             "published" : "2008-12-04",
             "published" : "2008-12-04",
Line 67: Line 108:
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Action to Control Cardiovascular Risk in Diabetes",
             "expansion" : "Action to Control Cardiovascular Risk in Diabetes",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Increased mortality and no cardiovascular benefit with intensive glycemic control",
             "briefResultsDescription" : "Increased mortality and no cardiovascular benefit with intensive glycemic control",
             "published" : "2008-06-12",
             "published" : "2008-06-12",
Line 85: Line 127:
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "ACCORD Study Group",
             "expansion" : "ACCORD Study Group",
            "statusUsableDate" : "2014-08-01",
             "briefResultsDescription" : "Intensive BP control doesn't reduce CV events in T2DM",
             "briefResultsDescription" : "Intensive BP control doesn't reduce CV events in T2DM",
             "published" : "2010-03-14",
             "published" : "2010-03-14",
Line 103: Line 146:
             "subspecialties" : "Cardiology;Endocrinology",
             "subspecialties" : "Cardiology;Endocrinology",
             "expansion" : "Action to Control Cardiovascular Risk in Diabetes-Lipid",
             "expansion" : "Action to Control Cardiovascular Risk in Diabetes-Lipid",
            "statusUsableDate" : "2018-01-17",
             "briefResultsDescription" : "Fenofibrates don't reduce CVD among adults with T2DM on statins",
             "briefResultsDescription" : "Fenofibrates don't reduce CVD among adults with T2DM on statins",
             "published" : "2010-04-29",
             "published" : "2010-04-29",
Line 121: Line 165:
             "subspecialties" : "Oncology;Surgery",
             "subspecialties" : "Oncology;Surgery",
             "expansion" : "The American College of Surgeons Oncology Group (ACOSOG) Z0011",
             "expansion" : "The American College of Surgeons Oncology Group (ACOSOG) Z0011",
            "statusUsableDate" : "2018-09-06",
             "briefResultsDescription" : "ALND no better than monitoring in SLNB-positive disease",
             "briefResultsDescription" : "ALND no better than monitoring in SLNB-positive disease",
             "published" : "2011-02-09",
             "published" : "2011-02-09",
Line 128: Line 173:
             "title" : "Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial",
             "title" : "Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial",
             "pmid" : "21304082"
             "pmid" : "21304082"
        },
        {
            "timestamp" : "2017-12-03T22:33:07Z",
            "briefDesignDescription" : "Acetylcysteine with IV contrast",
            "fulltexturl" : "http://circ.ahajournals.org/cgi/pmidlookup?view",
            "pageid" : 2425,
            "pdfurl" : "http://circ.ahajournals.org/content/124/11/1250.full.pdf",
            "trainingLevel" : "Intern",
            "citation" : "ACT Investigators. \"Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography\". <i>Circulation</i>. 2011. 124:1250-1259.",
            "subspecialties" : "Nephrology;Cardiology",
            "expansion" : "Acetylcysteine for Contrast-Induced Nephropathy Trial",
            "statusUsableDate" : "2015-08-01",
            "briefResultsDescription" : "Acetylcysteine doesn't prevent contrast-induced acute kidney injury",
            "published" : "2011-06-28",
            "pageName" : "ACT",
            "diseases" : "Acute Kidney Injury;Acute Coronary Syndrome",
            "abbreviation" : "ACT",
            "title" : "Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography",
            "pmid" : "21859972"
        },
        {
            "timestamp" : "2017-12-03T22:33:09Z",
            "briefDesignDescription" : "ASA/clopidogrel vs. ASA in AF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0901301",
            "pageid" : 360,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0901301",
            "trainingLevel" : "Resident",
            "citation" : "Connolly SJ, <i>et al</i>. \"Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2009. 360(20):2066-78.",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events",
            "statusUsableDate" : "2012-04-01",
            "briefResultsDescription" : "ASA/clopidogrel  ↓ composite of stroke, non-CNS embolism, MI, or CV death and ↑ bleeding",
            "published" : "2009-05-14",
            "pageName" : "ACTIVE A",
            "diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
            "abbreviation" : "ACTIVE A",
            "title" : "Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation",
            "pmid" : "19336502"
        },
        {
            "timestamp" : "2017-12-03T22:33:10Z",
            "briefDesignDescription" : "ASA/clopidogrel vs. warfarin in AF",
            "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)68845-4",
            "pageid" : 1438,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606688454.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Connolly SJ, <i>et al</i>. \"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.\". <i>The Lancet</i>. 2006. 367(9526):1903-12.",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events",
            "statusUsableDate" : "2013-05-01",
            "briefResultsDescription" : "Warfarin is superior to ASA/clopidogrel for stroke prevention in AF",
            "published" : "2006-06-10",
            "pageName" : "ACTIVE W",
            "diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
            "abbreviation" : "ACTIVE W",
            "title" : "Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.",
            "pmid" : "16765759"
        },
        {
            "timestamp" : "2017-12-03T22:33:12Z",
            "briefDesignDescription" : "Cisatracurium in ARDS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005372",
            "pageid" : 1119,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005372",
            "trainingLevel" : "resident",
            "citation" : "Papazian L, <i>et al</i>. \"Neuromuscular blockers in early acute respiratory distress syndrome\". <i>The New England Journal of Medicine</i>. 2010. 363(12):1107-1116.",
            "subspecialties" : "Critical Care",
            "expansion" : "ARDS et Curarisation Systematique",
            "statusUsableDate" : "2013-06-01",
            "briefResultsDescription" : "Cisatracurium improves 90-day survival and increases ventilator-free days",
            "published" : "2010-09-16",
            "pageName" : "ACURASYS",
            "diseases" : "Acute Respiratory Distress Syndrome",
            "abbreviation" : "ACURASYS",
            "title" : "Neuromuscular blockers in early acute respiratory distress syndrome",
            "pmid" : "20843245"
        },
        {
            "timestamp" : "2017-12-03T22:33:13Z",
            "briefDesignDescription" : "Age-adjusted D-dimer for PE",
            "fulltexturl" : "http://bit.ly/1QgJ5k1",
            "pageid" : 2367,
            "pdfurl" : "http://bit.ly/1HTY4kQ",
            "trainingLevel" : "Resident",
            "citation" : "Righini M, <i>et al</i>. \"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study\". <i>JAMA</i>. 2014. 311(11):1117-1124.",
            "subspecialties" : "Hematology;Emergency Medicine",
            "expansion" : "Age aDJUSTed D-Dimer to rule out PE",
            "statusUsableDate" : "2015-05-01",
            "briefResultsDescription" : "Age-adjusted D-dimer (age × 10 in patients >50) rules out PE",
            "published" : "2014-03-19",
            "pageName" : "ADJUST-PE",
            "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
            "abbreviation" : "ADJUST-PE",
            "title" : "Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study",
            "pmid" : "24643601"
         },
         },
         {
         {
Line 139: Line 279:
             "subspecialties" : "Critical Care",
             "subspecialties" : "Critical Care",
             "expansion" : "Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock",
             "expansion" : "Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock",
            "statusUsableDate" : "2018-02-08",
             "briefResultsDescription" : "Hydrocortisone provides no benefit in 90-day mortality",
             "briefResultsDescription" : "Hydrocortisone provides no benefit in 90-day mortality",
             "published" : "2018-01-19",
             "published" : "2018-01-19",
Line 157: Line 298:
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation",
             "expansion" : "Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Intensive therapy reduces microvascular complications",
             "briefResultsDescription" : "Intensive therapy reduces microvascular complications",
             "published" : "2008-06-06",
             "published" : "2008-06-06",
Line 175: Line 317:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Atrial Fibrillation Follow-up Investigation of Rhythm Management",
             "expansion" : "Atrial Fibrillation Follow-up Investigation of Rhythm Management",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "No mortality difference, trend towards harm with rhythm control",
             "briefResultsDescription" : "No mortality difference, trend towards harm with rhythm control",
             "published" : "2002-11-05",
             "published" : "2002-11-05",
Line 184: Line 327:
         },
         },
         {
         {
             "timestamp" : "2018-07-03T03:04:07Z",
            "timestamp" : "2017-12-03T22:33:43Z",
             "briefDesignDescription" : "Daily albumin in severe sepsis",
            "briefDesignDescription" : "Mammograms for 40-49 year old women",
            "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(06)69834-6",
            "pageid" : 2307,
            "pdfurl" : "",
            "trainingLevel" : "Student",
            "citation" : "Moss SM, <i>et al</i>. \"Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial\". <i>The Lancet</i>. 2006. 368(9552):2053-2060.",
            "subspecialties" : "Oncology;Preventive Medicine",
            "expansion" : "",
            "statusUsableDate" : "2015-01-01",
            "briefResultsDescription" : "Mammograms don't reduce breast cancer mortality in age 40-49 year old women",
            "published" : "2006-12-09",
            "pageName" : "Age Trial",
            "diseases" : "Breast Cancer",
            "abbreviation" : "Age Trial",
            "title" : "Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years' follow-up: A randomised controlled trial",
            "pmid" : "17161727"
        },
        {
            "timestamp" : "2017-12-03T22:33:14Z",
            "briefDesignDescription" : "Scaffold vs. stent in PCI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1614954",
            "pageid" : 2940,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1614954",
            "trainingLevel" : "Resident",
            "citation" : "Wykrzykowska JJ <i>et al</i>. \"Bioresorbable scaffolds versus metallic stents in routine PCI\". <i>The New England Journal of Medicine</i>. 2017. 376(24):2319-2328.",
            "subspecialties" : "Cardiology",
            "expansion" : "Amsterdam Investigator-Initiated Absorb Strategy All-Comers Trial",
            "statusUsableDate" : "2017-06-01",
            "briefResultsDescription" : "Scaffold inferior to stent in PCI",
            "published" : "2017-06-14",
            "pageName" : "AIDA",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "AIDA",
            "title" : "Bioresorbable scaffolds versus metallic stents in routine PCI",
            "pmid" : "28402237"
        },
        {
            "timestamp" : "2018-10-16T05:18:00Z",
            "briefDesignDescription" : "Anakinra in colchicine-resistant pericarditis",
            "fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2579869",
            "pageid" : 2865,
            "pdfurl" : null,
            "trainingLevel" : "Resident",
            "citation" : "Brucato A, <i>et al</i>. \"Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence\". <i>Journal of the American Medical Association</i>. 2016. 316(18):1906-1912.",
            "subspecialties" : "Cardiology",
            "expansion" : "AnakInRa for Treatment of Recurrent Idiopathic Pericarditis",
            "statusUsableDate" : "2016-12-01",
            "briefResultsDescription" : "Anakinra superior to placebo in colchicine resistant, steroid-dependent pericarditis",
            "published" : "2016-11-08",
            "pageName" : "AIRTRIP",
            "diseases" : "Pericarditis",
            "abbreviation" : "AIRTRIP",
            "title" : "Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence",
            "pmid" : "27825009"
        },
        {
            "timestamp" : "2017-12-03T22:33:17Z",
            "briefDesignDescription" : "Early vs. late RRT in severe AKI in ICU",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603017",
            "pageid" : 2937,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603017",
            "trainingLevel" : "Resident",
            "citation" : "Gaudry S, <i>et al</i>. \"Initiation strategies for renal-replacement therapy in the intensive care unit\". <i>The New England Journal of Medicine</i>. 2016. 375(2):122-133.",
            "subspecialties" : "Critical Care;Nephrology",
            "expansion" : "Artificial Kidney Initiation in Kidney Injury",
            "statusUsableDate" : "2017-08-01",
            "briefResultsDescription" : "No mortality difference between early or delayed RRT in ICU patients with AKI",
            "published" : "2016-07-14",
            "pageName" : "AKIKI",
            "diseases" : "Acute Kidney Injury",
            "abbreviation" : "AKIKI",
            "title" : "Initiation strategies for renal-replacement therapy in the intensive care unit",
            "pmid" : "27181456"
        },
        {
             "timestamp" : "2018-07-03T03:04:07Z",
             "briefDesignDescription" : "Daily albumin in severe sepsis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305727",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305727",
             "pageid" : 1781,
             "pageid" : 1781,
Line 193: Line 412:
             "subspecialties" : "Critical Care",
             "subspecialties" : "Critical Care",
             "expansion" : "Albumin Italian Outcome Sepsis",
             "expansion" : "Albumin Italian Outcome Sepsis",
            "statusUsableDate" : "2014-03-01",
             "briefResultsDescription" : "Daily albumin with no mortality benefit at 28 days",
             "briefResultsDescription" : "Daily albumin with no mortality benefit at 28 days",
             "published" : "2014-03-18",
             "published" : "2014-03-18",
Line 200: Line 420:
             "title" : "Albumin replacement in patients with severe sepsis or septic shock",
             "title" : "Albumin replacement in patients with severe sepsis or septic shock",
             "pmid" : "24635772"
             "pmid" : "24635772"
        },
        {
            "timestamp" : "2017-12-03T22:33:45Z",
            "briefDesignDescription" : "Albumin for SBP in cirrhosis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199908053410603",
            "pageid" : 2501,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199908053410603",
            "trainingLevel" : "Intern",
            "citation" : "Sort P, <i>et al</i>. \"Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis\". <i>The New England Journal of Medicine</i>. 1999. 341(6):403-409.",
            "subspecialties" : "Gastroenterology;Infectious Disease",
            "expansion" : "",
            "statusUsableDate" : "2017-09-01",
            "briefResultsDescription" : "Albumin reduces AKI and mortality in SBP in cirrhosis",
            "published" : "1999-08-05",
            "pageName" : "Albumin for SBP",
            "diseases" : "Spontaneous Bacterial Peritonitis;Cirrhosis",
            "abbreviation" : "",
            "title" : "Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis",
            "pmid" : "10432325"
         },
         },
         {
         {
Line 211: Line 450:
             "subspecialties" : "Nephrology;Cardiology",
             "subspecialties" : "Nephrology;Cardiology",
             "expansion" : "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial",
             "expansion" : "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Chlorthalidone performs similarly to lisinopril and amlodipine",
             "briefResultsDescription" : "Chlorthalidone performs similarly to lisinopril and amlodipine",
             "published" : "2002-12-18",
             "published" : "2002-12-18",
Line 229: Line 469:
             "subspecialties" : "Nephrology;Rheumatology",
             "subspecialties" : "Nephrology;Rheumatology",
             "expansion" : "Aspreva Lupus Management Study",
             "expansion" : "Aspreva Lupus Management Study",
            "statusUsableDate" : "2017-11-01",
             "briefResultsDescription" : "MMF similar to cyclophosphamide in lupus nephritis",
             "briefResultsDescription" : "MMF similar to cyclophosphamide in lupus nephritis",
             "published" : "2009-05-01",
             "published" : "2009-05-01",
Line 238: Line 479:
         },
         },
         {
         {
             "timestamp" : "2016-04-01T23:26:41Z",
             "timestamp" : "2017-12-03T22:33:22Z",
             "briefDesignDescription" : "Ceftriaxone vs. norfloxacin in cirrhotics with GI bleed",
             "briefDesignDescription" : "Apixaban vs. warfarin in VTE",
             "fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1302507",
             "pageid" : 82,
             "pageid" : 1609,
             "pdfurl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302507",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Fernández J, <i>et al</i>. \"Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage\". <i>Gastroenterology</i>. 2006. 131(4):1049-56.",
            "citation" : "Agnelli G, <i>et al</i>. \"Oral apixaban for the treatment of acute venous thromboembolism\". <i>The New England Journal of Medicine</i>. 2013. 369(9):799-808.",
             "subspecialties" : "Gastroenterology;Infectious Disease",
            "subspecialties" : "Hematology;Pulmonology",
             "expansion" : "",
            "expansion" : "Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "Apixaban noninferior to warfarin for VTE recurrence; less bleeding",
            "published" : "2013-07-01",
            "pageName" : "AMPLIFY",
            "diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
            "abbreviation" : "AMPLIFY",
            "title" : "Oral apixaban for the treatment of acute venous thromboembolism",
            "pmid" : "23808982"
        },
        {
            "timestamp" : "2017-12-03T22:33:24Z",
            "briefDesignDescription" : "Apixaban after VTE treatment",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1207541",
            "pageid" : 1245,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1207541",
            "trainingLevel" : "Resident",
            "citation" : "Agnelli G, <i>et al</i>. \"Apixaban for extended treatment of venous thromboembolism\". <i>The New England Journal of Medicine</i>. 2013. 368(8):699-708.",
            "subspecialties" : "Hematology",
            "expansion" : "Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy-Extended Treatment",
            "statusUsableDate" : "2013-05-01",
            "briefResultsDescription" : "Apixaban reduces recurrent VTE",
            "published" : "2013-02-21",
            "pageName" : "AMPLIFY-EXT",
            "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
            "abbreviation" : "AMPLIFY-EXT",
            "title" : "Apixaban for extended treatment of venous thromboembolism",
            "pmid" : "23216615"
        },
        {
            "timestamp" : "2018-03-04T15:37:10Z",
            "briefDesignDescription" : "Corticosteroids in septic shock",
            "fulltexturl" : "http://jama.jamanetwork.com/article.aspx?articleid",
            "pageid" : 939,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4844/JCE10061.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Annane D, <i>et al</i>. \"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock\". <i>Journal of the American Medical Association</i>. 2002. 288(7):862-871.",
            "subspecialties" : "Critical Care",
            "expansion" : "",
            "statusUsableDate" : "2013-02-01",
            "briefResultsDescription" : "Corticosteroids reduce mortality in septic shock with adrenal insufficiency",
            "published" : "2002-08-21",
            "pageName" : "Annane Trial",
            "diseases" : "Sepsis;Shock",
            "abbreviation" : "",
            "title" : "Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock",
            "pmid" : "12186604"
        },
        {
            "timestamp" : "2018-07-11T03:22:16Z",
            "briefDesignDescription" : "Andexanet for reversing Xa inhibitors",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1510991",
            "pageid" : 2502,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510991",
            "trainingLevel" : "Resident",
            "citation" : "Siegal DM, <i>et al</i>. \"Andexanet alfa for the reversal of factor Xa inhibitor activity\". <i>The New England Journal of Medicine</i>. 2015. 373(25):2413-2424.",
            "subspecialties" : "Hematology",
            "expansion" : "Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors",
            "statusUsableDate" : "2017-03-01",
            "briefResultsDescription" : "Andexanet reverses Xa inhibitors",
            "published" : "2015-12-17",
            "pageName" : "ANNEXA",
            "diseases" : "Hemorrhage",
            "abbreviation" : "ANNEXA",
            "title" : "Andexanet alfa for the reversal of factor Xa inhibitor activity",
            "pmid" : "26559317"
        },
        {
            "timestamp" : "2017-12-03T22:33:27Z",
            "briefDesignDescription" : "Pre-exposure prophylaxis in high-risk men",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506273",
            "pageid" : 2649,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506273",
            "trainingLevel" : "Student",
            "citation" : "Molina JM, <i>et al</i>. \"On-demand preexposure prophylaxis in men at high risk for HIV-1 infection\". <i>The New England Journal of Medicine</i>. 2015. 373(23):2237-2246.",
            "subspecialties" : "Infectious Disease",
            "expansion" : "",
            "statusUsableDate" : "2015-12-01",
            "briefResultsDescription" : "Pre-exposure prophylaxis reduces HIV transmission in high-risk men",
            "published" : "2015-12-03",
            "pageName" : "ANRS IPERGAY",
            "diseases" : "HIV",
            "abbreviation" : "ANRS IPERGAY",
            "title" : "On-demand preexposure prophylaxis in men at high risk for HIV-1 infection",
            "pmid" : "26624850"
        },
        {
            "timestamp" : "2016-04-01T23:26:41Z",
            "briefDesignDescription" : "Ceftriaxone vs. norfloxacin in cirrhotics with GI bleed",
            "fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/fulltext",
            "pageid" : 82,
            "pdfurl" : "http://www.gastrojournal.org/article/S0016-5085(06)01535-6/pdf",
            "trainingLevel" : "Intern",
             "citation" : "Fernández J, <i>et al</i>. \"Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage\". <i>Gastroenterology</i>. 2006. 131(4):1049-56.",
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "expansion" : "",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Ceftriaxone reduces the incidence of bacterial infection",
             "briefResultsDescription" : "Ceftriaxone reduces the incidence of bacterial infection",
             "published" : "2006-10-01",
             "published" : "2006-10-01",
Line 265: Line 602:
             "subspecialties" : "Surgery;Infectious Disease",
             "subspecialties" : "Surgery;Infectious Disease",
             "expansion" : "Appendicitis Acuta",
             "expansion" : "Appendicitis Acuta",
            "statusUsableDate" : "2018-07-26",
             "briefResultsDescription" : "Antibiotics not non-inferior to surgeyr",
             "briefResultsDescription" : "Antibiotics not non-inferior to surgeyr",
             "published" : "2015-06-16",
             "published" : "2015-06-16",
Line 283: Line 621:
             "subspecialties" : "Critical Care",
             "subspecialties" : "Critical Care",
             "expansion" : "Acute Respiratory Distress Syndrome Network",
             "expansion" : "Acute Respiratory Distress Syndrome Network",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Mortality benefit and more ventilator-free days with lung-protective strategy",
             "briefResultsDescription" : "Mortality benefit and more ventilator-free days with lung-protective strategy",
             "published" : "2000-05-04",
             "published" : "2000-05-04",
Line 290: Line 629:
             "title" : "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome",
             "title" : "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome",
             "pmid" : "10793162"
             "pmid" : "10793162"
        },
        {
            "timestamp" : "2017-12-03T22:33:28Z",
            "briefDesignDescription" : "EGDT vs. usual care in sepsis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1404380",
            "pageid" : 2216,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1404380",
            "trainingLevel" : "Intern",
            "citation" : "ARISE and ANZICS writers. \"Goal-directed resuscitation for patients with early septic shock\". <i>The New England Journal of Medicine</i>. 2014. 371(16):1496-1506.",
            "subspecialties" : "Critical Care",
            "expansion" : "Australasian Resuscitation in Sepsis Evaluation",
            "statusUsableDate" : "2014-11-01",
            "briefResultsDescription" : "EGDT doesn't reduce mortality in sepsis",
            "published" : "2014-10-16",
            "pageName" : "ARISE",
            "diseases" : "Sepsis",
            "abbreviation" : "ARISE",
            "title" : "Goal-directed resuscitation for patients with early septic shock",
            "pmid" : "25272316"
         },
         },
         {
         {
Line 301: Line 659:
             "subspecialties" : "Cardiology;Neurology",
             "subspecialties" : "Cardiology;Neurology",
             "expansion" : "Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation",
             "expansion" : "Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation",
            "statusUsableDate" : "2013-06-01",
             "briefResultsDescription" : "Apixaban better for CVA prevention in AF",
             "briefResultsDescription" : "Apixaban better for CVA prevention in AF",
             "published" : "2011-09-15",
             "published" : "2011-09-15",
Line 319: Line 678:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "A Study of Cardiovascular Events in Diabetes",
             "expansion" : "A Study of Cardiovascular Events in Diabetes",
            "statusUsableDate" : "2018-09-06",
             "briefResultsDescription" : "Aspirin reduces cardiovascular events but increases bleeding vs. placebo",
             "briefResultsDescription" : "Aspirin reduces cardiovascular events but increases bleeding vs. placebo",
             "published" : "2018-08-26",
             "published" : "2018-08-26",
Line 337: Line 697:
             "subspecialties" : "Pulmonology",
             "subspecialties" : "Pulmonology",
             "expansion" : "Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis",
             "expansion" : "Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis",
            "statusUsableDate" : "2014-07-01",
             "briefResultsDescription" : "Pirfenidone reduces progression of IPF",
             "briefResultsDescription" : "Pirfenidone reduces progression of IPF",
             "published" : "2014-05-29",
             "published" : "2014-05-29",
Line 344: Line 705:
             "title" : "A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis",
             "title" : "A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis",
             "pmid" : "24836312"
             "pmid" : "24836312"
        },
        {
            "timestamp" : "2017-12-03T22:33:32Z",
            "briefDesignDescription" : "Aspirin after VTE treatment",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210384",
            "pageid" : 1241,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210384",
            "trainingLevel" : "Intern",
            "citation" : "Brighton TA, <i>et al</i>. \"Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2012. 367(21):1979-1987.",
            "subspecialties" : "Hematology",
            "expansion" : "Aspirin to Prevent Recurrent Venous Thromboembolism",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "ASA probably reduces recurrent VTE",
            "published" : "2012-11-04",
            "pageName" : "ASPIRE",
            "diseases" : "Venous Thromboembolism",
            "abbreviation" : "ASPIRE",
            "title" : "Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism",
            "pmid" : "23121403"
         },
         },
         {
         {
Line 355: Line 735:
             "subspecialties" : "Nephrology",
             "subspecialties" : "Nephrology",
             "expansion" : "Angioplasty and Stenting for Renal Artery Lesions",
             "expansion" : "Angioplasty and Stenting for Renal Artery Lesions",
            "statusUsableDate" : "2013-09-01",
             "briefResultsDescription" : "Revascularization no better than medical therapy alone in RAS",
             "briefResultsDescription" : "Revascularization no better than medical therapy alone in RAS",
             "published" : "2009-11-12",
             "published" : "2009-11-12",
Line 362: Line 743:
             "title" : "Revascularization versus medical therapy for renal-artery stenosis",
             "title" : "Revascularization versus medical therapy for renal-artery stenosis",
             "pmid" : "19907042"
             "pmid" : "19907042"
        },
        {
            "timestamp" : "2017-12-03T22:33:35Z",
            "briefDesignDescription" : "Angiotensin II vs. placebo in vasodilatory shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1704154",
            "pageid" : 2950,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1704154",
            "trainingLevel" : "Resident",
            "citation" : "Khanna A <i>et al</i>. \"Angiotensin II for the Treatment of Vasodilatory Shock\". <i>New Engl J Med</i>. 2017. 377:419-30.",
            "subspecialties" : "Critical Care",
            "expansion" : "Angiotensin II for the Treatment of High-Output Shock",
            "statusUsableDate" : "2017-08-01",
            "briefResultsDescription" : "Angiotensin II superior to placebo in vasodilatory shock",
            "published" : "2017-08-03",
            "pageName" : "ATHOS-3",
            "diseases" : "Shock",
            "abbreviation" : "ATHOS-3",
            "title" : "Angiotensin II for the Treatment of Vasodilatory Shock",
            "pmid" : "28528561"
        },
        {
            "timestamp" : "2017-12-03T22:33:36Z",
            "briefDesignDescription" : "10y vs. 5y tamoxifen in breast cancer",
            "fulltexturl" : "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596060/",
            "pageid" : 1581,
            "pdfurl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61963-1/fulltext",
            "trainingLevel" : "Fellow",
            "citation" : "Davies C, <i>et al</i>. \"Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial\". <i>The Lancet</i>. 2013. 381(9869):805-16.",
            "subspecialties" : "Oncology",
            "expansion" : "Adjuvant Tamoxifen: Longer Against Shorter",
            "statusUsableDate" : "2013-10-01",
            "briefResultsDescription" : "10 years of tamoxifen reduces recurrence and mortality",
            "published" : "2013-03-09",
            "pageName" : "ATLAS",
            "diseases" : "Breast Cancer",
            "abbreviation" : "ATLAS",
            "title" : "Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial",
            "pmid" : "23219286"
        },
        {
            "timestamp" : "2017-12-03T22:33:37Z",
            "briefDesignDescription" : "Rivaroxaban after ACS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112277",
            "pageid" : 174,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112277",
            "trainingLevel" : "Resident",
            "citation" : "Mega JL, <i>et al</i>. \"Rivaroxaban in Patients with Recent Acute Coronary Syndrome\". <i>The New England Journal of Medicine</i>. 2012. 366(1):9-19.",
            "subspecialties" : "Cardiology",
            "expansion" : "Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51",
            "statusUsableDate" : "2013-03-01",
            "briefResultsDescription" : "Rivaroxaban reduces cardiovascular death, MI, and stroke, but increases nonfatal bleeding",
            "published" : "2012-01-05",
            "pageName" : "ATLAS ACS-2, TIMI 51",
            "diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
            "abbreviation" : "ATLAS ACS 2-TIMI 51",
            "title" : "Rivaroxaban in Patients with Recent Acute Coronary Syndrome",
            "pmid" : "22077192"
        },
        {
            "timestamp" : "2017-12-03T22:33:39Z",
            "briefDesignDescription" : "RRT intensity in ATN",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0802639",
            "pageid" : 2339,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0802639",
            "trainingLevel" : "Resident",
            "citation" : "Palevsky PM, <i>et al</i>. \"Intensity of renal support in critically ill patients with acute kidney injury\". <i>The New England Journal of Medicine</i>. 2008. 359(1):7-20.",
            "subspecialties" : "Nephrology;Critical Care",
            "expansion" : "Acute Renal Failure Trial Network Study",
            "statusUsableDate" : "2015-03-01",
            "briefResultsDescription" : "Intensive RRT yields similar mortality as conventional RRT in critically ill patients with ATN",
            "published" : "2008-07-03",
            "pageName" : "ATN",
            "diseases" : "Acute Kidney Injury;Critical Illness",
            "abbreviation" : "ATN",
            "title" : "Intensity of renal support in critically ill patients with acute kidney injury",
            "pmid" : "18492867"
         },
         },
         {
         {
Line 373: Line 830:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "The Transthyretin Amyloidosis Cardiomyopathy Clinical Trial",
             "expansion" : "The Transthyretin Amyloidosis Cardiomyopathy Clinical Trial",
            "statusUsableDate" : "2018-09-05",
             "briefResultsDescription" : "Tafamidis superior to placebo in amyloid cardiomyopathy",
             "briefResultsDescription" : "Tafamidis superior to placebo in amyloid cardiomyopathy",
             "published" : "2018-08-27",
             "published" : "2018-08-27",
Line 391: Line 849:
             "subspecialties" : "Hematology",
             "subspecialties" : "Hematology",
             "expansion" : "Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis",
             "expansion" : "Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis",
            "statusUsableDate" : "2018-07-19",
             "briefResultsDescription" : "No difference with intervention vs. anticoagulation",
             "briefResultsDescription" : "No difference with intervention vs. anticoagulation",
             "published" : "2017-12-07",
             "published" : "2017-12-07",
Line 400: Line 859:
         },
         },
         {
         {
             "timestamp" : "2014-12-01T14:21:22Z",
            "timestamp" : "2017-12-03T22:33:40Z",
             "briefDesignDescription" : "DMARD ± prednisone or infliximab in RA",
            "briefDesignDescription" : "Apixaban vs. ASA in AF",
             "fulltexturl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/abstract",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007432",
             "pageid" : 77,
            "pageid" : 1718,
             "pdfurl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/pdf",
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007432",
             "trainingLevel" : "Resident",
            "trainingLevel" : "Intern",
             "citation" : "Goekoop-Ruiterman YP, <i>et al</i>. \"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis\". <i>Arthritis & Rheumatism</i>. 2005. 52(11):3381-3390.",
            "citation" : "Connolly SJ, <i>et al</i>. \"Apixaban in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2011. 364(9):806-817.",
             "subspecialties" : "Rheumatology",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment",
            "statusUsableDate" : "2013-11-01",
            "briefResultsDescription" : "Apixaban better than ASA without increased bleeding in AF",
            "published" : "2011-03-03",
            "pageName" : "AVERROES",
            "diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
            "abbreviation" : "AVERROES",
            "title" : "Apixaban in patients with atrial fibrillation",
            "pmid" : "21309657"
        },
        {
            "timestamp" : "2017-12-03T22:33:41Z",
            "briefDesignDescription" : "Supplemental oxygen in STEMI",
            "fulltexturl" : "http://circ.ahajournals.org/content/131/24/2143",
            "pageid" : 2930,
            "pdfurl" : "http://circ.ahajournals.org/content/131/24/2143.full.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Stub D, <i>et al</i>. \"Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction\". <i>Circulation</i>. 2015. 131(24):2143-2150.",
            "subspecialties" : "Cardiology",
            "expansion" : "Comparing Oxygen with normal air in patients with ST-Segment Elevation Myocardial Infarction who are not hypoxic.",
            "statusUsableDate" : "2017-09-01",
            "briefResultsDescription" : "No benefit from in non-hypoxemic patients with STEMI",
            "published" : "2015-05-22",
            "pageName" : "AVOID",
            "diseases" : "Myocardial Infarction",
            "abbreviation" : "AVOID",
            "title" : "Air Versus Oxygen in ST-Segment Elevation Myocardial Infarction",
            "pmid" : "26002889"
        },
        {
            "timestamp" : "2017-12-03T22:33:42Z",
            "briefDesignDescription" : "Zidovudine in HIV/AIDS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198707233170401",
            "pageid" : 1775,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198707233170401",
            "trainingLevel" : "Student",
            "citation" : "Fischl MA <i>et al</i>. \"The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex\". <i>The New England Journal of Medicine</i>. 1987. 317(4):185-191.",
            "subspecialties" : "Infectious Disease",
            "expansion" : "",
            "statusUsableDate" : "2014-01-01",
            "briefResultsDescription" : "Zidovudine reduces mortality in HIV/AIDS",
            "published" : "1987-07-23",
            "pageName" : "AZT Trial",
            "diseases" : "HIV",
            "abbreviation" : "",
            "title" : "The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex",
            "pmid" : "3299089"
        },
        {
            "timestamp" : "2017-12-03T22:33:47Z",
            "briefDesignDescription" : "CABG/PCI vs. OMT in diabetes with CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805796",
            "pageid" : 1471,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805796",
            "trainingLevel" : "Resident",
            "citation" : "Frye RL, <i>et al</i>. \"A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease\". <i>The New England Journal of Medicine</i>. 2009. 360(24):2503-2515.",
            "subspecialties" : "Cardiology;Endocrinology",
            "expansion" : "Bypass Angioplasty Revascularization Investigation 2 Diabetes",
            "statusUsableDate" : "2013-06-01",
            "briefResultsDescription" : "CABG is superior to OMT in diabetics with CAD",
            "published" : "2009-06-11",
            "pageName" : "BARI 2D",
            "diseases" : "Coronary Artery Disease;Diabetes Mellitus",
            "abbreviation" : "BARI 2D",
            "title" : "A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease",
            "pmid" : "19502645"
        },
        {
            "timestamp" : "2017-12-03T22:33:48Z",
            "briefDesignDescription" : "Symptom-based asthma therapy",
            "fulltexturl" : "http://bit.ly/1FNk0v0",
            "pageid" : 1864,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/24854/joc120069_987_997.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Calhoun WJ, <i>et al</i>. \"Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial\". <i>Journal of the American Medical Association</i>. 2012. 308(10):987-997.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Best Adjustment Strategy for Asthma in the Long Term",
            "statusUsableDate" : "2015-03-01",
            "briefResultsDescription" : "Symptom-, biomarker-, and physician-based treatments are similar",
            "published" : "2012-09-12",
            "pageName" : "BASALT",
            "diseases" : "Asthma",
            "abbreviation" : "BASALT",
            "title" : "Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial",
            "pmid" : "22968888"
        },
        {
            "timestamp" : "2017-12-03T22:33:54Z",
            "briefDesignDescription" : "Benazepril in non-diabetic CKD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa053107",
            "pageid" : 2674,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa053107",
            "trainingLevel" : "Resident",
            "citation" : "Hou FF, <i>et al</i>. \"Effect and Safety of Benazepril for Advanced Chronic Renal Insufficiency\". <i>The New England Journal of Medicine</i>. 2006. 354(2):131-140.",
            "subspecialties" : "Nephrology",
            "expansion" : "",
            "statusUsableDate" : "2016-02-01",
            "briefResultsDescription" : "Benazepril improves renal outcomes in non-diabetic CKD",
            "published" : "2006-01-12",
            "pageName" : "Benazepril in Severe CKD",
            "diseases" : "Chronic Kidney Disease",
            "abbreviation" : "",
            "title" : "Effect and Safety of Benazepril for Advanced Chronic Renal Insufficiency",
            "pmid" : "16407508"
        },
        {
             "timestamp" : "2014-12-01T14:21:22Z",
             "briefDesignDescription" : "DMARD ± prednisone or infliximab in RA",
             "fulltexturl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/abstract",
             "pageid" : 77,
             "pdfurl" : "http://onlinelibrary.wiley.com/doi/10.1002/art.21405/pdf",
             "trainingLevel" : "Resident",
             "citation" : "Goekoop-Ruiterman YP, <i>et al</i>. \"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis\". <i>Arthritis & Rheumatism</i>. 2005. 52(11):3381-3390.",
             "subspecialties" : "Rheumatology",
             "expansion" : "Behandel-Strategeieën (\"treatment strategies\" in Dutch)",
             "expansion" : "Behandel-Strategeieën (\"treatment strategies\" in Dutch)",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Combination therapy produces early functional improvement than DMARD alone",
             "briefResultsDescription" : "Combination therapy produces early functional improvement than DMARD alone",
             "published" : "2005-11-01",
             "published" : "2005-11-01",
Line 418: Line 992:
         },
         },
         {
         {
             "timestamp" : "2018-01-17T21:45:20Z",
            "timestamp" : "2017-12-03T22:33:49Z",
             "briefDesignDescription" : "LMWH bridging for surgery in AF",
            "briefDesignDescription" : "PCI vs. CABG for multivessel disease",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501035",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1415447",
            "pageid" : 2916,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1415447",
            "trainingLevel" : "Resident",
            "citation" : "Reardon MJ, <i>et al</i>. \"Trial of everolimus-eluting stents or bypass surgery for coronary disease\". <i>The New England Journal of Medicine</i>. 2015. 372(13):1204-12.",
            "subspecialties" : "Cardiology",
            "expansion" : "The Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation",
            "statusUsableDate" : "2017-05-01",
            "briefResultsDescription" : "PCI inferior to CABG for multivessel disease",
            "published" : "2015-03-26",
            "pageName" : "BEST",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "BEST",
            "title" : "Trial of everolimus-eluting stents or bypass surgery for coronary disease",
            "pmid" : "25774645"
        },
        {
            "timestamp" : "2017-12-03T22:33:51Z",
            "briefDesignDescription" : "RV pacing vs. BiV pacing in HF with AV block",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210356",
            "pageid" : 2422,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210356",
            "trainingLevel" : "resident",
            "citation" : "Curtis A.B., <i>et al</i>. \"Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block\". <i>The New England Journal of Medicine</i>. 2013. 368(17):1585-1593.",
            "subspecialties" : "Cardiology",
            "expansion" : "Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block",
            "statusUsableDate" : "2017-06-01",
            "briefResultsDescription" : "Biventricular pacing superior to right ventricular pacing in patients with CHF with AV block",
            "published" : "2013-04-25",
            "pageName" : "BLOCK-HF",
            "diseases" : "Atrioventricular Block",
            "abbreviation" : "BLOCK-HF",
            "title" : "Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block",
            "pmid" : "23614585"
        },
        {
            "timestamp" : "2018-07-04T03:11:36Z",
            "briefDesignDescription" : "PharmD-guided BP reduction for black men in barbershops",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1717250",
            "pageid" : 3578,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1717250",
            "trainingLevel" : "Resident",
            "citation" : "Victor RG, <i>et al</i>. \"A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops\". <i>The New England Journal of Medicine</i>. 2018. 378(14):1291-1301.",
            "subspecialties" : "Cardiology",
            "expansion" : "Blood-Pressure Reduction in Black Barbershops",
            "statusUsableDate" : "2018-04-05",
            "briefResultsDescription" : "Pharmacist intervention with health promotion superior to health promotion alone",
            "published" : "2018-04-05",
            "pageName" : "Blood Pressure Reduction in Black Barbershops",
            "diseases" : "Hypertension",
            "abbreviation" : "Blood-Pressure Reduction in Black Barbershops",
            "title" : "A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops",
            "pmid" : "29527973"
        },
        {
             "timestamp" : "2018-01-17T21:45:20Z",
             "briefDesignDescription" : "LMWH bridging for surgery in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501035",
             "pageid" : 2402,
             "pageid" : 2402,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501035",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501035",
Line 427: Line 1,058:
             "subspecialties" : "Cardiology;Hematology",
             "subspecialties" : "Cardiology;Hematology",
             "expansion" : "Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for Elective Invasive Procedure or Surgery",
             "expansion" : "Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for Elective Invasive Procedure or Surgery",
            "statusUsableDate" : "2015-07-01",
             "briefResultsDescription" : "LMWH bridging didn't reduce VTE but increased bleeding",
             "briefResultsDescription" : "LMWH bridging didn't reduce VTE but increased bleeding",
             "published" : "2015-06-22",
             "published" : "2015-06-22",
Line 434: Line 1,066:
             "title" : "Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation",
             "title" : "Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation",
             "pmid" : "26095867"
             "pmid" : "26095867"
        },
        {
            "timestamp" : "2017-12-03T22:33:53Z",
            "briefDesignDescription" : "Vemurafenib in BRAF V600+ melanoma",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1103782",
            "pageid" : 2391,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1103782",
            "trainingLevel" : "Fellow",
            "citation" : "Chapman BP, <i>et al</i>. \"Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation\". <i>The New England Journal of Medicine</i>. 2011. 364(26):2507-2516.",
            "subspecialties" : "Oncology",
            "expansion" : "BRAF Inhibitor in Melanoma 3",
            "statusUsableDate" : "2015-07-01",
            "briefResultsDescription" : "Vemurafenib improves survival in BRAF V600-mutated melanoma",
            "published" : "2011-06-30",
            "pageName" : "BRIM-3",
            "diseases" : "Melanoma",
            "abbreviation" : "BRIM-3",
            "title" : "Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation",
            "pmid" : "21639808"
         },
         },
         {
         {
Line 445: Line 1,096:
             "subspecialties" : "Rheumatology",
             "subspecialties" : "Rheumatology",
             "expansion" : "Computer Assisted Management in Early Rheumatoid Arthritis",
             "expansion" : "Computer Assisted Management in Early Rheumatoid Arthritis",
            "statusUsableDate" : "2017-11-30",
             "briefResultsDescription" : "Intensive methotrexate dosing better than conventional",
             "briefResultsDescription" : "Intensive methotrexate dosing better than conventional",
             "published" : "2007-11-01",
             "published" : "2007-11-01",
Line 452: Line 1,104:
