Feed:Recent Updates
Jump to navigation
Jump to search
March 2024
- MSLT-1
- New summary #493: SLNB vs. surveillance in melanoma
February 2024
- VITAL (Omega-3 arm)
- New summary #492: Omega-3 FA for CV and cancer prevention
- ACORN
- New summary #491: Empiric cefepime vs. pip-tazo for infection
January 2024
- Writing grants and on service! Back soon.
December 2023
- BELINDA
- New summary #490: Tisa-cel vs. ASCT in R/R DLBCL
November 2023
- SUSTAIN-6
- New summary #489: GLP-1 in DM if high CVD risk
- SELECT
- New summary #488: GLP-1 if prior CVD, BMI ≥27, no DM
October 2023
- LOVIT
- New summary #487: Vitamin C in sepsis
September 2023
- PROPPR
- New summary #486: Transfusion ratios in hemorrhagic shock
- TOPPS
- New summary #485: Platelet transfusions in blood cancers
- TXA for Epistaxis Associated with Antiplatelet Agents
- New summary #484: TXA vs. packing for antiplatelet agent-related epistaxis
August 2023
- STOP-NIDDM
- New summary #483: Acarbose to prevent diabetes in high-risk patients
July 2023
- MATRIX Antithrombin
- New summary #482: Heparin vs. bivalirudin in PCI
- GISSI-HF
- New summary #481: PUFA in patients with heart failure
June 2023
- Vacation for us! Back in July 2023.
May 2023
- On service and have grants due, updates coming in July.
April 2023
- PROPER
- New summary #480: Validation of PERC score in PE
- VOYAGER-PAD
- New summary #479: Rivaroxaban 2.5mg BID in PAD
- CAPE COD
- New summary #478: Hydrocortisone in severe CAP
March 2023
- LIFE
- New summary #477: ARB vs. B-blocker in HTN with LVH
- MOST
- New summary #476: Dual- vs. single-chamber pacing in bradycardia
- CHARM-Alternative
- New summary #475: ARBs in HFrEF
February 2023
- Swedish Two-County Trial
- New summary #474: Mammogram screening 29y follow-up
- ACT I
- New summary #473: Carotid stenting vs. endarterectomy
January 2023
- PROGRESS
- New summary #472: Perindopril±indapamide after stroke
- HEAT-PPCI
- New summary #471: Heparin vs. bivalirudin in PCI
- CIBIS-II
- New summary #470: Bisoprolol in HFrEF
December 2022
- Veterans Affairs Status Epilepticus Cooperative Study Group
- New summary #469: Antiepileptics in status epilepticus
- VITAL (Vitamin D arm)
- New summary #468: Vitamin D for cancer or CVD prevention
November 2022
- AID-ICU
- New summary #467: Haloperidol for ICU delirium
October 2022
- DELIVER
- New summary #466: Dapagliflozin in HFmrEF or HFpEF
- NordICC
- New summary #465: Invitations for screening colonoscopy
September 2022
- ADVOR
- New summary #464: Acetazolamide vs. placebo in acute HF
August 2022
- TICORA
- New summary #463: Intensive vs. standard treatment in early RA
July 2022
- NAVIGATE ESUS
- New summary #462: Rivaroxaban vs. ASA for ESUS (stroke)
- NACSTOP
- New summary #461: 12 vs. 20 hours of NAC in APAP overdose
June 2022
- CRB-401
- New summary #460: Ide-cel CART in myeloma
May 2022
- ESCAPe
- New summary #459: Methylprednisolone vs. Placebo
- Paternity leave
- Back in June!
April 2022
- MERINO
- New summary #458: Piperacillin-tazobactam for ESBL bacteremia
March 2022
- WARSS
- New summary #457: Aspirin vs. warfarin in ischemic stroke
- RITUXVAS
- New summary #456: Rituximab in ANCA-Renal Vasculitis
February 2022
- Still changing servers
- Hi all! We are still in the process of moving our servers to a new platform. Back next month.
January 2022
- Changing servers
- Hi all! Our cloud hosting support service is closing down in the coming months, so we need to take some time and work on moving our project to new servers.
December 2021
- Holiday break
- Hi all! We took an editorial holiday for December. We'll be back in January 2022.
