Feed:Recent Updates: Difference between revisions

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==November 2022==
; [[AID-ICU]]: New summary #466: Haloperidol for ICU delirium
==October 2022==
==October 2022==
; [[DELIVER]]: New summary #466: Dapagliflozin in HFmrEF or HFpEF
; [[DELIVER]]: New summary #465: Dapagliflozin in HFmrEF or HFpEF


; [[NordICC]]: New summary #465: Invitations for screening colonoscopy
; [[NordICC]]: New summary #464: Invitations for screening colonoscopy


==September 2022==
==September 2022==
; [[ADVOR]]: New summary #464: Acetazolamide in ADHF
; [[ADVOR]]: New summary #463: Acetazolamide in ADHF


==August 2022==
==August 2022==
; [[TICORA]]: New summary #463: Intensive vs. standard treatment in early RA
; [[TICORA]]: New summary #462: Intensive vs. standard treatment in early RA


==July 2022==
==July 2022==
; [[NAVIGATE ESUS]]: New summary #462: Rivaroxaban vs. ASA for ESUS (stroke)
; [[NAVIGATE ESUS]]: New summary #461: Rivaroxaban vs. ASA for ESUS (stroke)


; [[NACSTOP]]: New summary #461: 12 vs. 20 hours of NAC in APAP overdose
; [[NACSTOP]]: New summary #460: 12 vs. 20 hours of NAC in APAP overdose


==June 2022==
==June 2022==
; [[CRB-401]]: New summary #460: Ide-cel CART in myeloma
; [[CRB-401]]: New summary #459: Ide-cel CART in myeloma


==May 2022==
==May 2022==
Line 23: Line 26:


==April 2022==
==April 2022==
; [[MERINO]]: New summary #459: Piperacillin-tazobactam for ESBL bacteremia
; [[MERINO]]: New summary #458: Piperacillin-tazobactam for ESBL bacteremia


==March 2022==
==March 2022==
; [[WARSS]]: New summary #458: Aspirin vs. warfarin in ischemic stroke
; [[WARSS]]: New summary #457: Aspirin vs. warfarin in ischemic stroke


; [[RITUXVAS]]: New summary #457: Rituximab in ANCA-Renal Vasculitis
; [[RITUXVAS]]: New summary #456: Rituximab in ANCA-Renal Vasculitis


==February 2022==
==February 2022==
Line 43: Line 46:


==November 2021==
==November 2021==
; [[STEP]]: New summary #456: Intensive BP control hypertension
; [[STEP]]: New summary #455: Intensive BP control hypertension


; [[ASPEN]]: New summary #455: Zanubrutinib vs. ibrutinib in WM
; [[ASPEN]]: New summary #454: Zanubrutinib vs. ibrutinib in WM


==October 2021==
==October 2021==
; [[EARLY-AF]]: New summary #454: Cryoablation vs. antiarrhythmics in AF
; [[EARLY-AF]]: New summary #453: Cryoablation vs. antiarrhythmics in AF


; [[MASTER DAPT]]: New summary #453: Abbreviated DAPT in high-risk bleeding
; [[MASTER DAPT]]: New summary #452: Abbreviated DAPT in high-risk bleeding


; [[EARLY AF]]: New summary #452: Cryoablation vs. antiarrhythmics in AF
; [[EARLY AF]]: New summary #451: Cryoablation vs. antiarrhythmics in AF


==September 2021==
==September 2021==
; [[ANTLER]]: New summary #451: Maintenance vs. discontinuation of antidepressants
; [[ANTLER]]: New summary #450: Maintenance vs. discontinuation of antidepressants


; [[DELIRIA-J]]: New summary #450: Ramelteon vs. placebo to prevent delirium
; [[DELIRIA-J]]: New summary #449: Ramelteon vs. placebo to prevent delirium


; [[EMPEROR-Preserved]]: New summary #449: Empagliflozin in HFmrEF and HFpEF
; [[EMPEROR-Preserved]]: New summary #448: Empagliflozin in HFmrEF and HFpEF


==August 2021==
==August 2021==
; [[HORIZON-PFT]]: New summary #448: Zoledronate vs. placebo in osteoporosis
; [[HORIZON-PFT]]: New summary #447: Zoledronate vs. placebo in osteoporosis


; [[65 Trial]]: New summary #447: MAP 60-65 vs. usual care in vasodilatory hypotension in ICU
; [[65 Trial]]: New summary #446: MAP 60-65 vs. usual care in vasodilatory hypotension in ICU


==July 2021==
==July 2021==
; [[TTM2]]: New summary #446: 33 vs. 36°C body temperature after cardiac arrest
; [[TTM2]]: New summary #445: 33 vs. 36°C body temperature after cardiac arrest


; [[REALITY]]: New summary #445: Transfusion thresholds in MI
; [[REALITY]]: New summary #444: Transfusion thresholds in MI


; [[PREVAIL]]: New summary #444: LAA closure vs. warfarin in AF
; [[PREVAIL]]: New summary #443: LAA closure vs. warfarin in AF


==June 2021==
==June 2021==
; [[MRFIT]]: New summary #443: CHD risk modification for CHD mortality prevention
; [[MRFIT]]: New summary #442: CHD risk modification for CHD mortality prevention


==May 2021==
==May 2021==
; [[PERC]]: New summary #442: PE rule-out criteria
; [[PERC]]: New summary #441: PE rule-out criteria


; [[Novel START]]: New summary #441: ICS+LABA PRN in mild asthma
; [[Novel START]]: New summary #440: ICS+LABA PRN in mild asthma


==April 2021==
==April 2021==
; [[PAUSE]]: New summary #440: Perioperative DOAC holding protocols in AF
; [[PAUSE]]: New summary #439: Perioperative DOAC holding protocols in AF


; [[STEP 1]]: New summary #439: Semaglutide in obesity without diabetes
; [[STEP 1]]: New summary #438: Semaglutide in obesity without diabetes


==March 2021==
==March 2021==
; [[How Long]]: New summary #438: Duration of empiric antibiotics in ↑risk neutropenic fever
; [[How Long]]: New summary #437: Duration of empiric antibiotics in ↑risk neutropenic fever


; [[APROCCHSS]]: New summary #437: Steroids in septic shock
; [[APROCCHSS]]: New summary #436: Steroids in septic shock


==February 2021==
==February 2021==
; [[LoDoCo2]]: New summary #436: Colchicine in stable CAD
; [[LoDoCo2]]: New summary #435: Colchicine in stable CAD


; [[PATHWAY-2]]: New summary #435: Spironolactone for resistant HTN
; [[PATHWAY-2]]: New summary #434: Spironolactone for resistant HTN


==January 2021==
==January 2021==
; [[EAST-AFNET 4]]: New summary #434: Early rhythm vs. rate control in AF
; [[EAST-AFNET 4]]: New summary #433: Early rhythm vs. rate control in AF


; [[ISCHEMIA]]: New summary #433: PCI/CABG vs. medical therapy in stable CAD
; [[ISCHEMIA]]: New summary #432: PCI/CABG vs. medical therapy in stable CAD


; [[PRAETORIAN]]: New summary #432: Transvenous vs. subq ICD to prevent sudden cardiac death
; [[PRAETORIAN]]: New summary #431: Transvenous vs. subq ICD to prevent sudden cardiac death


==December 2020==
==December 2020==
; [[SUSTAIN]]: New summary #431: Crizanlizumab vs. placebo in SCD
; [[SUSTAIN]]: New summary #430: Crizanlizumab vs. placebo in SCD


; [[MIST2]]: New summary #430: tPA and/or DNase for pleural infection
; [[MIST2]]: New summary #429: tPA and/or DNase for pleural infection


; [[HOPE (Sickle Cell Disease)]]: New summary #429: Voxelotor in sickle cell disease
; [[HOPE (Sickle Cell Disease)]]: New summary #428: Voxelotor in sickle cell disease


==November 2020==
==November 2020==
; [[ALLHAT-LLT Elderly]]: New summary #428: Pravastatin vs usual care for ASCVD primary prevention
; [[ALLHAT-LLT Elderly]]: New summary #427: Pravastatin vs usual care for ASCVD primary prevention


==October 2020==
==October 2020==
; [[CARAVAGGIO]]: New summary #427: Apixaban vs. dalteparin in cancer VTE
; [[CARAVAGGIO]]: New summary #426: Apixaban vs. dalteparin in cancer VTE


; [[DAPA-CKD]]: New summary #426: Dapagliflozin in CKD±T2DM
; [[DAPA-CKD]]: New summary #425: Dapagliflozin in CKD±T2DM


==September 2020==
==September 2020==
; [[VITAMINS]]: New summary #425: Vitamin C, hydrocortisone, & thiamine in septic shock
; [[VITAMINS]]: New summary #424: Vitamin C, hydrocortisone, & thiamine in septic shock


==August 2020==
==August 2020==
; [[RECOVERY (Covid-19)]]: New summary #424: Dexamethasone vs. usual care in Covid-19
; [[RECOVERY (Covid-19)]]: New summary #423: Dexamethasone vs. usual care in Covid-19


; [[B-CONVINCED]]: New summary #423: Beta-blocker withdrawal in ADHF
; [[B-CONVINCED]]: New summary #422: Beta-blocker withdrawal in ADHF


==July 2020==
==July 2020==
; On paternity leave! Back in a couple of weeks.
; On paternity leave! Back in a couple of weeks.


; [[PARAGON-HF]]: New summary #422: ARNI in symptomatic HFpEF
; [[PARAGON-HF]]: New summary #421: ARNI in symptomatic HFpEF


==June 2020==
==June 2020==
; [[AMAZES]]: New summary #421: Azithromycin in chronic asthma
; [[AMAZES]]: New summary #420: Azithromycin in chronic asthma


; [[ACTT-1]]: New summary #420: Remdesivir vs. placebo in Covid-19
; [[ACTT-1]]: New summary #419: Remdesivir vs. placebo in Covid-19


==May 2020==
==May 2020==
; [[SPICE III]]: New summary #419: Dexmedetomidine in ICU sedation
; [[SPICE III]]: New summary #418: Dexmedetomidine in ICU sedation


==March & April 2020==
==March & April 2020==
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==February 2020==
==February 2020==
; [[Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia]]: New summary #418: Ibrutinib-rituximab vs. FCR in untreated CLL
; [[Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia]]: New summary #417: Ibrutinib-rituximab vs. FCR in untreated CLL


; [[HPS Statin]]: New summary #417: Simvastatin in high risk for CVD
; [[HPS Statin]]: New summary #416: Simvastatin in high risk for CVD


==January 2020==
==January 2020==
; [[STOP-IT]]: New summary #416: Duration of abx in intraabdominal infection
; [[STOP-IT]]: New summary #415: Duration of abx in intraabdominal infection


; [[DAWN]]: New summary #415: Thrombectomy 6-24 hours after stroke
; [[DAWN]]: New summary #414: Thrombectomy 6-24 hours after stroke


==December 2019==
==December 2019==
; On paternity leave!: Back in January 2020.
; On paternity leave!: Back in January 2020.


