WikiJournalClub:Trial Acronyms

3C

Cough Complication Cohort

4S

Scandinavian Simvastatin Survival Study

A-HeFT

African-American Heart Failure Trial

AAPAC

Appendicitis Acuta

AASK

African American Study of Kidney Disease and Hypertension

AATAC

Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device

ACCOMPLISH

Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension

ACCORD

Action to Control Cardiovascular Risk in Diabetes

ACCORD BP

ACCORD Study Group

ACCORD Lipid

Action to Control Cardiovascular Risk in Diabetes-Lipid

ACORN

Antibiotic Choice on Renal Outcomes

ACOSOG Z0011

The American College of Surgeons Oncology Group (ACOSOG) Z0011

ACT

Acetylcysteine for Contrast-Induced Nephropathy Trial

ACT I

Stent versus endarterectomy for asymptomatic carotid stenosis

ACTIVE A

Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events

ACTIVE W

Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events

ACTT-1

Adaptive Covid-19 Treatment Trial

ACURASYS

ARDS et Curarisation Systematique

ADJUST-PE

Age aDJUSTed D-Dimer to rule out PE

ADRENAL

Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock

ADVANCE

Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation

ADVOR

Acetazolamide in Decompensated Heart Failure With Volume OveRload

AF-CHF

Atrial Fibrillation and Congestive Heart Failure

AFFIRM

Atrial Fibrillation Follow-up Investigation of Rhythm Management

AID-ICU

Agents Intervening against Delirium in the Intensive Care Unit

AIDA

Amsterdam Investigator-Initiated Absorb Strategy All-Comers Trial

AIRTRIP

AnakInRa for Treatment of Recurrent Idiopathic Pericarditis

AKIKI

Artificial Kidney Initiation in Kidney Injury

ALBIOS

Albumin Italian Outcome Sepsis

ALLHAT

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

ALMS

Aspreva Lupus Management Study

AMAZES

Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma

AMBITION

Ambrisentan and Tadalafil in Patients with Pulmonary Arterial Hypertension

AMPLIFY

Apixaban for the Initial Management of Pulmonary Embolism and Deep-Vein Thrombosis as First-Line Therapy

AMPLIFY-EXT

Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy-Extended Treatment

ANNEXA

Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors

ANNEXA-4

Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of Factor Xa Inhibitors

ANTLER

Antidepressants to Prevent Relapse in Depression

APEX

Acutely Medically Ill VTE Prevention with Extended Duration Betrixaban

APROCCHSS

Recombinant Human Activated Protein C and Low Dose of Hydrocortisone and Fludrocortisone in Adult Septic Shock

ARDSNet

Acute Respiratory Distress Syndrome Network

ARISE

Australasian Resuscitation in Sepsis Evaluation

ARISTOTLE

Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation

ARREST

Adjunctive rifampicin for Staphylococcus Aureus Bacteraemia

ART

Arterial Revascularization Trial

ARTESIA

Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation

ASCEND

A Study of Cardiovascular Events in Diabetes

ASCEND

Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis

ASPIRE

Aspirin to Prevent Recurrent Venous Thromboembolism

ASPREE

Aspirin in Reducing Events in the Elderly

ASTRAL

Angioplasty and Stenting for Renal Artery Lesions

ATHOS-3

Angiotensin II for the Treatment of High-Output Shock

ATLAS

Adjuvant Tamoxifen: Longer Against Shorter

ATLAS ACS 2-TIMI 51

Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51

ATN

Acute Renal Failure Trial Network Study

ATTR-ACT

The Transthyretin Amyloidosis Cardiomyopathy Clinical Trial

ATTRACT

Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis

AUGUSTUS

An Open-label, 2 x 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban vs. Vitamin K Antagonist and Aspirin vs. Aspirin Placebo in Patients with Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention

AURORA

A Study to Evaluate the Use of Rosuvastatin in Subjects on Regular Hemodialysis: An Assessment of Survival and Cardiovascular Events

AVERROES

Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment

AVERT

Apixaban for the Prevention of Venous Thromboembolism in High-Risk Ambulatory Cancer Patients

AVOID

Comparing Oxygen with normal air in patients with ST-Segment Elevation Myocardial Infarction who are not hypoxic.

