User:Tbplante/Articles I Hear about

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April 2015

  • SGIM hospitalist update:
    • CAP-START - Abx for CAP[1] - problems: generalizability because in europe, amox not widely used, 25% of people got abx before admission, long admission
    • Intermittent PPI after high-risk ulcers, systematic review - BID PPI is nonequivalent to drip [2]
    • Early vs. delayed paracentesis [3]
    • SBP and beta blockers for esophageal varices -- harm with beta blocker use if SBP [4]
    • severe alcoholic hepatitis [5][6][7]
    • acute chole, early vs. late - increased BO injury, death [8]
    • bridging increases bleeding, no increased stroke or MI for AF (orbit AF subgroup) [9]
    • intermediate risk of PE, tpa [10]
    • DNR/DNI decision making [11]
    • Apple a day [12]
    • fist bumps and bacterial transmission [13]
  • History of the Welch medical Library [14]

March 2015

  • KDOQI guidelines[15]
  • Increase of BP with age[16]
  • METs on Bruce protocol is highly predictive of mortality[17]

February 2015

  • supplements (eg, folate) for high homocysteine[18]
  • reversal of atheromas with statins in the reversal trial[19]
  • WHI - RCT for low fat diet vs. usual diet in women[20]
  • Metaanalysis for CVD events and n-3 fatty acids[21]
  • No benefit (almost harm) for n-3 fish oil in CVD[22]
  • Open label GISSI-Prevenzione trial for n-3 fish oil supplementation[23]
  • Effects of n-3 fatty acids and CVD risk factors[24]
  • Saturated fat meta-analysis for CHD and stroke[25]
  • Substituting polyunsaturated fats for saturated fats is beneficial[26]
  • Fitness and all-cause mortality (exercise stress test and fitness level, followed forward for mortality)[27]
  • High-intensity statin trials: Prove-it, tnt, ideal, search, A to Z[http://www.ncbi.nlm.nih.gov/pubmed/21067804}
  • Overall statin outcomes through 2005[28]

January 2015

  • Larry Appel's overview of HTN trials:
    • Original: Hamilton 1964, Wolff 1966, VA 1967, HDFP 1979
    • MRC trial of mild hypertension 1985 - placebo vs. bendrofluazide (diuretic) vs. propranolol
    • SHEP 1991 - Isolated systolic HTN in elderly
    • UKPDS 38 - tight control for BP (really hypertensive) better than others
    • HOT - Goal 90 vs. 85 vs. 80 DBP
    • ACCORD BP - Low BP goals vs. normal BP goals in DM, null except reduced stroke
    • AASK - 2x3 factorial design, low BP goal better for proteinuria at 10 years
    • HYVET - age ≥80 randomized to indapamide (diuretic) vs. placebo, lower HF rate
    • TOHP1 - weight loss, Na reduction, stress management, ca, mg, k, fish oil to prevent hypertension
    • TOHP2 - 2x2 weight loss vs Na restriction (no additive effect of both weight loss or Na restriction)
    • OMNIHEART - replace DASH diet with carb/protein/unsaturated fat modifications (all lowered BP), essentially lower carbs (see he Ann Int Med 2005)
    • OMNICARB - Randomized to 5 weeks in each of one of four diets (high/low glycemic index, high/low carbs) - essentially no impact on BP, lipids, insulin resistance
    • TONE - non-pharm interventions in the elderly, sodium reduction/weight loss/ both sodium reduction and weight loss; weight loss sustained; people got off of BP meds
    • Pepperell et al 2001 CPAP on BP for OSA, drop BP
    • EDIC 2003 - tight BS control in T1DM reduces BP
  • Why most research findings are false

December 2014

  • how to handle dropouts in trials [29]
  • nejm Atkins diet, super high drop out rate[30]
  • Probability scores in observational studies[31]
  • Pancreatic cancer and coffee drinking, oversampling of unexposed in controls [32]
  • early clinical evidence, EBM [33]

November 2014

  • Smoking cessation reduces mortality[34]
  • serum biomarkers in HF[35]

October 2014

  • RCTs vs clinical trials[36]
  • RCTs versus historical controls[37]
  • ovarian cancer published trials positive, published and unpublished negative [38]
  • framing of risk and benefit and choice [39]
  • risperdal vs. Haloperidol in schizophrenia[40]

September 2014

  • Placebos don't work [41]
  • Cognitive decline after CABG/delirium[42]
  • Retraction guidelines[43]
  • FGF23 and mortality/ckd [44] [45]
  • ARIC - A1c risk [46]
  • Academy Award Winners live longer [47] - this is an artifact because of immortal time bias [48]
  • Johns Hopkins Precursors Study - young med student's cholesterol predicting subsequent risk of CVD [49]
  • promise HF and milrinone [50]
  • Beta carotine in the physician's health study [51]