             "title" : "Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)",
             "title" : "Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)",
             "pmid" : "17519278"
             "pmid" : "17519278"
        },
        {
            "timestamp" : "2017-12-03T22:34:40Z",
            "briefDesignDescription" : "Light therapy vs. SSRI for SAD",
            "fulltexturl" : "http://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2006.163.5.805",
            "pageid" : 2173,
            "pdfurl" : "http://ajp.psychiatryonline.org/doi/pdf/10.1176/ajp.2006.163.5.805",
            "trainingLevel" : "Intern",
            "citation" : "Lam RW, <i>et al</i>. \"The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder\". <i>The American Journal of Psychiatry</i>. 2006. 165(5):805-812.",
            "subspecialties" : "Psychiatry",
            "expansion" : null,
            "statusUsableDate" : "2015-04-01",
            "briefResultsDescription" : "No difference between light therapy and SSRI in SAD",
            "published" : "2006-05-01",
            "pageName" : "Can-SAD",
            "diseases" : "Seasonal Affective Disorder;Depression",
            "abbreviation" : "Can-SAD",
            "title" : "The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder",
            "pmid" : "16648320"
         },
         },
         {
         {
Line 463: Line 1,134:
             "subspecialties" : "Emergency Medicine;Neurology",
             "subspecialties" : "Emergency Medicine;Neurology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "GCS score, skull fracture, emesis, age, amnesia, and mechanism predict risk",
             "briefResultsDescription" : "GCS score, skull fracture, emesis, age, amnesia, and mechanism predict risk",
             "published" : "2001-05-05",
             "published" : "2001-05-05",
Line 481: Line 1,153:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)",
             "expansion" : "Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)",
            "statusUsableDate" : "2017-10-01",
             "briefResultsDescription" : "Canakinumab reduces cardiovascular events in patients with previous MI",
             "briefResultsDescription" : "Canakinumab reduces cardiovascular events in patients with previous MI",
             "published" : "2017-08-27",
             "published" : "2017-08-27",
Line 488: Line 1,161:
             "title" : "Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease",
             "title" : "Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease",
             "pmid" : "28845751"
             "pmid" : "28845751"
        },
        {
            "timestamp" : "2017-12-03T22:33:58Z",
            "briefDesignDescription" : "Canagliflozin for CV outcomes in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611925",
            "pageid" : 2952,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611925",
            "trainingLevel" : "intern",
            "citation" : "Neal B, <i>et al</i>. \"Canagliflozin and cardiovascular and renal events in type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2017. 377(7):644-657.",
            "subspecialties" : "Endocrinology;Cardiology;Nephrology",
            "expansion" : "Canagliflozin Cardiovascular Assessment Study",
            "statusUsableDate" : "2017-08-01",
            "briefResultsDescription" : "Canagliflozin reduces CV events compared to placebo in patients with type 2 diabetes",
            "published" : "2017-08-17",
            "pageName" : "CANVAS",
            "diseases" : "Diabetes Mellitus",
            "abbreviation" : "CANVAS",
            "title" : "Canagliflozin and cardiovascular and renal events in type 2 diabetes",
            "pmid" : "28605608"
         },
         },
         {
         {
Line 499: Line 1,191:
             "subspecialties" : "Infectious Disease",
             "subspecialties" : "Infectious Disease",
             "expansion" : "Community-Acquired Pneumonia—Study on the Initial Treatment with Antibiotics of Lower Respiratory Tract Infections",
             "expansion" : "Community-Acquired Pneumonia—Study on the Initial Treatment with Antibiotics of Lower Respiratory Tract Infections",
            "statusUsableDate" : "2018-03-08",
             "briefResultsDescription" : "Beta-lactam alone is noninferior to quinolone or beta-lactam+macrolide",
             "briefResultsDescription" : "Beta-lactam alone is noninferior to quinolone or beta-lactam+macrolide",
             "published" : "2015-04-02",
             "published" : "2015-04-02",
Line 517: Line 1,210:
             "subspecialties" : "Neurology;Cardiology",
             "subspecialties" : "Neurology;Cardiology",
             "expansion" : "Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events",
             "expansion" : "Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Clopidogrel reduces risk of cardiovascular events",
             "briefResultsDescription" : "Clopidogrel reduces risk of cardiovascular events",
             "published" : "1996-11-16",
             "published" : "1996-11-16",
Line 526: Line 1,220:
         },
         },
         {
         {
             "timestamp" : "2018-08-10T15:33:15Z",
             "timestamp" : "2017-12-03T22:33:59Z",
             "briefDesignDescription" : "Catheter ablation vs. standard therapy in AF+HF",
             "briefDesignDescription" : "Preop coronary revascularization if stable CAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1707855",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041905",
             "pageid" : 3533,
             "pageid" : 1332,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1707855",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041905",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Marrouche NF, <i>et al</i>. \"Catheter Ablation for Atrial Fibrillation with Heart Failure\". <i>The New England Journal of Medicine</i>. 2018. 378(5):417-27.",
            "citation" : "McFalls EO, <i>et al</i>. \"Coronary-artery revascularization before elective major vascular surgery\". <i>The New England Journal of Medicine</i>. 2004. 351(27):2795-2804.",
             "subspecialties" : "Cardiology",
            "subspecialties" : "Cardiology;Preventive Medicine",
            "expansion" : "",
            "statusUsableDate" : "2015-09-01",
            "briefResultsDescription" : "Preop coronary revascularization doesn't reduce mortality",
            "published" : "2004-12-30",
            "pageName" : "CARP",
            "diseases" : "Coronary Artery Disease;Cardiac Risk Assessment",
            "abbreviation" : "CARP",
            "title" : "Coronary-artery revascularization before elective major vascular surgery",
            "pmid" : "15625331"
        },
        {
            "timestamp" : "2017-12-03T22:34:00Z",
            "briefDesignDescription" : "Ultrafiltration in decompensated HF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1210357",
            "pageid" : 1356,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1210357",
            "trainingLevel" : "Resident",
            "citation" : "Bart BA, <i>et al</i>. \"Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome\". <i>The New England Journal of Medicine</i>. 2012. 367(24):2296-2304.",
            "subspecialties" : "Cardiology",
            "expansion" : "Cardiorenal Rescue Study in Acute Decompensated Heart Failure",
            "statusUsableDate" : "2013-05-01",
            "briefResultsDescription" : "Ultrafiltration worse then meds in acute HF",
            "published" : "2012-12-13",
            "pageName" : "CARRESS-HF",
            "diseases" : "Heart Failure",
            "abbreviation" : "CARRESS-HF",
            "title" : "Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome",
            "pmid" : "23131078"
        },
        {
            "timestamp" : "2017-12-03T22:34:01Z",
            "briefDesignDescription" : "Antiarrhythmics post-MI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199103213241201",
            "pageid" : 1110,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199103213241201",
            "trainingLevel" : "Resident",
            "citation" : "Echt DS, <i>et al</i>. \"Mortality and morbidity in patients receiving encainide, flecainide, or placebo\". <i>The New England Journal of Medicine</i>. 1991. 324(12):781-788.",
            "subspecialties" : "Cardiology",
            "expansion" : "Cardiac Arrhythmia Suppression Trial",
            "statusUsableDate" : "2012-12-01",
            "briefResultsDescription" : "Antiarrhythmics increase mortality",
            "published" : "1991-03-21",
            "pageName" : "CAST I",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : "CAST I",
            "title" : "Mortality and morbidity in patients receiving encainide, flecainide, or placebo",
            "pmid" : "1900101"
        },
        {
            "timestamp" : "2018-08-10T15:33:15Z",
            "briefDesignDescription" : "Catheter ablation vs. standard therapy in AF+HF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1707855",
            "pageid" : 3533,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1707855",
            "trainingLevel" : "Resident",
             "citation" : "Marrouche NF, <i>et al</i>. \"Catheter Ablation for Atrial Fibrillation with Heart Failure\". <i>The New England Journal of Medicine</i>. 2018. 378(5):417-27.",
             "subspecialties" : "Cardiology",
             "expansion" : "Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation",
             "expansion" : "Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation",
            "statusUsableDate" : "2018-02-08",
             "briefResultsDescription" : "Catheter ablation superior to standard therapy in AF and HF",
             "briefResultsDescription" : "Catheter ablation superior to standard therapy in AF and HF",
             "published" : "2018-02-01",
             "published" : "2018-02-01",
Line 542: Line 1,294:
             "title" : "Catheter Ablation for Atrial Fibrillation with Heart Failure",
             "title" : "Catheter Ablation for Atrial Fibrillation with Heart Failure",
             "pmid" : "29385358"
             "pmid" : "29385358"
        },
        {
            "timestamp" : "2017-12-03T22:34:03Z",
            "briefDesignDescription" : "Antipsychotics in schizophrenia",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa051688",
            "pageid" : 419,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa051688",
            "trainingLevel" : "Resident",
            "citation" : "Lieberman JA, <i>et al</i>. \"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia\". <i>The New England Journal of Medicine</i>. 2005. 353(12):1209-23.",
            "subspecialties" : "Psychiatry",
            "expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness",
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "Olanzapine ↓discontinuations but ↑metabolic syndrome, and perphenazine ˜ atypicals",
            "published" : "2005-09-22",
            "pageName" : "CATIE",
            "diseases" : "Schizophrenia",
            "abbreviation" : "CATIE",
            "title" : "Effectiveness of antipsychotic drugs in patients with chronic schizophrenia",
            "pmid" : "16172203"
        },
        {
            "timestamp" : "2017-12-03T22:34:04Z",
            "briefDesignDescription" : "Antipsychotics in dementia with psychosis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061240",
            "pageid" : 2724,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061240",
            "trainingLevel" : "Intern",
            "citation" : "Schneider LS, <i>et al</i>. \"Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease\". <i>The New England Journal of Medicine</i>. 2006. 355(15):1525-38.",
            "subspecialties" : "Psychiatry",
            "expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness–Alzheimer's Disease",
            "statusUsableDate" : "2016-04-01",
            "briefResultsDescription" : "Antipsychotics no better than placebo",
            "published" : "2006-10-12",
            "pageName" : "CATIE-AD",
            "diseases" : "Dementia;Alzheimer Disease;Psychosis",
            "abbreviation" : "CATIE-AD",
            "title" : "Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease",
            "pmid" : "17035647"
        },
        {
            "timestamp" : "2017-12-03T22:34:05Z",
            "briefDesignDescription" : "Ranibizumab vs. bevacizumab for macular degeneration",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102673",
            "pageid" : 2250,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102673",
            "trainingLevel" : "Resident",
            "citation" : "The CATT Research Group Writers. \"Ranibizumab and bevacizumab for neovascular age-related macular degeneration\". <i>The New England Journal of Medicine</i>. 2011. 364(20):1897-1908.",
            "subspecialties" : "Ophthalmology",
            "expansion" : "Comparison of Age-Related Macular Degeneration Treatment Trails",
            "statusUsableDate" : "2014-10-01",
            "briefResultsDescription" : "Ranibizumab vs. bevacizumab similar even when comparing monthly vs. PRN scheduling",
            "published" : "2011-05-19",
            "pageName" : "CATT",
            "diseases" : "Macular Degeneration",
            "abbreviation" : "CATT",
            "title" : "Ranibizumab and bevacizumab for neovascular age-related macular degeneration",
            "pmid" : "21526923"
        },
        {
            "timestamp" : "2017-12-03T22:34:06Z",
            "briefDesignDescription" : "Cangrelor during urgent or elective PCI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300815",
            "pageid" : 2935,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300815",
            "trainingLevel" : "Fellow",
            "citation" : "Bhatt DL, <i>et al</i>. \"Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events\". <i>The New England Journal of Medicine</i>. 2013. 368(14):1303-1313.",
            "subspecialties" : "Cardiology;Interventional cardiology",
            "expansion" : "Cangrelor versus standard therapy to achieve optimal management of platelet inhibition",
            "statusUsableDate" : "2017-06-01",
            "briefResultsDescription" : "Cangrelor reduces rate of ischemic events during PCI",
            "published" : "2013-04-04",
            "pageName" : "CHAMPION PHOENIX",
            "diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : "CHAMPION PHOENIX",
            "title" : "Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events",
            "pmid" : "23473369"
         },
         },
         {
         {
Line 553: Line 1,381:
             "subspecialties" : "Neurology",
             "subspecialties" : "Neurology",
             "expansion" : "Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events",
             "expansion" : "Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events",
            "statusUsableDate" : "2013-07-01",
             "briefResultsDescription" : "ASA/clopidogrel decreases stroke rates compared to ASA alone in TIA and high-risk CVA",
             "briefResultsDescription" : "ASA/clopidogrel decreases stroke rates compared to ASA alone in TIA and high-risk CVA",
             "published" : "2013-07-04",
             "published" : "2013-07-04",
Line 571: Line 1,400:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance",
             "expansion" : "Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance",
            "statusUsableDate" : "2014-10-01",
             "briefResultsDescription" : "Combination therapy no better than aspirin alone, more bleeding",
             "briefResultsDescription" : "Combination therapy no better than aspirin alone, more bleeding",
             "published" : "2006-04-20",
             "published" : "2006-04-20",
Line 580: Line 1,410:
         },
         },
         {
         {
             "timestamp" : "2018-04-14T12:16:19Z",
            "timestamp" : "2017-12-03T22:34:11Z",
             "briefDesignDescription" : "LMWH vs. warfarin in cancer VTE",
            "briefDesignDescription" : "ARB plus ACE-I in HF",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2914283-3/fulltext",
            "pageid" : 2126,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603142833.pdf",
            "trainingLevel" : "Intern",
            "citation" : "McMurray JJ, <i>et al</i>. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial\". <i>The Lancet</i>. 2003. 362(9386):767-771.",
            "subspecialties" : "Cardiology",
            "expansion" : null,
            "statusUsableDate" : "2014-08-01",
            "briefResultsDescription" : "Adding ARB to ACE-I reduces CV events and HF hospitalizations",
            "published" : "2003-09-06",
            "pageName" : "CHARM-Added",
            "diseases" : "Heart Failure",
            "abbreviation" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Added",
            "title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial",
            "pmid" : "13678869"
        },
        {
            "timestamp" : "2017-12-03T22:34:16Z",
            "briefDesignDescription" : "ARBs in HFpEF",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14285-7/fulltext",
            "pageid" : 2381,
            "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14285-7.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Yusuf S, <i>et al</i>. \"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial\". <i>The Lancet</i>. 2003. 362(9386):777-781.",
            "subspecialties" : "Cardiology",
            "expansion" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved",
            "statusUsableDate" : "2015-06-01",
            "briefResultsDescription" : "Candesartan modestly reduces HF admissions but does not affect CV mortality",
            "published" : "2003-09-06",
            "pageName" : "CHARM-Preserved",
            "diseases" : "Heart Failure",
            "abbreviation" : "CHARM-Preserved",
            "title" : "Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial",
            "pmid" : "13678871"
        },
        {
            "timestamp" : "2017-12-03T22:34:42Z",
            "briefDesignDescription" : "Nivolumab in solid tumors",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200690",
            "pageid" : 2220,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200690",
            "trainingLevel" : "Resident",
            "citation" : "Topalian SL, <i>et al</i>. \"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer\". <i>The New England Journal of Medicine</i>. 2012. 366(26):2443-54.",
            "subspecialties" : "Oncology",
            "expansion" : "",
            "statusUsableDate" : "2014-10-01",
            "briefResultsDescription" : "Nivolumab was well tolerated, yielded durable remissions in about 30% of patients",
            "published" : "2012-06-28",
            "pageName" : "CheckMate-003",
            "diseases" : "Melanoma;Lung Cancer;Renal Cell Carcinoma",
            "abbreviation" : "",
            "title" : "Safety, activity, and immune correlates of anti-PD-1 antibody in cancer",
            "pmid" : "22658127"
        },
        {
            "timestamp" : "2017-12-03T22:34:18Z",
            "briefDesignDescription" : "Free long-acting reversible contraception in teens",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1400506",
            "pageid" : 2233,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1400506",
            "trainingLevel" : "Student",
            "citation" : "Secura GM, <i>et al</i>. \"Provision of no-cost, long-acting contraception and teenage pregnancy\". <i>The New England Journal of Medicine</i>. 2014. 371(14):1316-1326.",
            "subspecialties" : "Gynecology;Preventive Medicine;Obstetrics",
            "expansion" : "CHOICE is not an abbreviation per a communication with the research team",
            "statusUsableDate" : "2014-10-01",
            "briefResultsDescription" : "LARC reduced pregnancy, live births, and abortions",
            "published" : "2014-10-02",
            "pageName" : "CHOICE",
            "diseases" : "Unplanned Pregnancy",
            "abbreviation" : "CHOICE",
            "title" : "Provision of no-cost, long-acting contraception and teenage pregnancy",
            "pmid" : "25271604"
        },
        {
            "timestamp" : "2017-12-03T22:34:20Z",
            "briefDesignDescription" : "EPO in CKD with anemia",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa065485",
            "pageid" : 422,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa065485",
            "trainingLevel" : "Resident",
            "citation" : "Singh, AK <i>et al</i>. \"Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease\". <i>The New England Journal of Medicine</i>. 2006. 355(20):2085-2098.",
            "subspecialties" : "Nephrology;Hematology",
            "expansion" : "Correction of Hemoglobin and Outcomes in Renal Insufficiency",
            "statusUsableDate" : "2012-05-01",
            "briefResultsDescription" : "Increased morbidity/mortality with higher hgb targets",
            "published" : "2006-11-16",
            "pageName" : "CHOIR",
            "diseases" : "Chronic Kidney Disease;Anemia",
            "abbreviation" : "CHOIR",
            "title" : "Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease",
            "pmid" : "17108343"
        },
        {
            "timestamp" : "2017-12-03T22:34:21Z",
            "briefDesignDescription" : "PFO closure in cryptogenic stroke",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009639",
            "pageid" : 1093,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009639",
            "trainingLevel" : "Fellow",
            "citation" : "Furlan AJ, <i>et al</i>. \"Closure or medical therapy for cryptogenic stroke with patent foramen ovale\". <i>The New England Journal of Medicine</i>. 2012. 366(11):991-999.",
            "subspecialties" : "Neurology;Cardiology",
            "expansion" : "Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale",
            "statusUsableDate" : "2013-01-01",
            "briefResultsDescription" : "PFO closure does not reduce recurrent stroke",
            "published" : "2012-03-15",
            "pageName" : "CLOSURE I",
            "diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
            "abbreviation" : "CLOSURE I",
            "title" : "Closure or medical therapy for cryptogenic stroke with patent foramen ovale",
            "pmid" : "22417252"
        },
        {
             "timestamp" : "2018-04-14T12:16:19Z",
             "briefDesignDescription" : "LMWH vs. warfarin in cancer VTE",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa025313",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa025313",
             "pageid" : 13,
             "pageid" : 13,
Line 589: Line 1,533:
             "subspecialties" : "Hematology;Oncology",
             "subspecialties" : "Hematology;Oncology",
             "expansion" : "Comparison of Low Molecular Weight Heparin Versus Oral Anticoagulant Therapy for Long Term Anticoagulation in Cancer Patients With Venous Thromboembolism",
             "expansion" : "Comparison of Low Molecular Weight Heparin Versus Oral Anticoagulant Therapy for Long Term Anticoagulation in Cancer Patients With Venous Thromboembolism",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "LMWH reduces VTE recurrence in cancer VTE without increasing bleeding risk",
             "briefResultsDescription" : "LMWH reduces VTE recurrence in cancer VTE without increasing bleeding risk",
             "published" : "2003-07-10",
             "published" : "2003-07-10",
Line 596: Line 1,541:
             "title" : "Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer",
             "title" : "Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer",
             "pmid" : "12853587"
             "pmid" : "12853587"
        },
        {
            "timestamp" : "2017-12-03T22:34:23Z",
            "briefDesignDescription" : "PPI plus clopidogrel in CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007964",
            "pageid" : 313,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007964",
            "trainingLevel" : "Resident",
            "citation" : "Bhatt DL, <i>et al</i>. \"Clopidogrel with or without omeprazole in coronary artery disease\". <i>The New England Journal of Medicine</i>. 2010. 363(20):1909-17.",
            "subspecialties" : "Cardiology",
            "expansion" : "Clopidogrel and the Optimization of Gastrointestinal Events Trial",
            "statusUsableDate" : "2012-04-01",
            "briefResultsDescription" : "PPIs reduce bleeding but do not increase CV events when given with clopidogrel",
            "published" : "2010-11-11",
            "pageName" : "COGENT",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "COGENT",
            "title" : "Clopidogrel with or without omeprazole in coronary artery disease",
            "pmid" : "20925534"
         },
         },
         {
         {
Line 607: Line 1,571:
             "subspecialties" : "Preventive Medicine;Gastroenterology;Oncology",
             "subspecialties" : "Preventive Medicine;Gastroenterology;Oncology",
             "expansion" : null,
             "expansion" : null,
            "statusUsableDate" : "2016-07-01",
             "briefResultsDescription" : "FIT is noninferior to colonoscopy for detecting colon cancer",
             "briefResultsDescription" : "FIT is noninferior to colonoscopy for detecting colon cancer",
             "published" : "2012-02-23",
             "published" : "2012-02-23",
Line 625: Line 1,590:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Carvedilol Or Metoprolol European Trial",
             "expansion" : "Carvedilol Or Metoprolol European Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Carvedilol extends survival in HFrEF",
             "briefResultsDescription" : "Carvedilol extends survival in HFrEF",
             "published" : "2003-07-05",
             "published" : "2003-07-05",
Line 643: Line 1,609:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "ClOpidogrel and Metoprolol in Myocardial Infarction Trial / Second Chinese Cardiac Study",
             "expansion" : "ClOpidogrel and Metoprolol in Myocardial Infarction Trial / Second Chinese Cardiac Study",
            "statusUsableDate" : "2013-05-01",
             "briefResultsDescription" : "High-dose IV and PO metoprolol increases cardiogenic shock",
             "briefResultsDescription" : "High-dose IV and PO metoprolol increases cardiogenic shock",
             "published" : "2005-11-05",
             "published" : "2005-11-05",
Line 661: Line 1,628:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2018-03-11",
             "briefResultsDescription" : "FFR-guided complete revascularization superior to infarct-related artery only PCI",
             "briefResultsDescription" : "FFR-guided complete revascularization superior to infarct-related artery only PCI",
             "published" : "2017-03-30",
             "published" : "2017-03-30",
Line 679: Line 1,647:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Cardiovascular Outcomes for People Using Anticoagulation Stratgies",
             "expansion" : "Cardiovascular Outcomes for People Using Anticoagulation Stratgies",
            "statusUsableDate" : "2017-09-01",
             "briefResultsDescription" : "Rivaroxaban + ASA superior to placebo + ASA for secondary prevention of CAD",
             "briefResultsDescription" : "Rivaroxaban + ASA superior to placebo + ASA for secondary prevention of CAD",
             "published" : "2017-08-27",
             "published" : "2017-08-27",
Line 697: Line 1,666:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Cooperative North Scandinavian Enalapril Survival Study",
             "expansion" : "Cooperative North Scandinavian Enalapril Survival Study",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Enalapril ↓mortality in NYHA class IV HFrEF",
             "briefResultsDescription" : "Enalapril ↓mortality in NYHA class IV HFrEF",
             "published" : "1987-06-04",
             "published" : "1987-06-04",
Line 715: Line 1,685:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Carvedilol Prospective Randomized Cumulative Survival",
             "expansion" : "Carvedilol Prospective Randomized Cumulative Survival",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Carvedilol reduces mortality and HF hospitalizations in severe NYHA class III-IV HFrEF",
             "briefResultsDescription" : "Carvedilol reduces mortality and HF hospitalizations in severe NYHA class III-IV HFrEF",
             "published" : "2002-10-22",
             "published" : "2002-10-22",
Line 724: Line 1,695:
         },
         },
         {
         {
             "timestamp" : "2017-12-14T14:38:53Z",
            "timestamp" : "2017-12-03T22:34:30Z",
            "briefDesignDescription" : "Rosuvastatin in ischemic HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706201",
            "pageid" : 524,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706201",
            "trainingLevel" : "Resident",
            "citation" : "Kjekshus J, <i>et al</i>. \"Rosuvastatin in Older Patients with Systolic Heart Failure\". <i>The New England Journal of Medicine</i>. 2007. 357(22):2248-61.",
            "subspecialties" : "Cardiology",
            "expansion" : "Controlled Rosuvastatin Multinational Trial in Heart Failure",
            "statusUsableDate" : "2012-07-01",
            "briefResultsDescription" : "Statins confer no survival benefit but may reduce hospitalizations in ischemic HFrEF",
            "published" : "2007-11-29",
            "pageName" : "CORONA",
            "diseases" : "Heart Failure;Hyperlipidemia",
            "abbreviation" : "CORONA",
            "title" : "Rosuvastatin in Older Patients with Systolic Heart Failure",
            "pmid" : "17984166"
        },
        {
            "timestamp" : "2018-03-03T22:13:51Z",
            "briefDesignDescription" : "Hydrocortisone in septic shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa071366",
            "pageid" : 4,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa071366",
            "trainingLevel" : "Student",
            "citation" : "Sprung CL, <i>et al</i>. \"Hydrocortisone therapy for patients with septic shock\". <i>New England Journal of Medicine</i>. 2008. 358(2):111-24.",
            "subspecialties" : "Critical Care;Endocrinology",
            "expansion" : "Corticosteroid Therapy of Septic Shock",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Improved survival of hydrocortisone in septic shock",
            "published" : "2008-01-10",
            "pageName" : "CORTICUS",
            "diseases" : "Sepsis;Shock",
            "abbreviation" : "CORTICUS",
            "title" : "Hydrocortisone therapy for patients with septic shock",
            "pmid" : "18184957"
        },
        {
             "timestamp" : "2017-12-14T14:38:53Z",
             "briefDesignDescription" : "PCI vs. medical therapy in CAD",
             "briefDesignDescription" : "PCI vs. medical therapy in CAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa070829",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa070829",
Line 733: Line 1,742:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation",
             "expansion" : "Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "No difference between PCI and OMT in stable CAD",
             "briefResultsDescription" : "No difference between PCI and OMT in stable CAD",
             "published" : "2007-04-12",
             "published" : "2007-04-12",
Line 740: Line 1,750:
             "title" : "Optimal medical therapy with or without PCI for stable coronary disease",
             "title" : "Optimal medical therapy with or without PCI for stable coronary disease",
             "pmid" : "17387127"
             "pmid" : "17387127"
        },
        {
            "timestamp" : "2017-12-03T22:34:43Z",
            "briefDesignDescription" : "Cranberry in for prevention of pyuria and bacteriuria",
            "fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.16141",
            "pageid" : 2900,
            "pdfurl" : "",
            "trainingLevel" : "student",
            "citation" : "Juthani-Mehta M, <i>et al</i>. \"Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial\". <i>JAMA</i>. 2016. 316(18):1879-1887.",
            "subspecialties" : "Infectious Disease;Geriatrics",
            "expansion" : "",
            "statusUsableDate" : "2017-04-01",
            "briefResultsDescription" : "Cranberry ineffective to prevent pyuria and bacteriuria",
            "published" : "2016-11-08",
            "pageName" : "Cranberry for prevention of pyuria and bacteriuria",
            "diseases" : "Bacteriuria;Pyuria",
            "abbreviation" : "",
            "title" : "Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial",
            "pmid" : "27787564"
        },
        {
            "timestamp" : "2017-12-03T22:34:31Z",
            "briefDesignDescription" : "Tranexamic acid in trauma",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960835-5/fulltext",
            "pageid" : 490,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673610608355.pdf",
            "trainingLevel" : "resident",
            "citation" : "Shakur H, <i>et al</i>. \"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage\". <i>The Lancet</i>. 2010. 376(9734):23-32.",
            "subspecialties" : "Emergency Medicine;Surgery",
            "expansion" : "Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2",
            "statusUsableDate" : "2013-07-01",
            "briefResultsDescription" : "Tranexamic acid reduces 4-week mortality",
            "published" : "2010-07-03",
            "pageName" : "CRASH-2",
            "diseases" : "Trauma",
            "abbreviation" : "CRASH-2",
            "title" : "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage",
            "pmid" : "20554319"
         },
         },
         {
         {
Line 751: Line 1,799:
             "subspecialties" : "Surgery;Neurology;Cardiology",
             "subspecialties" : "Surgery;Neurology;Cardiology",
             "expansion" : "Carotid Revascularization Endarterectomy vs. Stenting Trial",
             "expansion" : "Carotid Revascularization Endarterectomy vs. Stenting Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "No difference in stroke/MI/death; stenting ↑perioperative stroke but ↓perioperative MI",
             "briefResultsDescription" : "No difference in stroke/MI/death; stenting ↑perioperative stroke but ↓perioperative MI",
             "published" : "2010-07-01",
             "published" : "2010-07-01",
Line 758: Line 1,807:
             "title" : "Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis",
             "title" : "Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis",
             "pmid" : "20505173"
             "pmid" : "20505173"
        },
        {
            "timestamp" : "2017-12-03T22:34:32Z",
            "briefDesignDescription" : "Colloids vs. crystalloids in shock",
            "fulltexturl" : "http://bit.ly/1kLbQWJ",
            "pageid" : 1768,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/928522/joi130081.pdf",
            "trainingLevel" : "resident",
            "citation" : "Annane D, <i>et al</i>. \"Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock\". <i>The Journal of the American Medical Association</i>. 2013. 310(17):1809-1817.",
            "subspecialties" : "Critical Care",
            "expansion" : "Colloids Versus Crystalloids for the Resuscitation of the Critically Ill",
            "statusUsableDate" : "2014-07-01",
            "briefResultsDescription" : "Colloids no different from crystalloids in mortality",
            "published" : "2013-11-06",
            "pageName" : "CRISTAL",
            "diseases" : "Shock",
            "abbreviation" : "CRISTAL",
            "title" : "Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock",
            "pmid" : "24108515"
        },
        {
            "timestamp" : "2017-12-03T22:34:33Z",
            "briefDesignDescription" : "Captopril in T1DM nephropathy",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199311113292004",
            "pageid" : 1591,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199311113292004",
            "trainingLevel" : "Student",
            "citation" : "Lewis EJ, <i>et al</i>. \"The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.\". <i>The New England Journal of Medicine</i>. 1993. 329(20):1456-1462.",
            "subspecialties" : "Nephrology;Endocrinology",
            "expansion" : "Collaborative Study Group Captopril Trial",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "Captopril reduces T1DM nephropathy progression",
            "published" : "1993-11-11",
            "pageName" : "CSG Captopril Trial",
            "diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
            "abbreviation" : "CSG Captopril Trial",
            "title" : "The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.",
            "pmid" : "8413456"
         },
         },
         {
         {
Line 769: Line 1,856:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock",
             "expansion" : "Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock",
            "statusUsableDate" : "2017-11-01",
             "briefResultsDescription" : "Culprit-only PCI superior to multivessel PCI in cardiogenic shock",
             "briefResultsDescription" : "Culprit-only PCI superior to multivessel PCI in cardiogenic shock",
             "published" : "2017-10-30",
             "published" : "2017-10-30",
Line 778: Line 1,866:
         },
         },
         {
         {
             "timestamp" : "2018-05-31T17:39:19Z",
             "timestamp" : "2017-12-03T22:34:36Z",
             "briefDesignDescription" : "Culprit lesion PCI vs. FFR in multivessel CAD",
             "briefDesignDescription" : "Clopidogrel in UA/NSTEMI",
             "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60648-1/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010746",
             "pageid" : 3634,
             "pageid" : 921,
             "pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60648-1.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010746",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Engstrom T, <i>et al</i>. \"Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease\". <i>The Lancet</i>. 2015. 386:665-71.",
             "citation" : "Yusuf S, <i>et al</i>. \"Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation\". <i>The New England Journal of Medicine</i>. 2001. 345(7):494-502.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Third Danish Study of Optimal Acute Treatment of Patients with STEMI: Primary PCI in Multivessel Disease",
            "expansion" : "Clopidogrel in Unstable Angina to Prevent Recurrent Events",
             "briefResultsDescription" : "FFR-guided revascularization was superior to culprit-lesion only in multivessel CAD",
            "statusUsableDate" : "2012-12-01",
            "briefResultsDescription" : "Clopidogrel reduces CV events but increases bleeding in UA/NSTEMI",
            "published" : "2001-08-16",
            "pageName" : "CURE",
            "diseases" : "Acute Coronary Syndrome",
            "abbreviation" : "CURE",
            "title" : "Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation",
            "pmid" : "11519503"
        },
        {
            "timestamp" : "2017-12-03T22:34:45Z",
            "briefDesignDescription" : "Culprit lesion-only vs. complete revascularization",
            "fulltexturl" : "http://www.onlinejacc.org/content/65/10/963",
            "pageid" : 2880,
            "pdfurl" : "http://www.onlinejacc.org/content/accj/65/10/963.full.pdf?download",
            "trainingLevel" : "Resident",
            "citation" : "Gershlick <i>et al</i>. \"Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease\". <i>J Am Coll Cardiol</i>. 2015. 65(10):963-72.",
            "subspecialties" : "Cardiology",
            "expansion" : "Complete Versus Lesion-Only Primary PCI Trial",
            "statusUsableDate" : "2017-02-01",
            "briefResultsDescription" : "Complete revascularization superior to culprit lesion-only revascularization",
            "published" : "2015-03-17",
            "pageName" : "CvLPRIT",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "CvLPRIT",
            "title" : "Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease",
            "pmid" : "25766941"
        },
        {
            "timestamp" : "2017-12-03T22:34:37Z",
            "briefDesignDescription" : "Pulse cyclophosphamide for ANCA vasculitis",
            "fulltexturl" : null,
            "pageid" : 2338,
            "pdfurl" : "http://annals.org/data/Journals/AIM/20182/0000605-200905190-00004.pdf",
            "trainingLevel" : "Fellow",
            "citation" : "de Groot K, <i>et al</i>. \"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial\". <i>Annals of Internal Medicine</i>. 2009. 150(10):670-680.",
            "subspecialties" : "Rheumatology;Nephrology",
            "expansion" : null,
            "statusUsableDate" : "2015-03-01",
            "briefResultsDescription" : "Pulse no worse than daily cyclophosphamide",
            "published" : "2009-05-19",
            "pageName" : "CYCLOPS",
            "diseases" : "Vasculitis",
            "abbreviation" : "CYCLOPS",
            "title" : "Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial",
            "pmid" : "19451574"
        },
        {
            "timestamp" : "2018-01-13T01:32:16Z",
            "briefDesignDescription" : "Cytisine vs. NRT for tobacco abuse",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407764",
            "pageid" : 2319,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407764",
            "trainingLevel" : "Intern",
            "citation" : "Walker N, <i>et al</i>. \"Cytisine versus nicotine for smoking cessation\". <i>The New England Journal of Medicine</i>. 2014. 371(25):2353-2362.",
            "subspecialties" : "Pulmonology;Preventive Medicine",
            "expansion" : null,
            "statusUsableDate" : "2015-01-01",
            "briefResultsDescription" : "Cytisine superior to NRT for abstinence at 1 month",
            "published" : "2014-12-18",
            "pageName" : "Cytisine for Smoking Cessation",
            "diseases" : "Tobacco Abuse",
            "abbreviation" : null,
            "title" : "Cytisine versus nicotine for smoking cessation",
            "pmid" : "25517706"
        },
        {
            "timestamp" : "2017-12-03T22:34:39Z",
            "briefDesignDescription" : "Hematocrit thresholds in PV",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208500",
            "pageid" : 2709,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208500",
            "trainingLevel" : "Fellow",
            "citation" : "Marchioli R, <i>et al</i>. \"Cardiovascular events and intensity of treatment in polycythemia vera\". <i>The New England Journal of Medicine</i>. 2013. 368(1):22-33.",
            "subspecialties" : "Hematology;Cardiology",
            "expansion" : "Cytoreductive Therapy in Polycythemia Vera",
            "statusUsableDate" : "2016-02-01",
            "briefResultsDescription" : "Fewer vascular events with hematocrit <45% compared to 45-50%",
            "published" : "2013-01-03",
            "pageName" : "CYTO-PV",
            "diseases" : "Polycythemia Vera;Myeloproliferative Neoplasms",
            "abbreviation" : "CYTO-PV",
            "title" : "Cardiovascular events and intensity of treatment in polycythemia vera",
            "pmid" : "23216616"
        },
        {
            "timestamp" : "2017-12-03T22:35:01Z",
            "briefDesignDescription" : "Scheduled daily sedation holidays in intubated patients",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200005183422002",
            "pageid" : 1554,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200005183422002",
            "trainingLevel" : "Intern",
            "citation" : "Kress JP, <i>et al</i>. \"Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation\". <i>The New England Journal of Medicine</i>. 2000. 342(20):1471-1477.",
            "subspecialties" : "Critical Care;Pulmonology",
            "expansion" : "",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "Sedation holidays reduce intubated, ICU, hospital days",
            "published" : "2000-05-18",
            "pageName" : "Daily ICU Sedation Holidays",
            "diseases" : "Respiratory Failure",
            "abbreviation" : "",
            "title" : "Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation",
            "pmid" : "10816184"
        },
        {
            "timestamp" : "2018-05-31T17:39:19Z",
            "briefDesignDescription" : "Culprit lesion PCI vs. FFR in multivessel CAD",
            "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60648-1/fulltext",
            "pageid" : 3634,
            "pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60648-1.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Engstrom T, <i>et al</i>. \"Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease\". <i>The Lancet</i>. 2015. 386:665-71.",
            "subspecialties" : "Cardiology",
             "expansion" : "Third Danish Study of Optimal Acute Treatment of Patients with STEMI: Primary PCI in Multivessel Disease",
            "statusUsableDate" : "2018-05-28",
             "briefResultsDescription" : "FFR-guided revascularization was superior to culprit-lesion only in multivessel CAD",
             "published" : "2015-08-15",
             "published" : "2015-08-15",
             "pageName" : "DANAMI-3 PRIMULTI",
             "pageName" : "DANAMI-3 PRIMULTI",
Line 796: Line 1,999:
         },
         },
         {
         {
             "timestamp" : "2017-12-14T19:02:26Z",
            "timestamp" : "2017-12-03T22:34:48Z",
            "briefDesignDescription" : "ICD vs. standard care in NICM and LVEF ≤35%",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1608029",
            "pageid" : 2815,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1608029",
            "trainingLevel" : "Resident",
            "citation" : "Kober L, <i>et al</i>. \"Defibrillator implantation in patients with nonischemic systolic heart failure\". <i>The New England Journal of Medicine</i>. 2016. epub 2016-08-28:1-10.",
            "subspecialties" : "Cardiology",
            "expansion" : "Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality",
            "statusUsableDate" : "2016-09-01",
            "briefResultsDescription" : "ICD not better than standard of care in NICM and LVEF ≤35%",
            "published" : "2016-08-28",
            "pageName" : "DANISH",
            "diseases" : "Ventricular Tachycardia",
            "abbreviation" : "DANISH",
            "title" : "Defibrillator implantation in patients with nonischemic systolic heart failure",
            "pmid" : "27571011"
        },
        {
            "timestamp" : "2017-12-03T22:34:50Z",
            "briefDesignDescription" : "Aspirin/clopidogrel duration after PCI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409312",
            "pageid" : 2264,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409312",
            "trainingLevel" : "Intern",
            "citation" : "Mauri L, <i>et al</i>. \"Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents\". <i>The New England Journal of Medicine</i>. 2014. 371(23):2155-2166.",
            "subspecialties" : "Cardiology",
            "expansion" : "Dual Antiplatelet Therapy",
            "statusUsableDate" : "2014-11-01",
            "briefResultsDescription" : "Longer duration reduces stent thrombosis, MI, stroke, but increases mortality/bleeding",
            "published" : "2014-11-16",
            "pageName" : "DAPT",
            "diseases" : "Coronary Artery Disease;Myocardial Infarction;Stroke",
            "abbreviation" : "DAPT",
            "title" : "Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents",
            "pmid" : "25399658"
        },
        {
             "timestamp" : "2017-12-14T19:02:26Z",
             "briefDesignDescription" : "DASH diet in HTN",
             "briefDesignDescription" : "DASH diet in HTN",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199704173361601",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199704173361601",
Line 805: Line 2,046:
             "subspecialties" : "Cardiology;Nephrology",
             "subspecialties" : "Cardiology;Nephrology",
             "expansion" : "Dietary Approaches to Stop Hypertension",
             "expansion" : "Dietary Approaches to Stop Hypertension",
            "statusUsableDate" : "2012-04-01",
             "briefResultsDescription" : "DASH diet reduces SBP and DBP",
             "briefResultsDescription" : "DASH diet reduces SBP and DBP",
             "published" : "1997-04-17",
             "published" : "1997-04-17",
Line 812: Line 2,054:
             "title" : "A clinical trial of the effects of dietary patterns on blood pressure",
             "title" : "A clinical trial of the effects of dietary patterns on blood pressure",
             "pmid" : "9099655"
             "pmid" : "9099655"
        },
        {
            "timestamp" : "2017-12-03T22:34:54Z",
            "briefDesignDescription" : "Dual-chamber vs. ventricular backup pacing in ICD patients",
            "fulltexturl" : "http://jama.jamanetwork.com/article.aspx?volume",
            "pageid" : 2713,
            "pdfurl" : null,
            "trainingLevel" : "Resident",
            "citation" : "Wilkoff BL, <i>et al</i>. \"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator\". <i>Journal of the American Medical Association</i>. 2002. 288(24):3115-3123.",
            "subspecialties" : "Cardiology",
            "expansion" : "Dual-chamber pacing or ventricular backup pacing in ICD patients",
            "statusUsableDate" : "2016-08-01",
            "briefResultsDescription" : "Ventricular backup pacemaker superior to dual-chamber pacemaker",
            "published" : "2002-12-25",
            "pageName" : "DAVID",
            "diseases" : "Bradycardia",
            "abbreviation" : "DAVID",
            "title" : "Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator",
            "pmid" : "12495391"
         },
         },
         {
         {
Line 823: Line 2,084:
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Diabetes Control and Complications Trial",