B-CONVINCED

Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode

BARI 2D

Bypass Angioplasty Revascularization Investigation 2 Diabetes

BASALT

Best Adjustment Strategy for Asthma in the Long Term

BEST

The Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation

BICAR-ICU

Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill: A Multiple Center Randomized Clinical Trial

BLOCK-HF

Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block

BPROAD

Blood Pressure Control Target in Diabetes

BRIDGE

Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for Elective Invasive Procedure or Surgery

BRIM-3

BRAF Inhibitor in Melanoma 3

BeSt

Behandel-Strategeieën ("treatment strategies" in Dutch)

Blood-Pressure Reduction in Black Barbershops

Blood-Pressure Reduction in Black Barbershops

CABANA

Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation

CAMERA

Computer Assisted Management in Early Rheumatoid Arthritis

CANTOS

Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

CANVAS

Canagliflozin Cardiovascular Assessment Study

CAP-START

Community-Acquired Pneumonia—Study on the Initial Treatment with Antibiotics of Lower Respiratory Tract Infections

CAPRICORN

Carvedilol Post-Infarct Survival Control in LV Dysfunction

CAPRIE

Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events

CARRESS-HF

Cardiorenal Rescue Study in Acute Decompensated Heart Failure

CASSINI

Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer

CAST I

Cardiac Arrhythmia Suppression Trial

CASTLE-AF

Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation

CATIE

Clinical Antipsychotic Trials of Intervention Effectiveness

CATIE-AD

Clinical Antipsychotic Trials of Intervention Effectiveness–Alzheimer's Disease

CATT

Comparison of Age-Related Macular Degeneration Treatment Trails

CHAMPION PHOENIX

Cangrelor versus standard therapy to achieve optimal management of platelet inhibition

CHANCE

Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events

CHARISMA

Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance

CHARM-Preserved

Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved

CHOICE

CHOICE is not an abbreviation per a communication with the research team

CHOIR

Correction of Hemoglobin and Outcomes in Renal Insufficiency

CIRT

Cardiovascular Inflammation Reduction Trial

CLOSURE I

Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale

CLOT

Comparison of Low Molecular Weight Heparin Versus Oral Anticoagulant Therapy for Long Term Anticoagulation in Cancer Patients With Venous Thromboembolism

COAPT

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation

COGENT

Clopidogrel and the Optimization of Gastrointestinal Events Trial

COLCOT

Colchicine Cardiovascular Outcomes Trial

COMET

Carvedilol Or Metoprolol European Trial

COMMIT/CCS-2

ClOpidogrel and Metoprolol in Myocardial Infarction Trial / Second Chinese Cardiac Study

COMPASS

Cardiovascular Outcomes for People Using Anticoagulation Stratgies

CONSENSUS

Cooperative North Scandinavian Enalapril Survival Study

COPERNICUS

Carvedilol Prospective Randomized Cumulative Survival

CORAL

Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis

CORONA

Controlled Rosuvastatin Multinational Trial in Heart Failure

CORTICUS

Corticosteroid Therapy of Septic Shock

COURAGE

Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation

CRASH-2

Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2

CREDENCE

Canagliflozin and Renal Events in Diabetes and Nephropathy Clinical Evaluation

CREST

Carotid Revascularization Endarterectomy vs. Stenting Trial

CRISTAL

Colloids Versus Crystalloids for the Resuscitation of the Critically Ill

CSG Captopril Trial

Collaborative Study Group Captopril Trial

CULPRIT-SHOCK

Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock

CURE

Clopidogrel in Unstable Angina to Prevent Recurrent Events

CYTO-PV

Cytoreductive Therapy in Polycythemia Vera

CvLPRIT

Complete Versus Lesion-Only Primary PCI Trial

DANAMI-3 PRIMULTI

Third Danish Study of Optimal Acute Treatment of Patients with STEMI: Primary PCI in Multivessel Disease