; [[DAPA-HF]]: New summary #414: Dapagliflozin in HFrEF
; [[DAPA-HF]]: New summary #413: Dapagliflozin in HFrEF


==November 2019==
==November 2019==
; [[COLCOT]]: New summary #413: Colchicine vs. placebo in ACS
; [[COLCOT]]: New summary #412: Colchicine vs. placebo in ACS


; [[CORAL]]: New summary #412: Stenting vs. medical therapy in RAS
; [[CORAL]]: New summary #411: Stenting vs. medical therapy in RAS


==October 2019==
==October 2019==
; [[PARTNER 3]]: New summary #411: TAVR for AS in low-risk surgical candidates
; [[PARTNER 3]]: New summary #410: TAVR for AS in low-risk surgical candidates


; [[AUGUSTUS]]: New summary #410: DOAC, VKA, antiplatelets after PCI with stent and AF
; [[AUGUSTUS]]: New summary #409: DOAC, VKA, antiplatelets after PCI with stent and AF


; [[ISAR-REACT 5]]: New summary #409: Ticagrelor vs. prasugrel in ACS
; [[ISAR-REACT 5]]: New summary #408: Ticagrelor vs. prasugrel in ACS


==September 2019==
==September 2019==
; [[HOPE-3]]: New summary #408: Statin, BP meds, both, or neither for CVD 1° prevention
; [[HOPE-3]]: New summary #407: Statin, BP meds, both, or neither for CVD 1° prevention


; [[EASE]]: New summary #407: Early surgery in endocarditis
; [[EASE]]: New summary #406: Early surgery in endocarditis


; [[S-HYDRACYST]]: New summary #406: Increasing water intake to prevent UTIs in women
; [[S-HYDRACYST]]: New summary #405: Increasing water intake to prevent UTIs in women


; [[3C]]: New summary #405: Antibiotic strategies in lower respiratory tract infections
; [[3C]]: New summary #404: Antibiotic strategies in lower respiratory tract infections


==August 2019==
==August 2019==
; [[RAMPART]]: New summary #404: Midazolam vs. lorazepam for status epilepticus
; [[RAMPART]]: New summary #403: Midazolam vs. lorazepam for status epilepticus


; [[AASK]]: New summary #403: BP management for CKD in African Americans
; [[AASK]]: New summary #402: BP management for CKD in African Americans


==July 2019==
==July 2019==
; [[CREDENCE]]: New summary #402: Canagliflozin in diabetic nephropathy
; [[CREDENCE]]: New summary #401: Canagliflozin in diabetic nephropathy


; [[ARREST]]: New summary #401: Rifampin in S. aureus bacteremia
; [[ARREST]]: New summary #400: Rifampin in S. aureus bacteremia


; [[DODS]]: New summary #400: D-dimer based anticoagulation discontinuation
; [[DODS]]: New summary #399: D-dimer based anticoagulation discontinuation


==June 2019==
==June 2019==
; [[WASID]]: New summary #399: Warfarin vs. aspirin for intracranial atherosclerosis
; [[WASID]]: New summary #398: Warfarin vs. aspirin for intracranial atherosclerosis


; [[SPACE]]: New summary #398: Opioids vs. non-opioids in chronic MSK pain
; [[SPACE]]: New summary #397: Opioids vs. non-opioids in chronic MSK pain


; [[TRED-HF]]: New summary #397: Withdrawal of medications in dilated cardiomyopathy
; [[TRED-HF]]: New summary #396: Withdrawal of medications in dilated cardiomyopathy


; [[TIPPS]]: New summary #396: Dalteparin in pregnant woman with thrombophilias
; [[TIPPS]]: New summary #395: Dalteparin in pregnant woman with thrombophilias


; [[ROSE]]: New summary #395: Cisatracurium NM blockade in ARDS
; [[ROSE]]: New summary #394: Cisatracurium NM blockade in ARDS


==May 2019==
==May 2019==
; [[IALT]]: New summary #394: Adjuvant cisplatin in resected NSCLC
; [[IALT]]: New summary #393: Adjuvant cisplatin in resected NSCLC


; [[ASPREE]]: New summary #393: Aspirin for ASCVD 1° prevention if age >70
; [[ASPREE]]: New summary #392: Aspirin for ASCVD 1° prevention if age >70


; [[DONATE-HCV]]: New summary #392: Donor HCV positive heart and lung transplant
; [[DONATE-HCV]]: New summary #391: Donor HCV positive heart and lung transplant


==April 2019==
==April 2019==
; [[REMATCH]]: New summary #391: Destination LVAD in end-stage heart failure
; [[REMATCH]]: New summary #390: Destination LVAD in end-stage heart failure


; [[OVIVA]]: New summary #390: PO vs. IV antibiotics for bone/joint infection
; [[OVIVA]]: New summary #389: PO vs. IV antibiotics for bone/joint infection


; [[POET]]: New summary #389: PO abx after 10d IV abx for left-sided endocarditis
; [[POET]]: New summary #388: PO abx after 10d IV abx for left-sided endocarditis


; [[CABANA]]: New summary #388: Catheter ablation vs. anti-arrhythmic therapy in AF
; [[CABANA]]: New summary #387: Catheter ablation vs. anti-arrhythmic therapy in AF


==March 2019==
==March 2019==
; [[CASSINI]]: New summary #387: Rivaroxaban for VTE prevention in cancer
; [[CASSINI]]: New summary #386: Rivaroxaban for VTE prevention in cancer


; [[CAPRICORN]]: New summary #386: Carvedilol post-MI with HFrEF
; [[CAPRICORN]]: New summary #385: Carvedilol post-MI with HFrEF


; [[IDEAL-ICU]]: New summary #385: Early vs. delayed RRT in septic shock
; [[IDEAL-ICU]]: New summary #384: Early vs. delayed RRT in septic shock


; [[FAIR-HF]]: New summary #384: Parenteral iron in HFrEF with iron deficiency
; [[FAIR-HF]]: New summary #383: Parenteral iron in HFrEF with iron deficiency


==February 2019==
==February 2019==
; [[BICAR-ICU]]: New summary #383: Bicarbonate in severe metabolic acidosis
; [[BICAR-ICU]]: New summary #382: Bicarbonate in severe metabolic acidosis


; [[ProMISe]]: New summary #382: Multicenter EGDT trial in severe sepsis
; [[ProMISe]]: New summary #381: Multicenter EGDT trial in severe sepsis


; [[ANNEXA-4]]: New summary #381: Andexanet alfa for factor Xa inhibitor reversal
; [[ANNEXA-4]]: New summary #380: Andexanet alfa for factor Xa inhibitor reversal


; [[ART]]: New summary #380: Bilateral vs. single IMA graft in multivessel CAD
; [[ART]]: New summary #379: Bilateral vs. single IMA graft in multivessel CAD


==January 2019==
==January 2019==
; [[PIONEER-HF]]: New summary #379: ARNI started in ADHF hospitalization
; [[PIONEER-HF]]: New summary #378: ARNI started in ADHF hospitalization


; [[AVERT]]: New summary #378: Apixaban for VTE prevention in cancer
; [[AVERT]]: New summary #377: Apixaban for VTE prevention in cancer


==December 2018==
==December 2018==
; [[REDUCE-IT]]: New summary #377: Icosapent ethyl in CAD
; [[REDUCE-IT]]: New summary #376: Icosapent ethyl in CAD


; [[SELECT-D]]: New summary #376: Rivaroxaban vs. LMWH in cancer VTE
; [[SELECT-D]]: New summary #375: Rivaroxaban vs. LMWH in cancer VTE


; [[AURORA]]: New summary #375: Rosuvastatin in ESRD
; [[AURORA]]: New summary #374: Rosuvastatin in ESRD


; [[COAPT]]: New summary #374: Mitra Clip for HF-related MR
; [[COAPT]]: New summary #373: Mitra Clip for HF-related MR


; [[AF-CHF]]: New summary #373: Rhythm control for AF in HFrEF
; [[AF-CHF]]: New summary #372: Rhythm control for AF in HFrEF


==November 2018==
==November 2018==
; [[MIND-USA]]: New summary #372: Antipsychotics in ICU delirium
; [[MIND-USA]]: New summary #371: Antipsychotics in ICU delirium


; [[CIRT]]: New summary #371: Low-dose MTX for secondary prevention of CAD
; [[CIRT]]: New summary #370: Low-dose MTX for secondary prevention of CAD


; [[DIVA]]: New summary #370: BMS vs. DES for saphenous vein graft PCI
; [[DIVA]]: New summary #369: BMS vs. DES for saphenous vein graft PCI


; [[APEX]]: New summary #369: Betrixaban for extended VTE prophylaxis
; [[APEX]]: New summary #368: Betrixaban for extended VTE prophylaxis


; [[SUP-ICU]]: New summary #368: Routine PPI use in the ICU
; [[SUP-ICU]]: New summary #367: Routine PPI use in the ICU


==October 2018==
==October 2018==
; [[VEST]]: New summary #367: Wearable cardioverter-defibrillator post-MI
; [[VEST]]: New summary #366: Wearable cardioverter-defibrillator post-MI


; [[Radiograph vs. MRI for low back pain]]: New summary #366: Radiograph vs. MRI for low back pain
; [[Radiograph vs. MRI for low back pain]]: New summary #365: Radiograph vs. MRI for low back pain


; [[LenDex in High-Risk Smoldering Myeloma]]: New summary #365: Lenalidomide/dexamethasone in smoldering MM
; [[LenDex in High-Risk Smoldering Myeloma]]: New summary #364: Lenalidomide/dexamethasone in smoldering MM


; [[TRAPS]]: New summary #364: Rivaroxaban in high-risk APLS
; [[TRAPS]]: New summary #363: Rivaroxaban in high-risk APLS


==September 2018==
==September 2018==
; [[MARINER]]: New summary #363: Rivaroxaban VTE ppx after medical admission
; [[MARINER]]: New summary #362: Rivaroxaban VTE ppx after medical admission


; [[EMBRACE]]: New summary #362: Extended EKG monitoring after cryptogenic stroke
; [[EMBRACE]]: New summary #361: Extended EKG monitoring after cryptogenic stroke


; [[ATTR-ACT]]: New summary #361: Tafamidis vs. placebo in amyloid cardiomyopathy
; [[ATTR-ACT]]: New summary #360: Tafamidis vs. placebo in amyloid cardiomyopathy


; [[ASCEND (Aspirin)]]: New summary #360: Aspirin for vascular disease prevention in DM
; [[ASCEND (Aspirin)]]: New summary #359: Aspirin for vascular disease prevention in DM


; [[ACOSOG Z0011]]: New summary #359: ALND in SLND-positive breast cancer
; [[ACOSOG Z0011]]: New summary #358: ALND in SLND-positive breast cancer


==August 2018==
==August 2018==
; [[SOME]]: New summary #358: Occult cancer screening in unprovoked VTE
; [[SOME]]: New summary #357: Occult cancer screening in unprovoked VTE


; [[Early TIPS]]: New summary #357: Early TIPS in high-risk cirrhotic variceal bleeding
; [[Early TIPS]]: New summary #356: Early TIPS in high-risk cirrhotic variceal bleeding


; [[Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock]]: New summary #356: Hydrocortisone, Vit C, and thiamine in sepsis
; [[Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock]]: New summary #355: Hydrocortisone, Vit C, and thiamine in sepsis


; [[POINT]]: New summary #355: Aspirin/clopidogrel vs. aspirin in stroke/TIA
; [[POINT]]: New summary #354: Aspirin/clopidogrel vs. aspirin in stroke/TIA


==July 2018==
==July 2018==
; [[APPAC]]: New summary #354: Antibiotics vs. surgery for acute appendicitis
; [[APPAC]]: New summary #353: Antibiotics vs. surgery for acute appendicitis


; [[RESCUEicp]]: New summary #353: Craniectomy vs. medical care for intracranial hypertension
; [[RESCUEicp]]: New summary #352: Craniectomy vs. medical care for intracranial hypertension


; [[ATTRACT]]: New summary #352: Pharmacomechanical therapy vs. anticoagulation in DVT
; [[ATTRACT]]: New summary #351: Pharmacomechanical therapy vs. anticoagulation in DVT


; Welcome new medical students, interns, residents, and fellows!: Buckle in for a year to remember. We hope Journal Club makes it a touch easier. You got this!
; Welcome new medical students, interns, residents, and fellows!: Buckle in for a year to remember. We hope Journal Club makes it a touch easier. You got this!


