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         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:34:21Z",
             "timestamp" : "2017-12-03T22:34:03Z",
             "briefDesignDescription" : "PFO closure in cryptogenic stroke",
             "briefDesignDescription" : "Antipsychotics in schizophrenia",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009639",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa051688",
             "pageid" : 1093,
             "pageid" : 419,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009639",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa051688",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Furlan AJ, <i>et al</i>. \"Closure or medical therapy for cryptogenic stroke with patent foramen ovale\". <i>The New England Journal of Medicine</i>. 2012. 366(11):991-999.",
             "citation" : "Lieberman JA, <i>et al</i>. \"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia\". <i>The New England Journal of Medicine</i>. 2005. 353(12):1209-23.",
             "subspecialties" : "Neurology;Cardiology",
             "subspecialties" : "Psychiatry",
             "expansion" : "Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale",
             "expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness",
             "statusUsableDate" : "2013-01-01",
             "statusUsableDate" : "2012-06-01",
             "briefResultsDescription" : "PFO closure does not reduce recurrent stroke",
             "briefResultsDescription" : "Olanzapine ↓discontinuations but ↑metabolic syndrome, and perphenazine ˜ atypicals",
             "published" : "2012-03-15",
             "published" : "2005-09-22",
             "pageName" : "CLOSURE I",
             "pageName" : "CATIE",
             "diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
             "diseases" : "Schizophrenia",
             "abbreviation" : "CLOSURE I",
             "abbreviation" : "CATIE",
             "title" : "Closure or medical therapy for cryptogenic stroke with patent foramen ovale",
             "title" : "Effectiveness of antipsychotic drugs in patients with chronic schizophrenia",
             "pmid" : "22417252"
             "pmid" : "16172203"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:34:50Z",
             "timestamp" : "2017-12-03T22:34:04Z",
             "briefDesignDescription" : "Aspirin/clopidogrel duration after PCI",
             "briefDesignDescription" : "Antipsychotics in dementia with psychosis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409312",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa061240",
             "pageid" : 2264,
             "pageid" : 2724,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409312",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa061240",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Mauri L, <i>et al</i>. \"Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents\". <i>The New England Journal of Medicine</i>. 2014. 371(23):2155-2166.",
             "citation" : "Schneider LS, <i>et al</i>. \"Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease\". <i>The New England Journal of Medicine</i>. 2006. 355(15):1525-38.",
            "subspecialties" : "Psychiatry",
            "expansion" : "Clinical Antipsychotic Trials of Intervention Effectiveness–Alzheimer's Disease",
            "statusUsableDate" : "2016-04-01",
            "briefResultsDescription" : "Antipsychotics no better than placebo",
            "published" : "2006-10-12",
            "pageName" : "CATIE-AD",
            "diseases" : "Dementia;Alzheimer Disease;Psychosis",
            "abbreviation" : "CATIE-AD",
            "title" : "Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease",
            "pmid" : "17035647"
        },
        {
            "timestamp" : "2017-12-03T22:34:05Z",
            "briefDesignDescription" : "Ranibizumab vs. bevacizumab for macular degeneration",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1102673",
            "pageid" : 2250,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102673",
            "trainingLevel" : "Resident",
            "citation" : "The CATT Research Group Writers. \"Ranibizumab and bevacizumab for neovascular age-related macular degeneration\". <i>The New England Journal of Medicine</i>. 2011. 364(20):1897-1908.",
            "subspecialties" : "Ophthalmology",
            "expansion" : "Comparison of Age-Related Macular Degeneration Treatment Trails",
            "statusUsableDate" : "2014-10-01",
            "briefResultsDescription" : "Ranibizumab vs. bevacizumab similar even when comparing monthly vs. PRN scheduling",
            "published" : "2011-05-19",
            "pageName" : "CATT",
            "diseases" : "Macular Degeneration",
            "abbreviation" : "CATT",
            "title" : "Ranibizumab and bevacizumab for neovascular age-related macular degeneration",
            "pmid" : "21526923"
        },
        {
            "timestamp" : "2019-03-07T17:23:15Z",
            "briefDesignDescription" : "Cangrelor during urgent or elective PCI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300815",
            "pageid" : 2935,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300815",
            "trainingLevel" : "Fellow",
            "citation" : "Bhatt DL, <i>et al</i>. \"Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events\". <i>The New England Journal of Medicine</i>. 2013. 368(14):1303-1313.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Dual Antiplatelet Therapy",
             "expansion" : "Cangrelor versus standard therapy to achieve optimal management of platelet inhibition",
             "statusUsableDate" : "2014-11-01",
             "statusUsableDate" : "2017-06-01",
             "briefResultsDescription" : "Longer duration reduces stent thrombosis, MI, stroke, but increases mortality/bleeding",
             "briefResultsDescription" : "Cangrelor reduces rate of ischemic events during PCI",
             "published" : "2014-11-16",
             "published" : "2013-04-04",
             "pageName" : "DAPT",
             "pageName" : "CHAMPION PHOENIX",
             "diseases" : "Coronary Artery Disease;Myocardial Infarction;Stroke",
             "diseases" : "Coronary Artery Disease;Acute Coronary Syndrome;Myocardial Infarction",
             "abbreviation" : "DAPT",
             "abbreviation" : "CHAMPION PHOENIX",
             "title" : "Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents",
             "title" : "Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events",
             "pmid" : "25399658"
             "pmid" : "23473369"
         },
         },
         {
         {
             "timestamp" : "2020-09-22T18:22:21Z",
             "timestamp" : "2020-01-03T00:19:05Z",
             "briefDesignDescription" : "DASH diet in HTN",
             "briefDesignDescription" : "ASA/clopidogrel vs. ASA in TIA/stroke",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199704173361601",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1215340",
             "pageid" : 90,
             "pageid" : 1530,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199704173361601",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1215340",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Appel LJ, <i>et al</i>. \"A clinical trial of the effects of dietary patterns on blood pressure\". <i>The New England Journal of Medicine</i>. 1997. 336(16):1117-1124.",
             "citation" : "Wang Y, <i>et al</i>. \"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack\". <i>The New England Journal of Medicine</i>. 2013. 369(1):11-19.",
             "subspecialties" : "Cardiology;Nephrology",
             "subspecialties" : "Neurology",
             "expansion" : "Dietary Approaches to Stop Hypertension",
             "expansion" : "Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events",
             "statusUsableDate" : "2012-04-01",
             "statusUsableDate" : "2013-07-01",
             "briefResultsDescription" : "DASH diet reduces SBP and DBP",
             "briefResultsDescription" : "ASA/clopidogrel decreases stroke rates compared to ASA alone in TIA and high-risk CVA",
             "published" : "1997-04-17",
             "published" : "2013-07-04",
             "pageName" : "DASH",
             "pageName" : "CHANCE",
             "diseases" : "Hypertension",
             "diseases" : "Stroke;Transient Ischemic Attack",
             "abbreviation" : "DASH",
             "abbreviation" : "CHANCE",
             "title" : "A clinical trial of the effects of dietary patterns on blood pressure",
             "title" : "Clopidogrel with aspirin in acute minor stroke or transient ischemic attack",
             "pmid" : "9099655"
             "pmid" : "23803136"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:34:54Z",
            "timestamp" : "2018-03-08T18:57:50Z",
             "briefDesignDescription" : "Dual-chamber vs. ventricular backup pacing in ICD patients",
            "briefDesignDescription" : "Aspirin/clopidogrel vs. aspirin for CV prevention",
             "fulltexturl" : "http://jama.jamanetwork.com/article.aspx?volume",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa060989",
             "pageid" : 2713,
            "pageid" : 2175,
             "pdfurl" : null,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa060989",
             "trainingLevel" : "Resident",
            "trainingLevel" : "Resident",
             "citation" : "Wilkoff BL, <i>et al</i>. \"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator\". <i>Journal of the American Medical Association</i>. 2002. 288(24):3115-3123.",
            "citation" : "Bhatt DL, <i>et al</i>. \"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events\". <i>The New England Journal of Medicine</i>. 2006. 354(16):1706-1717.",
            "subspecialties" : "Cardiology",
            "expansion" : "Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance",
            "statusUsableDate" : "2014-10-01",
            "briefResultsDescription" : "Combination therapy no better than aspirin alone, more bleeding",
            "published" : "2006-04-20",
            "pageName" : "CHARISMA",
            "diseases" : "Cardiovascular Disease;Stroke;Myocardial Infarction;Acute Coronary Syndrome",
            "abbreviation" : "CHARISMA",
            "title" : "Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events",
            "pmid" : "16531616"
        },
        {
             "timestamp" : "2017-12-03T22:34:11Z",
             "briefDesignDescription" : "ARB plus ACE-I in HF",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2914283-3/fulltext",
             "pageid" : 2126,
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603142833.pdf",
             "trainingLevel" : "Intern",
             "citation" : "McMurray JJ, <i>et al</i>. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial\". <i>The Lancet</i>. 2003. 362(9386):767-771.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Dual-chamber pacing or ventricular backup pacing in ICD patients",
             "expansion" : null,
             "statusUsableDate" : "2016-08-01",
             "statusUsableDate" : "2014-08-01",
             "briefResultsDescription" : "Ventricular backup pacemaker superior to dual-chamber pacemaker",
             "briefResultsDescription" : "Adding ARB to ACE-I reduces CV events and HF hospitalizations",
             "published" : "2002-12-25",
             "published" : "2003-09-06",
             "pageName" : "DAVID",
             "pageName" : "CHARM-Added",
             "diseases" : "Bradycardia",
             "diseases" : "Heart Failure",
             "abbreviation" : "DAVID",
             "abbreviation" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Added",
             "title" : "Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator",
             "title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial",
             "pmid" : "12495391"
             "pmid" : "13678869"
         },
         },
         {
         {
             "timestamp" : "2020-01-25T11:34:00Z",
             "timestamp" : "2023-03-30T17:58:17Z",
             "briefDesignDescription" : "Thrombectomy 6-24 hours after stroke",
            "briefDesignDescription" : "ARBs in HFrEF",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1706442",
            "fulltexturl" : "https://doi.org/10.1016/s0140-6736(03)14284-5",
             "pageid" : 3529,
            "pageid" : 2416,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1706442",
            "pdfurl" : "",
             "trainingLevel" : "Resident",
            "trainingLevel" : "Intern",
             "citation" : "Nogueira RG, <i>et al</i>. \"Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct\". <i>The New England Journal of Medicine</i>. 2018. 378(1):11-21.",
            "citation" : "Granger CB, <i>et al</i>. \"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial\". <i>The Lancet</i>. 2003. 362(9386):772-776.",
             "subspecialties" : "Neurology",
            "subspecialties" : "Cardiology",
             "expansion" : "DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo",
            "expansion" : "",
             "statusUsableDate" : "2020-01-23",
            "statusUsableDate" : "2023-03-29",
             "briefResultsDescription" : "Thrombectomy improved 90-day outcomes compared to standard care",
            "briefResultsDescription" : "ARBs reduce CV mortality and HF hospitalization in HFrEF",
             "published" : "2018-01-04",
            "published" : "2003-09-06",
             "pageName" : "DAWN",
            "pageName" : "CHARM-Alternative",
             "diseases" : "Stroke",
            "diseases" : "Heart Failure",
             "abbreviation" : "DAWN",
            "abbreviation" : "CHARM-Alternative",
             "title" : "Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct",
            "title" : "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial",
             "pmid" : "29129157"
            "pmid" : "13678870"
        },
        {
            "timestamp" : "2017-12-03T22:34:16Z",
            "briefDesignDescription" : "ARBs in HFpEF",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14285-7/fulltext",
            "pageid" : 2381,
            "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14285-7.pdf",
            "trainingLevel" : "Intern",
            "citation" : "Yusuf S, <i>et al</i>. \"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial\". <i>The Lancet</i>. 2003. 362(9386):777-781.",
            "subspecialties" : "Cardiology",
            "expansion" : "Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved",
            "statusUsableDate" : "2015-06-01",
            "briefResultsDescription" : "Candesartan modestly reduces HF admissions but does not affect CV mortality",
            "published" : "2003-09-06",
            "pageName" : "CHARM-Preserved",
            "diseases" : "Heart Failure",
            "abbreviation" : "CHARM-Preserved",
            "title" : "Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial",
            "pmid" : "13678871"
        },
        {
            "timestamp" : "2017-12-03T22:34:42Z",
             "briefDesignDescription" : "Nivolumab in solid tumors",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1200690",
             "pageid" : 2220,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1200690",
             "trainingLevel" : "Resident",
             "citation" : "Topalian SL, <i>et al</i>. \"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer\". <i>The New England Journal of Medicine</i>. 2012. 366(26):2443-54.",
             "subspecialties" : "Oncology",
             "expansion" : "",
             "statusUsableDate" : "2014-10-01",
             "briefResultsDescription" : "Nivolumab was well tolerated, yielded durable remissions in about 30% of patients",
             "published" : "2012-06-28",
             "pageName" : "CheckMate-003",
             "diseases" : "Melanoma;Lung Cancer;Renal Cell Carcinoma",
             "abbreviation" : "",
             "title" : "Safety, activity, and immune correlates of anti-PD-1 antibody in cancer",
             "pmid" : "22658127"
         },
         },
         {
         {
             "timestamp" : "2012-09-16T11:23:12Z",
             "timestamp" : "2017-12-03T22:34:18Z",
             "briefDesignDescription" : "Intensive glycemic therapy in T1DM",
             "briefDesignDescription" : "Free long-acting reversible contraception in teens",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309303291401",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1400506",
             "pageid" : 135,
             "pageid" : 2233,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309303291401",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1400506",
             "trainingLevel" : "Student",
             "trainingLevel" : "Student",
             "citation" : "DCCT Research Group. \"The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus\". <i>The New England Journal of Medicine</i>. 1993. 329(14):977-986.",
             "citation" : "Secura GM, <i>et al</i>. \"Provision of no-cost, long-acting contraception and teenage pregnancy\". <i>The New England Journal of Medicine</i>. 2014. 371(14):1316-1326.",
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Gynecology;Preventive Medicine;Obstetrics",
             "expansion" : "Diabetes Control and Complications Trial",
             "expansion" : "CHOICE is not an abbreviation per a communication with the research team",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2014-10-01",
             "briefResultsDescription" : "Intensive therapy delays microvascular but not macrovascular complications in T1DM",
             "briefResultsDescription" : "LARC reduced pregnancy, live births, and abortions",
             "published" : "1993-09-30",
             "published" : "2014-10-02",
             "pageName" : "DCCT",
             "pageName" : "CHOICE",
             "diseases" : "Diabetes Mellitus",
             "diseases" : "Unplanned Pregnancy",
             "abbreviation" : "DCCT",
             "abbreviation" : "CHOICE",
             "title" : "The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus",
             "title" : "Provision of no-cost, long-acting contraception and teenage pregnancy",
             "pmid" : "8366922"
             "pmid" : "25271604"
         },
         },
         {
         {
             "timestamp" : "2014-06-13T04:45:33Z",
             "timestamp" : "2019-02-21T16:44:19Z",
             "briefDesignDescription" : "ICD vs. medical therapy in HFrEF",
             "briefDesignDescription" : "EPO in CKD with anemia",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa033088",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa065485",
             "pageid" : 84,
             "pageid" : 422,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa033088",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa065485",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Kadish A, <i>et al</i>. \"Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy\". <i>The New England Journal of Medicine</i>. 2004. 350(21):2151-2158.",
             "citation" : "Singh AK, <i>et al</i>. \"Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease\". <i>The New England Journal of Medicine</i>. 2006. 355(20):2085-2098.",
            "subspecialties" : "Nephrology;Hematology",
            "expansion" : "Correction of Hemoglobin and Outcomes in Renal Insufficiency",
            "statusUsableDate" : "2012-05-01",
            "briefResultsDescription" : "Increased morbidity/mortality with higher hgb targets",
            "published" : "2006-11-16",
            "pageName" : "CHOIR",
            "diseases" : "Chronic Kidney Disease;Anemia",
            "abbreviation" : "CHOIR",
            "title" : "Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease",
            "pmid" : "17108343"
        },
        {
            "timestamp" : "2023-02-02T19:39:17Z",
            "briefDesignDescription" : "Bisoprolol in HFrEF",
            "fulltexturl" : "https://linkinghub.elsevier.com/retrieve/pii/S0140673698111819",
            "pageid" : 2436,
            "pdfurl" : "",
            "trainingLevel" : "Student",
            "citation" : "CIBIS-II Writers. \"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial\". <i>The Lancet</i>. 1999. 353(9146):9-13.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation",
             "expansion" : "",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2023-01-30",
             "briefResultsDescription" : "ICD reduced risk of arrhythmogenic sudden death, but not overall mortality",
             "briefResultsDescription" : "Bisoprolol lowers mortality in HFrEF",
             "published" : "2004-05-20",
             "published" : "1999-01-02",
             "pageName" : "DEFINITE",
             "pageName" : "CIBIS-II",
             "diseases" : "Heart Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "DEFINITE",
             "abbreviation" : "CIBIS-II",
             "title" : "Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy",
             "title" : "The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial",
             "pmid" : "15152060"
             "pmid" : "10023943"
         },
         },
         {
         {
             "timestamp" : "2021-10-04T20:25:15Z",
             "timestamp" : "2018-11-30T20:42:52Z",
             "briefDesignDescription" : "Ramelteon vs. placebo to prevent delirium",
             "briefDesignDescription" : "Low-dose MTX for secondary prevention of CAD",
             "fulltexturl" : "http://jamanetwork.com/journals/jamapsychiatry/fullarticle/1831407",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1809798",
             "pageid" : 2806,
             "pageid" : 3739,
             "pdfurl" : "",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1809798",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Hatta K, <i>et al</i>. \"Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial\". <i>JAMA Psychiatry</i>. 2014. 71(4):397-403.",
             "citation" : "Ridker PM, <i>et al</i>. \"Low-dose methotrexate for the prevention of atherosclerotic events\". <i>The New England Journal of Medicine</i>. 2018. epub 2018-11-10:1-11.",
             "subspecialties" : "Psychiatry;Geriatrics",
             "subspecialties" : "Cardiology",
             "expansion" : "Delirium Intervention Research for Improving Acute phase outcomes in Japan",
             "expansion" : "Cardiovascular Inflammation Reduction Trial",
             "statusUsableDate" : "2021-09-30",
             "statusUsableDate" : "2018-11-14",
             "briefResultsDescription" : "Ramelteon decreased risk of delirium in elderly patients",
             "briefResultsDescription" : "Low-dose methotrexate not superior to placebo for secondary prevention of CAD",
             "published" : "2014-04-01",
             "published" : "2018-11-10",
             "pageName" : "DELIRIA-J",
             "pageName" : "CIRT",
             "diseases" : "Delirium",
             "diseases" : "Coronary artery disease",
             "abbreviation" : "DELIRIA-J",
             "abbreviation" : "CIRT",
             "title" : "Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial",
             "title" : "Low-dose methotrexate for the prevention of atherosclerotic events",
             "pmid" : "24554232"
             "pmid" : "30415610"
         },
         },
         {
         {
             "timestamp" : "2023-05-04T03:39:40Z",
             "timestamp" : "2017-12-03T22:34:21Z",
             "briefDesignDescription" : "Dapagliflozin in HFmrEF or HFpEF",
             "briefDesignDescription" : "PFO closure in cryptogenic stroke",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2206286",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009639",
             "pageid" : 4921,
            "pageid" : 1093,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2206286",
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009639",
             "trainingLevel" : "Resident",
            "trainingLevel" : "Fellow",
             "citation" : "Solomon SD, <i>et al</i>. \"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction\". <i>The New England Journal of Medicine</i>. 2022. 387(12):1089-1098.",
            "citation" : "Furlan AJ, <i>et al</i>. \"Closure or medical therapy for cryptogenic stroke with patent foramen ovale\". <i>The New England Journal of Medicine</i>. 2012. 366(11):991-999.",
            "subspecialties" : "Neurology;Cardiology",
            "expansion" : "Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale",
            "statusUsableDate" : "2013-01-01",
            "briefResultsDescription" : "PFO closure does not reduce recurrent stroke",
            "published" : "2012-03-15",
            "pageName" : "CLOSURE I",
            "diseases" : "Stroke;Patent Foramen Ovale;Transient Ischemic Attack",
            "abbreviation" : "CLOSURE I",
            "title" : "Closure or medical therapy for cryptogenic stroke with patent foramen ovale",
            "pmid" : "22417252"
        },
        {
            "timestamp" : "2018-04-14T12:16:19Z",
            "briefDesignDescription" : "LMWH vs. warfarin in cancer VTE",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa025313",
            "pageid" : 13,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa025313",
            "trainingLevel" : "Intern",
            "citation" : "Lee AY, <i>et al</i>. \"Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer\". <i>The New England Journal of Medicine</i>. 2003. 349(2):146-53.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "Comparison of Low Molecular Weight Heparin Versus Oral Anticoagulant Therapy for Long Term Anticoagulation in Cancer Patients With Venous Thromboembolism",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "LMWH reduces VTE recurrence in cancer VTE without increasing bleeding risk",
            "published" : "2003-07-10",
            "pageName" : "CLOT",
            "diseases" : "Deep Vein Thrombosis;Pulmonary Embolism;Venous Thromboembolism",
            "abbreviation" : "CLOT",
            "title" : "Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer",
            "pmid" : "12853587"
        },
        {
            "timestamp" : "2021-04-29T17:37:05Z",
            "briefDesignDescription" : "Mitra Clip for HF-related MR",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1806640",
             "pageid" : 3714,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1806640",
             "trainingLevel" : "Resident",
             "citation" : "Stone GW, <i>et al</i>. \"Transcatheter Mitral Valve Repair in Patients with Heart Failure\". <i>The New England Journal of Medicine</i>. 2018. 379:2307-2318.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure",
             "expansion" : "Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation",
             "statusUsableDate" : "2022-10-13",
             "statusUsableDate" : "2018-12-19",
             "briefResultsDescription" : "Dapagliflozin reduces HF events in HFmrEF or HFpEF",
             "briefResultsDescription" : "Mitra Clip reduces HF hospitalization rate in HF-related MR",
             "published" : "2022-09-22",
             "published" : "2018-09-23",
             "pageName" : "DELIVER",
             "pageName" : "COAPT",
             "diseases" : "Heart Failure",
             "diseases" : "Mitral Regurgitation",
             "abbreviation" : "DELIVER",
             "abbreviation" : "COAPT",
             "title" : "Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction",
             "title" : "Transcatheter Mitral Valve Repair in Patients with Heart Failure",
             "pmid" : "36027570"
             "pmid" : "30280640"
         },
         },
         {
         {
             "timestamp" : "2018-02-01T20:15:39Z",
             "timestamp" : "2017-12-03T22:34:23Z",
             "briefDesignDescription" : "Oxygen for suspected MI",
             "briefDesignDescription" : "PPI plus clopidogrel in CAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1706222",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1007964",
             "pageid" : 2970,
             "pageid" : 313,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1706222",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1007964",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Hofmann R, <i>et al</i>. \"Oxygen therapy in suspected acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 2017. 377(13):1240-1249.",
             "citation" : "Bhatt DL, <i>et al</i>. \"Clopidogrel with or without omeprazole in coronary artery disease\". <i>The New England Journal of Medicine</i>. 2010. 363(20):1909-17.",
            "subspecialties" : "Cardiology",
            "expansion" : "Clopidogrel and the Optimization of Gastrointestinal Events Trial",
            "statusUsableDate" : "2012-04-01",
            "briefResultsDescription" : "PPIs reduce bleeding but do not increase CV events when given with clopidogrel",
            "published" : "2010-11-11",
            "pageName" : "COGENT",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "COGENT",
            "title" : "Clopidogrel with or without omeprazole in coronary artery disease",
            "pmid" : "20925534"
        },
        {
            "timestamp" : "2021-02-18T20:37:27Z",
            "briefDesignDescription" : "Colchicine vs. placebo in ACS",
            "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1912388",
            "pageid" : 4145,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1912388",
            "trainingLevel" : "Resident",
            "citation" : "Tardif J, <i>et al</i>. \"Efficacy and safety of low-dose colchicine after myocardial infarction\". <i>The New England Journal of Medicine</i>. 2019. 381(26):2497-2505.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction",
             "expansion" : "Colchicine Cardiovascular Outcomes Trial",
             "statusUsableDate" : "2017-10-01",
            "statusUsableDate" : "2019-11-24",
             "briefResultsDescription" : "Oxygen doesn't improve 1 year survival in MI",
            "briefResultsDescription" : "Colchicine superior to placebo in ACS",
             "published" : "2017-09-28",
            "published" : "2019-11-16",
             "pageName" : "DETO2X-AMI",
            "pageName" : "COLCOT",
             "diseases" : "Myocardial Infarction",
            "diseases" : "Acute Coronary Syndrome",
             "abbreviation" : "DETO2X-AMI",
            "abbreviation" : "COLCOT",
             "title" : "Oxygen therapy in suspected acute myocardial infarction",
            "title" : "Efficacy and safety of low-dose colchicine after myocardial infarction",
             "pmid" : "28844200"
            "pmid" : "31733140"
        },
        {
            "timestamp" : "2021-09-16T13:55:19Z",
            "briefDesignDescription" : "FIT vs. colonoscopy for colon cancer screening",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1108895",
            "pageid" : 2393,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1108895",
            "trainingLevel" : "Resident",
            "citation" : "Quintero E, <i>et al</i>. \"Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening\". <i>The New England Journal of Medicine</i>. 2012. 366(8):697-706.",
            "subspecialties" : "Preventive Medicine;Gastroenterology;Oncology",
            "expansion" : null,
             "statusUsableDate" : "2016-07-01",
             "briefResultsDescription" : "FIT is noninferior to colonoscopy for detecting colon cancer",
             "published" : "2012-02-23",
             "pageName" : "COLONPREV",
             "diseases" : "Colorectal Cancer",
             "abbreviation" : "COLONPREV",
             "title" : "Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening",
             "pmid" : "22356323"
         },
         },
         {
         {
             "timestamp" : "2014-06-13T04:50:56Z",
             "timestamp" : "2015-08-24T04:36:50Z",
             "briefDesignDescription" : "Digoxin in HFrEF",
             "briefDesignDescription" : "Carvedilol vs. metoprolol in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199702203360801",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)13800-7/fulltext",
             "pageid" : 89,
             "pageid" : 121,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199702203360801",
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673603138007.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Gorlin R, <i>et al</i>. \"The effect of digoxin on mortality and morbidity in patients with heart failure\". <i>The New England Journal of Medicine</i>. 1997. 336(8):525-533.",
             "citation" : "Poole-Wilson PA, <i>et al</i>. \"Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial\". <i>The Lancet</i>. 2003. 362(9377):7-13.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Digitalis Investigation Group",
             "expansion" : "Carvedilol Or Metoprolol European Trial",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Reduced hospitalizations, no mortality benefit",
             "briefResultsDescription" : "Carvedilol extends survival in HFrEF",
             "published" : "1997-02-20",
             "published" : "2003-07-05",
             "pageName" : "DIG",
             "pageName" : "COMET",
             "diseases" : "Heart Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "DIG",
             "abbreviation" : "COMET",
             "title" : "The effect of digoxin on mortality and morbidity in patients with heart failure",
             "title" : "Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial",
             "pmid" : "9036306"
             "pmid" : "12853193"
         },
         },
         {
         {
             "timestamp" : "2020-09-14T19:26:41Z",
             "timestamp" : "2018-03-08T18:56:18Z",
             "briefDesignDescription" : "ICD for ICM shortly after MI",
             "briefDesignDescription" : "Metoprolol in acute MI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041489",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67661-1/fulltext",
             "pageid" : 1743,
             "pageid" : 1451,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041489",
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673605676611.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Hohnloser SH, <i>et al</i>. \"Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 2004. 351(24):2481-2488.",
             "citation" : "Chen ZM, <i>et al</i>. \"Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial\". <i>The Lancet</i>. 2005. 366(9497):1622-1632.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Defibrillator in Acute Myocardial Infarction Trial",
             "expansion" : "ClOpidogrel and Metoprolol in Myocardial Infarction Trial / Second Chinese Cardiac Study",
             "statusUsableDate" : "2016-04-01",
             "statusUsableDate" : "2013-05-01",
             "briefResultsDescription" : "ICD reduces arrhythmia but not mortality",
             "briefResultsDescription" : "High-dose IV and PO metoprolol increases cardiogenic shock",
             "published" : "2004-12-09",
             "published" : "2005-11-05",
             "pageName" : "DINAMIT",
             "pageName" : "COMMIT",
             "diseases" : "Heart Failure;Myocardial Infarction",
             "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
             "abbreviation" : "DINAMIT",
             "abbreviation" : "COMMIT/CCS-2",
             "title" : "Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction",
             "title" : "Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial",
             "pmid" : "15590950"
             "pmid" : "16271643"
         },
         },
         {
         {
             "timestamp" : "2019-10-17T17:40:21Z",
             "timestamp" : "2018-03-12T00:27:10Z",
             "briefDesignDescription" : "BMS vs. DES for saphenous vein graft PCI",
             "briefDesignDescription" : "Multivessel PCI vs. FFR-guided complete revascularization",
             "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30801-8/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMc1706275",
             "pageid" : 3743,
             "pageid" : 3543,
             "pdfurl" : "",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMc1706275",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Brilakis ES, <i>et al</i>. \"Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial\". <i>Lancet</i>. 2018. 391(10134):1997-2007.",
             "citation" : "Smits PC, <i>et al</i>. \"Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction\". <i>The New England Journal of Medicine</i>. 2017. 376(13):1234-1244.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Rationale and design of the drug-eluting stents vs bare-metal stents in saphenous vein graft angioplasty",
             "expansion" : "",
             "statusUsableDate" : "2018-11-27",
             "statusUsableDate" : "2018-03-11",
             "briefResultsDescription" : "BMS noninferior to DES for saphenous vein graft PCI",
             "briefResultsDescription" : "FFR-guided complete revascularization superior to infarct-related artery only PCI",