             "expansion" : "Diabetes Control and Complications Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Intensive therapy delays microvascular but not macrovascular complications in T1DM",
             "briefResultsDescription" : "Intensive therapy delays microvascular but not macrovascular complications in T1DM",
             "published" : "1993-09-30",
             "published" : "1993-09-30",
Line 841: Line 2,103:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation",
             "expansion" : "Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "ICD reduced risk of arrhythmogenic sudden death, but not overall mortality",
             "briefResultsDescription" : "ICD reduced risk of arrhythmogenic sudden death, but not overall mortality",
             "published" : "2004-05-20",
             "published" : "2004-05-20",
Line 859: Line 2,122:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction",
             "expansion" : "Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction",
            "statusUsableDate" : "2017-10-01",
             "briefResultsDescription" : "Oxygen doesn't improve 1 year survival in MI",
             "briefResultsDescription" : "Oxygen doesn't improve 1 year survival in MI",
             "published" : "2017-09-28",
             "published" : "2017-09-28",
Line 877: Line 2,141:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Digitalis Investigation Group",
             "expansion" : "Digitalis Investigation Group",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Reduced hospitalizations, no mortality benefit",
             "briefResultsDescription" : "Reduced hospitalizations, no mortality benefit",
             "published" : "1997-02-20",
             "published" : "1997-02-20",
Line 884: Line 2,149:
             "title" : "The effect of digoxin on mortality and morbidity in patients with heart failure",
             "title" : "The effect of digoxin on mortality and morbidity in patients with heart failure",
             "pmid" : "9036306"
             "pmid" : "9036306"
        },
        {
            "timestamp" : "2017-12-03T22:34:58Z",
            "briefDesignDescription" : "ICD for ICM shortly after MI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041489",
            "pageid" : 1743,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041489",
            "trainingLevel" : "Resident",
            "citation" : "Hohnloser SH, <i>et al</i>. \"Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 2004. 351(24):2481-2488.",
            "subspecialties" : "Cardiology",
            "expansion" : "Defibrillator in Acute Myocardial Infarction Trial",
            "statusUsableDate" : "2016-04-01",
            "briefResultsDescription" : "ICD reduces arrhythmia but not mortality",
            "published" : "2004-12-09",
            "pageName" : "DINAMIT",
            "diseases" : "Heart Failure;Myocardial Infarction",
            "abbreviation" : "DINAMIT",
            "title" : "Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction",
            "pmid" : "15590950"
        },
        {
            "timestamp" : "2017-12-03T22:35:00Z",
            "briefDesignDescription" : "Diuretic dosing in acute HF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005419",
            "pageid" : 1457,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005419",
            "trainingLevel" : "Intern",
            "citation" : "Felker GM, <i>et al</i>. \"Diuretic strategies in patients with acute decompensated heart failure\". <i>The New England Journal of Medicine</i>. 2011. 364(9):797-805.",
            "subspecialties" : "Cardiology",
            "expansion" : "Diuretic Optimization Strategies Evaluation",
            "statusUsableDate" : "2013-06-01",
            "briefResultsDescription" : "High-dose better than low-dose, continuous infusions no better than intermittent IV boluses",
            "published" : "2011-03-03",
            "pageName" : "DOSE",
            "diseases" : "Heart Failure",
            "abbreviation" : "DOSE",
            "title" : "Diuretic strategies in patients with acute decompensated heart failure",
            "pmid" : "21366472"
         },
         },
         {
         {
Line 895: Line 2,198:
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Diabetes Prevention Program",
             "expansion" : "Diabetes Prevention Program",
            "statusUsableDate" : "2018-05-31",
             "briefResultsDescription" : "Metformin and intensive lifestyle reduce incidence of diabetes",
             "briefResultsDescription" : "Metformin and intensive lifestyle reduce incidence of diabetes",
             "published" : "2002-02-07",
             "published" : "2002-02-07",
Line 902: Line 2,206:
             "title" : "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin",
             "title" : "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin",
             "pmid" : "11832527"
             "pmid" : "11832527"
        },
        {
            "timestamp" : "2017-12-03T22:35:03Z",
            "briefDesignDescription" : "Duct tape vs. cryotherapy for warts",
            "fulltexturl" : "",
            "pageid" : 1579,
            "pdfurl" : "http://archpedi.jamanetwork.com/data/Journals/PEDS/5052/POA20075.pdf",
            "trainingLevel" : "Student",
            "citation" : "Focht DR, <i>et al</i>. \"The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)\". <i>Archives of Pediatric and Adolescent Medicine</i>. 2002. 156:971-974.",
            "subspecialties" : "Pediatrics;Dermatology",
            "expansion" : "",
            "statusUsableDate" : "2013-07-01",
            "briefResultsDescription" : "Duct tape superior to cryotherapy for wart resolution",
            "published" : "2002-10-01",
            "pageName" : "Duct Tape for Treatment of the Common Wart",
            "diseases" : "Warts",
            "abbreviation" : "",
            "title" : "The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)",
            "pmid" : "12361440"
         },
         },
         {
         {
Line 913: Line 2,236:
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2013-02-01",
             "briefResultsDescription" : "Fecal transplant better than vancomycin in C. difficile",
             "briefResultsDescription" : "Fecal transplant better than vancomycin in C. difficile",
             "published" : "2013-01-31",
             "published" : "2013-01-31",
Line 920: Line 2,244:
             "title" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
             "title" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
             "pmid" : "23323867"
             "pmid" : "23323867"
        },
        {
            "timestamp" : "2017-12-03T22:35:32Z",
            "briefDesignDescription" : "Palliative care in NSCLC",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000678",
            "pageid" : 466,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000678",
            "trainingLevel" : "Intern",
            "citation" : "Temel JS, <i>et al</i>. \"Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer\". <i>The New England Journal of Medicine</i>. 2010. 363(8):733-742.",
            "subspecialties" : "Oncology;Palliative Care",
            "expansion" : null,
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "Palliative care ↑mood, ↑QOL, ↑survival, ↓aggressive care",
            "published" : "2010-08-19",
            "pageName" : "Early Palliative Care",
            "diseases" : "Lung Cancer",
            "abbreviation" : null,
            "title" : "Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer",
            "pmid" : "20818875"
         },
         },
         {
         {
Line 931: Line 2,274:
             "subspecialties" : "Gastroenterology;Interventional Radiology",
             "subspecialties" : "Gastroenterology;Interventional Radiology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2018-08-30",
             "briefResultsDescription" : "Early TIPS reduces rates of treatment failure and improves 1-year survival",
             "briefResultsDescription" : "Early TIPS reduces rates of treatment failure and improves 1-year survival",
             "published" : "2010-06-24",
             "published" : "2010-06-24",
Line 949: Line 2,293:
             "subspecialties" : "Neurology",
             "subspecialties" : "Neurology",
             "expansion" : "European Cooperative Acute Stroke Study III",
             "expansion" : "European Cooperative Acute Stroke Study III",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Alteplase improves neurological outcomes at 3 months",
             "briefResultsDescription" : "Alteplase improves neurological outcomes at 3 months",
             "published" : "2008-09-25",
             "published" : "2008-09-25",
Line 958: Line 2,303:
         },
         },
         {
         {
             "timestamp" : "2013-03-12T08:18:42Z",
            "timestamp" : "2017-12-03T22:35:06Z",
             "briefDesignDescription" : "Intensive glycemic therapy in T1DM",
            "briefDesignDescription" : "CEA in symptomatic carotid stenosis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052187",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2909292-1",
            "pageid" : 2354,
            "pdfurl" : "",
            "trainingLevel" : "Intern",
            "citation" : "ECST Writers. \"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)\". <i>The Lancet</i>. 1998. 351(9113):1379-1387.",
            "subspecialties" : "Surgery;Neurology",
            "expansion" : "European Carotid Surgery Trial",
            "statusUsableDate" : "2015-08-01",
            "briefResultsDescription" : "CEA improves outcomes in patients with ≥80% symptomatic carotid stenosis",
            "published" : "1998-05-09",
            "pageName" : "ECST",
            "diseases" : "Carotid Stenosis;Stroke",
            "abbreviation" : "ECST",
            "title" : "Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)",
            "pmid" : "9593407"
        },
        {
             "timestamp" : "2013-03-12T08:18:42Z",
             "briefDesignDescription" : "Intensive glycemic therapy in T1DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052187",
             "pageid" : 136,
             "pageid" : 136,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052187",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052187",
Line 967: Line 2,331:
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Epidemiology of Diabetes Interventions and Complications",
             "expansion" : "Epidemiology of Diabetes Interventions and Complications",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Intensive therapy associated with fewer cardiovascular complications",
             "briefResultsDescription" : "Intensive therapy associated with fewer cardiovascular complications",
             "published" : "2005-12-22",
             "published" : "2005-12-22",
Line 974: Line 2,339:
             "title" : "Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes",
             "title" : "Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes",
             "pmid" : "16371630"
             "pmid" : "16371630"
        },
        {
            "timestamp" : "2017-12-03T22:35:08Z",
            "briefDesignDescription" : "Rivaroxaban after VTE treatment",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700518",
            "pageid" : 2927,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700518",
            "trainingLevel" : "Resident",
            "citation" : "Weitz JI, <i>et al</i>. \"Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2017. 376(13):1211-22.",
            "subspecialties" : "Hematology",
            "expansion" : "Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic Venous Thromboembolism",
            "statusUsableDate" : "2017-07-01",
            "briefResultsDescription" : "Rivaroxaban reduces recurrent VTE",
            "published" : "2017-03-30",
            "pageName" : "EINSTEIN CHOICE",
            "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
            "abbreviation" : "EINSTEIN CHOICE",
            "title" : "Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism",
            "pmid" : "28316279"
        },
        {
            "timestamp" : "2017-12-03T22:35:09Z",
            "briefDesignDescription" : "Rivaroxaban vs. warfarin in PE",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1113572",
            "pageid" : 1519,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1113572",
            "trainingLevel" : "Student",
            "citation" : "Büller HR, <i>et al</i>. \"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism\". <i>The New England Journal of Medicine</i>. 2012. 366(14):1287-1297.",
            "subspecialties" : "Hematology;Pulmonology",
            "expansion" : "",
            "statusUsableDate" : "2013-07-01",
            "briefResultsDescription" : "Rivaroxaban is noninferior to warfarin in PE treatment",
            "published" : "2012-04-05",
            "pageName" : "EINSTEIN-PE",
            "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
            "abbreviation" : "EINSTEIN-PE",
            "title" : "Oral rivaroxaban for the treatment of symptomatic pulmonary embolism",
            "pmid" : "22449293"
        },
        {
            "timestamp" : "2018-05-27T16:17:38Z",
            "briefDesignDescription" : "Immunosuppression after kidney transplant",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067411",
            "pageid" : 2324,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067411",
            "trainingLevel" : "Resident",
            "citation" : "Ekberg H, <i>et al</i>. \"Reduced exposure to calcineurin inhibitors in renal transplantation\". <i>The New England Journal of Medicine</i>. 2007. 357(25):2562-2575.",
            "subspecialties" : "Nephrology",
            "expansion" : "Efficacy Limiting Toxicity Elimination-Symphony",
            "statusUsableDate" : "2015-02-01",
            "briefResultsDescription" : "Daclizumab, mycophenolate, steroids, and tacrolimus beneficial",
            "published" : "2007-12-20",
            "pageName" : "ELITE-Symphony",
            "diseases" : "Kidney Transplant",
            "abbreviation" : "ELITE-Symphony",
            "title" : "Reduced exposure to calcineurin inhibitors in renal transplantation",
            "pmid" : "18094377"
         },
         },
         {
         {
Line 985: Line 2,407:
             "subspecialties" : "Neurology;Cardiology",
             "subspecialties" : "Neurology;Cardiology",
             "expansion" : "30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event",
             "expansion" : "30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event",
            "statusUsableDate" : "2018-09-13",
             "briefResultsDescription" : "Extended EKG monitoring detects AF more frequently than 24-hour monitoring",
             "briefResultsDescription" : "Extended EKG monitoring detects AF more frequently than 24-hour monitoring",
             "published" : "2014-06-26",
             "published" : "2014-06-26",
Line 994: Line 2,417:
         },
         },
         {
         {
             "timestamp" : "2018-03-29T18:53:41Z",
            "timestamp" : "2017-12-03T22:35:13Z",
             "briefDesignDescription" : "Edoxaban vs. warfarin in AF",
            "briefDesignDescription" : "T-DM1 in metastatic breast cancer",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310907",
            "fulltexturl" : "http://www.nejm.org/doi/abs/10.1056/NEJMoa1209124",
             "pageid" : 2471,
            "pageid" : 1257,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310907",
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1209124",
             "trainingLevel" : "resident",
            "trainingLevel" : "fellow",
             "citation" : "Guigliano RP, <i>et al</i>. \"Edoxaban versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2013. 369(22):2093-2104.",
            "citation" : "Verma S, <i>et al</i>. \"Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer\". <i>The New England Journal of Medicine</i>. 2012. 367(19):1783-1791.",
            "subspecialties" : "Oncology",
            "expansion" : "Emtansine vs. Capecitabine+Lapatinib in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer",
            "statusUsableDate" : "2013-04-01",
            "briefResultsDescription" : "T-DM1 prolongs PFS in metastatic breast cancer",
            "published" : "2012-11-08",
            "pageName" : "EMILIA",
            "diseases" : "Breast Cancer",
            "abbreviation" : "EMILIA",
            "title" : "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer",
            "pmid" : "23020162"
        },
        {
            "timestamp" : "2017-12-03T22:35:14Z",
            "briefDesignDescription" : "Empagliflozin for CV outcomes in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1504720",
            "pageid" : 2448,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1504720",
            "trainingLevel" : "intern",
            "citation" : "Zinman B, <i>et al</i>. \"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2015. 373(22):2117-28.",
            "subspecialties" : "Cardiology;Endocrinology",
            "expansion" : "",
            "statusUsableDate" : "2015-10-01",
            "briefResultsDescription" : "Empagliflozin reduces mortality compared to placebo in patients with type 2 diabetes",
            "published" : "2015-09-17",
            "pageName" : "EMPA-REG OUTCOME",
            "diseases" : "Diabetes Mellitus",
            "abbreviation" : "EMPA-REG OUTCOME",
            "title" : "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",
            "pmid" : "26378978"
        },
        {
            "timestamp" : "2017-12-03T22:35:16Z",
            "briefDesignDescription" : "Eplerenone in HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009492",
            "pageid" : 120,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009492",
            "trainingLevel" : "Resident",
            "citation" : "Zannad F, <i>et al</i>. \"Eplerenone in patients with systolic heart failure and mild symptoms\". <i>The New England Journal of Medicine</i>. 2011. 364(1):11-21.",
            "subspecialties" : "Cardiology",
            "expansion" : "Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure",
            "statusUsableDate" : "2012-08-01",
            "briefResultsDescription" : "Eplerenone reduces CV deaths and HF hospitalizations",
            "published" : "2011-01-06",
            "pageName" : "EMPHASIS-HF",
            "diseases" : "Heart Failure",
            "abbreviation" : "EMPHASIS-HF",
            "title" : "Eplerenone in patients with systolic heart failure and mild symptoms",
            "pmid" : "21073363"
        },
        {
             "timestamp" : "2018-03-29T18:53:41Z",
             "briefDesignDescription" : "Edoxaban vs. warfarin in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310907",
             "pageid" : 2471,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310907",
             "trainingLevel" : "resident",
             "citation" : "Guigliano RP, <i>et al</i>. \"Edoxaban versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2013. 369(22):2093-2104.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48",
             "expansion" : "Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48",
            "statusUsableDate" : "2017-02-01",
             "briefResultsDescription" : "Edoxaban  is noninferior to warfarin to prevent stroke or thromboembolism",
             "briefResultsDescription" : "Edoxaban  is noninferior to warfarin to prevent stroke or thromboembolism",
             "published" : "2013-11-28",
             "published" : "2013-11-28",
Line 1,021: Line 2,502:
             "subspecialties" : "Orthopedics;Hematology;General Medicine",
             "subspecialties" : "Orthopedics;Hematology;General Medicine",
             "expansion" : "Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II",
             "expansion" : "Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II",
            "statusUsableDate" : "2018-03-29",
             "briefResultsDescription" : "Aspirin similar to rivaroxaban for prevention of VTE",
             "briefResultsDescription" : "Aspirin similar to rivaroxaban for prevention of VTE",
             "published" : "2018-02-22",
             "published" : "2018-02-22",
Line 1,039: Line 2,521:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study",
             "expansion" : "Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Mortality benefit of eplerenone post MI with HFrEF",
             "briefResultsDescription" : "Mortality benefit of eplerenone post MI with HFrEF",
             "published" : "2003-04-03",
             "published" : "2003-04-03",
Line 1,046: Line 2,529:
             "title" : "Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction",
             "title" : "Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction",
             "pmid" : "12668699"
             "pmid" : "12668699"
        },
        {
            "timestamp" : "2017-12-03T22:35:20Z",
            "briefDesignDescription" : "PSA for prostate cancer screening",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810084",
            "pageid" : 2796,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810084",
            "trainingLevel" : "Intern",
            "citation" : "Schröder FH, <i>et al</i>. \"Screening and Prostate-Cancer Mortality in a Randomized European Study\". <i>The New England Journal of Medicine</i>. 2009. 360(13):1320-1328.",
            "subspecialties" : "Urology;Oncology;Preventive Medicine",
            "expansion" : "European Randomized Study of Screening for Prostate Cancer",
            "statusUsableDate" : "2016-07-01",
            "briefResultsDescription" : "Decrease in prostate cancer mortality but increased risk of overdiagnosis and overtreatment",
            "published" : "2009-07-09",
            "pageName" : "ERSPC",
            "diseases" : "Prostate Cancer",
            "abbreviation" : "ERSPC",
            "title" : "Screening and Prostate-Cancer Mortality in a Randomized European Study",
            "pmid" : "19297566"
        },
        {
            "timestamp" : "2017-12-03T22:35:21Z",
            "briefDesignDescription" : "PA catheters in acute HF management",
            "fulltexturl" : null,
            "pageid" : 1407,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4994/JOC50108.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Binanay C, <i>et al</i>. \"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness\". <i>JAMA</i>. 2005. 294(13):1625-1633.",
            "subspecialties" : "Cardiology;Critical Care",
            "expansion" : "Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness",
            "statusUsableDate" : "2013-06-01",
            "briefResultsDescription" : "Routine PA catheters no better than clinical assessment",
            "published" : "2005-10-05",
            "pageName" : "ESCAPE",
            "diseases" : "Heart Failure",
            "abbreviation" : "ESCAPE",
            "title" : "Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness",
            "pmid" : "16204662"
        },
        {
            "timestamp" : "2017-12-03T22:35:22Z",
            "briefDesignDescription" : "ASA+dipyridamole in secondary stroke prevention",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2806%2968734-5/fulltext",
            "pageid" : 1726,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606687345.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Halkes PH, <i>et al</i>. \"Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial\". <i>The Lancet</i>. 2006. 367(9523):1665-1673.",
            "subspecialties" : "Neurology",
            "expansion" : "European/Australasian Stroke Prevention in Reversible Ischaemia Trial",
            "statusUsableDate" : "2013-11-01",
            "briefResultsDescription" : "ASA+dipyridamole better than ASA for secondary stroke prevention",
            "published" : "2006-05-20",
            "pageName" : "ESPRIT",
            "diseases" : "Stroke;Transient Ischemic Attack",
            "abbreviation" : "ESPRIT",
            "title" : "Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial",
            "pmid" : "16714187"
        },
        {
            "timestamp" : "2017-12-03T22:35:24Z",
            "briefDesignDescription" : "LMWH vs. UFH in UA/NSTEMI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199708143370702",
            "pageid" : 1443,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199708143370702",
            "trainingLevel" : "Intern",
            "citation" : "Cohen M, <i>et al</i>. \"A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease\". <i>The New England Journal of Medicine</i>. 1997. 337(7):447-452.",
            "subspecialties" : "Cardiology",
            "expansion" : "Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group",
            "statusUsableDate" : "2013-05-01",
            "briefResultsDescription" : "LMWH reduces 14-day mortality, MI, or recurrent angina in UA/NSTEMI",
            "published" : "1997-08-14",
            "pageName" : "ESSENCE",
            "diseases" : "Acute Coronary Syndrome",
            "abbreviation" : "ESSENCE",
            "title" : "A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease",
            "pmid" : "9250846"
        },
        {
            "timestamp" : "2017-12-03T22:35:25Z",
            "briefDesignDescription" : "Ticagrelor vs. clopidogrel in symptomatic PAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611688",
            "pageid" : 2878,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611688",
            "trainingLevel" : "Resident",
            "citation" : "Hiatt WR <i>et al</i>. \"Ticagrelor versus clopidogrel in symptomatic peripheral artery disease\". <i>New Engl J Med</i>. 2017. 376(1):32-40.",
            "subspecialties" : "Cardiology",
            "expansion" : "Examining use of ticagrelor in peripheral artery disease",
            "statusUsableDate" : "2017-01-01",
            "briefResultsDescription" : "Ticagrelor not superior to clopidogrel in symptomatic PAD",
            "published" : "2017-01-05",
            "pageName" : "EUCLID (Ticagrelor)",
            "diseases" : "Peripheral Arterial Disease",
            "abbreviation" : "EUCLID",
            "title" : "Ticagrelor versus clopidogrel in symptomatic peripheral artery disease",
            "pmid" : "27959717"
         },
         },
         {
         {
Line 1,057: Line 2,635:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease",
             "expansion" : "European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease",
            "statusUsableDate" : "2018-02-08",
             "briefResultsDescription" : "Perindopril reduces composite of CV mortality, MI, or cardiac arrest",
             "briefResultsDescription" : "Perindopril reduces composite of CV mortality, MI, or cardiac arrest",
             "published" : "2003-09-06",
             "published" : "2003-09-06",
Line 1,064: Line 2,643:
             "title" : "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease",
             "title" : "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease",
             "pmid" : "13678872"
             "pmid" : "13678872"
        },
        {
            "timestamp" : "2017-12-03T22:35:34Z",
            "briefDesignDescription" : "Dexamethasone in meningitis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021334",
            "pageid" : 306,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021334",
            "trainingLevel" : "Resident",
            "citation" : "de Gans JD, <i>et al</i>. \"Dexamethasone in Adults with Bacterial Meningitis\". <i>The New England Journal of Medicine</i>. 2002. 347(20):1549-1556.",
            "subspecialties" : "Infectious Disease;Neurology",
            "expansion" : "European Dexamethasone Study",
            "statusUsableDate" : "2012-04-01",
            "briefResultsDescription" : "Dexamethasone reduces mortality in bacterial meningitis",
            "published" : "2002-11-14",
            "pageName" : "European Dexamethasone Study",
            "diseases" : "Meningitis",
            "abbreviation" : "EDS",
            "title" : "Dexamethasone in Adults with Bacterial Meningitis",
            "pmid" : "12432041"
        },
        {
            "timestamp" : "2017-12-03T22:35:27Z",
            "briefDesignDescription" : "Tolvaptan in acute HF in HFrEF",
            "fulltexturl" : null,
            "pageid" : 1345,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5131/joc70029_1319_1331.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Konstam MA, <i>et al</i>. \"The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure\". <i>The Journal of the American Medical Association</i>. 2007. 297(12):1319-1331.",
            "subspecialties" : "Cardiology",
            "expansion" : "Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan",
            "statusUsableDate" : "2013-06-01",
            "briefResultsDescription" : "No benefit from tolvaptan when given for 60 days after acute HF episode",
            "published" : "2007-03-28",
            "pageName" : "EVEREST-Outcomes",
            "diseases" : "Heart Failure",
            "abbreviation" : "EVEREST",
            "title" : "The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure",
            "pmid" : "17384437"
        },
        {
            "timestamp" : "2017-12-03T22:35:28Z",
            "briefDesignDescription" : "Cinacalcet in ESRD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205624",
            "pageid" : 2426,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205624",
            "trainingLevel" : "Resident",
            "citation" : "Chertow GM, <i>et al</i>. \"Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis\". <i>The New England Journal of Medicine</i>. 2012. 367(26):2482-2494.",
            "subspecialties" : "Nephrology",
            "expansion" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
            "statusUsableDate" : "2015-10-01",
            "briefResultsDescription" : "Cinecalcet did not reduce CV events in ESRD",
            "published" : "2012-12-27",
            "pageName" : "EVOLVE",
            "diseases" : "Chronic Kidney Disease;Cardiovascular Disease",
            "abbreviation" : "EVOLVE",
            "title" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
            "pmid" : "23121374"
        },
        {
            "timestamp" : "2017-12-03T22:35:29Z",
            "briefDesignDescription" : "CABG vs. PCI in left main CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1610227",
            "pageid" : 2868,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1610227",
            "trainingLevel" : "Resident",
            "citation" : "Stone GW, <i>et al</i>. \"Everolimus-eluting stents or bypass surgery for left main coronary artery disease\". <i>The New England Journal of Medicine</i>. 2016. 375(23):2223-35.",
            "subspecialties" : "Cardiology",
            "expansion" : "XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL)",
            "statusUsableDate" : "2016-12-01",
            "briefResultsDescription" : "PCI noninferior to CABG in left main CAD with low-intermediate anatomic complexity",
            "published" : "2016-12-08",
            "pageName" : "EXCEL",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "EXCEL",
            "title" : "Everolimus-eluting stents or bypass surgery for left main coronary artery disease",
            "pmid" : "27797291"
        },
        {
            "timestamp" : "2017-12-03T22:35:31Z",
            "briefDesignDescription" : "Omalizumab in severe allergic asthma",
            "fulltexturl" : null,
            "pageid" : 1434,
            "pdfurl" : "http://annals.org/data/Journals/AIM/20231/0000605-201105030-00002.pdf",
            "trainingLevel" : "Fellow",
            "citation" : "Hanania NA, <i>et al</i>. \"Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial\". <i>Annals of Internal Medicine</i>. 2011. 154(9):573-582.",
            "subspecialties" : "Allergy and Immunology;Pulmonology;Pediatrics",
            "expansion" : "A Study of Omalizumab/Xolair in Subjects With Moderate to Severe Persistent Asthma",
            "statusUsableDate" : "2013-10-01",
            "briefResultsDescription" : "Omalizumab reduces asthma exacerbations",
            "published" : "2011-05-03",
            "pageName" : "EXTRA",
            "diseases" : "Asthma",
            "abbreviation" : "EXTRA",
            "title" : "Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial",
            "pmid" : "21536936"
         },
         },
         {
         {
Line 1,075: Line 2,749:
             "subspecialties" : "Critical Care",
             "subspecialties" : "Critical Care",
             "expansion" : "Fluids and Catheters Treatment Trial",
             "expansion" : "Fluids and Catheters Treatment Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Mortality benefit of conservative fluid management in ALI/ARDS",
             "briefResultsDescription" : "Mortality benefit of conservative fluid management in ALI/ARDS",
             "published" : "2006-06-15",
             "published" : "2006-06-15",
Line 1,093: Line 2,768:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Fractional Flow Reserve versus Angiography for Multivessel Evaluation",
             "expansion" : "Fractional Flow Reserve versus Angiography for Multivessel Evaluation",
            "statusUsableDate" : "2012-10-01",
             "briefResultsDescription" : "FFR reduces composite of death, nonfatal MI, urgent revascularization",
             "briefResultsDescription" : "FFR reduces composite of death, nonfatal MI, urgent revascularization",
             "published" : "2009-01-15",
             "published" : "2009-01-15",
Line 1,111: Line 2,787:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "FFR vs. Angiographyfor Multivessel Evaluation 2",
             "expansion" : "FFR vs. Angiographyfor Multivessel Evaluation 2",
            "statusUsableDate" : "2012-11-01",
             "briefResultsDescription" : "FFR-guided PCI reduces urgent revascularization",
             "briefResultsDescription" : "FFR-guided PCI reduces urgent revascularization",
             "published" : "2012-09-13",
             "published" : "2012-09-13",
Line 1,118: Line 2,795:
             "title" : "Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease",
             "title" : "Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease",
             "pmid" : "22924638"
             "pmid" : "22924638"
        },
        {
            "timestamp" : "2017-12-03T22:35:38Z",
            "briefDesignDescription" : "Fluid resuscitation in Sub-Saharan Africa",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1101549",
            "pageid" : 1860,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1101549",
            "trainingLevel" : "Resident",
            "citation" : "Maitland K, <i>et al</i>. \"Mortality after fluid bolus in African children with severe infection\". <i>The New England Journal of Medicine</i>. 2011. 364(26):2483-2495.",
            "subspecialties" : "Pediatrics;Critical Care",
            "expansion" : "Fluid Expansion as Supportive Therapy",
            "statusUsableDate" : "2014-11-01",
            "briefResultsDescription" : "Albumin and saline increase mortality when compared to no fluids in this patient population",
            "published" : "2011-06-30",
            "pageName" : "FEAST",
            "diseases" : "Shock",
            "abbreviation" : "FEAST",
            "title" : "Mortality after fluid bolus in African children with severe infection",
            "pmid" : "21615299"
         },
         },
         {
         {
Line 1,129: Line 2,825:
             "subspecialties" : "Infectious Disease;Gastroenterology",
             "subspecialties" : "Infectious Disease;Gastroenterology",
             "expansion" : null,
             "expansion" : null,
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Fidaxomicin noninferior to vancomycin for cure, and resulted in 45% fewer recurrences",
             "briefResultsDescription" : "Fidaxomicin noninferior to vancomycin for cure, and resulted in 45% fewer recurrences",
             "published" : "2011-02-03",
             "published" : "2011-02-03",
Line 1,136: Line 2,833:
             "title" : "Fidaxomicin versus Vancomycin for Clostridium difficile Infection",
             "title" : "Fidaxomicin versus Vancomycin for Clostridium difficile Infection",
             "pmid" : "21288078"
             "pmid" : "21288078"
        },
        {
            "timestamp" : "2017-12-03T22:35:39Z",
            "briefDesignDescription" : "Cryoablation vs. RF ablation in pAF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602014",
            "pageid" : 2795,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602014",
            "trainingLevel" : "Resident",
            "citation" : "Kuck K, <i>et al</i>. \"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2016. 374(23):2235-45.",
            "subspecialties" : "Cardiology",
            "expansion" : "",
            "statusUsableDate" : "2016-07-01",
            "briefResultsDescription" : "Cryoablation equivalent to RF ablation in pAF",
            "published" : "2016-06-09",
            "pageName" : "FIRE AND ICE",
            "diseases" : "Atrial Fibrillation",
            "abbreviation" : "FIRE AND ICE",
            "title" : "Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation",
            "pmid" : "27042964"
        },
        {
            "timestamp" : "2017-12-03T22:35:41Z",
            "briefDesignDescription" : "LABA+LAMA vs. LABA+ICS in COPD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1516385",
            "pageid" : 2871,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1516385",
            "trainingLevel" : "Resident",
            "citation" : "Wedzicha JA, <i>et al</i>. \"Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD\". <i>The New England Journal of Medicine</i>. 2016. 374(23):2222-2234.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Effect of Indacaterol Glycopyronium Vs. Fluticasone Salmeterol on COPD Exacerbations",
            "statusUsableDate" : "2017-01-01",
            "briefResultsDescription" : "LABA+LAMA reduces COPD exacerbations",
            "published" : "2016-06-09",
            "pageName" : "FLAME (COPD)",
            "diseases" : "Emphysema;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease",
            "abbreviation" : "FLAME COPD",
            "title" : "Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD",
            "pmid" : "27181606"
         },
         },
         {
         {
Line 1,147: Line 2,882:
             "subspecialties" : "Neurology",
             "subspecialties" : "Neurology",
             "expansion" : "Fluoxetine for Motor Recovery after Acute Ischaemic Stroke",
             "expansion" : "Fluoxetine for Motor Recovery after Acute Ischaemic Stroke",
            "statusUsableDate" : "2015-08-01",
             "briefResultsDescription" : "Early fluoxetine improved motor outcomes post stroke",
             "briefResultsDescription" : "Early fluoxetine improved motor outcomes post stroke",
             "published" : "2011-02-01",
             "published" : "2011-02-01",
Line 1,165: Line 2,901:
             "subspecialties" : "Hematology;Surgery",
             "subspecialties" : "Hematology;Surgery",
             "expansion" : "Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair",
             "expansion" : "Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair",
            "statusUsableDate" : "2017-12-14",
             "briefResultsDescription" : "Liberal transfusions no better than restrictive",
             "briefResultsDescription" : "Liberal transfusions no better than restrictive",
             "published" : "2011-12-29",
             "published" : "2011-12-29",
Line 1,174: Line 2,911:
         },
         },
         {
         {
             "timestamp" : "2014-09-24T22:28:37Z",
            "timestamp" : "2017-12-03T22:35:44Z",
             "briefDesignDescription" : "Lisinopril in acute MI",
            "briefDesignDescription" : "Evolocumab for CVD events if atherosclerotic disease",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1615664",
            "pageid" : 2891,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1615664",
            "trainingLevel" : "Resident",
            "citation" : "Sabatine MS, <i>et al</i>. \"Evolocumab and clinical outcomes in patients with cardiovascular disease\". <i>The New England Journal of Medicine</i>. 2017. epub 2017-03-17:1-10.",
            "subspecialties" : "Cardiology",
            "expansion" : "Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk",
            "statusUsableDate" : "2017-03-01",
            "briefResultsDescription" : "Evolocumab reduces CV events in patients with atherosclerotic disease",
            "published" : "2017-03-17",
            "pageName" : "FOURIER",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "FOURIER",
            "title" : "Evolocumab and clinical outcomes in patients with cardiovascular disease",
            "pmid" : "28304224"
        },
        {
            "timestamp" : "2017-12-03T22:35:45Z",
            "briefDesignDescription" : "CABG vs. PCI for CAD in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211585",
            "pageid" : 2314,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211585",
            "trainingLevel" : "Resident",
            "citation" : "Farkouh ME, <i>et al</i>. \"Strategies for multivessel revascularization in patients with diabetes\". <i>The New England Journal of Medicine</i>. 2012. 367(25):2375-2384.",
            "subspecialties" : "Cardiology;Endocrinology",
            "expansion" : "Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease",
            "statusUsableDate" : "2016-04-01",
            "briefResultsDescription" : "CABG reduces death and revascularization rates but causes more strokes",
            "published" : "2012-12-20",
            "pageName" : "FREEDOM",
            "diseases" : "Coronary Artery Disease;Diabetes Mellitus",
            "abbreviation" : "FREEDOM",
            "title" : "Strategies for multivessel revascularization in patients with diabetes",
            "pmid" : "23121323"
        },
        {
            "timestamp" : "2017-12-03T22:35:48Z",
            "briefDesignDescription" : "Early invasive strategy in UA/NSTEMI",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07349-3/fulltext",
            "pageid" : 2451,
            "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(99)07349-3.pdf",
            "trainingLevel" : "Resident",
            "citation" : "FRISC Investigators. \"Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study\". <i>The Lancet</i>. 1999. 354(9180):708-15.",
            "subspecialties" : "Cardiology",
            "expansion" : "",
            "statusUsableDate" : "2015-11-01",
            "briefResultsDescription" : "Fewer recurrent MIs with early invasive strategy in high-risk patients",
            "published" : "1999-08-28",
            "pageName" : "FRISC-II",
            "diseases" : "Coronary Artery Disease;Myocardial Infarction;Acute Coronary Syndrome",
            "abbreviation" : "FRISC-II",
            "title" : "Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study",
            "pmid" : "10475181"
        },
        {
            "timestamp" : "2017-12-03T22:35:49Z",
            "briefDesignDescription" : "Risk factors for GI bleeds in ICU patients",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199402103300601",
            "pageid" : 391,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199402103300601",
            "trainingLevel" : "Intern",
            "citation" : "Cook DJ, <i>et al</i>. \"Risk factors for gastrointestinal bleeding in critically ill patients\". <i>The New England Journal of Medicine</i>. 1994. 330(6):337-381.",
            "subspecialties" : "Critical Care;Gastroenterology",
            "expansion" : null,
            "statusUsableDate" : "2013-10-01",
            "briefResultsDescription" : "Greatest risk for GI bleed with coagulopathy and mechanical ventilation",
            "published" : "1994-02-10",
            "pageName" : "GI bleeding in ICU patients",
            "diseases" : "Gastrointestinal Hemorrhage",
            "abbreviation" : null,
            "title" : "Risk factors for gastrointestinal bleeding in critically ill patients",
            "pmid" : "8284001"
        },
        {
             "timestamp" : "2014-09-24T22:28:37Z",
             "briefDesignDescription" : "Lisinopril in acute MI",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2894%2990232-1/abstract",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2894%2990232-1/abstract",
             "pageid" : 258,
             "pageid" : 258,
Line 1,183: Line 2,996:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico",
             "expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Lisinopril improves 6-week mortality",
             "briefResultsDescription" : "Lisinopril improves 6-week mortality",
             "published" : "1994-05-07",
             "published" : "1994-05-07",
Line 1,190: Line 3,004:
             "title" : "Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction",
             "title" : "Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction",
             "pmid" : "7910229"
             "pmid" : "7910229"
        },
        {
            "timestamp" : "2017-12-03T22:35:51Z",
            "briefDesignDescription" : "tPA in ACS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309023291001",
            "pageid" : 2177,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309023291001",
            "trainingLevel" : "Student",
            "citation" : "Topol E, <i>et al</i>. \"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 1993. 329(10):673-682.",
            "subspecialties" : "Cardiology",
            "expansion" : "Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries",
            "statusUsableDate" : "2014-09-01",
            "briefResultsDescription" : "tPA reduces mortality in ACS",
            "published" : "1993-09-03",
            "pageName" : "GUSTO",
            "diseases" : "Myocardial Infarction;Acute Coronary Syndrome",
            "abbreviation" : "GUSTO",
            "title" : "An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction",
            "pmid" : "8204123"
         },
         },
         {
         {
Line 1,201: Line 3,034:
             "subspecialties" : "Critical Care;Neurology;Cardiology",
             "subspecialties" : "Critical Care;Neurology;Cardiology",
             "expansion" : "Hypothermia After Cardiac Arrest",
             "expansion" : "Hypothermia After Cardiac Arrest",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Hypothermia improves neurologic outcomes and reduces mortality",
             "briefResultsDescription" : "Hypothermia improves neurologic outcomes and reduces mortality",
             "published" : "2002-02-21",
             "published" : "2002-02-21",
Line 1,208: Line 3,042:
             "title" : "Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest",
             "title" : "Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest",
             "pmid" : "11856793"
             "pmid" : "11856793"
        },
        {
            "timestamp" : "2017-12-03T22:35:53Z",
            "briefDesignDescription" : "Continuous-flow LVAD in heart failure",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909938#t",
            "pageid" : 2808,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909938",
            "trainingLevel" : "Fellow",
            "citation" : "Slaughter MS, <i>et al</i>. \"Advanced heart failure treated with continuous-flow left ventricular assist device\". <i>The New England Journal of Medicine</i>. 2009. 361(23):2241-2251.",
            "subspecialties" : "Cardiology",
            "expansion" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
            "statusUsableDate" : "2016-09-01",
            "briefResultsDescription" : "Continuous-flow LVAD improved survival free from stroke and device failure",
            "published" : "2009-12-03",
            "pageName" : "HEARTMATE II",
            "diseases" : "Heart Failure",
            "abbreviation" : "HEARTMATE II",
            "title" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
            "pmid" : "19920051"
         },
         },
         {
         {
Line 1,219: Line 3,072:
             "subspecialties" : "Critical Care;Infectious Disease",
             "subspecialties" : "Critical Care;Infectious Disease",
             "expansion" : "Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit",
             "expansion" : "Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit",
            "statusUsableDate" : "2017-09-01",
             "briefResultsDescription" : "Acetaminophen does not improves ICU outcomes",
             "briefResultsDescription" : "Acetaminophen does not improves ICU outcomes",
             "published" : "2015-12-03",
             "published" : "2015-12-03",
Line 1,237: Line 3,091:
             "subspecialties" : "Nephrology",
             "subspecialties" : "Nephrology",
             "expansion" : "Hemodialysis",
             "expansion" : "Hemodialysis",
            "statusUsableDate" : "2018-03-15",
             "briefResultsDescription" : "High dialysis dose and high-flux membrane did not reduce all-cause mortality",
             "briefResultsDescription" : "High dialysis dose and high-flux membrane did not reduce all-cause mortality",
             "published" : "2002-12-19",
             "published" : "2002-12-19",
Line 1,255: Line 3,110:
             "subspecialties" : "Oncology",
             "subspecialties" : "Oncology",
             "expansion" : "Herceptin Adjuvant Trial",
             "expansion" : "Herceptin Adjuvant Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Trastuzumab improves survival",
             "briefResultsDescription" : "Trastuzumab improves survival",
             "published" : "2005-10-20",
             "published" : "2005-10-20",
Line 1,273: Line 3,129:
             "subspecialties" : "Hematology;Pulmonology",
             "subspecialties" : "Hematology;Pulmonology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2018-02-01",
             "briefResultsDescription" : "Edoxaban noninferior to dalteparin in cancer VTE",
