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April 2017

Cranberry for prevention of pyuria and bacteriuria
New summary #299: Cranberry in NH residents to prevent pyuria and bacteriuria
SURTAVI
New summary #298: TAVI for AS in intermediate-risk surgical candidates

March 2017

ANNEXA
New summary #297: Andexanet for reversing Xa inhibitors
FOURIER
New summary #296: Evolocumab for CVD events if atherosclerotic disease
PRECISION
New summary #295: Celecoxib, naproxen, or ibuprofen for CV safety in arthritis

February 2017

ENGAGE AF-TIMI 48
New summary #294: Edoxaban vs. warfarin in AF
CvLPRIT
New summary #293: Culprit lesion-only vs. complete revascularization

January 2017

FLAME (COPD)
New summary #292: LABA+LAMA vs. LAMA+ICS in COPD
Updated Surviving Sepsis guidelines
Daily ICU Sedation Holidays, ATN, ARDSNet, ACURASYS, PROSEVA, OSCILLATE, Leuven Surgical Trial, NICE-SUGAR, PRORATA, TRICC, ALBIOS, SAFE, CRISTAL, VASST, SOAP II, SEPSISPAM, CORTICUS, Annane Trial, ProMISe, ARISE, ProCESS, Rivers Trial
EUCLID (Ticagrelor)
New summary #291: Ticagrelor vs. clopidogrel in symptomatic PAD

December 2016

MUSTT
New summary #290: ICD vs. antiarrhythmics vs. neither in mild HF and VT at EPS
EXCEL
New summary #289: CABG vs. PCI in left main CAD
PIONEER AF-PCI
New summary #288: DOAC, VKA, antiplatelets after PCI with stent
AIRTRIP
New summary #287: Anakinra in colchicine-resistant pericarditis

November 2016

PESIT
New summary #286: Prevalence of PE in syncope
KEYNOTE-024
New summary #285: Pembrolizumab vs. chemotherapy in NSCLC
HYPRESS
New summary #284: Hydrocortisone vs. placebo in severe sepsis

October 2016

NORSTENT
New summary #283: Drug-eluting stent vs. bare-metal stent in CAD
ISAR-TRIPLE
New summary #282: Triple therapy for 6w vs. 6m after DES
SOCRATES
New summary #281: Ticagrelor vs. aspirin in acute stroke or TIA

September 2016

Welcome new associate editors!
Benjamin A. Weinberg, MD from Georgetown/Lombardi Cancer Center and Nirmal Choradia, MD from Georgetown/MedStar Montgomery Medical Center. Are you interested in becoming a WJC editor? Read more about the editorial positions.
AATAC
New summary #280: AF ablation vs. amiodarone in HFrEF with LVEF <40%
DANISH
New summary #279: ICD vs. standard care in NICM and LVEF ≤35%
LEADER
New summary #278: Liraglutide and CVD endpoints in T2DM
RAFT
New summary #277: New summary #277: CRT+ICD for mild-moderate HFrEF
PRODIGE 4 ACCORD 11
New summary #276: FOLFIRINOX in pancreatic cancer
HEARTMATE II
New summary #275: Continuous-flow LVAD in heart failure

August 2016

MPACT
New summary #274: Gemcitabine/nab-paclitaxel in pancreatic cancer
SPAF
New summary #273: Aspirin and warfarin in AF
DAVID
New summary #272: Dual-chamber vs. ventricular backup pacing in ICD patients

July 2016

Welcome, new medical students, interns, residents, and fellows!
MSH
New summary #271: Hydroxyurea in sickle-cell disease
ERSPC
New summary #270: PSA screening in prostate cancer
FIRE AND ICE
New summary #269: Cryoablation vs. RF ablation in pAF
COLONPREV
New summary #268: FIT vs. colonoscopy for colon cancer screening

June 2016

VANISH
New summary #267: V-tach ablation vs. escalation of antiarrhythmic drugs
OAT
New summary #266: PCI+OMT vs. OMT 3-28 days after MI
SPS3 Clopidogrel-ASA
New summary #265: Clopidogrel+ASA for lacunar strokes