November 2021
- STEP
- New summary #455: Intensive BP control hypertension
- ASPEN
- New summary #454: Zanubrutinib vs. ibrutinib in WM
October 2021
- EARLY-AF
- New summary #453: Cryoablation vs. antiarrhythmics in AF
- MASTER DAPT
- New summary #452: Abbreviated DAPT in high-risk bleeding
- EARLY AF
- New summary #451: Cryoablation vs. antiarrhythmics in AF
September 2021
- ANTLER
- New summary #450: Maintenance vs. discontinuation of antidepressants
- DELIRIA-J
- New summary #449: Ramelteon vs. placebo to prevent delirium
- EMPEROR-Preserved
- New summary #448: Empagliflozin in HFmrEF and HFpEF
August 2021
- HORIZON-PFT
- New summary #447: Zoledronate vs. placebo in osteoporosis
- 65 Trial
- New summary #446: MAP 60-65 vs. usual care in vasodilatory hypotension in ICU
July 2021
- TTM2
- New summary #445: 33°C vs. normothermia after cardiac arrest
- REALITY
- New summary #444: Transfusion thresholds in MI
- PREVAIL
- New summary #443: LAA closure vs. warfarin in AF
June 2021
- MRFIT
- New summary #442: CHD risk modification for CHD mortality prevention
May 2021
- PERC
- New summary #441: PE rule-out criteria
- Novel START
- New summary #440: ICS+LABA PRN in mild asthma
April 2021
- PAUSE
- New summary #439: Perioperative DOAC holding protocols in AF
- STEP 1
- New summary #438: Semaglutide in obesity without diabetes
March 2021
- How Long
- New summary #437: Duration of empiric antibiotics in ↑risk neutropenic fever
- APROCCHSS
- New summary #436: Steroids in septic shock
February 2021
- LoDoCo2
- New summary #435: Colchicine in stable CAD
- PATHWAY-2
- New summary #434: Spironolactone for resistant HTN
January 2021
- EAST-AFNET 4
- New summary #433: Early rhythm vs. rate control in AF
- ISCHEMIA
- New summary #432: PCI/CABG vs. medical therapy in stable CAD
- PRAETORIAN
- New summary #431: Transvenous vs. subq ICD to prevent sudden cardiac death
December 2020
- SUSTAIN
- New summary #430: Crizanlizumab vs. placebo in SCD
- MIST2
- New summary #429: tPA and/or DNase for pleural infection
- HOPE (Sickle Cell Disease)
- New summary #428: Voxelotor in sickle cell disease
November 2020
- ALLHAT-LLT Elderly
- New summary #427: Pravastatin vs usual care for ASCVD primary prevention
October 2020
- CARAVAGGIO
- New summary #426: Apixaban vs. dalteparin in cancer VTE
- DAPA-CKD
- New summary #425: Dapagliflozin in CKD±T2DM
September 2020
- VITAMINS
- New summary #424: Vitamin C, hydrocortisone, & thiamine in septic shock
August 2020
- RECOVERY (Covid-19)
- New summary #423: Dexamethasone vs. usual care in Covid-19
- B-CONVINCED
- New summary #422: Beta-blocker withdrawal in ADHF
July 2020
- On paternity leave! Back in a couple of weeks.
- PARAGON-HF
- New summary #421: ARNI in symptomatic HFpEF
June 2020
- AMAZES
- New summary #420: Azithromycin in chronic asthma
- ACTT-1
- New summary #419: Remdesivir vs. placebo in Covid-19
May 2020
- SPICE III
- New summary #418: Dexmedetomidine in ICU sedation
March & April 2020
- WJC editorial update
- We had to step back from the project for a couple of months during the COVID19 pandemic because of increased clinical responsibilities and lack of childcare. We'll be back in May with your regularly scheduled updates. STAY SAFE everyone!
February 2020
- Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia
- New summary #417: Ibrutinib-rituximab vs. FCR in untreated CLL
- HPS Statin
- New summary #416: Simvastatin in high risk for CVD
January 2020
- STOP-IT
- New summary #415: Duration of abx in intraabdominal infection
- DAWN
- New summary #414: Thrombectomy 6-24 hours after stroke
December 2019
- On paternity leave!
- Back in January 2020.
- DAPA-HF
- New summary #413: Dapagliflozin in HFrEF
November 2019
- COLCOT
- New summary #412: Colchicine vs. placebo in ACS
- CORAL
- New summary #411: Stenting vs. medical therapy in RAS
October 2019
- PARTNER 3
- New summary #410: TAVR for AS in low-risk surgical candidates
- AUGUSTUS
- New summary #409: DOAC, VKA, antiplatelets after PCI with stent and AF
- ISAR-REACT 5
- New summary #408: Ticagrelor vs. prasugrel in ACS
September 2019
- HOPE-3
- New summary #407: Statin, BP meds, both, or neither for CVD 1° prevention
- EASE
- New summary #406: Early surgery in endocarditis
- S-HYDRACYST
- New summary #405: Water intake to prevent UTI
- 3C
- New summary #404: Antibiotic strategies in lower respiratory tract infections
August 2019
- RAMPART
- New summary #403: Midazolam vs. lorazepam for status epilepticus
- AASK
- New summary #402: BP management for CKD in African Americans
July 2019
- CREDENCE
- New summary #401: Canagliflozin in diabetic nephropathy
- ARREST
- New summary #400: Rifampin in S. aureus bacteremia
- DODS
- New summary #399: D-dimer based anticoagulation discontinuation
June 2019
- WASID
- New summary #398: Warfarin vs. aspirin for intracranial atherosclerosis
- SPACE
- New summary #397: Opioids vs. non-opioids in chronic MSK pain
- TRED-HF
- New summary #396: Withdrawal of medications in dilated cardiomyopathy
- TIPPS
- New summary #395: Dalteparin in pregnant woman with thrombophilias
- ROSE
- New summary #394: Cisatracurium NM blockade in ARDS
May 2019
- IALT
- New summary #393: Adjuvant cisplatin in resected NSCLC
- ASPREE
- New summary #392: Aspirin for ASCVD 1° prevention if age >70
- DONATE-HCV
- New summary #391: Donor HCV positive heart and lung transplant
April 2019
- REMATCH
- New summary #390: Destination LVAD in end-stage heart failure
- OVIVA
- New summary #389: PO vs. IV antibiotics for bone/joint infection
- POET
- New summary #388: PO abx after 10d IV abx for left-sided endocarditis
- CABANA
- New summary #387: Catheter ablation vs. anti-arrhythmic therapy in AF
March 2019
- CASSINI
- New summary #386: Rivaroxaban for VTE prevention in cancer
- CAPRICORN
- New summary #385: Carvedilol post-MI with HFrEF
- IDEAL-ICU
- New summary #384: Early vs. delayed RRT in septic shock
- FAIR-HF
- New summary #383: Parenteral iron in HFrEF with iron deficiency
February 2019
- BICAR-ICU
- New summary #382: Bicarbonate in severe metabolic acidosis
- ProMISe