             "briefResultsDescription" : "Edoxaban noninferior to dalteparin in cancer VTE",
             "published" : "2018-02-15",
             "published" : "2018-02-15",
Line 1,291: Line 3,148:
             "subspecialties" : "Cardiology;Neurology",
             "subspecialties" : "Cardiology;Neurology",
             "expansion" : "Heart Outcomes Prevention Evaluation",
             "expansion" : "Heart Outcomes Prevention Evaluation",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Ramipril reduces death, MI, and stroke",
             "briefResultsDescription" : "Ramipril reduces death, MI, and stroke",
             "published" : "2000-01-20",
             "published" : "2000-01-20",
Line 1,300: Line 3,158:
         },
         },
         {
         {
             "timestamp" : "2018-08-14T17:41:27Z",
            "timestamp" : "2017-12-03T22:35:56Z",
             "briefDesignDescription" : "Hydrocortisone, Vit C, and thiamine in sepsis",
            "briefDesignDescription" : "Niacin in atherosclerotic disease",
             "fulltexturl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300955",
             "pageid" : 2946,
            "pageid" : 2329,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300955",
            "trainingLevel" : "Intern",
            "citation" : "Landray MJ <i>et al</i>. \"Effects of extended-release niacin with laropiprant in high-risk patients\". <i>The New England Journal of Medicine</i>. 2014. 371(3):203-212.",
            "subspecialties" : "Cardiology",
            "expansion" : "Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events",
            "statusUsableDate" : "2015-02-01",
            "briefResultsDescription" : "Niacin is poorly tolerated, doesn't reduce major vascular events",
            "published" : "2014-07-17",
            "pageName" : "HPS2-THRIVE",
            "diseases" : "Coronary Artery Disease;Peripheral Vascular Disease",
            "abbreviation" : "HPS2-THRIVE",
            "title" : "Effects of extended-release niacin with laropiprant in high-risk patients",
            "pmid" : "25014686"
        },
        {
            "timestamp" : "2017-12-03T22:35:58Z",
            "briefDesignDescription" : "Early ART in HIV",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1105243",
            "pageid" : 1010,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1105243",
            "trainingLevel" : "Resident",
            "citation" : "Cohen MS, <i>et al</i>. \"Prevention of HIV-1 Infection with Early Antiretroviral Therapy\". <i>The New England Journal of Medicine</i>. 2011. 365(6):493-505.",
            "subspecialties" : "Infectious Disease",
            "expansion" : "HIV Prevention Trials Network 052 Study",
            "statusUsableDate" : "2012-10-01",
            "briefResultsDescription" : "Reduced morbidity and HIV transmission",
            "published" : "2011-08-11",
            "pageName" : "HPTN 052",
            "diseases" : "HIV",
            "abbreviation" : "HPTN 052",
            "title" : "Prevention of HIV-1 Infection with Early Antiretroviral Therapy",
            "pmid" : "21767103"
        },
        {
            "timestamp" : "2017-12-03T22:35:59Z",
            "briefDesignDescription" : "High sensitivity troponin for acute chest pain",
            "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109714017264",
            "pageid" : 2343,
            "pdfurl" : null,
            "trainingLevel" : "Intern",
            "citation" : "Bandstein N, <i>et al</i>. \"Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction\". <i>Journal of the American College of Cardiology</i>. 2014. 63(23):2569-2578.",
            "subspecialties" : "Emergency Medicine;Cardiology",
            "expansion" : null,
            "statusUsableDate" : "2015-03-01",
            "briefResultsDescription" : "HS troponin-T is associated with high NPV for MI at 30 days",
            "published" : "2014-06-17",
            "pageName" : "HS troponin-T to rule out MI",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : null,
            "title" : "Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction",
            "pmid" : "24694529"
        },
        {
            "timestamp" : "2017-12-03T22:36:04Z",
            "briefDesignDescription" : "Perinatal vitamins to prevent neural tube defects",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199212243272602",
            "pageid" : 2142,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199212243272602",
            "trainingLevel" : "Student",
            "citation" : "Czeizel AE and Dudas I. \"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation\". <i>The New England Journal of Medicine</i>. 1992. 327(26):1832-1835.",
            "subspecialties" : "Obstetrics;Preventive Medicine",
            "expansion" : null,
            "statusUsableDate" : "2014-09-01",
            "briefResultsDescription" : "Perinatal vitamins reduce neural tube defects",
            "published" : "1992-12-24",
            "pageName" : "Hungarian Prenatal Vitamin Trial",
            "diseases" : "Neural Tube Defects",
            "abbreviation" : null,
            "title" : "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation",
            "pmid" : "1307234"
        },
        {
             "timestamp" : "2018-08-14T17:41:27Z",
             "briefDesignDescription" : "Hydrocortisone, Vit C, and thiamine in sepsis",
             "fulltexturl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext",
             "pageid" : 2946,
             "pdfurl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/pdf",
             "pdfurl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
Line 1,309: Line 3,243:
             "subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
             "subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2018-08-13",
             "briefResultsDescription" : "Pilot study with impressive findings, low-quality data",
             "briefResultsDescription" : "Pilot study with impressive findings, low-quality data",
             "published" : "2017-06-01",
             "published" : "2017-06-01",
Line 1,327: Line 3,262:
             "subspecialties" : "Critical Care",
             "subspecialties" : "Critical Care",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2016-11-01",
             "briefResultsDescription" : "Hydrocortisone not superior to placebo in severe sepsis",
             "briefResultsDescription" : "Hydrocortisone not superior to placebo in severe sepsis",
             "published" : "2016-10-03",
             "published" : "2016-10-03",
Line 1,345: Line 3,281:
             "subspecialties" : "Nephrology;Cardiology;Geriatrics",
             "subspecialties" : "Nephrology;Cardiology;Geriatrics",
             "expansion" : "Hypertension in the Very Elderly Trial",
             "expansion" : "Hypertension in the Very Elderly Trial",
            "statusUsableDate" : "2015-04-01",
             "briefResultsDescription" : "Trend towards reduction in stroke with treatment (P",
             "briefResultsDescription" : "Trend towards reduction in stroke with treatment (P",
             "published" : "2008-05-01",
             "published" : "2008-05-01",
Line 1,363: Line 3,300:
             "subspecialties" : "Cardiology;Critical Care",
             "subspecialties" : "Cardiology;Critical Care",
             "expansion" : "Intraaortic Balloon Pump in Cardiogenic Shock II",
             "expansion" : "Intraaortic Balloon Pump in Cardiogenic Shock II",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "IABP did not reduce mortality at 30 days",
             "briefResultsDescription" : "IABP did not reduce mortality at 30 days",
             "published" : "2012-10-10",
             "published" : "2012-10-10",
Line 1,381: Line 3,319:
             "subspecialties" : "Hematology",
             "subspecialties" : "Hematology",
             "expansion" : null,
             "expansion" : null,
            "statusUsableDate" : "2015-12-01",
             "briefResultsDescription" : "Ibrutinib is safe and effective in previously treated WM",
             "briefResultsDescription" : "Ibrutinib is safe and effective in previously treated WM",
             "published" : "2015-04-09",
             "published" : "2015-04-09",
Line 1,390: Line 3,329:
         },
         },
         {
         {
             "timestamp" : "2017-12-14T19:46:19Z",
             "timestamp" : "2018-10-16T05:02:38Z",
             "briefDesignDescription" : "Ezetimibe+simvastatin after ACS",
             "briefDesignDescription" : "Colchicine in the first episode of acute pericarditis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1410489",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208536",
             "pageid" : 2369,
             "pageid" : 1729,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208536",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Cannon CP, <i>et al</i>. \"Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2015. 375(25):2387-2397.",
             "citation" : "Imazio M, <i>et al</i>. \"A Randomized Trial of Colchicine for Acute Pericarditis\". <i>The New England Journal of Medicine</i>. 2013. 369(16):1522-1528.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "IMProved Reduction of Outcomes: Vytorin Efficacy International Trial",
             "expansion" : "Evaluation of additive benefit of colchicine to conventional therapy in acute pericarditis",
             "briefResultsDescription" : "Ezetimibe improves CV outcomes when added to statin",
            "statusUsableDate" : "2014-01-01",
             "published" : "2015-06-18",
             "briefResultsDescription" : "Colchicine reduces incessant or recurrent acute pericarditis when used in first episode",
             "pageName" : "IMPROVE-IT",
             "published" : "2013-10-17",
             "diseases" : "Hyperlipidemia;Acute Coronary Syndrome;Myocardial Infarction",
             "pageName" : "ICAP",
             "abbreviation" : "IMPROVE-IT",
             "diseases" : "Pericarditis",
             "title" : "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes",
             "abbreviation" : "ICAP",
             "pmid" : "26039521"
             "title" : "A Randomized Trial of Colchicine for Acute Pericarditis",
             "pmid" : "23992557"
         },
         },
         {
         {
             "timestamp" : "2018-03-30T14:11:39Z",
            "timestamp" : "2017-12-03T22:36:07Z",
            "briefDesignDescription" : "Early vs. late dialysis in CKD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000552",
            "pageid" : 1020,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000552",
            "trainingLevel" : "Resident",
            "citation" : "Cooper BA, <i>et al</i>. \"A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis\". <i>The New England Journal of Medicine</i>. 2010. 363(7):609-619.",
            "subspecialties" : "Nephrology",
            "expansion" : "Initiating Dialysis Early and Late",
            "statusUsableDate" : "2012-10-01",
            "briefResultsDescription" : "No difference in survival or clinical outcomes",
            "published" : "2010-08-12",
            "pageName" : "IDEAL",
            "diseases" : "Chronic Kidney Disease",
            "abbreviation" : "IDEAL",
            "title" : "A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis",
            "pmid" : "20581422"
        },
        {
            "timestamp" : "2017-12-03T22:36:08Z",
            "briefDesignDescription" : "ARBs in diabetic nephropathy",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011303",
            "pageid" : 2670,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011303",
            "trainingLevel" : "Resident",
            "citation" : "Lewis EJ, <i>et al</i>. \"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2001. 345(12):851-860.",
            "subspecialties" : "Nephrology;Endocrinology",
            "expansion" : "Irbesartan Diabetic Nephropathy Trial",
            "statusUsableDate" : "2016-01-01",
            "briefResultsDescription" : "ARBs prevent progression of T2DM nephropathy",
            "published" : "2001-09-20",
            "pageName" : "IDNT",
            "diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
            "abbreviation" : "IDNT",
            "title" : "Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes",
            "pmid" : "11565517"
        },
        {
            "timestamp" : "2017-12-03T22:36:10Z",
            "briefDesignDescription" : "iFR vs. FFR for PCI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1616540",
            "pageid" : 2926,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1616540",
            "trainingLevel" : "Resident",
            "citation" : "Gotberg M, <i>et al</i>. \"Spontaneous wave-free ratio versus fractional flow reserve to guide PCI\". <i>The New England Journal of Medicine</i>. 2017. 376(19):1813-1823.",
            "subspecialties" : "Cardiology",
            "expansion" : "Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome",
            "statusUsableDate" : "2017-05-01",
            "briefResultsDescription" : "iFR noninferior to FFR for PCI",
            "published" : "2017-05-11",
            "pageName" : "IFR-SWEDEHEART",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "iFR-SWEDEHEART",
            "title" : "Spontaneous wave-free ratio versus fractional flow reserve to guide PCI",
            "pmid" : "28317438"
        },
        {
            "timestamp" : "2017-12-14T19:46:19Z",
            "briefDesignDescription" : "Ezetimibe+simvastatin after ACS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1410489",
            "pageid" : 2369,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489",
            "trainingLevel" : "Intern",
            "citation" : "Cannon CP, <i>et al</i>. \"Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2015. 375(25):2387-2397.",
            "subspecialties" : "Cardiology",
            "expansion" : "IMProved Reduction of Outcomes: Vytorin Efficacy International Trial",
            "statusUsableDate" : "2015-06-01",
            "briefResultsDescription" : "Ezetimibe improves CV outcomes when added to statin",
            "published" : "2015-06-18",
            "pageName" : "IMPROVE-IT",
            "diseases" : "Hyperlipidemia;Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : "IMPROVE-IT",
            "title" : "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes",
            "pmid" : "26039521"
        },
        {
             "timestamp" : "2018-03-30T14:11:39Z",
             "briefDesignDescription" : "Nintedanib in IPF",
             "briefDesignDescription" : "Nintedanib in IPF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402584",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402584",
Line 1,417: Line 3,433:
             "subspecialties" : "Pulmonology",
             "subspecialties" : "Pulmonology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2018-03-30",
             "briefResultsDescription" : "Nintedanib slows progression of IPF",
             "briefResultsDescription" : "Nintedanib slows progression of IPF",
             "published" : "2014-05-29",
             "published" : "2014-05-29",
Line 1,426: Line 3,443:
         },
         },
         {
         {
             "timestamp" : "2017-12-20T19:04:02Z",
            "timestamp" : "2017-12-03T22:36:12Z",
             "briefDesignDescription" : "Aspirin ± streptokinase in acute MI",
            "briefDesignDescription" : "Early vs. delayed ART in HIV",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(88)92833-4/abstract",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506816",
            "pageid" : 2468,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506816",
            "trainingLevel" : "Student",
            "citation" : "INSIGHT START Writers. \"Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection\". <i>The New England Journal of Medicine</i>. 2015. 373(9):795-807.",
            "subspecialties" : "Infectious Disease",
            "expansion" : null,
            "statusUsableDate" : "2016-01-01",
            "briefResultsDescription" : "Less complications with early ART",
            "published" : "2015-08-27",
            "pageName" : "INSIGHT START",
            "diseases" : "HIV",
            "abbreviation" : "START",
            "title" : "Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection",
            "pmid" : "26192873"
        },
        {
            "timestamp" : "2017-12-03T22:36:14Z",
            "briefDesignDescription" : "ART in primary HIV prevention",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011205",
            "pageid" : 1100,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011205",
            "trainingLevel" : "intern",
            "citation" : "Grant RM, <i>et al</i>. \"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men\". <i>The New England Journal of Medicine</i>. 2010. 363(27):2587-2599.",
            "subspecialties" : "Infectious Disease;Preventive Medicine",
            "expansion" : "Iniciativa Profilaxis Pre Exposicion (\"Preexposure Prophylaxis Initiative\")",
            "statusUsableDate" : "2013-02-01",
            "briefResultsDescription" : "ART reduces tranmission of HIV among MSM",
            "published" : "2010-12-30",
            "pageName" : "IPrEx",
            "diseases" : "HIV",
            "abbreviation" : "iPrEx",
            "title" : "Preexposure chemoprophylaxis for HIV prevention in men who have sex with men",
            "pmid" : "21091279"
        },
        {
            "timestamp" : "2017-12-03T22:36:15Z",
            "briefDesignDescription" : "Imatinib vs. IFNα/cytarabine in CML",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa022457",
            "pageid" : 1076,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa022457",
            "trainingLevel" : "Student",
            "citation" : "O'Brien SG, <i>et al</i>. \"Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia\". <i>The New England Journal of Medicine</i>. 2003. 384(11):994-1004.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "International Randomized Study of Interferon and STI571",
            "statusUsableDate" : "2012-11-01",
            "briefResultsDescription" : "Imatinib delays disease progression",
            "published" : "2003-03-13",
            "pageName" : "IRIS",
            "diseases" : "Chronic Myeloid Leukemia;Myeloproliferative Neoplasms",
            "abbreviation" : "IRIS",
            "title" : "Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia",
            "pmid" : "12637609"
        },
        {
            "timestamp" : "2017-12-03T22:36:17Z",
            "briefDesignDescription" : "Oral iron vs. placebo in HFrEF and iron deficiency",
            "fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
            "pageid" : 2941,
            "pdfurl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
            "trainingLevel" : "Resident",
            "citation" : "Lewis GD, <i>et al</i>. \"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency\". <i>JAMA</i>. 2017. 317(19):1958-66.",
            "subspecialties" : "Cardiology",
            "expansion" : "Iron Repletion Effects on Oxygen Uptake in Heart Failure",
            "statusUsableDate" : "2017-07-01",
            "briefResultsDescription" : "Oral iron not superior to placebo in HFrEF",
            "published" : "2017-07-09",
            "pageName" : "IRONOUT-HF",
            "diseases" : "Heart Failure",
            "abbreviation" : "IRONOUT-HF",
            "title" : "Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency",
            "pmid" : "28510680"
        },
        {
            "timestamp" : "2017-12-03T22:36:18Z",
            "briefDesignDescription" : "Triple therapy for 6w vs. 6m after DES",
            "fulltexturl" : "http://content.onlinejacc.org/article.aspx?articleID",
            "pageid" : 2812,
            "pdfurl" : "http://content.onlinejacc.org/data/Journals/JAC/933764/02050.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Fiedler KA <i>et al</i>. \"Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation\". <i>J Am Coll Cardiol</i>. 2015. 65(16):1619-30.",
            "subspecialties" : "Cardiology",
            "expansion" : "Triple therapy in Patients who Require Oral Anticoagulation After Drug-Eluting Stent Implantation",
            "statusUsableDate" : "2016-10-01",
            "briefResultsDescription" : "Triple therapy for 6 weeks not superior to 6 months in regards to net clinical outcome",
            "published" : "2015-04-28",
            "pageName" : "ISAR-TRIPLE",
            "diseases" : "Coronary Artery Disease;Atrial Fibrillation",
            "abbreviation" : "ISAR-TRIPLE",
            "title" : "Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation",
            "pmid" : "25908066"
        },
        {
             "timestamp" : "2017-12-20T19:04:02Z",
             "briefDesignDescription" : "Aspirin ± streptokinase in acute MI",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(88)92833-4/abstract",
             "pageid" : 133,
             "pageid" : 133,
             "pdfurl" : "",
             "pdfurl" : "",
Line 1,435: Line 3,547:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Second International Study of Infarct Survival",
             "expansion" : "Second International Study of Infarct Survival",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Mortality benefit of aspirin within 24 hours of acute MI",
             "briefResultsDescription" : "Mortality benefit of aspirin within 24 hours of acute MI",
             "published" : "1988-08-13",
             "published" : "1988-08-13",
Line 1,453: Line 3,566:
             "subspecialties" : "Neurology",
             "subspecialties" : "Neurology",
             "expansion" : "International Stroke Trial",
             "expansion" : "International Stroke Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Mortality benefit with aspirin",
             "briefResultsDescription" : "Mortality benefit with aspirin",
             "published" : "1997-05-31",
             "published" : "1997-05-31",
Line 1,460: Line 3,574:
             "title" : "The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke",
             "title" : "The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke",
             "pmid" : "9174558"
             "pmid" : "9174558"
        },
        {
            "timestamp" : "2017-12-03T22:36:21Z",
            "briefDesignDescription" : "Rosuvastatin for primary CV prevention",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807646",
            "pageid" : 445,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807646",
            "trainingLevel" : "resident",
            "citation" : "Ridker PM, <i>et al</i>. \"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein\". <i>The New England Journal of Medicine</i>. 2008. 359(21):2195-2207.",
            "subspecialties" : "Cardiology;Preventive Medicine",
            "expansion" : "Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin",
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "Rosuvastatin delays major CV events",
            "published" : "2008-11-20",
            "pageName" : "JUPITER",
            "diseases" : "Hyperlipidemia;Coronary Artery Disease;Stroke;Transient Ischemic Attack",
            "abbreviation" : "JUPITER",
            "title" : "Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein",
            "pmid" : "18997196"
        },
        {
            "timestamp" : "2017-12-03T22:36:23Z",
            "briefDesignDescription" : "Pembrolizumab vs. chemotherapy in NSCLC",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1606774",
            "pageid" : 2846,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1606774",
            "trainingLevel" : "Resident",
            "citation" : "Reck M, <i>et al</i>. \"Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer\". <i>The New England Journal of Medicine</i>. 2016. 375(19):1824-1833.",
            "subspecialties" : "Oncology",
            "expansion" : "",
            "statusUsableDate" : "2016-11-01",
            "briefResultsDescription" : "Pembrolizumab improves survival in advanced NSCLC over chemotherapy",
            "published" : "2016-11-10",
            "pageName" : "KEYNOTE-024",
            "diseases" : "Lung Cancer",
            "abbreviation" : "KEYNOTE-024",
            "title" : "Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer",
            "pmid" : "27718847"
         },
         },
         {
         {
Line 1,471: Line 3,623:
             "subspecialties" : "Cardiology;Endocrinology",
             "subspecialties" : "Cardiology;Endocrinology",
             "expansion" : "Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results",
             "expansion" : "Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results",
            "statusUsableDate" : "2016-09-01",
             "briefResultsDescription" : "Liraglutide reduces CV mortality in T2DM",
             "briefResultsDescription" : "Liraglutide reduces CV mortality in T2DM",
             "published" : "2016-06-28",
             "published" : "2016-06-28",
Line 1,489: Line 3,642:
             "subspecialties" : "Hematology;Oncology",
             "subspecialties" : "Hematology;Oncology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2018-10-25",
             "briefResultsDescription" : "In flawed trial, LenDex improved OS compared to observation",
             "briefResultsDescription" : "In flawed trial, LenDex improved OS compared to observation",
             "published" : "2013-08-01",
             "published" : "2013-08-01",
Line 1,496: Line 3,650:
             "title" : "Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma",
             "title" : "Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma",
             "pmid" : "23902483"
             "pmid" : "23902483"
        },
        {
            "timestamp" : "2017-12-03T22:36:26Z",
            "briefDesignDescription" : "Epidural steroids in spinal stenosis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313265",
            "pageid" : 1883,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313265",
            "trainingLevel" : "Resident",
            "citation" : "Friedly JL, <i>et al</i>. \"A randomized trial of epidural glucocorticoid injections for spinal stenosis\". <i>The New England Journal of Medicine</i>. 2014. 371(1):11-21.",
            "subspecialties" : "Pain Medicine;Physical Medicine and Rehabilitation;Radiology",
            "expansion" : "Lumbar Epidural Steroid Injections for Spinal Stenosis",
            "statusUsableDate" : "2014-07-01",
            "briefResultsDescription" : "Epidural steroids don't improve pain or disability at six weeks",
            "published" : "2014-07-03",
            "pageName" : "LESS",
            "diseases" : "Spinal Stenosis",
            "abbreviation" : "LESS",
            "title" : "A randomized trial of epidural glucocorticoid injections for spinal stenosis",
            "pmid" : "24988555"
         },
         },
         {
         {
Line 1,507: Line 3,680:
             "subspecialties" : "Critical Care;Endocrinology",
             "subspecialties" : "Critical Care;Endocrinology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Intensive glycemic control reduces mortality",
             "briefResultsDescription" : "Intensive glycemic control reduces mortality",
             "published" : "2001-11-08",
             "published" : "2001-11-08",
Line 1,516: Line 3,690:
         },
         },
         {
         {
             "timestamp" : "2015-08-24T04:47:14Z",
            "timestamp" : "2017-12-03T22:36:27Z",
             "briefDesignDescription" : "ICD in post-MI patients with HFrEF",
            "briefDesignDescription" : "ATRA-ATO vs. ATRA-chemotherapy in APL",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300874",
            "pageid" : 2285,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300874",
            "trainingLevel" : "Fellow",
            "citation" : "Lo-Coco F, <i>et al</i>. \"Retinoic acid and arsenic trioxide for acute promyelocytic leukemia\". <i>The New England Journal of Medicine</i>. 2013. 369(2):111-21.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "",
            "statusUsableDate" : "2014-12-01",
            "briefResultsDescription" : "ATRA-ATO is noninferior, possibly superior to ATRA-chemotherapy in APL",
            "published" : "2013-07-11",
            "pageName" : "Lo-Coco 2013",
            "diseases" : "Leukemia",
            "abbreviation" : "",
            "title" : "Retinoic acid and arsenic trioxide for acute promyelocytic leukemia",
            "pmid" : "23841729"
        },
        {
            "timestamp" : "2017-12-03T22:37:20Z",
            "briefDesignDescription" : "Colchicine for stable CAD",
            "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109712054782",
            "pageid" : 1583,
            "pdfurl" : null,
            "trainingLevel" : "Resident",
            "citation" : "Nidorf SM, <i>et al</i>. \"Low-dose colchicine for secondary prevention of cardiovascular disease\". <i>Journal of the American College of Cardiology</i>. 2013. 61(4):404-410.",
            "subspecialties" : "Cardiology",
            "expansion" : "Low-Dose Colchicine",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "Colcicine may reduce complications in stable CAD",
            "published" : "2013-01-29",
            "pageName" : "LoDoCo",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "LoDoCo",
            "title" : "Low-dose colchicine for secondary prevention of cardiovascular disease",
            "pmid" : "23265346"
        },
        {
            "timestamp" : "2017-12-03T22:37:21Z",
            "briefDesignDescription" : "Weight loss and exercise in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212914",
            "pageid" : 1546,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212914",
            "trainingLevel" : "Intern",
            "citation" : "Wing RR, <i>et al</i>. \"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2013. 369(2):145-154.",
            "subspecialties" : "Endocrinology;Cardiology",
            "expansion" : "Look Action for HEAlth in Diabetes",
            "statusUsableDate" : "2013-09-01",
            "briefResultsDescription" : "No reduction of CVD with weight loss and exercise in T2DM",
            "published" : "2013-07-11",
            "pageName" : "Look AHEAD",
            "diseases" : "Diabetes Mellitus;Cardiovascular Disease",
            "abbreviation" : "Look AHEAD",
            "title" : "Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes",
            "pmid" : "23796131"
        },
        {
            "timestamp" : "2017-12-03T22:37:23Z",
            "briefDesignDescription" : "CRT in HFrEF with QRS ≥130 msec and mild symptoms",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906431",
            "pageid" : 1780,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906431",
            "trainingLevel" : "Resident",
            "citation" : "Moss AJ, <i>et al</i>. \"Cardiac-resynchronization therapy for the prevention of heart-failure events\". <i>The New England Journal of Medicine</i>. 2009. 361(14):1329-1338.",
            "subspecialties" : "Cardiology",
            "expansion" : "Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy",
            "statusUsableDate" : "2014-04-01",
            "briefResultsDescription" : "CRT reduces mortality or HF complications in mildly symptomatic HFrEF with prolonged QRS",
            "published" : "2009-10-01",
            "pageName" : "MADIT-CRT",
            "diseases" : "Heart Failure",
            "abbreviation" : "MADIT-CRT",
            "title" : "Cardiac-resynchronization therapy for the prevention of heart-failure events",
            "pmid" : "19723701"
        },
        {
             "timestamp" : "2015-08-24T04:47:14Z",
             "briefDesignDescription" : "ICD in post-MI patients with HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013474",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013474",
             "pageid" : 385,
             "pageid" : 385,
Line 1,525: Line 3,775:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Multicenter Automatic Defibrillator Implantation Trial II",
             "expansion" : "Multicenter Automatic Defibrillator Implantation Trial II",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "ICD improves survival in post-MI patients with LVEF≤30%",
             "briefResultsDescription" : "ICD improves survival in post-MI patients with LVEF≤30%",
             "published" : "2002-03-21",
             "published" : "2002-03-21",
Line 1,532: Line 3,783:
             "title" : "Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction",
             "title" : "Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction",
             "pmid" : "11907286"
             "pmid" : "11907286"
        },
        {
            "timestamp" : "2017-12-03T22:37:25Z",
            "briefDesignDescription" : "Rivaroxaban vs. LMWH for VTE prophylaxis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1111096",
            "pageid" : 1272,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1111096",
            "trainingLevel" : "Resident",
            "citation" : "Cohen AT, <i>et al</i>. \"Rivaroxaban for thromboprophylaxis in acutely ill medical patients\". <i>The New England Journal of Medicine</i>. 2013. 368(6):513-523.",
            "subspecialties" : "Hematology",
            "expansion" : "Multicenter, Randomized, Parallel Group Efficacy and Safety Study for the Prevention of Venous Thromboembolism in Hospitalized Acutely Ill Medical Patients Comparing Rivaroxaban with Enoxaparin",
            "statusUsableDate" : "2013-10-01",
            "briefResultsDescription" : "Rivaroxaban similar to LMWH for prophylaxis, caused more bleeding",
            "published" : "2013-02-07",
            "pageName" : "MAGELLAN",
            "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
            "abbreviation" : "MAGELLAN",
            "title" : "Rivaroxaban for thromboprophylaxis in acutely ill medical patients",
            "pmid" : "23388003"
         },
         },
         {
         {
Line 1,543: Line 3,813:
             "subspecialties" : "Hematology;Cardiology",
             "subspecialties" : "Hematology;Cardiology",
             "expansion" : "Medically Ill Patient Assessment of Rivaroxaban versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk",
             "expansion" : "Medically Ill Patient Assessment of Rivaroxaban versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk",
            "statusUsableDate" : "2018-09-13",
             "briefResultsDescription" : "Rivaroxaban does not prevent VTE in medically ill patients",
             "briefResultsDescription" : "Rivaroxaban does not prevent VTE in medically ill patients",
             "published" : "2017-08-27",
             "published" : "2017-08-27",
Line 1,550: Line 3,821:
             "title" : "Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness",
             "title" : "Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness",
             "pmid" : "30145946"
             "pmid" : "30145946"
        },
        {
            "timestamp" : "2017-12-03T22:37:27Z",
            "briefDesignDescription" : "US screening for AAA in men",
            "fulltexturl" : "http://www.bmj.com/content/338/bmj.b2307.long",
            "pageid" : 2397,
            "pdfurl" : "http://www.bmj.com/content/338/bmj.b2307.full.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Thompson SG, <i>et al</i>. \"Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study\". <i>BMJ</i>. 2009. 338:b2307.",
            "subspecialties" : "Preventive Medicine;Radiology",
            "expansion" : "Multicentre Aneurysm Screening Study",
            "statusUsableDate" : "2015-10-01",
            "briefResultsDescription" : "US screening reduces AAA mortality in men",
            "published" : "2009-06-24",
            "pageName" : "MASS",
            "diseases" : "Abdominal Aortic Aneurysm",
            "abbreviation" : "MASS",
            "title" : "Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study",
            "pmid" : "19553269"
        },
        {
            "timestamp" : "2017-12-03T22:37:28Z",
            "briefDesignDescription" : "ASA/clopidogrel vs. clopidogrel in stroke",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)16721-4/fulltext",
            "pageid" : 1125,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673604167214.pdf",
            "trainingLevel" : "student",
            "citation" : "Diener HC, <i>et al</i>. \"Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial\". <i>The Lancet</i>. 2004. 364(9431):331-337.",
            "subspecialties" : "Neurology",
            "expansion" : "Management of Atherothrombosis with Clopidogrel in High-risk patients",
            "statusUsableDate" : "2013-04-01",
            "briefResultsDescription" : "More major bleeding but no greater efficacy with combination therapy",
            "published" : "2004-07-24",
            "pageName" : "MATCH",
            "diseases" : "Stroke",
            "abbreviation" : "MATCH",
            "title" : "Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial",
            "pmid" : "15276392"
         },
         },
         {
         {
Line 1,561: Line 3,870:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure",
             "expansion" : "Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Metoprolol improves survival in NYHA II-IV HFrEF",
             "briefResultsDescription" : "Metoprolol improves survival in NYHA II-IV HFrEF",
             "published" : "1999-06-12",
             "published" : "1999-06-12",
Line 1,570: Line 3,880:
         },
         },
         {
         {
             "timestamp" : "2015-06-21T20:25:46Z",
            "timestamp" : "2017-12-03T22:37:29Z",
            "briefDesignDescription" : "Surgery vs. PT in OA with meniscal tear",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1301408",
            "pageid" : 1429,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1301408",
            "trainingLevel" : "Student",
            "citation" : "Katz JN, <i>et al</i>. \"Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis\". <i>The New England Journal of Medicine</i>. 2013. 368(18):1675-1684.",
            "subspecialties" : "Surgery;Physical Medicine and Rehabilitation",
            "expansion" : "Meniscal Tear in Osteoarthritis Research",
            "statusUsableDate" : "2013-09-01",
            "briefResultsDescription" : "Surgery no better than PT alone",
            "published" : "2013-05-02",
            "pageName" : "METEOR",
            "diseases" : "Meniscal Tear;Osteoarthritis",
            "abbreviation" : "METEOR",
            "title" : "Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis",
            "pmid" : "23506518"
        },
        {
            "timestamp" : "2017-12-03T22:37:31Z",
            "briefDesignDescription" : "Early surgery for MR",
            "fulltexturl" : "",
            "pageid" : 1787,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/927436/joi130034.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Suri RM, <i>et al</i>. \"Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets\". <i>JAMA</i>. 2013. 310(6):609-616.",
            "subspecialties" : "Cardiology",
            "expansion" : "Mitral Regurgitation International Database",
            "statusUsableDate" : "2014-02-01",
            "briefResultsDescription" : "Early surgery reduces mortality in MR",
            "published" : "2013-08-14",
            "pageName" : "MIDA",
            "diseases" : "Mitral Regurgitation",
            "abbreviation" : "MIDA",
            "title" : "Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets",
            "pmid" : "23942679"
        },
        {
             "timestamp" : "2015-06-21T20:25:46Z",
             "briefDesignDescription" : "Atorvastatin in UA/NSTEMI",
             "briefDesignDescription" : "Atorvastatin in UA/NSTEMI",
             "fulltexturl" : "http://jama.ama-assn.org/content/285/13/1711.long",
             "fulltexturl" : "http://jama.ama-assn.org/content/285/13/1711.long",
Line 1,579: Line 3,927:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering",
             "expansion" : "Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Atorvastatin reduced rate of CV events after UA/NSTEMI",
             "briefResultsDescription" : "Atorvastatin reduced rate of CV events after UA/NSTEMI",
             "published" : "2001-04-04",
             "published" : "2001-04-04",
Line 1,597: Line 3,946:
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2017-05-01",
             "briefResultsDescription" : "Bezlotoxumab reduces the rate of recurrent Clostridium difficile Infection",
             "briefResultsDescription" : "Bezlotoxumab reduces the rate of recurrent Clostridium difficile Infection",
             "published" : "2017-01-26",
             "published" : "2017-01-26",
Line 1,615: Line 3,965:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3",
             "expansion" : "Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3",
            "statusUsableDate" : "2018-06-29",
             "briefResultsDescription" : "Centrifugal-flow LVAD superior to axial-flow LVAD in advanced HF",
             "briefResultsDescription" : "Centrifugal-flow LVAD superior to axial-flow LVAD in advanced HF",
             "published" : "2018-04-12",
             "published" : "2018-04-12",
Line 1,622: Line 3,973:
             "title" : "Two-year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure",
             "title" : "Two-year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure",
             "pmid" : "29526139"
             "pmid" : "29526139"
        },
        {
            "timestamp" : "2017-12-03T22:37:34Z",
            "briefDesignDescription" : "Low-dose tPA for submassive PE",
            "fulltexturl" : "http://www.ajconline.org/article/S0002-9149%2812%2902205-9/fulltext",
            "pageid" : 1785,
            "pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0002-9149/PIIS0002914912022059.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Sharifi M, <i>et al</i>. \"Moderate pulmonary embolism treated with thrombolysis\". <i>The American Journal of Cardiology</i>. 2013. 111(2):273-277.",
            "subspecialties" : "Critical Care;Pulmonology;Cardiology",
            "expansion" : "Moderate Pulmonary Embolism Treated with Thrombolysis",
            "statusUsableDate" : "2014-02-01",
            "briefResultsDescription" : "Low-dose tPA reduces pulmonary HTN in submassive PE",
            "published" : "2013-01-15",
            "pageName" : "MOPETT",
            "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
            "abbreviation" : "MOPETT",
            "title" : "Moderate pulmonary embolism treated with thrombolysis",
            "pmid" : "23102885"
        },
        {
            "timestamp" : "2017-12-03T22:37:42Z",
            "briefDesignDescription" : "Arthroscopy in knee OA",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa013259",
            "pageid" : 1055,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa013259",
            "trainingLevel" : "Resident",
            "citation" : "Moseley JB, <i>et al</i>. \"A controlled trial of arthroscopic surgery for osteoarthritis of the knee\". <i>The New England Journal of Medicine</i>. 2002. 347(2):81-88.",
            "subspecialties" : "Surgery;Physical Medicine and Rehabilitation",
            "expansion" : "",
            "statusUsableDate" : "2012-11-01",
            "briefResultsDescription" : "No difference between groups at 2 years",
            "published" : "2002-07-11",
            "pageName" : "Moseley Trial",
            "diseases" : "Osteoarthritis",
            "abbreviation" : "",
            "title" : "A controlled trial of arthroscopic surgery for osteoarthritis of the knee",
            "pmid" : "12110735"
        },
        {
            "timestamp" : "2017-12-03T22:37:36Z",
            "briefDesignDescription" : "Gemcitabine/nab-paclitaxel in pancreatic cancer",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1304369",
            "pageid" : 2816,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1304369",
            "trainingLevel" : "Resident",
            "citation" : "Von Hoff DD, <i>et al</i>. \"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine\". <i>The New England Journal of Medicine</i>. 2013. 369(18):1691-1703.",
            "subspecialties" : "Oncology",
            "expansion" : "Metastatic Pancreatic Adenocarcinoma Clinical Trial",
            "statusUsableDate" : "2016-08-01",
            "briefResultsDescription" : "Gemcicabine/nab-paclitaxel improves OS in metastatic pancreatic cancer compared to gemcitabine",
            "published" : "2013-10-31",
            "pageName" : "MPACT",
            "diseases" : "Pancreatic Cancer",
            "abbreviation" : "MPACT",
            "title" : "Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine",
            "pmid" : "24131140"
         },
         },
         {
         {
Line 1,633: Line 4,041:
             "subspecialties" : "Neurology",
             "subspecialties" : "Neurology",
             "expansion" : "",
             "expansion" : "",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "IA therapy improves outcome without increased mortality or ICH",
             "briefResultsDescription" : "IA therapy improves outcome without increased mortality or ICH",
             "published" : "2015-01-01",
             "published" : "2015-01-01",
Line 1,640: Line 4,049:
             "title" : "A randomized trial of intraarterial treatment for acute ischemic stroke",
             "title" : "A randomized trial of intraarterial treatment for acute ischemic stroke",
             "pmid" : "25517348"
             "pmid" : "25517348"
        },
        {
            "timestamp" : "2017-12-03T22:37:37Z",
            "briefDesignDescription" : "Thrombectomy vs. standard care in stroke",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212793",
            "pageid" : 2363,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212793",
            "trainingLevel" : "Fellow",
            "citation" : "Kidwell CS, <i>et al</i>. \"A trial of imaging selection and endovascular treatment for ischemic stroke\". <i>The New England Journal of Medicine</i>. 2013. 368(10):914-923.",
            "subspecialties" : "Neurology",
            "expansion" : "",
            "statusUsableDate" : "2015-05-01",
            "briefResultsDescription" : "Imaging did not id pts who would benefit from endovascular thrombectomy for acute ischemic stroke.",
            "published" : "2013-03-07",
            "pageName" : "MR RESCUE",
            "diseases" : "Stroke",
            "abbreviation" : "MR RESCUE",
            "title" : "A trial of imaging selection and endovascular treatment for ischemic stroke",
            "pmid" : "23394476"
        },
        {
            "timestamp" : "2017-12-03T22:37:39Z",
            "briefDesignDescription" : "Hydroxyurea in sickle-cell disease",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199505183322001",
            "pageid" : 2797,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199505183322001",
            "trainingLevel" : "Student",
            "citation" : "Charache S, <i>et al</i>. \"Effect of hydroxyurea on the frequency of painful crises in sickle-cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle-Cell Anemia\". <i>The New England Journal of Medicine</i>. 1995. 332(20):1317-1322.",
            "subspecialties" : "Hematology",
            "expansion" : "Multicenter Study of Hydroxyurea in Sickle-Cell Anemia",
            "statusUsableDate" : "2016-07-01",
            "briefResultsDescription" : "Hydroxyurea ↓frequency of painful crises in SCD",
            "published" : "1995-05-18",
            "pageName" : "MSH",
            "diseases" : "Sickle-Cell Disease",
            "abbreviation" : "MSH",
            "title" : "Effect of hydroxyurea on the frequency of painful crises in sickle-cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle-Cell Anemia",
            "pmid" : "7715639"
        },
        {
            "timestamp" : "2017-12-03T22:37:40Z",
            "briefDesignDescription" : "ICD vs. antiarrhythmics vs. neither in mild HF and VT at EPS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199912163412503",
            "pageid" : 2872,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199912163412503",
            "trainingLevel" : "Resident",
            "citation" : "Buxton AE <i>et al</i>. \"A randomized study of the prevention of sudden death in patients with coronary artery disease\". <i>New Engl J Med</i>. 1999. 341(25):1882-90.",
            "subspecialties" : "Cardiology",
            "expansion" : "Multicenter Unsustained Tachycardia Trial",
            "statusUsableDate" : "2016-12-01",
            "briefResultsDescription" : "EPS guided ICD placement in patients with mild LV systolic dysfunction superior to antiarrhythmic therapy or no treatment",
            "published" : "1999-12-16",
            "pageName" : "MUSTT",
            "diseases" : "Ventricular Tachycardia",
            "abbreviation" : "MUSTT",
            "title" : "A randomized study of the prevention of sudden death in patients with coronary artery disease",
            "pmid" : "10601507"
        },
        {
            "timestamp" : "2017-12-03T22:37:44Z",
            "briefDesignDescription" : "Early vs. delayed ART in HIV",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807252",
            "pageid" : 1039,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807252",
            "trainingLevel" : "Resident",
            "citation" : "Kitahata MM, <i>et al</i>. \"Effect of Early vs. Deferred Antiretroviral therapy for HIV on Survival\". <i>The New England Journal of Medicine</i>. 2009. 360(18):1815-1826.",
            "subspecialties" : "Infectious Disease",
            "expansion" : "North American AIDS Cohort Collaboration on Research and Design",
            "statusUsableDate" : "2014-11-01",
            "briefResultsDescription" : "Early ART in HIV improves survival",
            "published" : "2009-04-30",
            "pageName" : "NA-ACCORD",
            "diseases" : "HIV",
            "abbreviation" : "NA-ACCORD",
            "title" : "Effect of Early vs. Deferred Antiretroviral therapy for HIV on Survival",
            "pmid" : "19339714"
         },