May 2016

PARTNER 2
New summary #264: TAVI for AS in intermediate-risk surgical candidates
PARTNER A
New summary #263: TAVI for AS in high-risk surgical candidates
TACTICS-TIMI 18
New summary #262: Early vs. Delayed PCI for UA-NSTEMI
SHIFT
New summary #261: Ivabradine in HFrEF

April 2016

FREEDOM
New summary #260: CABG vs. PCI for CAD in T2DM
DINAMIT
New summary #259: ICD for ICM shortly after MI
NEAT-HFpEF
New summary #258: Nitrates for activity tolerance in HFpEF
CATIE-AD
New summary #257: Antipsychotics for dementia with psychosis

March 2016

SAMMPRIS
New summary #256: Stenting in intracranial stenosis
STOPAH
New summary #255: Prednisolone vs. pentoxifylline in alcoholic hepatitis
PREPIC
New summary #254: IVC filters for proximal DVT

February 2016

CYTO-PV
New summary #253: Hematocrit thresholds in PV
Benazepril in Severe CKD
New summary #252: Benazepril in nondiabetic CKD
2016 Chest guidelines updated
Updates applied to AMPLIFY, EINSTEIN-PE, RE-COVER, and other articles addressing antithrombotic therapy.

January 2016

RE-VERSE AD
New summary #251: Idarucizumab for dabigatran reversal
INSIGHT START
New summary #250(!!!): Early vs. delayed ART in HIV
IDNT
New summary #249: ARBs in diabetic nephropathy
SPS3-BP
New summary #248: SBP <130 vs. SBP 130-150 after lacunar strokes

December 2015

PEGASUS-TIMI 54
New summary #247: Extended ticagrelor+ASA after MI
Ibrutinib in Waldenstrom macroglobulinemia
New summary #246: Second-line ibrutinib in WM
ANRS IPERGAY
New summary #245: Pre-exposure prophylaxis in high-risk men
Welcome New Editor!
Mike Kennah, MD at University of Calgary, joins us as Associate Editor of Hematology.

November 2015

3SITES
New summary #244: Central line complications by insertion site
ZDoggMD! 
Many thanks to ZDoggMD for having us as extras in his just released video, It Was a Good Call Day. It was an incredibly fun and funny shoot.
Welcome New Editors!
Kevin Seitz, MD/MSc candidate at Emory University, joins us as Deputy Editor of Pulmonology/Critical Care Medicine. And Jun Ng, MBBS from the University of Queensland, comes aboard as Associate Editor of Endocrinology.
SPRINT
New summary #243: SBP <120 vs. <140 mmHg if CVD risk
FRISC-II
New summary #242: Early invasive strategy in UA/NSTEMI

October 2015

EMPA-REG OUTCOME
New summary #242: Empagliflozin for CV outcomes in T2DM
MASS
New summary #241: US screening for AAA in men
Updated apps!
New Journal Club apps are here for iOS and Android! Now with favorites and slick-looking reference pop-ups. Head to journalclubapp.com and grab it for yourself!
EVOLVE
New summary #240: Cinacalcet in ESRD
ADJUST-PE
Updated guidelines.

September 2015

CARP
New summary #239: Preop coronary revascularization if stable CAD
ODYSSEY LONG TERM
New summary #238: PCSK9 inhibitor alirocumab for HLD
Stopping Statins at the End of Life
New summary #237: Palliative statin discontinuation
JGME Editorial
Read all about Wiki Journal Club, the website that powers the Journal Club app

August 2015

FLAME (Stroke)
New summary #236: SSRI after CVA for motor recovery
ECST
New summary #235: CEA in symptomatic carotid stenosis
ACT
New summary #234: Acetylcysteine with IV contrast
PARTNER B
Added 5 year follow-up outcomes
Welcome to our new deputy and associate editors!
Nephrology - Michael Ke Wang, MD at McMaster University
Pulmonology/Critical Care - Timothy W. Chan, MD at the University of Toronto
Radiology - Alex Marro, MD candidate at the University of Toronto

July 2015

BRIDGE
New summary #232: LMWH bridging for surgery in AF
PREPIC 2
New summary #231: IVC filters for high-risk PE
ASCEND
Added new IPF guidelines
BRIM-3
New summary #230: Vemurafenib in BRAF V600+ melanoma
Welcome to our new associate editors!
Cardiology - Shaan Khurshid, MD from Massachusetts General Hospital
Oncology - Dave Gupta, MD MPH from Emory University
Emergency Medicine - Jonathan Mailman, BSc (Pharm), ACPR, PharmD, RPh from Fraser Health Authority