August 2014

  • plasma exchange for TTP [52]
  • Osteoporosis and falls [53]
  • Dr. Appel's trials:
    • Dash-sodium [54]
    • OmniHeart [55] (dash modified by carbs, protein, or unsaturated fats)
    • OmniCarb
    • PREMIER [56] (HTN prevalence with advice, EST, or EST+DASH)
    • Weight Loss Maintenance
    • POWER [57] (Weight loss delivery by remote interventions)
    • Diabetes prevention project [58]
    • AASK
      • AASK-CRIC [59] (CKD with APOL1)
    • TOHP [60]
    • TONE [61] (weight loss works)
  • fluid restriction in HF [62]
  • combat trial, dual therapy for bph [63]

July 2014

  • APAP no better than placebo in acute low back pain [64]
  • EVAR trial comparing endovascular aaa repair to conservative management in poor surgical candidates [65]
  • AAA screening study [66]
  • Sutures better than staples after C-section [67]
  • Ezetimibe:
  • Weight loss to prevent DM:
    • Finnish Diabetes Prevention Study [70]
    • US Diabetes Prevention Program (USDPP) [71]
  • Prostate cancer screening trials:
    • European Randomized Study of Screening for Prostate Cancer (ERSPC) [72]
    • Prostate, Lung, Colorectal, and Prostate Cancer Screening Trial (PLCO) [73]

April 2014

  • Other lung cancer screening trials [74] [75]
  • sustained virologic response is good surrogate in hcv [76]
  • Backus trial for screening hcv in birth cohort [77]
  • prayer and blindness [78]
  • ursodiol for pbc [79]
  • first description of early Lyme disease [80]
  • SONIC trial for infliximab in crohns [81]
  • cyclophosphomide in scleroderma lung disease [82]
  • Capacity trials for pirfenidone in IPF [83]
  • albumin reduces mortality with SBP and renal dysfunction [84]
  • HF-Action for cardiac rehab [85]

March 2014

  • Questionable benefit for HD in elderly with CKD V [86]
  • aask trial [87]
  • ezetimbe when you shouldn't [88]
  • evolve, cinacalcet and cvd for HD [89]
  • FHN trial, 3 vs 6 days a week [90]
  • HEMO trial, or how we perform dialysis [91]
  • ANZICS low-dose dopamine for renal protection [92]
  • Metastasectomy in colon cancer [93]
  • FOLFOX [94]
  • FOLFIRI [95]
  • FOLFOX vs. FOLFIRI [96]
  • cannabinoids in pain [97]

February 2014

  • 4D (atorvastatin in ESRD) [98]
  • Myocardial stunning with UF from HD [99]
  • cooperate trial (ace plus arb) retracted [100]
  • va nephron d no benefit for ace plus arb [101]
  • rein trial, ramipril for nephropathy [102] (rein 2 may be better)
  • ANCA vasculitis trials:
  • List of Dr. Johnson's research on skiing/snowboarding, including helmets [107]
  • CVP monitoring blog [108]
  • Shippy CVP 1984 [109]
  • Use of plasmapheresis for ANCA vasculitis [110]
  • Vasopressin plus corticosteroids with mortality benefit in sepsis [111]

January 2014

  • rebound hypercoagulability with dabigatran [112]
  • apixaban for acutely ill [113]
  • home INR monitoring improves control [114]
  • incidentally found calicified coronary arteries on CT scan [115]
  • unethical placebo for azt and pregnancy trials [116]
  • mero for KPC (kleb with carbapenemase) [117]
  • Early vs late trach in micu[118]
  • change of OIs after starting art [119]
  • doxy one dose for Lyme ppx [120]
  • idsa chronic Lyme [121]
  • Finasteride for bph[122] (also see mtops, medical therapy of prostatic symptoms)
  • Soliris/eculizumab for atypical HUS [123]
  • AZT for reduced maternal fetal transmission [124]
  • Amlodipine okay in HF [125] -- also refs 1-4 discuss DHP and worsening outcomes in HF
  • 1977 PCP prophylaxis [126]
  • ASCOT LLA [127]
  • Clinical Practice Guidelines we can Trust [128] guideline modifications, now only take on high quality recs
  • IDEAL [129]
  • ApoB vs nHDL [130]
  • ID consultants reduce mortality with S. Aureus bacteremia [131]
  • Role of ct scan before LP with meningitis symptoms [132]
  • Gent for mrsa endocarditis (not supported) [133]

December 2013

  • Anesthesia awareness [134]
  • vertebroplasty for osteoporotic fractures [135] [136]
  • Occluded Artery Trial[137]
  • SWIPE 2, gent sponges in colorectal surgery [138]
  • HYVET, hypertension tx >80 years [139]
  • US Carvedilol trials [140]
  • Bivalrudin in the ambulance for AMI [141] (from HORIZONS-AMI group)
  • CPAP in OSA for HF [142]
  • VERT, risedronate in post-menopausal women [143]
  • CAN-Sad, SSRI vs. light therapy for SAD [144]
  • CARP Revascularization pre-op [145]

November 2013

October 2013

  • cephalosporin PCN allergy crossreactivity [149]
  • Randomized prayer in CCU [150]

September 2013

  • SPORT trial from Nick [151]
  • ABC awakening and sedation interruption in ICU patients [152]
  • EXPEDITION 1 and 2 - Solanezumab in AD [153]
  • TOPPS - Holding prophylactic platelet transfusions in heme malignancies [154]

August 2013

July 2013

June 2013

May 2013


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