         },
         {
         {
Line 1,651: Line 4,136:
             "subspecialties" : "Surgery;Neurology",
             "subspecialties" : "Surgery;Neurology",
             "expansion" : "North American Symptomatic Carotid Endarterectomy Trial",
             "expansion" : "North American Symptomatic Carotid Endarterectomy Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "CEA reduces the risk of death or stroke in symptomatic 50-69% carotid stenosis",
             "briefResultsDescription" : "CEA reduces the risk of death or stroke in symptomatic 50-69% carotid stenosis",
             "published" : "1998-11-12",
             "published" : "1998-11-12",
Line 1,658: Line 4,144:
             "title" : "Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis",
             "title" : "Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis",
             "pmid" : "9811916"
             "pmid" : "9811916"
        },
        {
            "timestamp" : "2017-12-03T22:37:45Z",
            "briefDesignDescription" : "Dialysis prescriptions in ESRD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198111123052003",
            "pageid" : 504,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198111123052003",
            "trainingLevel" : "Fellow",
            "citation" : "Lowrie EG, <i>et al</i>. \"Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study\". <i>The New England Journal of Medicine</i>. 1981. 305(20):1176-1181.",
            "subspecialties" : "Nephrology",
            "expansion" : "The National Cooperative Dialysis Study",
            "statusUsableDate" : "2013-07-01",
            "briefResultsDescription" : "Low BUN better tolerated, fewer hospitalizations",
            "published" : "1981-11-12",
            "pageName" : "NCDS",
            "diseases" : "Chronic Kidney Disease",
            "abbreviation" : "NCDS",
            "title" : "Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study",
            "pmid" : "7027040"
        },
        {
            "timestamp" : "2017-12-03T22:37:47Z",
            "briefDesignDescription" : "Nitrates for activity tolerance in HFpEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1510774",
            "pageid" : 2668,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1510774",
            "trainingLevel" : "Resident",
            "citation" : "Redfield MM, <i>et al</i>. \"Isosorbide mononitrate in heart failure with preserved ejection fraction\". <i>New England Journal of Medicine</i>. 2015. 373(24):2314-2324.",
            "subspecialties" : "Cardiology",
            "expansion" : "Nitrate’s Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction",
            "statusUsableDate" : "2016-04-01",
            "briefResultsDescription" : "Nitrates do not improve activity tolerance in HFpEF",
            "published" : "2015-12-10",
            "pageName" : "NEAT-HFpEF",
            "diseases" : "Heart Failure",
            "abbreviation" : "NEAT-HFpEF",
            "title" : "Isosorbide mononitrate in heart failure with preserved ejection fraction",
            "pmid" : "26549714"
        },
        {
            "timestamp" : "2017-12-03T22:37:49Z",
            "briefDesignDescription" : "Lung volume reduction in COPD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030287",
            "pageid" : 1604,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030287",
            "trainingLevel" : "Resident",
            "citation" : "Fishman A, <i>et al</i>. \"A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema\". <i>The New England Journal of Medicine</i>. 2003. 348(21):2059-2073.",
            "subspecialties" : "Surgery;Pulmonology",
            "expansion" : "National Emphysema Treatment Trial",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "LVRS benefits apical emphysema and those with low exercise function",
            "published" : "2003-05-22",
            "pageName" : "NETT",
            "diseases" : "Chronic Obstructive Pulmonary Disease;Emphysema",
            "abbreviation" : "NETT",
            "title" : "A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema",
            "pmid" : "12759479"
         },
         },
         {
         {
Line 1,669: Line 4,212:
             "subspecialties" : "Critical Care;Endocrinology",
             "subspecialties" : "Critical Care;Endocrinology",
             "expansion" : "Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation",
             "expansion" : "Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Increased mortality targeting euglycemia",
             "briefResultsDescription" : "Increased mortality targeting euglycemia",
             "published" : "2009-03-26",
             "published" : "2009-03-26",
Line 1,687: Line 4,231:
             "subspecialties" : "Neurology;Critical Care",
             "subspecialties" : "Neurology;Critical Care",
             "expansion" : "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study",
             "expansion" : "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "tPA within 3 hours improved outcomes",
             "briefResultsDescription" : "tPA within 3 hours improved outcomes",
             "published" : "1995-12-14",
             "published" : "1995-12-14",
Line 1,694: Line 4,239:
             "title" : "Tissue Plasminogen Activator for Acute Ischemic Stroke",
             "title" : "Tissue Plasminogen Activator for Acute Ischemic Stroke",
             "pmid" : "7477192"
             "pmid" : "7477192"
        },
        {
            "timestamp" : "2017-12-03T22:37:50Z",
            "briefDesignDescription" : "CT vs. CXR in lung cancer screening",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102873",
            "pageid" : 980,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102873",
            "trainingLevel" : "Resident",
            "citation" : "Berg CD, <i>et al</i>. \"Reduced lung cancer mortality with low-dose computed tomographic screening\". <i>The New England Journal of Medicine</i>. 2011. 365(5):395-409.",
            "subspecialties" : "Pulmonology;Oncology;Preventive Medicine",
            "expansion" : "National Lung Screening Trial",
            "statusUsableDate" : "2012-10-01",
            "briefResultsDescription" : "Low-dose CT reduces lung cancer mortality compared to CXR",
            "published" : "2011-08-04",
            "pageName" : "NLST",
            "diseases" : "Lung Cancer",
            "abbreviation" : "NLST",
            "title" : "Reduced lung cancer mortality with low-dose computed tomographic screening",
            "pmid" : "21714641"
        },
        {
            "timestamp" : "2017-12-03T22:37:52Z",
            "briefDesignDescription" : "Drug-eluting stent vs. bare-metal stent in CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1607991",
            "pageid" : 2832,
            "pdfurl" : null,
            "trainingLevel" : "Resident",
            "citation" : "Bonaa KH, <i>et al</i>. \"Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease\". <i>The New England Journal of Medicine</i>. 2016. 375:1242-1252.",
            "subspecialties" : "Cardiology",
            "expansion" : "Drug-Eluting or Bare-Metal Stents for Percutaneous Coronary Intervention in Stable or Unstable Coronary Artery Disease",
            "statusUsableDate" : "2016-10-01",
            "briefResultsDescription" : "Drug-eluting stent superior to bare-metal stent in CAD",
            "published" : "2016-08-30",
            "pageName" : "NORSTENT",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "NORSTENT",
            "title" : "Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease",
            "pmid" : "27572953"
        },
        {
            "timestamp" : "2017-12-03T22:37:53Z",
            "briefDesignDescription" : "Continuous vs. nocturnal oxygen in COPD",
            "fulltexturl" : "http://annals.org/article.aspx?articleid",
            "pageid" : 1788,
            "pdfurl" : "",
            "trainingLevel" : "Student",
            "citation" : "NOTT Group. \"Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group\". <i>Annals of Internal Medicine</i>. 1980. 93(3):91-398.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Nocturnal Oxygen Therapy Trial",
            "statusUsableDate" : "2014-01-01",
            "briefResultsDescription" : "Continuous oxygen reduces mortality in COPD with hypoxemia",
            "published" : "1980-09-01",
            "pageName" : "NOTT",
            "diseases" : "Chronic Obstructive Pulmonary Disease",
            "abbreviation" : "NOTT",
            "title" : "Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group",
            "pmid" : "6776858"
         },
         },
         {
         {
Line 1,705: Line 4,307:
             "subspecialties" : "Oncology",
             "subspecialties" : "Oncology",
             "expansion" : "National Surgical Adjuvant Breast and Bowel Project Trial B-32",
             "expansion" : "National Surgical Adjuvant Breast and Bowel Project Trial B-32",
            "statusUsableDate" : "2013-02-01",
             "briefResultsDescription" : "Sentinel lymph node biopsy is equally efficacious but has fewer side effects than ALND",
             "briefResultsDescription" : "Sentinel lymph node biopsy is equally efficacious but has fewer side effects than ALND",
             "published" : "2010-10-01",
             "published" : "2010-10-01",
Line 1,712: Line 4,315:
             "title" : "Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial",
             "title" : "Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial",
             "pmid" : "20863759"
             "pmid" : "20863759"
        },
        {
            "timestamp" : "2017-12-03T22:37:56Z",
            "briefDesignDescription" : "Tamoxifen in breast cancer prevention",
            "fulltexturl" : "http://jnci.oxfordjournals.org/content/90/18/1371.long",
            "pageid" : 1049,
            "pdfurl" : "http://jnci.oxfordjournals.org/content/90/18/1371.full.pdf+html",
            "trainingLevel" : "resident",
            "citation" : "Fisher B, <i>et al</i>. \"Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study\". <i>Journal of the National Cancer Institute</i>. 1998. 90(18):1371-1388.",
            "subspecialties" : "Oncology;Preventive Medicine",
            "expansion" : "National Surgical Adjuvant Breast and Bowel Project, Prevention-1",
            "statusUsableDate" : "2012-10-01",
            "briefResultsDescription" : "Tamoxifen reduces breast cancer incidence by 48%",
            "published" : "1998-09-16",
            "pageName" : "NSABP P-1",
            "diseases" : "Breast Cancer",
            "abbreviation" : "NSABP P-1",
            "title" : "Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study",
            "pmid" : "9747868"
         },
         },
         {
         {
Line 1,723: Line 4,345:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Fifth Organization to Assess Strategies in Acute Ischemic Syndromes",
             "expansion" : "Fifth Organization to Assess Strategies in Acute Ischemic Syndromes",
            "statusUsableDate" : "2018-04-27",
             "briefResultsDescription" : "Fondaparinux is non-inferior to enoxaparin in NSTE-ACS",
             "briefResultsDescription" : "Fondaparinux is non-inferior to enoxaparin in NSTE-ACS",
             "published" : "2006-04-06",
             "published" : "2006-04-06",
Line 1,730: Line 4,353:
             "title" : "Comparison of fondaparinux and enoxaparin in acute coronary syndromes",
             "title" : "Comparison of fondaparinux and enoxaparin in acute coronary syndromes",
             "pmid" : "16537663"
             "pmid" : "16537663"
        },
        {
            "timestamp" : "2017-12-03T22:37:57Z",
            "briefDesignDescription" : "PCI+OMT vs. OMT 3-28 days after MI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa066139",
            "pageid" : 2676,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa066139",
            "trainingLevel" : "Intern",
            "citation" : "Hochman J.S., <i>et al</i>. \"Coronary Intervention for Persistent Occlusion after Myocardial Infarction\". <i>The New England Journal of Medicine</i>. 2006. 355(23):2395-2407.",
            "subspecialties" : "Cardiology",
            "expansion" : "Occluded Artery Trial",
            "statusUsableDate" : "2016-06-01",
            "briefResultsDescription" : "PCI+OMT no better than OMT 3-28 days after MI",
            "published" : "2006-12-07",
            "pageName" : "OAT",
            "diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
            "abbreviation" : "OAT",
            "title" : "Coronary Intervention for Persistent Occlusion after Myocardial Infarction",
            "pmid" : "17105759"
         },
         },
         {
         {
Line 1,741: Line 4,383:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not\nAdequately Controlled with Their Lipid Modifying Therapy",
             "expansion" : "Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not\nAdequately Controlled with Their Lipid Modifying Therapy",
            "statusUsableDate" : "2015-09-01",
             "briefResultsDescription" : "Alirocumab lowers LDL, reduces non-fatal MI",
             "briefResultsDescription" : "Alirocumab lowers LDL, reduces non-fatal MI",
             "published" : "2015-04-16",
             "published" : "2015-04-16",
Line 1,759: Line 4,402:
             "subspecialties" : "Gastroenterology",
             "subspecialties" : "Gastroenterology",
             "expansion" : null,
             "expansion" : null,
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "IV omeprazole reduced 30-day rebleeding",
             "briefResultsDescription" : "IV omeprazole reduced 30-day rebleeding",
             "published" : "2000-08-03",
             "published" : "2000-08-03",
Line 1,766: Line 4,410:
             "title" : "Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcer",
             "title" : "Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcer",
             "pmid" : "10922420"
             "pmid" : "10922420"
        },
        {
            "timestamp" : "2017-12-03T22:38:00Z",
            "briefDesignDescription" : "Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801317",
            "pageid" : 1776,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801317",
            "trainingLevel" : "Resident",
            "citation" : "Yusuf S, <i>et al</i>. \"Telmisartan, ramipril, or both in patients at high risk for vascular events\". <i>The New England Journal of Medicine</i>. 2008. 358(15):1547-1559.",
            "subspecialties" : "Cardiology;Nephrology;Endocrinology",
            "expansion" : "Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial",
            "statusUsableDate" : "2014-05-01",
            "briefResultsDescription" : "No difference in CV complications, combination ACE-inhibitor and ARB poorly tolerated",
            "published" : "2008-04-10",
            "pageName" : "ONTARGET",
            "diseases" : "Cardiovascular Disease;Diabetes Mellitus;Stroke",
            "abbreviation" : "ONTARGET",
            "title" : "Telmisartan, ramipril, or both in patients at high risk for vascular events",
            "pmid" : "18378520"
        },
        {
            "timestamp" : "2017-12-03T22:38:02Z",
            "briefDesignDescription" : "ASA/warfarin vs. warfarin in AF",
            "fulltexturl" : "http://circ.ahajournals.org/content/128/7/721.long",
            "pageid" : 1769,
            "pdfurl" : "http://circ.ahajournals.org/content/128/7/721.full.pdf",
            "trainingLevel" : "Fellow",
            "citation" : "Steinberg BA, <i>et al</i>. \"Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry\". <i>Circulation</i>. 2013. 128(7):721-8.",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Outcomes Registry for Better Informed Treatment of Atrial Fibrillation",
            "statusUsableDate" : "2014-06-01",
            "briefResultsDescription" : "ASA/warfarin associated with more bleeding, fewer CV events",
            "published" : "2013-08-13",
            "pageName" : "ORBIT-AF",
            "diseases" : "Atrial Fibrillation;Stroke",
            "abbreviation" : "ORBIT-AF",
            "title" : "Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry",
            "pmid" : "23861512"
         },
         },
         {
         {
Line 1,777: Line 4,459:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina",
             "expansion" : "Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina",
            "statusUsableDate" : "2017-12-14",
             "briefResultsDescription" : "PCI not superior to medical therapy in stable angina",
             "briefResultsDescription" : "PCI not superior to medical therapy in stable angina",
             "published" : "2017-11-02",
             "published" : "2017-11-02",
Line 1,784: Line 4,467:
             "title" : "Percutaneous coronary intervention in stable angina",
             "title" : "Percutaneous coronary intervention in stable angina",
             "pmid" : "29103656"
             "pmid" : "29103656"
        },
        {
            "timestamp" : "2017-12-03T22:38:03Z",
            "briefDesignDescription" : "Fish oil for high-risk CVD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1203859",
            "pageid" : 2330,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1203859",
            "trainingLevel" : "Intern",
            "citation" : "Bosch J, <i>et al</i>. \"n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia\". <i>The New England Journal of Medicine</i>. 2012. 367(4):309-318.",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Investigators in the outcome Reduction with an Initial Glargine Intervention",
            "statusUsableDate" : "2015-02-01",
            "briefResultsDescription" : "n-3 fatty acids don't reduce CVD",
            "published" : "2012-07-26",
            "pageName" : "ORIGIN n-3 Fatty Acids",
            "diseases" : "Cardiovascular Disease;Coronary Artery Disease;Stroke",
            "abbreviation" : "ORIGIN n-3 Fatty Acids",
            "title" : "n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia",
            "pmid" : "22686415"
        },
        {
            "timestamp" : "2017-12-03T22:38:05Z",
            "briefDesignDescription" : "High-frequency oscillatory vent in early ARDS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1215554",
            "pageid" : 1254,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1215554",
            "trainingLevel" : "Resident",
            "citation" : "Ferguson ND, <i>et al</i>. \"High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome\". <i>The New England Journal of Medicine</i>. 2013. 368(9):795-805.",
            "subspecialties" : "Critical Care;Pulmonology",
            "expansion" : "Oscillation for Acute Respiratory Distress Syndrome Treated Early",
            "statusUsableDate" : "2013-09-01",
            "briefResultsDescription" : "High-frequency oscillatory vent may harm in early ARDS",
            "published" : "2013-02-28",
            "pageName" : "OSCILLATE",
            "diseases" : "Acute Respiratory Distress Syndrome",
            "abbreviation" : "Oscillate",
            "title" : "High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome",
            "pmid" : "23339639"
         },
         },
         {
         {
Line 1,795: Line 4,516:
             "subspecialties" : "Surgery;Gastroenterology",
             "subspecialties" : "Surgery;Gastroenterology",
             "expansion" : "Minimally Invasive Step Up Approach versus Maximal Necrosectomy in Patients with Acute Necrotising Pancreatitis",
             "expansion" : "Minimally Invasive Step Up Approach versus Maximal Necrosectomy in Patients with Acute Necrotising Pancreatitis",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Step-up approach reduces major complications and death",
             "briefResultsDescription" : "Step-up approach reduces major complications and death",
             "published" : "2010-04-22",
             "published" : "2010-04-22",
Line 1,813: Line 4,535:
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure",
             "expansion" : "Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure",
            "statusUsableDate" : "2014-09-01",
             "briefResultsDescription" : "ARNI reduces mortality in HFrEF",
             "briefResultsDescription" : "ARNI reduces mortality in HFrEF",
             "published" : "2014-08-30",
             "published" : "2014-08-30",
Line 1,822: Line 4,545:
         },
         },
         {
         {
             "timestamp" : "2015-07-06T21:57:52Z",
             "timestamp" : "2017-12-03T22:38:08Z",
             "briefDesignDescription" : "Pentoxifylline in alcoholic hepatitis",
             "briefDesignDescription" : "Maintenance pemetrexed in lung cancer",
             "fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(00)51183-4/fulltext",
             "fulltexturl" : "http://jco.ascopubs.org/content/31/23/2895.long",
             "pageid" : 53,
             "pageid" : 1606,
             "pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0016-5085/PIIS0016508500511834.pdf",
             "pdfurl" : "http://jco.ascopubs.org/content/31/23/2895.full.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Fellow",
             "citation" : "Akriviadis E, <i>et al</i>. \"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial\". <i>Gastroenterology</i>. 2000. 119(6):1637-48.",
             "citation" : "Paz-Ares LG, <i>et al</i>. \"PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer\". <i>Journal of Clinical Oncology</i>. 2013. 31(23):2895-902.",
             "subspecialties" : "Gastroenterology",
             "subspecialties" : "Oncology",
             "expansion" : "",
             "expansion" : "",
             "briefResultsDescription" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis",
            "statusUsableDate" : "2014-01-01",
             "published" : "2000-12-20",
             "briefResultsDescription" : "Maintenance pemetrexed improves PFS and OS following induction with cisplatin/pemetrexed",
             "pageName" : "Pentoxifylline in Severe Alcoholic Hepatitis",
             "published" : "2013-08-10",
             "diseases" : "Alcoholic Hepatitis",
             "pageName" : "PARAMOUNT",
             "abbreviation" : "",
             "diseases" : "Lung Cancer",
             "title" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial",
             "abbreviation" : "PARAMOUNT",
             "pmid" : "11113085"
             "title" : "PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer",
             "pmid" : "23835707"
         },
         },
         {
         {
             "timestamp" : "2016-04-05T13:46:19Z",
             "timestamp" : "2017-12-03T22:38:09Z",
             "briefDesignDescription" : "Accuracy of CT for PE",
            "briefDesignDescription" : "TAVI for AS in intermediate-risk surgical candidates",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052367#t",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1514616",
             "pageid" : 161,
            "pageid" : 2753,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052367#t",
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1514616",
             "trainingLevel" : "MedicalStudent",
            "trainingLevel" : "Resident",
             "citation" : "Stein PD, <i>et al</i>. \"Multidetector Computed Tomography for Acute Pulmonary Embolism\". <i>The New England Journal of Medicine</i>. 2006. 354(22):2317-2327.",
            "citation" : "Leon MB, <i>et al</i>. \"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients\". <i>The New England Journal of Medicine</i>. 2016. 374(17):1609-20.",
             "subspecialties" : "Pulmonology;Hematology",
            "subspecialties" : "Cardiology",
             "expansion" : "Prospective Investigation of Pulmonary Embolism Diagnosis II",
            "expansion" : "Placement of Aortic Transcatheter Valves, Cohort A",
             "briefResultsDescription" : "CT sensitive and specific in detecting acute PE",
            "statusUsableDate" : "2016-05-01",
             "published" : "2006-06-01",
            "briefResultsDescription" : "TAVI noninferior to surgical AVR in intermediate-risk surgical candidates",
             "pageName" : "PIOPED II",
            "published" : "2016-04-28",
             "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
            "pageName" : "PARTNER 2",
             "abbreviation" : "PIOPED II",
            "diseases" : "Aortic Stenosis",
             "title" : "Multidetector Computed Tomography for Acute Pulmonary Embolism",
            "abbreviation" : "PARTNER 2",
             "pmid" : "16738268"
            "title" : "Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients",
            "pmid" : "27040324"
        },
        {
            "timestamp" : "2017-12-03T22:38:10Z",
             "briefDesignDescription" : "TAVI for AS in high-risk surgical candidates",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1103510",
             "pageid" : 2741,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1103510",
             "trainingLevel" : "Intern",
             "citation" : "Smith CR, <i>et al</i>. \"Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients\". <i>The New England Journal of Medicine</i>. 2011. 364(23):2187-98.",
             "subspecialties" : "Cardiology",
             "expansion" : "Placement of Aortic Transcatheter Valves, Cohort A",
            "statusUsableDate" : "2016-05-01",
             "briefResultsDescription" : "TAVI noninferior to surgical AVR in high-risk surgical candidates",
             "published" : "2011-06-09",
             "pageName" : "PARTNER A",
             "diseases" : "Aortic Stenosis",
             "abbreviation" : "PARTNER A",
             "title" : "Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients",
             "pmid" : "21639811"
         },
         },
         {
         {
             "timestamp" : "2012-05-07T02:36:42Z",
             "timestamp" : "2017-12-03T22:38:12Z",
             "briefDesignDescription" : "8 vs. 15 days of antibiotics in VAP",
             "briefDesignDescription" : "TAVI for AS in poor surgical candidates",
             "fulltexturl" : "http://jama.ama-assn.org/content/290/19/2588.long",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1008232",
             "pageid" : 118,
             "pageid" : 1674,
             "pdfurl" : "http://jama.ama-assn.org/content/290/19/2588.full.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1008232",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Chastre J. \"Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial\". <i>Journal of the American Medical Association</i>. 2003. 290(19):2588-98.",
             "citation" : "Leon MB, <i>et al</i>. \"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery\". <i>The New England Journal of Medicine</i>. 2010. 363(17):1597-1607.",
             "subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Placement of Aortic Transcatheter Valves, Cohort B",
             "briefResultsDescription" : "8 days of antibiotics are equivalent to 15 days",
            "statusUsableDate" : "2013-12-01",
             "published" : "2003-11-19",
             "briefResultsDescription" : "TAVI reduces all-cause mortality ± rehospitalization, increased stroke",
             "pageName" : "PneumA",
             "published" : "2010-10-21",
             "diseases" : "Pneumonia",
             "pageName" : "PARTNER B",
             "abbreviation" : "PneumA",
             "diseases" : "Aortic Stenosis",
             "title" : "Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial",
             "abbreviation" : "PARTNER B",
             "pmid" : "14625336"
             "title" : "Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery",
             "pmid" : "20961243"
         },
         },
         {
         {
             "timestamp" : "2018-08-09T15:54:11Z",
             "timestamp" : "2017-12-03T22:38:13Z",
             "briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin in stroke/TIA",
             "briefDesignDescription" : "Finasteride for prostate cancer prophylaxis",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800410",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030660",
             "pageid" : 3659,
             "pageid" : 1786,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800410",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030660",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Johnston SC, <i>et al</i>. \"Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA\". <i>The New England Journal of Medicine</i>. 2018. 379(3):215-225.",
             "citation" : "Thompson IM, <i>et al</i>. \"The influence of finasteride on the development of prostate cancer\". <i>The New England Journal of Medicine</i>. 2003. 349(3):215-224.",
             "subspecialties" : "Neurology",
             "subspecialties" : "Urology;Oncology",
             "expansion" : "Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial",
             "expansion" : "Prostate Cancer Prevention Trial",
             "briefResultsDescription" : "Aspirin/clopidogrel reduces stroke recurrence, increases bleeding compared to aspirin",
            "statusUsableDate" : "2014-02-01",
             "published" : "2018-05-16",
             "briefResultsDescription" : "Finasteride reduces all-grade prostate cancer risk, increases high-grade disease",
             "pageName" : "POINT",
             "published" : "2003-07-13",
             "diseases" : "Stroke;Transient Ischemic Attack",
             "pageName" : "PCPT",
             "abbreviation" : "POINT",
             "diseases" : "Prostate Cancer",
             "title" : "Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA",
             "abbreviation" : "PCPT",
             "pmid" : "29766750"
             "title" : "The influence of finasteride on the development of prostate cancer",
             "pmid" : "12824459"
         },
         },
         {
         {
             "timestamp" : "2014-10-17T07:39:25Z",
             "timestamp" : "2017-12-03T22:38:15Z",
             "briefDesignDescription" : "Perioperative metoprolol",
             "briefDesignDescription" : "Extended ticagrelor+ASA after MI",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)60601-7/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1500857",
             "pageid" : 173,
             "pageid" : 2469,
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673608606017.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500857",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Devereaux PJ, <i>et al</i>. \"Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial\". <i>The Lancet</i>. 2008. 371(9627):1839-1847.",
             "citation" : "Bonaca MP, <i>et al</i>. \"Long-term use of ticagrelor in patients with prior myocardial infarction\". <i>The New England Journal of Medicine</i>. 2015. 372(19):1791-1800.",
             "subspecialties" : "Surgery;Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "PeriOperative ISchemic Evaluation",
             "expansion" : "",
             "briefResultsDescription" : "Perioperative metoprolol reduces MI risk but increases risk of mortality and stroke",
            "statusUsableDate" : "2015-12-01",
             "published" : "2008-05-31",
             "briefResultsDescription" : "Extended ticagrelor+ASA reduces CVD events after MI",
             "pageName" : "POISE",
             "published" : "2015-05-07",
             "diseases" : "Cardiac Risk Assessment;Coronary Artery Disease",
             "pageName" : "PEGASUS-TIMI 54",
             "abbreviation" : "POISE",
             "diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
             "title" : "Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial",
             "abbreviation" : "PEGASUS-TIMI 54",
             "pmid" : "18479744"
             "title" : "Long-term use of ticagrelor in patients with prior myocardial infarction",
             "pmid" : "25773268"
         },
         },
         {
         {
             "timestamp" : "2018-06-01T20:19:38Z",
             "timestamp" : "2017-12-03T22:38:16Z",
             "briefDesignDescription" : "Celecoxib, naproxen, or ibuprofen for CV safety in arthritis",
             "briefDesignDescription" : "tPA for submassive PE",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611593",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1302097",
             "pageid" : 2888,
            "pageid" : 1778,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611593",
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1302097",
            "trainingLevel" : "resident",
            "citation" : "Meyer G, <i>et al</i>. \"Fibrinolysis for patients with intermediate-risk pulmonary embolism\". <i>The New England Journal of Medicine</i>. 2014. 370(15):1402-1411.",
            "subspecialties" : "Critical Care;Pulmonology;Hematology",
            "expansion" : "Pulmonary Embolism Thrombolysis trial",
            "statusUsableDate" : "2014-04-01",
            "briefResultsDescription" : "tPA reduces hemodynamic decomp, not mortality, also increases bleeding in submassive PE",
            "published" : "2014-04-10",
            "pageName" : "PEITHO",
            "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
            "abbreviation" : "PEITHO",
            "title" : "Fibrinolysis for patients with intermediate-risk pulmonary embolism",
            "pmid" : "24716681"
        },
        {
            "timestamp" : "2015-07-06T21:57:52Z",
            "briefDesignDescription" : "Pentoxifylline in alcoholic hepatitis",
            "fulltexturl" : "http://www.gastrojournal.org/article/S0016-5085(00)51183-4/fulltext",
            "pageid" : 53,
            "pdfurl" : "http://download.journals.elsevierhealth.com/pdfs/journals/0016-5085/PIIS0016508500511834.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Akriviadis E, <i>et al</i>. \"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial\". <i>Gastroenterology</i>. 2000. 119(6):1637-48.",
            "subspecialties" : "Gastroenterology",
            "expansion" : "",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis",
            "published" : "2000-12-20",
            "pageName" : "Pentoxifylline in Severe Alcoholic Hepatitis",
            "diseases" : "Alcoholic Hepatitis",
            "abbreviation" : "",
            "title" : "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial",
            "pmid" : "11113085"
        },
        {
            "timestamp" : "2017-12-03T22:38:18Z",
            "briefDesignDescription" : "Prevalence of PE in syncope",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602172",
             "pageid" : 2843,
             "pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602172",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Nissen SE, <i>et al</i>. \"Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis\". <i>The New England Journal of Medicine</i>. 2016. 375(26):2519-2529.",
             "citation" : "Prandoni P, <i>et al</i>. \"Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope\". <i>The New England Journal of Medicine</i>. 2016. 375(16):1524-31.",
             "subspecialties" : "Cardiology;Rheumatology;Neurology",
             "subspecialties" : "Hematology",
             "expansion" : "Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen",
             "expansion" : "Pulmonary Embolism in Syncope Italian Trial",
             "briefResultsDescription" : "Celecoxib noninferior to ibuprofen or naproxen with regard to CV safety",
            "statusUsableDate" : "2016-11-01",
             "published" : "2016-12-29",
             "briefResultsDescription" : "PE found in 1 of 6 patients with syncope",
             "pageName" : "PRECISION",
             "published" : "2016-10-20",
             "diseases" : "Coronary Artery Disease;Rheumatoid Arthritis;Osteoarthritis;Stroke",
             "pageName" : "PESIT",
             "abbreviation" : "PRECISION",
             "diseases" : "Pulmonary Embolism;Venous Thromboembolism;Syncope",
             "title" : "Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis",
             "abbreviation" : "PESIT",
             "pmid" : "27959716"
             "title" : "Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope",
             "pmid" : "27797317"
         },
         },
         {
         {
             "timestamp" : "2018-06-14T20:17:40Z",
             "timestamp" : "2017-12-03T22:38:19Z",
             "briefDesignDescription" : "Mediterranean diet in CVD prevention",
             "briefDesignDescription" : "DOAC, VKA, antiplatelets after PCI with stent",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200303",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611594",
             "pageid" : 1247,
             "pageid" : 2861,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200303",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611594",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Estruch R, <i>et al</i>. \"Primary prevention of cardiovascular disease with a mediterranean diet\". <i>The New England Journal of Medicine</i>. 2013. 368(14):1279-1290.",
             "citation" : "Gibson CM, <i>et al</i>. \"Prevention of bleeding in patients with AF undergoing PCI\". <i>The New England Journal of Medicine</i>. 2016. epub 2016-11-14:1-12.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Prevención con Dieta Mediterránea",
             "expansion" : "Open-Label, Randomized, Controlled, Multicenter Study Exploring Two Treatment Strategies of Rivaroxaban and a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy in Subjects with AF who Undergo Percutaneous Coronary Intervention",
             "briefResultsDescription" : "Mediterranean diet reduces composite rate of MI/CVA/CV death",
            "statusUsableDate" : "2016-12-01",
             "published" : "2013-02-25",
             "briefResultsDescription" : "Rivaroxaban with lower bleeding",
             "pageName" : "PREDIMED",
             "published" : "2016-11-14",
             "diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
             "pageName" : "PIONEER AF-PCI",
             "abbreviation" : "PREDIMED",
             "diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
             "title" : "Primary prevention of cardiovascular disease with a mediterranean diet",
             "abbreviation" : "PIONEER AF-PCI",
             "pmid" : "23432189"
             "title" : "Prevention of bleeding in patients with AF undergoing PCI",
             "pmid" : "27959713"
         },
         },
         {
         {
             "timestamp" : "2015-07-06T21:57:28Z",
             "timestamp" : "2016-04-05T13:46:19Z",
             "briefDesignDescription" : "Prednisolone vs. placebo in alcoholic hepatitis",
             "briefDesignDescription" : "Accuracy of CT for PE",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199202203260802",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052367#t",
             "pageid" : 1113,
             "pageid" : 161,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199202203260802",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052367#t",
             "trainingLevel" : "Intern",
             "trainingLevel" : "MedicalStudent",
             "citation" : "Ramond MJ, <i>et al</i>. \"A randomized trial of prednisolone in patients with severe alcoholic hepatitis\". <i>The New England Journal of Medicine</i>. 1992. 362(8):507-512.",
             "citation" : "Stein PD, <i>et al</i>. \"Multidetector Computed Tomography for Acute Pulmonary Embolism\". <i>The New England Journal of Medicine</i>. 2006. 354(22):2317-2327.",
             "subspecialties" : "Gastroenterology",
             "subspecialties" : "Pulmonology;Hematology",
             "expansion" : "",
             "expansion" : "Prospective Investigation of Pulmonary Embolism Diagnosis II",
             "briefResultsDescription" : "Prednisolone improves short-term survival",
            "statusUsableDate" : "2012-03-01",
             "published" : "1992-02-20",
             "briefResultsDescription" : "CT sensitive and specific in detecting acute PE",
             "pageName" : "Prednisolone in Severe Alcoholic Hepatitis",
             "published" : "2006-06-01",
             "diseases" : "Alcoholic Hepatitis",
             "pageName" : "PIOPED II",
             "abbreviation" : "",
             "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
             "title" : "A randomized trial of prednisolone in patients with severe alcoholic hepatitis",
             "abbreviation" : "PIOPED II",
             "pmid" : "1531090"
             "title" : "Multidetector Computed Tomography for Acute Pulmonary Embolism",
             "pmid" : "16738268"
         },
         },
         {
         {
             "timestamp" : "2017-08-06T02:15:05Z",
             "timestamp" : "2017-12-03T22:38:21Z",
             "briefDesignDescription" : "Procalcitonin-guided antibiotics",
             "briefDesignDescription" : "Probiotics to prevent CDAD",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61879-1/fulltext",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2961218-0/abstract",
             "pageid" : 434,
             "pageid" : 1770,
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673609618791.pdf",
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673613612180.pdf",
             "trainingLevel" : "resident",
             "trainingLevel" : "Resident",
             "citation" : "Bouadma L, <i>et al</i>. \"Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units\". <i>The Lancet</i>. 2010. 375(9713):463-74.",
             "citation" : "Allen SJ, <i>et al</i>. \"Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial\". <i>The Lancet</i>. 2013. 382(9900):1249-1257.",
             "subspecialties" : "Critical Care;Infectious Disease",
             "subspecialties" : "Gastroenterology;Infectious Disease;Preventive Medicine",
             "expansion" : "Procalcitonin to Reduce Antibiotic Treatments in Acutely ill patients",
             "expansion" : "",
             "briefResultsDescription" : "Procalcitonin noninferior and led to fewer days on antibiotics",
            "statusUsableDate" : "2014-05-01",
             "published" : "2010-02-06",
             "briefResultsDescription" : "Probiotics do not reduce diarrhea including C. diff with antibiotics",
             "pageName" : "PRORATA",
             "published" : "2013-10-12",
             "diseases" : "Critical Illness",
             "pageName" : "PLACIDE",
             "abbreviation" : "PRORATA",
             "diseases" : "Clostridium difficile",
             "title" : "Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units",
             "abbreviation" : "PLACIDE",
             "pmid" : "20097417"
             "title" : "Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): A randomised, double-blind, placebo-controlled, multicentre trial",
             "pmid" : "23932219"
         },
         },
         {
         {
             "timestamp" : "2018-01-22T20:17:30Z",
             "timestamp" : "2017-12-03T22:38:22Z",
             "briefDesignDescription" : "LAA closure vs. warfarin in AF",
             "briefDesignDescription" : "Ticagrelor vs. clopidogrel in ACS",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61343-X/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0904327",
             "pageid" : 2459,
             "pageid" : 1629,
             "pdfurl" : "",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0904327",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Holmes DR, <i>et al</i>. \"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial\". <i>Lancet</i>. 2009. 374(9689):534-42.",
             "citation" : "Wallentin L, <i>et al</i>. \"Ticagrelor versus clopidogrel in patients with acute coronary syndromes\". <i>The New England Journal of Medicine</i>. 2009. 361(11):1045-1057.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation",
             "expansion" : "Platelet Inhibition and Patient Outcomes",
             "briefResultsDescription" : "LAA closure was noninferior to warfarin therapy",
            "statusUsableDate" : "2013-09-01",
             "published" : "2009-11-07",
            "briefResultsDescription" : "Ticagrelor reduces mortality, increases bleeding",
             "pageName" : "PROTECT AF",
            "published" : "2009-09-10",
             "diseases" : "Atrial Fibrillation;Stroke",
            "pageName" : "PLATO",
             "abbreviation" : "PROTECT AF",
            "diseases" : "Acute Coronary Syndrome;Coronary Artery Disease",
             "title" : "Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial",
            "abbreviation" : "PLATO",
             "pmid" : "19683639"
            "title" : "Ticagrelor versus clopidogrel in patients with acute coronary syndromes",
            "pmid" : "19717846"
        },
        {
            "timestamp" : "2012-05-07T02:36:42Z",
            "briefDesignDescription" : "8 vs. 15 days of antibiotics in VAP",
            "fulltexturl" : "http://jama.ama-assn.org/content/290/19/2588.long",
            "pageid" : 118,
            "pdfurl" : "http://jama.ama-assn.org/content/290/19/2588.full.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Chastre J. \"Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial\". <i>Journal of the American Medical Association</i>. 2003. 290(19):2588-98.",
            "subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
            "expansion" : "",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "8 days of antibiotics are equivalent to 15 days",
             "published" : "2003-11-19",
             "pageName" : "PneumA",
             "diseases" : "Pneumonia",
             "abbreviation" : "PneumA",
             "title" : "Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial",
             "pmid" : "14625336"
         },
         },
         {
         {
             "timestamp" : "2017-12-14T19:39:45Z",
             "timestamp" : "2018-08-09T15:54:11Z",
             "briefDesignDescription" : "Pravastatin vs. atorvastatin after ACS",
             "briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin in stroke/TIA",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040583",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1800410",
             "pageid" : 1338,
             "pageid" : 3659,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040583",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1800410",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Cannon CP, <i>et al</i>. \"Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2004. 350(15):1495-1504.",
             "citation" : "Johnston SC, <i>et al</i>. \"Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA\". <i>The New England Journal of Medicine</i>. 2018. 379(3):215-225.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Neurology",
             "expansion" : "Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22",
             "expansion" : "Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial",
             "briefResultsDescription" : "High-dose atorvastatin is superior to moderate-dose pravastatin at reducing CV events after ACS",
            "statusUsableDate" : "2018-08-09",
             "published" : "2004-04-08",
             "briefResultsDescription" : "Aspirin/clopidogrel reduces stroke recurrence, increases bleeding compared to aspirin",
             "pageName" : "PROVE IT-TIMI 22",
             "published" : "2018-05-16",
             "diseases" : "Acute Coronary Syndrome;Hyperlipidemia",
             "pageName" : "POINT",
             "abbreviation" : "PROVE IT-TIMI 22",
             "diseases" : "Stroke;Transient Ischemic Attack",
             "title" : "Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes",
             "abbreviation" : "POINT",
             "pmid" : "15007110"
             "title" : "Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA",
             "pmid" : "29766750"
         },
         },
         {
         {
             "timestamp" : "2018-06-14T20:42:56Z",
             "timestamp" : "2014-10-17T07:39:25Z",
             "briefDesignDescription" : "Basal-bolus insulin in inpatients with DM",
             "briefDesignDescription" : "Perioperative metoprolol",
             "fulltexturl" : "http://bit.ly/29xvPia",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)60601-7/fulltext",
             "pageid" : 2720,
             "pageid" : 173,
             "pdfurl" : "http://care.diabetesjournals.org/content/30/9/2181.full-text.pdf",
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673608606017.pdf",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Umpierrez GE, <i>et al</i>. \"Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)\". <i>Diabetes Care</i>. 2007. 30(9):2181-2186.",
             "citation" : "Devereaux PJ, <i>et al</i>. \"Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial\". <i>The Lancet</i>. 2008. 371(9627):1839-1847.",
             "subspecialties" : "Critical care;Endocrinology",
             "subspecialties" : "Surgery;Cardiology",
             "expansion" : "Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes",
             "expansion" : "PeriOperative ISchemic Evaluation",
             "briefResultsDescription" : "Basal-bolus more effective for glycemic control compared to sliding-scale insulin",
            "statusUsableDate" : "2012-03-01",
             "published" : "2007-09-30",
            "briefResultsDescription" : "Perioperative metoprolol reduces MI risk but increases risk of mortality and stroke",
             "pageName" : "RABBIT 2",
            "published" : "2008-05-31",
             "diseases" : "Diabetes Mellitus",
            "pageName" : "POISE",
             "abbreviation" : "RABBIT 2",
            "diseases" : "Cardiac Risk Assessment;Coronary Artery Disease",
             "title" : "Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)",
            "abbreviation" : "POISE",
             "pmid" : "17513708"
            "title" : "Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery: a Randomised Controlled Trial",
            "pmid" : "18479744"
        },
        {
            "timestamp" : "2017-12-03T22:38:24Z",
            "briefDesignDescription" : "Perioperative ASA",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1401105",
            "pageid" : 1777,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1401105",
            "trainingLevel" : "Intern",