June 2015

CHARM-Preserved
New summary #229: ARB in HFpEF
COGENT
Added systematic review and expanded criticisms
WOEST
New summary #228: Clopidogrel ± ASA after PCI if on OAC
Welcome to our first associate editor!
Lily Zhou, MD from University of Ottawa is joining the WJC team as Associate Editor of Neurology.
IMPROVE-IT
New summary #227: Ezetimibe+simvastatin after ACS
Welcome to our first deputy editor!
Arun Manmadhan, MD candidate from NYU School of Medicine is joining the WJC team as Deputy Editor of Cardiology.
UKPDS 33 and VADT
Added 10 year follow up CV mortality outcomes
Technical update
An update to the Android version of the Journal Club mobile app is available, fixing the broken links seem by some users. Grab your free update at journalclubapp.com.

May 2015

ADJUST-PE
New summary #226: Age-adjusted D-dimer for PE
WISDOM
New summary #225: ICS withdrawal in COPD
MR RESCUE
New summary #224: Thrombectomy vs. standard care in stroke

April 2015

Can-SAD
New summary #223: Light therapy vs. SSRI for SAD
Technical Update
We fixed a problem in the Journal Club app which caused a crash for some of our iOS users. The update is available at journalclubapp.com. Thanks for understanding!
Society of General Internal Medicine conference in Toronto
Come say hello and check out our poster (Journal Club mobile app usage in developing and developed countries) on Thursday, April 23 at 11:30AM at poster session #2!
HYVET
New summary #222: Elderly HTN treatment

March 2015

ATN
New summary #221: RRT intensity in ATN
ASCEND
Updated to include detailed discussion of survival endpoints, with attention to progression-free survival and overall survival.
BASALT
New summary #220: Symptom-based asthma therapy
HS troponin-T to rule out MI
New summary #219: High sensitivity troponin for acute chest pain
CYCLOPS
New summary #218: Pulse cyclophosphamide for ANCA vasculitis
StiL
Updated to mention the ongoing ECOG 2408 study of maintenance rituximab +/- lenalidomide.

February 2015

ELITE-Symphony
New summary #217: Immunosuppression after kidney transplant
ORIGIN n-3 Fatty Acids
New summary #216: Fish oil for high-risk CVD
HPS2-THRIVE
New summary #215: Niacin in atherosclerotic disease

January 2015

TALC
New summary #214: Tiotropium vs. others in asthma
Age Trial
New summary #213: Mammograms for 40-49 year old women
STAMPEDE
New summary #212: Gastric bypass vs. medical therapy for T2DM
Cytisine for Smoking Cessation
New summary #211: Cytisine vs. NRT for tobacco abuse

December 2014

VALENCE
New summary #210: Sofosbuvir+ribavirin for HCV 2&3
TRISS
New summary #209: Transfusion thresholds in sepsis
Lo-Coco 2013
New summary #208: ATRA-ATO vs. ATRA-chemotherapy in APL

November 2014

BeSt
Updated ACR RA guidelines
FEAST
New summary #207: Fluid resuscitation in Sub-Saharan Africa
DAPT
New summary #206: Aspirin/clopidogrel duration after PCI
NA-ACCORD
New summary #205: Early vs. delayed ART in HIV
AZT Trial, HPTN 052, IPrEx
Updated HIV treatment and prevention guidelines
ARISE
New summary #204: EGDT vs. usual care in sepsis

October 2014

AMPLIFY, AMPLIFY-EXT
Updated with apixaban's recent FDA approval for the treatment of VTE.
ALBIOS, SAFE
Surviving Sepsis Campaign guidelines have been added. (These guidelines have not yet been updated to reflect the results of the CRISTAL study.)
CHARISMA
New summary #203: Aspirin/clopidogrel vs. aspirin for CV prevention
CATT
New summary #202: Ranibizumab vs. bevacizumab for macular degeneration
CHOICE
New summary #201: Free long-acting reversible contraception in teens
CheckMate-003
New summary #200: Nivolumab in solid tumors