DANISH

Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality

DAPA-CKD

Dapagliflozin in Chronic Kidney Disease

DAPA-HF

Dapagliflozin in Heart Failure

DAPT

Dual Antiplatelet Therapy

DASH

Dietary Approaches to Stop Hypertension

DAVID

Dual-chamber pacing or ventricular backup pacing in ICD patients

DAWN

DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo

DCCT

Diabetes Control and Complications Trial

DEFINITE

Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation

DELIRIA-J

Delirium Intervention Research for Improving Acute phase outcomes in Japan

DELIVER

Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure

DETO2X-AMI

Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction

DIG

Digitalis Investigation Group

DINAMIT

Defibrillator in Acute Myocardial Infarction Trial

DIVA

Rationale and design of the drug-eluting stents vs bare-metal stents in saphenous vein graft angioplasty

DODS

D-dimer Optimal Duration Study

DONATE HCV

Donors of Hepatitis C NAT Positive Thoracic Allografts for Transplantation Evaluation in Non-HCV Recipients

DOSE

Diuretic Optimization Strategies Evaluation

DPP

Diabetes Prevention Program

DanGer Shock

Danish–German Cardiogenic Shock

EARLY-AF

Early Aggressive Invasive Intervention for Atrial Fibrillation

EASE

Early Surgery versus Conventional Treatment in Infective Endocarditis

EAST-AFNET 4

The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial

ECASS III

European Cooperative Acute Stroke Study III

ECST

European Carotid Surgery Trial

EDIC

Epidemiology of Diabetes Interventions and Complications

EDS

European Dexamethasone Study

EINSTEIN CHOICE

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic Venous Thromboembolism

ELITE-Symphony

Efficacy Limiting Toxicity Elimination-Symphony

EMBRACE

30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event

EMILIA

Emtansine vs. Capecitabine+Lapatinib in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer

EMPEROR-Preserved

Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction

EMPHASIS-HF

Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure

ENGAGE AF-TIMI 48

Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48

EPCAT II

Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II

EPHESUS

Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study

EPIC-CAD

Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease

ERSPC

European Randomized Study of Screening for Prostate Cancer

ESCAPE

Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness

ESPRIT

European/Australasian Stroke Prevention in Reversible Ischaemia Trial

ESSENCE

Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group

EUCLID

Examining use of ticagrelor in peripheral artery disease

EUROPA

European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease

EVEREST

Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan

EVOLVE

Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis

EXCEL

XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL)

EXTRA

A Study of Omalizumab/Xolair in Subjects With Moderate to Severe Persistent Asthma

EcLiPSE

Emergency treatment with Levetiracetam or Phenytoin in convulsive Status Epilepticus in children

FACTT

Fluids and Catheters Treatment Trial

FAIR-HF

IV Iron for Symptoms in Patients with HFrEF and Iron Deficiency

FAME

Fractional Flow Reserve versus Angiography for Multivessel Evaluation

FAME 2

FFR vs. Angiographyfor Multivessel Evaluation 2

FEAST

Fluid Expansion as Supportive Therapy

FIDELIO-DKD

Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease

FLAME

Fluoxetine for Motor Recovery after Acute Ischaemic Stroke

FLAME COPD

Effect of Indacaterol Glycopyronium Vs. Fluticasone Salmeterol on COPD Exacerbations

FOCUS

Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair

FOURIER

Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk

FREEDOM

Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease

FRISC-II

FRagmin and Fast Revascularisation during InStability in Coronary artery disease-II