             "published" : "2018-05-19",
             "published" : "2017-03-30",
             "pageName" : "DIVA",
             "pageName" : "Compare-Acute",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "DIVA",
             "abbreviation" : "Compare-Acute",
             "title" : "Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial",
             "title" : "Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction",
             "pmid" : "29759512"
             "pmid" : "28745981"
         },
         },
         {
         {
             "timestamp" : "2019-07-18T20:41:06Z",
             "timestamp" : "2024-08-27T16:42:59Z",
             "briefDesignDescription" : "D-dimer based anticoagulation discontinuation",
             "briefDesignDescription" : "Rivaroxaban, ASA, or both in stable CAD",
             "fulltexturl" : "https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14458",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1709118",
             "pageid" : 4089,
             "pageid" : 2955,
             "pdfurl" : "https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14458",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1709118",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Kearon C, <i>et al</i>. \"Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study\". <i>Journal of Thrombosis and Hemostasis</i>. 2019. 17(7):1144-52.",
             "citation" : "Eikelboom JW <i>et al</i>. \"Rivaroxaban with or without aspirin in stable cardiovascular disease\". <i>The New England Journal of Medicine</i>. 2017. 377(14):1319-1330.",
             "subspecialties" : "Hematology",
             "subspecialties" : "Cardiology",
             "expansion" : "D-dimer Optimal Duration Study",
             "expansion" : "Cardiovascular Outcomes for People Using Anticoagulation Stratgies",
             "statusUsableDate" : "2019-07-18",
             "statusUsableDate" : "2017-09-01",
             "briefResultsDescription" : "D-dimer based discontinuation effective in women, not for men",
             "briefResultsDescription" : "Rivaroxaban + ASA superior to placebo + ASA for secondary prevention of CAD",
             "published" : "2019-01-18",
             "published" : "2017-08-27",
             "pageName" : "DODS",
             "pageName" : "COMPASS",
             "diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "DODS",
             "abbreviation" : "COMPASS",
             "title" : "Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study",
             "title" : "Rivaroxaban with or without aspirin in stable cardiovascular disease",
             "pmid" : "31033194"
             "pmid" : "28844192"
         },
         },
         {
         {
             "timestamp" : "2019-05-23T17:58:08Z",
             "timestamp" : "2021-02-20T21:38:07Z",
             "briefDesignDescription" : "Donor HCV positive heart and lung transplant",
             "briefDesignDescription" : "Enalapril in severe HFrEF",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812406",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM198706043162301",
             "pageid" : 4066,
             "pageid" : 18,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812406",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM198706043162301",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Woolley AE, <i>et al</i>. \"Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients\". <i>The New England Journal of Medicine</i>. 2019. 380(17):1606-1617.",
             "citation" : "CONSENSUS Trial Study Group. \"Effects of enalapril on mortality in severe congestive heart failure, results of the cooperative north Scandinavian enalapril survival study\". <i>The New England Journal of Medicine</i>. 1987. 316(23):1429-35.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Donors of Hepatitis C NAT Positive Thoracic Allografts for Transplantation Evaluation in Non-HCV Recipients",
             "expansion" : "Cooperative North Scandinavian Enalapril Survival Study",
             "statusUsableDate" : "2019-05-17",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Donor HCV+ heart & lung transplant is feasible",
             "briefResultsDescription" : "Enalapril ↓mortality in NYHA class IV HFrEF",
             "published" : "2019-04-25",
             "published" : "1987-06-04",
             "pageName" : "DONATE-HCV",
             "pageName" : "CONSENSUS",
             "diseases" : "Heart Failure;Respiratory Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "DONATE HCV",
             "abbreviation" : "CONSENSUS",
             "title" : "Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients",
             "title" : "Effects of enalapril on mortality in severe congestive heart failure, results of the cooperative north Scandinavian enalapril survival study",
             "pmid" : "30946553"
             "pmid" : "2883575"
         },
         },
         {
         {
             "timestamp" : "2022-09-15T20:00:28Z",
             "timestamp" : "2014-06-13T04:33:43Z",
             "briefDesignDescription" : "Diuretic dosing in acute HF",
             "briefDesignDescription" : "Carvedilol in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005419",
             "fulltexturl" : "http://circ.ahajournals.org/content/106/17/2194.full",
             "pageid" : 1457,
             "pageid" : 42,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005419",
             "pdfurl" : "http://circ.ahajournals.org/content/106/17/2194.full.pdf",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Felker GM, <i>et al</i>. \"Diuretic strategies in patients with acute decompensated heart failure\". <i>The New England Journal of Medicine</i>. 2011. 364(9):797-805.",
             "citation" : "Packer M, <i>et al</i>. \"Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure\". <i>Circulation</i>. 2002. 106(17):2194-9.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Diuretic Optimization Strategies Evaluation",
             "expansion" : "Carvedilol Prospective Randomized Cumulative Survival",
             "statusUsableDate" : "2013-06-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "High-dose better than low-dose, continuous infusions no better than intermittent IV boluses",
             "briefResultsDescription" : "Carvedilol reduces mortality and HF hospitalizations in severe NYHA class III-IV HFrEF",
             "published" : "2011-03-03",
             "published" : "2002-10-22",
             "pageName" : "DOSE",
             "pageName" : "COPERNICUS",
             "diseases" : "Heart Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "DOSE",
             "abbreviation" : "COPERNICUS",
             "title" : "Diuretic strategies in patients with acute decompensated heart failure",
             "title" : "Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure",
             "pmid" : "21366472"
             "pmid" : "12390947"
         },
         },
         {
         {
             "timestamp" : "2018-05-31T18:34:46Z",
            "timestamp" : "2019-11-07T19:27:29Z",
             "briefDesignDescription" : "Metformin and intensive lifestyle in prediabetes",
            "briefDesignDescription" : "Stenting vs. medical therapy in RAS",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa012512",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310753",
             "pageid" : 2494,
            "pageid" : 2388,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa012512",
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310753",
            "trainingLevel" : "Intern",
            "citation" : "Cooper CJ, <i>et al</i>. \"Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis\". <i>The New England Journal of Medicine</i>. 2014. 370(1):13-22.",
            "subspecialties" : "Nephrology;Cardiology",
            "expansion" : "Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis",
            "statusUsableDate" : "2019-11-07",
            "briefResultsDescription" : "No difference in clinical outcomes",
            "published" : "2014-01-02",
            "pageName" : "CORAL",
            "diseases" : "Cardiovascular Disease;Chronic Kidney Disease;Hypertension",
            "abbreviation" : "CORAL",
            "title" : "Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis",
            "pmid" : "24245566"
        },
        {
            "timestamp" : "2017-12-03T22:34:30Z",
            "briefDesignDescription" : "Rosuvastatin in ischemic HFrEF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0706201",
            "pageid" : 524,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0706201",
            "trainingLevel" : "Resident",
            "citation" : "Kjekshus J, <i>et al</i>. \"Rosuvastatin in Older Patients with Systolic Heart Failure\". <i>The New England Journal of Medicine</i>. 2007. 357(22):2248-61.",
            "subspecialties" : "Cardiology",
            "expansion" : "Controlled Rosuvastatin Multinational Trial in Heart Failure",
            "statusUsableDate" : "2012-07-01",
            "briefResultsDescription" : "Statins confer no survival benefit but may reduce hospitalizations in ischemic HFrEF",
            "published" : "2007-11-29",
            "pageName" : "CORONA",
            "diseases" : "Heart Failure;Hyperlipidemia",
            "abbreviation" : "CORONA",
            "title" : "Rosuvastatin in Older Patients with Systolic Heart Failure",
            "pmid" : "17984166"
        },
        {
             "timestamp" : "2018-03-03T22:13:51Z",
             "briefDesignDescription" : "Hydrocortisone in septic shock",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa071366",
             "pageid" : 4,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa071366",
             "trainingLevel" : "Student",
             "trainingLevel" : "Student",
             "citation" : "Knowler WC, <i>et al</i>. \"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin\". <i>The New England Journal of Medicine</i>. 2002. 346(6):393-403.",
             "citation" : "Sprung CL, <i>et al</i>. \"Hydrocortisone therapy for patients with septic shock\". <i>New England Journal of Medicine</i>. 2008. 358(2):111-24.",
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Critical Care;Endocrinology",
             "expansion" : "Diabetes Prevention Program",
             "expansion" : "Corticosteroid Therapy of Septic Shock",
             "statusUsableDate" : "2018-05-31",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Metformin and intensive lifestyle reduce incidence of diabetes",
             "briefResultsDescription" : "Improved survival of hydrocortisone in septic shock",
             "published" : "2002-02-07",
             "published" : "2008-01-10",
             "pageName" : "DPP",
             "pageName" : "CORTICUS",
             "diseases" : "Prediabetes;Diabetes Mellitus",
             "diseases" : "Sepsis;Shock",
             "abbreviation" : "DPP",
             "abbreviation" : "CORTICUS",
             "title" : "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin",
             "title" : "Hydrocortisone therapy for patients with septic shock",
             "pmid" : "11832527"
             "pmid" : "18184957"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:03Z",
             "timestamp" : "2017-12-14T14:38:53Z",
             "briefDesignDescription" : "Duct tape vs. cryotherapy for warts",
             "briefDesignDescription" : "PCI vs. medical therapy in CAD",
             "fulltexturl" : "",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa070829",
             "pageid" : 1579,
             "pageid" : 21,
             "pdfurl" : "http://archpedi.jamanetwork.com/data/Journals/PEDS/5052/POA20075.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa070829",
             "trainingLevel" : "Student",
             "trainingLevel" : "Student",
             "citation" : "Focht DR, <i>et al</i>. \"The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)\". <i>Archives of Pediatric and Adolescent Medicine</i>. 2002. 156:971-974.",
             "citation" : "Boden WE, <i>et al</i>. \"Optimal medical therapy with or without PCI for stable coronary disease\". <i>The New England Journal of Medicine</i>. 2007. 356:1503-16.",
             "subspecialties" : "Pediatrics;Dermatology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation",
             "statusUsableDate" : "2013-07-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Duct tape superior to cryotherapy for wart resolution",
             "briefResultsDescription" : "No difference between PCI and OMT in stable CAD",
             "published" : "2002-10-01",
             "published" : "2007-04-12",
             "pageName" : "Duct Tape for Treatment of the Common Wart",
             "pageName" : "COURAGE",
             "diseases" : "Warts",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "",
             "abbreviation" : "COURAGE",
             "title" : "The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)",
             "title" : "Optimal medical therapy with or without PCI for stable coronary disease",
             "pmid" : "12361440"
             "pmid" : "17387127"
         },
         },
         {
         {
             "timestamp" : "2018-03-29T18:30:43Z",
             "timestamp" : "2017-12-03T22:34:43Z",
             "briefDesignDescription" : "Fecal transplant in C. difficile",
             "briefDesignDescription" : "Cranberry in for prevention of pyuria and bacteriuria",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205037",
             "fulltexturl" : "https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.16141",
             "pageid" : 1226,
             "pageid" : 2900,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205037",
             "pdfurl" : "",
             "trainingLevel" : "Intern",
             "trainingLevel" : "student",
             "citation" : "Van Nood E, <i>et al</i>. \"Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile\". <i>The New England Journal of Medicine</i>. 2013. 368(5):407-415.",
             "citation" : "Juthani-Mehta M, <i>et al</i>. \"Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial\". <i>JAMA</i>. 2016. 316(18):1879-1887.",
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "subspecialties" : "Infectious Disease;Geriatrics",
             "expansion" : "",
             "expansion" : "",
             "statusUsableDate" : "2013-02-01",
             "statusUsableDate" : "2017-04-01",
             "briefResultsDescription" : "Fecal transplant better than vancomycin in C. difficile",
             "briefResultsDescription" : "Cranberry ineffective to prevent pyuria and bacteriuria",
             "published" : "2013-01-31",
             "published" : "2016-11-08",
             "pageName" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
             "pageName" : "Cranberry for prevention of pyuria and bacteriuria",
             "diseases" : "Clostridium difficile",
             "diseases" : "Bacteriuria;Pyuria",
             "abbreviation" : "",
             "abbreviation" : "",
             "title" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
             "title" : "Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: A randomized clinical trial",
             "pmid" : "23323867"
             "pmid" : "27787564"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:32Z",
             "timestamp" : "2022-12-01T18:56:37Z",
             "briefDesignDescription" : "Palliative care in NSCLC",
             "briefDesignDescription" : "Tranexamic acid in trauma",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000678",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960835-5/fulltext",
             "pageid" : 466,
            "pageid" : 490,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000678",
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673610608355.pdf",
             "trainingLevel" : "Intern",
            "trainingLevel" : "resident",
             "citation" : "Temel JS, <i>et al</i>. \"Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer\". <i>The New England Journal of Medicine</i>. 2010. 363(8):733-742.",
            "citation" : "Shakur H, <i>et al</i>. \"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage\". <i>The Lancet</i>. 2010. 376(9734):23-32.",
             "subspecialties" : "Oncology;Palliative Care",
            "subspecialties" : "Emergency Medicine;Surgery;Hematology",
             "expansion" : null,
            "expansion" : "Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2",
             "statusUsableDate" : "2012-06-01",
            "statusUsableDate" : "2013-07-01",
             "briefResultsDescription" : "Palliative care ↑mood, ↑QOL, ↑survival, ↓aggressive care",
            "briefResultsDescription" : "Tranexamic acid reduces 4-week mortality",
             "published" : "2010-08-19",
            "published" : "2010-07-03",
             "pageName" : "Early Palliative Care",
            "pageName" : "CRASH-2",
             "diseases" : "Lung Cancer",
            "diseases" : "Trauma",
             "abbreviation" : null,
            "abbreviation" : "CRASH-2",
             "title" : "Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer",
            "title" : "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage",
             "pmid" : "20818875"
            "pmid" : "20554319"
        },
        {
            "timestamp" : "2022-06-17T05:34:20Z",
            "briefDesignDescription" : "Ide-cel CART in myeloma",
            "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1817226",
             "pageid" : 4096,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817226",
             "trainingLevel" : "Fellow",
             "citation" : "Raje N, <i>et al</i>. \"Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma\". <i>The New England Journal of Medicine</i>. 2019. 380(18):1726-1737.",
             "subspecialties" : "Hematology;Oncology",
             "expansion" : "",
             "statusUsableDate" : "2022-06-16",
             "briefResultsDescription" : "CRS 76%, ORR 85%, PFS 11.8 months",
             "published" : "2019-05-02",
             "pageName" : "CRB-401",
             "diseases" : "Multiple Myeloma",
             "abbreviation" : "CRB-401",
             "title" : "Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma",
             "pmid" : "31042825"
         },
         },
         {
         {
             "timestamp" : "2018-08-30T17:24:07Z",
             "timestamp" : "2019-10-15T19:28:09Z",
             "briefDesignDescription" : "Early TIPS in high-risk cirrhotic variceal bleeding",
             "briefDesignDescription" : "Canagliflozin in diabetic nephropathy",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910102",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1811744",
             "pageid" : 2661,
             "pageid" : 4088,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910102",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1811744",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "García-Pagán JC, <i>et al</i>. \"Early use of TIPS in patients with cirrhosis and variceal bleeding\". <i>The New England Journal of Medicine</i>. 2010. 362(25):2370-2379.",
             "citation" : "Perkovic V, <i>et al</i>. \"Canagliflozin and renal outcomes in diabetic nephropathy\". <i>The New England Journal of Medicine</i>. 2019. 380(24):2295-2306.",
             "subspecialties" : "Gastroenterology;Interventional Radiology",
             "subspecialties" : "Endocrinology;Nephrology",
             "expansion" : "",
             "expansion" : "Canagliflozin and Renal Events in Diabetes and Nephropathy Clinical Evaluation",
             "statusUsableDate" : "2018-08-30",
             "statusUsableDate" : "2019-07-31",
             "briefResultsDescription" : "Early TIPS reduces rates of treatment failure and improves 1-year survival",
             "briefResultsDescription" : "Canagliflozin reduces renal and CVD endpoints vs. placebo",
             "published" : "2010-06-24",
            "published" : "2019-06-13",
             "pageName" : "Early TIPS",
            "pageName" : "CREDENCE",
             "diseases" : "Cirrhosis;Gastrointestinal Hemorrhage",
            "diseases" : "Diabetes Mellitus;Diabetic Nephropathy",
             "abbreviation" : "Early TIPS",
            "abbreviation" : "CREDENCE",
             "title" : "Early use of TIPS in patients with cirrhosis and variceal bleeding",
            "title" : "Canagliflozin and renal outcomes in diabetic nephropathy",
             "pmid" : "20573925"
            "pmid" : "30990260"
        },
        {
            "timestamp" : "2019-01-30T21:43:56Z",
            "briefDesignDescription" : "Stenting vs. CEA in carotid stenosis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0912321",
            "pageid" : 492,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0912321",
            "trainingLevel" : "Intern",
            "citation" : "Brott TG, <i>et al</i>. \"Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis\". <i>The New England Journal of Medicine</i>. 2010. 363(1):11-23.",
            "subspecialties" : "Surgery;Neurology;Cardiology",
            "expansion" : "Carotid Revascularization Endarterectomy vs. Stenting Trial",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "No difference in stroke/MI/death; stenting ↑perioperative stroke but ↓perioperative MI",
             "published" : "2010-07-01",
             "pageName" : "CREST",
             "diseases" : "Carotid Stenosis;Stroke;Transient Ischemic Attack",
            "abbreviation" : "CREST",
            "title" : "Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis",
            "pmid" : "20505173"
        },
        {
            "timestamp" : "2017-12-03T22:34:32Z",
            "briefDesignDescription" : "Colloids vs. crystalloids in shock",
            "fulltexturl" : "http://bit.ly/1kLbQWJ",
            "pageid" : 1768,
            "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/928522/joi130081.pdf",
            "trainingLevel" : "resident",
            "citation" : "Annane D, <i>et al</i>. \"Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock\". <i>The Journal of the American Medical Association</i>. 2013. 310(17):1809-1817.",
            "subspecialties" : "Critical Care",
            "expansion" : "Colloids Versus Crystalloids for the Resuscitation of the Critically Ill",
            "statusUsableDate" : "2014-07-01",
            "briefResultsDescription" : "Colloids no different from crystalloids in mortality",
            "published" : "2013-11-06",
            "pageName" : "CRISTAL",
            "diseases" : "Shock",
             "abbreviation" : "CRISTAL",
             "title" : "Effects of fluid resuscitation with colloids vs. crystalloids on mortality in critically ill patients presenting with hypovolemic shock",
            "pmid" : "24108515"
        },
        {
            "timestamp" : "2021-04-22T22:10:39Z",
            "briefDesignDescription" : "Captopril in T1DM nephropathy",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199311113292004",
            "pageid" : 1591,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199311113292004",
            "trainingLevel" : "Student",
            "citation" : "Lewis EJ, <i>et al</i>. \"The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.\". <i>The New England Journal of Medicine</i>. 1993. 329(20):1456-1462.",
            "subspecialties" : "Nephrology;Endocrinology",
            "expansion" : "Collaborative Study Group Captopril Trial",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "Captopril reduces T1DM nephropathy progression",
            "published" : "1993-11-11",
            "pageName" : "CSG Captopril Trial",
            "diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
            "abbreviation" : "CSG Captopril Trial",
            "title" : "The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.",
             "pmid" : "8413456"
         },
         },
         {
         {
             "timestamp" : "2021-11-08T18:52:31Z",
             "timestamp" : "2018-08-28T15:50:00Z",
             "briefDesignDescription" : "Cryoablation vs. antiarrhythmics in AF",
             "briefDesignDescription" : "Culprit-only vs. multivessel PCI in cardiogenic shock",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1710261#t",
             "pageid" : 4406,
             "pageid" : 2977,
             "pdfurl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1710261#t",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Andrade J, <i>et al</i>. \"Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2021. 384(4):305-315.",
             "citation" : "Thiele H, <i>et al</i>. \"PCI strategies in patients with acute myocardial infarction and cardiogenic shock\". <i>New England Journal of Medicine</i>. 2017. epub 2017-10-30:1-13.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Early Aggressive Invasive Intervention for Atrial Fibrillation",
             "expansion" : "Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock",
             "statusUsableDate" : "2021-10-14",
             "statusUsableDate" : "2017-11-01",
             "briefResultsDescription" : "Cryoablation with lower tachyarrhythmia recurrence than antiarrhythmics.",
             "briefResultsDescription" : "Culprit-only PCI superior to multivessel PCI in cardiogenic shock",
             "published" : "2021-01-28",
             "published" : "2017-10-30",
             "pageName" : "EARLY-AF",
             "pageName" : "CULPRIT-SHOCK",
             "diseases" : "Atrial Fibrillation",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "EARLY-AF",
             "abbreviation" : "CULPRIT-SHOCK",
             "title" : "Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation",
             "title" : "PCI strategies in patients with acute myocardial infarction and cardiogenic shock",
             "pmid" : "33197159"
             "pmid" : "29083953"
         },
         },
         {
         {
             "timestamp" : "2019-09-19T17:42:49Z",
             "timestamp" : "2017-12-03T22:34:36Z",
             "briefDesignDescription" : "Early surgery in endocarditis",
             "briefDesignDescription" : "Clopidogrel in UA/NSTEMI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112843",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa010746",
             "pageid" : 2939,
             "pageid" : 921,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112843",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa010746",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Kang DH, <i>et al</i>. \"Early surgery versus conventional treatment for infective endocarditis\". <i>The New England Journal of Medicine</i>. 2012. 366(26):2466-73.",
             "citation" : "Yusuf S, <i>et al</i>. \"Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation\". <i>The New England Journal of Medicine</i>. 2001. 345(7):494-502.",
             "subspecialties" : "Cardiology;Infectious Disease;Surgery",
             "subspecialties" : "Cardiology",
             "expansion" : "Early Surgery versus Conventional Treatment in Infective Endocarditis",
             "expansion" : "Clopidogrel in Unstable Angina to Prevent Recurrent Events",
             "statusUsableDate" : "2019-09-19",
             "statusUsableDate" : "2012-12-01",
             "briefResultsDescription" : "Early surgery improves outcomes in infective endocarditis",
             "briefResultsDescription" : "Clopidogrel reduces CV events but increases bleeding in UA/NSTEMI",
             "published" : "2012-06-28",
             "published" : "2001-08-16",
             "pageName" : "EASE",
             "pageName" : "CURE",
             "diseases" : "Endocarditis",
             "diseases" : "Acute Coronary Syndrome",
             "abbreviation" : "EASE",
             "abbreviation" : "CURE",
             "title" : "Early surgery versus conventional treatment for infective endocarditis",
             "title" : "Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation",
             "pmid" : "22738096"
             "pmid" : "11519503"
         },
         },
         {
         {
             "timestamp" : "2021-02-09T14:57:23Z",
             "timestamp" : "2017-12-03T22:34:45Z",
             "briefDesignDescription" : "Early rhythm vs. rate control in AF",
             "briefDesignDescription" : "Culprit lesion-only vs. complete revascularization",
             "fulltexturl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
             "fulltexturl" : "http://www.onlinejacc.org/content/65/10/963",
             "pageid" : 4399,
             "pageid" : 2880,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
             "pdfurl" : "http://www.onlinejacc.org/content/accj/65/10/963.full.pdf?download",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Kirchhof P, <i>et al</i>. \"Early rhythm-control therapy in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2020. 383(14):1305-1316.",
             "citation" : "Gershlick <i>et al</i>. \"Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease\". <i>J Am Coll Cardiol</i>. 2015. 65(10):963-72.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial",
             "expansion" : "Complete Versus Lesion-Only Primary PCI Trial",
             "statusUsableDate" : "2021-01-28",
             "statusUsableDate" : "2017-02-01",
             "briefResultsDescription" : "Early rhythm control with fewer CVD events.",
            "briefResultsDescription" : "Complete revascularization superior to culprit lesion-only revascularization",
             "published" : "2020-10-01",
            "published" : "2015-03-17",
             "pageName" : "EAST-AFNET 4",
            "pageName" : "CvLPRIT",
             "diseases" : "Atrial Fibrillation",
            "diseases" : "Coronary Artery Disease",
             "abbreviation" : "EAST-AFNET 4",
            "abbreviation" : "CvLPRIT",
             "title" : "Early rhythm-control therapy in patients with atrial fibrillation",
            "title" : "Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease",
             "pmid" : "32865375"
            "pmid" : "25766941"
        },
        {
            "timestamp" : "2017-12-03T22:34:37Z",
            "briefDesignDescription" : "Pulse cyclophosphamide for ANCA vasculitis",
            "fulltexturl" : null,
            "pageid" : 2338,
             "pdfurl" : "http://annals.org/data/Journals/AIM/20182/0000605-200905190-00004.pdf",
            "trainingLevel" : "Fellow",
             "citation" : "de Groot K, <i>et al</i>. \"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial\". <i>Annals of Internal Medicine</i>. 2009. 150(10):670-680.",
            "subspecialties" : "Rheumatology;Nephrology",
            "expansion" : null,
            "statusUsableDate" : "2015-03-01",
            "briefResultsDescription" : "Pulse no worse than daily cyclophosphamide",
            "published" : "2009-05-19",
             "pageName" : "CYCLOPS",
             "diseases" : "Vasculitis",
             "abbreviation" : "CYCLOPS",
             "title" : "Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial",
             "pmid" : "19451574"
         },
         },
         {
         {
             "timestamp" : "2017-04-20T01:11:46Z",
             "timestamp" : "2018-01-13T01:32:16Z",
             "briefDesignDescription" : "Alteplase 3-4.5h after stroke",
             "briefDesignDescription" : "Cytisine vs. NRT for tobacco abuse",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804656",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1407764",
             "pageid" : 115,
             "pageid" : 2319,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804656",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407764",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Hacke W, <i>et al</i>. \"Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke\". <i>The New England Journal of Medicine</i>. 2008. 359(13):1317-1329.",
             "citation" : "Walker N, <i>et al</i>. \"Cytisine versus nicotine for smoking cessation\". <i>The New England Journal of Medicine</i>. 2014. 371(25):2353-2362.",
             "subspecialties" : "Neurology",
             "subspecialties" : "Pulmonology;Preventive Medicine",
             "expansion" : "European Cooperative Acute Stroke Study III",
             "expansion" : null,
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2015-01-01",
             "briefResultsDescription" : "Alteplase improves neurological outcomes at 3 months",
             "briefResultsDescription" : "Cytisine superior to NRT for abstinence at 1 month",
             "published" : "2008-09-25",
             "published" : "2014-12-18",
             "pageName" : "ECASS III",
             "pageName" : "Cytisine for Smoking Cessation",
             "diseases" : "Stroke",
             "diseases" : "Tobacco Abuse",
             "abbreviation" : "ECASS III",
             "abbreviation" : null,
             "title" : "Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke",
             "title" : "Cytisine versus nicotine for smoking cessation",
             "pmid" : "18815396"
             "pmid" : "25517706"
         },
         },
         {
         {
             "timestamp" : "2024-06-27T17:56:09Z",
             "timestamp" : "2017-12-03T22:34:39Z",
             "briefDesignDescription" : "Levetiracetam vs. phenytoin in status epilepticus",
             "briefDesignDescription" : "Hematocrit thresholds in PV",
             "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30724-X/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208500",
             "pageid" : 4086,
             "pageid" : 2709,
             "pdfurl" : "https://www.thelancet.com/action/showPdf?pii",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208500",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Fellow",
             "citation" : "Lyttle MD, <i>et al</i>. \"Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.\". <i>Lancet</i>. 2019. 393(10186):2125-2134.",
             "citation" : "Marchioli R, <i>et al</i>. \"Cardiovascular events and intensity of treatment in polycythemia vera\". <i>The New England Journal of Medicine</i>. 2013. 368(1):22-33.",
             "subspecialties" : "Emergency Medicine;Pediatrics;Neurology",
             "subspecialties" : "Hematology;Cardiology",
             "expansion" : "Emergency treatment with Levetiracetam or Phenytoin in convulsive Status Epilepticus in children",
             "expansion" : "Cytoreductive Therapy in Polycythemia Vera",
             "statusUsableDate" : "2024-05-16",
             "statusUsableDate" : "2016-02-01",
             "briefResultsDescription" : "Levetiracetam is non-inferior to phenytoin",
             "briefResultsDescription" : "Fewer vascular events with hematocrit <45% compared to 45-50%",
             "published" : "2019-05-25",
             "published" : "2013-01-03",
             "pageName" : "EcLiPSE",
             "pageName" : "CYTO-PV",
             "diseases" : "Status Epilepticus",
             "diseases" : "Polycythemia Vera;Myeloproliferative Neoplasms",
             "abbreviation" : "EcLiPSE",
             "abbreviation" : "CYTO-PV",
             "title" : "Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.",
             "title" : "Cardiovascular events and intensity of treatment in polycythemia vera",
             "pmid" : "31005385"
             "pmid" : "23216616"
         },
         },
         {
         {
             "timestamp" : "2020-08-01T19:26:48Z",
             "timestamp" : "2017-12-03T22:35:01Z",
             "briefDesignDescription" : "CEA in symptomatic carotid stenosis",
             "briefDesignDescription" : "Scheduled daily sedation holidays in intubated patients",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2909292-1",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200005183422002",
             "pageid" : 2354,
             "pageid" : 1554,
             "pdfurl" : "",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200005183422002",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "ECST Writers. \"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)\". <i>The Lancet</i>. 1998. 351(9113):1379-1387.",
             "citation" : "Kress JP, <i>et al</i>. \"Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation\". <i>The New England Journal of Medicine</i>. 2000. 342(20):1471-1477.",
             "subspecialties" : "Surgery;Neurology",
             "subspecialties" : "Critical Care;Pulmonology",
             "expansion" : "European Carotid Surgery Trial",
             "expansion" : "",
             "statusUsableDate" : "2015-08-01",
             "statusUsableDate" : "2013-08-01",
             "briefResultsDescription" : "CEA improves outcomes in patients with ≥80% symptomatic carotid stenosis",
             "briefResultsDescription" : "Sedation holidays reduce intubated, ICU, hospital days",
             "published" : "1998-05-09",
            "published" : "2000-05-18",
             "pageName" : "ECST",
            "pageName" : "Daily ICU Sedation Holidays",
             "diseases" : "Carotid Stenosis;Stroke",
            "diseases" : "Respiratory Failure",
             "abbreviation" : "ECST",
            "abbreviation" : "",