==June 2018==
==June 2018==
; [[MOMENTUM 3]]: New summary #351: Centrifugal-flow LVAD vs. axial-flow LVAD in advanced HF
; [[MOMENTUM 3]]: New summary #350: Centrifugal-flow LVAD vs. axial-flow LVAD in advanced HF


; [[SPYRAL HTN-ON MED]]: New summary #350: Renal denervation in resistant hypertension
; [[SPYRAL HTN-ON MED]]: New summary #349: Renal denervation in resistant hypertension


; [[RABBIT 2]]: New summary #349: Basal-bolus insulin in inpatients with DM
; [[RABBIT 2]]: New summary #348: Basal-bolus insulin in inpatients with DM


; [[PREDIMED]]: We incorporated our thoughts on the retraction and replacement of this high-impact NEJM trial on the Mediterranean diet for prevention of CVD.
; [[PREDIMED]]: We incorporated our thoughts on the retraction and replacement of this high-impact NEJM trial on the Mediterranean diet for prevention of CVD.


==May 2018==
==May 2018==
; [[TIMACS]]: New summary #348: Early vs. delayed PCI in NSTEMI and UA
; [[TIMACS]]: New summary #347: Early vs. delayed PCI in NSTEMI and UA


; [[DPP]]: New summary #347: Metformin and intensive lifestyle in prediabetes
; [[DPP]]: New summary #346: Metformin and intensive lifestyle in prediabetes


; [[DANAMI-3 PRIMULTI]]: New summary #346: Culprit lesion PCI vs. FFR in multivessel CAD
; [[DANAMI-3 PRIMULTI]]: New summary #345: Culprit lesion PCI vs. FFR in multivessel CAD


==April 2018==
==April 2018==
; [[OASIS-5]]: New summary #345: Fondaparinux vs. enoxaparin in NSTE-ACS
; [[OASIS-5]]: New summary #344: Fondaparinux vs. enoxaparin in NSTE-ACS


; [[TRICS III]]: New summary #344: Transfusion thresholds for cardiac surgery
; [[TRICS III]]: New summary #343: Transfusion thresholds for cardiac surgery


; [[SMART-MED and SMART-SURG]]: New summary #343: NS vs. balanced crystalloids in ICU
; [[SMART-MED and SMART-SURG]]: New summary #342: NS vs. balanced crystalloids in ICU


; [[SALT-ED]]: New summary #342: Balanced crystalloids vs. NS in non-critical ED patients
; [[SALT-ED]]: New summary #341: Balanced crystalloids vs. NS in non-critical ED patients


; [[Blood Pressure Reduction in Black Barbershops]]: New summary #341: PharmD-guided BP reduction for black men in barbershops
; [[Blood Pressure Reduction in Black Barbershops]]: New summary #340: PharmD-guided BP reduction for black men in barbershops


==March 2018==
==March 2018==
; [[INPULSIS Trials]]: New summary #340: Nintedanib in IPF
; [[INPULSIS Trials]]: New summary #339: Nintedanib in IPF


; [[EPCAT II]]: New summary #339: Aspirin vs. rivaroxaban for postoperative VTE prophylaxis
; [[EPCAT II]]: New summary #338: Aspirin vs. rivaroxaban for postoperative VTE prophylaxis


; [[HEMO]]: New summary #338: High dialysis dose and high-flux membrane in hemodialysis
; [[HEMO]]: New summary #337: High dialysis dose and high-flux membrane in hemodialysis


; [[Compare-Acute]]: New summary #337: Multivessel PCI vs. FFR-guided complete revascularization
; [[Compare-Acute]]: New summary #336: Multivessel PCI vs. FFR-guided complete revascularization


; [[CAP-START]]: New summary #336: Antibiotic strategies for PNA
; [[CAP-START]]: New summary #335: Antibiotic strategies for PNA


==February 2018==
==February 2018==
; [[Hokusai-VTE]]: New summary #335: Edoxaban vs. LMWH in cancer VTE
; [[Hokusai-VTE]]: New summary #334: Edoxaban vs. LMWH in cancer VTE


; [[EUROPA]]: New summary #334: Perindopril in patients with stable CAD
; [[EUROPA]]: New summary #333: Perindopril in patients with stable CAD


; [[CASTLE-AF]]: New summary #333: Catheter ablation vs. standard therapy in AF+HF
; [[CASTLE-AF]]: New summary #332: Catheter ablation vs. standard therapy in AF+HF


; [[ADRENAL]]: New summary #332: Hydrocortisone in septic shock
; [[ADRENAL]]: New summary #331: Hydrocortisone in septic shock


; [[Hokusai VTE Cancer Trial]]: New summary #331: Edoxaban vs. LMWH in cancer VTE
; [[Hokusai VTE Cancer Trial]]: New summary #330: Edoxaban vs. LMWH in cancer VTE


==January 2018==
==January 2018==
; [[RE-DUAL]]: New summary #330: Triple therapy vs. ASA+dabigatran in PCI if AF
; [[RE-DUAL]]: New summary #329: Triple therapy vs. ASA+dabigatran in PCI if AF


; [[PROTECT AF]]: New summary #329: LAA closure vs. warfarin in AF
; [[PROTECT AF]]: New summary #328: LAA closure vs. warfarin in AF


; [[ACCORD Lipid]]: New summary #328: Fibrate add-on to statins in T2DM
; [[ACCORD Lipid]]: New summary #327: Fibrate add-on to statins in T2DM


==December 2017==
==December 2017==
; [[TONE]]: New summary #327: Na reduction and weight loss for HTN control in elderly
; [[TONE]]: New summary #326: Na reduction and weight loss for HTN control in elderly


; [[ORBITA]]: New summary #326: PCI vs. medical therapy in stable angina
; [[ORBITA]]: New summary #325: PCI vs. medical therapy in stable angina


; [[FOCUS]]: New summary #325: Transfusion thresholds after hip surgery
; [[FOCUS]]: New summary #324: Transfusion thresholds after hip surgery


==November 2017==
==November 2017==
; [[CAMERA]]: New summary #324: Methotrexate strategies in RA
; [[CAMERA]]: New summary #323: Methotrexate strategies in RA


; [[ALMS]]: New summary #323: MMF vs. CTX in lupus nephritis
; [[ALMS]]: New summary #322: MMF vs. CTX in lupus nephritis


; [[CULPRIT-SHOCK]]: New summary #322: Culprit-only vs. multivessel PCI in cardiogenic shock
; [[CULPRIT-SHOCK]]: New summary #321: Culprit-only vs. multivessel PCI in cardiogenic shock


; [[V-HeFT II]]: New summary #321: Enalapril vs. ISDN/hydralazine in HFrEF
; [[V-HeFT II]]: New summary #320: Enalapril vs. ISDN/hydralazine in HFrEF


==October 2017==
==October 2017==
; [[DETO2X-AMI]]: New summary #320: Oxygen for suspected MI
; [[DETO2X-AMI]]: New summary #319: Oxygen for suspected MI


; [[RELAX]]: New summary #319: Sildenafil vs. placebo in HFpEF
; [[RELAX]]: New summary #318: Sildenafil vs. placebo in HFpEF


; [[PROLONG]]: New summary #318: D-Dimer testing after VTE
; [[PROLONG]]: New summary #317: D-Dimer testing after VTE


; [[CANTOS]]: New summary #317: Canakinumab in patients with previous MI
; [[CANTOS]]: New summary #316: Canakinumab in patients with previous MI


==September 2017==
==September 2017==
; [[POP-UP]]: New summary #316: PPIs for stress ulcer prophylaxis
; [[POP-UP]]: New summary #315: PPIs for stress ulcer prophylaxis


; [[Albumin for SBP]]: New summary #315: Albumin for SBP in cirrhosis
; [[Albumin for SBP]]: New summary #314: Albumin for SBP in cirrhosis


; [[COMPASS]]: New summary #314: Rivaroxaban, ASA, or both in stable CAD
; [[COMPASS]]: New summary #313: Rivaroxaban, ASA, or both in stable CAD


; [[HEAT]]: New summary #313: Acetaminophen in febrile ICU patients
; [[HEAT]]: New summary #312: Acetaminophen in febrile ICU patients


; [[AVOID]]: New summary #312: Supplemental oxygen in STEMI
; [[AVOID]]: New summary #311: Supplemental oxygen in STEMI


==August 2017==
==August 2017==
; [[CANVAS]]: New summary #311: Canagliflozin for CV outcomes in T2DM
; [[CANVAS]]: New summary #310: Canagliflozin for CV outcomes in T2DM


; [[TRIUMPH]]: New summary #310: Eculizumab in PNH
; [[TRIUMPH]]: New summary #309: Eculizumab in PNH


; [[AKIKI]]: New summary #309: Early vs. late RRT in severe AKI in ICU
; [[AKIKI]]: New summary #308: Early vs. late RRT in severe AKI in ICU


; [[ATHOS-3]]: New summary #308: Angiotensin II vs. placebo in vasodilatory shock
; [[ATHOS-3]]: New summary #307: Angiotensin II vs. placebo in vasodilatory shock


==July 2017==
==July 2017==
; Welcome new medical students, interns, residents, and fellows! : This is going to be a tough but great year. We hope Journal Club makes it a touch easier for you.
; Welcome new medical students, interns, residents, and fellows! : This is going to be a tough but great year. We hope Journal Club makes it a touch easier for you.