- New summary #381: Multicenter EGDT trial in severe sepsis
- ANNEXA-4
- New summary #380: Andexanet alfa for factor Xa inhibitor reversal
- ART
- New summary #379: Bilateral vs. single IMA graft in multivessel CAD
January 2019
- PIONEER-HF
- New summary #378: ARNI started in ADHF hospitalization
- AVERT
- New summary #377: Apixaban for VTE prevention in cancer
December 2018
- REDUCE-IT
- New summary #376: Icosapent ethyl in CAD
- SELECT-D
- New summary #375: Rivaroxaban vs. LMWH in cancer VTE
- AURORA
- New summary #374: Rosuvastatin in ESRD
- COAPT
- New summary #373: Mitra Clip for HF-related MR
- AF-CHF
- New summary #372: Rhythm control for AF in HFrEF
November 2018
- MIND-USA
- New summary #371: Antipsychotics in ICU delirium
- CIRT
- New summary #370: Low-dose MTX for secondary prevention of CAD
- DIVA
- New summary #369: BMS vs. DES for saphenous vein graft PCI
- APEX
- New summary #368: Betrixaban for extended VTE prophylaxis
- SUP-ICU
- New summary #367: Routine PPI use in the ICU
October 2018
- VEST
- New summary #366: Wearable cardioverter-defibrillator post-MI
- Radiograph vs. MRI for low back pain
- New summary #365: Radiograph vs. MRI for low back pain
- LenDex in High-Risk Smoldering Myeloma
- New summary #364: Lenalidomide/dexamethasone in smoldering MM
- TRAPS
- New summary #363: Rivaroxaban in high-risk APLS
September 2018
- MARINER
- New summary #362: Rivaroxaban VTE ppx after medical admission
- EMBRACE
- New summary #361: Extended EKG monitoring after cryptogenic stroke
- ATTR-ACT
- New summary #360: Tafamidis vs. placebo in amyloid cardiomyopathy
- ASCEND (Aspirin)
- New summary #359: Aspirin for vascular disease prevention in DM
- ACOSOG Z0011
- New summary #358: ALND in SLND-positive breast cancer
August 2018
- SOME
- New summary #357: Occult cancer screening in unprovoked VTE
- Early TIPS
- New summary #356: Early TIPS in high-risk cirrhotic variceal bleeding
- Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock
- New summary #355: Hydrocortisone, Vit C, and thiamine in sepsis
- POINT
- New summary #354: Aspirin/clopidogrel vs. aspirin in stroke/TIA
July 2018
- APPAC
- New summary #353: Antibiotics vs. surgery for acute appendicitis
- RESCUEicp
- New summary #352: Craniectomy vs. medical care for intracranial hypertension
- ATTRACT
- New summary #351: Pharmacomechanical therapy vs. anticoagulation in DVT
- Welcome new medical students, interns, residents, and fellows!
- Buckle in for a year to remember. We hope Journal Club makes it a touch easier. You got this!
June 2018
- MOMENTUM 3
- New summary #350: Centrifugal-flow LVAD vs. axial-flow LVAD in advanced HF
- SPYRAL HTN-ON MED
- New summary #349: Renal denervation in resistant hypertension
- RABBIT 2
- New summary #348: Basal-bolus insulin in inpatients with DM
- PREDIMED
- We incorporated our thoughts on the retraction and replacement of this high-impact NEJM trial on the Mediterranean diet for prevention of CVD.
May 2018
- TIMACS
- New summary #347: Early vs. delayed PCI in NSTEMI and UA
- DPP
- New summary #346: Metformin and intensive lifestyle in prediabetes
- DANAMI-3 PRIMULTI
- New summary #345: Culprit lesion PCI vs. FFR in multivessel CAD
April 2018
- OASIS-5
- New summary #344: Fondaparinux vs. enoxaparin in NSTE-ACS
- TRICS III
- New summary #343: Transfusion thresholds for cardiac surgery
- SMART-MED and SMART-SURG
- New summary #342: NS vs. balanced crystalloids in ICU
- SALT-ED
- New summary #341: Balanced crystalloids vs. NS in non-critical ED patients
- Blood Pressure Reduction in Black Barbershops
- New summary #340: PharmD-guided BP reduction for black men in barbershops
March 2018
- INPULSIS Trials
- New summary #339: Nintedanib in IPF
- EPCAT II
- New summary #338: Aspirin vs. rivaroxaban for postoperative VTE prophylaxis
- HEMO
- New summary #337: High dialysis dose and high-flux membrane in hemodialysis
- Compare-Acute
- New summary #336: Multivessel PCI vs. FFR-guided complete revascularization
- CAP-START
- New summary #335: Antibiotic strategies for PNA
February 2018
- Hokusai-VTE
- New summary #334: Edoxaban vs. LMWH in cancer VTE
- EUROPA
- New summary #333: Perindopril in patients with stable CAD
- CASTLE-AF
- New summary #332: Catheter ablation vs. standard therapy in AF+HF
- ADRENAL
- New summary #331: Hydrocortisone in septic shock
- Hokusai VTE Cancer Trial
- New summary #330: Edoxaban vs. LMWH in cancer VTE
January 2018
- RE-DUAL
- New summary #329: Triple therapy vs. ASA+dabigatran in PCI if AF
- PROTECT AF
- New summary #328: LAA closure vs. warfarin in AF
- ACCORD Lipid
- New summary #327: Fibrate add-on to statins in T2DM
December 2017
- TONE
- New summary #326: Na reduction and weight loss for HTN control in elderly
- ORBITA
- New summary #325: PCI vs. medical therapy in stable angina
- FOCUS
- New summary #324: Transfusion thresholds after hip surgery
November 2017
- CAMERA
- New summary #323: Methotrexate strategies in RA
- ALMS
- New summary #322: MMF vs. CTX in lupus nephritis
- CULPRIT-SHOCK
- New summary #321: Culprit-only vs. multivessel PCI in cardiogenic shock
- V-HeFT II
- New summary #320: Enalapril vs. ISDN/hydralazine in HFrEF
October 2017
- DETO2X-AMI
- New summary #319: Oxygen for suspected MI
- RELAX
- New summary #318: Sildenafil vs. placebo in HFpEF
- PROLONG
- New summary #317: D-Dimer testing after VTE
- CANTOS
- New summary #316: Canakinumab in patients with previous MI
September 2017
- POP-UP
- New summary #315: PPIs for stress ulcer prophylaxis
- Albumin for SBP
- New summary #314: Albumin for SBP in cirrhosis
- COMPASS
- New summary #313: Rivaroxaban, ASA, or both in stable CAD
- HEAT
- New summary #312: Acetaminophen in febrile ICU patients
- AVOID
- New summary #311: Supplemental oxygen in STEMI
August 2017
- CANVAS
- New summary #310: Canagliflozin for CV outcomes in T2DM
- TRIUMPH
- New summary #309: Eculizumab in PNH
- AKIKI
- New summary #308: Early vs. late RRT in severe AKI in ICU
- ATHOS-3
- New summary #307: Angiotensin II vs. placebo in vasodilatory shock
July 2017
- Welcome new medical students, interns, residents, and fellows!