September 2014

COMMIT, CURE, ESSENCE, GISSI-3, GUSTO, ISIS-2, MIRACL, PLATO, PROVE IT-TIMI 22, SAVE, TRITON-TIMI 38, VA Cooperative Study, and VALIANT
Updated NSTE-ACS guidelines
GUSTO
New summary #199: tPA in ACS
Hungarian Prenatal Vitamin Trial
New summary #198: Perinatal vitamins to prevent neural tube defects
PARADIGM-HF
New summary #197: ARNI vs. ACE-inhibitor in HFrEF

August 2014

CHARM-Added
New summary #196: ARB plus ACE-I in HF
ACCORD BP
New summary #195: Intensive vs. conventional BP control in T2DM
COMMIT
Update: ACS guidelines
VASST
New summary #194: Vasopressin in shock
Taking the boards!
August additions coming in the second half of the month.
Update: ABIM certified!!
POISE and POISE-2 ASA
Update: Added new perioperative guidelines

July 2014

CRISTAL
New summary #193: Colloids vs. crystalloids in shock
Prednisolone in Severe Alcoholic Hepatitis and Pentoxifylline in Severe Alcoholic Hepatitis
Update: Added AASLD/ACG guidelines
SONIC
New summary #192: Infliximab, azathioprine, or both in Crohn's disease
LESS
New summary #191: Epidural steroids in spinal stenosis
ASCEND
New summary #190: Pirfenidone in IPF

June 2014

RED-HF
New summary #189: Darbepoetin in HF
ORBIT-AF
New summary #188: ASA/warfarin vs. warfarin in AF
SWOG 8949
New summary #187: Cytoreductive nephrectomy in metastatic RCC
A-HeFT, CARRESS-HF, COMET, CONSENSUS, COPERNICUS, CORONA, DEFINITE, DIG, DOSE, EMPHASIS-HF, EPHESUS, ESCAPE, EVEREST-Outcomes, MADIT-CRT, MADIT-II, MERIT-HF, RALES, SAVE, SCD-HeFT, SOLVD, STICH, V-HeFT, Val-HeFT
Updated HF guidelines
StiL
New summary #186: B-R vs. R-CHOP for indolent lymphomas

May 2014

PLACIDE
New summary #185: Probiotics to prevent CDAD
VA-NEPHRON D
New summary #184: ACE+ARB in DM nephropathy
RACE II, AFFIRM, ACTIVE A, ACTIVE W, RE-ALIGN, ROCKET AF, AVERROES, ARISTOTLE, RE-LY
Updated AF guidelines
TOPCAT
New summary #183: Spironolactone for HFpEF
ONTARGET
New summary #182: Ramipril vs. telmisartan vs. both in CVD, stroke, PAD, or DM

April 2014

POISE-2 ASA
New summary #181: Perioperative ASA
PEITHO
New summary #180: tPA for submassive PE
SEPSISPAM
New summary #179: MAP 65-70 vs. 80-85 mmHg in sepsis
MADIT-CRT
New summary #178: CRT in HFrEF with QRS ≥130 msec and mild symptoms

March 2014

ALBIOS
New summary #177: Daily albumin in severe sepsis or septic shock
ProCESS
New summary #176: EGDT in septic shock
TTM
New summary #175: 33 vs. 36°C hypothermia after cardiac arrest
Rifaximin and Lactulose for HE
New summary #174: Rifaximin/lactulose vs. lactulose for acute HE

February 2014

MOPETT
New summary #173: Low-dose tPA for submassive PE
PCPT
New summary #172: Finasteride for prostate cancer prophylaxis
MIDA
New summary #171: Early surgery for MR

January 2014

NOTT
New summary #170: Continuous vs. nocturnal oxygen in COPD
AZT Trial
New summary #169: Zidovudine in HIV/AIDS
PARAMOUNT
New summary #168: Maintenance pemetrexed in lung cancer
UKPDS 34
New summary #167: Metformin in T2DM
ICAP
New summary #166: Colchicine in the first episode of acute pericarditis

December 2013

Twice-daily RT for SCLC
New summary #165: Twice-daily RT in limited SCLC
PARTNER B
New summary #164: TAVI for AS in poor surgical candidates
TNT
New summary #163: Atorvastatin in stable CAD