GISSI-3

Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico

GISSI-HF

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione

GUSTO

Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries

HACA

Hypothermia After Cardiac Arrest

HEARTMATE II

Advanced heart failure treated with continuous-flow left ventricular assist device

HEAT

Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit

HEMO

Hemodialysis

HERA

Herceptin Adjuvant Trial

HOPE

Heart Outcomes Prevention Evaluation

HOPE

Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization

HOPE-3

Heart Outcomes Prevention Evaluation-3

HORIZON-PFT

Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial

HPS

Heart Protection Study Statin Arm

HPS2-THRIVE

Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events

HPTN 052

HIV Prevention Trials Network 052 Study

HYVET

Hypertension in the Very Elderly Trial

IABP-SHOCK II

Intraaortic Balloon Pump in Cardiogenic Shock II

IALT

International Adjuvant Lung Cancer Trial

ICAP

Evaluation of additive benefit of colchicine to conventional therapy in acute pericarditis

IDEAL

Initiating Dialysis Early and Late

IDEAL-ICU

Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit

IDNT

Irbesartan Diabetic Nephropathy Trial

IMPROVE-IT

IMProved Reduction of Outcomes: Vytorin Efficacy International Trial

IRIS

International Randomized Study of Interferon and STI571

IRONOUT-HF

Iron Repletion Effects on Oxygen Uptake in Heart Failure

ISAR-REACT 5

Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5 Trial

ISAR-TRIPLE

Triple therapy in Patients who Require Oral Anticoagulation After Drug-Eluting Stent Implantation

ISCHEMIA

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches

ISIS-2

Second International Study of Infarct Survival

IST

International Stroke Trial

JUPITER

Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin

LEADER

Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results

LESS

Lumbar Epidural Steroid Injections for Spinal Stenosis

LIFE

Cardiovvascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

LOVIT

Lessening Organ Dysfunction with Vitamin C

LoDoCo

Low-Dose Colchicine

LoDoCo2

Low Dose Colchicine 2

Look AHEAD

Look Action for HEAlth in Diabetes

MADIT-CRT

Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy

MADIT-II

Multicenter Automatic Defibrillator Implantation Trial II

MAGELLAN

Multicenter, Randomized, Parallel Group Efficacy and Safety Study for the Prevention of Venous Thromboembolism in Hospitalized Acutely Ill Medical Patients Comparing Rivaroxaban with Enoxaparin

MARINER

Medically Ill Patient Assessment of Rivaroxaban versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk

MASS

Multicentre Aneurysm Screening Study

MASTER DAPT

Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation with an Abbreviated versus Standard DAPT Regimen

MATCH

Management of Atherothrombosis with Clopidogrel in High-risk patients

MATRIX Antithrombin

Minimizing Adverse haemmhorragic events by TRansradial access site and systemic Implementation of angioX (MATRIX)

MERIT-HF

Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure

METEOR

Meniscal Tear in Osteoarthritis Research

MIDA

Mitral Regurgitation International Database

MIND-USA

Modifying the Impact of ICU-Associated Neurological Dysfunction–USA

MIRACL

Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering

MIST2

Second MIST trial

MITIGATE

A Multifaceted Intervention to Improve Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings

MOMENTUM 3

Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3

MOPETT

Moderate Pulmonary Embolism Treated with Thrombolysis

MOST

Ventricular pacing or dual-chamber pacing for sinus-node dysfunction

MPACT

Metastatic Pancreatic Adenocarcinoma Clinical Trial

MRFIT

Multiple Risk Factor Intervention Trial

MSH

Multicenter Study of Hydroxyurea in Sickle-Cell Anemia

MSLT-I

Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma

MUSTT

Multicenter Unsustained Tachycardia Trial

NA-ACCORD

North American AIDS Cohort Collaboration on Research and Design

NASCET

North American Symptomatic Carotid Endarterectomy Trial

NAVIGATE ESUS

New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source

of Undetermined Source

NCDS

The National Cooperative Dialysis Study

NEAT-HFpEF

Nitrate’s Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction

NETT

National Emphysema Treatment Trial

NICE-SUGAR

Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation

NINDS

National Institute of Neurological Disorders and Stroke rt-PA Stroke Study

NLST

National Lung Screening Trial

NORSTENT

Drug-Eluting or Bare-Metal Stents for Percutaneous Coronary Intervention in Stable or Unstable Coronary Artery Disease