; [[IRONOUT-HF]]: New summary #307: Oral iron vs. placebo in HFrEF and iron deficiency
; [[IRONOUT-HF]]: New summary #306: Oral iron vs. placebo in HFrEF and iron deficiency


; [[EINSTEIN CHOICE]]: New summary #306: Rivaroxaban after VTE treatment
; [[EINSTEIN CHOICE]]: New summary #305: Rivaroxaban after VTE treatment


==June 2017==
==June 2017==
; [[AIDA]]: New summary #305: Scaffold vs. stent in PCI
; [[AIDA]]: New summary #304: Scaffold vs. stent in PCI


; [[BLOCK-HF]]: New summary #304: RV pacing vs. BiV pacing in HF with AV block
; [[BLOCK-HF]]: New summary #303: RV pacing vs. BiV pacing in HF with AV block


; [[CHAMPION PHOENIX]]: New summary #303: Cangrelor during urgent or elective PCI
; [[CHAMPION PHOENIX]]: New summary #302: Cangrelor during urgent or elective PCI


==May 2017==
==May 2017==
; [[IFR-SWEDEHEART]]: New summary #302: iFR vs. FFR for PCI
; [[IFR-SWEDEHEART]]: New summary #301: iFR vs. FFR for PCI


; [[MODIFY I and II]]: New summary #301: Bezlotoxumab for C. diff recurrence prevention
; [[MODIFY I and II]]: New summary #300: Bezlotoxumab for C. diff recurrence prevention


; [[BEST]]: New summary #300: PCI vs. CABG for multivessel disease
; [[BEST]]: New summary #299: PCI vs. CABG for multivessel disease


==April 2017==
==April 2017==
; [[Cranberry for prevention of pyuria and bacteriuria]]: New summary #299: Cranberry in for prevention of pyuria and bacteriuria
; [[Cranberry for prevention of pyuria and bacteriuria]]: New summary #298: Cranberry in for prevention of pyuria and bacteriuria


; [[SURTAVI]]: New summary #298: TAVI for AS in intermediate-risk surgical candidates
; [[SURTAVI]]: New summary #297: TAVI for AS in intermediate-risk surgical candidates


==March 2017==
==March 2017==
; [[ANNEXA]]: New summary #297: Andexanet for reversing Xa inhibitors
; [[ANNEXA]]: New summary #296: Andexanet for reversing Xa inhibitors


; [[FOURIER]]: New summary #296: Evolocumab for CVD events if atherosclerotic disease
; [[FOURIER]]: New summary #295: Evolocumab for CVD events if atherosclerotic disease


; [[PRECISION]]: New summary #295: Celecoxib, naproxen, or ibuprofen for CV safety in arthritis
; [[PRECISION]]: New summary #294: Celecoxib, naproxen, or ibuprofen for CV safety in arthritis


==February 2017==
==February 2017==
; [[ENGAGE AF-TIMI 48]]: New summary #294: Edoxaban vs. warfarin in AF
; [[ENGAGE AF-TIMI 48]]: New summary #293: Edoxaban vs. warfarin in AF


; [[CvLPRIT]]: New summary #293: Culprit lesion-only vs. complete revascularization
; [[CvLPRIT]]: New summary #292: Culprit lesion-only vs. complete revascularization


==January 2017==
==January 2017==
; [[FLAME (COPD)]]: New summary #292: LABA+LAMA vs. LABA+ICS in COPD
; [[FLAME (COPD)]]: New summary #291: LABA+LAMA vs. LABA+ICS in COPD


; Updated Surviving Sepsis guidelines: [[Daily ICU Sedation Holidays]], [[ATN]], [[ARDSNet]], [[ACURASYS]], [[PROSEVA]], [[OSCILLATE]], [[Leuven Surgical Trial]], [[NICE-SUGAR]], [[PRORATA]], [[TRICC]], [[ALBIOS]], [[SAFE]], [[CRISTAL]], [[VASST]], [[SOAP II]], [[SEPSISPAM]], [[CORTICUS]], [[Annane Trial]], [[ProMISe]], [[ARISE]], [[ProCESS]], [[Rivers Trial]]
; Updated Surviving Sepsis guidelines: [[Daily ICU Sedation Holidays]], [[ATN]], [[ARDSNet]], [[ACURASYS]], [[PROSEVA]], [[OSCILLATE]], [[Leuven Surgical Trial]], [[NICE-SUGAR]], [[PRORATA]], [[TRICC]], [[ALBIOS]], [[SAFE]], [[CRISTAL]], [[VASST]], [[SOAP II]], [[SEPSISPAM]], [[CORTICUS]], [[Annane Trial]], [[ProMISe]], [[ARISE]], [[ProCESS]], [[Rivers Trial]]


; [[EUCLID (Ticagrelor)]]: New summary #291: Ticagrelor vs. clopidogrel in symptomatic PAD
; [[EUCLID (Ticagrelor)]]: New summary #290: Ticagrelor vs. clopidogrel in symptomatic PAD


==December 2016==
==December 2016==
; [[MUSTT]]: New summary #290: ICD and antiarrhythmics in mild HFrEF and NSVT
; [[MUSTT]]: New summary #289: ICD and antiarrhythmics in mild HFrEF and NSVT


; [[EXCEL]]: New summary #289: CABG vs. PCI in left main CAD
; [[EXCEL]]: New summary #288: CABG vs. PCI in left main CAD


; [[PIONEER AF-PCI]]: New summary #288: DOAC, VKA, antiplatelets after PCI with stent
; [[PIONEER AF-PCI]]: New summary #287: DOAC, VKA, antiplatelets after PCI with stent


; [[AIRTRIP]]: New summary #287: Anakinra in colchicine-resistant pericarditis
; [[AIRTRIP]]: New summary #286: Anakinra in colchicine-resistant pericarditis


==November 2016==
==November 2016==
; [[PESIT]]: New summary #286: Prevalence of PE in syncope
; [[PESIT]]: New summary #285: Prevalence of PE in syncope


; [[KEYNOTE-024]]: New summary #285: Pembrolizumab vs. chemotherapy in NSCLC
; [[KEYNOTE-024]]: New summary #284: Pembrolizumab vs. chemotherapy in NSCLC


; [[HYPRESS]]: New summary #284: Hydrocortisone in severe sepsis
; [[HYPRESS]]: New summary #283: Hydrocortisone in severe sepsis


==October 2016==
==October 2016==
; [[NORSTENT]]: New summary #283: Drug-eluting stent vs. bare-metal stent in CAD
; [[NORSTENT]]: New summary #282: Drug-eluting stent vs. bare-metal stent in CAD


; [[ISAR-TRIPLE]]: New summary #282: Triple therapy for 6w vs. 6m after DES
; [[ISAR-TRIPLE]]: New summary #281: Triple therapy for 6w vs. 6m after DES


; [[SOCRATES]]: New summary #281: Ticagrelor vs. aspirin in acute stroke or TIA
; [[SOCRATES]]: New summary #280: Ticagrelor vs. aspirin in acute stroke or TIA


==September 2016==
==September 2016==
Line 474: Line 477:
: '''Benjamin A. Weinberg, MD''' from Georgetown/Lombardi Cancer Center and '''Nirmal Choradia, MD''' from Georgetown/MedStar Montgomery Medical Center. Are you interested in becoming a WJC editor? [http://bit.ly/1JMUsAb Read more about the editorial positions.]
: '''Benjamin A. Weinberg, MD''' from Georgetown/Lombardi Cancer Center and '''Nirmal Choradia, MD''' from Georgetown/MedStar Montgomery Medical Center. Are you interested in becoming a WJC editor? [http://bit.ly/1JMUsAb Read more about the editorial positions.]


; [[AATAC]]: New summary #280: AF ablation vs. amiodarone in HFrEF with LVEF ≤40%
; [[AATAC]]: New summary #279: AF ablation vs. amiodarone in HFrEF with LVEF ≤40%


; [[DANISH]]: New summary #279: ICD vs. standard care in NICM and LVEF ≤35%
; [[DANISH]]: New summary #278: ICD vs. standard care in NICM and LVEF ≤35%


; [[LEADER]]: New summary #278: Liraglutide and CVD endpoints in T2DM
; [[LEADER]]: New summary #277: Liraglutide and CVD endpoints in T2DM


; [[RAFT]]: New summary #277: CRT+ICD for mild-moderate HFrEF
; [[RAFT]]: New summary #276: CRT+ICD for mild-moderate HFrEF


; [[PRODIGE 4 ACCORD 11]]: New summary #276: FOLFIRINOX in pancreatic cancer
; [[PRODIGE 4 ACCORD 11]]: New summary #275: FOLFIRINOX in pancreatic cancer


; [[HEARTMATE II]]: New summary #275: Continuous-flow LVAD in heart failure
; [[HEARTMATE II]]: New summary #274: Continuous-flow LVAD in heart failure


==August 2016==
==August 2016==
; [[MPACT]]: New summary #274: Gemcitabine/nab-paclitaxel in pancreatic cancer
; [[MPACT]]: New summary #273: Gemcitabine/nab-paclitaxel in pancreatic cancer


; [[SPAF]]: New summary #273: Aspirin and warfarin in AF
; [[SPAF]]: New summary #272: Aspirin and warfarin in AF


; [[DAVID]]: New summary #272: Dual-chamber vs. ventricular backup pacing in ICD patients
; [[DAVID]]: New summary #271: Dual-chamber vs. ventricular backup pacing in ICD patients


==July 2016==
==July 2016==
; Welcome, new medical students, interns, residents, and fellows!
; Welcome, new medical students, interns, residents, and fellows!


; [[MSH]]: New summary #271: Hydroxyurea in sickle-cell disease
; [[MSH]]: New summary #270: Hydroxyurea in sickle-cell disease


; [[ERSPC]]: New summary #270: PSA for prostate cancer screening
; [[ERSPC]]: New summary #269: PSA for prostate cancer screening


; [[FIRE AND ICE]]: New summary #269: Cryoablation vs. RF ablation in pAF
; [[FIRE AND ICE]]: New summary #268: Cryoablation vs. RF ablation in pAF


; [[COLONPREV]]: New summary #268: FIT vs. colonoscopy for colon cancer screening
; [[COLONPREV]]: New summary #267: FIT vs. colonoscopy for colon cancer screening


==June 2016==
==June 2016==
; [[VANISH]]: New summary #267: Ablation vs. antiarrhythmic drugs in VT
; [[VANISH]]: New summary #266: Ablation vs. antiarrhythmic drugs in VT


; [[OAT]]: New summary #266: PCI+OMT vs. OMT 3-28 days after MI
; [[OAT]]: New summary #265: PCI+OMT vs. OMT 3-28 days after MI


; [[SPS3 Clopidogrel-ASA]]: New summary #265: Clopidogrel+ASA for lacunar strokes
; [[SPS3 Clopidogrel-ASA]]: New summary #264: Clopidogrel+ASA for lacunar strokes


==May 2016==
==May 2016==
; [[PARTNER 2]]: New summary #264: TAVI for AS in intermediate-risk surgical candidates
; [[PARTNER 2]]: New summary #263: TAVI for AS in intermediate-risk surgical candidates


; [[PARTNER A]]: New summary #263: TAVI for AS in high-risk surgical candidates
; [[PARTNER A]]: New summary #262: TAVI for AS in high-risk surgical candidates


; [[TACTICS-TIMI 18]]: New summary #262: Early vs. Delayed PCI for UA-NSTEMI
; [[TACTICS-TIMI 18]]: New summary #261: Early vs. Delayed PCI for UA-NSTEMI


; [[SHIFT]]: New summary #261: Ivabradine in HFrEF
; [[SHIFT]]: New summary #260: Ivabradine in HFrEF


==April 2016==
==April 2016==
; [[FREEDOM]]: New summary #260: CABG vs. PCI for CAD in T2DM
; [[FREEDOM]]: New summary #259: CABG vs. PCI for CAD in T2DM


; [[DINAMIT]]: New summary #259: ICD for ICM shortly after MI
; [[DINAMIT]]: New summary #258: ICD for ICM shortly after MI


; [[NEAT-HFpEF]]: New summary #258: Nitrates for activity tolerance in HFpEF
; [[NEAT-HFpEF]]: New summary #257: Nitrates for activity tolerance in HFpEF


; [[CATIE-AD]]: New summary #257: Antipsychotics in dementia with psychosis
; [[CATIE-AD]]: New summary #256: Antipsychotics in dementia with psychosis


==March 2016==
==March 2016==
; [[SAMMPRIS]]: New summary #256: Stenting in intracranial stenosis
; [[SAMMPRIS]]: New summary #255: Stenting in intracranial stenosis


; [[STOPAH]]: New summary #255: Prednisolone vs. pentoxifylline in alcoholic hepatitis
; [[STOPAH]]: New summary #254: Prednisolone vs. pentoxifylline in alcoholic hepatitis


; [[PREPIC]]: New summary #254: IVC filters for proximal DVT
; [[PREPIC]]: New summary #253: IVC filters for proximal DVT


==February 2016==
==February 2016==
; [[CYTO-PV]]: New summary #253: Hematocrit thresholds in PV
; [[CYTO-PV]]: New summary #252: Hematocrit thresholds in PV


; [[Benazepril in Severe CKD]]: New summary #252: Benazepril in non-diabetic CKD
; [[Benazepril in Severe CKD]]: New summary #251: Benazepril in non-diabetic CKD


; 2016 Chest guidelines updated: Updates applied to [[AMPLIFY]], [[EINSTEIN-PE]], [[RE-COVER]], and other articles addressing antithrombotic therapy.
; 2016 Chest guidelines updated: Updates applied to [[AMPLIFY]], [[EINSTEIN-PE]], [[RE-COVER]], and other articles addressing antithrombotic therapy.