November 2013

ESPRIT
New summary #162: ASA+dipyridamole in secondary stroke prevention
PRAMI
New summary #161: PCI to high-risk non-infarct arteries in STEMI
SYNTAX
Update: Added ACCF/AHA guidelines
AVERROES
New summary #160: Apixaban vs. ASA in AF

October 2013

MAGELLAN
New summary #159: Rivaroxaban vs. LMWH for VTE prophylaxis
RE-ALIGN
New summary #158: Dabigatran in mechanical heart valves
EXTRA
New summary #157: Omalizumab in severe allergic asthma
HERA
Update: Added follow-up data demonstrating similar efficacy but increased cardiotoxicity of 2 years of trastuzumab compared to 1 year.
ATLAS
New summary #156: 10y vs. 5y tamoxifen in breast cancer
GI bleeding in ICU patients
New summary #155: Risk factors for GI bleeds in ICU patients

September 2013

REDUCE
New summary #154: 5d vs. 14d steroids in acute COPD
ASTRAL
New summary #153: Revascularization in RAS
METEOR
New summary #152: Surgery vs. PT in OA with meniscal tear
Look AHEAD
New summary #151: Weight loss and exercise in T2DM
PLATO
New summary #150: Ticagrelor vs. clopidogrel in ACS
OSCILLATE
New summary #149: High-frequency oscillatory vent in early ARDS
STAR-D
New summary #148: Tiered approach for depression

August 2013

LoDoCo
New summary #147: Colchicine for stable CAD
AMPLIFY
New summary #146: Apixaban vs. warfarin in VTE
NETT
New summary #145: Lung volume reduction in COPD
CSG Captopril Trial
New summary #144: Captopril in T1DM nephropathy
4S
New summary #143: Simvastatin in stable CAD
ASPIRE
New summary #142: Aspirin after VTE treatment
Daily ICU Sedation Holidays
New summary #141: Scheduled daily sedation holidays in intubated patients

July 2013

Duct Tape for Treatment of the Common Wart
New summary #140: Duct tape vs. cryotherapy for warts
EINSTEIN-PE
New summary #139: Rivaroxaban vs. warfarin in PE
WHI
New summary #138: Postmenopausal estrogen/progesterone
CHANCE
New summary #137: ASA/clopidogrel vs. ASA in TIA/stroke
CRASH-2
New summary #136: Tranexamic acid in trauma
NCDS
New summary #135: Dialysis prescriptions in ESRD

June 2013

BARI 2D
New summary #134: CABG/PCI vs. OMT in diabetes with CAD
ARISTOTLE
New summary #133: Apixaban vs. warfarin in AF
ESCAPE
New summary #132: PA catheters in acute HF management
PROSEVA
New summary #131: Prone ventilation in ARDS
PREDIMED
New summary #130: Mediterranean diet in CVD prevention
EVEREST-Outcomes
New summary #129: Tolvaptan in HF
ACURASYS
New summary #128: Cisatracurium in ARDS
DOSE
New summary #127: Diuretic dosing in acute HF
ACCOMPLISH
New summary #126: Benazepril/amlodipine vs. benazepril/HCTZ in HTN

May 2013

CARRESS-HF
New summary #125: Ultrafiltration in decompensated HF
COMMIT
New summary #124: Metoprolol in acute MI
RESPECT
New summary #123: PFO closure in cryptogenic stroke
ESSENCE
New summary #122: LMWH vs. UFH in UA/NSTEMI
ACTIVE W
New summary #121: ASA/clopidogrel vs. warfarin in AF
AMPLIFY-EXT‎
New summary #120: Apixaban after VTE treatment

April 2013

TRITON-TIMI 38
New summary #119: Prasugrel vs. clopidogrel in ACS
MATCH
New summary #118: ASA/clopidogrel vs. clopidogrel in stroke
ROCKET AF
New summary #117: Rivaroxaban vs. warfarin in AF
TRICC
Update: Added transfusion guidelines
PROVE IT-TIMI 22
New summary #116: Pravastatin vs. atorvastatin after ACS
EMILIA
New summary #115: T-DM1 in metastatic breast cancer