NOTT

Nocturnal Oxygen Therapy Trial

NSABP B-32

National Surgical Adjuvant Breast and Bowel Project Trial B-32

NSABP P-1

National Surgical Adjuvant Breast and Bowel Project, Prevention-1

NordICC

Nordic-European Initiative on Colorectal Cancer

Novel START

Novel Symbicort Turbuhaler Asthma Reliever Therapy

OASIS-5

Fifth Organization to Assess Strategies in Acute Ischemic Syndromes

OAT

Occluded Artery Trial

ODYSSEY LONG TERM

Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not

Adequately Controlled with Their Lipid Modifying Therapy

ONTARGET

Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial

ORBIT-AF

Outcomes Registry for Better Informed Treatment of Atrial Fibrillation

ORBITA

Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina

ORIGIN n-3 Fatty Acids

Investigators in the outcome Reduction with an Initial Glargine Intervention

OVIVA

Oral versus Intravenous Antibiotics for Bone and Joint Infection

Oscillate

Oscillation for Acute Respiratory Distress Syndrome Treated Early

PALACE

The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge

PANTER

Minimally Invasive Step Up Approach versus Maximal Necrosectomy in Patients with Acute Necrotising Pancreatitis

PARADIGM-HF

Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure

PARAGON-HF

Prospective Comparison of ARNI Global Outcomes in HF with Preserved Ejection Fraction

PARTNER 2

Placement of Aortic Transcatheter Valves, Cohort A

PARTNER 3

Placement of Aortic Transcatheter Valves 3

PARTNER A

Placement of Aortic Transcatheter Valves, Cohort A

PARTNER B

Placement of Aortic Transcatheter Valves, Cohort B

PATHWAY-2

Prevention and Treatment of Hypertension with Algorithm-Based Therapy (PATHWAY)

PAUSE

Perioperative Anticoagulation Use for Surgery Evaluation

PCPT

Prostate Cancer Prevention Trial

PEITHO

Pulmonary Embolism Thrombolysis trial

PERC

Pulmonary Embolism Rule-Out Criteria

PESIT

Pulmonary Embolism in Syncope Italian Trial

PIONEER AF-PCI

Open-Label, Randomized, Controlled, Multicenter Study Exploring Two Treatment Strategies of Rivaroxaban and a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy in Subjects with AF who Undergo Percutaneous Coronary Intervention

PIONEER-HF

comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode

PIOPED II

Prospective Investigation of Pulmonary Embolism Diagnosis II

PLATO

Platelet Inhibition and Patient Outcomes

POET

Partial Oral Treatment of Endocarditis

POINT

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

POISE

PeriOperative ISchemic Evaluation

POISE-2 ASA

Perioperative ischemic evaluation 2 aspirin arm

POP-UP

Pantoprazole or Placebo for Stress Ulcer Prophylaxis

PRAETORIAN

Prospective Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy

PRAMI

Preventative Angioplasty in Acute Myocardial Infarction

PRECISION

Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen

PREDIMED

Prevención con Dieta Mediterránea

PREPIC

Prévention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group

PREPIC 2

Prevention du Risque d'Embolie Pulmonaire par Interruption Cave 2

PREVAIL

Prospective Randomized Evaluation of the Watchman LAA Closure Device In Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy

