WikiJournalClub talk:High-priority articles

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Article Dugout


  • CONFIRM-HF[1] - Iron for HF with iron deficiency

Classic Articles

  • 2010 TALC: Tiotropum in addition to inhaled corticosteroids for asthma. [2]
  • 2005 APPROVe: Rofecoxib (Vioxx) in colorectal cancer, increased MIs [3]
  • 2003 CALGB 9741: Dose-dense AC in breast cancer [4]
  • 2002 MIRACLE: Cardiac resynchronization in HF [5]
  • 2000 Daily Sedation Holidays in ICU: Daily Sedation Holidays in Vented Patients in the ICU [6]
  • 2000 VIGOR: Rofecoxib (Vioxx) in RA, notable for selective exclusion of MI data [7]
  • 1998 Autism and the MMR vaccine in children: The infamous (now retracted) Lancet article reportedly linking vaccinations with the MMR vaccine
  • 1998 SCCOPE: Duration of corticosteroids in COPD exacerbations [8]
  • 1997 ESSENCE: LMWH vs. UFH in UA [9]
  • 1993 CSG: ACE inhibitors in preventing diabetic nephropathy [10]

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Recommendations from L. Lanthier
The only problem that I see is that recent major trial are not all there (those in 2010-2012). Here is a list of studies that changes practice/treatment in the last 2-3 years :
  • RAFT (N Engl J Med 2010 ; 363 : 2385-95)
  • STICH (N Engl J Med 2011;364:1607-16)
  • ARISTOTLE (N Engl J Med 2011;365:981-92).
  • ROCKET-AF (N Engl J Med 2011;365:883-91).
  • Azithromycin for COPD (N Engl J Med 2011;365:689-98).
  • Outpatient treatment of PE (Lancet 2011;378:41-8)
  • ATLAS ACS-2 (N Engl J Med 2012 ; 366 : 919)
Recommendations from T. Sirich
  • Hemodialysis
  1. National Cooperative Dialysis Study (NCDS), Lowrie et al, NEJM 1981.
  2. A mechanistic analysis of the National Cooperative Dialysis Study (NCDS), Gotch and Sargent, Kidney International 1985
  3. Effect of dialysis dose and membrane flux in maintenance hemodialysis (HEMO study), Eknoyan et al, NEJM 2002.
  4. In-center hemodialysis six times per week versus three times per week (FHN study), Chertow et al, NEJM 2010.
  • Continuous renal replacement therapy
  1. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury (ATN trial), NEJM 2008
  • Peritoneal dialysis
  1. Adequacy of dialysis and nutrition in continuous peritoneal dialysis: association with clinical outcomes. Canada-USA (CANUSA) Peritoneal Dialysis Study Group, JASN 1996.
  2. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial (ADEMEX), JASN 2002.
--mlam 00:08, 24 May 2012 (PDT)

Additional Resources

I found this and thought that it might be helpful [22]

Infamous Lancet autism article

Hi team! What are people's thoughts about including this trial (now retracted) from Lancet that helped build the anti-vaccination campaign? --Tim Plante 17:31, 30 October 2012 (PDT)

I'm all for it. --Dave Iberri 16:59, 5 February 2013 (PST)

More Suggested links


From the kind folks in the FOAM team (T. Raine and S. Trueger)

  • weingart levitan on oxygenation
  • lactate clearance vs scvo2 in sepsis (jones, shapiro 2010)
  • PECARN on imaging mTBI in kids (Kuppermann 2009)
  • R Body on HPI features of AMI [23]
  • overview of crowding [24]
  • seminal paper on boarding as the source of crowding [25]
  • we diagnosis lots more PEs but can't do anything about it except make people bleed [26]
  • odds ratios of individual hpi & pe elements for PE (from PERC dataset) Courtney DM, Kline JA et al [27]
  • single hypotensive episode in ED associated w/ mortality [28]
  • perry CT for SAH within 6h of onset [29]
  • just 2 of the major panscan in trauma articles [30] [31] (the second one has 2 different conclusions from surgeons vs EM)
  • lack of utility of stress tests on <40 yo [32]
  • no difference in typical vs atypical vs no chest pain anginal equivalent [33]
  • low yield of stress tests [34]
  • Failure of electric shock treatment for rattlesnake envenomation [35]
"Based on their understanding of an article in an outdoorsman's magazine, the patient and his neighbor had previously established a plan to use electric shock treatment if either was envenomated. The patient was placed supine next to a car, and a spark plug wire was attached to his upper lip by a wire with a small clip at each end. The engine was started and repeatedly rewed to 3,000 rpm for approximately five minutes. The patient lost consciousness with the first electrical charge."

--Tim Plante (talk) 06:37, 3 August 2013 (PDT)


  • Non-DHP CCBs in DM nephropathy, will need to choose best trial from this list --Tim Plante (talk) 07:12, 3 August 2013 (PDT)