             "title" : "Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)",
            "title" : "Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation",
             "pmid" : "9593407"
            "pmid" : "10816184"
         },
        },
        {
            "timestamp" : "2018-05-31T17:39:19Z",
            "briefDesignDescription" : "Culprit lesion PCI vs. FFR in multivessel CAD",
            "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60648-1/fulltext",
            "pageid" : 3634,
            "pdfurl" : "https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60648-1.pdf",
            "trainingLevel" : "Resident",
            "citation" : "Engstrom T, <i>et al</i>. \"Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease\". <i>The Lancet</i>. 2015. 386:665-71.",
            "subspecialties" : "Cardiology",
            "expansion" : "Third Danish Study of Optimal Acute Treatment of Patients with STEMI: Primary PCI in Multivessel Disease",
            "statusUsableDate" : "2018-05-28",
            "briefResultsDescription" : "FFR-guided revascularization was superior to culprit-lesion only in multivessel CAD",
             "published" : "2015-08-15",
             "pageName" : "DANAMI-3 PRIMULTI",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "DANAMI-3 PRIMULTI",
             "title" : "Complete Revascularization Versus Treatment of the Culprit Lesion Only in Patients with ST-segment Elevation Myocardial Infarction and Multivessel Disease",
             "pmid" : "26347918"
         },
         {
         {
             "timestamp" : "2013-03-12T08:18:42Z",
             "timestamp" : "2017-12-03T22:34:48Z",
             "briefDesignDescription" : "Intensive glycemic therapy in T1DM",
             "briefDesignDescription" : "ICD vs. standard care in NICM and LVEF ≤35%",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052187",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1608029",
             "pageid" : 136,
             "pageid" : 2815,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052187",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1608029",
             "trainingLevel" : "intern",
             "trainingLevel" : "Resident",
             "citation" : "Nathan DM, <i>et al</i>. \"Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes\". <i>The New England Journal of Medicine</i>. 2005. 353(25):2643-2653.",
             "citation" : "Kober L, <i>et al</i>. \"Defibrillator implantation in patients with nonischemic systolic heart failure\". <i>The New England Journal of Medicine</i>. 2016. epub 2016-08-28:1-10.",
             "subspecialties" : "Endocrinology",
             "subspecialties" : "Cardiology",
             "expansion" : "Epidemiology of Diabetes Interventions and Complications",
             "expansion" : "Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2016-09-01",
             "briefResultsDescription" : "Intensive therapy associated with fewer cardiovascular complications",
             "briefResultsDescription" : "ICD not better than standard of care in NICM and LVEF ≤35%",
             "published" : "2005-12-22",
             "published" : "2016-08-28",
             "pageName" : "EDIC",
             "pageName" : "DANISH",
             "diseases" : "Diabetes Mellitus",
             "diseases" : "Ventricular Tachycardia",
             "abbreviation" : "EDIC",
             "abbreviation" : "DANISH",
             "title" : "Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes",
             "title" : "Defibrillator implantation in patients with nonischemic systolic heart failure",
             "pmid" : "16371630"
             "pmid" : "27571011"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:08Z",
             "timestamp" : "2021-05-28T02:47:35Z",
             "briefDesignDescription" : "Rivaroxaban after VTE treatment",
             "briefDesignDescription" : "Dapagliflozin in CKD±T2DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700518",
            "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2024816",
             "pageid" : 2927,
            "pageid" : 4363,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700518",
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024816",
            "trainingLevel" : "resident",
            "citation" : "Heerspink, <i>et al</i>. \"Dapagliflozin in patients with chronic kidney disease\". <i>The New England Journal of Medicine</i>. 2020. 383(13):1436-1446.",
            "subspecialties" : "Nephrology;Cardiology",
            "expansion" : "Dapagliflozin in Chronic Kidney Disease",
            "statusUsableDate" : "2020-10-29",
            "briefResultsDescription" : "Dapagliflozin in CKD reduces renal endpoints and CVD death",
            "published" : "2020-10-08",
            "pageName" : "DAPA-CKD",
            "diseases" : "Chronic Kidney Disease",
            "abbreviation" : "DAPA-CKD",
            "title" : "Dapagliflozin in patients with chronic kidney disease",
            "pmid" : "32970396"
        },
        {
            "timestamp" : "2022-10-13T18:58:46Z",
            "briefDesignDescription" : "Dapagliflozin in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1911303",
             "pageid" : 4113,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1911303",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Weitz JI, <i>et al</i>. \"Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2017. 376(13):1211-22.",
             "citation" : "McMurray JJV, <i>et al</i>. \"Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction\". <i>The New England Journal of Medicine</i>. 2019. 381(21):1995-2008.",
             "subspecialties" : "Hematology",
             "subspecialties" : "Cardiology;Endocrinology",
             "expansion" : "Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic Venous Thromboembolism",
             "expansion" : "Dapagliflozin in Heart Failure",
             "statusUsableDate" : "2017-07-01",
             "statusUsableDate" : "2019-12-12",
             "briefResultsDescription" : "Rivaroxaban reduces recurrent VTE",
             "briefResultsDescription" : "Dapagliflozin reduces CV complications in HFrEF",
             "published" : "2017-03-30",
             "published" : "2019-11-21",
             "pageName" : "EINSTEIN CHOICE",
             "pageName" : "DAPA-HF",
             "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
             "diseases" : "Heart Failure",
             "abbreviation" : "EINSTEIN CHOICE",
             "abbreviation" : "DAPA-HF",
             "title" : "Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism",
             "title" : "Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction",
             "pmid" : "28316279"
             "pmid" : "31535829"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:09Z",
             "timestamp" : "2017-12-03T22:34:50Z",
             "briefDesignDescription" : "Rivaroxaban vs. warfarin in PE",
             "briefDesignDescription" : "Aspirin/clopidogrel duration after PCI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1113572",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1409312",
             "pageid" : 1519,
             "pageid" : 2264,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1113572",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1409312",
             "trainingLevel" : "Student",
             "trainingLevel" : "Intern",
             "citation" : "Büller HR, <i>et al</i>. \"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism\". <i>The New England Journal of Medicine</i>. 2012. 366(14):1287-1297.",
             "citation" : "Mauri L, <i>et al</i>. \"Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents\". <i>The New England Journal of Medicine</i>. 2014. 371(23):2155-2166.",
             "subspecialties" : "Hematology;Pulmonology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Dual Antiplatelet Therapy",
             "statusUsableDate" : "2013-07-01",
             "statusUsableDate" : "2014-11-01",
             "briefResultsDescription" : "Rivaroxaban is noninferior to warfarin in PE treatment",
             "briefResultsDescription" : "Longer duration reduces stent thrombosis, MI, stroke, but increases mortality/bleeding",
             "published" : "2012-04-05",
             "published" : "2014-11-16",
             "pageName" : "EINSTEIN-PE",
             "pageName" : "DAPT",
             "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
             "diseases" : "Coronary Artery Disease;Myocardial Infarction;Stroke",
             "abbreviation" : "EINSTEIN-PE",
             "abbreviation" : "DAPT",
             "title" : "Oral rivaroxaban for the treatment of symptomatic pulmonary embolism",
             "title" : "Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents",
             "pmid" : "22449293"
             "pmid" : "25399658"
         },
         },
         {
         {
             "timestamp" : "2018-05-27T16:17:38Z",
             "timestamp" : "2020-09-22T18:22:21Z",
             "briefDesignDescription" : "Immunosuppression after kidney transplant",
             "briefDesignDescription" : "DASH diet in HTN",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067411",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199704173361601",
             "pageid" : 2324,
             "pageid" : 90,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067411",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199704173361601",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Ekberg H, <i>et al</i>. \"Reduced exposure to calcineurin inhibitors in renal transplantation\". <i>The New England Journal of Medicine</i>. 2007. 357(25):2562-2575.",
             "citation" : "Appel LJ, <i>et al</i>. \"A clinical trial of the effects of dietary patterns on blood pressure\". <i>The New England Journal of Medicine</i>. 1997. 336(16):1117-1124.",
             "subspecialties" : "Nephrology",
             "subspecialties" : "Cardiology;Nephrology",
             "expansion" : "Efficacy Limiting Toxicity Elimination-Symphony",
             "expansion" : "Dietary Approaches to Stop Hypertension",
             "statusUsableDate" : "2015-02-01",
             "statusUsableDate" : "2012-04-01",
             "briefResultsDescription" : "Daclizumab, mycophenolate, steroids, and tacrolimus beneficial",
             "briefResultsDescription" : "DASH diet reduces SBP and DBP",
             "published" : "2007-12-20",
             "published" : "1997-04-17",
             "pageName" : "ELITE-Symphony",
             "pageName" : "DASH",
             "diseases" : "Kidney Transplant",
             "diseases" : "Hypertension",
             "abbreviation" : "ELITE-Symphony",
             "abbreviation" : "DASH",
             "title" : "Reduced exposure to calcineurin inhibitors in renal transplantation",
             "title" : "A clinical trial of the effects of dietary patterns on blood pressure",
             "pmid" : "18094377"
             "pmid" : "9099655"
         },
         },
         {
         {
             "timestamp" : "2018-09-13T17:28:08Z",
             "timestamp" : "2017-12-03T22:34:54Z",
             "briefDesignDescription" : "Extended EKG monitoring after cryptogenic stroke",
             "briefDesignDescription" : "Dual-chamber vs. ventricular backup pacing in ICD patients",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1311376",
             "fulltexturl" : "http://jama.jamanetwork.com/article.aspx?volume",
             "pageid" : 2403,
             "pageid" : 2713,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1311376",
             "pdfurl" : null,
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Gladstone DJ, <i>et al</i>. \"Atrial Fibrillation in Patients with Cryptogenic Stroke\". <i>The New England Journal of Medicine</i>. 2014. 370(26):2467-2477.",
             "citation" : "Wilkoff BL, <i>et al</i>. \"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator\". <i>Journal of the American Medical Association</i>. 2002. 288(24):3115-3123.",
             "subspecialties" : "Neurology;Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event",
             "expansion" : "Dual-chamber pacing or ventricular backup pacing in ICD patients",
             "statusUsableDate" : "2018-09-13",
             "statusUsableDate" : "2016-08-01",
             "briefResultsDescription" : "Extended EKG monitoring detects AF more frequently than 24-hour monitoring",
             "briefResultsDescription" : "Ventricular backup pacemaker superior to dual-chamber pacemaker",
             "published" : "2014-06-26",
             "published" : "2002-12-25",
             "pageName" : "EMBRACE",
             "pageName" : "DAVID",
             "diseases" : "Stroke;Atrial Fibrillation",
             "diseases" : "Bradycardia",
             "abbreviation" : "EMBRACE",
             "abbreviation" : "DAVID",
             "title" : "Atrial Fibrillation in Patients with Cryptogenic Stroke",
             "title" : "Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator",
             "pmid" : "24963566"
             "pmid" : "12495391"
         },
         },
         {
         {
             "timestamp" : "2021-07-28T13:09:44Z",
             "timestamp" : "2020-01-25T11:34:00Z",
             "briefDesignDescription" : "T-DM1 in metastatic breast cancer",
             "briefDesignDescription" : "Thrombectomy 6-24 hours after stroke",
             "fulltexturl" : "http://www.nejm.org/doi/abs/10.1056/NEJMoa1209124",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1706442",
             "pageid" : 1257,
             "pageid" : 3529,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1209124",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1706442",
             "trainingLevel" : "fellow",
             "trainingLevel" : "Resident",
             "citation" : "Verma S, <i>et al</i>. \"Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer\". <i>The New England Journal of Medicine</i>. 2012. 367(19):1783-1791.",
             "citation" : "Nogueira RG, <i>et al</i>. \"Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct\". <i>The New England Journal of Medicine</i>. 2018. 378(1):11-21.",
             "subspecialties" : "Oncology",
             "subspecialties" : "Neurology",
             "expansion" : "Emtansine vs. Capecitabine+Lapatinib in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer",
             "expansion" : "DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo",
             "statusUsableDate" : "2013-04-01",
             "statusUsableDate" : "2020-01-23",
             "briefResultsDescription" : "T-DM1 prolongs PFS in metastatic breast cancer",
             "briefResultsDescription" : "Thrombectomy improved 90-day outcomes compared to standard care",
             "published" : "2012-11-08",
             "published" : "2018-01-04",
             "pageName" : "EMILIA",
             "pageName" : "DAWN",
             "diseases" : "Breast Cancer",
             "diseases" : "Stroke",
             "abbreviation" : "EMILIA",
             "abbreviation" : "DAWN",
             "title" : "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer",
             "title" : "Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct",
             "pmid" : "23020162"
             "pmid" : "29129157"
         },
         },
         {
         {
             "timestamp" : "2023-12-14T18:27:14Z",
             "timestamp" : "2012-09-16T11:23:12Z",
             "briefDesignDescription" : "Empagliflozin for CV outcomes in T2DM",
             "briefDesignDescription" : "Intensive glycemic therapy in T1DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1504720",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309303291401",
             "pageid" : 2448,
             "pageid" : 135,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1504720",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309303291401",
             "trainingLevel" : "intern",
             "trainingLevel" : "Student",
             "citation" : "Zinman B, <i>et al</i>. \"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2015. 373(22):2117-28.",
             "citation" : "DCCT Research Group. \"The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus\". <i>The New England Journal of Medicine</i>. 1993. 329(14):977-986.",
             "subspecialties" : "Cardiology;Endocrinology",
             "subspecialties" : "Endocrinology",
             "expansion" : "",
             "expansion" : "Diabetes Control and Complications Trial",
             "statusUsableDate" : "2015-10-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Empagliflozin reduces mortality compared to placebo in patients with type 2 diabetes",
             "briefResultsDescription" : "Intensive therapy delays microvascular but not macrovascular complications in T1DM",
             "published" : "2015-09-17",
             "published" : "1993-09-30",
             "pageName" : "EMPA-REG OUTCOME",
             "pageName" : "DCCT",
             "diseases" : "Diabetes Mellitus",
             "diseases" : "Diabetes Mellitus",
             "abbreviation" : "EMPA-REG OUTCOME",
             "abbreviation" : "DCCT",
             "title" : "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",
             "title" : "The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus",
             "pmid" : "26378978"
             "pmid" : "8366922"
         },
         },
         {
         {
             "timestamp" : "2022-10-13T18:59:03Z",
             "timestamp" : "2014-06-13T04:45:33Z",
             "briefDesignDescription" : "Empagliflozin in HFmrEF and HFpEF",
             "briefDesignDescription" : "ICD vs. medical therapy in HFrEF",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2107038",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa033088",
             "pageid" : 4440,
             "pageid" : 84,
             "pdfurl" : null,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa033088",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Anker S, <i>et al</i>. \"Empagliflozin in Heart Failure with a Preserved Ejection Fraction\". <i>New England Journal of Medicine</i>. 2021. epub 2021-08-27:1-11.",
             "citation" : "Kadish A, <i>et al</i>. \"Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy\". <i>The New England Journal of Medicine</i>. 2004. 350(21):2151-2158.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction",
             "expansion" : "Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation",
             "statusUsableDate" : "2021-09-09",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Empagliflozin improved outcomes in HFpEF",
             "briefResultsDescription" : "ICD reduced risk of arrhythmogenic sudden death, but not overall mortality",
             "published" : "2021-08-27",
             "published" : "2004-05-20",
             "pageName" : "EMPEROR-Preserved",
             "pageName" : "DEFINITE",
             "diseases" : "Heart Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "EMPEROR-Preserved",
             "abbreviation" : "DEFINITE",
             "title" : "Empagliflozin in Heart Failure with a Preserved Ejection Fraction",
             "title" : "Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy",
             "pmid" : "34449189"
             "pmid" : "15152060"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:16Z",
             "timestamp" : "2021-10-04T20:25:15Z",
             "briefDesignDescription" : "Eplerenone in HFrEF",
             "briefDesignDescription" : "Ramelteon vs. placebo to prevent delirium",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009492",
             "fulltexturl" : "http://jamanetwork.com/journals/jamapsychiatry/fullarticle/1831407",
             "pageid" : 120,
             "pageid" : 2806,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009492",
             "pdfurl" : "",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Zannad F, <i>et al</i>. \"Eplerenone in patients with systolic heart failure and mild symptoms\". <i>The New England Journal of Medicine</i>. 2011. 364(1):11-21.",
             "citation" : "Hatta K, <i>et al</i>. \"Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial\". <i>JAMA Psychiatry</i>. 2014. 71(4):397-403.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Psychiatry;Geriatrics",
             "expansion" : "Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure",
             "expansion" : "Delirium Intervention Research for Improving Acute phase outcomes in Japan",
             "statusUsableDate" : "2012-08-01",
             "statusUsableDate" : "2021-09-30",
             "briefResultsDescription" : "Eplerenone reduces CV deaths and HF hospitalizations",
             "briefResultsDescription" : "Ramelteon decreased risk of delirium in elderly patients",
             "published" : "2011-01-06",
             "published" : "2014-04-01",
             "pageName" : "EMPHASIS-HF",
             "pageName" : "DELIRIA-J",
             "diseases" : "Heart Failure",
             "diseases" : "Delirium",
             "abbreviation" : "EMPHASIS-HF",
             "abbreviation" : "DELIRIA-J",
             "title" : "Eplerenone in patients with systolic heart failure and mild symptoms",
             "title" : "Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial",
             "pmid" : "21073363"
             "pmid" : "24554232"
         },
         },
         {
         {
             "timestamp" : "2024-10-03T18:39:58Z",
             "timestamp" : "2023-05-04T03:39:40Z",
             "briefDesignDescription" : "Edoxaban vs. warfarin in AF",
             "briefDesignDescription" : "Dapagliflozin in HFmrEF or HFpEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310907",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2206286",
             "pageid" : 2471,
             "pageid" : 4921,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310907",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2206286",
             "trainingLevel" : "resident",
             "trainingLevel" : "Resident",
             "citation" : "Guigliano RP, <i>et al</i>. \"Edoxaban versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2013. 369(22):2093-2104.",
             "citation" : "Solomon SD, <i>et al</i>. \"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction\". <i>The New England Journal of Medicine</i>. 2022. 387(12):1089-1098.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48",
             "expansion" : "Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure",
             "statusUsableDate" : "2017-02-01",
             "statusUsableDate" : "2022-10-13",
             "briefResultsDescription" : "Edoxaban  is noninferior to warfarin to prevent stroke or thromboembolism",
             "briefResultsDescription" : "Dapagliflozin reduces HF events in HFmrEF or HFpEF",
             "published" : "2013-11-28",
             "published" : "2022-09-22",
             "pageName" : "ENGAGE AF-TIMI 48",
             "pageName" : "DELIVER",
             "diseases" : "Atrial Fibrillation",
             "diseases" : "Heart Failure",
             "abbreviation" : "ENGAGE AF-TIMI 48",
             "abbreviation" : "DELIVER",
             "title" : "Edoxaban versus warfarin in patients with atrial fibrillation",
             "title" : "Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction",
             "pmid" : "24251359"
             "pmid" : "36027570"
         },
         },
         {
         {
             "timestamp" : "2019-04-18T17:47:16Z",
             "timestamp" : "2018-02-01T20:15:39Z",
             "briefDesignDescription" : "Aspirin vs. rivaroxaban for postoperative VTE prophylaxis",
             "briefDesignDescription" : "Oxygen for suspected MI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1712746",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1706222",
             "pageid" : 3552,
             "pageid" : 2970,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1712746",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1706222",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Anderson DR, <i>et al</i>. \"Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty\". <i>The New England Journal of Medicine</i>. 2018. 378(8):699-707.",
             "citation" : "Hofmann R, <i>et al</i>. \"Oxygen therapy in suspected acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 2017. 377(13):1240-1249.",
             "subspecialties" : "Orthopedics;Hematology",
             "subspecialties" : "Cardiology",
             "expansion" : "Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II",
             "expansion" : "Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction",
             "statusUsableDate" : "2018-03-29",
             "statusUsableDate" : "2017-10-01",
             "briefResultsDescription" : "Aspirin similar to rivaroxaban for prevention of VTE",
             "briefResultsDescription" : "Oxygen doesn't improve 1 year survival in MI",
             "published" : "2018-02-22",
             "published" : "2017-09-28",
             "pageName" : "EPCAT II",
             "pageName" : "DETO2X-AMI",
             "diseases" : "Deep Vein Thrombosis;Hip Fracture;Meniscal Tear;Osteoarthritis;Pulmonary Embolism;Venous Thromboembolism",
             "diseases" : "Myocardial Infarction",
             "abbreviation" : "EPCAT II",
             "abbreviation" : "DETO2X-AMI",
             "title" : "Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty",
             "title" : "Oxygen therapy in suspected acute myocardial infarction",
             "pmid" : "29466159"
             "pmid" : "28844200"
         },
         },
         {
         {
             "timestamp" : "2015-12-24T15:08:03Z",
             "timestamp" : "2014-06-13T04:50:56Z",
             "briefDesignDescription" : "Eplerenone post-MI with HFrEF",
             "briefDesignDescription" : "Digoxin in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030207",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199702203360801",
             "pageid" : 16,
             "pageid" : 89,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030207",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199702203360801",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Pitt B, <i>et al</i>. \"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction\". <i>The New England Journal of Medicine</i>. 2003. 348(14):1309-21.",
             "citation" : "Gorlin R, <i>et al</i>. \"The effect of digoxin on mortality and morbidity in patients with heart failure\". <i>The New England Journal of Medicine</i>. 1997. 336(8):525-533.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study",
             "expansion" : "Digitalis Investigation Group",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Mortality benefit of eplerenone post MI with HFrEF",
             "briefResultsDescription" : "Reduced hospitalizations, no mortality benefit",
             "published" : "2003-04-03",
             "published" : "1997-02-20",
             "pageName" : "EPHESUS",
             "pageName" : "DIG",
             "diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
             "diseases" : "Heart Failure",
             "abbreviation" : "EPHESUS",
             "abbreviation" : "DIG",
             "title" : "Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction",
             "title" : "The effect of digoxin on mortality and morbidity in patients with heart failure",
             "pmid" : "12668699"
             "pmid" : "9036306"
         },
         },
         {
         {
             "timestamp" : "2024-10-03T19:17:59Z",
             "timestamp" : "2020-09-14T19:26:41Z",
             "briefDesignDescription" : "Edoxaban±antiplatelet in AF+stable CAD",
             "briefDesignDescription" : "ICD for ICM shortly after MI",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2407362",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa041489",
             "pageid" : 5576,
             "pageid" : 1743,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2407362",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa041489",
             "trainingLevel" : "resident",
             "trainingLevel" : "Resident",
             "citation" : "Choo MS, <i>et al</i>. \"Edoxaban antithrombotic therapy for atrial fibrillation and stable coronary artery disease\". <i>The New England Journal of Medicine</i>. 2024. 1-13.",
             "citation" : "Hohnloser SH, <i>et al</i>. \"Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 2004. 351(24):2481-2488.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease",
             "expansion" : "Defibrillator in Acute Myocardial Infarction Trial",
             "statusUsableDate" : "2024-09-29",
             "statusUsableDate" : "2016-04-01",
             "briefResultsDescription" : "Edoxaban monotherapy has lower bleeding events in AF+stable CAD",
             "briefResultsDescription" : "ICD reduces arrhythmia but not mortality",
             "published" : "2024-09-01",
             "published" : "2004-12-09",
             "pageName" : "EPIC-CAD",
             "pageName" : "DINAMIT",
             "diseases" : "Coronary Artery Disease;Atrial Fibrillation",
             "diseases" : "Heart Failure;Myocardial Infarction",
             "abbreviation" : "EPIC-CAD",
             "abbreviation" : "DINAMIT",
             "title" : "Edoxaban antithrombotic therapy for atrial fibrillation and stable coronary artery disease",
             "title" : "Prophylactic use of an implantable cardioverter–defibrillator after acute myocardial infarction",
             "pmid" : "39225258"
             "pmid" : "15590950"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:20Z",
             "timestamp" : "2019-10-17T17:40:21Z",
             "briefDesignDescription" : "PSA for prostate cancer screening",
             "briefDesignDescription" : "BMS vs. DES for saphenous vein graft PCI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810084",
             "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30801-8/fulltext",
             "pageid" : 2796,
             "pageid" : 3743,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810084",
             "pdfurl" : "",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Schröder FH, <i>et al</i>. \"Screening and Prostate-Cancer Mortality in a Randomized European Study\". <i>The New England Journal of Medicine</i>. 2009. 360(13):1320-1328.",
             "citation" : "Brilakis ES, <i>et al</i>. \"Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial\". <i>Lancet</i>. 2018. 391(10134):1997-2007.",
             "subspecialties" : "Urology;Oncology;Preventive Medicine",
             "subspecialties" : "Cardiology",
             "expansion" : "European Randomized Study of Screening for Prostate Cancer",
             "expansion" : "Rationale and design of the drug-eluting stents vs bare-metal stents in saphenous vein graft angioplasty",
             "statusUsableDate" : "2016-07-01",
             "statusUsableDate" : "2018-11-27",
             "briefResultsDescription" : "Decrease in prostate cancer mortality but increased risk of overdiagnosis and overtreatment",
             "briefResultsDescription" : "BMS noninferior to DES for saphenous vein graft PCI",
             "published" : "2009-07-09",
             "published" : "2018-05-19",
             "pageName" : "ERSPC",
             "pageName" : "DIVA",
             "diseases" : "Prostate Cancer",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "ERSPC",
             "abbreviation" : "DIVA",
             "title" : "Screening and Prostate-Cancer Mortality in a Randomized European Study",
             "title" : "Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial",
             "pmid" : "19297566"
             "pmid" : "29759512"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:21Z",
             "timestamp" : "2019-07-18T20:41:06Z",
             "briefDesignDescription" : "PA catheters in acute HF management",
             "briefDesignDescription" : "D-dimer based anticoagulation discontinuation",
             "fulltexturl" : null,
             "fulltexturl" : "https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14458",
             "pageid" : 1407,
             "pageid" : 4089,
             "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4994/JOC50108.pdf",
             "pdfurl" : "https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14458",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Fellow",
             "citation" : "Binanay C, <i>et al</i>. \"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness\". <i>JAMA</i>. 2005. 294(13):1625-1633.",
             "citation" : "Kearon C, <i>et al</i>. \"Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study\". <i>Journal of Thrombosis and Hemostasis</i>. 2019. 17(7):1144-52.",
             "subspecialties" : "Cardiology;Critical Care",
             "subspecialties" : "Hematology",
             "expansion" : "Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness",
             "expansion" : "D-dimer Optimal Duration Study",
             "statusUsableDate" : "2013-06-01",
             "statusUsableDate" : "2019-07-18",
             "briefResultsDescription" : "Routine PA catheters no better than clinical assessment",
             "briefResultsDescription" : "D-dimer based discontinuation effective in women, not for men",
             "published" : "2005-10-05",
             "published" : "2019-01-18",
             "pageName" : "ESCAPE",
             "pageName" : "DODS",
             "diseases" : "Heart Failure",
             "diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
             "abbreviation" : "ESCAPE",
             "abbreviation" : "DODS",
             "title" : "Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness",
             "title" : "Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results: a cohort study",
             "pmid" : "16204662"
             "pmid" : "31033194"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:22Z",
             "timestamp" : "2019-05-23T17:58:08Z",
             "briefDesignDescription" : "ASA+dipyridamole in secondary stroke prevention",
             "briefDesignDescription" : "Donor HCV positive heart and lung transplant",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2806%2968734-5/fulltext",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1812406",
             "pageid" : 1726,
             "pageid" : 4066,
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606687345.pdf",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812406",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Halkes PH, <i>et al</i>. \"Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial\". <i>The Lancet</i>. 2006. 367(9523):1665-1673.",
             "citation" : "Woolley AE, <i>et al</i>. \"Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients\". <i>The New England Journal of Medicine</i>. 2019. 380(17):1606-1617.",
             "subspecialties" : "Neurology",
             "subspecialties" : "Cardiology",
             "expansion" : "European/Australasian Stroke Prevention in Reversible Ischaemia Trial",
             "expansion" : "Donors of Hepatitis C NAT Positive Thoracic Allografts for Transplantation Evaluation in Non-HCV Recipients",
             "statusUsableDate" : "2013-11-01",
             "statusUsableDate" : "2019-05-17",
             "briefResultsDescription" : "ASA+dipyridamole better than ASA for secondary stroke prevention",
             "briefResultsDescription" : "Donor HCV+ heart & lung transplant is feasible",
             "published" : "2006-05-20",
             "published" : "2019-04-25",
             "pageName" : "ESPRIT",
             "pageName" : "DONATE-HCV",
             "diseases" : "Stroke;Transient Ischemic Attack",
             "diseases" : "Heart Failure;Respiratory Failure",
             "abbreviation" : "ESPRIT",
             "abbreviation" : "DONATE HCV",
             "title" : "Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial",
             "title" : "Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients",
             "pmid" : "16714187"
             "pmid" : "30946553"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:24Z",
             "timestamp" : "2022-09-15T20:00:28Z",
             "briefDesignDescription" : "LMWH vs. UFH in UA/NSTEMI",
             "briefDesignDescription" : "Diuretic dosing in acute HF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199708143370702",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1005419",
             "pageid" : 1443,
             "pageid" : 1457,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199708143370702",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1005419",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Cohen M, <i>et al</i>. \"A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease\". <i>The New England Journal of Medicine</i>. 1997. 337(7):447-452.",
             "citation" : "Felker GM, <i>et al</i>. \"Diuretic strategies in patients with acute decompensated heart failure\". <i>The New England Journal of Medicine</i>. 2011. 364(9):797-805.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group",
             "expansion" : "Diuretic Optimization Strategies Evaluation",
             "statusUsableDate" : "2013-05-01",