- This is going to be a tough but great year. We hope Journal Club makes it a touch easier for you.
- IRONOUT-HF
- New summary #306: Oral iron vs. placebo in HFrEF and iron deficiency
- EINSTEIN CHOICE
- New summary #305: Rivaroxaban after VTE treatment
June 2017
- AIDA
- New summary #304: Scaffold vs. stent in PCI
- BLOCK-HF
- New summary #303: RV pacing vs. BiV pacing in HF with AV block
- CHAMPION PHOENIX
- New summary #302: Cangrelor during urgent or elective PCI
May 2017
- IFR-SWEDEHEART
- New summary #301: iFR vs. FFR for PCI
- MODIFY I and II
- New summary #300: Bezlotoxumab for C. diff recurrence prevention
- BEST
- New summary #299: PCI vs. CABG for multivessel disease
April 2017
- Cranberry for prevention of pyuria and bacteriuria
- New summary #298: Cranberry in for prevention of pyuria and bacteriuria
- SURTAVI
- New summary #297: TAVI for AS in intermediate-risk surgical candidates
March 2017
- ANNEXA
- New summary #296: Andexanet for reversing Xa inhibitors
- FOURIER
- New summary #295: Evolocumab for CVD events if atherosclerotic disease
- PRECISION
- New summary #294: Celecoxib, naproxen, or ibuprofen for CV safety in arthritis
February 2017
- ENGAGE AF-TIMI 48
- New summary #293: Edoxaban vs. warfarin in AF
- CvLPRIT
- New summary #292: Culprit lesion-only vs. complete revascularization
January 2017
- FLAME (COPD)
- New summary #291: LABA+LAMA vs. LABA+ICS in COPD
- Updated Surviving Sepsis guidelines
- Daily ICU Sedation Holidays, ATN, ARDSNet, ACURASYS, PROSEVA, OSCILLATE, Leuven Surgical Trial, NICE-SUGAR, PRORATA, TRICC, ALBIOS, SAFE, CRISTAL, VASST, SOAP II, SEPSISPAM, CORTICUS, Annane Trial, ProMISe, ARISE, ProCESS, Rivers Trial
- EUCLID (Ticagrelor)
- New summary #290: Ticagrelor vs. clopidogrel in symptomatic PAD
December 2016
- MUSTT
- New summary #289: ICD and antiarrhythmics in mild HFrEF and NSVT
- EXCEL
- New summary #288: CABG vs. PCI in left main CAD
- PIONEER AF-PCI
- New summary #287: DOAC, VKA, antiplatelets after PCI with stent
- AIRTRIP
- New summary #286: Anakinra in colchicine-resistant pericarditis
November 2016
- PESIT
- New summary #285: Prevalence of PE in syncope
- KEYNOTE-024
- New summary #284: Pembrolizumab vs. chemotherapy in NSCLC
- HYPRESS
- New summary #283: Hydrocortisone in severe sepsis
October 2016
- NORSTENT
- New summary #282: Drug-eluting stent vs. bare-metal stent in CAD
- ISAR-TRIPLE
- New summary #281: Triple therapy for 6w vs. 6m after DES
- SOCRATES
- New summary #280: Ticagrelor vs. aspirin in acute stroke or TIA
September 2016
- Welcome new associate editors!
- Benjamin A. Weinberg, MD from Georgetown/Lombardi Cancer Center and Nirmal Choradia, MD from Georgetown/MedStar Montgomery Medical Center. Are you interested in becoming a WJC editor? Read more about the editorial positions.
- AATAC
- New summary #279: AF ablation vs. amiodarone in HFrEF with LVEF ≤40%
- DANISH
- New summary #278: ICD vs. standard care in NICM and LVEF ≤35%
- LEADER
- New summary #277: Liraglutide and CVD endpoints in T2DM
- RAFT
- New summary #276: CRT+ICD for mild-moderate HFrEF
- PRODIGE 4 ACCORD 11
- New summary #275: FOLFIRINOX in pancreatic cancer
- HEARTMATE II
- New summary #274: Continuous-flow LVAD in heart failure
August 2016
- MPACT
- New summary #273: Gemcitabine/nab-paclitaxel in pancreatic cancer
- SPAF
- New summary #272: Aspirin and warfarin in AF
- DAVID
- New summary #271: Dual-chamber vs. ventricular backup pacing in ICD patients
July 2016
- Welcome, new medical students, interns, residents, and fellows!