==January 2016==
==January 2016==
; [[RE-VERSE AD]]: New summary #251: Idarucizumab for dabigatran reversal
; [[RE-VERSE AD]]: New summary #250: Idarucizumab for dabigatran reversal


; [[INSIGHT START]]: New summary #250: Early vs. delayed ART in HIV
; [[INSIGHT START]]: New summary #249: Early vs. delayed ART in HIV


; [[IDNT]]: New summary #249: ARBs in diabetic nephropathy
; [[IDNT]]: New summary #248: ARBs in diabetic nephropathy


; [[SPS3-BP]]: New summary #248: SBP <130 vs. SBP 130-150 after lacunar strokes
; [[SPS3-BP]]: New summary #247: SBP <130 vs. SBP 130-150 after lacunar strokes


==December 2015==
==December 2015==
; [[PEGASUS-TIMI 54]]: New summary #247: Extended ticagrelor+ASA after MI
; [[PEGASUS-TIMI 54]]: New summary #246: Extended ticagrelor+ASA after MI


; [[Ibrutinib in Waldenstrom macroglobulinemia]]: New summary #246: Second-line ibrutinib in WM
; [[Ibrutinib in Waldenstrom macroglobulinemia]]: New summary #245: Second-line ibrutinib in WM


; [[ANRS IPERGAY]]: New summary #245: Pre-exposure prophylaxis in high-risk men
; [[ANRS IPERGAY]]: New summary #244: Pre-exposure prophylaxis in high-risk men


; Welcome New Editor!
; Welcome New Editor!
Line 563: Line 566:


==November 2015==
==November 2015==
; [[3SITES]]: New summary #244: Central line complications by insertion site
; [[3SITES]]: New summary #243: Central line complications by insertion site


; ZDoggMD! : Many thanks to [http://zdoggmd.com/ ZDoggMD] for having us as extras in his '''just released''' video, [http://zdoggmd.com/it-was-a-good-call-day/ It Was a Good Call Day]. It was an incredibly fun and funny shoot.   
; ZDoggMD! : Many thanks to [http://zdoggmd.com/ ZDoggMD] for having us as extras in his '''just released''' video, [http://zdoggmd.com/it-was-a-good-call-day/ It Was a Good Call Day]. It was an incredibly fun and funny shoot.   
Line 570: Line 573:
: '''Kevin Seitz''', MD/MSc candidate at Emory University, joins us as Deputy Editor of Pulmonology/Critical Care Medicine. And '''Jun Ng''', MBBS from the University of Queensland, comes aboard as Associate Editor of Endocrinology.  
: '''Kevin Seitz''', MD/MSc candidate at Emory University, joins us as Deputy Editor of Pulmonology/Critical Care Medicine. And '''Jun Ng''', MBBS from the University of Queensland, comes aboard as Associate Editor of Endocrinology.  


; [[SPRINT]]: New summary #243: BP targets in high-risk patients
; [[SPRINT]]: New summary #242: BP targets in high-risk patients


; [[FRISC-II]]: New summary #242: Early invasive strategy in UA/NSTEMI
; [[FRISC-II]]: New summary #241: Early invasive strategy in UA/NSTEMI


==October 2015==
==October 2015==
; [[EMPA-REG OUTCOME]]: New summary #241: Empagliflozin for CV outcomes in T2DM
; [[EMPA-REG OUTCOME]]: New summary #240: Empagliflozin for CV outcomes in T2DM


; [[MASS]]: New summary #240: US screening for AAA in men
; [[MASS]]: New summary #239: US screening for AAA in men


; Updated apps!: New Journal Club apps are here for iOS and Android! Now with favorites and slick-looking reference pop-ups. Head to [http://www.journalclubapp.com journalclubapp.com] and grab it for yourself!
; Updated apps!: New Journal Club apps are here for iOS and Android! Now with favorites and slick-looking reference pop-ups. Head to [http://www.journalclubapp.com journalclubapp.com] and grab it for yourself!


; [[EVOLVE]]: New summary #239: Cinacalcet in ESRD
; [[EVOLVE]]: New summary #238: Cinacalcet in ESRD


; [[ADJUST-PE]]: Updated guidelines.
; [[ADJUST-PE]]: Updated guidelines.


==September 2015==
==September 2015==
; [[COMET-ICE]]: New summary #238: Preop coronary revascularization if stable CAD
; [[COMET-ICE]]: New summary #237: Preop coronary revascularization if stable CAD


; [[CARP]]: New summary #237: Preop coronary revascularization if stable CAD
; [[CARP]]: New summary #236: Preop coronary revascularization if stable CAD


; [[ODYSSEY LONG TERM]]: New summary #236: PCSK9 inhibitor alirocumab for HLD
; [[ODYSSEY LONG TERM]]: New summary #235: PCSK9 inhibitor alirocumab for HLD


; [[Stopping Statins at the End of Life]]: New summary #235: Palliative statin discontinuation
; [[Stopping Statins at the End of Life]]: New summary #234: Palliative statin discontinuation


; JGME Editorial: [http://bit.ly/1UrutR1 Read all about Wiki Journal Club], the website that powers the Journal Club app
; JGME Editorial: [http://bit.ly/1UrutR1 Read all about Wiki Journal Club], the website that powers the Journal Club app


==August 2015==
==August 2015==
; [[FLAME (Stroke)]]: New summary #234: SSRI after CVA for motor recovery
; [[FLAME (Stroke)]]: New summary #233: SSRI after CVA for motor recovery


; [[ECST]]: New summary #233: CEA in symptomatic carotid stenosis
; [[ECST]]: New summary #232: CEA in symptomatic carotid stenosis


; [[ACT]]: New summary #232: Acetylcysteine with IV contrast
; [[ACT]]: New summary #231: Acetylcysteine with IV contrast


; [[PARTNER B]]: Added 5 year follow-up outcomes
; [[PARTNER B]]: Added 5 year follow-up outcomes
Line 611: Line 614:


==July 2015==
==July 2015==
; [[BRIDGE]]: New summary #231: LMWH bridging for surgery in AF
; [[BRIDGE]]: New summary #230: LMWH bridging for surgery in AF


; [[PREPIC 2]]: New summary #230: IVC filters for high-risk PE
; [[PREPIC 2]]: New summary #229: IVC filters for high-risk PE


; [[ASCEND]]: Added new IPF guidelines
; [[ASCEND]]: Added new IPF guidelines


; [[BRIM-3]]: New summary #229: Vemurafenib in BRAF V600+ melanoma
; [[BRIM-3]]: New summary #228: Vemurafenib in BRAF V600+ melanoma


; Welcome to our new associate editors!
; Welcome to our new associate editors!
Line 625: Line 628:


==June 2015==
==June 2015==
; [[CHARM-Preserved]]: New summary #228: ARBs in HFpEF
; [[CHARM-Preserved]]: New summary #227: ARBs in HFpEF


; [[COGENT]]
; [[COGENT]]
: Added systematic review and expanded criticisms
: Added systematic review and expanded criticisms


; [[WOEST]]: New summary #227: Clopidogrel ± ASA after PCI if on OAC
; [[WOEST]]: New summary #226: Clopidogrel ± ASA after PCI if on OAC


; Welcome to our first associate editor!
; Welcome to our first associate editor!
: Lily Zhou, MD from University of Ottawa is joining the WJC team as Associate Editor of Neurology.  
: Lily Zhou, MD from University of Ottawa is joining the WJC team as Associate Editor of Neurology.  


; [[IMPROVE-IT]]: New summary #226: Ezetimibe+simvastatin after ACS
; [[IMPROVE-IT]]: New summary #225: Ezetimibe+simvastatin after ACS


; Welcome to our first deputy editor!
; Welcome to our first deputy editor!
Line 647: Line 650:


==May 2015==
==May 2015==
; [[ADJUST-PE]]: New summary #225: Age-adjusted D-dimer for PE
; [[ADJUST-PE]]: New summary #224: Age-adjusted D-dimer for PE


; [[WISDOM]]: New summary #224: ICS withdrawal in COPD
; [[WISDOM]]: New summary #223: ICS withdrawal in COPD


; [[MR RESCUE]]: New summary #223: Thrombectomy vs. standard care in stroke
; [[MR RESCUE]]: New summary #222: Thrombectomy vs. standard care in stroke


==April 2015==
==April 2015==
; [[Can-SAD]]: New summary #222: Light therapy vs. SSRI for SAD
; [[Can-SAD]]: New summary #221: Light therapy vs. SSRI for SAD


; Technical Update
; Technical Update
Line 661: Line 664:
; Society of General Internal Medicine conference in Toronto: Come say hello and check out our poster (''Journal Club mobile app usage in developing and developed countries'') on Thursday, April 23 at 11:30AM at poster session #2!
; Society of General Internal Medicine conference in Toronto: Come say hello and check out our poster (''Journal Club mobile app usage in developing and developed countries'') on Thursday, April 23 at 11:30AM at poster session #2!


; [[HYVET]]: New summary #221: Elderly HTN treatment
; [[HYVET]]: New summary #220: Elderly HTN treatment


==March 2015==
==March 2015==
; [[ATN]]: New summary #220: RRT intensity in ATN
; [[ATN]]: New summary #219: RRT intensity in ATN


; [[ASCEND]]: Updated to include detailed discussion of survival endpoints, with attention to progression-free survival and overall survival.
; [[ASCEND]]: Updated to include detailed discussion of survival endpoints, with attention to progression-free survival and overall survival.


; [[BASALT]]: New summary #219: Symptom-based asthma therapy
; [[BASALT]]: New summary #218: Symptom-based asthma therapy


; [[HS troponin-T to rule out MI]]: New summary #218: High sensitivity troponin for acute chest pain
; [[HS troponin-T to rule out MI]]: New summary #217: High sensitivity troponin for acute chest pain


; [[CYCLOPS]]: New summary #217: Pulse cyclophosphamide for ANCA vasculitis
; [[CYCLOPS]]: New summary #216: Pulse cyclophosphamide for ANCA vasculitis


; [[StiL]]: Updated to mention the ongoing [[ECOG 2408]] study of maintenance rituximab +/- lenalidomide.
; [[StiL]]: Updated to mention the ongoing [[ECOG 2408]] study of maintenance rituximab +/- lenalidomide.