             "statusUsableDate" : "2013-06-01",
             "briefResultsDescription" : "LMWH reduces 14-day mortality, MI, or recurrent angina in UA/NSTEMI",
             "briefResultsDescription" : "High-dose better than low-dose, continuous infusions no better than intermittent IV boluses",
             "published" : "1997-08-14",
             "published" : "2011-03-03",
             "pageName" : "ESSENCE",
             "pageName" : "DOSE",
             "diseases" : "Acute Coronary Syndrome",
             "diseases" : "Heart Failure",
             "abbreviation" : "ESSENCE",
             "abbreviation" : "DOSE",
             "title" : "A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease",
             "title" : "Diuretic strategies in patients with acute decompensated heart failure",
             "pmid" : "9250846"
             "pmid" : "21366472"
         },
         },
         {
         {
             "timestamp" : "2021-01-25T01:47:56Z",
             "timestamp" : "2018-05-31T18:34:46Z",
             "briefDesignDescription" : "Ticagrelor vs. clopidogrel in symptomatic PAD",
             "briefDesignDescription" : "Metformin and intensive lifestyle in prediabetes",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611688",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa012512",
             "pageid" : 2878,
             "pageid" : 2494,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611688",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa012512",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Hiatt WR <i>et al</i>. \"Ticagrelor versus clopidogrel in symptomatic peripheral artery disease\". <i>New Engl J Med</i>. 2017. 376(1):32-40.",
             "citation" : "Knowler WC, <i>et al</i>. \"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin\". <i>The New England Journal of Medicine</i>. 2002. 346(6):393-403.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Examining use of ticagrelor in peripheral artery disease",
             "expansion" : "Diabetes Prevention Program",
             "statusUsableDate" : "2017-01-01",
             "statusUsableDate" : "2018-05-31",
             "briefResultsDescription" : "Ticagrelor not superior to clopidogrel in symptomatic PAD",
             "briefResultsDescription" : "Metformin and intensive lifestyle reduce incidence of diabetes",
             "published" : "2017-01-05",
             "published" : "2002-02-07",
             "pageName" : "EUCLID (Ticagrelor)",
             "pageName" : "DPP",
             "diseases" : "Peripheral Vascular Disease",
             "diseases" : "Prediabetes;Diabetes Mellitus",
             "abbreviation" : "EUCLID",
             "abbreviation" : "DPP",
             "title" : "Ticagrelor versus clopidogrel in symptomatic peripheral artery disease",
             "title" : "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin",
             "pmid" : "27959717"
             "pmid" : "11832527"
         },
         },
         {
         {
             "timestamp" : "2018-02-08T17:32:01Z",
             "timestamp" : "2017-12-03T22:35:03Z",
             "briefDesignDescription" : "Perindopril in patients with stable CAD",
             "briefDesignDescription" : "Duct tape vs. cryotherapy for warts",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14286-9/fulltext",
             "fulltexturl" : "",
             "pageid" : 2823,
             "pageid" : 1579,
             "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14286-9.pdf",
             "pdfurl" : "http://archpedi.jamanetwork.com/data/Journals/PEDS/5052/POA20075.pdf",
             "trainingLevel" : "intern",
             "trainingLevel" : "Student",
             "citation" : "Fox KM, <i>et al</i>. \"Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease\". <i>The Lancet</i>. 2003. 362(9386):782–788.",
             "citation" : "Focht DR, <i>et al</i>. \"The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)\". <i>Archives of Pediatric and Adolescent Medicine</i>. 2002. 156:971-974.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Pediatrics;Dermatology",
             "expansion" : "European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease",
             "expansion" : "",
             "statusUsableDate" : "2018-02-08",
             "statusUsableDate" : "2013-07-01",
             "briefResultsDescription" : "Perindopril reduces composite of CV mortality, MI, or cardiac arrest",
             "briefResultsDescription" : "Duct tape superior to cryotherapy for wart resolution",
             "published" : "2003-09-06",
             "published" : "2002-10-01",
             "pageName" : "EUROPA",
             "pageName" : "Duct Tape for Treatment of the Common Wart",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Warts",
             "abbreviation" : "EUROPA",
             "abbreviation" : "",
             "title" : "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease",
             "title" : "The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart)",
             "pmid" : "13678872"
             "pmid" : "12361440"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:34Z",
             "timestamp" : "2018-03-29T18:30:43Z",
             "briefDesignDescription" : "Dexamethasone in meningitis",
             "briefDesignDescription" : "Fecal transplant in C. difficile",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021334",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205037",
             "pageid" : 306,
             "pageid" : 1226,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021334",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205037",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "de Gans JD, <i>et al</i>. \"Dexamethasone in Adults with Bacterial Meningitis\". <i>The New England Journal of Medicine</i>. 2002. 347(20):1549-1556.",
             "citation" : "Van Nood E, <i>et al</i>. \"Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile\". <i>The New England Journal of Medicine</i>. 2013. 368(5):407-415.",
             "subspecialties" : "Infectious Disease;Neurology",
             "subspecialties" : "Gastroenterology;Infectious Disease",
             "expansion" : "European Dexamethasone Study",
             "expansion" : "",
             "statusUsableDate" : "2012-04-01",
             "statusUsableDate" : "2013-02-01",
             "briefResultsDescription" : "Dexamethasone reduces mortality in bacterial meningitis",
             "briefResultsDescription" : "Fecal transplant better than vancomycin in C. difficile",
             "published" : "2002-11-14",
             "published" : "2013-01-31",
             "pageName" : "European Dexamethasone Study",
             "pageName" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
             "diseases" : "Meningitis",
             "diseases" : "Clostridium difficile",
             "abbreviation" : "EDS",
             "abbreviation" : "",
             "title" : "Dexamethasone in Adults with Bacterial Meningitis",
             "title" : "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile",
             "pmid" : "12432041"
             "pmid" : "23323867"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:27Z",
             "timestamp" : "2017-12-03T22:35:32Z",
             "briefDesignDescription" : "Tolvaptan in acute HF in HFrEF",
             "briefDesignDescription" : "Palliative care in NSCLC",
             "fulltexturl" : null,
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000678",
             "pageid" : 1345,
             "pageid" : 466,
             "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5131/joc70029_1319_1331.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000678",
            "trainingLevel" : "Intern",
            "citation" : "Temel JS, <i>et al</i>. \"Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer\". <i>The New England Journal of Medicine</i>. 2010. 363(8):733-742.",
            "subspecialties" : "Oncology;Palliative Care",
            "expansion" : null,
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "Palliative care ↑mood, ↑QOL, ↑survival, ↓aggressive care",
            "published" : "2010-08-19",
            "pageName" : "Early Palliative Care",
            "diseases" : "Lung Cancer",
            "abbreviation" : null,
            "title" : "Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer",
            "pmid" : "20818875"
        },
        {
            "timestamp" : "2018-08-30T17:24:07Z",
            "briefDesignDescription" : "Early TIPS in high-risk cirrhotic variceal bleeding",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910102",
            "pageid" : 2661,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910102",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Konstam MA, <i>et al</i>. \"The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure\". <i>The Journal of the American Medical Association</i>. 2007. 297(12):1319-1331.",
             "citation" : "García-Pagán JC, <i>et al</i>. \"Early use of TIPS in patients with cirrhosis and variceal bleeding\". <i>The New England Journal of Medicine</i>. 2010. 362(25):2370-2379.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Gastroenterology;Interventional Radiology",
             "expansion" : "Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan",
             "expansion" : "",
             "statusUsableDate" : "2013-06-01",
             "statusUsableDate" : "2018-08-30",
             "briefResultsDescription" : "No benefit from tolvaptan when given for 60 days after acute HF episode",
             "briefResultsDescription" : "Early TIPS reduces rates of treatment failure and improves 1-year survival",
             "published" : "2007-03-28",
             "published" : "2010-06-24",
             "pageName" : "EVEREST-Outcomes",
             "pageName" : "Early TIPS",
             "diseases" : "Heart Failure",
             "diseases" : "Cirrhosis;Gastrointestinal Hemorrhage",
             "abbreviation" : "EVEREST",
             "abbreviation" : "Early TIPS",
             "title" : "The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure",
             "title" : "Early use of TIPS in patients with cirrhosis and variceal bleeding",
             "pmid" : "17384437"
             "pmid" : "20573925"
         },
         },
         {
         {
             "timestamp" : "2024-06-27T19:03:26Z",
             "timestamp" : "2021-11-08T18:52:31Z",
             "briefDesignDescription" : "TAVR in low-risk patients",
             "briefDesignDescription" : "Cryoablation vs. antiarrhythmics in AF",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1816885",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
             "pageid" : 4061,
             "pageid" : 4406,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1816885",
             "pdfurl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2029980",
             "trainingLevel" : "resident",
             "trainingLevel" : "Resident",
             "citation" : "Popma JJ, <i>et al</i>. \"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients\". <i>The New England Journal of Medicine</i>. 2019. 380(18):1706-1715.",
             "citation" : "Andrade J, <i>et al</i>. \"Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation\". <i>The New England Journal of Medicine</i>. 2021. 384(4):305-315.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Early Aggressive Invasive Intervention for Atrial Fibrillation",
             "statusUsableDate" : "2024-06-27",
             "statusUsableDate" : "2021-10-14",
             "briefResultsDescription" : "TAVR non-inferior to surgery at 24 months in low-risk patients",
             "briefResultsDescription" : "Cryoablation with lower tachyarrhythmia recurrence than antiarrhythmics.",
             "published" : "2019-05-02",
             "published" : "2021-01-28",
             "pageName" : "Evolut Low Risk",
             "pageName" : "EARLY-AF",
             "diseases" : "Aortic Stenosis",
             "diseases" : "Atrial Fibrillation",
             "abbreviation" : "",
             "abbreviation" : "EARLY-AF",
             "title" : "Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients",
             "title" : "Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation",
             "pmid" : "30883053"
             "pmid" : "33197159"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:28Z",
             "timestamp" : "2019-09-19T17:42:49Z",
             "briefDesignDescription" : "Cinacalcet in ESRD",
             "briefDesignDescription" : "Early surgery in endocarditis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205624",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1112843",
             "pageid" : 2426,
             "pageid" : 2939,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205624",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112843",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Chertow GM, <i>et al</i>. \"Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis\". <i>The New England Journal of Medicine</i>. 2012. 367(26):2482-2494.",
             "citation" : "Kang DH, <i>et al</i>. \"Early surgery versus conventional treatment for infective endocarditis\". <i>The New England Journal of Medicine</i>. 2012. 366(26):2466-73.",
             "subspecialties" : "Nephrology",
             "subspecialties" : "Cardiology;Infectious Disease;Surgery",
             "expansion" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
             "expansion" : "Early Surgery versus Conventional Treatment in Infective Endocarditis",
             "statusUsableDate" : "2015-10-01",
             "statusUsableDate" : "2019-09-19",
             "briefResultsDescription" : "Cinecalcet did not reduce CV events in ESRD",
             "briefResultsDescription" : "Early surgery improves outcomes in infective endocarditis",
             "published" : "2012-12-27",
             "published" : "2012-06-28",
             "pageName" : "EVOLVE",
             "pageName" : "EASE",
             "diseases" : "Chronic Kidney Disease;Cardiovascular Disease",
             "diseases" : "Endocarditis",
             "abbreviation" : "EVOLVE",
             "abbreviation" : "EASE",
             "title" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
             "title" : "Early surgery versus conventional treatment for infective endocarditis",
             "pmid" : "23121374"
             "pmid" : "22738096"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:29Z",
             "timestamp" : "2021-02-09T14:57:23Z",
             "briefDesignDescription" : "CABG vs. PCI in left main CAD",
             "briefDesignDescription" : "Early rhythm vs. rate control in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1610227",
             "fulltexturl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
             "pageid" : 2868,
             "pageid" : 4399,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1610227",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2019422",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Stone GW, <i>et al</i>. \"Everolimus-eluting stents or bypass surgery for left main coronary artery disease\". <i>The New England Journal of Medicine</i>. 2016. 375(23):2223-35.",
             "citation" : "Kirchhof P, <i>et al</i>. \"Early rhythm-control therapy in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2020. 383(14):1305-1316.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL)",
             "expansion" : "The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial",
             "statusUsableDate" : "2016-12-01",
             "statusUsableDate" : "2021-01-28",
             "briefResultsDescription" : "PCI noninferior to CABG in left main CAD with low-intermediate anatomic complexity",
             "briefResultsDescription" : "Early rhythm control with fewer CVD events.",
             "published" : "2016-12-08",
             "published" : "2020-10-01",
             "pageName" : "EXCEL",
             "pageName" : "EAST-AFNET 4",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Atrial Fibrillation",
             "abbreviation" : "EXCEL",
             "abbreviation" : "EAST-AFNET 4",
             "title" : "Everolimus-eluting stents or bypass surgery for left main coronary artery disease",
             "title" : "Early rhythm-control therapy in patients with atrial fibrillation",
             "pmid" : "27797291"
             "pmid" : "32865375"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:31Z",
             "timestamp" : "2017-04-20T01:11:46Z",
             "briefDesignDescription" : "Omalizumab in severe allergic asthma",
             "briefDesignDescription" : "Alteplase 3-4.5h after stroke",
             "fulltexturl" : null,
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0804656",
             "pageid" : 1434,
             "pageid" : 115,
             "pdfurl" : "http://annals.org/data/Journals/AIM/20231/0000605-201105030-00002.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0804656",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Intern",
             "citation" : "Hanania NA, <i>et al</i>. \"Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial\". <i>Annals of Internal Medicine</i>. 2011. 154(9):573-582.",
             "citation" : "Hacke W, <i>et al</i>. \"Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke\". <i>The New England Journal of Medicine</i>. 2008. 359(13):1317-1329.",
             "subspecialties" : "Allergy and Immunology;Pulmonology;Pediatrics",
             "subspecialties" : "Neurology",
             "expansion" : "A Study of Omalizumab/Xolair in Subjects With Moderate to Severe Persistent Asthma",
             "expansion" : "European Cooperative Acute Stroke Study III",
             "statusUsableDate" : "2013-10-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Omalizumab reduces asthma exacerbations",
             "briefResultsDescription" : "Alteplase improves neurological outcomes at 3 months",
             "published" : "2011-05-03",
             "published" : "2008-09-25",
             "pageName" : "EXTRA",
             "pageName" : "ECASS III",
             "diseases" : "Asthma",
             "diseases" : "Stroke",
             "abbreviation" : "EXTRA",
             "abbreviation" : "ECASS III",
             "title" : "Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial",
             "title" : "Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke",
             "pmid" : "21536936"
             "pmid" : "18815396"
         },
         },
         {
         {
             "timestamp" : "2015-11-07T23:16:22Z",
             "timestamp" : "2024-06-27T17:56:09Z",
             "briefDesignDescription" : "Fluid management in ARDS",
             "briefDesignDescription" : "Levetiracetam vs. phenytoin in status epilepticus",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa062200",
             "fulltexturl" : "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30724-X/fulltext",
             "pageid" : 24,
             "pageid" : 4086,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa062200",
             "pdfurl" : "https://www.thelancet.com/action/showPdf?pii",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Wiedemann HP, <i>et al</i>. \"Comparison of two fluid-management strategies in acute lung injury\". <i>The New England Journal of Medicine</i>. 2006. 354(24):2564-75.",
             "citation" : "Lyttle MD, <i>et al</i>. \"Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.\". <i>Lancet</i>. 2019. 393(10186):2125-2134.",
             "subspecialties" : "Critical Care",
             "subspecialties" : "Emergency Medicine;Pediatrics;Neurology",
             "expansion" : "Fluids and Catheters Treatment Trial",
             "expansion" : "Emergency treatment with Levetiracetam or Phenytoin in convulsive Status Epilepticus in children",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2024-05-16",
             "briefResultsDescription" : "Mortality benefit of conservative fluid management in ALI/ARDS",
             "briefResultsDescription" : "Levetiracetam is non-inferior to phenytoin",
             "published" : "2006-06-15",
             "published" : "2019-05-25",
             "pageName" : "FACTT",
             "pageName" : "EcLiPSE",
             "diseases" : "Acute Respiratory Distress Syndrome",
             "diseases" : "Status Epilepticus",
             "abbreviation" : "FACTT",
             "abbreviation" : "EcLiPSE",
             "title" : "Comparison of two fluid-management strategies in acute lung injury",
             "title" : "Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.",
             "pmid" : "16714767"
             "pmid" : "31005385"
         },
         },
         {
         {
             "timestamp" : "2019-02-28T18:37:32Z",
             "timestamp" : "2020-08-01T19:26:48Z",
             "briefDesignDescription" : "Parenteral iron in HFrEF with iron deficiency",
             "briefDesignDescription" : "CEA in symptomatic carotid stenosis",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa0908355",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2909292-1",
             "pageid" : 2691,
             "pageid" : 2354,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa0908355",
             "pdfurl" : "",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Anker SD, <i>et al</i>. \"Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency\". <i>The New England Journal of Medicine</i>. 2009. 361(25):2436-48.",
             "citation" : "ECST Writers. \"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)\". <i>The Lancet</i>. 1998. 351(9113):1379-1387.",
             "subspecialties" : "Cardiology;Hematology",
             "subspecialties" : "Surgery;Neurology",
             "expansion" : "IV Iron for Symptoms in Patients with HFrEF and Iron Deficiency",
             "expansion" : "European Carotid Surgery Trial",
             "statusUsableDate" : "2019-03-01",
             "statusUsableDate" : "2015-08-01",
             "briefResultsDescription" : "IV iron improves HFrEF symptoms in patients with HFrEF and iron deficiency",
             "briefResultsDescription" : "CEA improves outcomes in patients with ≥80% symptomatic carotid stenosis",
             "published" : "2009-12-17",
             "published" : "1998-05-09",
             "pageName" : "FAIR-HF",
             "pageName" : "ECST",
             "diseases" : "Heart Failure;Iron Deficiency Anemia",
             "diseases" : "Carotid Stenosis;Stroke",
             "abbreviation" : "FAIR-HF",
             "abbreviation" : "ECST",
             "title" : "Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency",
             "title" : "Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)",
             "pmid" : "19920054"
             "pmid" : "9593407"
         },
         },
         {
         {
             "timestamp" : "2018-01-03T20:13:15Z",
             "timestamp" : "2013-03-12T08:18:42Z",
             "briefDesignDescription" : "FFR-guided PCI in stable CAD",
             "briefDesignDescription" : "Intensive glycemic therapy in T1DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807611",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052187",
             "pageid" : 998,
             "pageid" : 136,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807611",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052187",
             "trainingLevel" : "resident",
             "trainingLevel" : "intern",
             "citation" : "Tonino PAL, <i>et al</i>. \"Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention\". <i>The New England Journal of Medicine</i>. 2009. 360(3):213-224.",
             "citation" : "Nathan DM, <i>et al</i>. \"Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes\". <i>The New England Journal of Medicine</i>. 2005. 353(25):2643-2653.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Endocrinology",
             "expansion" : "Fractional Flow Reserve versus Angiography for Multivessel Evaluation",
             "expansion" : "Epidemiology of Diabetes Interventions and Complications",
             "statusUsableDate" : "2012-10-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "FFR reduces composite of death, nonfatal MI, urgent revascularization",
             "briefResultsDescription" : "Intensive therapy associated with fewer cardiovascular complications",
             "published" : "2009-01-15",
             "published" : "2005-12-22",
             "pageName" : "FAME",
             "pageName" : "EDIC",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Diabetes Mellitus",
             "abbreviation" : "FAME",
             "abbreviation" : "EDIC",
             "title" : "Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention",
             "title" : "Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes",
             "pmid" : "19144937"
             "pmid" : "16371630"
         },
         },
         {
         {
             "timestamp" : "2018-07-05T13:05:28Z",
             "timestamp" : "2017-12-03T22:35:08Z",
             "briefDesignDescription" : "FFR-guided PCI vs. OMT in CAD",
             "briefDesignDescription" : "Rivaroxaban after VTE treatment",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205361",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1700518",
             "pageid" : 1003,
             "pageid" : 2927,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205361",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1700518",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "De Bruyne B, <i>et al</i>. \"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease\". <i>The New England Journal of Medicine</i>. 2012. 367(11):991-1001.",
             "citation" : "Weitz JI, <i>et al</i>. \"Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2017. 376(13):1211-22.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Hematology",
             "expansion" : "FFR vs. Angiographyfor Multivessel Evaluation 2",
             "expansion" : "Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic Venous Thromboembolism",
             "statusUsableDate" : "2012-11-01",
             "statusUsableDate" : "2017-07-01",
             "briefResultsDescription" : "FFR-guided PCI reduces urgent revascularization",
             "briefResultsDescription" : "Rivaroxaban reduces recurrent VTE",
             "published" : "2012-09-13",
             "published" : "2017-03-30",
             "pageName" : "FAME 2",
             "pageName" : "EINSTEIN CHOICE",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Venous Thromboembolism;Deep Vein Thrombosis;Pulmonary Embolism",
             "abbreviation" : "FAME 2",
             "abbreviation" : "EINSTEIN CHOICE",
             "title" : "Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease",
             "title" : "Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism",
             "pmid" : "22924638"
             "pmid" : "28316279"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:38Z",
             "timestamp" : "2017-12-03T22:35:09Z",
             "briefDesignDescription" : "Fluid resuscitation in Sub-Saharan Africa",
             "briefDesignDescription" : "Rivaroxaban vs. warfarin in PE",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1101549",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1113572",
             "pageid" : 1860,
             "pageid" : 1519,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1101549",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1113572",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Maitland K, <i>et al</i>. \"Mortality after fluid bolus in African children with severe infection\". <i>The New England Journal of Medicine</i>. 2011. 364(26):2483-2495.",
             "citation" : "Büller HR, <i>et al</i>. \"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism\". <i>The New England Journal of Medicine</i>. 2012. 366(14):1287-1297.",
             "subspecialties" : "Pediatrics;Critical Care",
             "subspecialties" : "Hematology;Pulmonology",
             "expansion" : "Fluid Expansion as Supportive Therapy",
             "expansion" : "",
             "statusUsableDate" : "2014-11-01",
             "statusUsableDate" : "2013-07-01",
             "briefResultsDescription" : "Albumin and saline increase mortality when compared to no fluids in this patient population",
             "briefResultsDescription" : "Rivaroxaban is noninferior to warfarin in PE treatment",
             "published" : "2011-06-30",
             "published" : "2012-04-05",
             "pageName" : "FEAST",
             "pageName" : "EINSTEIN-PE",
             "diseases" : "Shock",
             "diseases" : "Pulmonary Embolism;Venous Thromboembolism",
             "abbreviation" : "FEAST",
             "abbreviation" : "EINSTEIN-PE",
             "title" : "Mortality after fluid bolus in African children with severe infection",
             "title" : "Oral rivaroxaban for the treatment of symptomatic pulmonary embolism",
             "pmid" : "21615299"
             "pmid" : "22449293"
         },
         },
         {
         {
             "timestamp" : "2013-10-07T20:50:13Z",
             "timestamp" : "2018-05-27T16:17:38Z",
             "briefDesignDescription" : "Fidaxomicin in C. difficile",
             "briefDesignDescription" : "Immunosuppression after kidney transplant",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910812",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa067411",
             "pageid" : 255,
             "pageid" : 2324,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910812",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa067411",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Louie TJ, <i>et al</i>. \"Fidaxomicin versus Vancomycin for Clostridium difficile Infection\". <i>The New England Journal of Medicine</i>. 2011. 365(5):422-431.",
             "citation" : "Ekberg H, <i>et al</i>. \"Reduced exposure to calcineurin inhibitors in renal transplantation\". <i>The New England Journal of Medicine</i>. 2007. 357(25):2562-2575.",
             "subspecialties" : "Infectious Disease;Gastroenterology",
             "subspecialties" : "Nephrology",
             "expansion" : null,
             "expansion" : "Efficacy Limiting Toxicity Elimination-Symphony",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2015-02-01",
             "briefResultsDescription" : "Fidaxomicin noninferior to vancomycin for cure, and resulted in 45% fewer recurrences",
             "briefResultsDescription" : "Daclizumab, mycophenolate, steroids, and tacrolimus beneficial",
             "published" : "2011-02-03",
             "published" : "2007-12-20",
             "pageName" : "Fidaxomicin in C. difficile Diarrhea",
             "pageName" : "ELITE-Symphony",
             "diseases" : "Clostridium difficile",
             "diseases" : "Kidney Transplant",
             "abbreviation" : null,
             "abbreviation" : "ELITE-Symphony",
             "title" : "Fidaxomicin versus Vancomycin for Clostridium difficile Infection",
             "title" : "Reduced exposure to calcineurin inhibitors in renal transplantation",
             "pmid" : "21288078"
             "pmid" : "18094377"
         },
         },
         {
         {
             "timestamp" : "2024-10-17T17:57:15Z",
             "timestamp" : "2018-09-13T17:28:08Z",
             "briefDesignDescription" : "Mineralocorticoid antagonist in CKD/T2DM",
             "briefDesignDescription" : "Extended EKG monitoring after cryptogenic stroke",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2025845",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1311376",
             "pageid" : 4384,
             "pageid" : 2403,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2025845",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1311376",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Bakris GL, <i>et al</i>. \"Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2020. 383(23):2219-2229.",
             "citation" : "Gladstone DJ, <i>et al</i>. \"Atrial Fibrillation in Patients with Cryptogenic Stroke\". <i>The New England Journal of Medicine</i>. 2014. 370(26):2467-2477.",
             "subspecialties" : "Nephrology;Endocrinology",
             "subspecialties" : "Neurology;Cardiology",
             "expansion" : "Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease",
             "expansion" : "30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation after a Cerebral Ischemic Event",
             "statusUsableDate" : "2024-10-17",
             "statusUsableDate" : "2018-09-13",
             "briefResultsDescription" : "Mineralocorticoid antagonist slows CKD progression",
             "briefResultsDescription" : "Extended EKG monitoring detects AF more frequently than 24-hour monitoring",
             "published" : "2020-10-23",
             "published" : "2014-06-26",
             "pageName" : "FIDELIO-DKD",
             "pageName" : "EMBRACE",
             "diseases" : "Chronic Kidney Disease;Diabetes Mellitus",
             "diseases" : "Stroke;Atrial Fibrillation",
             "abbreviation" : "FIDELIO-DKD",
             "abbreviation" : "EMBRACE",
             "title" : "Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes",
             "title" : "Atrial Fibrillation in Patients with Cryptogenic Stroke",
             "pmid" : "33264825"
             "pmid" : "24963566"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:39Z",
             "timestamp" : "2021-07-28T13:09:44Z",
             "briefDesignDescription" : "Cryoablation vs. RF ablation in pAF",
             "briefDesignDescription" : "T-DM1 in metastatic breast cancer",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602014",
             "fulltexturl" : "http://www.nejm.org/doi/abs/10.1056/NEJMoa1209124",
             "pageid" : 2795,
             "pageid" : 1257,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602014",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1209124",
             "trainingLevel" : "Resident",
             "trainingLevel" : "fellow",
             "citation" : "Kuck K, <i>et al</i>. \"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2016. 374(23):2235-45.",
             "citation" : "Verma S, <i>et al</i>. \"Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer\". <i>The New England Journal of Medicine</i>. 2012. 367(19):1783-1791.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Oncology",
             "expansion" : "",
             "expansion" : "Emtansine vs. Capecitabine+Lapatinib in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer",
             "statusUsableDate" : "2016-07-01",
             "statusUsableDate" : "2013-04-01",
             "briefResultsDescription" : "Cryoablation equivalent to RF ablation in pAF",
             "briefResultsDescription" : "T-DM1 prolongs PFS in metastatic breast cancer",
             "published" : "2016-06-09",
             "published" : "2012-11-08",
             "pageName" : "FIRE AND ICE",
             "pageName" : "EMILIA",
             "diseases" : "Atrial Fibrillation",
             "diseases" : "Breast Cancer",
             "abbreviation" : "FIRE AND ICE",
             "abbreviation" : "EMILIA",
             "title" : "Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation",
             "title" : "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer",
             "pmid" : "27042964"
             "pmid" : "23020162"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:41Z",
             "timestamp" : "2023-12-14T18:27:14Z",
             "briefDesignDescription" : "LABA+LAMA vs. LABA+ICS in COPD",
             "briefDesignDescription" : "Empagliflozin for CV outcomes in T2DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1516385",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1504720",
             "pageid" : 2871,
             "pageid" : 2448,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1516385",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1504720",
             "trainingLevel" : "Resident",
             "trainingLevel" : "intern",
             "citation" : "Wedzicha JA, <i>et al</i>. \"Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD\". <i>The New England Journal of Medicine</i>. 2016. 374(23):2222-2234.",
             "citation" : "Zinman B, <i>et al</i>. \"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes\". <i>The New England Journal of Medicine</i>. 2015. 373(22):2117-28.",
             "subspecialties" : "Pulmonology",
             "subspecialties" : "Cardiology;Endocrinology",
             "expansion" : "Effect of Indacaterol Glycopyronium Vs. Fluticasone Salmeterol on COPD Exacerbations",
             "expansion" : "",
             "statusUsableDate" : "2017-01-01",
             "statusUsableDate" : "2015-10-01",
             "briefResultsDescription" : "LABA+LAMA reduces COPD exacerbations",
             "briefResultsDescription" : "Empagliflozin reduces mortality compared to placebo in patients with type 2 diabetes",
             "published" : "2016-06-09",
             "published" : "2015-09-17",
             "pageName" : "FLAME (COPD)",
             "pageName" : "EMPA-REG OUTCOME",
             "diseases" : "Emphysema;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease",
             "diseases" : "Diabetes Mellitus",