            "citation" : "Devereaux PJ, <i>et al</i>. \"Aspirin in patients undergoing noncardiac surgery\". <i>The New England Journal of Medicine</i>. 2014. 370(16):1494-1503.",
            "subspecialties" : "Cardiology;Surgery",
            "expansion" : "Perioperative ischemic evaluation 2 aspirin arm",
             "statusUsableDate" : "2014-04-01",
            "briefResultsDescription" : "Perioperative ASA doesn't modify MI rates but increases major bleeding",
             "published" : "2014-03-31",
             "pageName" : "POISE-2 ASA",
             "diseases" : "Cardiac Risk Assessment",
             "abbreviation" : "POISE-2 ASA",
             "title" : "Aspirin in patients undergoing noncardiac surgery",
            "pmid" : "24679062"
        },
        {
            "timestamp" : "2017-12-03T22:38:25Z",
            "briefDesignDescription" : "PPIs for stress ulcer prophylaxis",
            "fulltexturl" : "https://dx.doi.org/10.1097/CCM.0000000000001819",
            "pageid" : 2866,
            "pdfurl" : "http://ovidsp.tx.ovid.com/sp-3.26.1a/ovidweb.cgi?&S",
            "trainingLevel" : "Resident",
            "citation" : "Selvanderan SP, <i>et al</i>. \"Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study\". <i>Critical Care Medicine</i>. 2016. 44(10):1842-1850.",
            "subspecialties" : "Critical Care",
            "expansion" : "Pantoprazole or Placebo for Stress Ulcer Prophylaxis",
            "statusUsableDate" : "2017-09-01",
            "briefResultsDescription" : "PPIs do not reduce risk of stress ulcer bleeding in enterally fed patients",
            "published" : "2016-10-01",
            "pageName" : "POP-UP",
            "diseases" : "Stress Ulcer",
            "abbreviation" : "POP-UP",
            "title" : "Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study",
             "pmid" : "27635481"
         },
         },
         {
         {
             "timestamp" : "2014-05-22T00:30:05Z",
             "timestamp" : "2017-12-03T22:38:27Z",
             "briefDesignDescription" : "Lenient vs. strict rate control in AF",
             "briefDesignDescription" : "PCI to high-risk non-infarct arteries in STEMI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001337",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1305520",
             "pageid" : 181,
             "pageid" : 1748,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001337",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1305520",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Van Gelder IC, <i>et al</i>. \"Lenient versus Strict Rate Control in Patients with Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2010. 362(15):1363-73.",
             "citation" : "Wald DS, <i>et al</i>. \"Randomized trial of preventative angioplasty in myocardial infarction\". <i>The New England Journal of Medicine</i>. 2013. 369(12):1115-1123.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Rate Control Efficacy in Permanent Atrial Fibrillation: a Comparison between Lenient versus Strict Rate Control II",
             "expansion" : "Preventative Angioplasty in Acute Myocardial Infarction",
             "briefResultsDescription" : "Lenient rate control is as effective as strict rate control",
            "statusUsableDate" : "2013-11-01",
             "published" : "2010-04-15",
             "briefResultsDescription" : "PCI to high-risk non infarct arteries in STEMI improves CV outcomes",
             "pageName" : "RACE II",
             "published" : "2013-09-19",
             "diseases" : "Atrial Fibrillation",
             "pageName" : "PRAMI",
             "abbreviation" : "RACE II",
             "diseases" : "Myocardial Infarction",
             "title" : "Lenient versus Strict Rate Control in Patients with Atrial Fibrillation",
             "abbreviation" : "PRAMI",
             "pmid" : "20231232"
             "title" : "Randomized trial of preventative angioplasty in myocardial infarction",
             "pmid" : "23991625"
         },
         },
         {
         {
             "timestamp" : "2015-08-24T04:40:44Z",
             "timestamp" : "2018-06-01T20:19:38Z",
             "briefDesignDescription" : "Spironolactone in HFrEF",
             "briefDesignDescription" : "Celecoxib, naproxen, or ibuprofen for CV safety in arthritis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199909023411001",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611593",
             "pageid" : 11,
             "pageid" : 2888,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199909023411001",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611593",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Pitt B, <i>et al</i>. \"The effect of spironolactone on morbidity and mortality in patients with severe heart failure\". <i>New England Journal of Medicine</i>. 1999. 341(10):709-717.",
             "citation" : "Nissen SE, <i>et al</i>. \"Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis\". <i>The New England Journal of Medicine</i>. 2016. 375(26):2519-2529.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology;Rheumatology;Neurology",
             "expansion" : "Randomized Aldactone Evaluation Study",
             "expansion" : "Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen",
             "briefResultsDescription" : "Spironolactone reduces all-cause mortality by 30% in severe HFrEF",
            "statusUsableDate" : "2017-03-01",
             "published" : "1999-09-02",
             "briefResultsDescription" : "Celecoxib noninferior to ibuprofen or naproxen with regard to CV safety",
             "pageName" : "RALES",
             "published" : "2016-12-29",
             "diseases" : "Heart Failure",
             "pageName" : "PRECISION",
             "abbreviation" : "RALES",
             "diseases" : "Coronary Artery Disease;Rheumatoid Arthritis;Osteoarthritis;Stroke",
             "title" : "The effect of spironolactone on morbidity and mortality in patients with severe heart failure",
             "abbreviation" : "PRECISION",
             "pmid" : "10471456"
             "title" : "Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis",
             "pmid" : "27959716"
         },
         },
         {
         {
             "timestamp" : "2018-01-30T17:09:14Z",
             "timestamp" : "2018-06-14T20:17:40Z",
             "briefDesignDescription" : "Triple therapy vs. ASA+dabigatran in PCI if AF",
             "briefDesignDescription" : "Mediterranean diet in CVD prevention",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1708454",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200303",
             "pageid" : 3527,
             "pageid" : 1247,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1708454",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200303",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Cannon CP, <i>et al</i>. \"Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2017. 377(16):1513-1524.",
             "citation" : "Estruch R, <i>et al</i>. \"Primary prevention of cardiovascular disease with a mediterranean diet\". <i>The New England Journal of Medicine</i>. 2013. 368(14):1279-1290.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Randomized evaluation of dual antithrombotic therapy with dabigatran versus triple therapy with warfarin in patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention",
             "expansion" : "Prevención con Dieta Mediterránea",
             "briefResultsDescription" : "Aspirin and dabigatran nonferior to triple therapy in patients with AF undergoing PCI",
            "statusUsableDate" : "2013-06-01",
             "published" : "2017-10-19",
             "briefResultsDescription" : "Mediterranean diet reduces composite rate of MI/CVA/CV death",
             "pageName" : "RE-DUAL",
             "published" : "2013-02-25",
             "diseases" : "Coronary Artery Disease",
             "pageName" : "PREDIMED",
             "abbreviation" : "RE-DUAL PCI",
             "diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
             "title" : "Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation",
             "abbreviation" : "PREDIMED",
             "pmid" : "28844193"
             "title" : "Primary prevention of cardiovascular disease with a mediterranean diet",
             "pmid" : "23432189"
         },
         },
         {
         {
             "timestamp" : "2015-04-18T21:22:31Z",
             "timestamp" : "2015-07-06T21:57:28Z",
             "briefDesignDescription" : "Dabigatran vs. warfarin in AF",
             "briefDesignDescription" : "Prednisolone vs. placebo in alcoholic hepatitis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0905561",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199202203260802",
             "pageid" : 178,
             "pageid" : 1113,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0905561",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199202203260802",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Connolly SJ, <i>et al</i>. \"Dabigatran versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2009. 361(12):1139-51.",
             "citation" : "Ramond MJ, <i>et al</i>. \"A randomized trial of prednisolone in patients with severe alcoholic hepatitis\". <i>The New England Journal of Medicine</i>. 1992. 362(8):507-512.",
             "subspecialties" : "Cardiology;Neurology",
             "subspecialties" : "Gastroenterology",
             "expansion" : "Randomized Evaluation of Long-Term Anticoagulation Therapy",
             "expansion" : "",
             "briefResultsDescription" : "High-dose dabigatran reduces stroke risk without increasing major bleeding in atrial fibrillation",
            "statusUsableDate" : "2012-03-01",
             "published" : "2009-09-17",
             "briefResultsDescription" : "Prednisolone improves short-term survival",
             "pageName" : "RE-LY",
             "published" : "1992-02-20",
             "diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
             "pageName" : "Prednisolone in Severe Alcoholic Hepatitis",
             "abbreviation" : "RE-LY",
             "diseases" : "Alcoholic Hepatitis",
             "title" : "Dabigatran versus warfarin in patients with atrial fibrillation",
             "abbreviation" : "",
             "pmid" : "19717844"
             "title" : "A randomized trial of prednisolone in patients with severe alcoholic hepatitis",
             "pmid" : "1531090"
         },
         },
         {
         {
             "timestamp" : "2018-07-22T21:45:32Z",
             "timestamp" : "2017-12-03T22:38:31Z",
             "briefDesignDescription" : "Craniectomy vs. medical care for intracranial hypertension",
             "briefDesignDescription" : "IVC filters for proximal DVT",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1605215",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199802123380701",
             "pageid" : 3596,
             "pageid" : 2697,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1605215",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199802123380701",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Hutchinson PJ, <i>et al</i>. \"Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension\". <i>The New England Journal of Medicine</i>. 2016. 375(12):1119-30.",
             "citation" : "Decousus H, <i>et al</i>. \"A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis\". <i>The New England Journal of Medicine</i>. 1998. 338(7):409-416.",
             "subspecialties" : "Surgery;Neurology",
             "subspecialties" : "Pulmonology;Hematology;Interventional Radiology",
             "expansion" : "Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure",
             "expansion" : "Prévention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group",
             "briefResultsDescription" : "Craniectomy reduced mortality by 22% compared to usual care",
            "statusUsableDate" : "2016-03-01",
             "published" : "2016-09-22",
            "briefResultsDescription" : "IVC filters reduce future PE risk but increase DVT risk",
             "pageName" : "RESCUEicp",
            "published" : "1998-02-12",
             "diseases" : "Intracranial Hypertension;Traumatic Brain Injury",
            "pageName" : "PREPIC",
             "abbreviation" : "RESCUEicp",
            "diseases" : "Deep Vein Thrombosis;Venous Thromboembolism;Pulmonary Embolism",
             "title" : "Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension",
            "abbreviation" : "PREPIC",
             "pmid" : "27602507"
            "title" : "A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis",
            "pmid" : "9459643"
        },
        {
            "timestamp" : "2017-12-03T22:38:33Z",
            "briefDesignDescription" : "IVC filters for high-risk PE",
            "fulltexturl" : "http://bit.ly/1Jti6Ct",
            "pageid" : 2405,
            "pdfurl" : "http://bit.ly/1ONs0iA",
            "trainingLevel" : "Intern",
            "citation" : "Mismetti P, <i>et al</i>. \"Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial\". <i>The Journal of the American Medical Association</i>. 2015. 313(16):1627-35.",
            "subspecialties" : "Hematology;Pulmonology;Interventional Radiology",
            "expansion" : "Prevention du Risque d'Embolie Pulmonaire par Interruption Cave 2",
            "statusUsableDate" : "2015-07-01",
             "briefResultsDescription" : "IVC filters do not improve outcomes in acute high-risk PE",
             "published" : "2015-04-28",
             "pageName" : "PREPIC 2",
             "diseases" : "Venous Thromboembolism",
             "abbreviation" : "PREPIC 2",
             "title" : "Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial",
             "pmid" : "25919526"
         },
         },
         {
         {
             "timestamp" : "2017-01-19T19:36:24Z",
             "timestamp" : "2017-12-03T22:38:34Z",
             "briefDesignDescription" : "Early goal-directed therapy in sepsis",
             "briefDesignDescription" : "Rifapentine/isoniazid in latent TB",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010307",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1104875",
             "pageid" : 60,
             "pageid" : 928,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010307",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1104875",
             "trainingLevel" : "Student",
             "trainingLevel" : "fellow",
             "citation" : "Rivers E, <i>et al</i>. \"Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock\". <i>The New England Journal of Medicine</i>. 2001. 345(19):1368-1377.",
             "citation" : "Sterling TR, <i>et al</i>. \"Three months of rifapentine and isoniazid for latent tuberculosis infection.\". <i>The New England Journal of Medicine</i>. 2011. 365(23):2155-66.",
             "subspecialties" : "Critical Care;Emergency Medicine",
             "subspecialties" : "Infectious Disease",
             "expansion" : "",
             "expansion" : null,
             "briefResultsDescription" : "Early goal-directed therapy decreased mortality and morbiditiy in sepsis",
            "statusUsableDate" : "2012-08-01",
             "published" : "2001-11-08",
             "briefResultsDescription" : "Rifapentine/isoniazid x3 months is noninferior to isoniazid x9 months",
             "pageName" : "Rivers Trial",
            "published" : "2011-12-08",
             "diseases" : "Sepsis;Shock",
            "pageName" : "PREVENT TB",
             "abbreviation" : "",
            "diseases" : "Tuberculosis",
             "title" : "Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock",
            "abbreviation" : "PREVENT TB",
             "pmid" : "11794169"
            "title" : "Three months of rifapentine and isoniazid for latent tuberculosis infection.",
            "pmid" : "22150035"
        },
        {
            "timestamp" : "2017-12-03T22:38:46Z",
            "briefDesignDescription" : "EGDT in septic shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1401602",
            "pageid" : 1782,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1401602",
            "trainingLevel" : "Intern",
            "citation" : "Angus DC, <i>et al</i>. \"A randomized trial of protocol-based care for early septic shock\". <i>The New England Journal of Medicine</i>. 2014. 370(10):1683-1693.",
            "subspecialties" : "Critical Care",
            "expansion" : "Protocolized Care for Early Septic Shock",
            "statusUsableDate" : "2014-03-01",
            "briefResultsDescription" : "No difference for EGDT vs. standard protocol vs. usual care for septic shock",
             "published" : "2014-05-01",
             "pageName" : "ProCESS",
             "diseases" : "Sepsis",
             "abbreviation" : "ProCESS",
             "title" : "A randomized trial of protocol-based care for early septic shock",
             "pmid" : "24635773"
         },
         },
         {
         {
             "timestamp" : "2018-09-04T17:00:07Z",
             "timestamp" : "2017-12-03T22:38:35Z",
             "briefDesignDescription" : "Sertraline for depression post-ACS",
             "briefDesignDescription" : "FOLFIRINOX in pancreatic cancer",
             "fulltexturl" : "http://jama.ama-assn.org/content/288/6/701.full",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011923",
             "pageid" : 423,
             "pageid" : 2819,
             "pdfurl" : "http://jama.ama-assn.org/content/288/6/701.full.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011923",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Glassman AH, <i>et al</i>. \"Sertraline treatment of major depression in patients with acute MI or unstable angina\". <i>Journal of the American Medical Association</i>. 2002. 288(6):701-709.",
             "citation" : "Conroy T, <i>et al</i>. \"FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer\". <i>The New England Journal of Medicine</i>. 2011. 364(19):1817-1825.",
             "subspecialties" : "Psychiatry;Cardiology",
             "subspecialties" : "Oncology",
             "expansion" : "Sertraline Antidepressant Heart Attack Randomized Trial",
             "expansion" : "PRODIGE 4 Actions concertées dans les Cancers COloRectaux et Digestifs",
             "briefResultsDescription" : "Sertraline improves symptoms without adverse CV effects",
            "statusUsableDate" : "2016-09-01",
             "published" : "2002-08-14",
             "briefResultsDescription" : "FOLFIRINOX improves OS in metastatic pancreatic cancer compared to gemcitabine",
             "pageName" : "SADHART",
             "published" : "2011-05-12",
             "diseases" : "Depression;Acute Coronary Syndrome",
             "pageName" : "PRODIGE 4 ACCORD 11",
             "abbreviation" : "SADHAT",
             "diseases" : "Pancreatic Cancer",
             "title" : "Sertraline treatment of major depression in patients with acute MI or unstable angina",
             "abbreviation" : "PRODIGE 4 ACCORD 11",
             "pmid" : "12169073"
             "title" : "FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer",
             "pmid" : "21561347"
         },
         },
         {
         {
             "timestamp" : "2017-01-19T20:07:27Z",
             "timestamp" : "2017-12-03T22:38:44Z",
             "briefDesignDescription" : "Albumin vs. saline in ICU",
             "briefDesignDescription" : "ASA-dipyridamole vs. clopidogrel in stroke",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040232",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805002",
             "pageid" : 285,
             "pageid" : 1082,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040232",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805002",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Finfer S, <i>et al</i>. \"A comparison of albumin and saline for fluid resuscitation in the intensive care unit\". <i>The New England Journal of Medicine</i>. 2004. 350(22):2247-2256.",
             "citation" : "Sacco RL, <i>et al</i>. \"Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke\". <i>The New England Journal of Medicine</i>. 2008. 359(12):1238-1251.",
             "subspecialties" : "Critical Care",
             "subspecialties" : "Neurology",
             "expansion" : "Saline versus Albumin Fluid Evaluation",
             "expansion" : "Prevention Regimen for Effectively Avoiding Second Strokes",
             "briefResultsDescription" : "No mortality difference (except worse mortality with albumin for TBI)",
            "statusUsableDate" : "2012-11-01",
             "published" : "2004-05-27",
             "briefResultsDescription" : "Similar efficacy but less bleeding with clopidogrel",
             "pageName" : "SAFE",
            "published" : "2008-09-18",
             "diseases" : "Critical Illness",
            "pageName" : "PRoFESS",
             "abbreviation" : "SAFE",
            "diseases" : "Stroke",
             "title" : "A comparison of albumin and saline for fluid resuscitation in the intensive care unit",
            "abbreviation" : "PROFESS",
             "pmid" : "15163774"
            "title" : "Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke",
            "pmid" : "18753638"
        },
        {
            "timestamp" : "2017-12-03T22:38:37Z",
            "briefDesignDescription" : "D-Dimer testing after VTE",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa054444",
            "pageid" : 2967,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa054444",
            "trainingLevel" : "Resident",
            "citation" : "Palareti G, <i>et al</i>. \"d-Dimer Testing to Determine the Duration of Anticoagulation Therapy\". <i>The New England Journal of Medicine</i>. 2006. 355(17):1780-1789.",
            "subspecialties" : "Hematology",
            "expansion" : "",
            "statusUsableDate" : "2017-10-01",
            "briefResultsDescription" : "Abnormal D-dimer predicts VTE recurrence",
             "published" : "2006-10-26",
             "pageName" : "PROLONG",
             "diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
             "abbreviation" : "PROLONG",
             "title" : "d-Dimer Testing to Determine the Duration of Anticoagulation Therapy",
             "pmid" : "17065639"
         },
         },
         {
         {
             "timestamp" : "2018-04-05T18:17:47Z",
             "timestamp" : "2017-08-06T02:15:05Z",
             "briefDesignDescription" : "Balanced crystalloids vs. NS in non-critical ED patients",
             "briefDesignDescription" : "Procalcitonin-guided antibiotics",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711586",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61879-1/fulltext",
             "pageid" : 3556,
             "pageid" : 434,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711586",
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673609618791.pdf",
             "trainingLevel" : "Student",
             "trainingLevel" : "resident",
             "citation" : "Self WH, <i>et al</i>. \"Balanced crystalloids versus saline in noncritically ill adults\". <i>The New England Journal of Medicine</i>. 2018. 378(10):819-828.",
             "citation" : "Bouadma L, <i>et al</i>. \"Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units\". <i>The Lancet</i>. 2010. 375(9713):463-74.",
             "subspecialties" : "Critical Care;Nephrology",
             "subspecialties" : "Critical Care;Infectious Disease",
             "expansion" : "Saline Against Lactated Ringer's or Plasma-Lyte in the Emergency Department",
             "expansion" : "Procalcitonin to Reduce Antibiotic Treatments in Acutely ill patients",
             "briefResultsDescription" : "Balanced crystalloids result in fewer renal abnormalities",
            "statusUsableDate" : "2012-03-01",
             "published" : "2018-03-01",
             "briefResultsDescription" : "Procalcitonin noninferior and led to fewer days on antibiotics",
             "pageName" : "SALT-ED",
             "published" : "2010-02-06",
             "diseases" : "Hypovolemia;Acute Kidney Injury",
             "pageName" : "PRORATA",
             "abbreviation" : "SALT-ED",
             "diseases" : "Critical Illness",
             "title" : "Balanced crystalloids versus saline in noncritically ill adults",
             "abbreviation" : "PRORATA",
             "pmid" : "29485926"
             "title" : "Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units",
             "pmid" : "20097417"
         },
         },
         {
         {
             "timestamp" : "2015-08-24T04:52:18Z",
             "timestamp" : "2017-12-03T22:38:38Z",
             "briefDesignDescription" : "Captopril in MI with LV dysfunction",
             "briefDesignDescription" : "Prone ventilation in ARDS",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199209033271001",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1214103",
             "pageid" : 150,
             "pageid" : 1479,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199209033271001",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214103",
             "trainingLevel" : "Resident",
             "trainingLevel" : "fellow",
             "citation" : "Pfeffer MA, <i>et al</i>. \"Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial\". <i>The New England Journal of Medicine</i>. 1992. 327(10):669-677.",
             "citation" : "Guérin C, <i>et al</i>. \"Prone positioning in severe acute respiratory distress syndrome\". <i>The New England Journal of Medicine</i>. 2013. 368(23):2159-2168.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Critical Care",
             "expansion" : "Survival and Ventricular Enlargement Trial",
             "expansion" : "Proning Severe ARDS Patients",
             "briefResultsDescription" : "Captopril improves survival",
            "statusUsableDate" : "2013-06-01",
             "published" : "1992-09-03",
             "briefResultsDescription" : "Intermittent prone positioning improves survival in severe ARDS",
             "pageName" : "SAVE",
             "published" : "2013-06-06",
             "diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Heart Failure",
             "pageName" : "PROSEVA",
             "abbreviation" : "SAVE",
             "diseases" : "Acute Respiratory Distress Syndrome",
             "title" : "Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial",
             "abbreviation" : "PROSEVA",
             "pmid" : "1386652"
             "title" : "Prone positioning in severe acute respiratory distress syndrome",
             "pmid" : "23688302"
         },
         },
         {
         {
             "timestamp" : "2014-06-13T06:22:51Z",
             "timestamp" : "2018-01-22T20:17:30Z",
             "briefDesignDescription" : "Amiodarone or ICD in severe HFrEF",
             "briefDesignDescription" : "LAA closure vs. warfarin in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa043399",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61343-X/fulltext",
             "pageid" : 40,
             "pageid" : 2459,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043399",
             "pdfurl" : "",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Bardy GH, <i>et al</i>. \"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure\". <i>The New England Journal of Medicine</i>. 2005. 252(3):225-37.",
             "citation" : "Holmes DR, <i>et al</i>. \"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial\". <i>Lancet</i>. 2009. 374(9689):534-42.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Sudden Cardiac Death in Heart Failure Trial",
             "expansion" : "WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation",
             "briefResultsDescription" : "ICD reduces mortality by 23% in class II-III HFrEF",
            "statusUsableDate" : "2018-01-18",
             "published" : "2005-01-20",
             "briefResultsDescription" : "LAA closure was noninferior to warfarin therapy",
             "pageName" : "SCD-HeFT",
             "published" : "2009-11-07",
             "diseases" : "Heart Failure",
             "pageName" : "PROTECT AF",
             "abbreviation" : "SCD-HeFT",
             "diseases" : "Atrial Fibrillation;Stroke",
             "title" : "Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure",
             "abbreviation" : "PROTECT AF",
             "pmid" : "15659722"
             "title" : "Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial",
             "pmid" : "19683639"
         },
         },
         {
         {
             "timestamp" : "2018-04-05T17:39:53Z",
             "timestamp" : "2017-12-14T19:39:45Z",
             "briefDesignDescription" : "NS vs. balanced crystalloids in ICU",
             "briefDesignDescription" : "Pravastatin vs. atorvastatin after ACS",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711584",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040583",
             "pageid" : 3555,
             "pageid" : 1338,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711584",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040583",
             "trainingLevel" : "student",
             "trainingLevel" : "Intern",
             "citation" : "Semler MW, <i>et al</i>. \"Balanced Crystalloids versus Saline in Critically Ill Adults\". <i>The New England Journal of Medicine</i>. 2018. 378(9):829-839.",
             "citation" : "Cannon CP, <i>et al</i>. \"Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2004. 350(15):1495-1504.",
             "subspecialties" : "Critical Care;Nephrology",
             "subspecialties" : "Cardiology",
             "expansion" : "Isotonic Solutions and Major Adverse Renal Events Trial",
             "expansion" : "Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22",
             "briefResultsDescription" : "Balanced crystalloids slightly reduced composite rate of death, RRT, or CKD",
            "statusUsableDate" : "2013-04-01",
             "published" : "2018-03-01",
             "briefResultsDescription" : "High-dose atorvastatin is superior to moderate-dose pravastatin at reducing CV events after ACS",
             "pageName" : "SMART-MED and SMART-SURG",
             "published" : "2004-04-08",
             "diseases" : "Critical Illness",
             "pageName" : "PROVE IT-TIMI 22",
             "abbreviation" : "SMART",
             "diseases" : "Acute Coronary Syndrome;Hyperlipidemia",
             "title" : "Balanced Crystalloids versus Saline in Critically Ill Adults",
             "abbreviation" : "PROVE IT-TIMI 22",
             "pmid" : "29485925"
             "title" : "Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes",
             "pmid" : "15007110"
         },
         },
         {
         {
             "timestamp" : "2017-01-19T19:50:29Z",
             "timestamp" : "2017-12-03T22:38:41Z",
             "briefDesignDescription" : "Dopamine vs. norepinephrine in shock",
             "briefDesignDescription" : "Activated protein C in severe sepsis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907118",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200103083441001",
             "pageid" : 113,
             "pageid" : 983,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907118",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200103083441001",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "De Backer D, <i>et al</i>. \"Comparison of dopamine and norepinephrine in the treatment of shock\". <i>The New England Journal of Medicine</i>. 2010. 362(9):779-89.",
             "citation" : "Bernard GR, <i>et al</i>. \"Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis\". <i>The New England Journal of Medicine</i>. 2001. 344(10):699-709.",
             "subspecialties" : "Critical Care;Emergency Medicine",
             "subspecialties" : "Critical Care",
             "expansion" : "Sepsis Occurrence in Acutely Ill Patients II",
             "expansion" : "Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis",
             "briefResultsDescription" : "Norepinephrine reduces mortality",
            "statusUsableDate" : "2012-09-01",
             "published" : "2010-03-04",
             "briefResultsDescription" : "Improved survival with APC but not seen in subsequent larger PROWESS-SHOCK trial",
             "pageName" : "SOAP II",
             "published" : "2001-03-08",
             "pageName" : "PROWESS",
             "diseases" : "Sepsis;Shock",
             "diseases" : "Sepsis;Shock",
             "abbreviation" : "SOAP II",
             "abbreviation" : "PROWESS",
             "title" : "Comparison of dopamine and norepinephrine in the treatment of shock",
             "title" : "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis",
             "pmid" : "20200382"
             "pmid" : "11236773"
         },
         },
         {
         {
             "timestamp" : "2018-08-30T18:21:05Z",
             "timestamp" : "2017-12-03T22:38:43Z",
             "briefDesignDescription" : "Occult cancer screening in unprovoked VTE",
             "briefDesignDescription" : "Activated protein C in septic shock",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506623",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1202290",
             "pageid" : 2498,
             "pageid" : 977,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506623",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1202290",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Carrier M, <i>et al</i>. \"Screening for Occult Cancer in Unprovoked Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2015. 373(8):697-704.",
             "citation" : "Ranieri VM, <i>et al</i>. \"Drotrecogin Alfa (Activated) in Adults with Septic Shock\". <i>The New England Journal of Medicine</i>. 2012. 366(22):2055-2064.",
             "subspecialties" : "Oncology;Hematology",
             "subspecialties" : "Critical Care",
             "expansion" : "",
             "expansion" : "Prospective Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis and Septic Shock",
             "briefResultsDescription" : "No benefit over age-appropriate screening",
            "statusUsableDate" : "2012-09-01",
             "published" : "2015-08-20",
             "briefResultsDescription" : "No survival benefit at 28 or 90 days, in contrast to PROWESS",
             "pageName" : "SOME",
             "published" : "2012-05-31",
             "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
             "pageName" : "PROWESS-SHOCK",
             "abbreviation" : "SOME",
             "diseases" : "Sepsis;Shock",
             "title" : "Screening for Occult Cancer in Unprovoked Venous Thromboembolism",
             "abbreviation" : "PROWESS-SHOCK",
             "pmid" : "26095467"
             "title" : "Drotrecogin Alfa (Activated) in Adults with Septic Shock",
             "pmid" : "22616830"
         },
         },
         {
         {
             "timestamp" : "2018-01-11T18:23:36Z",
             "timestamp" : "2018-06-14T20:42:56Z",
             "briefDesignDescription" : "BP targets in high-risk patients",
             "briefDesignDescription" : "Basal-bolus insulin in inpatients with DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1511939",
             "fulltexturl" : "http://bit.ly/29xvPia",
             "pageid" : 2487,
             "pageid" : 2720,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1511939",
             "pdfurl" : "http://care.diabetesjournals.org/content/30/9/2181.full-text.pdf",
             "trainingLevel" : "Student",
             "trainingLevel" : "Intern",
             "citation" : "The SPRINT Research Group. \"A randomized trial of intensive versus standard blood-pressure control\". <i>The New England Journal of Medicine</i>. 2015. 373(22):2103-2116.",
             "citation" : "Umpierrez GE, <i>et al</i>. \"Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)\". <i>Diabetes Care</i>. 2007. 30(9):2181-2186.",
             "subspecialties" : "Cardiology;Preventive Medicine",
             "subspecialties" : "Critical care;Endocrinology",
             "expansion" : "Systolic Blood Pressure Intervention Trial",
             "expansion" : "Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes",
             "briefResultsDescription" : "SBP <120 improves CV outcomes with increased risks",
            "statusUsableDate" : "2018-06-14",
             "published" : "2015-11-09",
             "briefResultsDescription" : "Basal-bolus more effective for glycemic control compared to sliding-scale insulin",
             "pageName" : "SPRINT",
             "published" : "2007-09-30",
             "diseases" : "Hypertension",
             "pageName" : "RABBIT 2",
             "abbreviation" : "SPRINT",
             "diseases" : "Diabetes Mellitus",
             "title" : "A randomized trial of intensive versus standard blood-pressure control",
             "abbreviation" : "RABBIT 2",
             "pmid" : "26551272"
             "title" : "Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)",
             "pmid" : "17513708"
         },
         },
         {
         {
             "timestamp" : "2018-06-29T18:11:38Z",
             "timestamp" : "2014-05-22T00:30:05Z",
             "briefDesignDescription" : "Renal denervation in resistant hypertension",
             "briefDesignDescription" : "Lenient vs. strict rate control in AF",
             "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30951-6/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1001337",
             "pageid" : 3642,
             "pageid" : 181,
             "pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(18)30951-6.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001337",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Kandazi DE, <i>et al</i>. \"Effect of renal denervation on blood pressure in the presence of antihypertensive drugs\". <i>The Lancet</i>. 2018. 391:2346-55.",
             "citation" : "Van Gelder IC, <i>et al</i>. \"Lenient versus Strict Rate Control in Patients with Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2010. 362(15):1363-73.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy",
             "expansion" : "Rate Control Efficacy in Permanent Atrial Fibrillation: a Comparison between Lenient versus Strict Rate Control II",
             "briefResultsDescription" : "Renal denervation+meds is superior to medical therapy alone in resistant hypertension",
            "statusUsableDate" : "2012-03-01",
             "published" : "2018-06-09",
             "briefResultsDescription" : "Lenient rate control is as effective as strict rate control",
             "pageName" : "SPYRAL HTN-ON MED",
             "published" : "2010-04-15",
             "diseases" : "Hypertension",
             "pageName" : "RACE II",
             "abbreviation" : "SPYRAL HTN-ON MED",
             "diseases" : "Atrial Fibrillation",
             "title" : "Effect of renal denervation on blood pressure in the presence of antihypertensive drugs",
             "abbreviation" : "RACE II",
             "pmid" : "29803589"
             "title" : "Lenient versus Strict Rate Control in Patients with Atrial Fibrillation",
             "pmid" : "20231232"
         },
         },
         {
         {
             "timestamp" : "2013-03-05T21:40:49Z",
             "timestamp" : "2017-12-03T22:38:47Z",
             "briefDesignDescription" : "Symptom-triggered therapy in alcohol withdrawal",
             "briefDesignDescription" : "CRT+ICD for mild-moderate HFrEF",
             "fulltexturl" : "http://archinte.ama-assn.org/cgi/content/full/162/10/1117",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009540",
             "pageid" : 116,
             "pageid" : 2731,
             "pdfurl" : "http://archinte.ama-assn.org/cgi/reprint/162/10/1117.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009540",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Daeppen JB, <i>et al</i>. \"Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial\". <i>Archives of Internal Medicine</i>. 2002. 162(10):1117-21.",
             "citation" : "Tang AS, <i>et al</i>. \"Cardiac-resynchronization therapy for mild-to-moderate heart failure\". <i>The New England Journal of Medicine</i>. 2010. 363(25):2385-2395.",
             "subspecialties" : "Psychiatry",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Resynchronization–Defibrillation for Ambulatory Heart Failure",
             "briefResultsDescription" : "Symptom-triggered therapy reduces length of hospitalization without increasing adverse event risk",
            "statusUsableDate" : "2016-09-01",
             "published" : "2002-05-27",
             "briefResultsDescription" : "CRT+ICD reduces mortality but increased the rate of adverse events",
             "pageName" : "Symptom-Triggered Benzodiazepines in Alcohol Withdrawal",
             "published" : "2010-12-16",
             "diseases" : "Alcohol Withdrawal",
             "pageName" : "RAFT",
             "abbreviation" : "",
             "diseases" : "Heart Failure",
             "title" : "Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial",
             "abbreviation" : "RAFT",
             "pmid" : "12020181"
             "title" : "Cardiac-resynchronization therapy for mild-to-moderate heart failure",
             "pmid" : "21073365"
         },
         },
         {
         {
             "timestamp" : "2018-05-31T17:40:44Z",
             "timestamp" : "2015-08-24T04:40:44Z",
             "briefDesignDescription" : "Early vs. delayed invasive intervention in NSTEMI and UA",
             "briefDesignDescription" : "Spironolactone in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807986",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199909023411001",
             "pageid" : 2867,
             "pageid" : 11,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807986",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199909023411001",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Mehta SR, <i>et al</i>. \"Early versus Delayed Invasive Intervention in Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2009. 360:2165-2175.",
             "citation" : "Pitt B, <i>et al</i>. \"The effect of spironolactone on morbidity and mortality in patients with severe heart failure\". <i>New England Journal of Medicine</i>. 1999. 341(10):709-717.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "The Timing of Intervention in Acute Coronary Syndromes",
             "expansion" : "Randomized Aldactone Evaluation Study",
             "briefResultsDescription" : "Early intervention does not differ greatly from delayed intervention in low- to moderate-risk patients",
            "statusUsableDate" : "2012-03-01",
             "published" : "2009-05-21",
            "briefResultsDescription" : "Spironolactone reduces all-cause mortality by 30% in severe HFrEF",
             "pageName" : "TIMACS",
            "published" : "1999-09-02",
             "diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
            "pageName" : "RALES",
             "abbreviation" : "TIMACS",
            "diseases" : "Heart Failure",
             "title" : "Early versus Delayed Invasive Intervention in Acute Coronary Syndromes",
            "abbreviation" : "RALES",
             "pmid" : "19458363"
            "title" : "The effect of spironolactone on morbidity and mortality in patients with severe heart failure",
            "pmid" : "10471456"
        },
        {
            "timestamp" : "2017-12-03T22:38:49Z",
            "briefDesignDescription" : "Rituximab vs. cyclophosphamide in ANCA-associated vasculitis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909905",
            "pageid" : 1214,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909905",
            "trainingLevel" : "Fellow",
            "citation" : "Stone JH, <i>et al</i>. \"Rituximab versus cyclophosphamide for ANCA-associated vasculitis\". <i>The New England Journal of Medicine</i>. 2010. 363(3):221-232.",
            "subspecialties" : "Rheumatology",
            "expansion" : "Rituximab in ANCA-Associated Vasculitis",
            "statusUsableDate" : "2013-02-01",
             "briefResultsDescription" : "Rituximab noninferior to cyclophosphamide in ANCA-associated vasculitis",
            "published" : "2010-07-15",
            "pageName" : "RAVE",
            "diseases" : "Vasculitis",
            "abbreviation" : "RAVE",
            "title" : "Rituximab versus cyclophosphamide for ANCA-associated vasculitis",
            "pmid" : "20647199"
        },
        {
            "timestamp" : "2017-12-03T22:38:51Z",
            "briefDesignDescription" : "Dabigatran in mechanical heart valves",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300615",
            "pageid" : 1707,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300615",
            "trainingLevel" : "Resident",
            "citation" : "Eikelboom JW, <i>et al</i>. \"Dabigatran versus warfarin in patients with mechanical heart valves\". <i>The New England Journal of Medicine</i>. 2013. 369(13):1206-1214.",
            "subspecialties" : "Cardiology;Hematology",
            "expansion" : "Randomized, Phase II Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients after Heart Valve Replacement",
            "statusUsableDate" : "2013-10-01",
            "briefResultsDescription" : "Dabigatran has more thromboembolism and bleeding than warfarin",
             "published" : "2013-09-26",
             "pageName" : "RE-ALIGN",
             "diseases" : "Valvular Disease",
             "abbreviation" : "RE-ALIGN",
             "title" : "Dabigatran versus warfarin in patients with mechanical heart valves",
             "pmid" : "23991661"
         },
         },
         {
         {
             "timestamp" : "2017-12-14T19:37:07Z",
             "timestamp" : "2017-12-03T22:38:52Z",
             "briefDesignDescription" : "Atorvastatin in stable CAD",
             "briefDesignDescription" : "Dabigatran vs. warfarin in VTE",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa050461",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906598",
             "pageid" : 1762,
             "pageid" : 973,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa050461",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906598",
             "trainingLevel" : "Student",
             "trainingLevel" : "fellow",
             "citation" : "LaRosa JC, <i>et al</i>. \"Intensive lipid lowering with atorvastatin in patients with stable coronary disease\". <i>The New England Journal of Medicine</i>. 2005. 352(14):1425-1435.",
             "citation" : "Schulman S, <i>et al</i>. \"Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism\". <i>New England Journal of Medicine</i>. 2009. 361(24):2342-52.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Hematology;Pulmonology",
             "expansion" : "Treating to New Targets",
             "expansion" : "Efficacy and Safety of Dabigatran Compared to Warfarin for 6 Month Treatment of Acute Symptomatic Venous Thromboembolism",
             "briefResultsDescription" : "Atorvastatin 80 mg better than 10 mg for major CV events in stable CAD",
            "statusUsableDate" : "2012-08-01",
             "published" : "2005-04-07",
             "briefResultsDescription" : "Dabigatran non-inferior to warfarin for VTE recurrence, but dabigatran yielded less bleeding",
             "pageName" : "TNT",
             "published" : "2009-12-10",
             "diseases" : "Coronary Artery Disease;Hyperlipidemia",
             "pageName" : "RE-COVER",
             "abbreviation" : "TNT",
             "diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
             "title" : "Intensive lipid lowering with atorvastatin in patients with stable coronary disease",
             "abbreviation" : "RE-COVER",
             "pmid" : "15755765"
             "title" : "Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism",
             "pmid" : "19966341"
         },
         },
         {
         {
             "timestamp" : "2017-12-14T19:36:29Z",
             "timestamp" : "2018-01-30T17:09:14Z",
             "briefDesignDescription" : "Na reduction and weight loss for HTN control in elderly",
             "briefDesignDescription" : "Triple therapy vs. ASA+dabigatran in PCI if AF",
             "fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/vol/279/pg/839",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1708454",
             "pageid" : 2990,
             "pageid" : 3527,
             "pdfurl" : "",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1708454",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Whelton PK, <i>et al</i>. \"Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group\". <i>JAMA</i>. 1998. 279(11):839-846.",
             "citation" : "Cannon CP, <i>et al</i>. \"Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2017. 377(16):1513-1524.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Trial of Nonpharmacologic Interventions in the Elderly",
             "expansion" : "Randomized evaluation of dual antithrombotic therapy with dabigatran versus triple therapy with warfarin in patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention",
             "briefResultsDescription" : "Na reduction and weight loss are effective means for hypertension control in the elderly",
            "statusUsableDate" : "2018-01-29",
             "published" : "1998-03-18",
             "briefResultsDescription" : "Aspirin and dabigatran nonferior to triple therapy in patients with AF undergoing PCI",
             "pageName" : "TONE",
             "published" : "2017-10-19",
             "diseases" : "Hypertension",
             "pageName" : "RE-DUAL",
             "abbreviation" : "TONE",
             "diseases" : "Coronary Artery Disease",
             "title" : "Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group",
             "abbreviation" : "RE-DUAL PCI",
             "pmid" : "9515998"
             "title" : "Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation",
             "pmid" : "28844193"
         },
         },
         {
         {
             "timestamp" : "2015-05-29T16:40:40Z",
             "timestamp" : "2015-04-18T21:22:31Z",
             "briefDesignDescription" : "Salmeterol/fluticasone in COPD",
             "briefDesignDescription" : "Dabigatran vs. warfarin in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa063070",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0905561",
             "pageid" : 124,