March 2013

COMET
Update: Added criticisms regarding dosage target in metoprolol control arm, as well as choosing metoprolol tartrate rather than standard-of-care metoprolol succinate.
ATLAS ACS-2, TIMI 51‎
New summary #114:
WARFASA
New summary #112: Aspirin after VTE treatment

February 2013

Annane Trial
New summary #111: Corticosteroids in septic shock
RAVE
New summary #110: Rituximab vs. cyclophosphamide in ANCA-associated vasculitis
IPrEx
New summary #109: ART in primary HIV prevention
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
New summary #108:
NSABP B-32
New summary #106: Sentinel LN biopsy in breast cancer
Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
New summary #105:

January 2013

Rivers Trial
Updates: More on the disagreement over using transfusion to hematocrit >30% for maintaining ScvO2, when studies like TRICC support a more restrictive transfusion strategy. Also, added the baseline characteristics of study participants.
Yang-Tobin Study
New summary #103: RSBI for predicting weaning
RENAAL
New summary #102: ARBs in diabetic nephropathy
CLOSURE I
New summary #101: PFO closure in cryptogenic stroke

December 2012

STICH
New summary #100: CABG in ischemic HF
CURE
New summary #99: Clopidogrel in UA/NSTEMI
CAST I
New summary #98: Antiarrhythmics post-MI
V-HeFT
New summary #97: ISDN/hydralazine in HF

November 2012

PRoFESS
New summary #96: ASA-dipyridamole vs. clopidogrel in stroke
IRIS
New summary #95: Imatinib vs. IFNα/cytarabine in CML
FAME 2
New summary #94: FFR-guided PCI vs. OMT in CAD
Moseley Trial
New summary #93: Arthroscopy in knee OA

October 2012

NSABP P-1
New summary #92: Tamoxifen in breast cancer prevention
HPTN 052
New summary #91: Early ART in HIV
FAME
New summary #90: FFR-guided PCI in stable CAD
NLST
New summary #89: CT vs. CXR in lung cancer screening
IDEAL
New summary #88: Early vs. late dialysis in CKD

September 2012

PROWESS and PROWESS-SHOCK
New summaries #86 and #87: Activated protein C in septic shock

August 2012

STAR
New summary #85: Tamoxifen vs. raloxifene in breast cancer prevention
POISE
Update: Now reflects a major criticism of the trial, namely the high-doses of long-acting metoprolol used in the immediate preoperative period, which may have led to more strokes and deaths in the metoprolol group
RE-COVER
New summary #84: Dabigatran vs. warfarin in VTE
SMART
New summary #83: Salmeterol in asthma
GISSI-3
Update: Now reflects the 2004 ACC/AHA recommendation for ACE inhibitors or ARBs in all post-STEMI patients
EMPHASIS-HF
New summary #82: Eplerenone in HF
PREVENT TB
New summary #81: Rifapentine/isoniazid in latent TB

July 2012

CORONA
New summary #80: Rosuvastatin in ischemic HF
CREST
Update: Now reflects the 2011 ACC/AHA guidelines on carotid artery stenting
MIRACL
Update: Now mentions its high loss to follow-up
RE-LY
Update: Now reflects the increase in MIs seen with dabigatran

June 2012

CATIE
New summary #79: Antipsychotics in schizophrenia
SYNTAX
New summary #78: PCI vs. CABG in severe CAD
Early Palliative Care
New summary #77: Palliative care in NSCLC
JUPITER
New summary #76: Rosuvastatin for primary CV prevention
SPARCL
New summary #75: Atorvastatin after stroke

May 2012

CHOIR
New summary #74: EPO in CKD with anemia
SADHART
New summary #73: Sertraline for depression post-ACS

April 2012

SHOCK
New summary #72: Early PCI/CABG in MI + shock
SOLVD
New summary #71: Enalapril in moderate-severe HF
DASH
New summary #70: DASH diet in HTN
SEDCOM
New summary #69: Dexmedetomidine vs. midazolam for sedation
ACTIVE A
New summary #68: ASA/clopidogrel vs. ASA in AF
COGENT
New summary #67: PPI plus clopidogrel in CAD
European Dexamethasone Study
New summary #66: Dexamethasone in meningitis