             "abbreviation" : "FLAME COPD",
             "abbreviation" : "EMPA-REG OUTCOME",
             "title" : "Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD",
             "title" : "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",
             "pmid" : "27181606"
             "pmid" : "26378978"
         },
         },
         {
         {
             "timestamp" : "2018-10-08T21:47:35Z",
             "timestamp" : "2022-10-13T18:59:03Z",
             "briefDesignDescription" : "SSRI after CVA for motor recovery",
             "briefDesignDescription" : "Empagliflozin in HFmrEF and HFpEF",
             "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S1474-4422(10)70314-8",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2107038",
             "pageid" : 2370,
             "pageid" : 4440,
             "pdfurl" : "",
             "pdfurl" : null,
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Chollet F, <i>et al</i>. \"Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial\". <i>The Lancet Neurology</i>. 2011. 10(2):123-130.",
             "citation" : "Anker S, <i>et al</i>. \"Empagliflozin in Heart Failure with a Preserved Ejection Fraction\". <i>New England Journal of Medicine</i>. 2021. epub 2021-08-27:1-11.",
             "subspecialties" : "Neurology",
             "subspecialties" : "Cardiology",
             "expansion" : "Fluoxetine for Motor Recovery after Acute Ischaemic Stroke",
             "expansion" : "Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction",
             "statusUsableDate" : "2015-08-01",
             "statusUsableDate" : "2021-09-09",
             "briefResultsDescription" : "Early fluoxetine improved motor outcomes post stroke",
             "briefResultsDescription" : "Empagliflozin improved outcomes in HFpEF",
             "published" : "2011-02-01",
             "published" : "2021-08-27",
             "pageName" : "FLAME (Stroke)",
             "pageName" : "EMPEROR-Preserved",
             "diseases" : "Stroke",
             "diseases" : "Heart Failure",
             "abbreviation" : "FLAME",
             "abbreviation" : "EMPEROR-Preserved",
             "title" : "Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial",
             "title" : "Empagliflozin in Heart Failure with a Preserved Ejection Fraction",
             "pmid" : "21216670"
             "pmid" : "34449189"
         },
         },
         {
         {
             "timestamp" : "2024-10-03T17:48:57Z",
             "timestamp" : "2017-12-03T22:35:16Z",
             "briefDesignDescription" : "High-flow oxygen in respiratory failure",
             "briefDesignDescription" : "Eplerenone in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1503326",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1009492",
             "pageid" : 2375,
             "pageid" : 120,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1503326",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1009492",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Frat JP, <i>et al</i>. \"High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure\". <i>The New England Journal of Medicine</i>. 2015. 372(23):2185-2196.",
             "citation" : "Zannad F, <i>et al</i>. \"Eplerenone in patients with systolic heart failure and mild symptoms\". <i>The New England Journal of Medicine</i>. 2011. 364(1):11-21.",
             "subspecialties" : "Pulmonology;Critical Care Medicine",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2012-08-01",
             "briefResultsDescription" : "High-flow oxygen therapy reduces intubation need",
             "briefResultsDescription" : "Eplerenone reduces CV deaths and HF hospitalizations",
             "published" : "2015-06-04",
             "published" : "2011-01-06",
             "pageName" : "FLORALI",
             "pageName" : "EMPHASIS-HF",
             "diseases" : "Hypoxemic Respiratory Failure",
             "diseases" : "Heart Failure",
             "abbreviation" : "FLORALI",
             "abbreviation" : "EMPHASIS-HF",
             "title" : "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure",
             "title" : "Eplerenone in patients with systolic heart failure and mild symptoms",
             "pmid" : "25981908"
             "pmid" : "21073363"
         },
         },
         {
         {
             "timestamp" : "2017-12-14T18:13:26Z",
             "timestamp" : "2024-10-03T18:39:58Z",
             "briefDesignDescription" : "Transfusion thresholds after hip surgery",
             "briefDesignDescription" : "Edoxaban vs. warfarin in AF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1012452",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1310907",
             "pageid" : 2985,
             "pageid" : 2471,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1012452",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310907",
             "trainingLevel" : "Resident",
             "trainingLevel" : "resident",
             "citation" : "Carson JL, <i>et al</i>. \"Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery\". <i>The New england Journal of Medicine</i>. 2011. 365(26):2453-62.",
             "citation" : "Guigliano RP, <i>et al</i>. \"Edoxaban versus warfarin in patients with atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2013. 369(22):2093-2104.",
             "subspecialties" : "Hematology;Surgery",
             "subspecialties" : "Cardiology",
             "expansion" : "Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair",
             "expansion" : "Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation - Thrombolysis in Myocardial Infarction 48",
             "statusUsableDate" : "2017-12-14",
             "statusUsableDate" : "2017-02-01",
             "briefResultsDescription" : "Liberal transfusions no better than restrictive",
             "briefResultsDescription" : "Edoxaban  is noninferior to warfarin to prevent stroke or thromboembolism",
             "published" : "2011-12-29",
             "published" : "2013-11-28",
             "pageName" : "FOCUS",
             "pageName" : "ENGAGE AF-TIMI 48",
             "diseases" : "Hip Fracture;Anemia",
             "diseases" : "Atrial Fibrillation",
             "abbreviation" : "FOCUS",
             "abbreviation" : "ENGAGE AF-TIMI 48",
             "title" : "Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery",
             "title" : "Edoxaban versus warfarin in patients with atrial fibrillation",
             "pmid" : "22168590"
             "pmid" : "24251359"
         },
         },
         {
         {
             "timestamp" : "2020-11-05T18:42:16Z",
             "timestamp" : "2019-04-18T17:47:16Z",
             "briefDesignDescription" : "Evolocumab for CVD events if atherosclerotic disease",
             "briefDesignDescription" : "Aspirin vs. rivaroxaban for postoperative VTE prophylaxis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1615664",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1712746",
             "pageid" : 2891,
             "pageid" : 3552,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1615664",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1712746",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Sabatine MS, <i>et al</i>. \"Evolocumab and clinical outcomes in patients with cardiovascular disease\". <i>The New England Journal of Medicine</i>. 2017. epub 2017-03-17:1-10.",
             "citation" : "Anderson DR, <i>et al</i>. \"Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty\". <i>The New England Journal of Medicine</i>. 2018. 378(8):699-707.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Orthopedics;Hematology",
             "expansion" : "Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk",
             "expansion" : "Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty II",
             "statusUsableDate" : "2017-03-01",
             "statusUsableDate" : "2018-03-29",
             "briefResultsDescription" : "Evolocumab reduces CV events in patients with atherosclerotic disease",
             "briefResultsDescription" : "Aspirin similar to rivaroxaban for prevention of VTE",
             "published" : "2017-03-17",
             "published" : "2018-02-22",
             "pageName" : "FOURIER",
             "pageName" : "EPCAT II",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Deep Vein Thrombosis;Hip Fracture;Meniscal Tear;Osteoarthritis;Pulmonary Embolism;Venous Thromboembolism",
             "abbreviation" : "FOURIER",
             "abbreviation" : "EPCAT II",
             "title" : "Evolocumab and clinical outcomes in patients with cardiovascular disease",
             "title" : "Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty",
             "pmid" : "28304224"
             "pmid" : "29466159"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:45Z",
             "timestamp" : "2015-12-24T15:08:03Z",
             "briefDesignDescription" : "CABG vs. PCI for CAD in T2DM",
             "briefDesignDescription" : "Eplerenone post-MI with HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211585",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa030207",
             "pageid" : 2314,
             "pageid" : 16,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211585",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa030207",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Farkouh ME, <i>et al</i>. \"Strategies for multivessel revascularization in patients with diabetes\". <i>The New England Journal of Medicine</i>. 2012. 367(25):2375-2384.",
             "citation" : "Pitt B, <i>et al</i>. \"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction\". <i>The New England Journal of Medicine</i>. 2003. 348(14):1309-21.",
             "subspecialties" : "Cardiology;Endocrinology",
             "subspecialties" : "Cardiology",
             "expansion" : "Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease",
             "expansion" : "Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study",
             "statusUsableDate" : "2016-04-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "CABG reduces death and revascularization rates but causes more strokes",
             "briefResultsDescription" : "Mortality benefit of eplerenone post MI with HFrEF",
             "published" : "2012-12-20",
             "published" : "2003-04-03",
             "pageName" : "FREEDOM",
             "pageName" : "EPHESUS",
             "diseases" : "Coronary Artery Disease;Diabetes Mellitus",
             "diseases" : "Heart Failure;Acute Coronary Syndrome;Myocardial Infarction",
             "abbreviation" : "FREEDOM",
             "abbreviation" : "EPHESUS",
             "title" : "Strategies for multivessel revascularization in patients with diabetes",
             "title" : "Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction",
             "pmid" : "23121323"
             "pmid" : "12668699"
         },
         },
         {
         {
             "timestamp" : "2021-06-01T13:47:49Z",
             "timestamp" : "2024-10-03T19:17:59Z",
             "briefDesignDescription" : "Early invasive strategy in UA/NSTEMI",
             "briefDesignDescription" : "Edoxaban±antiplatelet in AF+stable CAD",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07349-3/fulltext",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2407362",
             "pageid" : 2451,
             "pageid" : 5576,
             "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(99)07349-3.pdf",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2407362",
             "trainingLevel" : "Resident",
             "trainingLevel" : "resident",
             "citation" : "FRISC Investigators. \"Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study\". <i>The Lancet</i>. 1999. 354(9180):708-15.",
             "citation" : "Choo MS, <i>et al</i>. \"Edoxaban antithrombotic therapy for atrial fibrillation and stable coronary artery disease\". <i>The New England Journal of Medicine</i>. 2024. 1-13.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "FRagmin and Fast Revascularisation during InStability in Coronary artery disease-II",
             "expansion" : "Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease",
             "statusUsableDate" : "2015-11-01",
             "statusUsableDate" : "2024-09-29",
             "briefResultsDescription" : "Fewer recurrent MIs with early invasive strategy in high-risk patients",
             "briefResultsDescription" : "Edoxaban monotherapy has lower bleeding events in AF+stable CAD",
             "published" : "1999-08-28",
             "published" : "2024-09-01",
             "pageName" : "FRISC-II",
             "pageName" : "EPIC-CAD",
             "diseases" : "Coronary Artery Disease;Myocardial Infarction;Acute Coronary Syndrome",
             "diseases" : "Coronary Artery Disease;Atrial Fibrillation",
             "abbreviation" : "FRISC-II",
             "abbreviation" : "EPIC-CAD",
             "title" : "Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study",
             "title" : "Edoxaban antithrombotic therapy for atrial fibrillation and stable coronary artery disease",
             "pmid" : "10475181"
             "pmid" : "39225258"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:49Z",
             "timestamp" : "2017-12-03T22:35:20Z",
             "briefDesignDescription" : "Risk factors for GI bleeds in ICU patients",
             "briefDesignDescription" : "PSA for prostate cancer screening",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199402103300601",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0810084",
             "pageid" : 391,
             "pageid" : 2796,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199402103300601",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0810084",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Intern",
             "citation" : "Cook DJ, <i>et al</i>. \"Risk factors for gastrointestinal bleeding in critically ill patients\". <i>The New England Journal of Medicine</i>. 1994. 330(6):337-381.",
             "citation" : "Schröder FH, <i>et al</i>. \"Screening and Prostate-Cancer Mortality in a Randomized European Study\". <i>The New England Journal of Medicine</i>. 2009. 360(13):1320-1328.",
             "subspecialties" : "Critical Care;Gastroenterology",
             "subspecialties" : "Urology;Oncology;Preventive Medicine",
             "expansion" : null,
             "expansion" : "European Randomized Study of Screening for Prostate Cancer",
             "statusUsableDate" : "2013-10-01",
             "statusUsableDate" : "2016-07-01",
             "briefResultsDescription" : "Greatest risk for GI bleed with coagulopathy and mechanical ventilation",
             "briefResultsDescription" : "Decrease in prostate cancer mortality but increased risk of overdiagnosis and overtreatment",
             "published" : "1994-02-10",
             "published" : "2009-07-09",
             "pageName" : "GI bleeding in ICU patients",
             "pageName" : "ERSPC",
             "diseases" : "Gastrointestinal Hemorrhage",
             "diseases" : "Prostate Cancer",
             "abbreviation" : null,
             "abbreviation" : "ERSPC",
             "title" : "Risk factors for gastrointestinal bleeding in critically ill patients",
             "title" : "Screening and Prostate-Cancer Mortality in a Randomized European Study",
             "pmid" : "8284001"
             "pmid" : "19297566"
         },
         },
         {
         {
             "timestamp" : "2014-09-24T22:28:37Z",
             "timestamp" : "2017-12-03T22:35:21Z",
             "briefDesignDescription" : "Lisinopril in acute MI",
             "briefDesignDescription" : "PA catheters in acute HF management",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2894%2990232-1/abstract",
             "fulltexturl" : null,
             "pageid" : 258,
             "pageid" : 1407,
             "pdfurl" : "",
             "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/4994/JOC50108.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "GISSI-3 Group. \"Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction\". <i>The Lancet</i>. 1994. 343(8906):1115-22.",
             "citation" : "Binanay C, <i>et al</i>. \"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness\". <i>JAMA</i>. 2005. 294(13):1625-1633.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology;Critical Care",
             "expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico",
             "expansion" : "Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2013-06-01",
             "briefResultsDescription" : "Lisinopril improves 6-week mortality",
             "briefResultsDescription" : "Routine PA catheters no better than clinical assessment",
             "published" : "1994-05-07",
             "published" : "2005-10-05",
             "pageName" : "GISSI-3",
             "pageName" : "ESCAPE",
             "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
             "diseases" : "Heart Failure",
             "abbreviation" : "GISSI-3",
             "abbreviation" : "ESCAPE",
             "title" : "Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction",
             "title" : "Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness",
             "pmid" : "7910229"
             "pmid" : "16204662"
         },
         },
         {
         {
             "timestamp" : "2023-08-03T17:47:16Z",
             "timestamp" : "2017-12-03T22:35:22Z",
             "briefDesignDescription" : "PUFA in patients with heart failure",
             "briefDesignDescription" : "ASA+dipyridamole in secondary stroke prevention",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61239-8/fulltext",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2806%2968734-5/fulltext",
             "pageid" : 2824,
             "pageid" : 1726,
             "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)61239-8.pdf",
             "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673606687345.pdf",
             "trainingLevel" : "intern",
             "trainingLevel" : "Intern",
             "citation" : "Tavazzi L, <i>et al</i>. \"Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure\". <i>The Lancet</i>. 2008. 372(9645):1223-1230.",
             "citation" : "Halkes PH, <i>et al</i>. \"Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial\". <i>The Lancet</i>. 2006. 367(9523):1665-1673.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Neurology",
             "expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione",
             "expansion" : "European/Australasian Stroke Prevention in Reversible Ischaemia Trial",
             "statusUsableDate" : "2023-07-31",
             "statusUsableDate" : "2013-11-01",
             "briefResultsDescription" : "PUFA reduces all-cause mortality and admission for CV disease",
             "briefResultsDescription" : "ASA+dipyridamole better than ASA for secondary stroke prevention",
             "published" : "2008-10-04",
             "published" : "2006-05-20",
             "pageName" : "GISSI-HF",
             "pageName" : "ESPRIT",
             "diseases" : "Heart failure",
             "diseases" : "Stroke;Transient Ischemic Attack",
             "abbreviation" : "GISSI-HF",
             "abbreviation" : "ESPRIT",
             "title" : "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure",
             "title" : "Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomized controlled trial",
             "pmid" : "18757090"
             "pmid" : "16714187"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:51Z",
             "timestamp" : "2017-12-03T22:35:24Z",
             "briefDesignDescription" : "tPA in ACS",
             "briefDesignDescription" : "LMWH vs. UFH in UA/NSTEMI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309023291001",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199708143370702",
             "pageid" : 2177,
             "pageid" : 1443,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309023291001",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199708143370702",
             "trainingLevel" : "Student",
             "trainingLevel" : "Intern",
             "citation" : "Topol E, <i>et al</i>. \"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 1993. 329(10):673-682.",
             "citation" : "Cohen M, <i>et al</i>. \"A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease\". <i>The New England Journal of Medicine</i>. 1997. 337(7):447-452.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries",
             "expansion" : "Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study Group",
             "statusUsableDate" : "2014-09-01",
             "statusUsableDate" : "2013-05-01",
             "briefResultsDescription" : "tPA reduces mortality in ACS",
             "briefResultsDescription" : "LMWH reduces 14-day mortality, MI, or recurrent angina in UA/NSTEMI",
             "published" : "1993-09-03",
             "published" : "1997-08-14",
             "pageName" : "GUSTO",
             "pageName" : "ESSENCE",
             "diseases" : "Myocardial Infarction;Acute Coronary Syndrome",
             "diseases" : "Acute Coronary Syndrome",
             "abbreviation" : "GUSTO",
             "abbreviation" : "ESSENCE",
             "title" : "An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction",
             "title" : "A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease",
             "pmid" : "8204123"
             "pmid" : "9250846"
         },
         },
         {
         {
             "timestamp" : "2024-08-25T20:47:09Z",
             "timestamp" : "2021-01-25T01:47:56Z",
             "briefDesignDescription" : "Hypothermia for cardiac arrest",
             "briefDesignDescription" : "Ticagrelor vs. clopidogrel in symptomatic PAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/nejmoa012689",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1611688",
             "pageid" : 410,
             "pageid" : 2878,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa012689",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1611688",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Holzer M, <i>et al</i>. \"Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest\". <i>The New England Journal of Medicine</i>. 2002. 346(8):549-556.",
             "citation" : "Hiatt WR <i>et al</i>. \"Ticagrelor versus clopidogrel in symptomatic peripheral artery disease\". <i>New Engl J Med</i>. 2017. 376(1):32-40.",
             "subspecialties" : "Critical Care;Neurology;Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Hypothermia After Cardiac Arrest",
             "expansion" : "Examining use of ticagrelor in peripheral artery disease",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2017-01-01",
             "briefResultsDescription" : "Hypothermia improves neurologic outcomes and reduces mortality",
             "briefResultsDescription" : "Ticagrelor not superior to clopidogrel in symptomatic PAD",
             "published" : "2002-02-21",
             "published" : "2017-01-05",
             "pageName" : "HACA",
             "pageName" : "EUCLID (Ticagrelor)",
             "diseases" : "Cardiac Arrest",
             "diseases" : "Peripheral Vascular Disease",
             "abbreviation" : "HACA",
             "abbreviation" : "EUCLID",
             "title" : "Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest",
             "title" : "Ticagrelor versus clopidogrel in symptomatic peripheral artery disease",
             "pmid" : "11856793"
             "pmid" : "27959717"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:53Z",
             "timestamp" : "2018-02-08T17:32:01Z",
             "briefDesignDescription" : "Continuous-flow LVAD in heart failure",
             "briefDesignDescription" : "Perindopril in patients with stable CAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909938#t",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14286-9/fulltext",
             "pageid" : 2808,
             "pageid" : 2823,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909938",
             "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(03)14286-9.pdf",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "intern",
             "citation" : "Slaughter MS, <i>et al</i>. \"Advanced heart failure treated with continuous-flow left ventricular assist device\". <i>The New England Journal of Medicine</i>. 2009. 361(23):2241-2251.",
             "citation" : "Fox KM, <i>et al</i>. \"Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease\". <i>The Lancet</i>. 2003. 362(9386):782–788.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
             "expansion" : "European Trial on Reduction of Cardiac Events with Perindopril in Patients with Stable Coronary Artery Disease",
             "statusUsableDate" : "2016-09-01",
             "statusUsableDate" : "2018-02-08",
             "briefResultsDescription" : "Continuous-flow LVAD improved survival free from stroke and device failure",
             "briefResultsDescription" : "Perindopril reduces composite of CV mortality, MI, or cardiac arrest",
             "published" : "2009-12-03",
             "published" : "2003-09-06",
             "pageName" : "HEARTMATE II",
             "pageName" : "EUROPA",
             "diseases" : "Heart Failure",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "HEARTMATE II",
             "abbreviation" : "EUROPA",
             "title" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
             "title" : "Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease",
             "pmid" : "19920051"
             "pmid" : "13678872"
         },
         },
         {
         {
             "timestamp" : "2020-11-04T18:25:05Z",
             "timestamp" : "2017-12-03T22:35:34Z",
             "briefDesignDescription" : "Acetaminophen in febrile ICU patients",
             "briefDesignDescription" : "Dexamethasone in meningitis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1508375",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021334",
             "pageid" : 2690,
             "pageid" : 306,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1508375",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021334",
            "trainingLevel" : "Intern",
            "citation" : "Young P, <i>et al</i>. \"Acetaminophen for Fever in Critically Ill Patients with Suspected Infection\". <i>The New England Journal of Medicine</i>. 2015. 373(23):2215-2224.",
            "subspecialties" : "Critical Care;Infectious Disease",
            "expansion" : "Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit",
            "statusUsableDate" : "2017-09-01",
            "briefResultsDescription" : "Acetaminophen does not improves ICU outcomes",
            "published" : "2015-12-03",
            "pageName" : "HEAT",
            "diseases" : "Sepsis;Fever",
            "abbreviation" : "HEAT",
            "title" : "Acetaminophen for Fever in Critically Ill Patients with Suspected Infection",
            "pmid" : "26436473"
        },
        {
            "timestamp" : "2023-02-02T19:36:38Z",
            "briefDesignDescription" : "Heparin vs. bivalirudin in PCI",
            "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60924-7",
            "pageid" : 2394,
            "pdfurl" : "",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Shahzad A, <i>et al</i>. \"Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.\". <i>The Lancet</i>. 2014. 384(9957):1849-1858.",
             "citation" : "de Gans JD, <i>et al</i>. \"Dexamethasone in Adults with Bacterial Meningitis\". <i>The New England Journal of Medicine</i>. 2002. 347(20):1549-1556.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Infectious Disease;Neurology",
             "expansion" : "",
             "expansion" : "European Dexamethasone Study",
             "statusUsableDate" : "2023-01-29",
             "statusUsableDate" : "2012-04-01",
             "briefResultsDescription" : "Heparin better than bivalirudin for PCI",
             "briefResultsDescription" : "Dexamethasone reduces mortality in bacterial meningitis",
             "published" : "2014-11-22",
             "published" : "2002-11-14",
             "pageName" : "HEAT-PPCI",
             "pageName" : "European Dexamethasone Study",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Meningitis",
             "abbreviation" : "HEAT-PPCI",
             "abbreviation" : "EDS",
             "title" : "Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.",
             "title" : "Dexamethasone in Adults with Bacterial Meningitis",
             "pmid" : "25002178"
             "pmid" : "12432041"
         },
         },
         {
         {
             "timestamp" : "2018-10-25T17:06:10Z",
             "timestamp" : "2017-12-03T22:35:27Z",
             "briefDesignDescription" : "High dialysis dose and high-flux membrane in hemodialysis",
             "briefDesignDescription" : "Tolvaptan in acute HF in HFrEF",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021583",
             "fulltexturl" : null,
             "pageid" : 2771,
             "pageid" : 1345,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021583",
             "pdfurl" : "http://jama.jamanetwork.com/data/Journals/JAMA/5131/joc70029_1319_1331.pdf",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Rose EA, <i>et al</i>. \"Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis\". <i>The New England Journal of Medicine</i>. 2002. 347(25):2020-2019.",
             "citation" : "Konstam MA, <i>et al</i>. \"The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure\". <i>The Journal of the American Medical Association</i>. 2007. 297(12):1319-1331.",
             "subspecialties" : "Nephrology",
             "subspecialties" : "Cardiology",
             "expansion" : "Hemodialysis",
             "expansion" : "Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan",
             "statusUsableDate" : "2018-03-15",
             "statusUsableDate" : "2013-06-01",
             "briefResultsDescription" : "High dialysis dose and high-flux membrane did not reduce all-cause mortality",
             "briefResultsDescription" : "No benefit from tolvaptan when given for 60 days after acute HF episode",
             "published" : "2002-12-19",
             "published" : "2007-03-28",
             "pageName" : "HEMO",
             "pageName" : "EVEREST-Outcomes",
             "diseases" : "Chronic Kidney Disease",
             "diseases" : "Heart Failure",
             "abbreviation" : "HEMO",
             "abbreviation" : "EVEREST",
             "title" : "Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis",
             "title" : "The Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure",
             "pmid" : "12490682"
             "pmid" : "17384437"
         },
         },
         {
         {
             "timestamp" : "2013-10-09T17:11:02Z",
             "timestamp" : "2024-06-27T19:03:26Z",
             "briefDesignDescription" : "Trastuzumab in breast cancer",
             "briefDesignDescription" : "TAVR in low-risk patients",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052306",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1816885",
             "pageid" : 440,
             "pageid" : 4061,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052306",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1816885",
             "trainingLevel" : "Resident",
             "trainingLevel" : "resident",
             "citation" : "Piccart-Gebhart MJ, <i>et al</i>. \"Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer\". <i>The New England Journal of Medicine</i>. 2005. 353(16):1659-72.",
             "citation" : "Popma JJ, <i>et al</i>. \"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients\". <i>The New England Journal of Medicine</i>. 2019. 380(18):1706-1715.",
             "subspecialties" : "Oncology",
             "subspecialties" : "Cardiology",
             "expansion" : "Herceptin Adjuvant Trial",
             "expansion" : "",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2024-06-27",
             "briefResultsDescription" : "Trastuzumab improves survival",
             "briefResultsDescription" : "TAVR non-inferior to surgery at 24 months in low-risk patients",
             "published" : "2005-10-20",
             "published" : "2019-05-02",
             "pageName" : "HERA",
             "pageName" : "Evolut Low Risk",
             "diseases" : "Breast Cancer",
             "diseases" : "Aortic Stenosis",
             "abbreviation" : "HERA",
             "abbreviation" : "",
             "title" : "Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer",
             "title" : "Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients",
             "pmid" : "16236737"
             "pmid" : "30883053"
         },
         },
         {
         {
             "timestamp" : "2020-10-29T17:37:34Z",
             "timestamp" : "2017-12-03T22:35:28Z",
             "briefDesignDescription" : "Edoxaban vs. LMWH in cancer VTE",
             "briefDesignDescription" : "Cinacalcet in ESRD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711948",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205624",
             "pageid" : 3509,
             "pageid" : 2426,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711948",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205624",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Raskob GE, <i>et al</i>. \"Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2018. 378(7):615-624.",
             "citation" : "Chertow GM, <i>et al</i>. \"Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis\". <i>The New England Journal of Medicine</i>. 2012. 367(26):2482-2494.",
             "subspecialties" : "Hematology;Oncology",
             "subspecialties" : "Nephrology",
             "expansion" : "",
             "expansion" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
             "statusUsableDate" : "2018-02-01",
             "statusUsableDate" : "2015-10-01",
             "briefResultsDescription" : "Edoxaban noninferior to dalteparin in cancer VTE",
             "briefResultsDescription" : "Cinecalcet did not reduce CV events in ESRD",
             "published" : "2018-02-15",
             "published" : "2012-12-27",
             "pageName" : "Hokusai-VTE",
             "pageName" : "EVOLVE",
             "diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
             "diseases" : "Chronic Kidney Disease;Cardiovascular Disease",
             "abbreviation" : "",
             "abbreviation" : "EVOLVE",
             "title" : "Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism",
             "title" : "Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis",
             "pmid" : "29231094"
             "pmid" : "23121374"
         },
         },
         {
         {
             "timestamp" : "2013-08-15T18:50:04Z",
             "timestamp" : "2017-12-03T22:35:29Z",
             "briefDesignDescription" : "Ramipril in patients with high CV risk",
             "briefDesignDescription" : "CABG vs. PCI in left main CAD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200001203420301",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1610227",
             "pageid" : 1165,
             "pageid" : 2868,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200001203420301",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1610227",
             "trainingLevel" : "intern",
             "trainingLevel" : "Resident",
             "citation" : "Yusuf S, <i>et al</i>. \"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients\". <i>The New England Journal of Medicine</i>. 2000. 342(3):145-153.",
             "citation" : "Stone GW, <i>et al</i>. \"Everolimus-eluting stents or bypass surgery for left main coronary artery disease\". <i>The New England Journal of Medicine</i>. 2016. 375(23):2223-35.",
             "subspecialties" : "Cardiology;Neurology",
             "subspecialties" : "Cardiology",
             "expansion" : "Heart Outcomes Prevention Evaluation",
             "expansion" : "XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL)",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2016-12-01",
             "briefResultsDescription" : "Ramipril reduces death, MI, and stroke",
             "briefResultsDescription" : "PCI noninferior to CABG in left main CAD with low-intermediate anatomic complexity",
             "published" : "2000-01-20",
             "published" : "2016-12-08",
             "pageName" : "HOPE",
             "pageName" : "EXCEL",
             "diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "HOPE",
             "abbreviation" : "EXCEL",
             "title" : "Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients",
             "title" : "Everolimus-eluting stents or bypass surgery for left main coronary artery disease",
             "pmid" : "10639539"
             "pmid" : "27797291"
         },
         },
         {
         {
             "timestamp" : "2020-12-31T20:42:03Z",
             "timestamp" : "2017-12-03T22:35:31Z",
             "briefDesignDescription" : "Voxelotor in sickle cell disease",