             "pageid" : 178,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa063070",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0905561",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Calverley PM, <i>et al</i>. \"Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease\". <i>The New England Journal of Medicine</i>. 2007. 356(8):775-789.",
             "citation" : "Connolly SJ, <i>et al</i>. \"Dabigatran versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2009. 361(12):1139-51.",
             "subspecialties" : "Pulmonology",
             "subspecialties" : "Cardiology;Neurology",
             "expansion" : "Towards a Revolution in COPD Health",
             "expansion" : "Randomized Evaluation of Long-Term Anticoagulation Therapy",
             "briefResultsDescription" : "Trend towards mortality benefit",
            "statusUsableDate" : "2012-03-01",
             "published" : "2007-02-22",
             "briefResultsDescription" : "High-dose dabigatran reduces stroke risk without increasing major bleeding in atrial fibrillation",
             "pageName" : "TORCH",
             "published" : "2009-09-17",
             "diseases" : "Chronic Obstructive Pulmonary Disease",
             "pageName" : "RE-LY",
             "abbreviation" : "TORCH",
             "diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
             "title" : "Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease",
             "abbreviation" : "RE-LY",
             "pmid" : "17314337"
             "title" : "Dabigatran versus warfarin in patients with atrial fibrillation",
             "pmid" : "19717844"
         },
         },
         {
         {
             "timestamp" : "2018-10-18T17:42:04Z",
             "timestamp" : "2017-12-03T22:38:54Z",
             "briefDesignDescription" : "Rivaroxaban in high-risk APLS",
            "briefDesignDescription" : "Idarucizumab for dabigatran reversal",
             "fulltexturl" : "https://doi.org/10.1182/blood-2018-04-848333",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1502000",
             "pageid" : 3700,
            "pageid" : 2421,
            "pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1502000",
            "trainingLevel" : "Intern",
            "citation" : "Pollack CV, <i>et al</i>. \"Idarucizumab for Dabigatran Reversal\". <i>The New England Journal of Medicine</i>. 2015. 373(6):511-520.",
            "subspecialties" : "Hematology",
            "expansion" : "",
            "statusUsableDate" : "2016-01-01",
            "briefResultsDescription" : "Idarucizumab reversed the dabigatran effect in minutes",
            "published" : "2015-08-06",
            "pageName" : "RE-VERSE AD",
            "diseases" : "Hemorrhage",
            "abbreviation" : "RE-VERSE AD",
            "title" : "Idarucizumab for Dabigatran Reversal",
            "pmid" : "26095746"
        },
        {
            "timestamp" : "2017-12-03T22:38:55Z",
             "briefDesignDescription" : "Darbepoetin in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1214865",
            "pageid" : 1842,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214865",
            "trainingLevel" : "Fellow",
            "citation" : "Swedberg K, <i>et al</i>. \"Treatment of anemia with darbepoetin alfa in systolic heart failure\". <i>The New England Journal of Medicine</i>. 2013. 368(13):1210-9.",
            "subspecialties" : "Cardiology;Hematology",
            "expansion" : "Reduction of Events by Darbepoetin Alfa in Heart Failure",
            "statusUsableDate" : "2014-06-01",
            "briefResultsDescription" : "Darbepoetin does not improve clinical outcomes in HF with anemia",
            "published" : "2013-03-28",
            "pageName" : "RED-HF",
            "diseases" : "Heart Failure;Anemia",
            "abbreviation" : "RED-HF",
            "title" : "Treatment of anemia with darbepoetin alfa in systolic heart failure",
            "pmid" : "23473338"
        },
        {
            "timestamp" : "2017-12-03T22:38:56Z",
            "briefDesignDescription" : "5d vs. 14d steroids in acute COPD",
            "fulltexturl" : "http://bit.ly/1BQhpuy",
             "pageid" : 1615,
             "pdfurl" : null,
             "pdfurl" : null,
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Intern",
             "citation" : "Pengo V, <i>et al</i>. \"Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome\". <i>Blood</i>. 2018. 132(13):1365-1371.",
             "citation" : "Leuppi JD, <i>et al</i>. \"Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial\". <i>JAMA</i>. 2013. 309(21):2223-2231.",
             "subspecialties" : "Hematology;Rheumatology",
             "subspecialties" : "Pulmonology",
             "expansion" : "Trial on Rivaroxaban in AntiPhospholipid Syndrome",
             "expansion" : "Reduction in the Use of Corticosteroids in Exacerbated COPD",
             "briefResultsDescription" : "Rivaroxaban inferior to warfarin in high-risk APLS",
            "statusUsableDate" : "2013-09-01",
             "published" : "2018-09-27",
             "briefResultsDescription" : "5d steroids noninferior to 14d in acute COPD",
             "pageName" : "TRAPS",
             "published" : "2013-06-05",
             "diseases" : "Antiphospholipid Syndrome",
             "pageName" : "REDUCE",
             "abbreviation" : "TRAPS",
             "diseases" : "Chronic Obstructive Pulmonary Disease",
             "title" : "Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome",
             "abbreviation" : "REDUCE",
             "pmid" : "30002145"
             "title" : "Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial",
             "pmid" : "23695200"
         },
         },
         {
         {
             "timestamp" : "2015-03-09T17:49:43Z",
             "timestamp" : "2017-12-03T22:38:58Z",
             "briefDesignDescription" : "Darbepoetin in CKD and T2DM",
             "briefDesignDescription" : "Sildenafil vs. placebo in HFpEF",
             "fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907845",
             "fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/1663257",
             "pageid" : 5,
             "pageid" : 2973,
             "pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907845",
             "pdfurl" : "https://jamanetwork.com/journals/jama/articlepdf/1663257/joc130025_1268_1277.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Pfeffer MA, <i>et al</i>. \"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease\". <i>The New England Journal of Medicine</i>. 2009. 361(21):2019-32.",
             "citation" : "Redfield MM, <i>et al</i>. \"Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction\". <i>JAMA</i>. 2013. 309(12):1268-1277.",
             "subspecialties" : "Nephrology;Hematology;Endocrinology",
             "subspecialties" : "Cardiology",
             "expansion" : "Trial to Reduce Cardiovascular Events With Aranesp Therapy",
             "expansion" : "Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction",
             "briefResultsDescription" : "No mortality benefit when targeting higher hemoglobin with ESAs in patients with CKD and T2DM",
            "statusUsableDate" : "2017-10-01",
             "published" : "2009-11-19",
             "briefResultsDescription" : "Sildenafil not superior to placebo in HFpEF",
             "pageName" : "TREAT",
             "published" : "2013-03-11",
             "diseases" : "Chronic Kidney Disease;Anemia;Diabetes Mellitus",
             "pageName" : "RELAX",
             "abbreviation" : "TREAT",
             "diseases" : "Heart Failure",
             "title" : "A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease",
             "abbreviation" : "RELAX",
             "pmid" : "19880844"
             "title" : "Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction",
             "pmid" : "23478662"
         },
         },
         {
         {
             "timestamp" : "2017-01-19T20:08:09Z",
             "timestamp" : "2017-12-03T22:38:59Z",
             "briefDesignDescription" : "Transfusion thresholds in ICU",
             "briefDesignDescription" : "ARBs in diabetic nephropathy",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199902113400601",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011161",
             "pageid" : 104,
             "pageid" : 1030,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199902113400601",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011161",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Hebert PC, <i>et al</i>. \"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care\". <i>The New England Journal of Medicine</i>. 1999. 340(6):409-417.",
             "citation" : "Brenner BM, <i>et al</i>. \"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy\". <i>The New England Journal of Medicine</i>. 2001. 345(12):861-869.",
             "subspecialties" : "Critical Care;Hematology",
             "subspecialties" : "Endocrinology;Nephrology",
             "expansion" : "Transfusion Requirements in Critical Care",
             "expansion" : "Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan",
             "briefResultsDescription" : "Restrictive hemoglobin goals improved mortality",
            "statusUsableDate" : "2013-01-01",
             "published" : "1999-02-11",
             "briefResultsDescription" : "ARBs reduce progression to",
             "pageName" : "TRICC",
             "published" : "2001-09-20",
             "diseases" : "Anemia",
             "pageName" : "RENAAL",
             "abbreviation" : "TRICC",
             "diseases" : "Diabetes Mellitus;Chronic Kidney Disease",
             "title" : "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care",
             "abbreviation" : "RENAAL",
             "pmid" : "9971864"
             "title" : "Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy",
             "pmid" : "11565518"
         },
         },
         {
         {
             "timestamp" : "2018-04-26T17:40:38Z",
             "timestamp" : "2018-07-22T21:45:32Z",
             "briefDesignDescription" : "Transfusion thresholds for cardiac surgery",
             "briefDesignDescription" : "Craniectomy vs. medical care for intracranial hypertension",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711818",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1605215",
             "pageid" : 3536,
             "pageid" : 3596,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711818",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1605215",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Mazer CD, <i>et al</i>. \"Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery\". <i>The New England Journal of Medicine</i>. 2017. 377(22):2133-44.",
             "citation" : "Hutchinson PJ, <i>et al</i>. \"Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension\". <i>The New England Journal of Medicine</i>. 2016. 375(12):1119-30.",
             "subspecialties" : "Surgery;Hematology",
             "subspecialties" : "Surgery;Neurology",
             "expansion" : "Transfusion Requirements in Cardiac Surgery",
             "expansion" : "Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure",
             "briefResultsDescription" : "Restrictive noninferior to liberal RBC transfusions",
            "statusUsableDate" : "2018-07-19",
             "published" : "2017-11-30",
             "briefResultsDescription" : "Craniectomy reduced mortality by 22% compared to usual care",
             "pageName" : "TRICS III",
             "published" : "2016-09-22",
             "diseases" : "Anemia",
             "pageName" : "RESCUEicp",
             "abbreviation" : "TRICS III",
             "diseases" : "Intracranial Hypertension;Traumatic Brain Injury",
             "title" : "Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery",
             "abbreviation" : "RESCUEicp",
             "pmid" : "29130845"
             "title" : "Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension",
             "pmid" : "27602507"
         },
         },
         {
         {
             "timestamp" : "2018-09-11T23:25:53Z",
             "timestamp" : "2017-12-03T22:39:00Z",
             "briefDesignDescription" : "Intensive glycemic therapy in T2DM",
             "briefDesignDescription" : "PFO closure in cryptogenic stroke",
             "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140673698070196",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1301440",
             "pageid" : 253,
             "pageid" : 1334,
             "pdfurl" : "",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1301440",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Turner R, <i>et al</i>. \"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes\". <i>The Lancet</i>. 1998. 352(9131):837-53.",
             "citation" : "Carroll JD, <i>et al</i>. \"Closure of patent foramen ovale versus medical therapy after cryptogenic stroke\". <i>The New England Journal of Medicine</i>. 2013. 368(12):1092-1100.",
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Neurology;Cardiology",
             "expansion" : "United Kingdom Prospective Diabetes Study",
             "expansion" : "Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment",
             "briefResultsDescription" : "Reduction in microvascular complications",
            "statusUsableDate" : "2013-05-01",
             "published" : "1998-09-12",
             "briefResultsDescription" : "PFO closure does not reduce recurrent CVA after cryptogenic CVA",
             "pageName" : "UKPDS 33",
             "published" : "2013-03-21",
             "diseases" : "Diabetes Mellitus",
             "pageName" : "RESPECT",
             "abbreviation" : "UKPDS",
             "diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
             "title" : "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes",
             "abbreviation" : "RESPECT",
             "pmid" : "9742976"
             "title" : "Closure of patent foramen ovale versus medical therapy after cryptogenic stroke",
             "pmid" : "23514286"
         },
         },
         {
         {
             "timestamp" : "2012-10-29T23:28:48Z",
             "timestamp" : "2017-12-03T22:39:03Z",
             "briefDesignDescription" : "Tiotropium in COPD",
            "briefDesignDescription" : "Rifaximin/lactulose vs. lactulose for acute HE",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805800",
            "fulltexturl" : "http://www.nature.com/ajg/journal/v108/n9/full/ajg2013219a.html",
             "pageid" : 123,
            "pageid" : 1784,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805800",
            "pdfurl" : "http://www.nature.com/ajg/journal/v108/n9/pdf/ajg2013219a.pdf",
             "trainingLevel" : "Resident",
            "trainingLevel" : "Intern",
             "citation" : "Tashkin DP, <i>et al</i>. \"A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease\". <i>The New England Journal of Medicine</i>. 2008. 395(15):1543-1554.",
            "citation" : "Sharma BC, <i>et al</i>. \"A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy\". <i>The American Journal of Gastroenterology</i>. 2013. 108(9):1458-1463.",
             "subspecialties" : "Pulmonology",
            "subspecialties" : "Gastroenterology",
             "expansion" : "Understanding Potential Long-Term Impacts on Function with Tiotropium",
            "expansion" : "",
             "briefResultsDescription" : "Decreased exacerbations and mortality",
            "statusUsableDate" : "2014-03-01",
             "published" : "2008-10-09",
            "briefResultsDescription" : "Rifaximin/lactulose improved rates of HE reversal and survival, reduced hospital LOS",
             "pageName" : "UPLIFT",
            "published" : "2013-09-01",
             "diseases" : "Chronic Obstructive Pulmonary Disease",
            "pageName" : "Rifaximin and Lactulose for HE",
             "abbreviation" : "UPLIFT",
            "diseases" : "Hepatic Encephalopathy",
             "title" : "A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease",
            "abbreviation" : "",
             "pmid" : "18836213"
            "title" : "A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy",
            "pmid" : "23877348"
        },
        {
            "timestamp" : "2017-01-19T19:36:24Z",
             "briefDesignDescription" : "Early goal-directed therapy in sepsis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010307",
             "pageid" : 60,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010307",
             "trainingLevel" : "Student",
             "citation" : "Rivers E, <i>et al</i>. \"Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock\". <i>The New England Journal of Medicine</i>. 2001. 345(19):1368-1377.",
             "subspecialties" : "Critical Care;Emergency Medicine",
             "expansion" : "",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Early goal-directed therapy decreased mortality and morbiditiy in sepsis",
             "published" : "2001-11-08",
             "pageName" : "Rivers Trial",
             "diseases" : "Sepsis;Shock",
             "abbreviation" : "",
             "title" : "Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock",
             "pmid" : "11794169"
         },
         },
         {
         {
             "timestamp" : "2014-09-24T22:23:54Z",
             "timestamp" : "2017-12-03T22:39:02Z",
             "briefDesignDescription" : "Aspirin in unstable angina",
             "briefDesignDescription" : "Rivaroxaban vs. warfarin in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198308183090703",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009638",
             "pageid" : 261,
             "pageid" : 1358,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198308183090703",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009638",
            "trainingLevel" : "Student",
            "citation" : "Patel MR, <i>et al</i>. \"Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2011. 365(10):883-891.",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation",
            "statusUsableDate" : "2013-04-01",
            "briefResultsDescription" : "Rivaroxaban is noninferior to warfarin for stroke/embolization prevention in nonvalvular AF",
            "published" : "2011-09-08",
            "pageName" : "ROCKET AF",
            "diseases" : "Atrial Fibrillation;Stroke;Transient Ischemic Attack",
            "abbreviation" : "ROCKET AF",
            "title" : "Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation",
            "pmid" : "21830957"
        },
        {
            "timestamp" : "2018-09-04T17:00:07Z",
            "briefDesignDescription" : "Sertraline for depression post-ACS",
            "fulltexturl" : "http://jama.ama-assn.org/content/288/6/701.full",
            "pageid" : 423,
            "pdfurl" : "http://jama.ama-assn.org/content/288/6/701.full.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Lewis HD, <i>et al</i>. \"Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study\". <i>The New England Journal of Medicine</i>. 1983. 309(7):396-403.",
             "citation" : "Glassman AH, <i>et al</i>. \"Sertraline treatment of major depression in patients with acute MI or unstable angina\". <i>Journal of the American Medical Association</i>. 2002. 288(6):701-709.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Psychiatry;Cardiology",
             "expansion" : null,
             "expansion" : "Sertraline Antidepressant Heart Attack Randomized Trial",
             "briefResultsDescription" : "Aspirin decreases mortality",
            "statusUsableDate" : "2012-05-01",
             "published" : "1983-08-18",
             "briefResultsDescription" : "Sertraline improves symptoms without adverse CV effects",
             "pageName" : "VA Cooperative Study",
             "published" : "2002-08-14",
             "diseases" : "Acute Coronary Syndrome",
             "pageName" : "SADHART",
             "abbreviation" : null,
             "diseases" : "Depression;Acute Coronary Syndrome",
             "title" : "Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study",
             "abbreviation" : "SADHAT",
             "pmid" : "6135989"
             "title" : "Sertraline treatment of major depression in patients with acute MI or unstable angina",
             "pmid" : "12169073"
         },
         },
         {
         {
             "timestamp" : "2018-01-11T18:14:18Z",
             "timestamp" : "2017-01-19T20:07:27Z",
             "briefDesignDescription" : "ACE+ARB in DM nephropathy",
             "briefDesignDescription" : "Albumin vs. saline in ICU",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1303154",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa040232",
             "pageid" : 1798,
             "pageid" : 285,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1303154",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa040232",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Fried LF, <i>et al</i>. \"Combined angiotensin inhibition for the treatment of diabetic nephropathy\". <i>The New England Journal of Medicine</i>. 2013. 369(20):1892-1903.",
             "citation" : "Finfer S, <i>et al</i>. \"A comparison of albumin and saline for fluid resuscitation in the intensive care unit\". <i>The New England Journal of Medicine</i>. 2004. 350(22):2247-2256.",
             "subspecialties" : "Nephrology;Endocrinology",
             "subspecialties" : "Critical Care",
             "expansion" : "Veterans Affairs Nephropathy in Diabetes",
             "expansion" : "Saline versus Albumin Fluid Evaluation",
             "briefResultsDescription" : "ACE+ARB no more effective than monotherapy, increases complications",
            "statusUsableDate" : "2012-03-01",
             "published" : "2013-11-14",
             "briefResultsDescription" : "No mortality difference (except worse mortality with albumin for TBI)",
             "pageName" : "VA-NEPHRON D",
             "published" : "2004-05-27",
             "diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
             "pageName" : "SAFE",
             "abbreviation" : "VA NEPHRON-D",
             "diseases" : "Critical Illness",
             "title" : "Combined angiotensin inhibition for the treatment of diabetic nephropathy",
             "abbreviation" : "SAFE",
             "pmid" : "24206457"
             "title" : "A comparison of albumin and saline for fluid resuscitation in the intensive care unit",
             "pmid" : "15163774"
         },
         },
         {
         {
             "timestamp" : "2018-08-12T16:18:00Z",
             "timestamp" : "2018-04-05T18:17:47Z",
             "briefDesignDescription" : "Intensive glycemic therapy in T2DM",
             "briefDesignDescription" : "Balanced crystalloids vs. NS in non-critical ED patients",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0808431",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711586",
             "pageid" : 254,
             "pageid" : 3556,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0808431",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711586",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Duckworth W, <i>et al</i>. \"Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2009. 360(2):129-39.",
             "citation" : "Self WH, <i>et al</i>. \"Balanced crystalloids versus saline in noncritically ill adults\". <i>The New England Journal of Medicine</i>. 2018. 378(10):819-828.",
             "subspecialties" : "Endocrinology",
            "subspecialties" : "Critical Care;Nephrology",
             "expansion" : "Veterans Affairs Diabetes Trial",
            "expansion" : "Saline Against Lactated Ringer's or Plasma-Lyte in the Emergency Department",
             "briefResultsDescription" : "No effect on macrovascular or severe microvascular outcomes",
            "statusUsableDate" : "2018-04-05",
             "published" : "2009-01-08",
            "briefResultsDescription" : "Balanced crystalloids result in fewer renal abnormalities",
             "pageName" : "VADT",
            "published" : "2018-03-01",
             "diseases" : "Diabetes Mellitus",
            "pageName" : "SALT-ED",
             "abbreviation" : "VADT",
            "diseases" : "Hypovolemia;Acute Kidney Injury",
             "title" : "Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes",
            "abbreviation" : "SALT-ED",
             "pmid" : "19092145"
            "title" : "Balanced crystalloids versus saline in noncritically ill adults",
            "pmid" : "29485926"
        },
        {
            "timestamp" : "2017-12-03T22:39:06Z",
            "briefDesignDescription" : "Stenting in intracranial stenosis",
            "fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa1105335",
            "pageid" : 2420,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa1105335",
            "trainingLevel" : "Intern",
            "citation" : "Chimowitz MI, <i>et al</i>. \"Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis\". <i>The New England Journal of Medicine</i>. 2015. 365(11):993-1003.",
             "subspecialties" : "Neurology;Interventional Radiology",
             "expansion" : "",
            "statusUsableDate" : "2016-03-01",
             "briefResultsDescription" : "Medical therapy superior to stenting in IC stenosis",
             "published" : "2011-09-15",
             "pageName" : "SAMMPRIS",
             "diseases" : "Stroke",
             "abbreviation" : "SAMMPRIS",
             "title" : "Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis",
             "pmid" : "24168957"
         },
         },
         {
         {
             "timestamp" : "2014-08-24T17:55:57Z",
             "timestamp" : "2015-08-24T04:52:18Z",
             "briefDesignDescription" : "Valsartan in HFrEF",
             "briefDesignDescription" : "Captopril in MI with LV dysfunction",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010713",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199209033271001",
             "pageid" : 20,
             "pageid" : 150,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010713",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199209033271001",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Cohn JN, <i>et al</i>. \"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure\". <i>New England Journal of Medicine</i>. 2001. 345(23):1667-75.",
             "citation" : "Pfeffer MA, <i>et al</i>. \"Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial\". <i>The New England Journal of Medicine</i>. 1992. 327(10):669-677.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Valsartan Heart Failure Trial",
             "expansion" : "Survival and Ventricular Enlargement Trial",
             "briefResultsDescription" : "No mortality benefit of valsartan in NYHA II-IV HF",
            "statusUsableDate" : "2012-03-01",
             "published" : "2001-12-06",
            "briefResultsDescription" : "Captopril improves survival",
             "pageName" : "Val-HeFT",
            "published" : "1992-09-03",
            "pageName" : "SAVE",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Heart Failure",
            "abbreviation" : "SAVE",
            "title" : "Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction — Results of the Survival and Ventricular Enlargement Trial",
            "pmid" : "1386652"
        },
        {
            "timestamp" : "2014-06-13T06:22:51Z",
            "briefDesignDescription" : "Amiodarone or ICD in severe HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa043399",
            "pageid" : 40,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa043399",
            "trainingLevel" : "Intern",
            "citation" : "Bardy GH, <i>et al</i>. \"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure\". <i>The New England Journal of Medicine</i>. 2005. 252(3):225-37.",
            "subspecialties" : "Cardiology",
            "expansion" : "Sudden Cardiac Death in Heart Failure Trial",
            "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "ICD reduces mortality by 23% in class II-III HFrEF",
             "published" : "2005-01-20",
             "pageName" : "SCD-HeFT",
             "diseases" : "Heart Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "Val-HeFT",
             "abbreviation" : "SCD-HeFT",
             "title" : "A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure",
             "title" : "Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure",
             "pmid" : "11759645"
             "pmid" : "15659722"
         },
         },
         {
         {
             "timestamp" : "2015-07-05T22:55:54Z",
             "timestamp" : "2017-12-03T22:39:08Z",
             "briefDesignDescription" : "Valsartan vs. captopril in MI with LV dysfunction",
             "briefDesignDescription" : "Dexmedetomidine vs. midazolam for sedation",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa032292",
             "fulltexturl" : "http://jama.ama-assn.org/content/301/5/489.long",
             "pageid" : 462,
             "pageid" : 353,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa032292",
             "pdfurl" : "http://jama.ama-assn.org/content/301/5/489.full.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Pfeffer, MA <i>et al</i>. \"Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both\". <i>The New England Journal of Medicine</i>. 2003. 349(20):1893-1903.",
             "citation" : "Riker RR, <i>et al</i>. \"Dexmedetomidine vs. Midazolam for Sedation of Critically Ill Patients\". <i>Journal of American Medical Association</i>. 2009. 301(5):489-499.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Critical Care",
             "expansion" : "Valsartan in Acute Myocardial Infarction Trial",
             "expansion" : "Safety and Efficacy of Dexmedetomidine Compared with Midazolam",
             "briefResultsDescription" : "Valsartan as effective as captopril",
             "statusUsableDate" : "2012-04-01",
             "published" : "2003-11-13",
             "briefResultsDescription" : "↓ delirium, ↓ ventilator days with dexmedetomidine",
             "pageName" : "VALIANT",
            "published" : "2009-02-04",
             "diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
             "pageName" : "SEDCOM",
             "abbreviation" : "VALIANT",
             "diseases" : "Critical Illness",
             "title" : "Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both",
             "abbreviation" : "SEDCOM",
             "pmid" : "12921816"
             "title" : "Dexmedetomidine vs. Midazolam for Sedation of Critically Ill Patients",
            "pmid" : "19188334"
        },
        {
             "timestamp" : "2017-12-03T22:39:09Z",
            "briefDesignDescription" : "MAP 65-70 vs. 80-85 mmHg in sepsis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1312173",
            "pageid" : 1779,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1312173",
            "trainingLevel" : "Resident",
            "citation" : "Asfar P, <i>et al</i>. \"High versus low blood-pressure target in patients with septic shock\". <i>The New England Journal of Medicine</i>. 2014. 370(17):1583-1593.",
            "subspecialties" : "Critical Care",
            "expansion" : "Sepsis and Mean Arterial Pressure",
            "statusUsableDate" : "2014-04-01",
            "briefResultsDescription" : "No difference for higher MAP in sepsis except renal protection in vascular disease",
            "published" : "2014-04-23",
            "pageName" : "SEPSISPAM",
            "diseases" : "Sepsis;Shock",
            "abbreviation" : "SEPSISPAM",
            "title" : "High versus low blood-pressure target in patients with septic shock",
            "pmid" : "24635770"
        },
        {
            "timestamp" : "2017-12-03T22:39:10Z",
            "briefDesignDescription" : "Ivabradine in HFrEF",
            "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0140673610611981",
            "pageid" : 2735,
            "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(10)61198-1.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Swedberg K <i>et al</i>. \"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study\". <i>Lancet</i>. 2010. 376(10):875-885.",
            "subspecialties" : "Cardiology",
            "expansion" : "Systolic Heart failure treatment with the If inhibitor ivabradine Trial",
            "statusUsableDate" : "2016-05-01",
            "briefResultsDescription" : "Ivabradine improves mortality and heart failure hospitalization in HFrEF",
            "published" : "2010-09-11",
            "pageName" : "SHIFT",
            "diseases" : "Heart Failure",
            "abbreviation" : "SHIFT",
            "title" : "Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study",
            "pmid" : "20801500"
        },
        {
            "timestamp" : "2017-12-03T22:39:12Z",
            "briefDesignDescription" : "Early PCI/CABG in MI + shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199908263410901",
            "pageid" : 388,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199908263410901",
            "trainingLevel" : "Resident",
            "citation" : "Hochman JS, <i>et al</i>. \"Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock\". <i>The New England Journal of Medicine</i>. 1999. 341(9):625-634.",
            "subspecialties" : "Cardiology;Critical Care",
            "expansion" : "SHould we emergently revascularize Occluded Coronaries for Cardiogenic shocK",
            "statusUsableDate" : "2012-04-01",
            "briefResultsDescription" : "Early PCI/CABG improves survival in acute MI and cardiogenic shock",
            "published" : "1999-08-26",
            "pageName" : "SHOCK",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
            "abbreviation" : "SHOCK",
            "title" : "Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock",
            "pmid" : "10460813"
        },
        {
            "timestamp" : "2017-12-03T22:39:13Z",
            "briefDesignDescription" : "Salmeterol in asthma",
            "fulltexturl" : "http://bit.ly/1VSBfoL",
            "pageid" : 512,
            "pdfurl" : "http://journal.publications.chestnet.org/data/Journals/CHEST/22038/15.pdf",
            "trainingLevel" : "intern",
            "citation" : "Nelson HS, <i>et al</i>. \"The salmeterol multicenter asthma research trial\". <i>Chest</i>. 2006. 129(1):15-26.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Salmeterol Multicenter Asthma Research Trial",
            "statusUsableDate" : "2012-08-01",
            "briefResultsDescription" : "Salmeterol increases death in subgroups",
            "published" : "2006-01-01",
            "pageName" : "SMART",
            "diseases" : "Asthma",
            "abbreviation" : "SMART",
            "title" : "The salmeterol multicenter asthma research trial",
            "pmid" : "16424409"
        },
        {
            "timestamp" : "2018-04-05T17:39:53Z",
            "briefDesignDescription" : "NS vs. balanced crystalloids in ICU",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711584",
            "pageid" : 3555,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711584",
            "trainingLevel" : "student",
            "citation" : "Semler MW, <i>et al</i>. \"Balanced Crystalloids versus Saline in Critically Ill Adults\". <i>The New England Journal of Medicine</i>. 2018. 378(9):829-839.",
            "subspecialties" : "Critical Care;Nephrology",
            "expansion" : "Isotonic Solutions and Major Adverse Renal Events Trial",
            "statusUsableDate" : "2018-04-05",
            "briefResultsDescription" : "Balanced crystalloids slightly reduced composite rate of death, RRT, or CKD",
            "published" : "2018-03-01",
            "pageName" : "SMART-MED and SMART-SURG",
            "diseases" : "Critical Illness",
            "abbreviation" : "SMART",
            "title" : "Balanced Crystalloids versus Saline in Critically Ill Adults",
            "pmid" : "29485925"
        },
        {
            "timestamp" : "2017-01-19T19:50:29Z",
            "briefDesignDescription" : "Dopamine vs. norepinephrine in shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907118",
            "pageid" : 113,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907118",
            "trainingLevel" : "Intern",
            "citation" : "De Backer D, <i>et al</i>. \"Comparison of dopamine and norepinephrine in the treatment of shock\". <i>The New England Journal of Medicine</i>. 2010. 362(9):779-89.",
            "subspecialties" : "Critical Care;Emergency Medicine",
            "expansion" : "Sepsis Occurrence in Acutely Ill Patients II",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Norepinephrine reduces mortality",
            "published" : "2010-03-04",
            "pageName" : "SOAP II",
            "diseases" : "Sepsis;Shock",
            "abbreviation" : "SOAP II",
            "title" : "Comparison of dopamine and norepinephrine in the treatment of shock",
            "pmid" : "20200382"
        },
        {
            "timestamp" : "2017-12-03T22:39:15Z",
            "briefDesignDescription" : "Ticagrelor vs. aspirin in acute stroke or TIA",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603060",
            "pageid" : 2809,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603060",
            "trainingLevel" : "Resident",
            "citation" : "Johnston SC, <i>et al</i>. \"Ticagrelor versus aspirin in acute stroke or transient ischemic attack\". <i>New Engl J Med</i>. 2016. 365(1):35-43.",
            "subspecialties" : "Neurology",
            "expansion" : "Ticagrelor versus aspirin in stroke/TIA",
            "statusUsableDate" : "2016-10-01",
            "briefResultsDescription" : "Ticagrelor not superior to aspirin in acute stroke or TIA",
            "published" : "2016-07-07",
            "pageName" : "SOCRATES",
            "diseases" : "Stroke",
            "abbreviation" : "SOCRATES",
            "title" : "Ticagrelor versus aspirin in acute stroke or transient ischemic attack",
            "pmid" : "27160892"
        },
        {
            "timestamp" : "2017-12-03T22:39:16Z",
            "briefDesignDescription" : "Enalapril in moderate-severe HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199108013250501",
            "pageid" : 394,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199108013250501",
            "trainingLevel" : "Resident",
            "citation" : "Yusuf S, <i>et al</i>. \"Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure\". <i>The New England Journal of Medicine</i>. 1991. 325(5):293-302.",
            "subspecialties" : "Cardiology",
            "expansion" : "Studies of Left Ventricular Dysfunction",
            "statusUsableDate" : "2012-04-01",
            "briefResultsDescription" : "Enalapril reduces mortality and HF hospitalizations in HFrEF",
            "published" : "1991-08-01",
            "pageName" : "SOLVD",
            "diseases" : "Heart Failure",
            "abbreviation" : "SOLVD",
            "title" : "Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure",
            "pmid" : "2057034"
        },
        {
            "timestamp" : "2018-08-30T18:21:05Z",
            "briefDesignDescription" : "Occult cancer screening in unprovoked VTE",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506623",
            "pageid" : 2498,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506623",
            "trainingLevel" : "Intern",
            "citation" : "Carrier M, <i>et al</i>. \"Screening for Occult Cancer in Unprovoked Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2015. 373(8):697-704.",
            "subspecialties" : "Oncology;Hematology",
            "expansion" : "",
            "statusUsableDate" : "2018-08-30",
            "briefResultsDescription" : "No benefit over age-appropriate screening",
            "published" : "2015-08-20",
            "pageName" : "SOME",
            "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
            "abbreviation" : "SOME",
            "title" : "Screening for Occult Cancer in Unprovoked Venous Thromboembolism",
            "pmid" : "26095467"
        },
        {
            "timestamp" : "2017-12-03T22:39:17Z",
            "briefDesignDescription" : "Infliximab ± azathioprine induction in Crohn disease",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0904492",
            "pageid" : 1863,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0904492",
            "trainingLevel" : "Intern",
            "citation" : "Colombel JF, <i>et al</i>. \"Infliximab, azathioprine, or combination therapy for Crohn's disease\". <i>The New England Journal of Medicine</i>. 2010. 362(15):1383-1395.",
            "subspecialties" : "Gastroenterology",
            "expansion" : "Study of Biologic and Immunomodulator Naive Patients in Crohn's Disease",
            "statusUsableDate" : "2014-07-01",
            "briefResultsDescription" : "Combination therapy better than infliximab or azathioprine for Crohn disease induction therapy",
            "published" : "2010-04-15",
            "pageName" : "SONIC",
            "diseases" : "Inflammatory Bowel Disease;Crohn Disease",
            "abbreviation" : "SONIC",
            "title" : "Infliximab, azathioprine, or combination therapy for Crohn's disease",
            "pmid" : "20393175"
        },
        {
            "timestamp" : "2017-12-03T22:39:18Z",
            "briefDesignDescription" : "Aspirin and warfarin in AF",
            "fulltexturl" : "http://circ.ahajournals.org/content/84/2/527.long",
            "pageid" : 2340,
            "pdfurl" : "http://circ.ahajournals.org/content/84/2/527.full.pdf",
            "trainingLevel" : "Resident",
            "citation" : "SPAF Investigators. \"Stroke Prevention in Atrial Fibrillation Study. Final results\". <i>Circulation</i>. 1991. 84(2):527-39.",
            "subspecialties" : "Cardiology;Neurology",
            "expansion" : "Stroke Prevention in Atrial Fibrillation",
            "statusUsableDate" : "2016-08-01",
            "briefResultsDescription" : "Aspirin and warfarin reduce stroke incidence in AF",
            "published" : "1991-08-01",
            "pageName" : "SPAF",
            "diseases" : "Atrial Fibrillation;Stroke",
            "abbreviation" : "SPAF",
            "title" : "Stroke Prevention in Atrial Fibrillation Study. Final results",
            "pmid" : "1860198"
        },
        {
            "timestamp" : "2017-12-03T22:39:20Z",
            "briefDesignDescription" : "Atorvastatin after stroke",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061894",
            "pageid" : 461,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061894",
            "trainingLevel" : "intern",
            "citation" : "Amarenco P, <i>et al</i>. \"High-dose atorvastatin after stroke or transient ischemic attack\". <i>The New England Journal of Medicine</i>. 2006. 355(6):549-559.",
            "subspecialties" : "Neurology",
            "expansion" : "Stroke Prevention by Aggressive Reduction in Cholesterol Levels",
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "Atorvastatin ↓stroke risk in general but slightly ↑hemorrhagic strokes",
            "published" : "2006-08-10",
            "pageName" : "SPARCL",
            "diseases" : "Stroke;Hyperlipidemia;Transient Ischemic Attack",
            "abbreviation" : "SPARCL",
            "title" : "High-dose atorvastatin after stroke or transient ischemic attack",
            "pmid" : "16899775"
        },
        {
            "timestamp" : "2018-01-11T18:23:36Z",
            "briefDesignDescription" : "BP targets in high-risk patients",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1511939",
            "pageid" : 2487,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1511939",
            "trainingLevel" : "Student",
            "citation" : "The SPRINT Research Group. \"A randomized trial of intensive versus standard blood-pressure control\". <i>The New England Journal of Medicine</i>. 2015. 373(22):2103-2116.",
            "subspecialties" : "Cardiology;Preventive Medicine",
            "expansion" : "Systolic Blood Pressure Intervention Trial",
            "statusUsableDate" : "2015-11-01",
            "briefResultsDescription" : "SBP <120 improves CV outcomes with increased risks",
            "published" : "2015-11-09",
            "pageName" : "SPRINT",
            "diseases" : "Hypertension",
            "abbreviation" : "SPRINT",
            "title" : "A randomized trial of intensive versus standard blood-pressure control",
            "pmid" : "26551272"
        },
        {
            "timestamp" : "2017-12-03T22:39:22Z",
            "briefDesignDescription" : "Clopidogrel+ASA for lacunar strokes",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1204133",
            "pageid" : 2678,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1204133",
            "trainingLevel" : "Intern",
            "citation" : "SPS3 Study Group writers. \"Effects of clopidogrel added to aspirin in patients with recent lacunar stroke\". <i>New England Journal of Medicine</i>. 2012. 367(9):817-825.",
            "subspecialties" : "Neurology",
            "expansion" : "Secondary Prevention of Small Subcortical Strokes clopidogrel+ASA",
            "statusUsableDate" : "2016-06-01",
            "briefResultsDescription" : "Clopidogrel+ASA increased all cause mortality compared to ASA alone",
            "published" : "2012-08-30",
            "pageName" : "SPS3 Clopidogrel-ASA",
            "diseases" : "Stroke;Transient Ischemic Attack",
            "abbreviation" : "SPS3-Clopidogrel+ASA",
            "title" : "Effects of clopidogrel added to aspirin in patients with recent lacunar stroke",
            "pmid" : "22931315"
        },
        {
            "timestamp" : "2017-12-03T22:39:24Z",
            "briefDesignDescription" : "SBP <130 vs. SBP 130-150 after lacunar strokes",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60852-1/abstract",
            "pageid" : 2671,
            "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(13)60852-1.pdf",
            "trainingLevel" : "Intern",
            "citation" : "SPS3 Study Group. \"Blood-pressure targets in patients with recent lacunar stroke\". <i>The Lancet</i>. 2013. 382(9891):507-515.",
            "subspecialties" : "Neurology",
            "expansion" : "Secondary Prevention of Small Subcortical Strokes-Blood Pressure",
            "statusUsableDate" : "2016-01-01",
            "briefResultsDescription" : "No significant difference in all stroke types between two groups",
            "published" : "2013-05-29",
            "pageName" : "SPS3-BP",
            "diseases" : "Stroke",
            "abbreviation" : "SPS3-BP",
            "title" : "Blood-pressure targets in patients with recent lacunar stroke",
            "pmid" : "23726159"
        },
        {
            "timestamp" : "2018-06-29T18:11:38Z",
            "briefDesignDescription" : "Renal denervation in resistant hypertension",
            "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30951-6/fulltext",
            "pageid" : 3642,
            "pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(18)30951-6.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Kandazi DE, <i>et al</i>. \"Effect of renal denervation on blood pressure in the presence of antihypertensive drugs\". <i>The Lancet</i>. 2018. 391:2346-55.",
            "subspecialties" : "Cardiology",
            "expansion" : "Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy",
            "statusUsableDate" : "2018-06-12",
            "briefResultsDescription" : "Renal denervation+meds is superior to medical therapy alone in resistant hypertension",
            "published" : "2018-06-09",
            "pageName" : "SPYRAL HTN-ON MED",
            "diseases" : "Hypertension",
            "abbreviation" : "SPYRAL HTN-ON MED",
            "title" : "Effect of renal denervation on blood pressure in the presence of antihypertensive drugs",
            "pmid" : "29803589"
        },
        {
            "timestamp" : "2017-12-03T22:39:25Z",
            "briefDesignDescription" : "Gastric bypass vs. medical therapy for T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200225",
            "pageid" : 2266,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200225",
            "trainingLevel" : "Resident",
            "citation" : "Schauer PR, <i>et al</i>. \"Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes\". <i>The New England Journal of Medicine</i>. 2012. 366(17):1567-76.",
            "subspecialties" : "Endocrinology;Surgery",
            "expansion" : "Surgical Treatment and Medications Potentially Eradicate Diabetes Efficiently",
            "statusUsableDate" : "2015-01-01",
            "briefResultsDescription" : "Bypass plus medical therapy is superior to medical therapy alone",
            "published" : "2012-04-26",
            "pageName" : "STAMPEDE",
            "diseases" : "Diabetes Mellitus;Obesity",
            "abbreviation" : "STAMPEDE",
            "title" : "Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes",
            "pmid" : "22449319"
        },
        {
            "timestamp" : "2017-12-03T22:39:26Z",
            "briefDesignDescription" : "Tamoxifen vs. raloxifene in breast cancer prevention",
            "fulltexturl" : "http://jama.jamanetwork.com/article.aspx?articleid",
            "pageid" : 963,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5028/JOC60074.pdf",
            "trainingLevel" : "Fellow",
            "citation" : "Vogel VG, <i>et al</i>. \"Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes\". <i>Journal of the American Medical Association</i>. 2006. 295(23):2727-2741.",
            "subspecialties" : "Oncology",
            "expansion" : "Study of Tamoxifen and Raloxifene (NSABP P-2)",
            "statusUsableDate" : "2012-08-01",
            "briefResultsDescription" : "Similar reduction in breast cancer risk but fewer adverse effects with raloxifene",
            "published" : "2006-06-21",
            "pageName" : "STAR",
            "diseases" : "Breast Cancer",
            "abbreviation" : "STAR",
            "title" : "Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes",
            "pmid" : "16754727"
        },
        {
            "timestamp" : "2017-12-03T22:39:27Z",
            "briefDesignDescription" : "Tiered approach for depression",
            "fulltexturl" : "",
            "pageid" : 1564,
            "pdfurl" : "http://ajp.psychiatryonline.org/data/Journals/AJP/3782/06aj1905.PDF",
            "trainingLevel" : "Resident",