PRODIGE 4 ACCORD 11

PRODIGE 4 Actions concertées dans les Cancers COloRectaux et Digestifs

PROFESS

Prevention Regimen for Effectively Avoiding Second Strokes

PROGRESS

Protection Against Recurrent Stroke Study

PROPER

Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients

PROPPR

Pragmatic, Randomized Optimal Platelet and Plasma Ratios

PRORATA

Procalcitonin to Reduce Antibiotic Treatments in Acutely ill patients

PROSEVA

Proning Severe ARDS Patients

PROTECT AF

WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation

PROVE IT-TIMI 22

Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22

PROWESS

Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis

PROWESS-SHOCK

Prospective Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis and Septic Shock

ProCESS

Protocolized Care for Early Septic Shock

RABBIT 2

Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes

RACE II

Rate Control Efficacy in Permanent Atrial Fibrillation: a Comparison between Lenient versus Strict Rate Control II

RAFT

Resynchronization–Defibrillation for Ambulatory Heart Failure

RALES

Randomized Aldactone Evaluation Study

RAMPART

Rapid Anticonvulsant Medication Prior to Arrival Trial

RAVE

Rituximab in ANCA-Associated Vasculitis

RE-ALIGN

Randomized, Phase II Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients after Heart Valve Replacement

RE-COVER

Efficacy and Safety of Dabigatran Compared to Warfarin for 6 Month Treatment of Acute Symptomatic Venous Thromboembolism

RE-DUAL PCI

Randomized evaluation of dual antithrombotic therapy with dabigatran versus triple therapy with warfarin in patients with nonvalvular atrial fibrillation undergoing percutaneous coronary intervention

RE-LY

Randomized Evaluation of Long-Term Anticoagulation Therapy

REALITY

Restrictive and Liberal Transfusion Strategies in Patients With Acute Myocardial Infarction trial

RECOVERY

Randomized Evaluation of Covid-19 Therapy

RED-HF

Reduction of Events by Darbepoetin Alfa in Heart Failure

REDUCE

Reduction in the Use of Corticosteroids in Exacerbated COPD

REDUCE-IT

Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial

RELAX

Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction

REMATCH

Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure

RENAAL

Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan

RESCUEicp

Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure

RESPECT

Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment

ROCKET AF

Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation

ROSE

Reevaluation of Systemic Early Neuromuscular Blockade

SADHAT

Sertraline Antidepressant Heart Attack Randomized Trial

SAFE

Saline versus Albumin Fluid Evaluation

SALT-ED

Saline Against Lactated Ringer's or Plasma-Lyte in the Emergency Department

SAVE

Survival and Ventricular Enlargement Trial

SCD-HeFT

Sudden Cardiac Death in Heart Failure Trial

SEDCOM

Safety and Efficacy of Dexmedetomidine Compared with Midazolam

SELECT

Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity

SELECT-D

Anticoagulation Therapy in Selected Cancer Patients at Risk of Recurrence of Venous Thromboembolism

SEPSISPAM

Sepsis and Mean Arterial Pressure

SHIFT

Systolic Heart failure treatment with the If inhibitor ivabradine Trial

SHOCK

SHould we emergently revascularize Occluded Coronaries for Cardiogenic shocK

SMART

Salmeterol Multicenter Asthma Research Trial

SMART

Isotonic Solutions and Major Adverse Renal Events Trial

SOAP II

Sepsis Occurrence in Acutely Ill Patients II

SOCRATES

Ticagrelor versus aspirin in stroke/TIA

SOLVD

Studies of Left Ventricular Dysfunction

SONIC

Study of Biologic and Immunomodulator Naive Patients in Crohn's Disease

SPACE

Strategies for Prescribing Analgesics Comparative Effectiveness

SPAF

Stroke Prevention in Atrial Fibrillation

SPARCL

Stroke Prevention by Aggressive Reduction in Cholesterol Levels

SPICE III

Sedation Practice in Intensive Care Evaluation

SPRINT

Systolic Blood Pressure Intervention Trial

SPS3-BP

Secondary Prevention of Small Subcortical Strokes-Blood Pressure

SPS3-Clopidogrel+ASA

Secondary Prevention of Small Subcortical Strokes clopidogrel+ASA

SPYRAL HTN-ON MED

Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy

STAMPEDE

Surgical Treatment and Medications Potentially Eradicate Diabetes Efficiently

STAR

Study of Tamoxifen and Raloxifene (NSABP P-2)