             "briefDesignDescription" : "Omalizumab in severe allergic asthma",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa1903212",
             "fulltexturl" : null,
             "pageid" : 4382,
             "pageid" : 1434,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903212",
             "pdfurl" : "http://annals.org/data/Journals/AIM/20231/0000605-201105030-00002.pdf",
             "trainingLevel" : "resident",
             "trainingLevel" : "Fellow",
             "citation" : "Vichinsky E, <i>et al</i>. \"A phase 3 randomized trial of voxelotor in sickle cell disease\". <i>The New England Journal of Medicine</i>. 2019. 381(8):509-519.",
             "citation" : "Hanania NA, <i>et al</i>. \"Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial\". <i>Annals of Internal Medicine</i>. 2011. 154(9):573-582.",
             "subspecialties" : "Hematology",
             "subspecialties" : "Allergy and Immunology;Pulmonology;Pediatrics",
             "expansion" : "Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization",
             "expansion" : "A Study of Omalizumab/Xolair in Subjects With Moderate to Severe Persistent Asthma",
             "statusUsableDate" : "2020-12-10",
             "statusUsableDate" : "2013-10-01",
             "briefResultsDescription" : "Voxelotor increases hemoglobin and reduces evidence of hemolysis",
             "briefResultsDescription" : "Omalizumab reduces asthma exacerbations",
             "published" : "2019-08-08",
             "published" : "2011-05-03",
             "pageName" : "HOPE (Sickle Cell Disease)",
             "pageName" : "EXTRA",
             "diseases" : "Sickle Cell Disease",
             "diseases" : "Asthma",
             "abbreviation" : "HOPE",
             "abbreviation" : "EXTRA",
             "title" : "A phase 3 randomized trial of voxelotor in sickle cell disease",
             "title" : "Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial",
             "pmid" : "31199090"
             "pmid" : "21536936"
         },
         },
         {
         {
             "timestamp" : "2019-09-20T14:01:16Z",
             "timestamp" : "2015-11-07T23:16:22Z",
             "briefDesignDescription" : "Statin, BP meds, both, or neither for CVD 1° prevention",
             "briefDesignDescription" : "Fluid management in ARDS",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1600177",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa062200",
             "pageid" : 2770,
             "pageid" : 24,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1600177",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa062200",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Yusuf S, <i>et al</i>. \"Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease\". <i>The New England Journal of Medicine</i>. 2016. 374(21):2032-2343.",
             "citation" : "Wiedemann HP, <i>et al</i>. \"Comparison of two fluid-management strategies in acute lung injury\". <i>The New England Journal of Medicine</i>. 2006. 354(24):2564-75.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Critical Care",
             "expansion" : "Heart Outcomes Prevention Evaluation-3",
             "expansion" : "Fluids and Catheters Treatment Trial",
             "statusUsableDate" : "2019-09-19",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Statins lower events but BP meds don't.",
             "briefResultsDescription" : "Mortality benefit of conservative fluid management in ALI/ARDS",
             "published" : "2016-05-26",
             "published" : "2006-06-15",
             "pageName" : "HOPE-3",
             "pageName" : "FACTT",
             "diseases" : "Cardiovascular Disease",
             "diseases" : "Acute Respiratory Distress Syndrome",
             "abbreviation" : "HOPE-3",
             "abbreviation" : "FACTT",
             "title" : "Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease",
             "title" : "Comparison of two fluid-management strategies in acute lung injury",
             "pmid" : "27039945"
             "pmid" : "16714767"
         },
         },
         {
         {
             "timestamp" : "2021-09-09T17:34:24Z",
             "timestamp" : "2019-02-28T18:37:32Z",
             "briefDesignDescription" : "Zoledronate vs. placebo in osteoporosis",
             "briefDesignDescription" : "Parenteral iron in HFrEF with iron deficiency",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa067312",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa0908355",
             "pageid" : 2765,
             "pageid" : 2691,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa067312",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa0908355",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Black DM, <i>et al</i>. \"Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis\". <i>The New England Journal of Medicine</i>. 2007. 356(18):1809-22.",
             "citation" : "Anker SD, <i>et al</i>. \"Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency\". <i>The New England Journal of Medicine</i>. 2009. 361(25):2436-48.",
             "subspecialties" : "Endocrinology;Preventive Medicine",
             "subspecialties" : "Cardiology;Hematology",
             "expansion" : "Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial",
             "expansion" : "IV Iron for Symptoms in Patients with HFrEF and Iron Deficiency",
             "statusUsableDate" : "2021-08-31",
             "statusUsableDate" : "2019-03-01",
             "briefResultsDescription" : "Annual zoledronate reduces fracture risk in osteoporosis",
             "briefResultsDescription" : "IV iron improves HFrEF symptoms in patients with HFrEF and iron deficiency",
             "published" : "2007-05-03",
             "published" : "2009-12-17",
             "pageName" : "HORIZON-PFT",
             "pageName" : "FAIR-HF",
             "diseases" : "Osteoporosis",
             "diseases" : "Heart Failure;Iron Deficiency Anemia",
             "abbreviation" : "HORIZON-PFT",
             "abbreviation" : "FAIR-HF",
             "title" : "Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis",
             "title" : "Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency",
             "pmid" : "17476007"
             "pmid" : "19920054"
         },
         },
         {
         {
             "timestamp" : "2024-05-02T17:49:17Z",
             "timestamp" : "2018-01-03T20:13:15Z",
             "briefDesignDescription" : "Duration of empiric antibiotics in ↑risk neutropenic fever",
             "briefDesignDescription" : "FFR-guided PCI in stable CAD",
             "fulltexturl" : "https://doi.org/10.1016/S2352-3026(17)30211-9",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807611",
             "pageid" : 4119,
             "pageid" : 998,
             "pdfurl" : null,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807611",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "resident",
             "citation" : "Aguilar-Guisado M, <i>et al</i>. \"Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial\". <i>Lancet Haematology</i>. 2017. 4(12):e573-e583.",
             "citation" : "Tonino PAL, <i>et al</i>. \"Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention\". <i>The New England Journal of Medicine</i>. 2009. 360(3):213-224.",
             "subspecialties" : "Infectious Disease;Hematology",
             "subspecialties" : "Cardiology",
             "expansion" : null,
             "expansion" : "Fractional Flow Reserve versus Angiography for Multivessel Evaluation",
             "statusUsableDate" : "2021-03-15",
             "statusUsableDate" : "2012-10-01",
             "briefResultsDescription" : "Shorter courses of antibiotics led to fewer days of antibiotics without excess harm",
             "briefResultsDescription" : "FFR reduces composite of death, nonfatal MI, urgent revascularization",
             "published" : "2017-11-15",
             "published" : "2009-01-15",
             "pageName" : "How Long",
             "pageName" : "FAME",
             "diseases" : "Febrile Neutropenia",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : null,
             "abbreviation" : "FAME",
             "title" : "Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial",
             "title" : "Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention",
             "pmid" : "29153975"
             "pmid" : "19144937"
         },
         },
         {
         {
             "timestamp" : "2020-02-06T19:36:49Z",
             "timestamp" : "2018-07-05T13:05:28Z",
             "briefDesignDescription" : "Simvastatin in high risk for CVD",
             "briefDesignDescription" : "FFR-guided PCI vs. OMT in CAD",
             "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(02)09327-3",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1205361",
             "pageid" : 2696,
             "pageid" : 1003,
             "pdfurl" : "",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205361",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Heart Protection Study Collaborative Group Writers. \"MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial\". <i>The Lancet</i>. 2002. 360(9326):7-22.",
             "citation" : "De Bruyne B, <i>et al</i>. \"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease\". <i>The New England Journal of Medicine</i>. 2012. 367(11):991-1001.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Heart Protection Study Statin Arm",
             "expansion" : "FFR vs. Angiographyfor Multivessel Evaluation 2",
             "statusUsableDate" : "2020-02-07",
             "statusUsableDate" : "2012-11-01",
             "briefResultsDescription" : "Simvastatin reduces CVD events and death",
             "briefResultsDescription" : "FFR-guided PCI reduces urgent revascularization",
             "published" : "2002-06-06",
             "published" : "2012-09-13",
             "pageName" : "HPS Statin",
             "pageName" : "FAME 2",
             "diseases" : "Hyperlipidemia;Cardiovascular Disease",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "HPS",
             "abbreviation" : "FAME 2",
             "title" : "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial",
             "title" : "Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease",
             "pmid" : "12114036"
             "pmid" : "22924638"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:56Z",
             "timestamp" : "2017-12-03T22:35:38Z",
             "briefDesignDescription" : "Niacin in atherosclerotic disease",
             "briefDesignDescription" : "Fluid resuscitation in Sub-Saharan Africa",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300955",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1101549",
            "pageid" : 2329,
             "pageid" : 1860,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300955",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1101549",
            "trainingLevel" : "Intern",
            "citation" : "Landray MJ <i>et al</i>. \"Effects of extended-release niacin with laropiprant in high-risk patients\". <i>The New England Journal of Medicine</i>. 2014. 371(3):203-212.",
            "subspecialties" : "Cardiology",
            "expansion" : "Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events",
            "statusUsableDate" : "2015-02-01",
            "briefResultsDescription" : "Niacin is poorly tolerated, doesn't reduce major vascular events",
            "published" : "2014-07-17",
            "pageName" : "HPS2-THRIVE",
            "diseases" : "Coronary Artery Disease;Peripheral Vascular Disease",
            "abbreviation" : "HPS2-THRIVE",
            "title" : "Effects of extended-release niacin with laropiprant in high-risk patients",
            "pmid" : "25014686"
        },
        {
            "timestamp" : "2017-12-03T22:35:58Z",
            "briefDesignDescription" : "Early ART in HIV",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1105243",
             "pageid" : 1010,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1105243",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Cohen MS, <i>et al</i>. \"Prevention of HIV-1 Infection with Early Antiretroviral Therapy\". <i>The New England Journal of Medicine</i>. 2011. 365(6):493-505.",
             "citation" : "Maitland K, <i>et al</i>. \"Mortality after fluid bolus in African children with severe infection\". <i>The New England Journal of Medicine</i>. 2011. 364(26):2483-2495.",
             "subspecialties" : "Infectious Disease",
             "subspecialties" : "Pediatrics;Critical Care",
             "expansion" : "HIV Prevention Trials Network 052 Study",
             "expansion" : "Fluid Expansion as Supportive Therapy",
             "statusUsableDate" : "2012-10-01",
             "statusUsableDate" : "2014-11-01",
             "briefResultsDescription" : "Reduced morbidity and HIV transmission",
             "briefResultsDescription" : "Albumin and saline increase mortality when compared to no fluids in this patient population",
             "published" : "2011-08-11",
             "published" : "2011-06-30",
             "pageName" : "HPTN 052",
             "pageName" : "FEAST",
             "diseases" : "HIV",
             "diseases" : "Shock",
             "abbreviation" : "HPTN 052",
             "abbreviation" : "FEAST",
             "title" : "Prevention of HIV-1 Infection with Early Antiretroviral Therapy",
             "title" : "Mortality after fluid bolus in African children with severe infection",
             "pmid" : "21767103"
             "pmid" : "21615299"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:35:59Z",
             "timestamp" : "2013-10-07T20:50:13Z",
             "briefDesignDescription" : "High sensitivity troponin for acute chest pain",
             "briefDesignDescription" : "Fidaxomicin in C. difficile",
             "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109714017264",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0910812",
             "pageid" : 2343,
             "pageid" : 255,
             "pdfurl" : null,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0910812",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Bandstein N, <i>et al</i>. \"Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction\". <i>Journal of the American College of Cardiology</i>. 2014. 63(23):2569-2578.",
             "citation" : "Louie TJ, <i>et al</i>. \"Fidaxomicin versus Vancomycin for Clostridium difficile Infection\". <i>The New England Journal of Medicine</i>. 2011. 365(5):422-431.",
             "subspecialties" : "Emergency Medicine;Cardiology",
             "subspecialties" : "Infectious Disease;Gastroenterology",
             "expansion" : null,
             "expansion" : null,
             "statusUsableDate" : "2015-03-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "HS troponin-T is associated with high NPV for MI at 30 days",
             "briefResultsDescription" : "Fidaxomicin noninferior to vancomycin for cure, and resulted in 45% fewer recurrences",
             "published" : "2014-06-17",
             "published" : "2011-02-03",
             "pageName" : "HS troponin-T to rule out MI",
             "pageName" : "Fidaxomicin in C. difficile Diarrhea",
             "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
             "diseases" : "Clostridium difficile",
             "abbreviation" : null,
             "abbreviation" : null,
             "title" : "Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction",
             "title" : "Fidaxomicin versus Vancomycin for Clostridium difficile Infection",
             "pmid" : "24694529"
             "pmid" : "21288078"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:04Z",
             "timestamp" : "2024-10-17T17:57:15Z",
             "briefDesignDescription" : "Perinatal vitamins to prevent neural tube defects",
             "briefDesignDescription" : "Mineralocorticoid antagonist in CKD/T2DM",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199212243272602",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa2025845",
             "pageid" : 2142,
             "pageid" : 4384,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199212243272602",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2025845",
             "trainingLevel" : "Student",
             "trainingLevel" : "Resident",
             "citation" : "Czeizel AE and Dudas I. \"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation\". <i>The New England Journal of Medicine</i>. 1992. 327(26):1832-1835.",
             "citation" : "Bakris GL, <i>et al</i>. \"Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2020. 383(23):2219-2229.",
             "subspecialties" : "Obstetrics;Preventive Medicine",
             "subspecialties" : "Nephrology;Endocrinology",
             "expansion" : null,
             "expansion" : "Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease",
             "statusUsableDate" : "2014-09-01",
             "statusUsableDate" : "2024-10-17",
             "briefResultsDescription" : "Perinatal vitamins reduce neural tube defects",
             "briefResultsDescription" : "Mineralocorticoid antagonist slows CKD progression",
             "published" : "1992-12-24",
             "published" : "2020-10-23",
             "pageName" : "Hungarian Prenatal Vitamin Trial",
             "pageName" : "FIDELIO-DKD",
             "diseases" : "Neural Tube Defects",
             "diseases" : "Chronic Kidney Disease;Diabetes Mellitus",
             "abbreviation" : null,
             "abbreviation" : "FIDELIO-DKD",
             "title" : "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation",
             "title" : "Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes",
             "pmid" : "1307234"
             "pmid" : "33264825"
         },
         },
         {
         {
             "timestamp" : "2023-11-22T21:12:44Z",
             "timestamp" : "2017-12-03T22:35:39Z",
             "briefDesignDescription" : "Hydrocortisone, Vit C, and thiamine in sepsis",
             "briefDesignDescription" : "Cryoablation vs. RF ablation in pAF",
             "fulltexturl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1602014",
             "pageid" : 2946,
             "pageid" : 2795,
             "pdfurl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602014",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Marik PE, <i>et al</i>. \"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study\". <i>Chest</i>. 2017. 151(6):1229-1238.",
             "citation" : "Kuck K, <i>et al</i>. \"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation\". <i>The New England Journal of Medicine</i>. 2016. 374(23):2235-45.",
             "subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "",
             "statusUsableDate" : "2018-08-13",
             "statusUsableDate" : "2016-07-01",
             "briefResultsDescription" : "Pilot study with impressive findings, low-quality data",
             "briefResultsDescription" : "Cryoablation equivalent to RF ablation in pAF",
             "published" : "2017-06-01",
             "published" : "2016-06-09",
             "pageName" : "Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock",
             "pageName" : "FIRE AND ICE",
             "diseases" : "Sepsis;Shock",
             "diseases" : "Atrial Fibrillation",
             "abbreviation" : "",
             "abbreviation" : "FIRE AND ICE",
             "title" : "Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study",
             "title" : "Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation",
             "pmid" : "27940189"
             "pmid" : "27042964"
         },
         },
         {
         {
             "timestamp" : "2018-02-08T17:14:46Z",
             "timestamp" : "2017-12-03T22:35:41Z",
             "briefDesignDescription" : "Hydrocortisone in severe sepsis",
             "briefDesignDescription" : "LABA+LAMA vs. LABA+ICS in COPD",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMsa1410639",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1516385",
             "pageid" : 2860,
             "pageid" : 2871,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMsa1410639",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1516385",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Keh D, <i>et al</i>. \"Effect of hydrocortisone on development of shock among patients with severe sepsis\". <i>Journal of the American Medical Association</i>. 2016. 316(17):1775-1785.",
             "citation" : "Wedzicha JA, <i>et al</i>. \"Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD\". <i>The New England Journal of Medicine</i>. 2016. 374(23):2222-2234.",
             "subspecialties" : "Critical Care",
             "subspecialties" : "Pulmonology",
             "expansion" : "",
             "expansion" : "Effect of Indacaterol Glycopyronium Vs. Fluticasone Salmeterol on COPD Exacerbations",
             "statusUsableDate" : "2016-11-01",
             "statusUsableDate" : "2017-01-01",
             "briefResultsDescription" : "Hydrocortisone not superior to placebo in severe sepsis",
             "briefResultsDescription" : "LABA+LAMA reduces COPD exacerbations",
             "published" : "2016-10-03",
             "published" : "2016-06-09",
             "pageName" : "HYPRESS",
             "pageName" : "FLAME (COPD)",
             "diseases" : "Sepsis",
             "diseases" : "Emphysema;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease",
             "abbreviation" : "HYPRESS",
             "abbreviation" : "FLAME COPD",
             "title" : "Effect of hydrocortisone on development of shock among patients with severe sepsis",
             "title" : "Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD",
             "pmid" : "27695824"
             "pmid" : "27181606"
         },
         },
         {
         {
             "timestamp" : "2018-01-11T18:14:28Z",
             "timestamp" : "2018-10-08T21:47:35Z",
             "briefDesignDescription" : "Elderly HTN treatment",
             "briefDesignDescription" : "SSRI after CVA for motor recovery",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801369",
             "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S1474-4422(10)70314-8",
             "pageid" : 2349,
             "pageid" : 2370,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801369",
             "pdfurl" : "",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Beckett NS, <i>et al</i>. \"Treatment of hypertension in patients 80 years of age or older\". <i>The New England Journal of Medicine</i>. 2008. 358(18):1887-1898.",
             "citation" : "Chollet F, <i>et al</i>. \"Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial\". <i>The Lancet Neurology</i>. 2011. 10(2):123-130.",
             "subspecialties" : "Nephrology;Cardiology;Geriatrics",
             "subspecialties" : "Neurology",
             "expansion" : "Hypertension in the Very Elderly Trial",
             "expansion" : "Fluoxetine for Motor Recovery after Acute Ischaemic Stroke",
             "statusUsableDate" : "2015-04-01",
             "statusUsableDate" : "2015-08-01",
             "briefResultsDescription" : "Trend towards reduction in stroke with treatment (P",
             "briefResultsDescription" : "Early fluoxetine improved motor outcomes post stroke",
             "published" : "2008-05-01",
             "published" : "2011-02-01",
             "pageName" : "HYVET",
             "pageName" : "FLAME (Stroke)",
             "diseases" : "Hypertension",
             "diseases" : "Stroke",
             "abbreviation" : "HYVET",
             "abbreviation" : "FLAME",
             "title" : "Treatment of hypertension in patients 80 years of age or older",
             "title" : "Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial",
             "pmid" : "18378519"
             "pmid" : "21216670"
         },
         },
         {
         {
             "timestamp" : "2017-09-24T13:54:35Z",
             "timestamp" : "2024-10-03T17:48:57Z",
             "briefDesignDescription" : "IABP in MI and cardiogenic shock",
             "briefDesignDescription" : "High-flow oxygen in respiratory failure",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208410",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1503326",
             "pageid" : 1065,
             "pageid" : 2375,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208410",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1503326",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Intern",
             "citation" : "Thiele H, <i>et al</i>. \"Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock\". <i>The New England Journal of Medicine</i>. 2012. 367(14):1287-1296.",
             "citation" : "Frat JP, <i>et al</i>. \"High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure\". <i>The New England Journal of Medicine</i>. 2015. 372(23):2185-2196.",
             "subspecialties" : "Cardiology;Critical Care",
             "subspecialties" : "Pulmonology;Critical Care Medicine",
             "expansion" : "Intraaortic Balloon Pump in Cardiogenic Shock II",
             "expansion" : "",
             "statusUsableDate" : "2012-03-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "IABP did not reduce mortality at 30 days",
             "briefResultsDescription" : "High-flow oxygen therapy reduces intubation need",
             "published" : "2012-10-10",
             "published" : "2015-06-04",
             "pageName" : "IABP-SHOCK II",
             "pageName" : "FLORALI",
             "diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
             "diseases" : "Hypoxemic Respiratory Failure",
             "abbreviation" : "IABP-SHOCK II",
             "abbreviation" : "FLORALI",
             "title" : "Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock",
             "title" : "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure",
             "pmid" : "22920912"
             "pmid" : "25981908"
         },
         },
         {
         {
             "timestamp" : "2019-05-23T17:29:10Z",
             "timestamp" : "2017-12-14T18:13:26Z",
             "briefDesignDescription" : "Adjuvant cisplatin in resected NSCLC",
             "briefDesignDescription" : "Transfusion thresholds after hip surgery",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa031644",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1012452",
             "pageid" : 2503,
             "pageid" : 2985,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa031644",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1012452",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Arriagada R, <i>et al</i>. \"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer\". <i>The New England Journal of Medicine</i>. 2004. 350(4):351-360.",
             "citation" : "Carson JL, <i>et al</i>. \"Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery\". <i>The New england Journal of Medicine</i>. 2011. 365(26):2453-62.",
             "subspecialties" : "Oncology",
             "subspecialties" : "Hematology;Surgery",
             "expansion" : "International Adjuvant Lung Cancer Trial",
             "expansion" : "Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair",
             "statusUsableDate" : "2019-05-23",
             "statusUsableDate" : "2017-12-14",
             "briefResultsDescription" : "Adjuvant cisplatin improves 5-year OS in resected NSCLC",
             "briefResultsDescription" : "Liberal transfusions no better than restrictive",
             "published" : "2004-01-22",
             "published" : "2011-12-29",
             "pageName" : "IALT",
             "pageName" : "FOCUS",
             "diseases" : "Lung Cancer",
             "diseases" : "Hip Fracture;Anemia",
             "abbreviation" : "IALT",
             "abbreviation" : "FOCUS",
             "title" : "Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer",
             "title" : "Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery",
             "pmid" : "14736927"
             "pmid" : "22168590"
         },
         },
         {
         {
             "timestamp" : "2021-11-04T17:33:05Z",
             "timestamp" : "2020-11-05T18:42:16Z",
             "briefDesignDescription" : "Second-line ibrutinib in WM",
             "briefDesignDescription" : "Evolocumab for CVD events if atherosclerotic disease",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501548",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1615664",
             "pageid" : 2660,
             "pageid" : 2891,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501548",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1615664",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Treon SP, <i>et al</i>. \"Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia\". <i>The New England Journal of Medicine</i>. 2015. 372(15):1430-1440.",
             "citation" : "Sabatine MS, <i>et al</i>. \"Evolocumab and clinical outcomes in patients with cardiovascular disease\". <i>The New England Journal of Medicine</i>. 2017. epub 2017-03-17:1-10.",
             "subspecialties" : "Hematology",
             "subspecialties" : "Cardiology",
             "expansion" : null,
             "expansion" : "Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk",
             "statusUsableDate" : "2015-12-01",
             "statusUsableDate" : "2017-03-01",
             "briefResultsDescription" : "Ibrutinib is safe and effective in previously treated WM",
             "briefResultsDescription" : "Evolocumab reduces CV events in patients with atherosclerotic disease",
             "published" : "2015-04-09",
             "published" : "2017-03-17",
             "pageName" : "Ibrutinib in Waldenstrom macroglobulinemia",
             "pageName" : "FOURIER",
             "diseases" : "Lymphoma;Waldenström Macroglobulinemia",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : null,
             "abbreviation" : "FOURIER",
             "title" : "Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia",
             "title" : "Evolocumab and clinical outcomes in patients with cardiovascular disease",
             "pmid" : "25853747"
             "pmid" : "28304224"
         },
         },
         {
         {
             "timestamp" : "2020-02-10T07:03:58Z",
             "timestamp" : "2017-12-03T22:35:45Z",
             "briefDesignDescription" : "Ibrutinib-rituximab vs. FCR in untreated CLL",
             "briefDesignDescription" : "CABG vs. PCI for CAD in T2DM",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1817073",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1211585",
             "pageid" : 4175,
             "pageid" : 2314,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817073",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1211585",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Shanafelt TD, <i>et al</i>. \"Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia\". <i>The New England Journal of Medicine</i>. 2019. 381(5):432-43.",
             "citation" : "Farkouh ME, <i>et al</i>. \"Strategies for multivessel revascularization in patients with diabetes\". <i>The New England Journal of Medicine</i>. 2012. 367(25):2375-2384.",
             "subspecialties" : "Hematology;Oncology",
             "subspecialties" : "Cardiology;Endocrinology",
             "expansion" : "",
             "expansion" : "Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease",
             "statusUsableDate" : "2020-02-09",
             "statusUsableDate" : "2016-04-01",
             "briefResultsDescription" : "IR improved survival over FCR in untreated CLL",
             "briefResultsDescription" : "CABG reduces death and revascularization rates but causes more strokes",
             "published" : "2019-08-01",
             "published" : "2012-12-20",
             "pageName" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
             "pageName" : "FREEDOM",
             "diseases" : "Chronic Lymphocytic Leukemia;Small Lymphocytic Lymphoma",
             "diseases" : "Coronary Artery Disease;Diabetes Mellitus",
             "abbreviation" : "E1912",
             "abbreviation" : "FREEDOM",
             "title" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
             "title" : "Strategies for multivessel revascularization in patients with diabetes",
             "pmid" : "31365801"
             "pmid" : "23121323"
         },
         },
         {
         {
             "timestamp" : "2018-10-16T05:02:38Z",
             "timestamp" : "2021-06-01T13:47:49Z",
             "briefDesignDescription" : "Colchicine in the first episode of acute pericarditis",
             "briefDesignDescription" : "Early invasive strategy in UA/NSTEMI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208536",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07349-3/fulltext",
             "pageid" : 1729,
             "pageid" : 2451,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208536",
             "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(99)07349-3.pdf",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Imazio M, <i>et al</i>. \"A Randomized Trial of Colchicine for Acute Pericarditis\". <i>The New England Journal of Medicine</i>. 2013. 369(16):1522-1528.",
             "citation" : "FRISC Investigators. \"Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study\". <i>The Lancet</i>. 1999. 354(9180):708-15.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Evaluation of additive benefit of colchicine to conventional therapy in acute pericarditis",
             "expansion" : "FRagmin and Fast Revascularisation during InStability in Coronary artery disease-II",
             "statusUsableDate" : "2014-01-01",
             "statusUsableDate" : "2015-11-01",
             "briefResultsDescription" : "Colchicine reduces incessant or recurrent acute pericarditis when used in first episode",
             "briefResultsDescription" : "Fewer recurrent MIs with early invasive strategy in high-risk patients",
             "published" : "2013-10-17",
             "published" : "1999-08-28",
             "pageName" : "ICAP",
             "pageName" : "FRISC-II",
             "diseases" : "Pericarditis",
             "diseases" : "Coronary Artery Disease;Myocardial Infarction;Acute Coronary Syndrome",
             "abbreviation" : "ICAP",
             "abbreviation" : "FRISC-II",
             "title" : "A Randomized Trial of Colchicine for Acute Pericarditis",
             "title" : "Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study",
             "pmid" : "23992557"
             "pmid" : "10475181"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:07Z",
             "timestamp" : "2017-12-03T22:35:49Z",
             "briefDesignDescription" : "Early vs. late dialysis in CKD",
             "briefDesignDescription" : "Risk factors for GI bleeds in ICU patients",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000552",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199402103300601",
             "pageid" : 1020,
             "pageid" : 391,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000552",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199402103300601",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Intern",
             "citation" : "Cooper BA, <i>et al</i>. \"A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis\". <i>The New England Journal of Medicine</i>. 2010. 363(7):609-619.",
             "citation" : "Cook DJ, <i>et al</i>. \"Risk factors for gastrointestinal bleeding in critically ill patients\". <i>The New England Journal of Medicine</i>. 1994. 330(6):337-381.",
             "subspecialties" : "Nephrology",
             "subspecialties" : "Critical Care;Gastroenterology",
             "expansion" : "Initiating Dialysis Early and Late",
             "expansion" : null,
             "statusUsableDate" : "2012-10-01",
             "statusUsableDate" : "2013-10-01",
             "briefResultsDescription" : "No difference in survival or clinical outcomes",
             "briefResultsDescription" : "Greatest risk for GI bleed with coagulopathy and mechanical ventilation",
             "published" : "2010-08-12",
             "published" : "1994-02-10",
             "pageName" : "IDEAL",
             "pageName" : "GI bleeding in ICU patients",
             "diseases" : "Chronic Kidney Disease",
             "diseases" : "Gastrointestinal Hemorrhage",
             "abbreviation" : "IDEAL",
             "abbreviation" : null,
             "title" : "A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis",
             "title" : "Risk factors for gastrointestinal bleeding in critically ill patients",
             "pmid" : "20581422"
             "pmid" : "8284001"
         },
         },
         {
         {
             "timestamp" : "2019-03-27T18:27:05Z",
             "timestamp" : "2014-09-24T22:28:37Z",
             "briefDesignDescription" : "Early vs. delayed RRT in septic shock",
             "briefDesignDescription" : "Lisinopril in acute MI",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1803213",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2894%2990232-1/abstract",
             "pageid" : 3746,