==February 2015==
==February 2015==
; [[ELITE-Symphony]]: New summary #216: Immunosuppression after kidney transplant
; [[ELITE-Symphony]]: New summary #215: Immunosuppression after kidney transplant


; [[ORIGIN n-3 Fatty Acids]]: New summary #215: Fish oil for high-risk CVD
; [[ORIGIN n-3 Fatty Acids]]: New summary #214: Fish oil for high-risk CVD


; [[HPS2-THRIVE]]: New summary #214: Niacin in atherosclerotic disease
; [[HPS2-THRIVE]]: New summary #213: Niacin in atherosclerotic disease


==January 2015==
==January 2015==
; [[TALC]]: New summary #213: Tiotropium vs. others in asthma
; [[TALC]]: New summary #212: Tiotropium vs. others in asthma


; [[Age Trial]]: New summary #212: Mammograms for 40-49 year old women
; [[Age Trial]]: New summary #211: Mammograms for 40-49 year old women


; [[STAMPEDE]]: New summary #211: Gastric bypass vs. medical therapy for T2DM
; [[STAMPEDE]]: New summary #210: Gastric bypass vs. medical therapy for T2DM


; [[Cytisine for Smoking Cessation]]: New summary #210: Cytisine vs. NRT for tobacco abuse
; [[Cytisine for Smoking Cessation]]: New summary #209: Cytisine vs. NRT for tobacco abuse


==December 2014==
==December 2014==
; [[VALENCE]]: New summary #209: Sofosbuvir+ribavirin for HCV genotypes 2 or 3
; [[VALENCE]]: New summary #208: Sofosbuvir+ribavirin for HCV genotypes 2 or 3


; [[TRISS]]: New summary #208: Transfusion thresholds in sepsis
; [[TRISS]]: New summary #207: Transfusion thresholds in sepsis


; [[Lo-Coco 2013]]: New summary #207: ATRA-ATO vs. ATRA-chemotherapy in APL
; [[Lo-Coco 2013]]: New summary #206: ATRA-ATO vs. ATRA-chemotherapy in APL


==November 2014==
==November 2014==
; [[BeSt]]: Updated ACR RA guidelines
; [[BeSt]]: Updated ACR RA guidelines


; [[FEAST]]: New summary #206: Fluid resuscitation in Sub-Saharan Africa
; [[FEAST]]: New summary #205: Fluid resuscitation in Sub-Saharan Africa


; [[DAPT]]: New summary #205: Aspirin/clopidogrel duration after PCI
; [[DAPT]]: New summary #204: Aspirin/clopidogrel duration after PCI


; [[NA-ACCORD]]: New summary #204: Early vs. delayed ART in HIV
; [[NA-ACCORD]]: New summary #203: Early vs. delayed ART in HIV


; [[AZT Trial]], [[HPTN 052]], [[IPrEx]]: Updated HIV treatment and prevention guidelines
; [[AZT Trial]], [[HPTN 052]], [[IPrEx]]: Updated HIV treatment and prevention guidelines


; [[ARISE]]: New summary #203: EGDT vs. usual care in sepsis
; [[ARISE]]: New summary #202: EGDT vs. usual care in sepsis


==October 2014==
==October 2014==
Line 717: Line 720:
; [[ALBIOS]], [[SAFE]]: Surviving Sepsis Campaign guidelines have been added. (These guidelines have not yet been updated to reflect the results of the [[CRISTAL]] study.)
; [[ALBIOS]], [[SAFE]]: Surviving Sepsis Campaign guidelines have been added. (These guidelines have not yet been updated to reflect the results of the [[CRISTAL]] study.)


; [[CHARISMA]]: New summary #202: Aspirin/clopidogrel vs. aspirin for CV prevention
; [[CHARISMA]]: New summary #201: Aspirin/clopidogrel vs. aspirin for CV prevention


; [[CATT]]: New summary #201: Ranibizumab vs. bevacizumab for macular degeneration
; [[CATT]]: New summary #200: Ranibizumab vs. bevacizumab for macular degeneration


; [[CHOICE]]: New summary #200: Free long-acting reversible contraception in teens
; [[CHOICE]]: New summary #199: Free long-acting reversible contraception in teens


; [[CheckMate-003]]: New summary #199: Nivolumab in solid tumors
; [[CheckMate-003]]: New summary #198: Nivolumab in solid tumors


==September 2014==
==September 2014==
; [[COMMIT]], [[CURE]], [[ESSENCE]], [[GISSI-3]], [[GUSTO]], [[ISIS-2]], [[MIRACL]], [[PLATO]], [[PROVE IT-TIMI 22]], [[SAVE]], [[TRITON-TIMI 38]], [[VA Cooperative Study]], and [[VALIANT]]: Updated NSTE-ACS guidelines
; [[COMMIT]], [[CURE]], [[ESSENCE]], [[GISSI-3]], [[GUSTO]], [[ISIS-2]], [[MIRACL]], [[PLATO]], [[PROVE IT-TIMI 22]], [[SAVE]], [[TRITON-TIMI 38]], [[VA Cooperative Study]], and [[VALIANT]]: Updated NSTE-ACS guidelines


; [[GUSTO]]: New summary #198: tPA in ACS
; [[GUSTO]]: New summary #197: tPA in ACS


; [[Hungarian Prenatal Vitamin Trial]]: New summary #197: Perinatal vitamins to prevent neural tube defects
; [[Hungarian Prenatal Vitamin Trial]]: New summary #196: Perinatal vitamins to prevent neural tube defects


; [[PARADIGM-HF]]: New summary #196: ARNI vs. enalapril in HFrEF
; [[PARADIGM-HF]]: New summary #195: ARNI vs. enalapril in HFrEF


==August 2014==
==August 2014==
; [[CHARM-Added]]: New summary #195: ARB plus ACE-I in HF
; [[CHARM-Added]]: New summary #194: ARB plus ACE-I in HF


; [[ACCORD BP]]: New summary #194: Intensive BP control in T2DM
; [[ACCORD BP]]: New summary #193: Intensive BP control in T2DM


; [[COMMIT]]: Update: ACS guidelines
; [[COMMIT]]: Update: ACS guidelines


; [[VASST]]: New summary #193: Vasopressin in septic shock
; [[VASST]]: New summary #192: Vasopressin in septic shock


; Taking the boards!: August additions coming in the second half of the month.
; Taking the boards!: August additions coming in the second half of the month.
Line 749: Line 752:


==July 2014==
==July 2014==
; [[ASCEND (IPF)]]: New summary #192: Pirfenidone in IPF
; [[ASCEND (IPF)]]: New summary #191: Pirfenidone in IPF


; [[CRISTAL]]: New summary #191: Colloids vs. crystalloids in shock
; [[CRISTAL]]: New summary #190: Colloids vs. crystalloids in shock


; [[Prednisolone in Severe Alcoholic Hepatitis]] and [[Pentoxifylline in Severe Alcoholic Hepatitis]]: Update: Added AASLD/ACG guidelines
; [[Prednisolone in Severe Alcoholic Hepatitis]] and [[Pentoxifylline in Severe Alcoholic Hepatitis]]: Update: Added AASLD/ACG guidelines


; [[SONIC]]: New summary #190: Infliximab ± azathioprine induction in Crohn disease
; [[SONIC]]: New summary #189: Infliximab ± azathioprine induction in Crohn disease


; [[LESS]]: New summary #189: Epidural steroids in spinal stenosis
; [[LESS]]: New summary #188: Epidural steroids in spinal stenosis


; [[ASCEND]]: New summary #188: Pirfenidone in IPF
; [[ASCEND]]: New summary #187: Pirfenidone in IPF


==June 2014==
==June 2014==
; [[RED-HF]]: New summary #187: Darbepoetin in HFrEF
; [[RED-HF]]: New summary #186: Darbepoetin in HFrEF


; [[ORBIT-AF]]: New summary #186: ASA/warfarin vs. warfarin in AF
; [[ORBIT-AF]]: New summary #185: ASA/warfarin vs. warfarin in AF


; [[SWOG 8949]]: New summary #185: Cytoreductive nephrectomy in metastatic RCC
; [[SWOG 8949]]: New summary #184: Cytoreductive nephrectomy in metastatic RCC


; [[A-HeFT]], [[CARRESS-HF]], [[COMET]], [[CONSENSUS]], [[COPERNICUS]], [[CORONA]], [[DEFINITE]], [[DIG]], [[DOSE]], [[EMPHASIS-HF]], [[EPHESUS]], [[ESCAPE]], [[EVEREST-Outcomes]], [[MADIT-CRT]], [[MADIT-II]], [[MERIT-HF]], [[RALES]], [[SAVE]], [[SCD-HeFT]], [[SOLVD]], [[STICH]], [[V-HeFT]], [[Val-HeFT]]: Updated HF guidelines
; [[A-HeFT]], [[CARRESS-HF]], [[COMET]], [[CONSENSUS]], [[COPERNICUS]], [[CORONA]], [[DEFINITE]], [[DIG]], [[DOSE]], [[EMPHASIS-HF]], [[EPHESUS]], [[ESCAPE]], [[EVEREST-Outcomes]], [[MADIT-CRT]], [[MADIT-II]], [[MERIT-HF]], [[RALES]], [[SAVE]], [[SCD-HeFT]], [[SOLVD]], [[STICH]], [[V-HeFT]], [[Val-HeFT]]: Updated HF guidelines


; [[StiL]]: New summary #184: BR vs. R-CHOP for indolent lymphomas
; [[StiL]]: New summary #183: BR vs. R-CHOP for indolent lymphomas


==May 2014==
==May 2014==
; [[PLACIDE]]: New summary #183: Probiotics to prevent CDAD
; [[PLACIDE]]: New summary #182: Probiotics to prevent CDAD


; [[VA-NEPHRON D]]: New summary #182: ACE+ARB in DM nephropathy
; [[VA-NEPHRON D]]: New summary #181: ACE+ARB in DM nephropathy


; [[RACE II]], [[AFFIRM]], [[ACTIVE A]], [[ACTIVE W]], [[RE-ALIGN]], [[ROCKET AF]], [[AVERROES]], [[ARISTOTLE]], [[RE-LY]]: Updated AF guidelines  
; [[RACE II]], [[AFFIRM]], [[ACTIVE A]], [[ACTIVE W]], [[RE-ALIGN]], [[ROCKET AF]], [[AVERROES]], [[ARISTOTLE]], [[RE-LY]]: Updated AF guidelines  


; [[TOPCAT]]: New summary #181: Spironolactone for HFpEF
; [[TOPCAT]]: New summary #180: Spironolactone for HFpEF


; [[ONTARGET]]: New summary #180: Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM
; [[ONTARGET]]: New summary #179: Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM


==April 2014==
==April 2014==
; [[POISE-2 ASA]]: New summary #179: Perioperative ASA
; [[POISE-2 ASA]]: New summary #178: Perioperative ASA