- MSH
- New summary #270: Hydroxyurea in sickle-cell disease
- ERSPC
- New summary #269: PSA for prostate cancer screening
- FIRE AND ICE
- New summary #268: Cryoablation vs. RF ablation in pAF
- COLONPREV
- New summary #267: FIT vs. colonoscopy for colon cancer screening
June 2016
- VANISH
- New summary #266: Ablation vs. antiarrhythmic drugs in VT
- OAT
- New summary #265: PCI+OMT vs. OMT 3-28 days after MI
- SPS3 Clopidogrel-ASA
- New summary #264: Clopidogrel+ASA for lacunar strokes
May 2016
- PARTNER 2
- New summary #263: TAVI for AS in intermediate-risk surgical candidates
- PARTNER A
- New summary #262: TAVI for AS in high-risk surgical candidates
- TACTICS-TIMI 18
- New summary #261: Early vs. Delayed PCI for UA-NSTEMI
- SHIFT
- New summary #260: Ivabradine in HFrEF
April 2016
- FREEDOM
- New summary #259: CABG vs. PCI for CAD in T2DM
- DINAMIT
- New summary #258: ICD for ICM shortly after MI
- NEAT-HFpEF
- New summary #257: Nitrates for activity tolerance in HFpEF
- CATIE-AD
- New summary #256: Antipsychotics in dementia with psychosis
March 2016
- SAMMPRIS
- New summary #255: Stenting in intracranial stenosis
- STOPAH
- New summary #254: Prednisolone vs. pentoxifylline in alcoholic hepatitis
- PREPIC
- New summary #253: IVC filters for proximal DVT
February 2016
- CYTO-PV
- New summary #252: Hematocrit thresholds in PV
- Benazepril in Severe CKD
- New summary #251: Benazepril in non-diabetic CKD
- 2016 Chest guidelines updated
- Updates applied to AMPLIFY, EINSTEIN-PE, RE-COVER, and other articles addressing antithrombotic therapy.
January 2016
- RE-VERSE AD
- New summary #250: Idarucizumab for dabigatran reversal
- INSIGHT START
- New summary #249: Early vs. delayed ART in HIV
- IDNT
- New summary #248: ARBs in diabetic nephropathy
- SPS3-BP
- New summary #247: SBP <130 vs. SBP 130-150 after lacunar strokes
December 2015
- PEGASUS-TIMI 54
- New summary #246: Extended ticagrelor+ASA after MI
- Ibrutinib in Waldenstrom macroglobulinemia
- New summary #245: Second-line ibrutinib in WM
- ANRS IPERGAY
- New summary #244: Pre-exposure prophylaxis in high-risk men
- Welcome New Editor!
- Mike Kennah, MD at University of Calgary, joins us as Associate Editor of Hematology.
November 2015
- 3SITES
- New summary #243: Central line complications by insertion site
- ZDoggMD!
- Many thanks to ZDoggMD for having us as extras in his just released video, It Was a Good Call Day. It was an incredibly fun and funny shoot.
- Welcome New Editors!
- Kevin Seitz, MD/MSc candidate at Emory University, joins us as Deputy Editor of Pulmonology/Critical Care Medicine. And Jun Ng, MBBS from the University of Queensland, comes aboard as Associate Editor of Endocrinology.
- SPRINT
- New summary #242: BP targets in high-risk patients
- FRISC-II
- New summary #241: Early invasive strategy in UA/NSTEMI
October 2015
- EMPA-REG OUTCOME
- New summary #240: Empagliflozin for CV outcomes in T2DM
- MASS
- New summary #239: US screening for AAA in men
- Updated apps!
- New Journal Club apps are here for iOS and Android! Now with favorites and slick-looking reference pop-ups. Head to journalclubapp.com and grab it for yourself!
- EVOLVE
- New summary #238: Cinacalcet in ESRD
- ADJUST-PE
- Updated guidelines.
September 2015
- COMET-ICE
- New summary #237: Preop coronary revascularization if stable CAD
- CARP
- New summary #236: Preop coronary revascularization if stable CAD
- ODYSSEY LONG TERM
- New summary #235: PCSK9 inhibitor alirocumab for HLD
- Stopping Statins at the End of Life
- New summary #234: Palliative statin discontinuation
- JGME Editorial
- Read all about Wiki Journal Club, the website that powers the Journal Club app
August 2015
- FLAME (Stroke)
- New summary #233: SSRI after CVA for motor recovery
- ECST
- New summary #232: CEA in symptomatic carotid stenosis
- ACT
- New summary #231: Acetylcysteine with IV contrast
- PARTNER B
- Added 5 year follow-up outcomes
- Welcome to our new deputy and associate editors!
- Nephrology - Michael Ke Wang, MD at McMaster University
- Pulmonology/Critical Care - Timothy W. Chan, MD at the University of Toronto
- Radiology - Alex Marro, MD candidate at the University of Toronto
July 2015
- BRIDGE
- New summary #230: LMWH bridging for surgery in AF
- PREPIC 2
- New summary #229: IVC filters for high-risk PE
- ASCEND
- Added new IPF guidelines
- BRIM-3
- New summary #228: Vemurafenib in BRAF V600+ melanoma
- Welcome to our new associate editors!
- Cardiology - Shaan Khurshid, MD from Massachusetts General Hospital
- Oncology - Dave Gupta, MD MPH from Emory University
- Emergency Medicine - Jonathan Mailman, BSc (Pharm), ACPR, PharmD, RPh from Fraser Health Authority
June 2015
- CHARM-Preserved
- New summary #227: ARBs in HFpEF
- COGENT
- Added systematic review and expanded criticisms
- WOEST
- New summary #226: Clopidogrel ± ASA after PCI if on OAC
- Welcome to our first associate editor!