             "pageid" : 258,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1803213",
             "pdfurl" : "",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Barbar SD, <i>et al</i>. \"Timing of renal-replacement therapy in patients with acute kidney injury and sepsis\". <i>The New England Journal of Medicine</i>. 2018. 379(15):1431-1442.",
             "citation" : "GISSI-3 Group. \"Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction\". <i>The Lancet</i>. 1994. 343(8906):1115-22.",
             "subspecialties" : "Critical Care;Nephrology",
             "subspecialties" : "Cardiology",
             "expansion" : "Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit",
             "expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico",
             "statusUsableDate" : "2019-03-27",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "No benefit from early initiated RRT in septic shock",
             "briefResultsDescription" : "Lisinopril improves 6-week mortality",
             "published" : "2018-10-11",
             "published" : "1994-05-07",
             "pageName" : "IDEAL-ICU",
             "pageName" : "GISSI-3",
             "diseases" : "Acute Kidney Injury;Septic Shock",
             "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
             "abbreviation" : "IDEAL-ICU",
             "abbreviation" : "GISSI-3",
             "title" : "Timing of renal-replacement therapy in patients with acute kidney injury and sepsis",
             "title" : "Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction",
             "pmid" : "30304656"
             "pmid" : "7910229"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:08Z",
             "timestamp" : "2023-08-03T17:47:16Z",
             "briefDesignDescription" : "ARBs in diabetic nephropathy",
             "briefDesignDescription" : "PUFA in patients with heart failure",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011303",
             "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(08)61239-8/fulltext",
             "pageid" : 2670,
             "pageid" : 2824,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011303",
             "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)61239-8.pdf",
             "trainingLevel" : "Resident",
             "trainingLevel" : "intern",
             "citation" : "Lewis EJ, <i>et al</i>. \"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2001. 345(12):851-860.",
             "citation" : "Tavazzi L, <i>et al</i>. \"Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure\". <i>The Lancet</i>. 2008. 372(9645):1223-1230.",
             "subspecialties" : "Nephrology;Endocrinology",
             "subspecialties" : "Cardiology",
             "expansion" : "Irbesartan Diabetic Nephropathy Trial",
             "expansion" : "Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione",
             "statusUsableDate" : "2016-01-01",
             "statusUsableDate" : "2023-07-31",
             "briefResultsDescription" : "ARBs prevent progression of T2DM nephropathy",
             "briefResultsDescription" : "PUFA reduces all-cause mortality and admission for CV disease",
             "published" : "2001-09-20",
             "published" : "2008-10-04",
             "pageName" : "IDNT",
             "pageName" : "GISSI-HF",
             "diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
             "diseases" : "Heart failure",
             "abbreviation" : "IDNT",
             "abbreviation" : "GISSI-HF",
             "title" : "Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes",
             "title" : "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure",
             "pmid" : "11565517"
             "pmid" : "18757090"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:10Z",
             "timestamp" : "2017-12-03T22:35:51Z",
             "briefDesignDescription" : "iFR vs. FFR for PCI",
             "briefDesignDescription" : "tPA in ACS",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1616540",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199309023291001",
             "pageid" : 2926,
             "pageid" : 2177,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1616540",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199309023291001",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Student",
             "citation" : "Gotberg M, <i>et al</i>. \"Spontaneous wave-free ratio versus fractional flow reserve to guide PCI\". <i>The New England Journal of Medicine</i>. 2017. 376(19):1813-1823.",
             "citation" : "Topol E, <i>et al</i>. \"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction\". <i>The New England Journal of Medicine</i>. 1993. 329(10):673-682.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome",
             "expansion" : "Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries",
             "statusUsableDate" : "2017-05-01",
             "statusUsableDate" : "2014-09-01",
             "briefResultsDescription" : "iFR noninferior to FFR for PCI",
             "briefResultsDescription" : "tPA reduces mortality in ACS",
             "published" : "2017-05-11",
             "published" : "1993-09-03",
             "pageName" : "IFR-SWEDEHEART",
             "pageName" : "GUSTO",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Myocardial Infarction;Acute Coronary Syndrome",
             "abbreviation" : "iFR-SWEDEHEART",
             "abbreviation" : "GUSTO",
             "title" : "Spontaneous wave-free ratio versus fractional flow reserve to guide PCI",
             "title" : "An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction",
             "pmid" : "28317438"
             "pmid" : "8204123"
         },
         },
         {
         {
             "timestamp" : "2017-12-14T19:46:19Z",
             "timestamp" : "2024-08-25T20:47:09Z",
             "briefDesignDescription" : "Ezetimibe+simvastatin after ACS",
             "briefDesignDescription" : "Hypothermia for cardiac arrest",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1410489",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/nejmoa012689",
             "pageid" : 2369,
             "pageid" : 410,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/nejmoa012689",
             "trainingLevel" : "Intern",
             "trainingLevel" : "Resident",
             "citation" : "Cannon CP, <i>et al</i>. \"Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2015. 375(25):2387-2397.",
             "citation" : "Holzer M, <i>et al</i>. \"Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest\". <i>The New England Journal of Medicine</i>. 2002. 346(8):549-556.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Critical Care;Neurology;Cardiology",
             "expansion" : "IMProved Reduction of Outcomes: Vytorin Efficacy International Trial",
             "expansion" : "Hypothermia After Cardiac Arrest",
             "statusUsableDate" : "2015-06-01",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Ezetimibe improves CV outcomes when added to statin",
             "briefResultsDescription" : "Hypothermia improves neurologic outcomes and reduces mortality",
             "published" : "2015-06-18",
             "published" : "2002-02-21",
             "pageName" : "IMPROVE-IT",
             "pageName" : "HACA",
             "diseases" : "Hyperlipidemia;Acute Coronary Syndrome;Myocardial Infarction",
             "diseases" : "Cardiac Arrest",
             "abbreviation" : "IMPROVE-IT",
             "abbreviation" : "HACA",
             "title" : "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes",
             "title" : "Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest",
             "pmid" : "26039521"
             "pmid" : "11856793"
         },
         },
         {
         {
             "timestamp" : "2018-03-30T14:11:39Z",
             "timestamp" : "2017-12-03T22:35:53Z",
             "briefDesignDescription" : "Nintedanib in IPF",
             "briefDesignDescription" : "Continuous-flow LVAD in heart failure",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402584",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0909938#t",
             "pageid" : 2934,
             "pageid" : 2808,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402584",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0909938",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Fellow",
             "citation" : "Richeldi L, <i>et al</i>. \"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis\". <i>The New England Journal of Medicine</i>. 2014. 370(22):2071-2082.",
             "citation" : "Slaughter MS, <i>et al</i>. \"Advanced heart failure treated with continuous-flow left ventricular assist device\". <i>The New England Journal of Medicine</i>. 2009. 361(23):2241-2251.",
             "subspecialties" : "Pulmonology",
             "subspecialties" : "Cardiology",
             "expansion" : "",
             "expansion" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
             "statusUsableDate" : "2018-03-30",
             "statusUsableDate" : "2016-09-01",
             "briefResultsDescription" : "Nintedanib slows progression of IPF",
             "briefResultsDescription" : "Continuous-flow LVAD improved survival free from stroke and device failure",
             "published" : "2014-05-29",
             "published" : "2009-12-03",
             "pageName" : "INPULSIS Trials",
             "pageName" : "HEARTMATE II",
             "diseases" : "Idiopathic Pulmonary Fibrosis",
             "diseases" : "Heart Failure",
             "abbreviation" : "INPULSIS I and II",
             "abbreviation" : "HEARTMATE II",
             "title" : "Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis",
             "title" : "Advanced heart failure treated with continuous-flow left ventricular assist device",
             "pmid" : "24836310"
             "pmid" : "19920051"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:12Z",
             "timestamp" : "2020-11-04T18:25:05Z",
             "briefDesignDescription" : "Early vs. delayed ART in HIV",
             "briefDesignDescription" : "Acetaminophen in febrile ICU patients",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506816",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1508375",
             "pageid" : 2468,
             "pageid" : 2690,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506816",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1508375",
             "trainingLevel" : "Student",
             "trainingLevel" : "Intern",
             "citation" : "INSIGHT START Writers. \"Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection\". <i>The New England Journal of Medicine</i>. 2015. 373(9):795-807.",
             "citation" : "Young P, <i>et al</i>. \"Acetaminophen for Fever in Critically Ill Patients with Suspected Infection\". <i>The New England Journal of Medicine</i>. 2015. 373(23):2215-2224.",
             "subspecialties" : "Infectious Disease",
             "subspecialties" : "Critical Care;Infectious Disease",
             "expansion" : null,
             "expansion" : "Permissive Hyperthermia through Avoidance of Acetaminophen in Known or Suspected Infection in the Intensive Care Unit",
             "statusUsableDate" : "2016-01-01",
             "statusUsableDate" : "2017-09-01",
             "briefResultsDescription" : "Less complications with early ART",
             "briefResultsDescription" : "Acetaminophen does not improves ICU outcomes",
             "published" : "2015-08-27",
             "published" : "2015-12-03",
             "pageName" : "INSIGHT START",
             "pageName" : "HEAT",
             "diseases" : "HIV",
             "diseases" : "Sepsis;Fever",
             "abbreviation" : "START",
             "abbreviation" : "HEAT",
             "title" : "Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection",
             "title" : "Acetaminophen for Fever in Critically Ill Patients with Suspected Infection",
             "pmid" : "26192873"
             "pmid" : "26436473"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:14Z",
             "timestamp" : "2023-02-02T19:36:38Z",
             "briefDesignDescription" : "ART in primary HIV prevention",
             "briefDesignDescription" : "Heparin vs. bivalirudin in PCI",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011205",
             "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(14)60924-7",
             "pageid" : 1100,
             "pageid" : 2394,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011205",
             "pdfurl" : "",
             "trainingLevel" : "intern",
             "trainingLevel" : "Resident",
             "citation" : "Grant RM, <i>et al</i>. \"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men\". <i>The New England Journal of Medicine</i>. 2010. 363(27):2587-2599.",
             "citation" : "Shahzad A, <i>et al</i>. \"Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.\". <i>The Lancet</i>. 2014. 384(9957):1849-1858.",
             "subspecialties" : "Infectious Disease;Preventive Medicine",
             "subspecialties" : "Cardiology",
             "expansion" : "Iniciativa Profilaxis Pre Exposicion (\"Preexposure Prophylaxis Initiative\")",
             "expansion" : "",
             "statusUsableDate" : "2013-02-01",
             "statusUsableDate" : "2023-01-29",
             "briefResultsDescription" : "ART reduces tranmission of HIV among MSM",
             "briefResultsDescription" : "Heparin better than bivalirudin for PCI",
             "published" : "2010-12-30",
             "published" : "2014-11-22",
             "pageName" : "IPrEx",
             "pageName" : "HEAT-PPCI",
             "diseases" : "HIV",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "iPrEx",
             "abbreviation" : "HEAT-PPCI",
             "title" : "Preexposure chemoprophylaxis for HIV prevention in men who have sex with men",
             "title" : "Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.",
             "pmid" : "21091279"
             "pmid" : "25002178"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:15Z",
             "timestamp" : "2018-10-25T17:06:10Z",
             "briefDesignDescription" : "Imatinib vs. IFNα/cytarabine in CML",
             "briefDesignDescription" : "High dialysis dose and high-flux membrane in hemodialysis",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa022457",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa021583",
             "pageid" : 1076,
             "pageid" : 2771,
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa022457",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa021583",
             "trainingLevel" : "Student",
             "trainingLevel" : "Fellow",
             "citation" : "O'Brien SG, <i>et al</i>. \"Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia\". <i>The New England Journal of Medicine</i>. 2003. 384(11):994-1004.",
             "citation" : "Rose EA, <i>et al</i>. \"Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis\". <i>The New England Journal of Medicine</i>. 2002. 347(25):2020-2019.",
             "subspecialties" : "Hematology;Oncology",
             "subspecialties" : "Nephrology",
             "expansion" : "International Randomized Study of Interferon and STI571",
             "expansion" : "Hemodialysis",
             "statusUsableDate" : "2012-11-01",
             "statusUsableDate" : "2018-03-15",
             "briefResultsDescription" : "Imatinib delays disease progression",
             "briefResultsDescription" : "High dialysis dose and high-flux membrane did not reduce all-cause mortality",
             "published" : "2003-03-13",
             "published" : "2002-12-19",
             "pageName" : "IRIS",
             "pageName" : "HEMO",
             "diseases" : "Chronic Myeloid Leukemia;Myeloproliferative Neoplasms",
             "diseases" : "Chronic Kidney Disease",
             "abbreviation" : "IRIS",
             "abbreviation" : "HEMO",
             "title" : "Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia",
             "title" : "Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis",
             "pmid" : "12637609"
             "pmid" : "12490682"
         },
         },
         {
         {
             "timestamp" : "2024-05-20T13:33:05Z",
             "timestamp" : "2013-10-09T17:11:02Z",
             "briefDesignDescription" : "IV iron in critical illness",
             "briefDesignDescription" : "Trastuzumab in breast cancer",
             "fulltexturl" : "https://link.springer.com/article/10.1007%2Fs00134-016-4465-6",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa052306",
             "pageid" : 3651,
             "pageid" : 440,
             "pdfurl" : "https://link.springer.com/content/pdf/10.1007/s00134-016-4465-6.pdf",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa052306",
             "trainingLevel" : "Fellow",
             "trainingLevel" : "Resident",
             "citation" : "Litton E, <i>et al</i>. \"Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial\". <i>Intensive Care Med</i>. 2016. 42:1715-1722.",
             "citation" : "Piccart-Gebhart MJ, <i>et al</i>. \"Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer\". <i>The New England Journal of Medicine</i>. 2005. 353(16):1659-72.",
             "subspecialties" : "Critical Care;Hematology",
             "subspecialties" : "Oncology",
             "expansion" : "",
             "expansion" : "Herceptin Adjuvant Trial",
             "statusUsableDate" : "2024-04-30",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "IV iron did not reduce transfusion requirements",
             "briefResultsDescription" : "Trastuzumab improves survival",
             "published" : "2016-11-01",
             "published" : "2005-10-20",
             "pageName" : "IRONMAN",
             "pageName" : "HERA",
             "diseases" : "Anemia;Critical Illness",
             "diseases" : "Breast Cancer",
             "abbreviation" : "IRONMAN",
             "abbreviation" : "HERA",
             "title" : "Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial",
             "title" : "Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer",
             "pmid" : "27686346"
             "pmid" : "16236737"
         },
         },
         {
         {
             "timestamp" : "2017-12-03T22:36:17Z",
             "timestamp" : "2020-10-29T17:37:34Z",
             "briefDesignDescription" : "Oral iron vs. placebo in HFrEF and iron deficiency",
             "briefDesignDescription" : "Edoxaban vs. LMWH in cancer VTE",
             "fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1711948",
             "pageid" : 2941,
             "pageid" : 3509,
             "pdfurl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1711948",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Lewis GD, <i>et al</i>. \"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency\". <i>JAMA</i>. 2017. 317(19):1958-66.",
             "citation" : "Raskob GE, <i>et al</i>. \"Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism\". <i>The New England Journal of Medicine</i>. 2018. 378(7):615-624.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Hematology;Oncology",
             "expansion" : "Iron Repletion Effects on Oxygen Uptake in Heart Failure",
             "expansion" : "",
             "statusUsableDate" : "2017-07-01",
             "statusUsableDate" : "2018-02-01",
             "briefResultsDescription" : "Oral iron not superior to placebo in HFrEF",
             "briefResultsDescription" : "Edoxaban noninferior to dalteparin in cancer VTE",
             "published" : "2017-07-09",
             "published" : "2018-02-15",
             "pageName" : "IRONOUT-HF",
             "pageName" : "Hokusai-VTE",
             "diseases" : "Heart Failure",
             "diseases" : "Venous Thromboembolism;Pulmonary Embolism;Deep Vein Thrombosis",
             "abbreviation" : "IRONOUT-HF",
             "abbreviation" : "",
             "title" : "Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency",
             "title" : "Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism",
             "pmid" : "28510680"
             "pmid" : "29231094"
         },
         },
         {
         {
             "timestamp" : "2019-10-17T17:39:50Z",
             "timestamp" : "2013-08-15T18:50:04Z",
             "briefDesignDescription" : "Ticagrelor vs. prasugrel in ACS",
             "briefDesignDescription" : "Ramipril in patients with high CV risk",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1908973",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM200001203420301",
             "pageid" : 4100,
             "pageid" : 1165,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1908973",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM200001203420301",
             "trainingLevel" : "Resident",
             "trainingLevel" : "intern",
             "citation" : "Schupke S <i>et al</i>. \"Ticagrelor or prasugrel in patients with acute coronary syndromes\". <i>New Engl J Med</i>. 2019. 1-11.",
             "citation" : "Yusuf S, <i>et al</i>. \"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients\". <i>The New England Journal of Medicine</i>. 2000. 342(3):145-153.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology;Neurology",
             "expansion" : "Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5 Trial",
             "expansion" : "Heart Outcomes Prevention Evaluation",
             "statusUsableDate" : "2019-10-17",
             "statusUsableDate" : "2012-03-01",
             "briefResultsDescription" : "Prasugrel superior to ticagrelor in acute coronary syndromes",
             "briefResultsDescription" : "Ramipril reduces death, MI, and stroke",
             "published" : "2019-09-01",
             "published" : "2000-01-20",
             "pageName" : "ISAR-REACT 5",
             "pageName" : "HOPE",
             "diseases" : "Coronary Artery Disease",
             "diseases" : "Coronary Artery Disease;Stroke;Transient Ischemic Attack",
             "abbreviation" : "ISAR-REACT 5",
             "abbreviation" : "HOPE",
             "title" : "Ticagrelor or prasugrel in patients with acute coronary syndromes",
             "title" : "Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients",
             "pmid" : "31475799"
             "pmid" : "10639539"
         },
         },
         {
         {
             "timestamp" : "2021-01-30T20:57:06Z",
             "timestamp" : "2020-12-31T20:42:03Z",
             "briefDesignDescription" : "Triple therapy for 6w vs. 6m after DES",
             "briefDesignDescription" : "Voxelotor in sickle cell disease",
             "fulltexturl" : "http://content.onlinejacc.org/article.aspx?articleID",
             "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/nejmoa1903212",
             "pageid" : 2812,
             "pageid" : 4382,
             "pdfurl" : "https://www.jacc.org/doi/pdf/10.1016/j.jacc.2015.02.050",
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903212",
             "trainingLevel" : "Intern",
             "trainingLevel" : "resident",
             "citation" : "Fiedler KA <i>et al</i>. \"Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation\". <i>J Am Coll Cardiol</i>. 2015. 65(16):1619-30.",
             "citation" : "Vichinsky E, <i>et al</i>. \"A phase 3 randomized trial of voxelotor in sickle cell disease\". <i>The New England Journal of Medicine</i>. 2019. 381(8):509-519.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Hematology",
             "expansion" : "Triple therapy in Patients who Require Oral Anticoagulation After Drug-Eluting Stent Implantation",
             "expansion" : "Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization",
             "statusUsableDate" : "2016-10-01",
             "statusUsableDate" : "2020-12-10",
             "briefResultsDescription" : "Triple therapy for 6 weeks not superior to 6 months in regards to net clinical outcome",
             "briefResultsDescription" : "Voxelotor increases hemoglobin and reduces evidence of hemolysis",
             "published" : "2015-04-28",
             "published" : "2019-08-08",
             "pageName" : "ISAR-TRIPLE",
             "pageName" : "HOPE (Sickle Cell Disease)",
             "diseases" : "Coronary Artery Disease;Atrial Fibrillation",
             "diseases" : "Sickle Cell Disease",
             "abbreviation" : "ISAR-TRIPLE",
             "abbreviation" : "HOPE",
             "title" : "Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation",
             "title" : "A phase 3 randomized trial of voxelotor in sickle cell disease",
             "pmid" : "25908066"
             "pmid" : "31199090"
         },
         },
         {
         {
             "timestamp" : "2021-04-07T17:13:36Z",
             "timestamp" : "2019-09-20T14:01:16Z",
             "briefDesignDescription" : "PCI/CABG vs. medical therapy in stable CAD",
             "briefDesignDescription" : "Statin, BP meds, both, or neither for CVD 1° prevention",
             "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1915922",
             "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1600177",
             "pageid" : 4153,
             "pageid" : 2770,
             "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915922",
             "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1600177",
             "trainingLevel" : "Resident",
             "trainingLevel" : "Resident",
             "citation" : "Maron DJ, <i>et al</i>. \"Initial Invasive or Conservative Strategy for Stable Coronary Disease\". <i>The New England Journal of Medicine</i>. 2020. 382(15):1395-1407.",
             "citation" : "Yusuf S, <i>et al</i>. \"Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease\". <i>The New England Journal of Medicine</i>. 2016. 374(21):2032-2343.",
             "subspecialties" : "Cardiology",
             "subspecialties" : "Cardiology",
             "expansion" : "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches",
            "expansion" : "Heart Outcomes Prevention Evaluation-3",
             "statusUsableDate" : "2021-01-28",
            "statusUsableDate" : "2019-09-19",
             "briefResultsDescription" : "No difference between PCI/CABG and medical therapy in stable CAD with moderate-severe ischemia",
            "briefResultsDescription" : "Statins lower events but BP meds don't.",
             "published" : "2020-04-09",
            "published" : "2016-05-26",
             "pageName" : "ISCHEMIA",
            "pageName" : "HOPE-3",
             "diseases" : "Coronary Artery Disease",
            "diseases" : "Cardiovascular Disease",
             "abbreviation" : "ISCHEMIA",
            "abbreviation" : "HOPE-3",
             "title" : "Initial Invasive or Conservative Strategy for Stable Coronary Disease",
            "title" : "Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease",
            "pmid" : "27039945"
        },
        {
            "timestamp" : "2021-09-09T17:34:24Z",
            "briefDesignDescription" : "Zoledronate vs. placebo in osteoporosis",
            "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa067312",
            "pageid" : 2765,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa067312",
            "trainingLevel" : "Resident",
            "citation" : "Black DM, <i>et al</i>. \"Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis\". <i>The New England Journal of Medicine</i>. 2007. 356(18):1809-22.",
            "subspecialties" : "Endocrinology;Preventive Medicine",
            "expansion" : "Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial",
            "statusUsableDate" : "2021-08-31",
            "briefResultsDescription" : "Annual zoledronate reduces fracture risk in osteoporosis",
            "published" : "2007-05-03",
            "pageName" : "HORIZON-PFT",
            "diseases" : "Osteoporosis",
            "abbreviation" : "HORIZON-PFT",
            "title" : "Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis",
            "pmid" : "17476007"
        },
        {
            "timestamp" : "2024-05-02T17:49:17Z",
            "briefDesignDescription" : "Duration of empiric antibiotics in ↑risk neutropenic fever",
            "fulltexturl" : "https://doi.org/10.1016/S2352-3026(17)30211-9",
            "pageid" : 4119,
            "pdfurl" : null,
            "trainingLevel" : "Fellow",
            "citation" : "Aguilar-Guisado M, <i>et al</i>. \"Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial\". <i>Lancet Haematology</i>. 2017. 4(12):e573-e583.",
            "subspecialties" : "Infectious Disease;Hematology",
            "expansion" : null,
            "statusUsableDate" : "2021-03-15",
            "briefResultsDescription" : "Shorter courses of antibiotics led to fewer days of antibiotics without excess harm",
            "published" : "2017-11-15",
            "pageName" : "How Long",
            "diseases" : "Febrile Neutropenia",
            "abbreviation" : null,
            "title" : "Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial",
            "pmid" : "29153975"
        },
        {
            "timestamp" : "2020-02-06T19:36:49Z",
            "briefDesignDescription" : "Simvastatin in high risk for CVD",
            "fulltexturl" : "http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(02)09327-3",
            "pageid" : 2696,
            "pdfurl" : "",
            "trainingLevel" : "Student",
            "citation" : "Heart Protection Study Collaborative Group Writers. \"MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial\". <i>The Lancet</i>. 2002. 360(9326):7-22.",
            "subspecialties" : "Cardiology",
            "expansion" : "Heart Protection Study Statin Arm",
            "statusUsableDate" : "2020-02-07",
            "briefResultsDescription" : "Simvastatin reduces CVD events and death",
            "published" : "2002-06-06",
            "pageName" : "HPS Statin",
            "diseases" : "Hyperlipidemia;Cardiovascular Disease",
            "abbreviation" : "HPS",
            "title" : "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial",
            "pmid" : "12114036"
        },
        {
            "timestamp" : "2017-12-03T22:35:56Z",
            "briefDesignDescription" : "Niacin in atherosclerotic disease",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300955",
            "pageid" : 2329,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300955",
            "trainingLevel" : "Intern",
            "citation" : "Landray MJ <i>et al</i>. \"Effects of extended-release niacin with laropiprant in high-risk patients\". <i>The New England Journal of Medicine</i>. 2014. 371(3):203-212.",
            "subspecialties" : "Cardiology",
            "expansion" : "Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events",
            "statusUsableDate" : "2015-02-01",
            "briefResultsDescription" : "Niacin is poorly tolerated, doesn't reduce major vascular events",
            "published" : "2014-07-17",
            "pageName" : "HPS2-THRIVE",
            "diseases" : "Coronary Artery Disease;Peripheral Vascular Disease",
            "abbreviation" : "HPS2-THRIVE",
            "title" : "Effects of extended-release niacin with laropiprant in high-risk patients",
            "pmid" : "25014686"
        },
        {
            "timestamp" : "2017-12-03T22:35:58Z",
            "briefDesignDescription" : "Early ART in HIV",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1105243",
            "pageid" : 1010,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1105243",
            "trainingLevel" : "Resident",
            "citation" : "Cohen MS, <i>et al</i>. \"Prevention of HIV-1 Infection with Early Antiretroviral Therapy\". <i>The New England Journal of Medicine</i>. 2011. 365(6):493-505.",
            "subspecialties" : "Infectious Disease",
            "expansion" : "HIV Prevention Trials Network 052 Study",
            "statusUsableDate" : "2012-10-01",
            "briefResultsDescription" : "Reduced morbidity and HIV transmission",
            "published" : "2011-08-11",
            "pageName" : "HPTN 052",
            "diseases" : "HIV",
            "abbreviation" : "HPTN 052",
            "title" : "Prevention of HIV-1 Infection with Early Antiretroviral Therapy",
            "pmid" : "21767103"
        },
        {
            "timestamp" : "2017-12-03T22:35:59Z",
            "briefDesignDescription" : "High sensitivity troponin for acute chest pain",
            "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109714017264",
            "pageid" : 2343,
            "pdfurl" : null,
            "trainingLevel" : "Intern",
            "citation" : "Bandstein N, <i>et al</i>. \"Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction\". <i>Journal of the American College of Cardiology</i>. 2014. 63(23):2569-2578.",
            "subspecialties" : "Emergency Medicine;Cardiology",
            "expansion" : null,
            "statusUsableDate" : "2015-03-01",
            "briefResultsDescription" : "HS troponin-T is associated with high NPV for MI at 30 days",
            "published" : "2014-06-17",
            "pageName" : "HS troponin-T to rule out MI",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : null,
            "title" : "Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction",
            "pmid" : "24694529"
        },
        {
            "timestamp" : "2017-12-03T22:36:04Z",
            "briefDesignDescription" : "Perinatal vitamins to prevent neural tube defects",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJM199212243272602",
            "pageid" : 2142,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJM199212243272602",
            "trainingLevel" : "Student",
            "citation" : "Czeizel AE and Dudas I. \"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation\". <i>The New England Journal of Medicine</i>. 1992. 327(26):1832-1835.",
            "subspecialties" : "Obstetrics;Preventive Medicine",
            "expansion" : null,
            "statusUsableDate" : "2014-09-01",
            "briefResultsDescription" : "Perinatal vitamins reduce neural tube defects",
            "published" : "1992-12-24",
            "pageName" : "Hungarian Prenatal Vitamin Trial",
            "diseases" : "Neural Tube Defects",
            "abbreviation" : null,
            "title" : "Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation",
            "pmid" : "1307234"
        },
        {
            "timestamp" : "2023-11-22T21:12:44Z",
            "briefDesignDescription" : "Hydrocortisone, Vit C, and thiamine in sepsis",
            "fulltexturl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext",
            "pageid" : 2946,
            "pdfurl" : "http://journal.chestnet.org/article/S0012-3692(16)62564-3/pdf",
            "trainingLevel" : "Resident",
            "citation" : "Marik PE, <i>et al</i>. \"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study\". <i>Chest</i>. 2017. 151(6):1229-1238.",
            "subspecialties" : "Critical Care;Infectious Disease;Pulmonology",
            "expansion" : "",
            "statusUsableDate" : "2018-08-13",
            "briefResultsDescription" : "Pilot study with impressive findings, low-quality data",
            "published" : "2017-06-01",
            "pageName" : "Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock",
            "diseases" : "Sepsis;Shock",
            "abbreviation" : "",
            "title" : "Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study",
            "pmid" : "27940189"
        },
        {
            "timestamp" : "2018-02-08T17:14:46Z",
            "briefDesignDescription" : "Hydrocortisone in severe sepsis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMsa1410639",
            "pageid" : 2860,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMsa1410639",
            "trainingLevel" : "Resident",
            "citation" : "Keh D, <i>et al</i>. \"Effect of hydrocortisone on development of shock among patients with severe sepsis\". <i>Journal of the American Medical Association</i>. 2016. 316(17):1775-1785.",
            "subspecialties" : "Critical Care",
            "expansion" : "",
            "statusUsableDate" : "2016-11-01",
            "briefResultsDescription" : "Hydrocortisone not superior to placebo in severe sepsis",
            "published" : "2016-10-03",
            "pageName" : "HYPRESS",
            "diseases" : "Sepsis",
            "abbreviation" : "HYPRESS",
            "title" : "Effect of hydrocortisone on development of shock among patients with severe sepsis",
            "pmid" : "27695824"
        },
        {
            "timestamp" : "2018-01-11T18:14:28Z",
            "briefDesignDescription" : "Elderly HTN treatment",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0801369",
            "pageid" : 2349,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0801369",
            "trainingLevel" : "Intern",
            "citation" : "Beckett NS, <i>et al</i>. \"Treatment of hypertension in patients 80 years of age or older\". <i>The New England Journal of Medicine</i>. 2008. 358(18):1887-1898.",
            "subspecialties" : "Nephrology;Cardiology;Geriatrics",