            "citation" : "Rush AJ <i>et al</i>. \"Acute and longer-term outcomes in depressed outpatient requiring one or several treatment steps: A STAR*D report\". <i>The American Journal of Psychiatry</i>. 2006. 163(11):1905-1917.",
            "subspecialties" : "Psychiatry",
            "expansion" : "Sequenced Treatment Alternatives to Relieve Depression",
            "statusUsableDate" : "2013-09-01",
            "briefResultsDescription" : "Most patients achieved remission in first two steps",
            "published" : "2006-11-01",
            "pageName" : "STAR-D",
            "diseases" : "Depression",
            "abbreviation" : "STAR-D",
            "title" : "Acute and longer-term outcomes in depressed outpatient requiring one or several treatment steps: A STAR*D report",
            "pmid" : "17074942"
        },
        {
            "timestamp" : "2017-12-03T22:39:28Z",
            "briefDesignDescription" : "CABG in ischemic HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1100356",
            "pageid" : 471,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1100356",
            "trainingLevel" : "Resident",
            "citation" : "Velazquez EJ, <i>et al</i>. \"Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction\". <i>The New England Journal of Medicine</i>. 2011. 354(17):1607-1616.",
            "subspecialties" : "Cardiology",
            "expansion" : "Surgical Treatment for Ischemic Heart Failure",
            "statusUsableDate" : "2012-12-01",
            "briefResultsDescription" : "No mortality benefit with CABG vs. OMT though improved CV outcomes",
            "published" : "2011-04-28",
            "pageName" : "STICH",
            "diseases" : "Heart Failure;Coronary Artery Disease",
            "abbreviation" : "STICH",
            "title" : "Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction",
            "pmid" : "21463150"
        },
        {
            "timestamp" : "2017-12-03T22:39:35Z",
            "briefDesignDescription" : "BR vs. R-CHOP for indolent lymphomas",
            "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(12)61763-2",
            "pageid" : 1664,
            "pdfurl" : "http://bit.ly/1owpykX",
            "trainingLevel" : "fellow",
            "citation" : "Rummel MJ, <i>et al</i>. \"Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial\". <i>The Lancet</i>. 2013. 381(9873):1203-10.",
            "subspecialties" : "Oncology;Hematology",
            "expansion" : "Study Group Indolent Lymphomas",
            "statusUsableDate" : "2014-06-01",
            "briefResultsDescription" : "BR superior to R-CHOP in PFS, similar in OS, less toxic",
            "published" : "2013-04-03",
            "pageName" : "StiL",
            "diseases" : "Lymphoma",
            "abbreviation" : "StiL",
            "title" : "Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial",
            "pmid" : "23433739"
        },
        {
            "timestamp" : "2017-12-03T22:39:30Z",
            "briefDesignDescription" : "Prednisolone vs. pentoxifylline in alcoholic hepatitis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1412278",
            "pageid" : 2365,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1412278",
            "trainingLevel" : "Intern",
            "citation" : "Thursz MR, <i>et al</i>. \"Prednisolone or pentoxifylline for alcoholic hepatitis\". <i>The New England Journal of Medicine</i>. 2015. 372(17):1619-1628.",
            "subspecialties" : "Gastroenterology",
            "expansion" : "Steroids or Pentoxifylline for Alcoholic Hepatitis",
            "statusUsableDate" : "2016-03-01",
            "briefResultsDescription" : "No difference between groups",
            "published" : "2015-04-23",
            "pageName" : "STOPAH",
            "diseases" : "Alcoholic Hepatitis",
            "abbreviation" : "STOPAH",
            "title" : "Prednisolone or pentoxifylline for alcoholic hepatitis",
            "pmid" : "25901427"
        },
        {
            "timestamp" : "2017-12-03T22:39:36Z",
            "briefDesignDescription" : "Palliative statin discontinuation",
            "fulltexturl" : "http://bit.ly/1LOZfB6",
            "pageid" : 2432,
            "pdfurl" : "",
            "trainingLevel" : "Resident",
            "citation" : "Kutner JS, <i>et al</i>. \"Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial\". <i>JAMA Internal Medicine</i>. 2015. 175(5):691-700.",
            "subspecialties" : "Palliative Care;Cardiology",
            "expansion" : "",
            "statusUsableDate" : "2015-09-01",
            "briefResultsDescription" : "Discontinuing statin doesn't change 60 day all-cause mortality",
            "published" : "2015-05-01",
            "pageName" : "Stopping Statins at the End of Life",
            "diseases" : "Hyperlipidemia",
            "abbreviation" : "",
            "title" : "Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial",
            "pmid" : "25798575"
        },
        {
            "timestamp" : "2017-12-03T22:39:31Z",
            "briefDesignDescription" : "TAVI for AS in intermediate-risk surgical candidates",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700456",
            "pageid" : 2895,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700456",
            "trainingLevel" : "Resident",
            "citation" : "Reardon MJ, <i>et al</i>. \"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients\". <i>The New England Journal of Medicine</i>. 2017. epub 2017-03-17:1-11.",
            "subspecialties" : "Cardiology",
            "expansion" : "Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement",
            "statusUsableDate" : "2017-04-01",
            "briefResultsDescription" : "TAVI noninferior to surgical AVR in intermediate-risk surgical candidates",
            "published" : "2017-03-17",
            "pageName" : "SURTAVI",
            "diseases" : "Aortic Stenosis",
            "abbreviation" : "SURTAVI",
            "title" : "Surgical or transcatheter aortic-valve replacement in intermediate-risk patients",
            "pmid" : "28304219"
        },
        {
            "timestamp" : "2017-12-03T22:39:32Z",
            "briefDesignDescription" : "Cytoreductive nephrectomy in metastatic RCC",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa003013",
            "pageid" : 1845,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa003013",
            "trainingLevel" : "Fellow",
            "citation" : "Flanigan RC, <i>et al</i>. \"Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer\". <i>The New England Journal of Medicine</i>. 2001. 345(23):1655-9.",
            "subspecialties" : "Oncology;Surgery;Urology",
            "expansion" : "",
            "statusUsableDate" : "2014-06-01",
            "briefResultsDescription" : "Cytoreductive nephrectomy improves survival in mRCC",
            "published" : "2001-12-06",
            "pageName" : "SWOG 8949",
            "diseases" : "Renal Cell Carcinoma",
            "abbreviation" : "SWOG 8949",
            "title" : "Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer",
            "pmid" : "11759643"
        },
        {
            "timestamp" : "2013-03-05T21:40:49Z",
            "briefDesignDescription" : "Symptom-triggered therapy in alcohol withdrawal",
            "fulltexturl" : "http://archinte.ama-assn.org/cgi/content/full/162/10/1117",
            "pageid" : 116,
            "pdfurl" : "http://archinte.ama-assn.org/cgi/reprint/162/10/1117.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Daeppen JB, <i>et al</i>. \"Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial\". <i>Archives of Internal Medicine</i>. 2002. 162(10):1117-21.",
            "subspecialties" : "Psychiatry",
            "expansion" : "",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Symptom-triggered therapy reduces length of hospitalization without increasing adverse event risk",
            "published" : "2002-05-27",
            "pageName" : "Symptom-Triggered Benzodiazepines in Alcohol Withdrawal",
            "diseases" : "Alcohol Withdrawal",
            "abbreviation" : "",
            "title" : "Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal: a randomized treatment trial",
            "pmid" : "12020181"
        },
        {
            "timestamp" : "2017-12-03T22:39:33Z",
            "briefDesignDescription" : "PCI vs. CABG in severe CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804626",
            "pageid" : 525,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804626",
            "trainingLevel" : "Resident",
            "citation" : "Serruys PW, <i>et al</i>. \"Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease\". <i>The New England Journal of Medicine</i>. 2009. 360(10):961-972.",
            "subspecialties" : "Cardiology;Surgery",
            "expansion" : "Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery",
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "CABG reduces major CV events with 3VD or LM disease",
            "published" : "2009-03-05",
            "pageName" : "SYNTAX",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "SYNTAX",
            "title" : "Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease",
            "pmid" : "19228612"
        },
        {
            "timestamp" : "2017-12-03T22:39:37Z",
            "briefDesignDescription" : "Early vs. Delayed PCI for UA-NSTEMI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200106213442501",
            "pageid" : 2656,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200106213442501",
            "trainingLevel" : "Resident",
            "citation" : "Cannon CP, <i>et al</i>. \"Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban\". <i>New England Journal of Medicine</i>. 2001. 344(25):1879-1887.",
            "subspecialties" : "Cardiology",
            "expansion" : "Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban",
            "statusUsableDate" : "2016-05-01",
            "briefResultsDescription" : "Early PCI improves outcomes in high-risk patients",
            "published" : "2001-06-21",
            "pageName" : "TACTICS-TIMI 18",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "TACTICS-TIMI 18",
            "title" : "Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban",
            "pmid" : "11419424"
        },
        {
            "timestamp" : "2017-12-03T22:39:38Z",
            "briefDesignDescription" : "Tiotropium vs. others in asthma",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1008770",
            "pageid" : 2267,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1008770",
            "trainingLevel" : "Fellow",
            "citation" : "Peters SP, <i>et al</i>. \"Tiotropium bromide step-up therapy for adults with uncontrolled asthma\". <i>The New England Journal of Medicine</i>. 2010. 363(18):1715-1726.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Tiotropium Bromide as an Alternative to Increased Inhaled Glucocorticoid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid",
            "statusUsableDate" : "2015-01-01",
            "briefResultsDescription" : "Adding tiotropium improves peak expiratory flow better than doubling the ICS dose",
            "published" : "2010-10-28",
            "pageName" : "TALC",
            "diseases" : "Asthma",
            "abbreviation" : "TALC",
            "title" : "Tiotropium bromide step-up therapy for adults with uncontrolled asthma",
            "pmid" : "20979471"
        },
        {
            "timestamp" : "2018-05-31T17:40:44Z",
            "briefDesignDescription" : "Early vs. delayed invasive intervention in NSTEMI and UA",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807986",
            "pageid" : 2867,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807986",
            "trainingLevel" : "Resident",
            "citation" : "Mehta SR, <i>et al</i>. \"Early versus Delayed Invasive Intervention in Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2009. 360:2165-2175.",
            "subspecialties" : "Cardiology",
            "expansion" : "The Timing of Intervention in Acute Coronary Syndromes",
            "statusUsableDate" : "2018-05-31",
            "briefResultsDescription" : "Early intervention does not differ greatly from delayed intervention in low- to moderate-risk patients",
            "published" : "2009-05-21",
            "pageName" : "TIMACS",
            "diseases" : "Acute Coronary Syndrome;Coronary Artery Disease;Myocardial Infarction",
            "abbreviation" : "TIMACS",
            "title" : "Early versus Delayed Invasive Intervention in Acute Coronary Syndromes",
            "pmid" : "19458363"
        },
        {
            "timestamp" : "2017-12-14T19:37:07Z",
            "briefDesignDescription" : "Atorvastatin in stable CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa050461",
            "pageid" : 1762,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa050461",
            "trainingLevel" : "Student",
            "citation" : "LaRosa JC, <i>et al</i>. \"Intensive lipid lowering with atorvastatin in patients with stable coronary disease\". <i>The New England Journal of Medicine</i>. 2005. 352(14):1425-1435.",
            "subspecialties" : "Cardiology",
            "expansion" : "Treating to New Targets",
            "statusUsableDate" : "2013-12-01",
            "briefResultsDescription" : "Atorvastatin 80 mg better than 10 mg for major CV events in stable CAD",
            "published" : "2005-04-07",
            "pageName" : "TNT",
            "diseases" : "Coronary Artery Disease;Hyperlipidemia",
            "abbreviation" : "TNT",
            "title" : "Intensive lipid lowering with atorvastatin in patients with stable coronary disease",
            "pmid" : "15755765"
        },
        {
            "timestamp" : "2017-12-14T19:36:29Z",
            "briefDesignDescription" : "Na reduction and weight loss for HTN control in elderly",
            "fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/vol/279/pg/839",
            "pageid" : 2990,
            "pdfurl" : "",
            "trainingLevel" : "Student",
            "citation" : "Whelton PK, <i>et al</i>. \"Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group\". <i>JAMA</i>. 1998. 279(11):839-846.",
            "subspecialties" : "Cardiology",
            "expansion" : "Trial of Nonpharmacologic Interventions in the Elderly",
            "statusUsableDate" : "2017-12-14",
            "briefResultsDescription" : "Na reduction and weight loss are effective means for hypertension control in the elderly",
            "published" : "1998-03-18",
            "pageName" : "TONE",
            "diseases" : "Hypertension",
            "abbreviation" : "TONE",
            "title" : "Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group",
            "pmid" : "9515998"
        },
        {
            "timestamp" : "2017-12-03T22:39:41Z",
            "briefDesignDescription" : "Spironolactone for HFpEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313731",
            "pageid" : 1797,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313731",
            "trainingLevel" : "Resident",
            "citation" : "Pitt B, <i>et al</i>. \"Spironolactone for heart failure with preserved ejection fraction\". <i>The New England Journal of Medicine</i>. 2014. 370(15):1383-1392.",
            "subspecialties" : "Cardiology",
            "expansion" : "Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist",
            "statusUsableDate" : "2014-05-01",
            "briefResultsDescription" : "Spironolactone doesn't reduce CV mortality, aborted cardiac arrest or HF hospitalizations in HFpEF",
            "published" : "2014-04-20",
            "pageName" : "TOPCAT",
            "diseases" : "Heart Failure",
            "abbreviation" : "TOPCAT",
            "title" : "Spironolactone for heart failure with preserved ejection fraction",
            "pmid" : "24716680"
        },
        {
            "timestamp" : "2015-05-29T16:40:40Z",
            "briefDesignDescription" : "Salmeterol/fluticasone in COPD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa063070",
            "pageid" : 124,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa063070",
            "trainingLevel" : "Student",
            "citation" : "Calverley PM, <i>et al</i>. \"Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease\". <i>The New England Journal of Medicine</i>. 2007. 356(8):775-789.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Towards a Revolution in COPD Health",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Trend towards mortality benefit",
            "published" : "2007-02-22",
            "pageName" : "TORCH",
            "diseases" : "Chronic Obstructive Pulmonary Disease",
            "abbreviation" : "TORCH",
            "title" : "Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease",
            "pmid" : "17314337"
        },
        {
            "timestamp" : "2017-12-03T22:39:47Z",
            "briefDesignDescription" : "Transfusion thresholds in UGIB",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211801",
            "pageid" : 1191,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211801",
            "trainingLevel" : "Intern",
            "citation" : "Villanueva C <i>et al</i>. \"Transfusion strategies for acute upper gastrointestinal bleeding\". <i>The New England Journal of Medicine</i>. 2013. 368(1):11-21.",
            "subspecialties" : "Gastroenterology",
            "expansion" : "",
            "statusUsableDate" : "2013-02-01",
            "briefResultsDescription" : "Restrictive transfusions lower mortality in UGIB",
            "published" : "2013-01-03",
            "pageName" : "Transfusion Strategies for Acute Upper Gastrointestinal Bleeding",
            "diseases" : "Gastrointestinal Hemorrhage;Hemorrhage",
            "abbreviation" : "",
            "title" : "Transfusion strategies for acute upper gastrointestinal bleeding",
            "pmid" : "23281973"
        },
        {
            "timestamp" : "2018-10-18T17:42:04Z",
            "briefDesignDescription" : "Rivaroxaban in high-risk APLS",
            "fulltexturl" : "https://doi.org/10.1182/blood-2018-04-848333",
            "pageid" : 3700,
            "pdfurl" : null,
            "trainingLevel" : "Fellow",
            "citation" : "Pengo V, <i>et al</i>. \"Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome\". <i>Blood</i>. 2018. 132(13):1365-1371.",
            "subspecialties" : "Hematology;Rheumatology",
            "expansion" : "Trial on Rivaroxaban in AntiPhospholipid Syndrome",
            "statusUsableDate" : "2018-10-19",
            "briefResultsDescription" : "Rivaroxaban inferior to warfarin in high-risk APLS",
            "published" : "2018-09-27",
            "pageName" : "TRAPS",
            "diseases" : "Antiphospholipid Syndrome",
            "abbreviation" : "TRAPS",
            "title" : "Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome",
            "pmid" : "30002145"
        },
        {
            "timestamp" : "2015-03-09T17:49:43Z",
            "briefDesignDescription" : "Darbepoetin in CKD and T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0907845",
            "pageid" : 5,
            "pdfurl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0907845",
            "trainingLevel" : "Resident",
            "citation" : "Pfeffer MA, <i>et al</i>. \"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease\". <i>The New England Journal of Medicine</i>. 2009. 361(21):2019-32.",
            "subspecialties" : "Nephrology;Hematology;Endocrinology",
            "expansion" : "Trial to Reduce Cardiovascular Events With Aranesp Therapy",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "No mortality benefit when targeting higher hemoglobin with ESAs in patients with CKD and T2DM",
            "published" : "2009-11-19",
            "pageName" : "TREAT",
            "diseases" : "Chronic Kidney Disease;Anemia;Diabetes Mellitus",
            "abbreviation" : "TREAT",
            "title" : "A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease",
            "pmid" : "19880844"
        },
        {
            "timestamp" : "2017-01-19T20:08:09Z",
            "briefDesignDescription" : "Transfusion thresholds in ICU",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199902113400601",
            "pageid" : 104,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199902113400601",
            "trainingLevel" : "Intern",
            "citation" : "Hebert PC, <i>et al</i>. \"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care\". <i>The New England Journal of Medicine</i>. 1999. 340(6):409-417.",
            "subspecialties" : "Critical Care;Hematology",
            "expansion" : "Transfusion Requirements in Critical Care",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Restrictive hemoglobin goals improved mortality",
            "published" : "1999-02-11",
            "pageName" : "TRICC",
            "diseases" : "Anemia",
            "abbreviation" : "TRICC",
            "title" : "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care",
            "pmid" : "9971864"
        },
        {
            "timestamp" : "2018-04-26T17:40:38Z",
            "briefDesignDescription" : "Transfusion thresholds for cardiac surgery",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711818",
            "pageid" : 3536,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711818",
            "trainingLevel" : "Resident",
            "citation" : "Mazer CD, <i>et al</i>. \"Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery\". <i>The New England Journal of Medicine</i>. 2017. 377(22):2133-44.",
            "subspecialties" : "Surgery;Hematology",
            "expansion" : "Transfusion Requirements in Cardiac Surgery",
            "statusUsableDate" : "2018-04-26",
            "briefResultsDescription" : "Restrictive noninferior to liberal RBC transfusions",
            "published" : "2017-11-30",
            "pageName" : "TRICS III",
            "diseases" : "Anemia",
            "abbreviation" : "TRICS III",
            "title" : "Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery",
            "pmid" : "29130845"
        },
        {
            "timestamp" : "2017-12-03T22:39:42Z",
            "briefDesignDescription" : "Transfusion thresholds in sepsis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1406617",
            "pageid" : 2268,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1406617",
            "trainingLevel" : "Intern",
            "citation" : "Holst L, <i>et al</i>. \"Transfusion thresholds in Septic Shock\". <i>The New England Journal of Medicine</i>. 2014. 371(15):1381-1391.",
            "subspecialties" : "Critical Care",
            "expansion" : "Transfusion Requirements in Septic Shock",
            "statusUsableDate" : "2014-12-01",
            "briefResultsDescription" : "Similar mortality; Fewer transfusions with restrictive",
            "published" : "2014-10-09",
            "pageName" : "TRISS",
            "diseases" : "Sepsis;Shock;Anemia",
            "abbreviation" : "TRISS",
            "title" : "Transfusion thresholds in Septic Shock",
            "pmid" : "25270275"
        },
        {
            "timestamp" : "2017-12-03T22:39:43Z",
            "briefDesignDescription" : "Prasugrel vs. clopidogrel in ACS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706482",
            "pageid" : 1398,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706482",
            "trainingLevel" : "Resident",
            "citation" : "Wiviott ST, <i>et al</i>. \"Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2007. 357(20):2001-2015.",
            "subspecialties" : "Cardiology",
            "expansion" : "Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel–Thrombolysis in Myocardial Infarction 38",
            "statusUsableDate" : "2013-04-01",
            "briefResultsDescription" : "Prasugrel decreases CV mortality/morbidity, increases bleeding",
            "published" : "2007-11-15",
            "pageName" : "TRITON-TIMI 38",
            "diseases" : "Acute Coronary Syndrome",
            "abbreviation" : "TRITON-TIMI 38",
            "title" : "Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes",
            "pmid" : "17982182"
        },
        {
            "timestamp" : "2017-12-03T22:39:45Z",
            "briefDesignDescription" : "Eculizumab in PNH",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061648",
            "pageid" : 2810,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061648",
            "trainingLevel" : "Intern",
            "citation" : "Hillmen P, <i>et al</i>. \"The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria\". <i>The New England Journal of Medicine</i>. 2006. 355(12):1233-1243.",
            "subspecialties" : "Hematology",
            "expansion" : "Transfusion Reduction Efficacy and Safety Clinical Investigation, a Randomized, Multicenter, Double-Blind, Placebo-Controlled, Using Eculizumab in Paroxysmal Nocturnal Hemoglobinuria",
            "statusUsableDate" : "2017-08-01",
            "briefResultsDescription" : "Eculizumab decreases transfusion requirements in PNH",
            "published" : "2006-09-21",
            "pageName" : "TRIUMPH",
            "diseases" : "Paroxysmal Nocturnal Hemoglobinuria",
            "abbreviation" : "TRIUMPH",
            "title" : "The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria",
            "pmid" : "16990386"
        },
        {
            "timestamp" : "2017-12-03T22:39:46Z",
            "briefDesignDescription" : "33 vs. 36°C body temperature after cardiac arrest",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310519",
            "pageid" : 1783,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310519",
            "trainingLevel" : "Resident",
            "citation" : "Nielsen N, <i>et al</i>. \"Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest\". <i>The New England Journal of Medicine</i>. 2013. 369(23):2197-2206.",
            "subspecialties" : "Cardiology;Neurology;Critical Care",
            "expansion" : "Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest",
            "statusUsableDate" : "2014-03-01",
            "briefResultsDescription" : "33°C cooling provides no survival benefit over 36°C",
            "published" : "2014-03-19",
            "pageName" : "TTM",
            "diseases" : "Cardiac Arrest",
            "abbreviation" : "TTM",
            "title" : "Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest",
            "pmid" : "24237006"
        },
        {
            "timestamp" : "2017-12-03T22:39:48Z",
            "briefDesignDescription" : "Twice-daily RT in limited SCLC",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199901283400403",
            "pageid" : 1773,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199901283400403",
            "trainingLevel" : "Resident",
            "citation" : "Turrisi AT, <i>et al</i>. \"Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide\". <i>The New England Journal of Medicine</i>. 1999. 340(4):265-271.",
            "subspecialties" : "Oncology;Pulmonology;Radiation Oncology",
            "expansion" : "",
            "statusUsableDate" : "2013-12-01",
            "briefResultsDescription" : "Twice-daily RT with better response, PFS, survival than once-daily RT for limited SCLC",
            "published" : "1999-01-28",
            "pageName" : "Twice-daily RT for SCLC",
            "diseases" : "Lung Cancer",
            "abbreviation" : "",
            "title" : "Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide",
            "pmid" : "9920950"
        },
        {
            "timestamp" : "2018-09-11T23:25:53Z",
            "briefDesignDescription" : "Intensive glycemic therapy in T2DM",
            "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140673698070196",
            "pageid" : 253,
            "pdfurl" : "",
            "trainingLevel" : "Intern",
            "citation" : "Turner R, <i>et al</i>. \"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes\". <i>The Lancet</i>. 1998. 352(9131):837-53.",
            "subspecialties" : "Endocrinology",
            "expansion" : "United Kingdom Prospective Diabetes Study",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Reduction in microvascular complications",
            "published" : "1998-09-12",
            "pageName" : "UKPDS 33",
            "diseases" : "Diabetes Mellitus",
            "abbreviation" : "UKPDS",
            "title" : "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes",
            "pmid" : "9742976"
        },
        {
            "timestamp" : "2017-12-03T22:39:50Z",
            "briefDesignDescription" : "Metformin in T2DM",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2898%2907037-8/fulltext",
            "pageid" : 1747,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673698070378.pdf",
            "trainingLevel" : "Intern",
            "citation" : "UKPDS Study Group. \"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.\". <i>The Lancet</i>. 1998. 352(9131):854-865.",
            "subspecialties" : "Endocrinology",
            "expansion" : "UK Prospective Diabetes Study 34",
            "statusUsableDate" : "2014-01-01",
            "briefResultsDescription" : "Metformin better than diet alone in T2DM",
            "published" : "1998-11-07",
            "pageName" : "UKPDS 34",
            "diseases" : "Diabetes Mellitus",
            "abbreviation" : "UKPDS 34",
            "title" : "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.",
            "pmid" : "9742977"
        },
        {
            "timestamp" : "2012-10-29T23:28:48Z",
            "briefDesignDescription" : "Tiotropium in COPD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0805800",
            "pageid" : 123,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0805800",
            "trainingLevel" : "Resident",
            "citation" : "Tashkin DP, <i>et al</i>. \"A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease\". <i>The New England Journal of Medicine</i>. 2008. 395(15):1543-1554.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Understanding Potential Long-Term Impacts on Function with Tiotropium",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Decreased exacerbations and mortality",
            "published" : "2008-10-09",
            "pageName" : "UPLIFT",
            "diseases" : "Chronic Obstructive Pulmonary Disease",
            "abbreviation" : "UPLIFT",
            "title" : "A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease",
            "pmid" : "18836213"
        },
        {
            "timestamp" : "2017-12-03T22:39:51Z",
            "briefDesignDescription" : "ISDN/hydralazine in HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198606123142404",
            "pageid" : 155,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198606123142404",
            "trainingLevel" : "student",
            "citation" : "Cohn JN, <i>et al</i>. \"Effect of vasodilator therapy on mortality in chronic congestive heart failure\". <i>The New England Journal of Medicine</i>. 1986. 314(24):1547-52.",
            "subspecialties" : "Cardiology",
            "expansion" : "Vasodilator Heart Failure Trial",
            "statusUsableDate" : "2012-12-01",
            "briefResultsDescription" : "Trend towards mortality benefit in ISDN/hydralazine",
            "published" : "1986-06-12",
            "pageName" : "V-HeFT",
            "diseases" : "Heart Failure",
            "abbreviation" : "V-HeFT",
            "title" : "Effect of vasodilator therapy on mortality in chronic congestive heart failure",
            "pmid" : "3520315"
        },
        {
            "timestamp" : "2018-04-13T13:08:04Z",
            "briefDesignDescription" : "Enalapril vs. ISDN/hydralazine in HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199108013250502",
            "pageid" : 2943,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199108013250502",
            "trainingLevel" : "Student",
            "citation" : "Cohn JN, <i>et al</i>. \"A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure\". <i>The New England Journal of Medicine</i>. 1991. 325(5):303-310.",
            "subspecialties" : "Cardiology",
            "expansion" : "Vasodilator Heart Failure Trial II",
            "statusUsableDate" : "2017-11-01",
            "briefResultsDescription" : "Enalapril improves survival in HFrEF",
            "published" : "1991-08-01",
            "pageName" : "V-HeFT II",
            "diseases" : "Heart Failure",
            "abbreviation" : "V-HeFT II",
            "title" : "A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure",
            "pmid" : "2057035"
        },
        {
            "timestamp" : "2014-09-24T22:23:54Z",
            "briefDesignDescription" : "Aspirin in unstable angina",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198308183090703",
            "pageid" : 261,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198308183090703",
            "trainingLevel" : "Resident",
            "citation" : "Lewis HD, <i>et al</i>. \"Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study\". <i>The New England Journal of Medicine</i>. 1983. 309(7):396-403.",
            "subspecialties" : "Cardiology",
            "expansion" : null,
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Aspirin decreases mortality",
            "published" : "1983-08-18",
            "pageName" : "VA Cooperative Study",
            "diseases" : "Acute Coronary Syndrome",
            "abbreviation" : null,
            "title" : "Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina -- Results of a Veterans Administration Cooperative Study",
            "pmid" : "6135989"
        },
        {
            "timestamp" : "2018-01-11T18:14:18Z",
            "briefDesignDescription" : "ACE+ARB in DM nephropathy",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1303154",
            "pageid" : 1798,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1303154",
            "trainingLevel" : "Resident",
            "citation" : "Fried LF, <i>et al</i>. \"Combined angiotensin inhibition for the treatment of diabetic nephropathy\". <i>The New England Journal of Medicine</i>. 2013. 369(20):1892-1903.",
            "subspecialties" : "Nephrology;Endocrinology",
            "expansion" : "Veterans Affairs Nephropathy in Diabetes",
            "statusUsableDate" : "2014-05-01",
            "briefResultsDescription" : "ACE+ARB no more effective than monotherapy, increases complications",
            "published" : "2013-11-14",
            "pageName" : "VA-NEPHRON D",
            "diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
            "abbreviation" : "VA NEPHRON-D",
            "title" : "Combined angiotensin inhibition for the treatment of diabetic nephropathy",
            "pmid" : "24206457"
        },
        {
            "timestamp" : "2018-08-12T16:18:00Z",
            "briefDesignDescription" : "Intensive glycemic therapy in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0808431",
            "pageid" : 254,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0808431",
            "trainingLevel" : "Resident",
            "citation" : "Duckworth W, <i>et al</i>. \"Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2009. 360(2):129-39.",
            "subspecialties" : "Endocrinology",
            "expansion" : "Veterans Affairs Diabetes Trial",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "No effect on macrovascular or severe microvascular outcomes",
            "published" : "2009-01-08",
            "pageName" : "VADT",
            "diseases" : "Diabetes Mellitus",
            "abbreviation" : "VADT",
            "title" : "Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes",
            "pmid" : "19092145"
        },
        {
            "timestamp" : "2014-08-24T17:55:57Z",
            "briefDesignDescription" : "Valsartan in HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010713",
            "pageid" : 20,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010713",
            "trainingLevel" : "Resident",
            "citation" : "Cohn JN, <i>et al</i>. \"A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure\". <i>New England Journal of Medicine</i>. 2001. 345(23):1667-75.",
            "subspecialties" : "Cardiology",
            "expansion" : "Valsartan Heart Failure Trial",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "No mortality benefit of valsartan in NYHA II-IV HF",
            "published" : "2001-12-06",
            "pageName" : "Val-HeFT",
            "diseases" : "Heart Failure",
            "abbreviation" : "Val-HeFT",
            "title" : "A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure",
            "pmid" : "11759645"
        },
        {
            "timestamp" : "2017-12-03T22:39:54Z",
            "briefDesignDescription" : "Sofosbuvir+ribavirin for HCV genotypes 2 or 3",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1316145",
            "pageid" : 2261,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1316145",
            "trainingLevel" : "Student",
            "citation" : "Zeuzem S, <i>et al</i>. \"Sofosbuvir and ribavirin in HCV genotypes 2 and 3\". <i>The New England Journal of Medicine</i>. 2014. 370(21):1993-2001.",
            "subspecialties" : "Infectious Disease;Gastroenterology",
            "expansion" : "",
            "statusUsableDate" : "2014-12-01",
            "briefResultsDescription" : "Sofosbuvir+ribavirin effective without IFN",
            "published" : "2014-05-22",
            "pageName" : "VALENCE",
            "diseases" : "Hepatitis C",
            "abbreviation" : "VALENCE",
            "title" : "Sofosbuvir and ribavirin in HCV genotypes 2 and 3",
            "pmid" : "24795201"
        },
        {
            "timestamp" : "2015-07-05T22:55:54Z",
            "briefDesignDescription" : "Valsartan vs. captopril in MI with LV dysfunction",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa032292",
            "pageid" : 462,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa032292",
            "trainingLevel" : "Resident",
            "citation" : "Pfeffer, MA <i>et al</i>. \"Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both\". <i>The New England Journal of Medicine</i>. 2003. 349(20):1893-1903.",
            "subspecialties" : "Cardiology",
            "expansion" : "Valsartan in Acute Myocardial Infarction Trial",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Valsartan as effective as captopril",
            "published" : "2003-11-13",
            "pageName" : "VALIANT",
            "diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : "VALIANT",
            "title" : "Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both",
            "pmid" : "12921816"
        },
        {
            "timestamp" : "2014-07-28T20:00:24Z",
            "briefDesignDescription" : "Vancomycin vs. metronidazole in C. difficile",
            "fulltexturl" : "http://cid.oxfordjournals.org/content/45/3/302.long",
            "pageid" : 6,
            "pdfurl" : "http://cid.oxfordjournals.org/content/45/3/302.full.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Zar FA, <i>et al</i>. \"A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity\". <i>Clinical Infectious Diseases</i>. 2007. 45(3):302-7.",
            "subspecialties" : "Infectious Disease;Gastroenterology",
            "expansion" : null,
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Vancomycin is superior to metronidazole in severe C. difficile-associated diarrhea",
            "published" : "2007-08-01",
            "pageName" : "Vancomycin vs. Metronidazole in C. difficile Diarrhea",
            "diseases" : "Clostridium difficile",
            "abbreviation" : null,
            "title" : "A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity",
            "pmid" : "17599306"
        },
        {
            "timestamp" : "2017-12-03T22:39:56Z",
            "briefDesignDescription" : "Ablation vs. antiarrhythmic drugs in VT",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1513614",
            "pageid" : 2783,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1513614",
            "trainingLevel" : "Resident",
            "citation" : "Sapp JL, <i>et al</i>. \"Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs\". <i>The New England Journal of Medicine</i>. 2016. 375(2):111-121.",
            "subspecialties" : "Cardiology",
            "expansion" : "Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs",
            "statusUsableDate" : "2016-06-01",
            "briefResultsDescription" : "VT ablation superior to escalation of antiarrhythmic drugs",
            "published" : "2016-05-05",
            "pageName" : "VANISH",
            "diseases" : "Ventricular Tachycardia",
            "abbreviation" : "VANISH",
            "title" : "Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs",
            "pmid" : "27149033"
        },
        {
            "timestamp" : "2017-12-03T22:39:57Z",
            "briefDesignDescription" : "Vasopressin in septic shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067373",
            "pageid" : 1910,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067373",
            "trainingLevel" : "Resident",
            "citation" : "Russel JA, <i>et al</i>. \"Vasopressin versus norepinephrine infusion in patients with septic shock\". <i>The New England Journal of Medicine</i>. 2008. 358(9):877-887.",
            "subspecialties" : "Critical Care",
            "expansion" : "Vasopressin and Septic Shock Trial",
            "statusUsableDate" : "2014-08-01",
            "briefResultsDescription" : "Vasopressin doesn't reduce mortality in shock",
            "published" : "2008-02-28",
            "pageName" : "VASST",
            "diseases" : "Sepsis;Shock",
            "abbreviation" : "VASST",
            "title" : "Vasopressin versus norepinephrine infusion in patients with septic shock",
            "pmid" : "18305265"
        },
        {
            "timestamp" : "2017-12-03T22:39:59Z",
            "briefDesignDescription" : "Aspirin after VTE treatment",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1114238",
            "pageid" : 1244,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1114238",
            "trainingLevel" : "resident",
            "citation" : "Becattini C, <i>et al</i>. \"Aspirin for preventing the recurrence of venous thromboembolism\". <i>The New England Journal of Medicine</i>. 2012. 366(21):1959-1967.",
            "subspecialties" : "Hematology",
            "expansion" : "Warfarin and Aspirin",
            "statusUsableDate" : "2013-03-01",
            "briefResultsDescription" : "Aspirin reduces recurrent VTE",
            "published" : "2012-05-24",
            "pageName" : "WARFASA",
            "diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
            "abbreviation" : "WARFASA",
            "title" : "Aspirin for preventing the recurrence of venous thromboembolism",
            "pmid" : "22621626"
        },
        {
            "timestamp" : "2017-12-03T22:40:01Z",
            "briefDesignDescription" : "Postmenopausal estrogen/progesterone",
            "fulltexturl" : null,
            "pageid" : 1507,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4840/JOC21036.pdf",
            "trainingLevel" : "Student",
            "citation" : "Rossouw JE, <i>et al</i>. \"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial\". <i>The Journal of the American Medical Association</i>. 2002. 288(3):321-333.",
            "subspecialties" : "Gynecology;Endocrinology",
            "expansion" : "Women's Health Initiative Estrogen and Progestin Trial",
            "statusUsableDate" : "2013-07-01",
            "briefResultsDescription" : "Postmenopausal estrogen/progesterone HRT increases rates of MI and breast cancer",
            "published" : "2002-07-17",
            "pageName" : "WHI",
            "diseases" : "Coronary Artery Disease;Menopause",
            "abbreviation" : "WHI E+P",
            "title" : "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial",
            "pmid" : "12117397"
        },
        {
            "timestamp" : "2017-12-03T22:40:03Z",
            "briefDesignDescription" : "ICS withdrawal in COPD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407154",
            "pageid" : 2318,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407154",
            "trainingLevel" : "Resident",
            "citation" : "Magnussen H, <i>et al</i>. \"Withdrawal of inhaled glucocorticoids and exacerbations of COPD\". <i>The New England Journal of Medicine</i>. 2014. 371(14):1285-1295.",
            "subspecialties" : "Pulmonology",
            "expansion" : "Withdrawal of Inhaled Steroids during Optimized Bronchodilator Management",
            "statusUsableDate" : "2015-05-01",
            "briefResultsDescription" : "ICS withdrawal may reduce FEV1, no change in COPD flares",
            "published" : "2014-10-02",
            "pageName" : "WISDOM",
            "diseases" : "Chronic Obstructive Pulmonary Disease",
            "abbreviation" : "WISDOM",
            "title" : "Withdrawal of inhaled glucocorticoids and exacerbations of COPD",
            "pmid" : "25196117"
        },
        {
            "timestamp" : "2017-12-03T22:40:05Z",
            "briefDesignDescription" : "Clopidogrel ± ASA after PCI if on OAC",
            "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0140673612621771",
            "pageid" : 1792,
            "pdfurl" : "",
            "trainingLevel" : "Resident",
            "citation" : "Dewilde WJM, <i>et al</i>. \"Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial\". <i>The Lancet</i>. 2013. 381(9872):1107-1115.",
            "subspecialties" : "Cardiology;Hematology",
            "expansion" : "What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing",
            "statusUsableDate" : "2015-06-01",
            "briefResultsDescription" : "ASA increases bleeding when added to clopidogrel if chronic OAC",
            "published" : "2013-03-30",
            "pageName" : "WOEST",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "WOEST",
            "title" : "Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial",
            "pmid" : "23415013"
        },
        {
            "timestamp" : "2014-12-12T19:39:51Z",
            "briefDesignDescription" : "Pravastatin in CAD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199511163332001",
            "pageid" : 172,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199511163332001",
            "trainingLevel" : "Resident",
            "citation" : "Shepherd J, <i>et al</i>. \"Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia\". <i>The New England Journal of Medicine</i>. 1995. 333(20):1301-1308.",
            "subspecialties" : "Cardiology",
            "expansion" : "West of Scotland Coronary Prevention Study",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Pravastatin reduces MIs and CV mortality",
            "published" : "1995-11-16",
            "pageName" : "WOSCOPS",
            "diseases" : "Hyperlipidemia;Coronary Artery Disease",
            "abbreviation" : "WOSCOPS",
            "title" : "Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia",
            "pmid" : "7566020"
         },
         },
         {
         {
             "timestamp" : "2014-07-28T20:00:24Z",
             "timestamp" : "2017-12-03T22:40:06Z",
             "briefDesignDescription" : "Vancomycin vs. metronidazole in C. difficile",
             "briefDesignDescription" : "RSBI for predicting weaning",
            "fulltexturl" : "http://cid.oxfordjournals.org/content/45/3/302.long",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199105233242101",
            "pageid" : 6,
             "pageid" : 75,
            "pdfurl" : "http://cid.oxfordjournals.org/content/45/3/302.full.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199105233242101",
            "trainingLevel" : "Intern",
            "citation" : "Zar FA, <i>et al</i>. \"A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity\". <i>Clinical Infectious Diseases</i>. 2007. 45(3):302-7.",
            "subspecialties" : "Infectious Disease;Gastroenterology",
            "expansion" : null,
            "briefResultsDescription" : "Vancomycin is superior to metronidazole in severe C. difficile-associated diarrhea",
            "published" : "2007-08-01",
            "pageName" : "Vancomycin vs. Metronidazole in C. difficile Diarrhea",
            "diseases" : "Clostridium difficile",
            "abbreviation" : null,
            "title" : "A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity",
            "pmid" : "17599306"
        },
        {
            "timestamp" : "2014-12-12T19:39:51Z",
            "briefDesignDescription" : "Pravastatin in CAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199511163332001",
             "pageid" : 172,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199511163332001",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Shepherd J, <i>et al</i>. \"Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia\". <i>The New England Journal of Medicine</i>. 1995. 333(20):1301-1308.",
             "citation" : "Yang KL, Tobin MJ. \"A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation\". <i>The New England Journal of Medicine</i>. 1991. 324(21):1445-1450.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Pulmonology;Critical Care",
             "expansion" : "West of Scotland Coronary Prevention Study",
             "expansion" : "",
             "briefResultsDescription" : "Pravastatin reduces MIs and CV mortality",
            "statusUsableDate" : "2013-01-01",
             "published" : "1995-11-16",
             "briefResultsDescription" : "RSBI predicts success and failure of weaning from mechanical ventilation",
             "pageName" : "WOSCOPS",
             "published" : "1991-05-23",
             "diseases" : "Hyperlipidemia;Coronary Artery Disease",
             "pageName" : "Yang-Tobin Study",
             "abbreviation" : "WOSCOPS",
             "diseases" : "Critical Illness",
             "title" : "Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia",
             "abbreviation" : "",
             "pmid" : "7566020"
             "title" : "A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation",
             "pmid" : "2023603"
         }
         }
       ]
       ]
   }
   }
}
}
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