; [[PEITHO]]: New summary #178: tPA for submassive PE
; [[PEITHO]]: New summary #177: tPA for submassive PE


; [[SEPSISPAM]]: New summary #177: MAP 65-70 vs. 80-85 mmHg in sepsis
; [[SEPSISPAM]]: New summary #176: MAP 65-70 vs. 80-85 mmHg in sepsis


; [[MADIT-CRT]]: New summary #176: CRT in HFrEF with QRS ≥130 msec and mild symptoms
; [[MADIT-CRT]]: New summary #175: CRT in HFrEF with QRS ≥130 msec and mild symptoms


==March 2014==
==March 2014==
; [[ALBIOS]]: New summary #175: Daily albumin in severe sepsis
; [[ALBIOS]]: New summary #174: Daily albumin in severe sepsis


; [[ProCESS]]: New summary #174: EGDT in septic shock
; [[ProCESS]]: New summary #173: EGDT in septic shock


; [[TTM]]: New summary #173: 33 vs. 36°C body temperature after cardiac arrest
; [[TTM]]: New summary #172: 33 vs. 36°C body temperature after cardiac arrest


; [[Rifaximin and Lactulose for HE]]: New summary #172: Rifaximin/lactulose vs. lactulose for acute HE
; [[Rifaximin and Lactulose for HE]]: New summary #171: Rifaximin/lactulose vs. lactulose for acute HE


==February 2014==
==February 2014==
; [[MOPETT]]: New summary #171: Low-dose tPA for submassive PE
; [[MOPETT]]: New summary #170: Low-dose tPA for submassive PE


; [[PCPT]]: New summary #170: Finasteride for prostate cancer prophylaxis
; [[PCPT]]: New summary #169: Finasteride for prostate cancer prophylaxis


; [[MIDA]]: New summary #169: Early surgery for MR
; [[MIDA]]: New summary #168: Early surgery for MR


==January 2014==
==January 2014==
; [[NOTT]]: New summary #168: Continuous vs. nocturnal oxygen in COPD
; [[NOTT]]: New summary #167: Continuous vs. nocturnal oxygen in COPD


; [[AZT Trial]]: New summary #167: Zidovudine in HIV/AIDS
; [[AZT Trial]]: New summary #166: Zidovudine in HIV/AIDS


; [[PARAMOUNT]]: New summary #166: Maintenance pemetrexed in lung cancer
; [[PARAMOUNT]]: New summary #165: Maintenance pemetrexed in lung cancer


; [[UKPDS 34]]: New summary #165: Metformin in T2DM
; [[UKPDS 34]]: New summary #164: Metformin in T2DM


; [[ICAP]]: New summary #164: Colchicine in the first episode of acute pericarditis
; [[ICAP]]: New summary #163: Colchicine in the first episode of acute pericarditis


==December 2013==
==December 2013==
; [[Twice-daily RT for SCLC]]: New summary #163: Twice-daily RT in limited SCLC
; [[Twice-daily RT for SCLC]]: New summary #162: Twice-daily RT in limited SCLC


; [[PARTNER B]]: New summary #162: TAVI for AS in poor surgical candidates
; [[PARTNER B]]: New summary #161: TAVI for AS in poor surgical candidates


; [[TNT]]: New summary #161: Atorvastatin in stable CAD
; [[TNT]]: New summary #160: Atorvastatin in stable CAD


==November 2013==
==November 2013==
; [[ESPRIT]]: New summary #160: ASA+dipyridamole in secondary stroke prevention
; [[ESPRIT]]: New summary #159: ASA+dipyridamole in secondary stroke prevention


; [[PRAMI]]: New summary #159: PCI to high-risk non-infarct arteries in STEMI
; [[PRAMI]]: New summary #158: PCI to high-risk non-infarct arteries in STEMI


; [[SYNTAX]]: Update: Added ACCF/AHA guidelines  
; [[SYNTAX]]: Update: Added ACCF/AHA guidelines  


; [[AVERROES]]: New summary #158: Apixaban vs. ASA in AF
; [[AVERROES]]: New summary #157: Apixaban vs. ASA in AF


==October 2013==
==October 2013==
; [[MAGELLAN]]: New summary #157: Rivaroxaban vs. LMWH for VTE prophylaxis
; [[MAGELLAN]]: New summary #156: Rivaroxaban vs. LMWH for VTE prophylaxis


; [[RE-ALIGN]]: New summary #156: Dabigatran in mechanical heart valves
; [[RE-ALIGN]]: New summary #155: Dabigatran in mechanical heart valves


; [[EXTRA]]: New summary #155: Omalizumab in severe allergic asthma
; [[EXTRA]]: New summary #154: Omalizumab in severe allergic asthma


; [[HERA]]: Update: Added follow-up data demonstrating similar efficacy but increased cardiotoxicity of 2 years of trastuzumab compared to 1 year.
; [[HERA]]: Update: Added follow-up data demonstrating similar efficacy but increased cardiotoxicity of 2 years of trastuzumab compared to 1 year.


; [[ATLAS]]: New summary #154: 10y vs. 5y tamoxifen in breast cancer
; [[ATLAS]]: New summary #153: 10y vs. 5y tamoxifen in breast cancer


; [[GI bleeding in ICU patients]]: New summary #153: Risk factors for GI bleeds in ICU patients
; [[GI bleeding in ICU patients]]: New summary #152: Risk factors for GI bleeds in ICU patients


==September 2013==
==September 2013==
; [[REDUCE]]: New summary #152: 5d vs. 14d steroids in acute COPD
; [[REDUCE]]: New summary #151: 5d vs. 14d steroids in acute COPD


; [[ASTRAL]]: New summary #151: Revascularization in RAS
; [[ASTRAL]]: New summary #150: Revascularization in RAS


; [[METEOR]]: New summary #150: Surgery vs. PT in OA with meniscal tear
; [[METEOR]]: New summary #149: Surgery vs. PT in OA with meniscal tear


; [[Look AHEAD]]: New summary #149: Weight loss and exercise in T2DM
; [[Look AHEAD]]: New summary #148: Weight loss and exercise in T2DM


; [[PLATO]]: New summary #148: Ticagrelor vs. clopidogrel in ACS
; [[PLATO]]: New summary #147: Ticagrelor vs. clopidogrel in ACS


; [[OSCILLATE]]: New summary #147: High-frequency oscillatory vent in early ARDS
; [[OSCILLATE]]: New summary #146: High-frequency oscillatory vent in early ARDS


; [[STAR-D]]: New summary #146: Tiered approach for depression
; [[STAR-D]]: New summary #145: Tiered approach for depression


==August 2013==
==August 2013==
; [[LoDoCo]]: New summary #145: Colchicine for stable CAD
; [[LoDoCo]]: New summary #144: Colchicine for stable CAD


; [[AMPLIFY]]: New summary #144: Apixaban vs. warfarin in VTE
; [[AMPLIFY]]: New summary #143: Apixaban vs. warfarin in VTE


; [[NETT]]: New summary #143: Lung volume reduction in COPD
; [[NETT]]: New summary #142: Lung volume reduction in COPD


; [[CSG Captopril Trial]]: New summary #142: Captopril in T1DM nephropathy
; [[CSG Captopril Trial]]: New summary #141: Captopril in T1DM nephropathy


; [[4S]]: New summary #141: Simvastatin in stable CAD
; [[4S]]: New summary #140: Simvastatin in stable CAD


; [[ASPIRE]]: New summary #140: Aspirin after VTE treatment
; [[ASPIRE]]: New summary #139: Aspirin after VTE treatment


; [[Daily ICU Sedation Holidays]]: New summary #139: Scheduled daily sedation holidays in intubated patients
; [[Daily ICU Sedation Holidays]]: New summary #138: Scheduled daily sedation holidays in intubated patients


==July 2013==
==July 2013==
; [[Duct Tape for Treatment of the Common Wart]]: New summary #138: Duct tape vs. cryotherapy for warts
; [[Duct Tape for Treatment of the Common Wart]]: New summary #137: Duct tape vs. cryotherapy for warts


; [[EINSTEIN-PE]]: New summary #137: Rivaroxaban vs. warfarin in PE
; [[EINSTEIN-PE]]: New summary #136: Rivaroxaban vs. warfarin in PE


; [[WHI]]: New summary #136: Postmenopausal estrogen/progesterone
; [[WHI]]: New summary #135: Postmenopausal estrogen/progesterone


; [[CHANCE]]: New summary #135: ASA/clopidogrel vs. ASA in TIA/stroke
; [[CHANCE]]: New summary #134: ASA/clopidogrel vs. ASA in TIA/stroke


; [[CRASH-2]]: New summary #134: Tranexamic acid in trauma
; [[CRASH-2]]: New summary #133: Tranexamic acid in trauma


; [[NCDS]]: New summary #133: Dialysis prescriptions in ESRD
; [[NCDS]]: New summary #132: Dialysis prescriptions in ESRD


==June 2013==
==June 2013==
; [[BARI 2D]]: New summary #132: CABG/PCI vs. OMT in diabetes with CAD
; [[BARI 2D]]: New summary #131: CABG/PCI vs. OMT in diabetes with CAD


; [[ARISTOTLE]]: New summary #131: Apixaban vs. warfarin in AF
; [[ARISTOTLE]]: New summary #130: Apixaban vs. warfarin in AF


; [[ESCAPE]]: New summary #130: PA catheters in acute HF management
; [[ESCAPE]]: New summary #129: PA catheters in acute HF management


; [[PROSEVA]]: New summary #129: Prone ventilation in ARDS
; [[PROSEVA]]: New summary #128: Prone ventilation in ARDS


; [[PREDIMED]]: New summary #128: Mediterranean diet in CVD prevention
; [[PREDIMED]]: New summary #127: Mediterranean diet in CVD prevention


; [[EVEREST-Outcomes]]: New summary #127: Tolvaptan in acute HF in HFrEF
; [[EVEREST-Outcomes]]: New summary #126: Tolvaptan in acute HF in HFrEF


; [[ACURASYS]]: New summary #126: Cisatracurium in ARDS
; [[ACURASYS]]: New summary #125: Cisatracurium in ARDS


; [[DOSE]]: New summary #125: Diuretic dosing in acute HF
; [[DOSE]]: New summary #124: Diuretic dosing in acute HF


; [[ACCOMPLISH]]: New summary #124: Benazepril/amlodipine vs. benazepril/HCTZ in HTN
; [[ACCOMPLISH]]: New summary #123: Benazepril/amlodipine vs. benazepril/HCTZ in HTN


==May 2013==
==May 2013==
; [[CARRESS-HF]]: New summary #123: Ultrafiltration in decompensated HF
; [[CARRESS-HF]]: New summary #122: Ultrafiltration in decompensated HF


; [[COMMIT]]: New summary #122: Metoprolol in acute MI
; [[COMMIT]]: New summary #121: Metoprolol in acute MI


; [[RESPECT]]: New summary #121: PFO closure in cryptogenic stroke
; [[RESPECT]]: New summary #120: PFO closure in cryptogenic stroke


; [[ESSENCE]]: New summary #120: LMWH vs. UFH in UA/NSTEMI
; [[ESSENCE]]: New summary #119: LMWH vs. UFH in UA/NSTEMI


; [[ACTIVE W]]: New summary #119: ASA/clopidogrel vs. warfarin in AF
; [[ACTIVE W]]: New summary #118: ASA/clopidogrel vs. warfarin in AF