            "expansion" : "Hypertension in the Very Elderly Trial",
            "statusUsableDate" : "2015-04-01",
            "briefResultsDescription" : "Trend towards reduction in stroke with treatment (P",
            "published" : "2008-05-01",
            "pageName" : "HYVET",
            "diseases" : "Hypertension",
            "abbreviation" : "HYVET",
            "title" : "Treatment of hypertension in patients 80 years of age or older",
            "pmid" : "18378519"
        },
        {
            "timestamp" : "2017-09-24T13:54:35Z",
            "briefDesignDescription" : "IABP in MI and cardiogenic shock",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208410",
            "pageid" : 1065,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208410",
            "trainingLevel" : "Fellow",
            "citation" : "Thiele H, <i>et al</i>. \"Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock\". <i>The New England Journal of Medicine</i>. 2012. 367(14):1287-1296.",
            "subspecialties" : "Cardiology;Critical Care",
            "expansion" : "Intraaortic Balloon Pump in Cardiogenic Shock II",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "IABP did not reduce mortality at 30 days",
            "published" : "2012-10-10",
            "pageName" : "IABP-SHOCK II",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction;Shock",
            "abbreviation" : "IABP-SHOCK II",
            "title" : "Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock",
            "pmid" : "22920912"
        },
        {
            "timestamp" : "2019-05-23T17:29:10Z",
            "briefDesignDescription" : "Adjuvant cisplatin in resected NSCLC",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa031644",
            "pageid" : 2503,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa031644",
            "trainingLevel" : "Fellow",
            "citation" : "Arriagada R, <i>et al</i>. \"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer\". <i>The New England Journal of Medicine</i>. 2004. 350(4):351-360.",
            "subspecialties" : "Oncology",
            "expansion" : "International Adjuvant Lung Cancer Trial",
            "statusUsableDate" : "2019-05-23",
            "briefResultsDescription" : "Adjuvant cisplatin improves 5-year OS in resected NSCLC",
            "published" : "2004-01-22",
            "pageName" : "IALT",
            "diseases" : "Lung Cancer",
            "abbreviation" : "IALT",
            "title" : "Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer",
            "pmid" : "14736927"
        },
        {
            "timestamp" : "2021-11-04T17:33:05Z",
            "briefDesignDescription" : "Second-line ibrutinib in WM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1501548",
            "pageid" : 2660,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1501548",
            "trainingLevel" : "Fellow",
            "citation" : "Treon SP, <i>et al</i>. \"Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia\". <i>The New England Journal of Medicine</i>. 2015. 372(15):1430-1440.",
            "subspecialties" : "Hematology",
            "expansion" : null,
            "statusUsableDate" : "2015-12-01",
            "briefResultsDescription" : "Ibrutinib is safe and effective in previously treated WM",
            "published" : "2015-04-09",
            "pageName" : "Ibrutinib in Waldenstrom macroglobulinemia",
            "diseases" : "Lymphoma;Waldenström Macroglobulinemia",
            "abbreviation" : null,
            "title" : "Ibrutinib in Previously Treated Waldenstrom Macroglobulinemia",
            "pmid" : "25853747"
        },
        {
            "timestamp" : "2020-02-10T07:03:58Z",
            "briefDesignDescription" : "Ibrutinib-rituximab vs. FCR in untreated CLL",
            "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1817073",
            "pageid" : 4175,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1817073",
            "trainingLevel" : "Fellow",
            "citation" : "Shanafelt TD, <i>et al</i>. \"Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia\". <i>The New England Journal of Medicine</i>. 2019. 381(5):432-43.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "",
            "statusUsableDate" : "2020-02-09",
            "briefResultsDescription" : "IR improved survival over FCR in untreated CLL",
            "published" : "2019-08-01",
            "pageName" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
            "diseases" : "Chronic Lymphocytic Leukemia;Small Lymphocytic Lymphoma",
            "abbreviation" : "E1912",
            "title" : "Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia",
            "pmid" : "31365801"
        },
        {
            "timestamp" : "2018-10-16T05:02:38Z",
            "briefDesignDescription" : "Colchicine in the first episode of acute pericarditis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1208536",
            "pageid" : 1729,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1208536",
            "trainingLevel" : "Intern",
            "citation" : "Imazio M, <i>et al</i>. \"A Randomized Trial of Colchicine for Acute Pericarditis\". <i>The New England Journal of Medicine</i>. 2013. 369(16):1522-1528.",
            "subspecialties" : "Cardiology",
            "expansion" : "Evaluation of additive benefit of colchicine to conventional therapy in acute pericarditis",
            "statusUsableDate" : "2014-01-01",
            "briefResultsDescription" : "Colchicine reduces incessant or recurrent acute pericarditis when used in first episode",
            "published" : "2013-10-17",
            "pageName" : "ICAP",
            "diseases" : "Pericarditis",
            "abbreviation" : "ICAP",
            "title" : "A Randomized Trial of Colchicine for Acute Pericarditis",
            "pmid" : "23992557"
        },
        {
            "timestamp" : "2017-12-03T22:36:07Z",
            "briefDesignDescription" : "Early vs. late dialysis in CKD",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1000552",
            "pageid" : 1020,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1000552",
            "trainingLevel" : "Resident",
            "citation" : "Cooper BA, <i>et al</i>. \"A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis\". <i>The New England Journal of Medicine</i>. 2010. 363(7):609-619.",
            "subspecialties" : "Nephrology",
            "expansion" : "Initiating Dialysis Early and Late",
            "statusUsableDate" : "2012-10-01",
            "briefResultsDescription" : "No difference in survival or clinical outcomes",
            "published" : "2010-08-12",
            "pageName" : "IDEAL",
            "diseases" : "Chronic Kidney Disease",
            "abbreviation" : "IDEAL",
            "title" : "A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis",
            "pmid" : "20581422"
        },
        {
            "timestamp" : "2019-03-27T18:27:05Z",
            "briefDesignDescription" : "Early vs. delayed RRT in septic shock",
            "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1803213",
            "pageid" : 3746,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1803213",
            "trainingLevel" : "Resident",
            "citation" : "Barbar SD, <i>et al</i>. \"Timing of renal-replacement therapy in patients with acute kidney injury and sepsis\". <i>The New England Journal of Medicine</i>. 2018. 379(15):1431-1442.",
            "subspecialties" : "Critical Care;Nephrology",
            "expansion" : "Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit",
            "statusUsableDate" : "2019-03-27",
            "briefResultsDescription" : "No benefit from early initiated RRT in septic shock",
            "published" : "2018-10-11",
            "pageName" : "IDEAL-ICU",
            "diseases" : "Acute Kidney Injury;Septic Shock",
            "abbreviation" : "IDEAL-ICU",
            "title" : "Timing of renal-replacement therapy in patients with acute kidney injury and sepsis",
            "pmid" : "30304656"
        },
        {
            "timestamp" : "2017-12-03T22:36:08Z",
            "briefDesignDescription" : "ARBs in diabetic nephropathy",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011303",
            "pageid" : 2670,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011303",
            "trainingLevel" : "Resident",
            "citation" : "Lewis EJ, <i>et al</i>. \"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2001. 345(12):851-860.",
            "subspecialties" : "Nephrology;Endocrinology",
            "expansion" : "Irbesartan Diabetic Nephropathy Trial",
            "statusUsableDate" : "2016-01-01",
            "briefResultsDescription" : "ARBs prevent progression of T2DM nephropathy",
            "published" : "2001-09-20",
            "pageName" : "IDNT",
            "diseases" : "Diabetic Nephropathy;Diabetes Mellitus",
            "abbreviation" : "IDNT",
            "title" : "Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes",
            "pmid" : "11565517"
        },
        {
            "timestamp" : "2017-12-03T22:36:10Z",
            "briefDesignDescription" : "iFR vs. FFR for PCI",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1616540",
            "pageid" : 2926,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1616540",
            "trainingLevel" : "Resident",
            "citation" : "Gotberg M, <i>et al</i>. \"Spontaneous wave-free ratio versus fractional flow reserve to guide PCI\". <i>The New England Journal of Medicine</i>. 2017. 376(19):1813-1823.",
            "subspecialties" : "Cardiology",
            "expansion" : "Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome",
            "statusUsableDate" : "2017-05-01",
            "briefResultsDescription" : "iFR noninferior to FFR for PCI",
            "published" : "2017-05-11",
            "pageName" : "IFR-SWEDEHEART",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "iFR-SWEDEHEART",
            "title" : "Spontaneous wave-free ratio versus fractional flow reserve to guide PCI",
            "pmid" : "28317438"
        },
        {
            "timestamp" : "2017-12-14T19:46:19Z",
            "briefDesignDescription" : "Ezetimibe+simvastatin after ACS",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1410489",
            "pageid" : 2369,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489",
            "trainingLevel" : "Intern",
            "citation" : "Cannon CP, <i>et al</i>. \"Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes\". <i>The New England Journal of Medicine</i>. 2015. 375(25):2387-2397.",
            "subspecialties" : "Cardiology",
            "expansion" : "IMProved Reduction of Outcomes: Vytorin Efficacy International Trial",
            "statusUsableDate" : "2015-06-01",
            "briefResultsDescription" : "Ezetimibe improves CV outcomes when added to statin",
            "published" : "2015-06-18",
            "pageName" : "IMPROVE-IT",
            "diseases" : "Hyperlipidemia;Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : "IMPROVE-IT",
            "title" : "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes",
            "pmid" : "26039521"
        },
        {
            "timestamp" : "2018-03-30T14:11:39Z",
            "briefDesignDescription" : "Nintedanib in IPF",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1402584",
            "pageid" : 2934,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1402584",
            "trainingLevel" : "Resident",
            "citation" : "Richeldi L, <i>et al</i>. \"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis\". <i>The New England Journal of Medicine</i>. 2014. 370(22):2071-2082.",
            "subspecialties" : "Pulmonology",
            "expansion" : "",
            "statusUsableDate" : "2018-03-30",
            "briefResultsDescription" : "Nintedanib slows progression of IPF",
            "published" : "2014-05-29",
            "pageName" : "INPULSIS Trials",
            "diseases" : "Idiopathic Pulmonary Fibrosis",
            "abbreviation" : "INPULSIS I and II",
            "title" : "Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis",
            "pmid" : "24836310"
        },
        {
            "timestamp" : "2017-12-03T22:36:12Z",
            "briefDesignDescription" : "Early vs. delayed ART in HIV",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1506816",
            "pageid" : 2468,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1506816",
            "trainingLevel" : "Student",
            "citation" : "INSIGHT START Writers. \"Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection\". <i>The New England Journal of Medicine</i>. 2015. 373(9):795-807.",
            "subspecialties" : "Infectious Disease",
            "expansion" : null,
            "statusUsableDate" : "2016-01-01",
            "briefResultsDescription" : "Less complications with early ART",
            "published" : "2015-08-27",
            "pageName" : "INSIGHT START",
            "diseases" : "HIV",
            "abbreviation" : "START",
            "title" : "Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection",
            "pmid" : "26192873"
        },
        {
            "timestamp" : "2017-12-03T22:36:14Z",
            "briefDesignDescription" : "ART in primary HIV prevention",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1011205",
            "pageid" : 1100,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1011205",
            "trainingLevel" : "intern",
            "citation" : "Grant RM, <i>et al</i>. \"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men\". <i>The New England Journal of Medicine</i>. 2010. 363(27):2587-2599.",
            "subspecialties" : "Infectious Disease;Preventive Medicine",
            "expansion" : "Iniciativa Profilaxis Pre Exposicion (\"Preexposure Prophylaxis Initiative\")",
            "statusUsableDate" : "2013-02-01",
            "briefResultsDescription" : "ART reduces tranmission of HIV among MSM",
            "published" : "2010-12-30",
            "pageName" : "IPrEx",
            "diseases" : "HIV",
            "abbreviation" : "iPrEx",
            "title" : "Preexposure chemoprophylaxis for HIV prevention in men who have sex with men",
            "pmid" : "21091279"
        },
        {
            "timestamp" : "2017-12-03T22:36:15Z",
            "briefDesignDescription" : "Imatinib vs. IFNα/cytarabine in CML",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa022457",
            "pageid" : 1076,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa022457",
            "trainingLevel" : "Student",
            "citation" : "O'Brien SG, <i>et al</i>. \"Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia\". <i>The New England Journal of Medicine</i>. 2003. 384(11):994-1004.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "International Randomized Study of Interferon and STI571",
            "statusUsableDate" : "2012-11-01",
            "briefResultsDescription" : "Imatinib delays disease progression",
            "published" : "2003-03-13",
            "pageName" : "IRIS",
            "diseases" : "Chronic Myeloid Leukemia;Myeloproliferative Neoplasms",
            "abbreviation" : "IRIS",
            "title" : "Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia",
            "pmid" : "12637609"
        },
        {
            "timestamp" : "2024-05-20T13:33:05Z",
            "briefDesignDescription" : "IV iron in critical illness",
            "fulltexturl" : "https://link.springer.com/article/10.1007%2Fs00134-016-4465-6",
            "pageid" : 3651,
            "pdfurl" : "https://link.springer.com/content/pdf/10.1007/s00134-016-4465-6.pdf",
            "trainingLevel" : "Fellow",
            "citation" : "Litton E, <i>et al</i>. \"Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial\". <i>Intensive Care Med</i>. 2016. 42:1715-1722.",
            "subspecialties" : "Critical Care;Hematology",
            "expansion" : "",
            "statusUsableDate" : "2024-04-30",
            "briefResultsDescription" : "IV iron did not reduce transfusion requirements",
            "published" : "2016-11-01",
            "pageName" : "IRONMAN",
            "diseases" : "Anemia;Critical Illness",
            "abbreviation" : "IRONMAN",
            "title" : "Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial",
            "pmid" : "27686346"
        },
        {
            "timestamp" : "2017-12-03T22:36:17Z",
            "briefDesignDescription" : "Oral iron vs. placebo in HFrEF and iron deficiency",
            "fulltexturl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
            "pageid" : 2941,
            "pdfurl" : "http://jamanetwork.com/journals/jama/article-abstract/2626574",
            "trainingLevel" : "Resident",
            "citation" : "Lewis GD, <i>et al</i>. \"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency\". <i>JAMA</i>. 2017. 317(19):1958-66.",
            "subspecialties" : "Cardiology",
            "expansion" : "Iron Repletion Effects on Oxygen Uptake in Heart Failure",
            "statusUsableDate" : "2017-07-01",
            "briefResultsDescription" : "Oral iron not superior to placebo in HFrEF",
            "published" : "2017-07-09",
            "pageName" : "IRONOUT-HF",
            "diseases" : "Heart Failure",
            "abbreviation" : "IRONOUT-HF",
            "title" : "Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency",
            "pmid" : "28510680"
        },
        {
            "timestamp" : "2019-10-17T17:39:50Z",
            "briefDesignDescription" : "Ticagrelor vs. prasugrel in ACS",
            "fulltexturl" : "https://www.nejm.org/doi/full/10.1056/NEJMoa1908973",
            "pageid" : 4100,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1908973",
            "trainingLevel" : "Resident",
            "citation" : "Schupke S <i>et al</i>. \"Ticagrelor or prasugrel in patients with acute coronary syndromes\". <i>New Engl J Med</i>. 2019. 1-11.",
            "subspecialties" : "Cardiology",
            "expansion" : "Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5 Trial",
            "statusUsableDate" : "2019-10-17",
            "briefResultsDescription" : "Prasugrel superior to ticagrelor in acute coronary syndromes",
            "published" : "2019-09-01",
            "pageName" : "ISAR-REACT 5",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "ISAR-REACT 5",
            "title" : "Ticagrelor or prasugrel in patients with acute coronary syndromes",
            "pmid" : "31475799"
        },
        {
            "timestamp" : "2021-01-30T20:57:06Z",
            "briefDesignDescription" : "Triple therapy for 6w vs. 6m after DES",
            "fulltexturl" : "http://content.onlinejacc.org/article.aspx?articleID",
            "pageid" : 2812,
            "pdfurl" : "https://www.jacc.org/doi/pdf/10.1016/j.jacc.2015.02.050",
            "trainingLevel" : "Intern",
            "citation" : "Fiedler KA <i>et al</i>. \"Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation\". <i>J Am Coll Cardiol</i>. 2015. 65(16):1619-30.",
            "subspecialties" : "Cardiology",
            "expansion" : "Triple therapy in Patients who Require Oral Anticoagulation After Drug-Eluting Stent Implantation",
            "statusUsableDate" : "2016-10-01",
            "briefResultsDescription" : "Triple therapy for 6 weeks not superior to 6 months in regards to net clinical outcome",
            "published" : "2015-04-28",
            "pageName" : "ISAR-TRIPLE",
            "diseases" : "Coronary Artery Disease;Atrial Fibrillation",
            "abbreviation" : "ISAR-TRIPLE",
            "title" : "Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation",
            "pmid" : "25908066"
        },
        {
            "timestamp" : "2021-04-07T17:13:36Z",
            "briefDesignDescription" : "PCI/CABG vs. medical therapy in stable CAD",
            "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1915922",
            "pageid" : 4153,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1915922",
            "trainingLevel" : "Resident",
            "citation" : "Maron DJ, <i>et al</i>. \"Initial Invasive or Conservative Strategy for Stable Coronary Disease\". <i>The New England Journal of Medicine</i>. 2020. 382(15):1395-1407.",
            "subspecialties" : "Cardiology",
             "expansion" : "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches",
             "statusUsableDate" : "2021-01-28",
             "briefResultsDescription" : "No difference between PCI/CABG and medical therapy in stable CAD with moderate-severe ischemia",
             "published" : "2020-04-09",
             "pageName" : "ISCHEMIA",
             "diseases" : "Coronary Artery Disease",
             "abbreviation" : "ISCHEMIA",
             "title" : "Initial Invasive or Conservative Strategy for Stable Coronary Disease",
             "pmid" : "32227755"
             "pmid" : "32227755"
        },
        {
            "timestamp" : "2017-12-20T19:04:02Z",
            "briefDesignDescription" : "Aspirin ± streptokinase in acute MI",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(88)92833-4/abstract",
            "pageid" : 133,
            "pdfurl" : "",
            "trainingLevel" : "Resident",
            "citation" : "ISIS-2 Collaborative Group. \"Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17187 Cases of Suspected Acute Myocardial Infarction\". <i>The Lancet</i>. 1988. 332(8607):349-360.",
            "subspecialties" : "Cardiology",
            "expansion" : "Second International Study of Infarct Survival",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Mortality benefit of aspirin within 24 hours of acute MI",
            "published" : "1988-08-13",
            "pageName" : "ISIS-2",
            "diseases" : "Acute Coronary Syndrome;Myocardial Infarction",
            "abbreviation" : "ISIS-2",
            "title" : "Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17187 Cases of Suspected Acute Myocardial Infarction",
            "pmid" : "2899772"
        },
        {
            "timestamp" : "2016-03-07T04:46:48Z",
            "briefDesignDescription" : "Aspirin in acute ischemic stroke",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(97)04011-7/fulltext",
            "pageid" : 132,
            "pdfurl" : "http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673697040117.pdf",
            "trainingLevel" : "Intern",
            "citation" : "IST Collaborative Group. \"The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke\". <i>The Lancet</i>. 1997. 349(9065):1569-1581.",
            "subspecialties" : "Neurology",
            "expansion" : "International Stroke Trial",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Mortality benefit with aspirin",
            "published" : "1997-05-31",
            "pageName" : "IST",
            "diseases" : "Stroke",
            "abbreviation" : "IST",
            "title" : "The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke",
            "pmid" : "9174558"
        },
        {
            "timestamp" : "2017-12-03T22:36:21Z",
            "briefDesignDescription" : "Rosuvastatin for primary CV prevention",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0807646",
            "pageid" : 445,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0807646",
            "trainingLevel" : "resident",
            "citation" : "Ridker PM, <i>et al</i>. \"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein\". <i>The New England Journal of Medicine</i>. 2008. 359(21):2195-2207.",
            "subspecialties" : "Cardiology;Preventive Medicine",
            "expansion" : "Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin",
            "statusUsableDate" : "2012-06-01",
            "briefResultsDescription" : "Rosuvastatin delays major CV events",
            "published" : "2008-11-20",
            "pageName" : "JUPITER",
            "diseases" : "Hyperlipidemia;Coronary Artery Disease;Stroke;Transient Ischemic Attack",
            "abbreviation" : "JUPITER",
            "title" : "Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein",
            "pmid" : "18997196"
        },
        {
            "timestamp" : "2017-12-03T22:36:23Z",
            "briefDesignDescription" : "Pembrolizumab vs. chemotherapy in NSCLC",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1606774",
            "pageid" : 2846,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1606774",
            "trainingLevel" : "Resident",
            "citation" : "Reck M, <i>et al</i>. \"Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer\". <i>The New England Journal of Medicine</i>. 2016. 375(19):1824-1833.",
            "subspecialties" : "Oncology",
            "expansion" : "",
            "statusUsableDate" : "2016-11-01",
            "briefResultsDescription" : "Pembrolizumab improves survival in advanced NSCLC over chemotherapy",
            "published" : "2016-11-10",
            "pageName" : "KEYNOTE-024",
            "diseases" : "Lung Cancer",
            "abbreviation" : "KEYNOTE-024",
            "title" : "Pembrolizumab versus chemotherapy for PD-L1–positive non-small-cell lung cancer",
            "pmid" : "27718847"
        },
        {
            "timestamp" : "2023-11-22T21:21:50Z",
            "briefDesignDescription" : "Liraglutide and CVD endpoints in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1603827",
            "pageid" : 2803,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1603827",
            "trainingLevel" : "Resident",
            "citation" : "Marso SP, <i>et al</i>. \"Liraglutide and cardiovascular outcomes in type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2016. 375(4):311-322.",
            "subspecialties" : "Cardiology;Endocrinology",
            "expansion" : "Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results",
            "statusUsableDate" : "2016-09-01",
            "briefResultsDescription" : "Liraglutide reduces CV mortality in T2DM",
            "published" : "2016-06-28",
            "pageName" : "LEADER",
            "diseases" : "Diabetes Mellitus;Cardiovascular Disease",
            "abbreviation" : "LEADER",
            "title" : "Liraglutide and cardiovascular outcomes in type 2 diabetes",
            "pmid" : "27295427"
        },
        {
            "timestamp" : "2018-10-25T17:05:24Z",
            "briefDesignDescription" : "Lenalidomide/dexamethasone in smoldering MM",
            "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa1300439",
            "pageid" : 3706,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1300439",
            "trainingLevel" : "Fellow",
            "citation" : "Mateos MV, <i>et al</i>. \"Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma\". <i>The New England Journal of Medicine</i>. 2013. 369(5):438-47.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "",
            "statusUsableDate" : "2018-10-25",
            "briefResultsDescription" : "In flawed trial, LenDex improved OS compared to observation",
            "published" : "2013-08-01",
            "pageName" : "LenDex in High-Risk Smoldering Myeloma",
            "diseases" : "Multiple Myeloma",
            "abbreviation" : "",
            "title" : "Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma",
            "pmid" : "23902483"
        },
        {
            "timestamp" : "2017-12-03T22:36:26Z",
            "briefDesignDescription" : "Epidural steroids in spinal stenosis",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1313265",
            "pageid" : 1883,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1313265",
            "trainingLevel" : "Resident",
            "citation" : "Friedly JL, <i>et al</i>. \"A randomized trial of epidural glucocorticoid injections for spinal stenosis\". <i>The New England Journal of Medicine</i>. 2014. 371(1):11-21.",
            "subspecialties" : "Pain Medicine;Physical Medicine and Rehabilitation;Radiology",
            "expansion" : "Lumbar Epidural Steroid Injections for Spinal Stenosis",
            "statusUsableDate" : "2014-07-01",
            "briefResultsDescription" : "Epidural steroids don't improve pain or disability at six weeks",
            "published" : "2014-07-03",
            "pageName" : "LESS",
            "diseases" : "Spinal Stenosis",
            "abbreviation" : "LESS",
            "title" : "A randomized trial of epidural glucocorticoid injections for spinal stenosis",
            "pmid" : "24988555"
        },
        {
            "timestamp" : "2017-01-19T20:18:41Z",
            "briefDesignDescription" : "Intensive glycemic therapy in the surgical ICU",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa011300",
            "pageid" : 139,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa011300",
            "trainingLevel" : "Resident",
            "citation" : "Van den Berghe G, <i>et al</i>. \"Intensive Insulin Therapy in Critically Ill Patients\". <i>The New England Journal of Medicine</i>. 2001. 345(19):1359-1367.",
            "subspecialties" : "Critical Care;Endocrinology",
            "expansion" : "",
            "statusUsableDate" : "2012-03-01",
            "briefResultsDescription" : "Intensive glycemic control reduces mortality",
            "published" : "2001-11-08",
            "pageName" : "Leuven Surgical Trial",
            "diseases" : "Stress Hyperglycemia",
            "abbreviation" : "Leuven Surgical Trial",
            "title" : "Intensive Insulin Therapy in Critically Ill Patients",
            "pmid" : "11794168"
        },
        {
            "timestamp" : "2024-04-02T17:35:36Z",
            "briefDesignDescription" : "ARB vs. B-blocker in HTN with LVH",
            "fulltexturl" : "http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)08089-3/abstract",
            "pageid" : 2439,
            "pdfurl" : "http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(02)08089-3.pdf",
            "trainingLevel" : "Student",
            "citation" : "Dahlof B, <i>et al</i>. \"Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)\". <i>The Lancet</i>. 2002. 359:995-1003.",
            "subspecialties" : "Nephrology",
            "expansion" : "Cardiovvascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol",
            "statusUsableDate" : "2024-03-29",
            "briefResultsDescription" : "Losartan lowers stroke, MI, or CVD mortality vs. atenolol in HTN with LVH",
            "published" : "2002-03-23",
            "pageName" : "LIFE",
            "diseases" : "Hypertension;Cardiovascular Disease;Stroke",
            "abbreviation" : "LIFE",
            "title" : "Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)",
            "pmid" : "11937178"
        },
        {
            "timestamp" : "2017-12-03T22:36:27Z",
            "briefDesignDescription" : "ATRA-ATO vs. ATRA-chemotherapy in APL",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1300874",
            "pageid" : 2285,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1300874",
            "trainingLevel" : "Fellow",
            "citation" : "Lo-Coco F, <i>et al</i>. \"Retinoic acid and arsenic trioxide for acute promyelocytic leukemia\". <i>The New England Journal of Medicine</i>. 2013. 369(2):111-21.",
            "subspecialties" : "Hematology;Oncology",
            "expansion" : "",
            "statusUsableDate" : "2014-12-01",
            "briefResultsDescription" : "ATRA-ATO is noninferior, possibly superior to ATRA-chemotherapy in APL",
            "published" : "2013-07-11",
            "pageName" : "Lo-Coco 2013",
            "diseases" : "Leukemia",
            "abbreviation" : "",
            "title" : "Retinoic acid and arsenic trioxide for acute promyelocytic leukemia",
            "pmid" : "23841729"
        },
        {
            "timestamp" : "2021-02-18T20:36:25Z",
            "briefDesignDescription" : "Colchicine for stable CAD",
            "fulltexturl" : "http://www.sciencedirect.com/science/article/pii/S0735109712054782",
            "pageid" : 1583,
            "pdfurl" : null,
            "trainingLevel" : "Resident",
            "citation" : "Nidorf SM, <i>et al</i>. \"Low-dose colchicine for secondary prevention of cardiovascular disease\". <i>Journal of the American College of Cardiology</i>. 2013. 61(4):404-410.",
            "subspecialties" : "Cardiology",
            "expansion" : "Low-Dose Colchicine",
            "statusUsableDate" : "2013-08-01",
            "briefResultsDescription" : "Colcicine may reduce complications in stable CAD",
            "published" : "2013-01-29",
            "pageName" : "LoDoCo",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "LoDoCo",
            "title" : "Low-dose colchicine for secondary prevention of cardiovascular disease",
            "pmid" : "23265346"
        },
        {
            "timestamp" : "2024-08-08T17:36:48Z",
            "briefDesignDescription" : "Colchicine in stable CAD",
            "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2021372",
            "pageid" : 4359,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021372",
            "trainingLevel" : "Resident",
            "citation" : "Nidorf SM, <i>et al</i>. \"Colchicine in patients with chronic coronary disease\". <i>The New England Journal of Medicine</i>. 2020. 383(19):1838-1847.",
            "subspecialties" : "Cardiology",
            "expansion" : "Low Dose Colchicine 2",
            "statusUsableDate" : "2021-02-18",
            "briefResultsDescription" : "Colchicine with fewer CV events",
            "published" : "2020-11-05",
            "pageName" : "LoDoCo2",
            "diseases" : "Coronary Artery Disease",
            "abbreviation" : "LoDoCo2",
            "title" : "Colchicine in patients with chronic coronary disease",
            "pmid" : "32865380"
        },
        {
            "timestamp" : "2017-12-03T22:37:21Z",
            "briefDesignDescription" : "Weight loss and exercise in T2DM",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa1212914",
            "pageid" : 1546,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa1212914",
            "trainingLevel" : "Intern",
            "citation" : "Wing RR, <i>et al</i>. \"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes\". <i>The New England Journal of Medicine</i>. 2013. 369(2):145-154.",
            "subspecialties" : "Endocrinology;Cardiology",
            "expansion" : "Look Action for HEAlth in Diabetes",
            "statusUsableDate" : "2013-09-01",
            "briefResultsDescription" : "No reduction of CVD with weight loss and exercise in T2DM",
            "published" : "2013-07-11",
            "pageName" : "Look AHEAD",
            "diseases" : "Diabetes Mellitus;Cardiovascular Disease",
            "abbreviation" : "Look AHEAD",
            "title" : "Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes",
            "pmid" : "23796131"
        },
        {
            "timestamp" : "2023-11-09T19:05:49Z",
            "briefDesignDescription" : "Vitamin C in sepsis",
            "fulltexturl" : "https://www.nejm.org/doi/10.1056/NEJMoa2200644",
            "pageid" : 5147,
            "pdfurl" : "https://www.nejm.org/doi/pdf/10.1056/NEJMoa2200644",
            "trainingLevel" : "Resident",
            "citation" : "Lamontagne, F, <i>et al</i>. \"Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit\". <i>New England Journal of Medicine</i>. 2022. 386(25):2387-2398.",
            "subspecialties" : "Critical Care;Infectious Disease",
            "expansion" : "Lessening Organ Dysfunction with Vitamin C",
            "statusUsableDate" : "2023-10-28",
            "briefResultsDescription" : "Vitamin C associated with greater risk of poor ICU outcomes",
            "published" : "2022-06-23",
            "pageName" : "LOVIT",
            "diseases" : "Septic Shock",
            "abbreviation" : "LOVIT",
            "title" : "Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit",
            "pmid" : "35704292"
        },
        {
            "timestamp" : "2017-12-03T22:37:23Z",
            "briefDesignDescription" : "CRT in HFrEF with QRS ≥130 msec and mild symptoms",
            "fulltexturl" : "http://www.nejm.org/doi/full/10.1056/NEJMoa0906431",
            "pageid" : 1780,
            "pdfurl" : "http://www.nejm.org/doi/pdf/10.1056/NEJMoa0906431",
            "trainingLevel" : "Resident",
            "citation" : "Moss AJ, <i>et al</i>. \"Cardiac-resynchronization therapy for the prevention of heart-failure events\". <i>The New England Journal of Medicine</i>. 2009. 361(14):1329-1338.",
            "subspecialties" : "Cardiology",
            "expansion" : "Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy",
            "statusUsableDate" : "2014-04-01",
            "briefResultsDescription" : "CRT reduces mortality or HF complications in mildly symptomatic HFrEF with prolonged QRS",
            "published" : "2009-10-01",
            "pageName" : "MADIT-CRT",
            "diseases" : "Heart Failure",
            "abbreviation" : "MADIT-CRT",
            "title" : "Cardiac-resynchronization therapy for the prevention of heart-failure events",
            "pmid" : "19723701"
         },
         },
         {
         {
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