- Lily Zhou, MD from University of Ottawa is joining the WJC team as Associate Editor of Neurology.
- IMPROVE-IT
- New summary #225: Ezetimibe+simvastatin after ACS
- Welcome to our first deputy editor!
- Arun Manmadhan, MD candidate from NYU School of Medicine is joining the WJC team as Deputy Editor of Cardiology.
- Technical update
- An update to the Android version of the Journal Club mobile app is available, fixing the broken links seen by some users. Grab your free update at journalclubapp.com.
May 2015
- ADJUST-PE
- New summary #224: Age-adjusted D-dimer for PE
- WISDOM
- New summary #223: ICS withdrawal in COPD
- MR RESCUE
- New summary #222: Thrombectomy vs. standard care in stroke
April 2015
- Can-SAD
- New summary #221: Light therapy vs. SSRI for SAD
- Technical Update
- We fixed a problem in the Journal Club app which caused a crash for some of our iOS users. The update is available at journalclubapp.com. Thanks for understanding!
- Society of General Internal Medicine conference in Toronto
- Come say hello and check out our poster (Journal Club mobile app usage in developing and developed countries) on Thursday, April 23 at 11:30AM at poster session #2!
- HYVET
- New summary #220: Elderly HTN treatment
March 2015
- ATN
- New summary #219: RRT intensity in ATN
- ASCEND
- Updated to include detailed discussion of survival endpoints, with attention to progression-free survival and overall survival.
- BASALT
- New summary #218: Symptom-based asthma therapy
- HS troponin-T to rule out MI
- New summary #217: High sensitivity troponin for acute chest pain
- CYCLOPS
- New summary #216: Pulse cyclophosphamide for ANCA vasculitis
February 2015
- ELITE-Symphony
- New summary #215: Immunosuppression after kidney transplant
- ORIGIN n-3 Fatty Acids
- New summary #214: Fish oil for high-risk CVD
- HPS2-THRIVE
- New summary #213: Niacin in atherosclerotic disease
January 2015
- TALC
- New summary #212: Tiotropium vs. others in asthma
- Age Trial
- New summary #211: Mammograms for 40-49 year old women
- STAMPEDE
- New summary #210: Gastric bypass vs. medical therapy for T2DM
- Cytisine for Smoking Cessation
- New summary #209: Cytisine vs. NRT for tobacco abuse
December 2014
- VALENCE
- New summary #208: Sofosbuvir+ribavirin for HCV genotypes 2 or 3
- TRISS
- New summary #207: Transfusion thresholds in sepsis
- Lo-Coco 2013
- New summary #206: ATRA-ATO vs. ATRA-chemotherapy in APL
November 2014
- BeSt
- Updated ACR RA guidelines
- FEAST
- New summary #205: Fluid resuscitation in Sub-Saharan Africa
- DAPT
- New summary #204: Aspirin/clopidogrel duration after PCI
- NA-ACCORD
- New summary #203: Early vs. delayed ART in HIV
- ARISE
- New summary #202: EGDT vs. usual care in sepsis
October 2014
- AMPLIFY, AMPLIFY-EXT
- Updated with apixaban's recent FDA approval for the treatment of VTE.
- ALBIOS, SAFE
- Surviving Sepsis Campaign guidelines have been added. (These guidelines have not yet been updated to reflect the results of the CRISTAL study.)
- CHARISMA
- New summary #201: Aspirin/clopidogrel vs. aspirin for CV prevention
- CATT
- New summary #200: Ranibizumab vs. bevacizumab for macular degeneration
- CHOICE
- New summary #199: Free long-acting reversible contraception in teens
- CheckMate-003
- New summary #198: Nivolumab in solid tumors
September 2014
- COMMIT, CURE, ESSENCE, GISSI-3, GUSTO, ISIS-2, MIRACL, PLATO, PROVE IT-TIMI 22, SAVE, TRITON-TIMI 38, VA Cooperative Study, and VALIANT
- Updated NSTE-ACS guidelines
- GUSTO
- New summary #197: tPA in ACS
- Hungarian Prenatal Vitamin Trial
- New summary #196: Perinatal vitamins to prevent neural tube defects
- PARADIGM-HF
- New summary #195: ARNI vs. enalapril in HFrEF
August 2014
- CHARM-Added
- New summary #194: ARB plus ACE-I in HF
- ACCORD BP
- New summary #193: Intensive BP control in T2DM
- COMMIT
- Update: ACS guidelines
- VASST
- New summary #192: Vasopressin in septic shock
- Taking the boards!
- August additions coming in the second half of the month.
- Update: ABIM certified!!