; [[AMPLIFY-EXT]]: New summary #118: Apixaban after VTE treatment
; [[AMPLIFY-EXT]]: New summary #117: Apixaban after VTE treatment


==April 2013==
==April 2013==
; [[TRITON-TIMI 38]]: New summary #117: Prasugrel vs. clopidogrel in ACS
; [[TRITON-TIMI 38]]: New summary #116: Prasugrel vs. clopidogrel in ACS


; [[MATCH]]: New summary #116: ASA/clopidogrel vs. clopidogrel in stroke
; [[MATCH]]: New summary #115: ASA/clopidogrel vs. clopidogrel in stroke


; [[ROCKET AF]]: New summary #115: Rivaroxaban vs. warfarin in AF
; [[ROCKET AF]]: New summary #114: Rivaroxaban vs. warfarin in AF


; [[TRICC]]: Update: Added transfusion guidelines  
; [[TRICC]]: Update: Added transfusion guidelines  


; [[PROVE IT-TIMI 22]]: New summary #114: Pravastatin vs. atorvastatin after ACS
; [[PROVE IT-TIMI 22]]: New summary #113: Pravastatin vs. atorvastatin after ACS


; [[EMILIA]]: New summary #113: T-DM1 in metastatic breast cancer
; [[EMILIA]]: New summary #112: T-DM1 in metastatic breast cancer


==March 2013==
==March 2013==
; [[COMET]]: Update: Added criticisms regarding dosage target in metoprolol control arm, as well as choosing metoprolol tartrate rather than standard-of-care metoprolol succinate.
; [[COMET]]: Update: Added criticisms regarding dosage target in metoprolol control arm, as well as choosing metoprolol tartrate rather than standard-of-care metoprolol succinate.


; [[ATLAS ACS-2, TIMI 51]]: New summary #112: Rivaroxaban after ACS
; [[ATLAS ACS-2, TIMI 51]]: New summary #111: Rivaroxaban after ACS


; [[WARFASA]]: New summary #111: Aspirin after VTE treatment
; [[WARFASA]]: New summary #110: Aspirin after VTE treatment


==February 2013==
==February 2013==
; [[Annane Trial]]: New summary #110: Corticosteroids in septic shock
; [[Annane Trial]]: New summary #109: Corticosteroids in septic shock


; [[RAVE]]: New summary #109: Rituximab vs. cyclophosphamide in ANCA-associated vasculitis
; [[RAVE]]: New summary #108: Rituximab vs. cyclophosphamide in ANCA-associated vasculitis


; [[IPrEx]]: New summary #108: ART in primary HIV prevention
; [[IPrEx]]: New summary #107: ART in primary HIV prevention


; [[Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile]]: New summary #107: Fecal transplant in C. difficile
; [[Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile]]: New summary #106: Fecal transplant in C. difficile


; [[NSABP B-32]]: New summary #106: Sentinel LN biopsy in breast cancer
; [[NSABP B-32]]: New summary #105: Sentinel LN biopsy in breast cancer


; [[Transfusion Strategies for Acute Upper Gastrointestinal Bleeding]]: New summary #105: Transfusion thresholds in UGIB
; [[Transfusion Strategies for Acute Upper Gastrointestinal Bleeding]]: New summary #104: Transfusion thresholds in UGIB


==January 2013==
==January 2013==
; [[Rivers Trial]]: Updates: More on the disagreement over using transfusion to hematocrit >30% for maintaining ScvO<sub>2</sub>, when studies like [[TRICC]] support a more restrictive transfusion strategy. Also, added the baseline characteristics of study participants.
; [[Rivers Trial]]: Updates: More on the disagreement over using transfusion to hematocrit >30% for maintaining ScvO<sub>2</sub>, when studies like [[TRICC]] support a more restrictive transfusion strategy. Also, added the baseline characteristics of study participants.


; [[Yang-Tobin Study]]: New summary #104: RSBI for predicting weaning
; [[Yang-Tobin Study]]: New summary #103: RSBI for predicting weaning


; [[RENAAL]]: New summary #103: ARBs in diabetic nephropathy
; [[RENAAL]]: New summary #102: ARBs in diabetic nephropathy


; [[CLOSURE I]]: New summary #102: PFO closure in cryptogenic stroke
; [[CLOSURE I]]: New summary #101: PFO closure in cryptogenic stroke


==December 2012==
==December 2012==
; [[STICH]]: New summary #101: CABG in ischemic HFrEF
; [[STICH]]: New summary #100: CABG in ischemic HFrEF


; [[CURE]]: New summary #100: Clopidogrel in UA/NSTEMI
; [[CURE]]: New summary #99: Clopidogrel in UA/NSTEMI


; [[CAST I]]: New summary #99: Antiarrhythmics post-MI
; [[CAST I]]: New summary #98: Antiarrhythmics post-MI


; [[V-HeFT]]: New summary #98: ISDN/hydralazine in HFrEF
; [[V-HeFT]]: New summary #97: ISDN/hydralazine in HFrEF


==November 2012==
==November 2012==
; [[PRoFESS]]: New summary #97: ASA-dipyridamole vs. clopidogrel in stroke
; [[PRoFESS]]: New summary #96: ASA-dipyridamole vs. clopidogrel in stroke


; [[IRIS]]: New summary #96: Imatinib vs. IFNα/cytarabine in CML
; [[IRIS]]: New summary #95: Imatinib vs. IFNα/cytarabine in CML


; [[FAME 2]]: New summary #95: FFR-guided PCI vs. OMT in CAD
; [[FAME 2]]: New summary #94: FFR-guided PCI vs. OMT in CAD


; [[Moseley Trial]]: New summary #94: Arthroscopy in knee OA
; [[Moseley Trial]]: New summary #93: Arthroscopy in knee OA


==October 2012==
==October 2012==
; [[NSABP P-1]]: New summary #93: Tamoxifen in breast cancer prevention
; [[NSABP P-1]]: New summary #92: Tamoxifen in breast cancer prevention


; [[HPTN 052]]: New summary #92: Early ART in HIV
; [[HPTN 052]]: New summary #91: Early ART in HIV


; [[FAME]]: New summary #91: FFR-guided PCI in stable CAD
; [[FAME]]: New summary #90: FFR-guided PCI in stable CAD


; [[NLST]]: New summary #90: CT vs. CXR in lung cancer screening
; [[NLST]]: New summary #89: CT vs. CXR in lung cancer screening


; [[IDEAL]]: New summary #89: Early vs. late dialysis in CKD
; [[IDEAL]]: New summary #88: Early vs. late dialysis in CKD


==September 2012==
==September 2012==
; [[PROWESS-SHOCK]]: New summary #88: Activated protein C in septic shock
; [[PROWESS-SHOCK]]: New summary #87: Activated protein C in septic shock


; [[PROWESS]]: New summary #87: Activated protein C in severe sepsis
; [[PROWESS]]: New summary #86: Activated protein C in severe sepsis


==August 2012==
==August 2012==
; [[STAR]]: New summary #86: Tamoxifen vs. raloxifene in breast cancer prevention
; [[STAR]]: New summary #85: Tamoxifen vs. raloxifene in breast cancer prevention


; [[POISE]]: Update: Now reflects a major criticism of the trial, namely the high-doses of long-acting metoprolol used in the immediate preoperative period, which may have led to more strokes and deaths in the metoprolol group
; [[POISE]]: Update: Now reflects a major criticism of the trial, namely the high-doses of long-acting metoprolol used in the immediate preoperative period, which may have led to more strokes and deaths in the metoprolol group


; [[RE-COVER]]: New summary #85: Dabigatran vs. warfarin in VTE
; [[RE-COVER]]: New summary #84: Dabigatran vs. warfarin in VTE


; [[SMART]]: New summary #84: Salmeterol in asthma
; [[SMART]]: New summary #83: Salmeterol in asthma


; [[GISSI-3]]: Update: Now reflects the 2004 ACC/AHA recommendation for ACE inhibitors or ARBs in all post-STEMI patients
; [[GISSI-3]]: Update: Now reflects the 2004 ACC/AHA recommendation for ACE inhibitors or ARBs in all post-STEMI patients


; [[EMPHASIS-HF]]: New summary #83: Eplerenone in HFrEF
; [[EMPHASIS-HF]]: New summary #82: Eplerenone in HFrEF


; [[PREVENT TB]]: New summary #82: Rifapentine/isoniazid in latent TB
; [[PREVENT TB]]: New summary #81: Rifapentine/isoniazid in latent TB


==July 2012==
==July 2012==
; [[CORONA]]: New summary #81: Rosuvastatin in ischemic HFrEF
; [[CORONA]]: New summary #80: Rosuvastatin in ischemic HFrEF


; [[CREST]]: Update: Now reflects the 2011 ACC/AHA guidelines on carotid artery stenting
; [[CREST]]: Update: Now reflects the 2011 ACC/AHA guidelines on carotid artery stenting
Line 1,024: Line 1,027:


==June 2012==
==June 2012==
; [[CATIE]]: New summary #80: Antipsychotics in schizophrenia
; [[CATIE]]: New summary #79: Antipsychotics in schizophrenia


; [[SYNTAX]]: New summary #79: PCI vs. CABG in severe CAD
; [[SYNTAX]]: New summary #78: PCI vs. CABG in severe CAD


; [[Early Palliative Care]]: New summary #78: Palliative care in NSCLC
; [[Early Palliative Care]]: New summary #77: Palliative care in NSCLC


; [[JUPITER]]: New summary #77: Rosuvastatin for primary CV prevention
; [[JUPITER]]: New summary #76: Rosuvastatin for primary CV prevention


; [[SPARCL]]: New summary #76: Atorvastatin after stroke
; [[SPARCL]]: New summary #75: Atorvastatin after stroke


==May 2012==
==May 2012==
; [[CHOIR]]: New summary #75: EPO in CKD with anemia
; [[CHOIR]]: New summary #74: EPO in CKD with anemia


; [[SADHART]]: New summary #74: Sertraline for depression post-ACS
; [[SADHART]]: New summary #73: Sertraline for depression post-ACS


==April 2012==
==April 2012==
; [[SHOCK]]: New summary #73: Early PCI/CABG in MI + shock
; [[SHOCK]]: New summary #72: Early PCI/CABG in MI + shock


; [[SOLVD]]: New summary #72: Enalapril in moderate-severe HFrEF
; [[SOLVD]]: New summary #71: Enalapril in moderate-severe HFrEF


; [[DASH]]: New summary #71: DASH diet in HTN
; [[DASH]]: New summary #70: DASH diet in HTN


; [[SEDCOM]]: New summary #70: Dexmedetomidine vs. midazolam for sedation
; [[SEDCOM]]: New summary #69: Dexmedetomidine vs. midazolam for sedation


; [[ACTIVE A]]: New summary #69: ASA/clopidogrel vs. ASA in AF
; [[ACTIVE A]]: New summary #68: ASA/clopidogrel vs. ASA in AF


; [[COGENT]]: New summary #68: PPI plus clopidogrel in CAD
; [[COGENT]]: New summary #67: PPI plus clopidogrel in CAD


; [[European Dexamethasone Study]]: New summary #67: Dexamethasone in meningitis
; [[European Dexamethasone Study]]: New summary #66: Dexamethasone in meningitis
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