STAR-D

Sequenced Treatment Alternatives to Relieve Depression

STEP

Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients

STEP 1

Semaglutide Treatment Effect in People with Obesity 1

STICH

Surgical Treatment for Ischemic Heart Failure

STOP-IT

Study to Optimize Peritoneal Infection Therapy

STOP-NIDDM

Study to Prevent NIDDM

STOPAH

Steroids or Pentoxifylline for Alcoholic Hepatitis

SUP-ICU

Stress Ulcer Prophylaxis in the Intensive Care Unit

SURTAVI

Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement

SUSTAIN-6

Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes

SYNTAX

Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery

StiL

Study Group Indolent Lymphomas

TACTICS-TIMI 18

Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban

TALC

Tiotropium Bromide as an Alternative to Increased Inhaled Glucocorticoid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid

TICORA

Tight Control of Rheumatoid Arthritis

TIMACS

The Timing of Intervention in Acute Coronary Syndromes

TIPPS

Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia

TNT

Treating to New Targets

TONE

Trial of Nonpharmacologic Interventions in the Elderly

TOPCAT

Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist

TOPPS

Trial of Prophylactic Platelets

TORCH

Towards a Revolution in COPD Health

TRACE-III

Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-III

TRAPS

Trial on Rivaroxaban in AntiPhospholipid Syndrome

TREAT

Trial to Reduce Cardiovascular Events With Aranesp Therapy

TRED-HF

Treatment for heart failure in patients with recovered dilated cardiomyopathy

TRICC

Transfusion Requirements in Critical Care

TRICS III

Transfusion Requirements in Cardiac Surgery

TRISS

Transfusion Requirements in Septic Shock

TRITON-TIMI 38

Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel–Thrombolysis in Myocardial Infarction 38

TRIUMPH

Transfusion Reduction Efficacy and Safety Clinical Investigation, a Randomized, Multicenter, Double-Blind, Placebo-Controlled, Using Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

TTM

Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest

TTM2

Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest 2

UKPDS

United Kingdom Prospective Diabetes Study

UKPDS 34

UK Prospective Diabetes Study 34

UPLIFT

Understanding Potential Long-Term Impacts on Function with Tiotropium

V-HeFT

Vasodilator Heart Failure Trial

V-HeFT II

Vasodilator Heart Failure Trial II

VA NEPHRON-D

Veterans Affairs Nephropathy in Diabetes

VADT

Veterans Affairs Diabetes Trial

VALIANT

Valsartan in Acute Myocardial Infarction Trial

VANISH

Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs

VASST

Vasopressin and Septic Shock Trial

VEST

Vest Prevention of Early Sudden Death

VITAL

Vitamin D and Omega-3 Trial

VITAL

VITamin D and OmegA-3 TriaL

VITAMINS

The VitamIn C, HydrocorTisone and ThiAMINe in Patients With Septic Shock Trial

Val-HeFT

Valsartan Heart Failure Trial

WARFASA

Warfarin and Aspirin

WARSS

Warfarin–Aspirin Recurrent Stroke Study

WASID

Warfarin-Aspirin Symptomatic Intracranial Disease

WHI E+P

Women's Health Initiative Estrogen and Progestin Trial

WISDOM

Withdrawal of Inhaled Steroids during Optimized Bronchodilator Management

WOEST

What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing

WOSCOPS

West of Scotland Coronary Prevention Study

iFR-SWEDEHEART

Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome

iPrEx

Iniciativa Profilaxis Pre Exposicion ("Preexposure Prophylaxis Initiative")