- POISE and POISE-2 ASA
- Update: Added new perioperative guidelines
July 2014
- ASCEND (IPF)
- New summary #191: Pirfenidone in IPF
- CRISTAL
- New summary #190: Colloids vs. crystalloids in shock
- Prednisolone in Severe Alcoholic Hepatitis and Pentoxifylline in Severe Alcoholic Hepatitis
- Update: Added AASLD/ACG guidelines
- SONIC
- New summary #189: Infliximab ± azathioprine induction in Crohn disease
- LESS
- New summary #188: Epidural steroids in spinal stenosis
- ASCEND
- New summary #187: Pirfenidone in IPF
June 2014
- RED-HF
- New summary #186: Darbepoetin in HFrEF
- ORBIT-AF
- New summary #185: ASA/warfarin vs. warfarin in AF
- SWOG 8949
- New summary #184: Cytoreductive nephrectomy in metastatic RCC
- A-HeFT, CARRESS-HF, COMET, CONSENSUS, COPERNICUS, CORONA, DEFINITE, DIG, DOSE, EMPHASIS-HF, EPHESUS, ESCAPE, EVEREST-Outcomes, MADIT-CRT, MADIT-II, MERIT-HF, RALES, SAVE, SCD-HeFT, SOLVD, STICH, V-HeFT, Val-HeFT
- Updated HF guidelines
- StiL
- New summary #183: BR vs. R-CHOP for indolent lymphomas
May 2014
- PLACIDE
- New summary #182: Probiotics to prevent CDAD
- VA-NEPHRON D
- New summary #181: ACE+ARB in DM nephropathy
- RACE II, AFFIRM, ACTIVE A, ACTIVE W, RE-ALIGN, ROCKET AF, AVERROES, ARISTOTLE, RE-LY
- Updated AF guidelines
- TOPCAT
- New summary #180: Spironolactone for HFpEF
- ONTARGET
- New summary #179: Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM
April 2014
- POISE-2 ASA
- New summary #178: Perioperative ASA
- PEITHO
- New summary #177: tPA for submassive PE
- SEPSISPAM
- New summary #176: MAP 65-70 vs. 80-85 mmHg in sepsis
- MADIT-CRT
- New summary #175: CRT in HFrEF with QRS ≥130 msec and mild symptoms
March 2014
- ALBIOS
- New summary #174: Daily albumin in severe sepsis
- ProCESS
- New summary #173: EGDT in septic shock
- TTM
- New summary #172: 33 vs. 36°C body temperature after cardiac arrest
- Rifaximin and Lactulose for HE
- New summary #171: Rifaximin/lactulose vs. lactulose for acute HE
February 2014
- MOPETT
- New summary #170: Low-dose tPA for submassive PE
- PCPT
- New summary #169: Finasteride for prostate cancer prophylaxis
- MIDA
- New summary #168: Early surgery for MR
January 2014
- NOTT
- New summary #167: Continuous vs. nocturnal oxygen in COPD
- AZT Trial
- New summary #166: Zidovudine in HIV/AIDS
- PARAMOUNT
- New summary #165: Maintenance pemetrexed in lung cancer
- UKPDS 34
- New summary #164: Metformin in T2DM
- ICAP
- New summary #163: Colchicine in the first episode of acute pericarditis
December 2013
- Twice-daily RT for SCLC
- New summary #162: Twice-daily RT in limited SCLC
- PARTNER B
- New summary #161: TAVI for AS in poor surgical candidates
- TNT
- New summary #160: Atorvastatin in stable CAD
November 2013
- ESPRIT
- New summary #159: ASA+dipyridamole in secondary stroke prevention
- PRAMI
- New summary #158: PCI to high-risk non-infarct arteries in STEMI
- SYNTAX
- Update: Added ACCF/AHA guidelines
- AVERROES
- New summary #157: Apixaban vs. ASA in AF
October 2013
- MAGELLAN
- New summary #156: Rivaroxaban vs. LMWH for VTE prophylaxis
- RE-ALIGN
- New summary #155: Dabigatran in mechanical heart valves
- EXTRA
- New summary #154: Omalizumab in severe allergic asthma
- HERA
- Update: Added follow-up data demonstrating similar efficacy but increased cardiotoxicity of 2 years of trastuzumab compared to 1 year.
- ATLAS
- New summary #153: 10y vs. 5y tamoxifen in breast cancer
- GI bleeding in ICU patients
- New summary #152: Risk factors for GI bleeds in ICU patients
September 2013
- REDUCE
- New summary #151: 5d vs. 14d steroids in acute COPD
- ASTRAL
- New summary #150: Revascularization in RAS
- METEOR
- New summary #149: Surgery vs. PT in OA with meniscal tear
- Look AHEAD
- New summary #148: Weight loss and exercise in T2DM
- PLATO
- New summary #147: Ticagrelor vs. clopidogrel in ACS
- OSCILLATE
- New summary #146: High-frequency oscillatory vent in early ARDS
- STAR-D
- New summary #145: Tiered approach for depression
August 2013
- LoDoCo
- New summary #144: Colchicine for stable CAD
- AMPLIFY
- New summary #143: Apixaban vs. warfarin in VTE
- NETT
- New summary #142: Lung volume reduction in COPD
- CSG Captopril Trial
- New summary #141: Captopril in T1DM nephropathy
- 4S
- New summary #140: Simvastatin in stable CAD
- ASPIRE
- New summary #139: Aspirin after VTE treatment
- Daily ICU Sedation Holidays
- New summary #138: Scheduled daily sedation holidays in intubated patients
July 2013
- Duct Tape for Treatment of the Common Wart
- New summary #137: Duct tape vs. cryotherapy for warts
- EINSTEIN-PE
- New summary #136: Rivaroxaban vs. warfarin in PE
- WHI
- New summary #135: Postmenopausal estrogen/progesterone
- CHANCE
- New summary #134: ASA/clopidogrel vs. ASA in TIA/stroke
- CRASH-2
- New summary #133: Tranexamic acid in trauma
- NCDS
- New summary #132: Dialysis prescriptions in ESRD
June 2013
- BARI 2D
- New summary #131: CABG/PCI vs. OMT in diabetes with CAD
- ARISTOTLE
- New summary #130: Apixaban vs. warfarin in AF
- ESCAPE
- New summary #129: PA catheters in acute HF management
- PROSEVA
- New summary #128: Prone ventilation in ARDS
- PREDIMED
- New summary #127: Mediterranean diet in CVD prevention
- EVEREST-Outcomes
- New summary #126: Tolvaptan in acute HF in HFrEF
- ACURASYS
- New summary #125: Cisatracurium in ARDS
- DOSE
- New summary #124: Diuretic dosing in acute HF
- ACCOMPLISH
- New summary #123: Benazepril/amlodipine vs. benazepril/HCTZ in HTN
May 2013
- CARRESS-HF
- New summary #122: Ultrafiltration in decompensated HF
- COMMIT
- New summary #121: Metoprolol in acute MI
- RESPECT
- New summary #120: PFO closure in cryptogenic stroke
- ESSENCE
- New summary #119: LMWH vs. UFH in UA/NSTEMI
- ACTIVE W
- New summary #118: ASA/clopidogrel vs. warfarin in AF
- AMPLIFY-EXT
- New summary #117: Apixaban after VTE treatment
April 2013
- TRITON-TIMI 38
- New summary #116: Prasugrel vs. clopidogrel in ACS
- MATCH
- New summary #115: ASA/clopidogrel vs. clopidogrel in stroke
- ROCKET AF
- New summary #114: Rivaroxaban vs. warfarin in AF
- TRICC
- Update: Added transfusion guidelines
- PROVE IT-TIMI 22
- New summary #113: Pravastatin vs. atorvastatin after ACS
- EMILIA
- New summary #112: T-DM1 in metastatic breast cancer
March 2013
- COMET
- Update: Added criticisms regarding dosage target in metoprolol control arm, as well as choosing metoprolol tartrate rather than standard-of-care metoprolol succinate.
- ATLAS ACS-2, TIMI 51
- New summary #111: Rivaroxaban after ACS
- WARFASA
- New summary #110: Aspirin after VTE treatment
February 2013
- Annane Trial
- New summary #109: Corticosteroids in septic shock
- RAVE
- New summary #108: Rituximab vs. cyclophosphamide in ANCA-associated vasculitis
- IPrEx
- New summary #107: ART in primary HIV prevention
- Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
- New summary #106: Fecal transplant in C. difficile
- NSABP B-32
- New summary #105: Sentinel LN biopsy in breast cancer
- Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
- New summary #104: Transfusion thresholds in UGIB
January 2013
- Rivers Trial
- Updates: More on the disagreement over using transfusion to hematocrit >30% for maintaining ScvO2, when studies like TRICC support a more restrictive transfusion strategy. Also, added the baseline characteristics of study participants.
- Yang-Tobin Study
- New summary #103: RSBI for predicting weaning
- RENAAL
- New summary #102: ARBs in diabetic nephropathy
- CLOSURE I
- New summary #101: PFO closure in cryptogenic stroke
December 2012
- STICH
- New summary #100: CABG in ischemic HFrEF
- CURE
- New summary #99: Clopidogrel in UA/NSTEMI
- CAST I
- New summary #98: Antiarrhythmics post-MI
- V-HeFT
- New summary #97: ISDN/hydralazine in HFrEF
November 2012
- PRoFESS
- New summary #96: ASA-dipyridamole vs. clopidogrel in stroke
- IRIS
- New summary #95: Imatinib vs. IFNα/cytarabine in CML
- FAME 2
- New summary #94: FFR-guided PCI vs. OMT in CAD
- Moseley Trial
- New summary #93: Arthroscopy in knee OA
October 2012
- NSABP P-1
- New summary #92: Tamoxifen in breast cancer prevention
- HPTN 052
- New summary #91: Early ART in HIV
- FAME
- New summary #90: FFR-guided PCI in stable CAD
- NLST
- New summary #89: CT vs. CXR in lung cancer screening
- IDEAL
- New summary #88: Early vs. late dialysis in CKD
September 2012
- PROWESS-SHOCK
- New summary #87: Activated protein C in septic shock
- PROWESS
- New summary #86: Activated protein C in severe sepsis
August 2012
- STAR
- New summary #85: Tamoxifen vs. raloxifene in breast cancer prevention
- POISE
- Update: Now reflects a major criticism of the trial, namely the high-doses of long-acting metoprolol used in the immediate preoperative period, which may have led to more strokes and deaths in the metoprolol group
- RE-COVER
- New summary #84: Dabigatran vs. warfarin in VTE
- SMART
- New summary #83: Salmeterol in asthma
- GISSI-3
- Update: Now reflects the 2004 ACC/AHA recommendation for ACE inhibitors or ARBs in all post-STEMI patients
- EMPHASIS-HF
- New summary #82: Eplerenone in HFrEF
- PREVENT TB
- New summary #81: Rifapentine/isoniazid in latent TB
July 2012
- CORONA
- New summary #80: Rosuvastatin in ischemic HFrEF
- CREST
- Update: Now reflects the 2011 ACC/AHA guidelines on carotid artery stenting
- MIRACL
- Update: Now mentions its high loss to follow-up
- RE-LY
- Update: Now reflects the increase in MIs seen with dabigatran
June 2012
- CATIE
- New summary #79: Antipsychotics in schizophrenia
- SYNTAX
- New summary #78: PCI vs. CABG in severe CAD
- Early Palliative Care
- New summary #77: Palliative care in NSCLC
- JUPITER
- New summary #76: Rosuvastatin for primary CV prevention
- SPARCL
- New summary #75: Atorvastatin after stroke
May 2012
- CHOIR
- New summary #74: EPO in CKD with anemia
- SADHART
- New summary #73: Sertraline for depression post-ACS
April 2012
- SHOCK
- New summary #72: Early PCI/CABG in MI + shock
- SOLVD
- New summary #71: Enalapril in moderate-severe HFrEF
- DASH
- New summary #70: DASH diet in HTN
- SEDCOM
- New summary #69: Dexmedetomidine vs. midazolam for sedation
- ACTIVE A
- New summary #68: ASA/clopidogrel vs. ASA in AF
- COGENT
- New summary #67: PPI plus clopidogrel in CAD
- European Dexamethasone Study
- New summary #66: Dexamethasone in meningitis